CEP250

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a core centrosomal protein required for centriole-centriole cohesion during interphase of the cell cycle. The encoded protein dissociates from the centrosomes when parental centrioles separate at the beginning of mitosis. The protein associates with and is phosphorylated by NIMA-related kinase 2, which is also associated with the centrosome. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of CREB transcription factor activity (GO:0032793)4.65864540
2positive regulation of gamma-delta T cell activation (GO:0046645)4.51017212
3corticosteroid receptor signaling pathway (GO:0031958)4.19729362
4negative regulation of cell killing (GO:0031342)4.06128613
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.06128613
6histone H3-K9 methylation (GO:0051567)4.00657805
7positive regulation of histone deacetylation (GO:0031065)3.77624302
8histone H3-K9 modification (GO:0061647)3.74466795
9regulation of gamma-delta T cell differentiation (GO:0045586)3.73844751
10positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.58911466
11chromosome condensation (GO:0030261)3.54071918
12DNA unwinding involved in DNA replication (GO:0006268)3.46672308
13positive thymic T cell selection (GO:0045059)3.46213973
14regulation of gamma-delta T cell activation (GO:0046643)3.43821546
15cell-cell junction maintenance (GO:0045217)3.43585311
16pre-miRNA processing (GO:0031054)3.43163813
17stress granule assembly (GO:0034063)3.42576198
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.39470978
19antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.39470978
20histone H3-K9 demethylation (GO:0033169)3.38918911
21nuclear pore complex assembly (GO:0051292)3.37470072
22regulation of hippo signaling (GO:0035330)3.37047982
23histone H3-K36 demethylation (GO:0070544)3.35605918
24regulation of histone H3-K27 methylation (GO:0061085)3.33461758
25embryonic retina morphogenesis in camera-type eye (GO:0060059)3.32858265
26sister chromatid segregation (GO:0000819)3.31113211
27dosage compensation (GO:0007549)3.30944297
28regulation of nucleobase-containing compound transport (GO:0032239)3.27034401
29positive regulation of B cell differentiation (GO:0045579)3.26583392
30negative regulation of histone methylation (GO:0031061)3.25581808
31regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.21826748
32B cell receptor signaling pathway (GO:0050853)3.20104235
33neural tube development (GO:0021915)3.19496080
34antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.19343701
35protein localization to kinetochore (GO:0034501)3.18415048
36mitotic sister chromatid cohesion (GO:0007064)3.17099103
37establishment of spindle localization (GO:0051293)3.15687155
38positive regulation by host of viral transcription (GO:0043923)3.14989293
39interkinetic nuclear migration (GO:0022027)3.14946183
40nuclear pore organization (GO:0006999)3.14774495
41antigen processing and presentation of endogenous antigen (GO:0019883)3.13457648
42monoubiquitinated protein deubiquitination (GO:0035520)3.13081712
43heterochromatin organization (GO:0070828)3.12108125
44DNA packaging (GO:0006323)3.12018389
45negative regulation of DNA-templated transcription, elongation (GO:0032785)3.08771259
46RNA localization (GO:0006403)3.03474052
47negative thymic T cell selection (GO:0045060)3.02241275
48negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.02168423
49intracellular estrogen receptor signaling pathway (GO:0030520)3.01716871
50mitotic sister chromatid segregation (GO:0000070)3.01642190
51regulation of B cell receptor signaling pathway (GO:0050855)3.00577792
52spliceosomal tri-snRNP complex assembly (GO:0000244)2.99878639
53DNA geometric change (GO:0032392)2.99205903
54DNA duplex unwinding (GO:0032508)2.99062972
55RNA stabilization (GO:0043489)2.99010815
56mRNA stabilization (GO:0048255)2.99010815
57negative T cell selection (GO:0043383)2.97526419
58positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.96671413
59DNA topological change (GO:0006265)2.96329976
60microtubule depolymerization (GO:0007019)2.95642384
61positive regulation of gene expression, epigenetic (GO:0045815)2.94046513
62mitotic chromosome condensation (GO:0007076)2.93513547
63thymic T cell selection (GO:0045061)2.90761183
64snRNA transcription (GO:0009301)2.90364965
65insulin-like growth factor receptor signaling pathway (GO:0048009)2.89909817
66regulation of ARF GTPase activity (GO:0032312)2.88891822
67positive regulation of protein deacetylation (GO:0090312)2.87346178
68natural killer cell differentiation (GO:0001779)2.85045423
69regulation of histone H3-K9 methylation (GO:0051570)2.84598624
70peptidyl-lysine dimethylation (GO:0018027)2.83619625
71regulation of histone methylation (GO:0031060)2.82712511
72regulation of histone H3-K4 methylation (GO:0051569)2.81540088
73regulation of B cell differentiation (GO:0045577)2.77862382
74positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.75884346
75mitotic G1 DNA damage checkpoint (GO:0031571)2.75159064
76positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.75083803
77positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.75083803
78positive regulation of mitotic sister chromatid separation (GO:1901970)2.75083803
79histone H3-K4 trimethylation (GO:0080182)2.75001611
