

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | cytoplasmic mRNA processing body assembly (GO:0033962) | 6.54914779 |
| 2 | nuclear pore complex assembly (GO:0051292) | 5.86844513 |
| 3 | nuclear pore organization (GO:0006999) | 5.66952339 |
| 4 | regulation of establishment of cell polarity (GO:2000114) | 5.23518660 |
| 5 | protein localization to kinetochore (GO:0034501) | 4.91680256 |
| 6 | mitotic sister chromatid cohesion (GO:0007064) | 4.81850507 |
| 7 | pore complex assembly (GO:0046931) | 4.52748706 |
| 8 | DNA unwinding involved in DNA replication (GO:0006268) | 4.52638757 |
| 9 | mitotic chromosome condensation (GO:0007076) | 4.38696704 |
| 10 | protein localization to chromosome, centromeric region (GO:0071459) | 4.35537142 |
| 11 | mitotic nuclear envelope disassembly (GO:0007077) | 4.18806955 |
| 12 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 4.18034649 |
| 13 | kinetochore organization (GO:0051383) | 4.15746379 |
| 14 | regulation of establishment or maintenance of cell polarity (GO:0032878) | 4.14837927 |
| 15 | sister chromatid segregation (GO:0000819) | 4.09460803 |
| 16 | regulation of histone H3-K9 methylation (GO:0051570) | 3.98140602 |
| 17 | mitotic sister chromatid segregation (GO:0000070) | 3.93313788 |
| 18 | nuclear envelope disassembly (GO:0051081) | 3.90321396 |
| 19 | membrane disassembly (GO:0030397) | 3.90321396 |
| 20 | DNA synthesis involved in DNA repair (GO:0000731) | 3.88113147 |
| 21 | regulation of MHC class I biosynthetic process (GO:0045343) | 3.77149902 |
| 22 | stress granule assembly (GO:0034063) | 3.77051609 |
| 23 | mitotic metaphase plate congression (GO:0007080) | 3.72652863 |
| 24 | DNA geometric change (GO:0032392) | 3.71847485 |
| 25 | negative regulation of histone methylation (GO:0031061) | 3.71104839 |
| 26 | DNA duplex unwinding (GO:0032508) | 3.70566839 |
| 27 | histone H3-K4 trimethylation (GO:0080182) | 3.69280516 |
| 28 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.65770872 |
| 29 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.65770872 |
| 30 | DNA replication initiation (GO:0006270) | 3.65128318 |
| 31 | meiotic chromosome segregation (GO:0045132) | 3.64514535 |
| 32 | regulation of spindle organization (GO:0090224) | 3.61851080 |
| 33 | pre-miRNA processing (GO:0031054) | 3.61436083 |
| 34 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.58265371 |
| 35 | metaphase plate congression (GO:0051310) | 3.57345357 |
| 36 | mitotic G2/M transition checkpoint (GO:0044818) | 3.55270158 |
| 37 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 3.54881786 |
| 38 | positive regulation of mitotic metaphase/anaphase transition (GO:0045842) | 3.53662253 |
| 39 | positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101) | 3.53662253 |
| 40 | positive regulation of mitotic sister chromatid separation (GO:1901970) | 3.53662253 |
| 41 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.51595450 |
| 42 | peptidyl-lysine trimethylation (GO:0018023) | 3.51560729 |
| 43 | positive regulation of chromosome segregation (GO:0051984) | 3.49642921 |
| 44 | synapsis (GO:0007129) | 3.49377904 |
| 45 | regulation of sister chromatid cohesion (GO:0007063) | 3.48447885 |
| 46 | regulation of RNA export from nucleus (GO:0046831) | 3.47356172 |
| 47 | chromatin remodeling at centromere (GO:0031055) | 3.47310746 |
| 48 | regulation of mitotic spindle organization (GO:0060236) | 3.44769194 |
| 49 | negative regulation of G2/M transition of mitotic cell cycle (GO:0010972) | 3.42482734 |
| 50 | CENP-A containing nucleosome assembly (GO:0034080) | 3.39282571 |
| 51 | DNA strand elongation (GO:0022616) | 3.37802624 |
| 52 | DNA replication-independent nucleosome organization (GO:0034724) | 3.36789661 |
| 53 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.36789661 |
| 54 | protein localization to chromosome (GO:0034502) | 3.35424142 |
| 55 | histone-serine phosphorylation (GO:0035404) | 3.35182448 |
| 56 | kinetochore assembly (GO:0051382) | 3.34095130 |
| 57 | mitotic recombination (GO:0006312) | 3.33420474 |
| 58 | phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092) | 3.33184166 |
| 59 | microtubule depolymerization (GO:0007019) | 3.32659895 |
| 60 | non-recombinational repair (GO:0000726) | 3.30968892 |
| 61 | double-strand break repair via nonhomologous end joining (GO:0006303) | 3.30968892 |
| 62 | histone H3-K36 demethylation (GO:0070544) | 3.30687033 |
| 63 | IMP biosynthetic process (GO:0006188) | 3.29973400 |
| 64 | establishment of chromosome localization (GO:0051303) | 3.29478249 |
| 65 | negative regulation of cell cycle G2/M phase transition (GO:1902750) | 3.29342886 |
| 66 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.26798540 |
| 67 | interkinetic nuclear migration (GO:0022027) | 3.26738718 |
| 68 | DNA replication checkpoint (GO:0000076) | 3.26394646 |
| 69 | chromatin assembly or disassembly (GO:0006333) | 3.25549089 |
| 70 | response to X-ray (GO:0010165) | 3.24923241 |
| 71 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.23944634 |
| 72 | dosage compensation (GO:0007549) | 3.23554794 |
| 73 | regulation of centriole replication (GO:0046599) | 3.23412652 |
| 74 | heterochromatin organization (GO:0070828) | 3.21836786 |
| 75 | regulation of DNA endoreduplication (GO:0032875) | 3.21518417 |
| 76 | centriole replication (GO:0007099) | 3.20653565 |
| 77 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.20459340 |
| 78 | telomere maintenance via recombination (GO:0000722) | 3.18993933 |
| 79 | chromatin assembly (GO:0031497) | 3.18839724 |
| 80 | DNA conformation change (GO:0071103) | 3.18297711 |
| 81 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 3.17367696 |
| 82 | microtubule polymerization or depolymerization (GO:0031109) | 3.13652745 |
| 83 | nucleus organization (GO:0006997) | 3.13235596 |
| 84 | microtubule anchoring (GO:0034453) | 3.12957576 |
| 85 | phospholipid translocation (GO:0045332) | 3.12446038 |
| 86 | lipid translocation (GO:0034204) | 3.12446038 |
| 87 | regulation of memory T cell differentiation (GO:0043380) | 3.11776915 |
| 88 | translesion synthesis (GO:0019985) | 3.10349905 |
| 89 | regulation of chromosome segregation (GO:0051983) | 3.09763347 |
| 90 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.09411064 |
| 91 | sex differentiation (GO:0007548) | 3.08485316 |