80regulation of translational fidelity (GO:0006450)2.74022291
81positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.72909092
82negative regulation of phagocytosis (GO:0050765)2.72716517
83histone H3-K4 methylation (GO:0051568)2.71430020
84positive regulation of synapse maturation (GO:0090129)2.71281355
85chromatin assembly (GO:0031497)2.70139374
86body morphogenesis (GO:0010171)2.69603177
87histone H4 deacetylation (GO:0070933)2.69294565
88NLS-bearing protein import into nucleus (GO:0006607)2.68321795
89protein localization to chromosome, centromeric region (GO:0071459)2.67691663
90positive T cell selection (GO:0043368)2.67303843
91cell junction maintenance (GO:0034331)2.66740701
92glucocorticoid receptor signaling pathway (GO:0042921)2.66588007
93T cell selection (GO:0045058)2.66527469
94positive regulation of cell cycle checkpoint (GO:1901978)2.66371051
95mannose metabolic process (GO:0006013)2.65921020
96negative regulation of RNA splicing (GO:0033119)2.65669625
97histone methylation (GO:0016571)2.65063256
98cortical actin cytoskeleton organization (GO:0030866)2.64340999
99tolerance induction (GO:0002507)2.64138840
100negative regulation of granulocyte differentiation (GO:0030853)2.63209370
101regulation of interleukin-12 biosynthetic process (GO:0045075)2.63192360
102meiotic chromosome segregation (GO:0045132)2.61635299
103G1 DNA damage checkpoint (GO:0044783)2.61567136
104histone demethylation (GO:0016577)2.61429353
105activation of Rac GTPase activity (GO:0032863)2.61283237
106peptidyl-lysine methylation (GO:0018022)2.60512972
107establishment of spindle orientation (GO:0051294)2.60403322
108pore complex assembly (GO:0046931)2.60368642
109regulation of mitotic spindle organization (GO:0060236)2.59454976
110regulation of mammary gland epithelial cell proliferation (GO:0033599)2.58952776
111histone lysine demethylation (GO:0070076)2.58055788
112regulation of chromatin binding (GO:0035561)2.57975156
113receptor catabolic process (GO:0032801)2.57386671
114coronary vasculature morphogenesis (GO:0060977)2.56825201
115mitotic nuclear envelope disassembly (GO:0007077)2.55889647
116negative regulation of gene expression, epigenetic (GO:0045814)2.55310418
117antigen processing and presentation via MHC class Ib (GO:0002475)2.55104182
118histone mRNA catabolic process (GO:0071044)2.54745255
119peptidyl-lysine trimethylation (GO:0018023)2.53512693
120positive regulation of RNA splicing (GO:0033120)2.53399261
121protein-DNA complex disassembly (GO:0032986)2.52932342
122nucleosome disassembly (GO:0006337)2.52932342
123alternative mRNA splicing, via spliceosome (GO:0000380)2.52609876
124regulation of DNA endoreduplication (GO:0032875)2.52288752
125establishment of mitotic spindle localization (GO:0040001)2.51550694
126regulation of sister chromatid cohesion (GO:0007063)2.50646753
127chromatin silencing (GO:0006342)2.50326119
128establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.49904420
129mitochondrion transport along microtubule (GO:0047497)2.49904420
130histone phosphorylation (GO:0016572)2.49866018
131regulation of ARF protein signal transduction (GO:0032012)2.49814382
132regulation of RNA export from nucleus (GO:0046831)2.49403831
133histone deubiquitination (GO:0016578)2.49102186
134cytoplasmic mRNA processing body assembly (GO:0033962)2.48206523
135cell migration in hindbrain (GO:0021535)2.46956150
136negative regulation of mRNA processing (GO:0050686)2.46297868
137positive regulation of chromosome segregation (GO:0051984)2.45792004
138negative regulation of sodium ion transport (GO:0010766)2.45508059
139positive regulation of Rab GTPase activity (GO:0032851)2.45139322
140regulation of Rab GTPase activity (GO:0032313)2.45139322
141DNA synthesis involved in DNA repair (GO:0000731)2.44259439
142microtubule nucleation (GO:0007020)2.44044115
143translesion synthesis (GO:0019985)2.43510238
144histone H4-K16 acetylation (GO:0043984)2.42796042
145membrane disassembly (GO:0030397)2.42499026
146nuclear envelope disassembly (GO:0051081)2.42499026
147cellular response to virus (GO:0098586)2.41356473
148protein hydroxylation (GO:0018126)2.40948268
149lung epithelium development (GO:0060428)2.40137932
150morphogenesis of an endothelium (GO:0003159)2.39272908
151endothelial tube morphogenesis (GO:0061154)2.39272908
152semaphorin-plexin signaling pathway (GO:0071526)2.38996475
153protein demethylation (GO:0006482)2.38251328
154protein dealkylation (GO:0008214)2.38251328
155positive regulation by symbiont of host defense response (GO:0052509)2.38119047
156modulation by symbiont of host defense response (GO:0052031)2.38119047
157modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.38119047
158modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.38119047
159positive regulation by organism of defense response of other organism involved in symbiotic interact2.38119047
160modulation by symbiont of host immune response (GO:0052553)2.38119047
161negative regulation of mRNA metabolic process (GO:1903312)2.36769355
162DNA conformation change (GO:0071103)2.35069207
163negative regulation of erythrocyte differentiation (GO:0045647)2.34609624
164regulation of interferon-beta biosynthetic process (GO:0045357)2.33994535
165histone lysine methylation (GO:0034968)2.32408841
166regulation of integrin activation (GO:0033623)2.30364222