| 92 | histone exchange (GO:0043486) | 3.04835760 |
| 93 | chromosome condensation (GO:0030261) | 3.04480482 |
| 94 | chromosome segregation (GO:0007059) | 3.04056228 |
| 95 | regulation of centrosome cycle (GO:0046605) | 3.03219150 |
| 96 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.01985504 |
| 97 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.01985504 |
| 98 | nuclear envelope organization (GO:0006998) | 3.01786746 |
| 99 | alternative mRNA splicing, via spliceosome (GO:0000380) | 3.01529061 |
| 100 | DNA topological change (GO:0006265) | 3.01167853 |
| 101 | spindle checkpoint (GO:0031577) | 2.98142793 |
| 102 | histone phosphorylation (GO:0016572) | 2.96665593 |
| 103 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 2.96225556 |
| 104 | monoubiquitinated protein deubiquitination (GO:0035520) | 2.96032362 |
| 105 | V(D)J recombination (GO:0033151) | 2.95126299 |
| 106 | protein K6-linked ubiquitination (GO:0085020) | 2.94854806 |
| 107 | sister chromatid cohesion (GO:0007062) | 2.91870569 |
| 108 | IMP metabolic process (GO:0046040) | 2.90044058 |
| 109 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 2.89123584 |
| 110 | regulation of helicase activity (GO:0051095) | 2.88917320 |
| 111 | protein K11-linked deubiquitination (GO:0035871) | 2.88635952 |
| 112 | DNA packaging (GO:0006323) | 2.88147997 |
| 113 | ATP-dependent chromatin remodeling (GO:0043044) | 2.88001096 |
| 114 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 2.87754088 |
| 115 | negative regulation of type 2 immune response (GO:0002829) | 2.87674813 |
| 116 | spindle assembly checkpoint (GO:0071173) | 2.87133298 |
| 117 | negative regulation of chromosome segregation (GO:0051985) | 2.82295015 |
| 118 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 2.81736215 |
| 119 | negative regulation of DNA repair (GO:0045738) | 2.80314753 |
| 120 | regulation of sister chromatid segregation (GO:0033045) | 2.80024560 |
| 121 | regulation of mitotic sister chromatid separation (GO:0010965) | 2.80024560 |
| 122 | regulation of mitotic sister chromatid segregation (GO:0033047) | 2.80024560 |
| 123 | telomere maintenance (GO:0000723) | 2.79571515 |
| 124 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 2.79472388 |
| 125 | mismatch repair (GO:0006298) | 2.78233926 |
| 126 | telomere maintenance via telomere lengthening (GO:0010833) | 2.77309028 |
| 127 | telomere organization (GO:0032200) | 2.76602406 |
| 128 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 2.76024396 |
| 129 | negative regulation of sister chromatid segregation (GO:0033046) | 2.76024396 |
| 130 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 2.76024396 |
| 131 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 2.76024396 |
| 132 | nucleobase biosynthetic process (GO:0046112) | 2.74873677 |
| 133 | mitotic spindle checkpoint (GO:0071174) | 2.74706695 |
| 134 | mitotic spindle assembly checkpoint (GO:0007094) | 2.73375935 |
| 135 | regulation of centrosome duplication (GO:0010824) | 2.73093609 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | * FOXM1_23109430_ChIP-Seq_U2OS_Human | 5.80647706 |
| 2 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 4.46033098 |
| 3 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 3.63866164 |
| 4 | * FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 3.43805346 |
| 5 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.96127019 |
| 6 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 2.63556569 |
| 7 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 2.46307042 |
| 8 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 2.38850384 |
| 9 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.28592024 |
| 10 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 2.22799222 |
| 11 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.22358477 |
| 12 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.19174061 |
| 13 | MYC_22102868_ChIP-Seq_BL_Human | 2.15418831 |
| 14 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.15344004 |
| 15 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.09556211 |
| 16 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.04784110 |
| 17 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 2.01613756 |
| 18 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.00703833 |
| 19 | E2F7_22180533_ChIP-Seq_HELA_Human | 11.1088728 |
| 20 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.90718618 |
| 21 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.89965646 |
| 22 | GATA1_22025678_ChIP-Seq_K562_Human | 1.84685695 |
| 23 | FUS_26573619_Chip-Seq_HEK293_Human | 1.84589745 |
| 24 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.80481577 |
| 25 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.78030345 |
| 26 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.75132719 |
| 27 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.74097418 |
| 28 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.66716304 |
| 29 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.66383641 |
| 30 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.65857374 |
| 31 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.63508749 |
| 32 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.60779504 |
| 33 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.60454822 |
| 34 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.57850590 |
| 35 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.56672313 |
| 36 | * VDR_23849224_ChIP-Seq_CD4+_Human | 1.51847792 |
| 37 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.50749165 |
| 38 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.50489184 |
| 39 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.50212386 |
| 40 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.48839097 |
| 41 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 1.47138152 |
| 42 | STAT3_23295773_ChIP-Seq_U87_Human | 1.46339410 |
| 43 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.46326110 |
| 44 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.44180824 |
| 45 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.43806715 |
| 46 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.43560931 |
| 47 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.42626587 |
| 48 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.38743165 |
| 49 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.36919245 |
| 50 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.36913669 |
| 51 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.34805951 |
| 52 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.33961456 |
| 53 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.33806293 |
| 54 | FOXM1_26456572_ChIP-Seq_MCF-7_Human | 1.33382218 |
| 55 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.33266457 |
| 56 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.32572406 |
| 57 | FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human | 1.32321967 |
| 58 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.31714665 |
| 59 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.29606472 |
| 60 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.29558558 |
| 61 | EWS_26573619_Chip-Seq_HEK293_Human | 1.28947348 |
| 62 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.24701502 |
| 63 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.23561264 |
| 64 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 1.22412506 |
| 65 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.22091645 |
| 66 | VDR_22108803_ChIP-Seq_LS180_Human | 1.21555478 |
| 67 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.21333892 |
| 68 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.19554037 |
| 69 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.19480464 |
| 70 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.18952878 |
| 71 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.18095446 |
| 72 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.17838737 |
| 73 | TCF4_23295773_ChIP-Seq_U87_Human | 1.16699709 |
| 74 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.15853650 |
| 75 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.15790436 |
| 76 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 1.15575770 |
| 77 | MYB_26560356_Chip-Seq_TH1_Human | 1.15019469 |
| 78 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.14688648 |
| 79 | * MYB_26560356_Chip-Seq_TH2_Human | 1.13937026 |
| 80 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.13779769 |
| 81 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.12963025 |
| 82 | TP53_16413492_ChIP-PET_HCT116_Human | 1.12512300 |
| 83 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.12410273 |
| 84 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 1.12055579 |
| 85 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.11766603 |
| 86 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.09465900 |
| 87 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.09144907 |
| 88 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.08829944 |
| 89 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.08362381 |
| 90 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.07370991 |
| 91 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.06859269 |
| 92 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.06715558 |
| 93 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.06325901 |
| 94 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 1.06032643 |
| 95 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.06022237 |
| 96 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.05907682 |
| 97 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.05683563 |
| 98 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.03646569 |
| 99 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.02894827 |
| 100 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.02514694 |
| 101 | BRD4_25478319_ChIP-Seq_HGPS_Human | 1.02409527 |
| 102 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.01797852 |
| 103 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.01627350 |
| 104 | * UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.01172806 |
| 105 | * ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.00925969 |
| 106 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 1.00372954 |
| 107 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.99509746 |
| 108 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 0.99373772 |
| 109 | TCF7_22412390_ChIP-Seq_EML_Mouse | 0.99302781 |
| 110 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.99298738 |
| 111 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 0.98487064 |
| 112 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.98206604 |
| 113 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 0.98117618 |
| 114 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.97172191 |
| 115 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 0.96522322 |
| 116 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 0.95588307 |
| 117 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 0.95588307 |
| 118 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 0.95588307 |
| 119 | UTX_26944678_Chip-Seq_JUKART_Human | 0.95533320 |
| 120 | AR_21572438_ChIP-Seq_LNCaP_Human | 0.95512071 |
| 121 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.95448150 |
| 122 | MAF_26560356_Chip-Seq_TH1_Human | 0.94575643 |
| 123 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 0.94151870 |
| 124 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 0.94098011 |
| 125 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 0.93906955 |
| 126 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.92402505 |
| 127 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 0.92359241 |
| 128 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.92335935 |
| 129 | SCL_19346495_ChIP-Seq_HPC-7_Human | 0.91276219 |
| 130 | CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse | 0.90990492 |
| 131 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 0.90915115 |
| 132 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 0.90766876 |
| 133 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.90598202 |
| 134 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 0.90361732 |
| 135 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 0.90313877 |
| 136 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.90014258 |
| 137 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.89685931 |
| 138 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.88905485 |