167negative regulation of B cell proliferation (GO:0030889)2.28361503
168mitotic G1/S transition checkpoint (GO:0044819)2.28055289
169interferon-gamma production (GO:0032609)2.27822374
170regulation of NFAT protein import into nucleus (GO:0051532)2.27469083

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.61049216
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.88570813
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.32742165
4MYC_22102868_ChIP-Seq_BL_Human4.04005405
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.44055708
6VDR_21846776_ChIP-Seq_THP-1_Human3.17020065
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.97017385
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.64793351
9TCF7_22412390_ChIP-Seq_EML_Mouse2.59139160
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.50864632
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.43123074
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.40861606
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.40461380
14* KDM2B_26808549_Chip-Seq_DND41_Human2.23733336
15CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.23540630
16DROSHA_22980978_ChIP-Seq_HELA_Human2.23455545
17KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.22589038
18MAF_26560356_Chip-Seq_TH1_Human2.21258453
19KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.20539387
20UTX_26944678_Chip-Seq_JUKART_Human2.14633766
21KDM2B_26808549_Chip-Seq_SUP-B15_Human2.13213594
22ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.02667619
23SCL_19346495_ChIP-Seq_HPC-7_Human2.01265320
24SMC4_20622854_ChIP-Seq_HELA_Human2.00919873
25TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.99013217
26ELK3_25401928_ChIP-Seq_HUVEC_Human1.97774708
27P68_20966046_ChIP-Seq_HELA_Human1.93517692
28HIF1A_21447827_ChIP-Seq_MCF-7_Human1.91687336
29VDR_24763502_ChIP-Seq_THP-1_Human1.91329183
30ESR1_15608294_ChIP-ChIP_MCF-7_Human1.90725319
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.90507766
32SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.89566686
33MYB_26560356_Chip-Seq_TH2_Human1.89142323
34MYB_26560356_Chip-Seq_TH1_Human1.85053370
35IRF8_21731497_ChIP-ChIP_J774_Mouse1.84147569
36MYB_21317192_ChIP-Seq_ERMYB_Mouse1.83881752
37FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.83531658
38NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.82672149
39* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.82669950
40FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.80377398
41CIITA_25753668_ChIP-Seq_RAJI_Human1.77236774
42IRF8_27001747_Chip-Seq_BMDM_Mouse1.75005400
43* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.74394453
44SPI1_23127762_ChIP-Seq_K562_Human1.72543690
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.68829183
46RUNX1_22412390_ChIP-Seq_EML_Mouse1.66962148
47MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.63753761
48* FOXA2_19822575_ChIP-Seq_HepG2_Human1.63288993
49STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.62584271
50TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62169841
51IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.56338024
52RUNX_20019798_ChIP-Seq_JUKART_Human1.56046472
53E2F1_21310950_ChIP-Seq_MCF-7_Human1.54250989
54MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.51680153
55SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.50714277
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.48770149
57RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.48539982
58KDM2B_26808549_Chip-Seq_JURKAT_Human1.47349195
59TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.46336350
60CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.45778558
61SPI1_23547873_ChIP-Seq_NB4_Human1.45244927
62MAF_26560356_Chip-Seq_TH2_Human1.40816818
63EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.40522590
64SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.37593001
65NCOR1_26117541_ChIP-Seq_K562_Human1.37288032
66KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.37202087
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.36506096
68RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.35410564
69ZFP281_27345836_Chip-Seq_ESCs_Mouse1.32949462
70STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.32380391
71TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.31148679
72* CREB1_26743006_Chip-Seq_LNCaP_Human1.30063831
73BCOR_27268052_Chip-Seq_Bcells_Human1.29080458
74PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28239107
75TP63_17297297_ChIP-ChIP_HaCaT_Human1.27867247
76DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.26474147
77RARB_27405468_Chip-Seq_BRAIN_Mouse1.26410532
78EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26214158
79LXR_22292898_ChIP-Seq_THP-1_Human1.25328754
80IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.24499836
81KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.24236630
82TP53_23651856_ChIP-Seq_MEFs_Mouse1.23451282
83RUNX1_27514584_Chip-Seq_MCF-7_Human1.23265120
84CTNNB1_20460455_ChIP-Seq_HCT116_Human1.23173430
85ELF1_20517297_ChIP-Seq_JURKAT_Human1.21870944
86P300_27058665_Chip-Seq_ZR-75-30cells_Human1.19564173
87VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19063139
88RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.18490580
89STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18127812
90STAT4_19710469_ChIP-ChIP_TH1__Mouse1.18033887
91MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.17224444
92PHF8_20622854_ChIP-Seq_HELA_Human1.16687444
93EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.15983442
94* MITF_21258399_ChIP-Seq_MELANOMA_Human1.15810288
95TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.15332452
96AR_21572438_ChIP-Seq_LNCaP_Human1.14762866
97TP63_19390658_ChIP-ChIP_HaCaT_Human1.13920547
98UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13710866
99SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12821183
100* BCL6_27268052_Chip-Seq_Bcells_Human1.11282294
101RARA_24833708_ChIP-Seq_LIVER_Mouse1.09232085
102CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09198466
103KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06796223
104CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06631707
105OCT4_19829295_ChIP-Seq_ESCs_Human1.06121295
106NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.05641795
107TET1_21451524_ChIP-Seq_MESCs_Mouse1.05221432
108E2F1_20622854_ChIP-Seq_HELA_Human1.04938097
109SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.04379424
110ZNF263_19887448_ChIP-Seq_K562_Human1.04338921
111GATA1_22383799_ChIP-Seq_G1ME_Mouse1.03754705
112TFEB_21752829_ChIP-Seq_HELA_Human1.03675979
113FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.03381661
114PU_27001747_Chip-Seq_BMDM_Mouse1.03376642
115KDM2B_26808549_Chip-Seq_K562_Human1.02864000
116TP63_22573176_ChIP-Seq_HFKS_Human1.01185293
117FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.01005459
118ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00998715
119UBF1/2_26484160_Chip-Seq_HMECs_Human0.99500177
120CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.99291505
121GATA3_27048872_Chip-Seq_THYMUS_Human0.99009933
122TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.98439742
123WDR5_24793694_ChIP-Seq_LNCAP_Human0.97428912
124RACK7_27058665_Chip-Seq_MCF-7_Human0.96689010
125ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96378434
126TP53_22127205_ChIP-Seq_IMR90_Human0.95655462
127GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95561120
128ZFP281_18757296_ChIP-ChIP_E14_Mouse0.95554848
129* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95429152
130GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95100798
131SOX9_24532713_ChIP-Seq_HFSC_Mouse0.94966721
132PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94616261
133AR_21909140_ChIP-Seq_LNCAP_Human0.94005319
134KDM5A_27292631_Chip-Seq_BREAST_Human0.93970053
135* GATA1_19941827_ChIP-Seq_MEL_Mouse0.93643402
136NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.93121612
137FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93099004
138CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91626970
139SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.91450557
140BP1_19119308_ChIP-ChIP_Hs578T_Human0.87989033
141MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.84901481
142GATA1_19941826_ChIP-Seq_K562_Human0.84683938
143ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.83708920
144ATF3_27146783_Chip-Seq_COLON_Human0.83472922
145* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81705988
146* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81402004
147* PKCTHETA_26484144_Chip-Seq_BREAST_Human0.80546984
148NFIB_24661679_ChIP-Seq_LUNG_Mouse0.79032871
149WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.78569310
150KLF4_18555785_ChIP-Seq_MESCs_Mouse0.77993033

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.54051374
2MP0003705_abnormal_hypodermis_morpholog3.37981488
3MP0003122_maternal_imprinting3.26105893
4MP0009278_abnormal_bone_marrow2.96399966
5MP0003303_peritoneal_inflammation2.70863988
6MP0010352_gastrointestinal_tract_polyps2.69798459
7MP0003300_gastrointestinal_ulcer2.66966931
8MP0005076_abnormal_cell_differentiation2.62916238
9MP0004808_abnormal_hematopoietic_stem2.62333152
10MP0002396_abnormal_hematopoietic_system2.61718599
11MP0002089_abnormal_postnatal_growth/wei2.54735152
12MP0003878_abnormal_ear_physiology2.53501704
13MP0005377_hearing/vestibular/ear_phenot2.53501704
14MP0010307_abnormal_tumor_latency2.46680289
15MP0001348_abnormal_lacrimal_gland2.45695753
16MP0000685_abnormal_immune_system2.33508923
17MP0005409_darkened_coat_color2.20270692
18MP0001835_abnormal_antigen_presentation2.13707387
19MP0003123_paternal_imprinting2.09531250
20MP0003111_abnormal_nucleus_morphology2.08249327
21MP0001800_abnormal_humoral_immune2.07187469
22MP0002398_abnormal_bone_marrow1.95720865
23MP0010094_abnormal_chromosome_stability1.95129993
24MP0002166_altered_tumor_susceptibility1.92857098
25MP0005397_hematopoietic_system_phenotyp1.88883625
26MP0001545_abnormal_hematopoietic_system1.88883625
27MP0008438_abnormal_cutaneous_collagen1.83649736
28MP0004859_abnormal_synaptic_plasticity1.81888846
29MP0001790_abnormal_immune_system1.80000880
30MP0005387_immune_system_phenotype1.80000880
31MP0003566_abnormal_cell_adhesion1.79343115
32MP0000703_abnormal_thymus_morphology1.78168587
33MP0004858_abnormal_nervous_system1.76964888
34MP0002452_abnormal_antigen_presenting1.76007058
35MP0003763_abnormal_thymus_physiology1.75593473
36MP0005451_abnormal_body_composition1.75467975
37MP0003077_abnormal_cell_cycle1.75401956