| 139 | SOX9_26525672_Chip-Seq_HEART_Mouse | 0.88493359 |
| 140 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.88341435 |
| 141 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 0.87990968 |
| 142 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 0.87942938 |
| 143 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.87805268 |
| 144 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 0.87338664 |
| 145 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.87311109 |
| 146 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 0.86692050 |
| 147 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 0.86666716 |
| 148 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 0.86662381 |
| 149 | PKCTHETA_26484144_Chip-Seq_BREAST_Human | 0.85880888 |
| 150 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.85291825 |
| 151 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.85291825 |
| 152 | FOXA1_26743006_Chip-Seq_LNCaP-abl_Human | 0.84859995 |
| 153 | P300_19829295_ChIP-Seq_ESCs_Human | 0.84835713 |
| 154 | TBL1_22424771_ChIP-Seq_293T_Human | 0.83951177 |
| 155 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.83109839 |
| 156 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 0.83091254 |
| 157 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 0.81917138 |
| 158 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.81815843 |
| 159 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.81128491 |
| 160 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 0.79241997 |
| 161 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.77386763 |
| 162 | CDX2_22108803_ChIP-Seq_LS180_Human | 0.76516217 |
| 163 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.76476976 |
| 164 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.75909665 |
| 165 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.75909665 |
| 166 | GF1B_26923725_Chip-Seq_HPCs_Mouse | 0.75738640 |
| 167 | * KDM2B_26808549_Chip-Seq_REH_Human | 0.75595229 |
| 168 | TCF4_18268006_ChIP-ChIP_LS174T_Human | 0.75544987 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0010094_abnormal_chromosome_stability | 4.20632185 |
| 2 | MP0008057_abnormal_DNA_replication | 3.94384567 |
| 3 | MP0003693_abnormal_embryo_hatching | 3.75730466 |
| 4 | MP0003111_abnormal_nucleus_morphology | 3.72615012 |
| 5 | MP0003077_abnormal_cell_cycle | 3.39328871 |
| 6 | MP0004957_abnormal_blastocyst_morpholog | 3.05339201 |
| 7 | MP0002396_abnormal_hematopoietic_system | 2.75316283 |
| 8 | MP0010307_abnormal_tumor_latency | 2.69135390 |
| 9 | MP0010352_gastrointestinal_tract_polyps | 2.65403687 |
| 10 | MP0008058_abnormal_DNA_repair | 2.61243675 |
| 11 | MP0009697_abnormal_copulation | 2.46379632 |
| 12 | MP0008007_abnormal_cellular_replicative | 2.39367617 |
| 13 | MP0008877_abnormal_DNA_methylation | 2.27954198 |
| 14 | MP0005076_abnormal_cell_differentiation | 2.23104935 |
| 15 | MP0003252_abnormal_bile_duct | 2.11297550 |
| 16 | MP0003123_paternal_imprinting | 2.09589455 |
| 17 | MP0000350_abnormal_cell_proliferation | 2.09332443 |
| 18 | MP0000569_abnormal_digit_pigmentation | 2.04977368 |
| 19 | MP0004808_abnormal_hematopoietic_stem | 2.01494614 |
| 20 | MP0001730_embryonic_growth_arrest | 2.01255982 |
| 21 | MP0003950_abnormal_plasma_membrane | 1.99861106 |
| 22 | MP0003121_genomic_imprinting | 1.89263847 |
| 23 | MP0008932_abnormal_embryonic_tissue | 1.78983100 |
| 24 | MP0005380_embryogenesis_phenotype | 1.72794238 |
| 25 | MP0001672_abnormal_embryogenesis/_devel | 1.72794238 |
| 26 | MP0003984_embryonic_growth_retardation | 1.62640355 |
| 27 | MP0002088_abnormal_embryonic_growth/wei | 1.60030729 |
| 28 | MP0001697_abnormal_embryo_size | 1.58725062 |
| 29 | MP0004197_abnormal_fetal_growth/weight/ | 1.57278522 |
| 30 | MP0002086_abnormal_extraembryonic_tissu | 1.56751935 |
| 31 | MP0002084_abnormal_developmental_patter | 1.53701747 |
| 32 | MP0000383_abnormal_hair_follicle | 1.50473061 |
| 33 | MP0000490_abnormal_crypts_of | 1.49599606 |
| 34 | MP0003718_maternal_effect | 1.48739169 |
| 35 | MP0009278_abnormal_bone_marrow | 1.46851789 |
| 36 | MP0003763_abnormal_thymus_physiology | 1.45806507 |
| 37 | MP0002085_abnormal_embryonic_tissue | 1.45046201 |
| 38 | MP0000703_abnormal_thymus_morphology | 1.41271670 |
| 39 | MP0002398_abnormal_bone_marrow | 1.41046442 |
| 40 | MP0003705_abnormal_hypodermis_morpholog | 1.40812551 |
| 41 | MP0005397_hematopoietic_system_phenotyp | 1.38531474 |
| 42 | MP0001545_abnormal_hematopoietic_system | 1.38531474 |
| 43 | MP0010678_abnormal_skin_adnexa | 1.38058760 |
| 44 | MP0008961_abnormal_basal_metabolism | 1.37309252 |
| 45 | MP0002080_prenatal_lethality | 1.37191756 |
| 46 | MP0003786_premature_aging | 1.35897461 |
| 47 | MP0002019_abnormal_tumor_incidence | 1.32244948 |
| 48 | MP0001661_extended_life_span | 1.30029700 |
| 49 | MP0003567_abnormal_fetal_cardiomyocyte | 1.29634263 |
| 50 | MP0000313_abnormal_cell_death | 1.26323064 |
| 51 | MP0003890_abnormal_embryonic-extraembry | 1.24483680 |
| 52 | MP0002166_altered_tumor_susceptibility | 1.23260069 |
| 53 | MP0001835_abnormal_antigen_presentation | 1.22157527 |
| 54 | MP0000427_abnormal_hair_cycle | 1.21047538 |
| 55 | MP0004381_abnormal_hair_follicle | 1.19127814 |
| 56 | MP0001800_abnormal_humoral_immune | 1.18953452 |
| 57 | MP0002722_abnormal_immune_system | 1.18332396 |
| 58 | MP0003566_abnormal_cell_adhesion | 1.18150845 |
| 59 | MP0001293_anophthalmia | 1.18036884 |
| 60 | MP0002006_tumorigenesis | 1.17811725 |
| 61 | MP0003656_abnormal_erythrocyte_physiolo | 1.14359772 |
| 62 | MP0000689_abnormal_spleen_morphology | 1.13692780 |
| 63 | MP0003787_abnormal_imprinting | 1.09123940 |
| 64 | MP0002877_abnormal_melanocyte_morpholog | 1.08363466 |
| 65 | MP0002210_abnormal_sex_determination | 1.06042200 |
| 66 | MP0000015_abnormal_ear_pigmentation | 1.05184743 |
| 67 | MP0001915_intracranial_hemorrhage | 1.01976374 |
| 68 | MP0001986_abnormal_taste_sensitivity | 1.00579366 |
| 69 | MP0005409_darkened_coat_color | 1.00563862 |
| 70 | MP0009703_decreased_birth_body | 1.00315111 |
| 71 | MP0005310_abnormal_salivary_gland | 0.99877895 |
| 72 | MP0005408_hypopigmentation | 0.99366199 |
| 73 | MP0000716_abnormal_immune_system | 0.98408631 |
| 74 | MP0003300_gastrointestinal_ulcer | 0.98194040 |
| 75 | MP0002452_abnormal_antigen_presenting | 0.98178880 |
| 76 | MP0002429_abnormal_blood_cell | 0.97580309 |
| 77 | MP0000733_abnormal_muscle_development | 0.97467292 |
| 78 | MP0002009_preneoplasia | 0.97362868 |
| 79 | MP0005023_abnormal_wound_healing | 0.96748463 |
| 80 | MP0000685_abnormal_immune_system | 0.95166957 |
| 81 | MP0003698_abnormal_male_reproductive | 0.94286598 |
| 82 | MP0004264_abnormal_extraembryonic_tissu | 0.92837650 |
| 83 | MP0003868_abnormal_feces_composition | 0.91952148 |
| 84 | MP0002420_abnormal_adaptive_immunity | 0.91321956 |
| 85 | MP0001145_abnormal_male_reproductive | 0.91216917 |
| 86 | MP0009333_abnormal_splenocyte_physiolog | 0.91170518 |
| 87 | MP0004233_abnormal_muscle_weight | 0.90417934 |
| 88 | MP0001819_abnormal_immune_cell | 0.90113724 |
| 89 | MP0010234_abnormal_vibrissa_follicle | 0.89875047 |
| 90 | MP0003699_abnormal_female_reproductive | 0.89795540 |
| 91 | MP0005671_abnormal_response_to | 0.88751254 |
| 92 | MP0003646_muscle_fatigue | 0.88401238 |
| 93 | MP0005621_abnormal_cell_physiology | 0.88195604 |
| 94 | MP0009672_abnormal_birth_weight | 0.88159152 |
| 95 | MP0001929_abnormal_gametogenesis | 0.87418981 |
| 96 | MP0009053_abnormal_anal_canal | 0.84768584 |
| 97 | MP0005395_other_phenotype | 0.84107945 |
| 98 | MP0000537_abnormal_urethra_morphology | 0.83804039 |
| 99 | MP0003448_altered_tumor_morphology | 0.83451167 |
| 100 | MP0002925_abnormal_cardiovascular_devel | 0.83293657 |
| 101 | MP0009115_abnormal_fat_cell | 0.82815084 |
| 102 | MP0000858_altered_metastatic_potential | 0.82678852 |
| 103 | MP0002723_abnormal_immune_serum | 0.82293142 |
| 104 | MP0005647_abnormal_sex_gland | 0.82053049 |
| 105 | MP0002405_respiratory_system_inflammati | 0.81156889 |
| 106 | MP0003221_abnormal_cardiomyocyte_apopto | 0.80674767 |
| 107 | MP0005384_cellular_phenotype | 0.80301377 |
| 108 | MP0003937_abnormal_limbs/digits/tail_de | 0.79455027 |
| 109 | MP0005174_abnormal_tail_pigmentation | 0.78576201 |
| 110 | MP0006054_spinal_hemorrhage | 0.78205590 |
| 111 | MP0002092_abnormal_eye_morphology | 0.77213251 |
| 112 | MP0000371_diluted_coat_color | 0.76109281 |
| 113 | MP0000653_abnormal_sex_gland | 0.75993181 |
| 114 | MP0000432_abnormal_head_morphology | 0.73698294 |
| 115 | MP0001873_stomach_inflammation | 0.73053393 |
| 116 | MP0005075_abnormal_melanosome_morpholog | 0.72619045 |
| 117 | MP0010030_abnormal_orbit_morphology | 0.71899596 |
| 118 | MP0000428_abnormal_craniofacial_morphol | 0.71121452 |
| 119 | MP0008770_decreased_survivor_rate | 0.70334881 |
| 120 | MP0010155_abnormal_intestine_physiology | 0.69517185 |
| 121 | MP0003935_abnormal_craniofacial_develop | 0.68218852 |
| 122 | MP0002161_abnormal_fertility/fecundity | 0.67958002 |
| 123 | MP0001119_abnormal_female_reproductive | 0.67591266 |
| 124 | MP0002075_abnormal_coat/hair_pigmentati | 0.66938779 |
| 125 | MP0001666_abnormal_nutrient_absorption | 0.66272960 |
| 126 | MP0006035_abnormal_mitochondrial_morpho | 0.65380896 |
| 127 | MP0003115_abnormal_respiratory_system | 0.65292815 |
| 128 | MP0002697_abnormal_eye_size | 0.64984130 |
| 129 | MP0003943_abnormal_hepatobiliary_system | 0.64098588 |
| 130 | MP0001790_abnormal_immune_system | 0.63345330 |
| 131 | MP0005387_immune_system_phenotype | 0.63345330 |
| 132 | MP0005410_abnormal_fertilization | 0.63263699 |
| 133 | MP0002095_abnormal_skin_pigmentation | 0.63238754 |
| 134 | MP0000266_abnormal_heart_morphology | 0.62851843 |
| 135 | MP0004130_abnormal_muscle_cell | 0.61622021 |
| 136 | MP0001286_abnormal_eye_development | 0.59154794 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Dysmetric saccades (HP:0000641) | 5.83400807 |
| 2 | Genetic anticipation (HP:0003743) | 4.67620965 |
| 3 | Chromsome breakage (HP:0040012) | 4.12745508 |
| 4 | Volvulus (HP:0002580) | 3.73544993 |
| 5 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.72236000 |
| 6 | Abnormality of chromosome stability (HP:0003220) | 3.30667742 |
| 7 | Ependymoma (HP:0002888) | 3.27650227 |
| 8 | Prostate neoplasm (HP:0100787) | 3.21452825 |
| 9 | Abnormality of the fingertips (HP:0001211) | 3.18650121 |
| 10 | Medulloblastoma (HP:0002885) | 3.11465440 |
| 11 | Action tremor (HP:0002345) | 3.00416176 |
| 12 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 2.99294819 |
| 13 | Short 4th metacarpal (HP:0010044) | 2.99294819 |
| 14 | Gaze-evoked nystagmus (HP:0000640) | 2.99262512 |
| 15 | Ectopic kidney (HP:0000086) | 2.96268147 |
| 16 | Slow saccadic eye movements (HP:0000514) | 2.92483653 |
| 17 | Selective tooth agenesis (HP:0001592) | 2.86590741 |
| 18 | Birth length less than 3rd percentile (HP:0003561) | 2.85911171 |
| 19 | Papillary thyroid carcinoma (HP:0002895) | 2.83256416 |
| 20 | Increased nuchal translucency (HP:0010880) | 2.75424512 |
| 21 | Agnosia (HP:0010524) | 2.75381428 |
| 22 | Abnormality of the hepatic vasculature (HP:0006707) | 2.70195094 |
| 23 | Colon cancer (HP:0003003) | 2.70078755 |
| 24 | Deviation of the thumb (HP:0009603) | 2.65406300 |
| 25 | Progressive cerebellar ataxia (HP:0002073) | 2.64014267 |
| 26 | Prominent nose (HP:0000448) | 2.63481666 |
| 27 | Rhabdomyosarcoma (HP:0002859) | 2.59877876 |
| 28 | Proximal placement of thumb (HP:0009623) | 2.59452545 |
| 29 | Impulsivity (HP:0100710) | 2.57338919 |
| 30 | Myelodysplasia (HP:0002863) | 2.56965267 |
| 31 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.56191183 |
| 32 | Meckel diverticulum (HP:0002245) | 2.55376570 |
| 33 | Abnormality of the astrocytes (HP:0100707) | 2.54429295 |
| 34 | Astrocytoma (HP:0009592) | 2.54429295 |
| 35 | Neoplasm of the oral cavity (HP:0100649) | 2.43860498 |
| 36 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.42993923 |
| 37 | Abnormality of the ileum (HP:0001549) | 2.41713932 |
| 38 | Acute myeloid leukemia (HP:0004808) | 2.41684645 |
| 39 | Long eyelashes (HP:0000527) | 2.41600823 |
| 40 | Reticulocytopenia (HP:0001896) | 2.40083415 |
| 41 | Abnormality of the preputium (HP:0100587) | 2.36997761 |
| 42 | Abnormality of the labia minora (HP:0012880) | 2.34735040 |
| 43 | Glioma (HP:0009733) | 2.30046291 |
| 44 | High pitched voice (HP:0001620) | 2.24936919 |
| 45 | Dysdiadochokinesis (HP:0002075) | 2.24401746 |
| 46 | Impaired vibratory sensation (HP:0002495) | 2.24337598 |
| 47 | Small intestinal stenosis (HP:0012848) | 2.23119729 |
| 48 | Duodenal stenosis (HP:0100867) | 2.23119729 |