38MP0003436_decreased_susceptibility_to1.74374596
39MP0000003_abnormal_adipose_tissue1.74059602
40MP0003115_abnormal_respiratory_system1.69757952
41MP0003329_amyloid_beta_deposits1.65813943
42MP0002722_abnormal_immune_system1.63542731
43MP0002420_abnormal_adaptive_immunity1.61688405
44MP0003172_abnormal_lysosome_physiology1.60939659
45MP0000689_abnormal_spleen_morphology1.60464006
46MP0005257_abnormal_intraocular_pressure1.59952893
47MP0001819_abnormal_immune_cell1.59146446
48MP0000716_abnormal_immune_system1.55351123
49MP0009333_abnormal_splenocyte_physiolog1.51684978
50MP0000733_abnormal_muscle_development1.50402721
51MP0005174_abnormal_tail_pigmentation1.50104200
52MP0002405_respiratory_system_inflammati1.49699631
53MP0002723_abnormal_immune_serum1.49219010
54MP0002006_tumorigenesis1.45885160
55MP0005464_abnormal_platelet_physiology1.43279350
56MP0005000_abnormal_immune_tolerance1.43272905
57MP0004185_abnormal_adipocyte_glucose1.42846885
58MP0005671_abnormal_response_to1.39513531
59MP0000350_abnormal_cell_proliferation1.38570160
60MP0002429_abnormal_blood_cell1.37405274
61MP0003632_abnormal_nervous_system1.37285103
62MP0008057_abnormal_DNA_replication1.37248368
63MP0004947_skin_inflammation1.35334572
64MP0003950_abnormal_plasma_membrane1.34861979
65MP0008961_abnormal_basal_metabolism1.34270427
66MP0003693_abnormal_embryo_hatching1.33566036
67MP0004742_abnormal_vestibular_system1.33267360
68MP0003279_aneurysm1.29727973
69MP0000465_gastrointestinal_hemorrhage1.28578066
70MP0005023_abnormal_wound_healing1.27622407
71MP0002419_abnormal_innate_immunity1.27219551
72MP0003943_abnormal_hepatobiliary_system1.27182352
73MP0001873_stomach_inflammation1.27085031
74MP0003091_abnormal_cell_migration1.26694468
75MP0001730_embryonic_growth_arrest1.26679379
76MP0000490_abnormal_crypts_of1.25796785
77MP0000778_abnormal_nervous_system1.25771649
78MP0003385_abnormal_body_wall1.25596042
79MP0008007_abnormal_cellular_replicative1.23721269
80MP0003861_abnormal_nervous_system1.22985490
81MP0001915_intracranial_hemorrhage1.22612620
82MP0000678_abnormal_parathyroid_gland1.21681413
83MP0003183_abnormal_peptide_metabolism1.20779201
84MP0005025_abnormal_response_to1.19340617
85MP0003045_fibrosis1.19083692
86MP0004233_abnormal_muscle_weight1.19017469
87MP0003448_altered_tumor_morphology1.18412452
88MP0003879_abnormal_hair_cell1.17205683
89MP0003787_abnormal_imprinting1.15622553
90MP0004197_abnormal_fetal_growth/weight/1.13356820
91MP0010155_abnormal_intestine_physiology1.13333407
92MP0002086_abnormal_extraembryonic_tissu1.12688332
93MP0004957_abnormal_blastocyst_morpholog1.12095348
94MP0002019_abnormal_tumor_incidence1.10245572
95MP0004130_abnormal_muscle_cell1.10151558
96MP0003942_abnormal_urinary_system1.08188880
97MP0002009_preneoplasia1.07393937
98MP0001958_emphysema1.06664577
99MP0006082_CNS_inflammation1.05355964
100MP0002970_abnormal_white_adipose1.03679129
101MP0003984_embryonic_growth_retardation1.03595161
102MP0002877_abnormal_melanocyte_morpholog1.03198476
103MP0000858_altered_metastatic_potential1.02958668
104MP0001672_abnormal_embryogenesis/_devel1.02733134
105MP0005380_embryogenesis_phenotype1.02733134
106MP0002088_abnormal_embryonic_growth/wei1.02374650
107MP0000955_abnormal_spinal_cord1.02044552
108MP0002152_abnormal_brain_morphology1.00278467
109MP0000371_diluted_coat_color0.99896865
110MP0008770_decreased_survivor_rate0.98367324
111MP0005058_abnormal_lysosome_morphology0.97832285
112MP0002092_abnormal_eye_morphology0.94027608
113MP0000428_abnormal_craniofacial_morphol0.93614025
114MP0002925_abnormal_cardiovascular_devel0.93068886
115MP0002933_joint_inflammation0.93036542
116MP0002080_prenatal_lethality0.92816291
117MP0001697_abnormal_embryo_size0.92407597
118MP0002084_abnormal_developmental_patter0.91878014
119MP0001849_ear_inflammation0.91814154
120MP0000313_abnormal_cell_death0.91030404
121MP0005384_cellular_phenotype0.91022532
122MP0004381_abnormal_hair_follicle0.90689787
123MP0004811_abnormal_neuron_physiology0.90172090
124MP0005621_abnormal_cell_physiology0.87655485
125MP0009115_abnormal_fat_cell0.87508127
126MP0000767_abnormal_smooth_muscle0.85183323
127MP0010234_abnormal_vibrissa_follicle0.84750761
128MP0004510_myositis0.83867858
129MP0001845_abnormal_inflammatory_respons0.83379802
130MP0002085_abnormal_embryonic_tissue0.83160169
131MP0002075_abnormal_coat/hair_pigmentati0.82405932
132MP0002184_abnormal_innervation0.82027806
133MP0002882_abnormal_neuron_morphology0.81620473
134MP0000015_abnormal_ear_pigmentation0.80177697
135MP0001270_distended_abdomen0.79851630
136MP0003698_abnormal_male_reproductive0.79341372
137MP0003866_abnormal_defecation0.78860095
138MP0009785_altered_susceptibility_to0.78546259
139MP0002928_abnormal_bile_duct0.78232139
140MP0005423_abnormal_somatic_nervous0.77707090
141MP0005375_adipose_tissue_phenotype0.77257493
142MP0002735_abnormal_chemical_nociception0.77037174
143MP0005171_absent_coat_pigmentation0.76760509
144MP0005310_abnormal_salivary_gland0.76759215
145MP0001533_abnormal_skeleton_physiology0.76705189
146MP0002116_abnormal_craniofacial_bone0.76545258
147MP0002697_abnormal_eye_size0.75907971
148MP0003121_genomic_imprinting0.75557518
149MP0004043_abnormal_pH_regulation0.75458313
150MP0003948_abnormal_gas_homeostasis0.75369948
151MP0002998_abnormal_bone_remodeling0.73003688