| 49 | Subacute progressive viral hepatitis (HP:0006572) | 2.21042941 |
| 50 | Basal cell carcinoma (HP:0002671) | 2.20771848 |
| 51 | Abnormal number of incisors (HP:0011064) | 2.19636606 |
| 52 | Cafe-au-lait spot (HP:0000957) | 2.17668024 |
| 53 | Amaurosis fugax (HP:0100576) | 2.15818294 |
| 54 | Neoplasm of striated muscle (HP:0009728) | 2.15545495 |
| 55 | Abnormality of the carotid arteries (HP:0005344) | 2.13729118 |
| 56 | Biliary tract neoplasm (HP:0100574) | 2.13634045 |
| 57 | Tubulointerstitial nephritis (HP:0001970) | 2.13531464 |
| 58 | Deep philtrum (HP:0002002) | 2.12693783 |
| 59 | Patellar aplasia (HP:0006443) | 2.12355785 |
| 60 | Fair hair (HP:0002286) | 2.11068227 |
| 61 | Acanthocytosis (HP:0001927) | 2.10556219 |
| 62 | Hypopigmentation of the fundus (HP:0007894) | 2.10121561 |
| 63 | Abnormal biliary tract morphology (HP:0012440) | 2.06718221 |
| 64 | 11 pairs of ribs (HP:0000878) | 2.05573889 |
| 65 | Sloping forehead (HP:0000340) | 2.04990256 |
| 66 | Sandal gap (HP:0001852) | 2.03838058 |
| 67 | Nephroblastoma (Wilms tumor) (HP:0002667) | 2.02136080 |
| 68 | Postural instability (HP:0002172) | 2.01488984 |
| 69 | Obsessive-compulsive behavior (HP:0000722) | 2.01465081 |
| 70 | Relative macrocephaly (HP:0004482) | 2.00388634 |
| 71 | Heterotopia (HP:0002282) | 1.99027403 |
| 72 | Large earlobe (HP:0009748) | 1.98584355 |
| 73 | Submucous cleft hard palate (HP:0000176) | 1.98142817 |
| 74 | Malignant gastrointestinal tract tumors (HP:0006749) | 1.97905629 |
| 75 | Gastrointestinal carcinoma (HP:0002672) | 1.97905629 |
| 76 | Truncal obesity (HP:0001956) | 1.97601164 |
| 77 | Facial hemangioma (HP:0000329) | 1.95310098 |
| 78 | Abnormality of the 4th metacarpal (HP:0010012) | 1.94772638 |
| 79 | IgM deficiency (HP:0002850) | 1.93734676 |
| 80 | Recurrent viral infections (HP:0004429) | 1.92377246 |
| 81 | Aplasia/Hypoplasia of the patella (HP:0006498) | 1.91448789 |
| 82 | Absent thumb (HP:0009777) | 1.90875227 |
| 83 | Supernumerary spleens (HP:0009799) | 1.90291498 |
| 84 | Embryonal renal neoplasm (HP:0011794) | 1.89770395 |
| 85 | Skull defect (HP:0001362) | 1.89689784 |
| 86 | Clubbing of toes (HP:0100760) | 1.88785517 |
| 87 | Arteriovenous malformation (HP:0100026) | 1.88670053 |
| 88 | Absent frontal sinuses (HP:0002688) | 1.87938239 |
| 89 | Hypochromic microcytic anemia (HP:0004840) | 1.87304953 |
| 90 | Cortical dysplasia (HP:0002539) | 1.87161532 |
| 91 | Cutis marmorata (HP:0000965) | 1.86852552 |
| 92 | Missing ribs (HP:0000921) | 1.86409227 |
| 93 | Acute lymphatic leukemia (HP:0006721) | 1.86295557 |
| 94 | Ankyloglossia (HP:0010296) | 1.86002814 |
| 95 | Long clavicles (HP:0000890) | 1.85370430 |
| 96 | Abnormality of the anterior horn cell (HP:0006802) | 1.85009003 |
| 97 | Degeneration of anterior horn cells (HP:0002398) | 1.85009003 |
| 98 | Hypoplastic labia majora (HP:0000059) | 1.84762432 |
| 99 | Cystic hygroma (HP:0000476) | 1.84377800 |
| 100 | Abnormal auditory evoked potentials (HP:0006958) | 1.84187648 |
| 101 | Hypoplastic iliac wings (HP:0002866) | 1.83556601 |
| 102 | Lymphoma (HP:0002665) | 1.83553958 |
| 103 | Abnormality of the duodenum (HP:0002246) | 1.82948158 |
| 104 | Embryonal neoplasm (HP:0002898) | 1.81991860 |
| 105 | Chronic hepatic failure (HP:0100626) | 1.81355961 |
| 106 | Urethral obstruction (HP:0000796) | 1.81036168 |
| 107 | Bone marrow hypocellularity (HP:0005528) | 1.80724944 |
| 108 | Supernumerary ribs (HP:0005815) | 1.79966803 |
| 109 | Duplicated collecting system (HP:0000081) | 1.78867457 |
| 110 | Aplasia/Hypoplasia of the earlobes (HP:0009906) | 1.78556525 |
| 111 | Overlapping toe (HP:0001845) | 1.78346687 |
| 112 | Low anterior hairline (HP:0000294) | 1.77672482 |
| 113 | Atresia of the external auditory canal (HP:0000413) | 1.76671190 |
| 114 | Abnormality of the labia majora (HP:0012881) | 1.76060621 |
| 115 | Impaired smooth pursuit (HP:0007772) | 1.75349311 |
| 116 | Abnormality of DNA repair (HP:0003254) | 1.75045452 |
| 117 | Absent radius (HP:0003974) | 1.74329233 |
| 118 | Abnormality of pyrimidine metabolism (HP:0004353) | 1.74176731 |
| 119 | Broad palm (HP:0001169) | 1.74009615 |
| 120 | Trigonocephaly (HP:0000243) | 1.73826561 |
| 121 | Abnormal lung lobation (HP:0002101) | 1.73544452 |
| 122 | Viral hepatitis (HP:0006562) | 1.73254370 |
| 123 | Spinal cord lesions (HP:0100561) | 1.72816045 |
| 124 | Syringomyelia (HP:0003396) | 1.72816045 |
| 125 | Colitis (HP:0002583) | 1.72375369 |
| 126 | Overgrowth (HP:0001548) | 1.72294979 |
| 127 | Subaortic stenosis (HP:0001682) | 1.72133448 |
| 128 | Abnormality of the left ventricular outflow tract (HP:0011103) | 1.72133448 |
| 129 | T lymphocytopenia (HP:0005403) | 1.71728074 |
| 130 | Supernumerary bones of the axial skeleton (HP:0009144) | 1.71302871 |
| 131 | Neoplasm of the pancreas (HP:0002894) | 1.70905680 |
| 132 | Narrow palate (HP:0000189) | 1.70002073 |
| 133 | Short thumb (HP:0009778) | 1.69644580 |
| 134 | Thyroid carcinoma (HP:0002890) | 1.69337619 |
| 135 | Cutaneous melanoma (HP:0012056) | 1.69308263 |
| 136 | Bladder carcinoma (HP:0002862) | 1.68673298 |
| 137 | Bladder neoplasm (HP:0009725) | 1.68673298 |
| 138 | Transitional cell carcinoma of the bladder (HP:0006740) | 1.68446388 |
| 139 | Hereditary nonpolyposis colorectal carcinoma (HP:0006716) | 1.68039481 |
| 140 | Broad thumb (HP:0011304) | 1.67816444 |
| 141 | Abnormality of chromosome segregation (HP:0002916) | 1.67152720 |
| 142 | IgA deficiency (HP:0002720) | 1.66828709 |
| 143 | Abnormality of the renal collecting system (HP:0004742) | 1.66724452 |
| 144 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 1.64572189 |
| 145 | Thrombocytosis (HP:0001894) | 1.64332660 |
| 146 | Tracheoesophageal fistula (HP:0002575) | 1.64283902 |
| 147 | Uterine leiomyosarcoma (HP:0002891) | 1.63657477 |
| 148 | Leiomyosarcoma (HP:0100243) | 1.63657477 |
| 149 | Anal stenosis (HP:0002025) | 1.63454910 |
| 150 | Leukopenia (HP:0001882) | 1.60869605 |
| 151 | Abnormality of T cell number (HP:0011839) | 1.60422378 |
| 152 | Blepharitis (HP:0000498) | 1.59499668 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | CDC7 | 4.63844850 |
| 2 | CDK12 | 4.09703610 |
| 3 | FRK | 3.44572122 |
| 4 | NEK2 | 3.20746242 |
| 5 | WEE1 | 2.91266578 |
| 6 | CDK19 | 2.49305505 |