152MP0000432_abnormal_head_morphology0.72465626
153MP0006054_spinal_hemorrhage0.72275594
154MP0005220_abnormal_exocrine_pancreas0.71973657
155MP0005623_abnormal_meninges_morphology0.71691799
156MP0000358_abnormal_cell_content/0.71619026

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)3.70493835
2Cerebral aneurysm (HP:0004944)3.53959161
3Hyperacusis (HP:0010780)3.30160868
4Cellulitis (HP:0100658)2.90203620
5Deep venous thrombosis (HP:0002625)2.86245567
6Ulnar bowing (HP:0003031)2.77152400
7Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.75308278
8Dislocated radial head (HP:0003083)2.74833068
9Recurrent viral infections (HP:0004429)2.69372983
10Genetic anticipation (HP:0003743)2.67129323
11Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.65940633
12Short 4th metacarpal (HP:0010044)2.65940633
13High pitched voice (HP:0001620)2.65533708
14Abnormality of the radial head (HP:0003995)2.65277378
15Long eyelashes (HP:0000527)2.65030108
16Protrusio acetabuli (HP:0003179)2.61632325
17Chromosomal breakage induced by crosslinking agents (HP:0003221)2.55372177
18Increased density of long bones (HP:0006392)2.53523424
19Obsessive-compulsive behavior (HP:0000722)2.51265890
20Recurrent fungal infections (HP:0002841)2.46676804
21Dysmetric saccades (HP:0000641)2.46514166
22Flat acetabular roof (HP:0003180)2.45408100
23Supernumerary ribs (HP:0005815)2.44918984
24Broad face (HP:0000283)2.44114255
25Morphological abnormality of the middle ear (HP:0008609)2.42097441
26Truncal obesity (HP:0001956)2.34667409
27Shallow orbits (HP:0000586)2.31948083
28Supernumerary bones of the axial skeleton (HP:0009144)2.31506972
29Facial hemangioma (HP:0000329)2.29924166
30Colitis (HP:0002583)2.28953165
3111 pairs of ribs (HP:0000878)2.27678328
32T lymphocytopenia (HP:0005403)2.27451569
33Macroorchidism (HP:0000053)2.27178854
34Chromsome breakage (HP:0040012)2.26643840
35Recurrent abscess formation (HP:0002722)2.24671695
36Autoimmune thrombocytopenia (HP:0001973)2.24277561
37Deep palmar crease (HP:0006191)2.24153718
38Aortic aneurysm (HP:0004942)2.22560877
39Panhypogammaglobulinemia (HP:0003139)2.21920436
40Gastrointestinal inflammation (HP:0004386)2.21042902
41Eczematoid dermatitis (HP:0000976)2.20871463
42Hypoplasia of the capital femoral epiphysis (HP:0003090)2.20624738
43Papilloma (HP:0012740)2.18085120
44Verrucae (HP:0200043)2.18085120
45Thin bony cortex (HP:0002753)2.17953475
46Abnormality of the nasal septum (HP:0000419)2.17609743
47Vertebral arch anomaly (HP:0008438)2.16690767
48Small epiphyses (HP:0010585)2.15808253
49Abnormality of the ischium (HP:0003174)2.15068507
50Prominent nose (HP:0000448)2.14602319
51Inflammation of the large intestine (HP:0002037)2.14403271
52Abnormality of DNA repair (HP:0003254)2.13614924
53Absent frontal sinuses (HP:0002688)2.12216693
54Tapered finger (HP:0001182)2.11339890
55Hematochezia (HP:0002573)2.10821852
56Agammaglobulinemia (HP:0004432)2.10653935
57Heterotopia (HP:0002282)2.09627833
58Abnormality of T cell number (HP:0011839)2.09541292
59Hypoplastic ischia (HP:0003175)2.08826140
60Poikiloderma (HP:0001029)2.07203734
61Abnormality of the aortic arch (HP:0012303)2.05506014
62Patellar aplasia (HP:0006443)2.04062220
63Increased nuchal translucency (HP:0010880)2.03720157
64Thyroiditis (HP:0100646)2.03657484
65Aplasia/Hypoplasia of the sternum (HP:0006714)2.03383287
66Protruding tongue (HP:0010808)2.03303746
67Broad alveolar ridges (HP:0000187)2.02954705
68Bowel diverticulosis (HP:0005222)2.02640125
69Abnormal delayed hypersensitivity skin test (HP:0002963)2.02115379
70Radial bowing (HP:0002986)2.01484414
71Elfin facies (HP:0004428)2.01266570
72Recurrent bronchitis (HP:0002837)1.99588717
73Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.99034256
74Absent epiphyses (HP:0010577)1.99034256
75Renovascular hypertension (HP:0100817)1.98489626
76Dilatation of the ascending aorta (HP:0005111)1.97363102
77Spina bifida occulta (HP:0003298)1.97351367
78Volvulus (HP:0002580)1.93746290
79Smooth philtrum (HP:0000319)1.93365704
80Abnormality of the pubic bones (HP:0003172)1.92832598
81Patellar dislocation (HP:0002999)1.91791514
82Wrist flexion contracture (HP:0001239)1.91605246
83Recurrent bacterial skin infections (HP:0005406)1.90749682
84Tibial bowing (HP:0002982)1.90249381
85Mitral valve prolapse (HP:0001634)1.90066886
86Urethral obstruction (HP:0000796)1.89965647
87Narrow palate (HP:0000189)1.88882027
88Thick eyebrow (HP:0000574)1.88726657
89Broad palm (HP:0001169)1.88674620
90B lymphocytopenia (HP:0010976)1.87938892
91Abnormality of B cell number (HP:0010975)1.87938892
92Hemorrhage of the eye (HP:0011885)1.87320999
93Disproportionate tall stature (HP:0001519)1.87140418
94Bronchomalacia (HP:0002780)1.86742033
95Acute lymphatic leukemia (HP:0006721)1.86451320
96Asymmetry of the thorax (HP:0001555)1.85381101
97Aplasia/Hypoplasia of the patella (HP:0006498)1.85079294
98Skull defect (HP:0001362)1.84410289
99Renal duplication (HP:0000075)1.83587726
100Bowing of the arm (HP:0006488)1.82395758
101Bowed forearm bones (HP:0003956)1.82395758
102Syringomyelia (HP:0003396)1.82021723
103Spinal cord lesions (HP:0100561)1.82021723
104Basal cell carcinoma (HP:0002671)1.81818609
105Deviation of the thumb (HP:0009603)1.80765715
106Abnormality of the 4th metacarpal (HP:0010012)1.80641665