| 7 | TTK | 2.37274793 |
| 8 | EEF2K | 2.33861725 |
| 9 | BRD4 | 2.13978737 |
| 10 | SRPK1 | 2.02578570 |
| 11 | STK10 | 2.00810369 |
| 12 | ATR | 1.99251694 |
| 13 | BUB1 | 1.92308816 |
| 14 | BRSK2 | 1.89921560 |
| 15 | STK3 | 1.83085478 |
| 16 | CDK4 | 1.82748103 |
| 17 | ACVR1B | 1.77618942 |
| 18 | PASK | 1.76724923 |
| 19 | MAP3K10 | 1.71164840 |
| 20 | RPS6KB2 | 1.70857146 |
| 21 | PLK1 | 1.68022151 |
| 22 | PKN2 | 1.65278526 |
| 23 | OXSR1 | 1.64586195 |
| 24 | MAP3K7 | 1.62945116 |
| 25 | AURKB | 1.62792791 |
| 26 | PLK4 | 1.61874039 |
| 27 | PBK | 1.60921642 |
| 28 | STK4 | 1.58085078 |
| 29 | AKT3 | 1.54882355 |
| 30 | CDK6 | 1.54787282 |
| 31 | MAP4K1 | 1.54102181 |
| 32 | CHEK2 | 1.49574914 |
| 33 | CHEK1 | 1.48328802 |
| 34 | CDK7 | 1.45021700 |
| 35 | MKNK1 | 1.44709854 |
| 36 | PLK3 | 1.41597323 |
| 37 | FLT3 | 1.39760119 |
| 38 | NEK1 | 1.37021492 |
| 39 | TSSK6 | 1.32242951 |
| 40 | RPS6KA4 | 1.30934468 |
| 41 | ATM | 1.29364590 |
| 42 | LATS1 | 1.28484703 |
| 43 | MAP3K8 | 1.27296865 |
| 44 | BMPR1B | 1.21503358 |
| 45 | NLK | 1.20981558 |
| 46 | TGFBR1 | 1.20414523 |
| 47 | SCYL2 | 1.19704068 |
| 48 | TLK1 | 1.18374388 |
| 49 | PIM1 | 1.16959222 |
| 50 | ZAK | 1.14813233 |
| 51 | MAP3K2 | 1.13469701 |
| 52 | MKNK2 | 1.07053573 |
| 53 | EIF2AK1 | 1.06392498 |
| 54 | WNK1 | 1.04995250 |
| 55 | CAMK1D | 1.04812768 |
| 56 | MELK | 1.02854923 |
| 57 | PIK3CG | 1.02832636 |
| 58 | DYRK3 | 1.00864225 |
| 59 | YES1 | 1.00379072 |
| 60 | CDK2 | 0.99287369 |
| 61 | JAK3 | 0.98012100 |
| 62 | MTOR | 0.96603965 |
| 63 | ALK | 0.96035360 |
| 64 | STK38L | 0.95266235 |
| 65 | MST1R | 0.93928946 |
| 66 | CDK9 | 0.91845894 |
| 67 | TAF1 | 0.90025844 |
| 68 | VRK1 | 0.88295002 |
| 69 | CLK1 | 0.82495691 |
| 70 | TTN | 0.81768816 |
| 71 | PAK4 | 0.81472237 |
| 72 | SGK2 | 0.81277794 |
| 73 | BRSK1 | 0.77375831 |
| 74 | CDK1 | 0.77154880 |
| 75 | EPHA2 | 0.76185356 |
| 76 | TYK2 | 0.75819760 |
| 77 | FGFR2 | 0.70564182 |
| 78 | BLK | 0.70356830 |
| 79 | NEK6 | 0.70199042 |
| 80 | CHUK | 0.69382896 |
| 81 | SGK3 | 0.68931475 |
| 82 | CSF1R | 0.68459824 |
| 83 | LRRK2 | 0.68358146 |
| 84 | MAP3K4 | 0.68341008 |
| 85 | KSR2 | 0.67720346 |
| 86 | KIT | 0.65156387 |
| 87 | BTK | 0.64790873 |
| 88 | MET | 0.64436369 |
| 89 | MARK3 | 0.63741727 |
| 90 | NEK9 | 0.62720478 |
| 91 | PRKAA2 | 0.62531514 |
| 92 | MAP3K13 | 0.60669654 |
| 93 | TXK | 0.60477144 |
| 94 | FGFR3 | 0.59881366 |
| 95 | MAP2K3 | 0.59523823 |
| 96 | EIF2AK3 | 0.58647922 |
| 97 | STK39 | 0.58434746 |
| 98 | NUAK1 | 0.58231022 |
| 99 | PTK6 | 0.57748471 |
| 100 | TEC | 0.56755808 |
| 101 | MAPK11 | 0.56024096 |
| 102 | ICK | 0.55355406 |
| 103 | ITK | 0.54291411 |
| 104 | CSNK1D | 0.51873745 |
| 105 | STK24 | 0.51695904 |
| 106 | KSR1 | 0.50729623 |
| 107 | CAMK1G | 0.50627504 |
| 108 | SMG1 | 0.50478022 |
| 109 | PRKDC | 0.50151044 |
| 110 | RET | 0.50060046 |
| 111 | RPS6KA5 | 0.49755530 |
| 112 | FGFR1 | 0.49600634 |
| 113 | STK11 | 0.49441603 |
| 114 | MAPK14 | 0.49031976 |
| 115 | PDGFRA | 0.48072787 |
| 116 | AURKA | 0.47741373 |
| 117 | RIPK1 | 0.47242864 |
| 118 | ZAP70 | 0.47157680 |
| 119 | SGK1 | 0.44512909 |
| 120 | PAK2 | 0.43391442 |
| 121 | JAK2 | 0.42859685 |
| 122 | TRPM7 | 0.42369598 |
| 123 | CCNB1 | 0.41725200 |
| 124 | IKBKB | 0.41586823 |
| 125 | LCK | 0.41442095 |
| 126 | STK38 | 0.41326535 |
| 127 | MAP3K14 | 0.40935658 |
| 128 | CSNK2A2 | 0.40660307 |
| 129 | GSK3B | 0.40199287 |
| 130 | GRK6 | 0.39799039 |
| 131 | AKT1 | 0.39650182 |
| 132 | CAMK4 | 0.39162135 |
| 133 | MAPK1 | 0.39097241 |
| 134 | PRKAA1 | 0.39009599 |
| 135 | PNCK | 0.35913808 |
| 136 | RPS6KB1 | 0.35723110 |
| 137 | PDGFRB | 0.34869100 |
| 138 | EIF2AK2 | 0.34786093 |
| 139 | HCK | 0.33361132 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 3.93333226 |
| 2 | Mismatch repair_Homo sapiens_hsa03430 | 3.66998693 |
| 3 | Cell cycle_Homo sapiens_hsa04110 | 2.92584522 |
| 4 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.71444305 |
| 5 | RNA transport_Homo sapiens_hsa03013 | 2.67556771 |
| 6 | Homologous recombination_Homo sapiens_hsa03440 | 2.67357498 |
| 7 | Base excision repair_Homo sapiens_hsa03410 | 2.52200791 |
| 8 | Spliceosome_Homo sapiens_hsa03040 | 2.49461240 |
| 9 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.47884406 |
| 10 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.47176945 |
| 11 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.45935197 |
| 12 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.18775706 |
| 13 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.90580348 |
| 14 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.89395483 |
| 15 | RNA degradation_Homo sapiens_hsa03018 | 1.76455022 |
| 16 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.71994740 |
| 17 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.71680075 |
| 18 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.53677864 |
| 19 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.48956954 |
| 20 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.45843961 |
| 21 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.45213304 |
| 22 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.44627293 |
| 23 | Basal transcription factors_Homo sapiens_hsa03022 | 1.42414946 |
| 24 | RNA polymerase_Homo sapiens_hsa03020 | 1.40107801 |
| 25 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 1.36193473 |
| 26 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.35765892 |
| 27 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 1.33482241 |
| 28 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.33338474 |
| 29 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.32942144 |
| 30 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.29605131 |
| 31 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 1.29485458 |
| 32 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.29440545 |
| 33 | Small cell lung cancer_Homo sapiens_hsa05222 | 1.27811701 |
| 34 | Glioma_Homo sapiens_hsa05214 | 1.26719888 |
| 35 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.24319174 |
| 36 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.21471397 |
| 37 | HTLV-I infection_Homo sapiens_hsa05166 | 1.21057469 |
| 38 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 1.20959702 |
| 39 | Ribosome_Homo sapiens_hsa03010 | 1.15258706 |
| 40 | Measles_Homo sapiens_hsa05162 | 1.13291132 |
| 41 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.09153906 |
| 42 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.09148380 |
| 43 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 1.07319255 |
| 44 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.06594120 |
| 45 | Renal cell carcinoma_Homo sapiens_hsa05211 | 1.06510219 |
| 46 | Hepatitis B_Homo sapiens_hsa05161 | 0.97082657 |
| 47 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.94289208 |
| 48 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.94127535 |
| 49 | Lysine degradation_Homo sapiens_hsa00310 | 0.93292966 |
| 50 | Viral myocarditis_Homo sapiens_hsa05416 | 0.92779265 |
| 51 | Colorectal cancer_Homo sapiens_hsa05210 | 0.91412199 |
| 52 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.91388703 |
| 53 | Apoptosis_Homo sapiens_hsa04210 | 0.89273456 |
| 54 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.88791182 |
| 55 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.85685030 |
| 56 | Olfactory transduction_Homo sapiens_hsa04740 | 0.85560119 |
| 57 | Influenza A_Homo sapiens_hsa05164 | 0.85438482 |
| 58 | Legionellosis_Homo sapiens_hsa05134 | 0.84774356 |
| 59 | Adherens junction_Homo sapiens_hsa04520 | 0.84530845 |
| 60 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.84470518 |
| 61 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.83512388 |
| 62 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.83210569 |
| 63 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.81169407 |
| 64 | Leishmaniasis_Homo sapiens_hsa05140 | 0.80654480 |
| 65 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.79444551 |
| 66 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.78405583 |
| 67 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.77160187 |
| 68 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.75834044 |
| 69 | Melanoma_Homo sapiens_hsa05218 | 0.75429156 |
| 70 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.75150721 |
| 71 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.72058571 |
| 72 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.72043430 |
| 73 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.71722336 |
| 74 | Prostate cancer_Homo sapiens_hsa05215 | 0.70113603 |
| 75 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.68896793 |
| 76 | Thyroid cancer_Homo sapiens_hsa05216 | 0.67844293 |
| 77 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.66210591 |
| 78 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.65871161 |
| 79 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.64841582 |
| 80 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.64661628 |
| 81 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.64619720 |
| 82 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.64346062 |
| 83 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.63368132 |
| 84 | Alcoholism_Homo sapiens_hsa05034 | 0.62711603 |
| 85 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.61929831 |
| 86 | Pathways in cancer_Homo sapiens_hsa05200 | 0.61900578 |
| 87 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.61575933 |
| 88 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.60553961 |
| 89 | Allograft rejection_Homo sapiens_hsa05330 | 0.60210198 |
| 90 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.60185855 |
| 91 | Circadian rhythm_Homo sapiens_hsa04710 | 0.59879547 |
| 92 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.59816243 |
| 93 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.59459668 |
| 94 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.59398084 |
| 95 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.58801157 |
| 96 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.58250930 |
| 97 | Shigellosis_Homo sapiens_hsa05131 | 0.57092314 |
| 98 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.56729469 |
| 99 | Purine metabolism_Homo sapiens_hsa00230 | 0.54949444 |
| 100 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.54885717 |
| 101 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.54601769 |
| 102 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.54448968 |
| 103 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.54248080 |
| 104 | ABC transporters_Homo sapiens_hsa02010 | 0.52896461 |
| 105 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.51505153 |
| 106 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.51442482 |
| 107 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.50554577 |
| 108 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.50392823 |
| 109 | Endometrial cancer_Homo sapiens_hsa05213 | 0.49485966 |
| 110 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.48630910 |
| 111 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.48098334 |
| 112 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.47974402 |
| 113 | Insulin resistance_Homo sapiens_hsa04931 | 0.46580980 |
| 114 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.43044915 |
| 115 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.41532724 |
| 116 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.41196339 |
| 117 | Proteasome_Homo sapiens_hsa03050 | 0.40849132 |
| 118 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.40507651 |
| 119 | Platelet activation_Homo sapiens_hsa04611 | 0.40193868 |
| 120 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.40081773 |
| 121 | Asthma_Homo sapiens_hsa05310 | 0.38813507 |
| 122 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.38257066 |
| 123 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.38140466 |
| 124 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.37889537 |
| 125 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.36909905 |
| 126 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.36697723 |
| 127 | Focal adhesion_Homo sapiens_hsa04510 | 0.35927115 |
| 128 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.35572642 |
| 129 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.35389182 |
| 130 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.34075475 |
| 131 | Bladder cancer_Homo sapiens_hsa05219 | 0.33815984 |
| 132 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.33254353 |
| 133 | Hepatitis C_Homo sapiens_hsa05160 | 0.32559844 |