107Osteomyelitis (HP:0002754)1.79873085
108Spontaneous hematomas (HP:0007420)1.79645366
109Subacute progressive viral hepatitis (HP:0006572)1.79130050
110IgM deficiency (HP:0002850)1.78906384
111Chronic otitis media (HP:0000389)1.78788586
112Chronic mucocutaneous candidiasis (HP:0002728)1.78615251
113Recurrent cutaneous fungal infections (HP:0011370)1.78615251
114Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.77369153
115Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.77102035
116Pointed chin (HP:0000307)1.77067061
117Meningitis (HP:0001287)1.76394253
118Cupped ribs (HP:0000887)1.76135476
119Proximal placement of thumb (HP:0009623)1.76066910
120High anterior hairline (HP:0009890)1.75431666
121Bicuspid aortic valve (HP:0001647)1.75045294
122Abnormality of the humeroradial joint (HP:0100744)1.75008388
123Nasal polyposis (HP:0100582)1.74544488
124Genu recurvatum (HP:0002816)1.73674059
125Limited elbow extension (HP:0001377)1.73116333
126Biconcave vertebral bodies (HP:0004586)1.72936408
127Ankle contracture (HP:0006466)1.72792743
128Osteolytic defects of the hand bones (HP:0009699)1.72725167
129Osteolytic defects of the phalanges of the hand (HP:0009771)1.72725167
130Abnormality of the thoracic spine (HP:0100711)1.72561507
131Myositis (HP:0100614)1.72493685
132Cutis marmorata (HP:0000965)1.72454747
133Bladder diverticulum (HP:0000015)1.71162562
134Ectopic kidney (HP:0000086)1.71039614
135Tented upper lip vermilion (HP:0010804)1.69527498
136Neonatal short-limb short stature (HP:0008921)1.69311084
137Supernumerary nipples (HP:0002558)1.69310149
138Spondylolisthesis (HP:0003302)1.69088522
139Pustule (HP:0200039)1.69009718
140Insomnia (HP:0100785)1.68343926
141Trigonocephaly (HP:0000243)1.67957164
142Aneurysm (HP:0002617)1.67821639
143Hypopigmentation of the fundus (HP:0007894)1.67709228
144Abnormality of T cells (HP:0002843)1.67123119
145Abnormal platelet volume (HP:0011876)1.65253122
146Skin tags (HP:0010609)1.65150407
147Broad metatarsal (HP:0001783)1.64861592
148Thrombocytosis (HP:0001894)1.64497855
149Onion bulb formation (HP:0003383)1.63861733
150Synophrys (HP:0000664)1.63543620
151Flat cornea (HP:0007720)1.63054708
152Diastasis recti (HP:0001540)1.62129704
153Hand muscle atrophy (HP:0009130)1.62067938
154Wide nose (HP:0000445)1.62058599
155Capillary hemangiomas (HP:0005306)1.61895912
156Submucous cleft hard palate (HP:0000176)1.61352762
157Abnormality of the nasal mucosa (HP:0000433)1.61331423
158Abnormality of dentin (HP:0010299)1.60274025
159Attention deficit hyperactivity disorder (HP:0007018)1.60162129
160Distal upper limb amyotrophy (HP:0007149)1.60126809
161Upper limb amyotrophy (HP:0009129)1.60126809
162Chronic hepatic failure (HP:0100626)1.59273007
163Abnormality of the peritoneum (HP:0002585)1.59255646
164Neoplasm of the oral cavity (HP:0100649)1.59053165
165Low anterior hairline (HP:0000294)1.58455519
166Long clavicles (HP:0000890)1.58197013
167Abnormality of the calcaneus (HP:0008364)1.58010191
168Self-mutilation (HP:0000742)1.57996014
169Mild short stature (HP:0003502)1.56426806
170Sandal gap (HP:0001852)1.55388728
171Overlapping toe (HP:0001845)1.53612064
172Urinary bladder sphincter dysfunction (HP:0002839)1.51340852
173Abnormality of the wing of the ilium (HP:0011867)1.50781469
174Cerebral inclusion bodies (HP:0100314)1.50401563

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K104.08894992
2EEF2K3.81732321
3CDK123.53242887
4PKN23.16101947
5MAP4K13.14693080
6TRIB33.07073841
7CDC72.14649522
8TTN2.11384428
9SCYL22.11375932
10ERN11.99232694
11STK101.90189371
12SMG11.90162865
13RIPK11.79788060
14CAMK1D1.71745894
15WNK41.70902045
16TYK21.64825543
17* NEK21.61154876
18PTK61.59791368
19CAMK1G1.53562459
20MST1R1.48991541
21BRD41.43892823
22JAK11.39313969
23CDK41.38885327
24CDK61.37458582
25GRK61.37400435
26CSF1R1.32155853
27PDGFRA1.29419860
28LRRK21.27846765
29NTRK11.26857380
30JAK31.25682787
31HCK1.24572721
32WNK11.23756122
33ALK1.23009232
34STK381.22000605
35ZAP701.19312019
36* SIK21.16953469
37BTK1.16541086
38MTOR1.15157058
39CSK1.14875198
40KIT1.13203019
41FGFR31.12580676
42NTRK21.11209832
43PRPF4B1.08603055
44PRKD31.06997104
45BMX1.04590980
46NEK11.04438146
47STK41.03411182
48LATS11.03303245
49ITK1.01310803
50SIK11.00860031
51ATR0.99930977
52TGFBR20.98795984
53RPS6KB20.93042752
54ICK0.89658210
55PAK40.89590243
56CLK10.89540159
57SYK0.89216454
58PDGFRB0.88457639
59RPS6KA40.88213683
60FGFR40.88023374
61FES0.87779963
62PIM10.86718364
63LCK0.82573854
64PRKCH0.78538370
65MAP3K80.76660794
66MAP3K70.74679578
67IRAK30.74030002
68MAP3K130.73400019
69CDK10.70737157
70MARK30.70698135
71STK30.70129662
72TRPM70.69602732
73CHEK10.69029264
74MET0.68834281
75FRK0.68375287
76RIPK40.67100900
77CASK0.66923287
78MAP2K30.66527841
79CDK90.66301803
80SGK30.65976452
81MAPK110.65943534
82MAPK100.65691133
83RPS6KA20.65251012
84MAP3K90.64726523
85MOS0.64458354
86SGK2230.64062903
87SGK4940.64062903
88TNK20.63280121
89FLT30.62361901
90PAK20.62116923
91CHUK0.61626676
92HIPK20.61494000
93JAK20.60660039
94EPHB10.59199977
95TTK0.58081498
96CDK20.57982713
97BCR0.55016738
98MARK20.54823981
99TBK10.54822179
100EPHA20.54773730
101CDK70.54713904
102MARK10.53901284
103FGFR20.53714064
104GSK3B0.53676680
105ATM0.53646011
106TNIK0.52570206
107TAOK10.51869115
108TXK0.51694768
109PDK10.51584864
110TAOK30.51511919
111PDPK10.50263008
112PRKAA10.48789384
113DYRK1B0.48642764
114AURKB0.48071491
115TLK10.47795405
116AKT10.47605048
117BLK0.47431894
118MAPK80.47273356
119TYRO30.46650507
120SIK30.45999909
121TGFBR10.45135776
122CAMKK10.44771050
123PRKD20.44157073
124TEC0.43814418
125RET0.43587582
126LYN0.43424295
127RPS6KA60.42953698
128MAP3K140.42555629
129CDC42BPA0.41573314
130BRSK10.40763600
131RPS6KB10.40333107
132MELK0.40178221
133MAPK10.39909643
134EGFR0.39399977
135NEK90.39102437
136PASK0.38675471
137SGK20.38291105
138CHEK20.38277690
139MAPK140.38097556
140MATK0.37791914
141PAK60.37701419
142PTK20.37537423
143SGK10.37197598
144RPS6KL10.36769869
145RPS6KC10.36769869
146ERBB20.36126032
147MAP2K70.36091421
148FGFR10.35024937

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.27026942
2B cell receptor signaling pathway_Homo sapiens_hsa046622.20946197
3Chronic myeloid leukemia_Homo sapiens_hsa052201.96624617
4Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.75703354
5Osteoclast differentiation_Homo sapiens_hsa043801.65216441
6DNA replication_Homo sapiens_hsa030301.62916219
7Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.61765458
8Leishmaniasis_Homo sapiens_hsa051401.51571870
9Lysine degradation_Homo sapiens_hsa003101.49527078
10Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.48092886
11Small cell lung cancer_Homo sapiens_hsa052221.45864804
12Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.41710829
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.40858773
14Notch signaling pathway_Homo sapiens_hsa043301.40854805
15Non-small cell lung cancer_Homo sapiens_hsa052231.40810058
16Antigen processing and presentation_Homo sapiens_hsa046121.37676013
17T cell receptor signaling pathway_Homo sapiens_hsa046601.36791312
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.36393338
19MicroRNAs in cancer_Homo sapiens_hsa052061.36018943
20mTOR signaling pathway_Homo sapiens_hsa041501.30278179
21Base excision repair_Homo sapiens_hsa034101.29445078
22Measles_Homo sapiens_hsa051621.29194856
23Cell cycle_Homo sapiens_hsa041101.27515509
24Pancreatic cancer_Homo sapiens_hsa052121.26685915
25ErbB signaling pathway_Homo sapiens_hsa040121.25074124
26Acute myeloid leukemia_Homo sapiens_hsa052211.24784272
27Toxoplasmosis_Homo sapiens_hsa051451.23533656
28Hepatitis B_Homo sapiens_hsa051611.21067680
29Leukocyte transendothelial migration_Homo sapiens_hsa046701.21002595
30HTLV-I infection_Homo sapiens_hsa051661.20015966
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.19296344
32Apoptosis_Homo sapiens_hsa042101.19238555
33Proteoglycans in cancer_Homo sapiens_hsa052051.17213976
34Viral myocarditis_Homo sapiens_hsa054161.16679112
35Viral carcinogenesis_Homo sapiens_hsa052031.16225329
36Neurotrophin signaling pathway_Homo sapiens_hsa047221.15927027
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.15792774
38Platelet activation_Homo sapiens_hsa046111.14256172
39ABC transporters_Homo sapiens_hsa020101.12110738
40Herpes simplex infection_Homo sapiens_hsa051681.11983868
41Transcriptional misregulation in cancer_Homo sapiens_hsa052021.11978303
42Colorectal cancer_Homo sapiens_hsa052101.10656947
43Chemokine signaling pathway_Homo sapiens_hsa040621.10618948
44Fructose and mannose metabolism_Homo sapiens_hsa000511.10596293
45Mismatch repair_Homo sapiens_hsa034301.10001028
46Glioma_Homo sapiens_hsa052141.09911874
47mRNA surveillance pathway_Homo sapiens_hsa030151.07548016
48Thyroid hormone signaling pathway_Homo sapiens_hsa049191.06974954
49p53 signaling pathway_Homo sapiens_hsa041151.05556302
50Fatty acid biosynthesis_Homo sapiens_hsa000611.05459863
51Hematopoietic cell lineage_Homo sapiens_hsa046401.05215952
52Jak-STAT signaling pathway_Homo sapiens_hsa046301.00569341
53Tuberculosis_Homo sapiens_hsa051521.00154885
54Non-homologous end-joining_Homo sapiens_hsa034500.99878190
55Shigellosis_Homo sapiens_hsa051310.99517994
56Choline metabolism in cancer_Homo sapiens_hsa052310.98492369
57Focal adhesion_Homo sapiens_hsa045100.98024273
58Spliceosome_Homo sapiens_hsa030400.97412376
59Influenza A_Homo sapiens_hsa051640.93585274
60VEGF signaling pathway_Homo sapiens_hsa043700.92373727
61Axon guidance_Homo sapiens_hsa043600.91430143
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.91174241
63Endometrial cancer_Homo sapiens_hsa052130.89910513
64Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.89119287
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88852747
66Toll-like receptor signaling pathway_Homo sapiens_hsa046200.86695909
67Cholinergic synapse_Homo sapiens_hsa047250.86228818
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.85566248
69Adherens junction_Homo sapiens_hsa045200.84664902
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.83632030
71Long-term potentiation_Homo sapiens_hsa047200.83432239
72One carbon pool by folate_Homo sapiens_hsa006700.82607554
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.81848588
74RNA transport_Homo sapiens_hsa030130.80816045
75GnRH signaling pathway_Homo sapiens_hsa049120.79733436
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79682312
77HIF-1 signaling pathway_Homo sapiens_hsa040660.79512620
78Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78883668
79TNF signaling pathway_Homo sapiens_hsa046680.78385419
80Epstein-Barr virus infection_Homo sapiens_hsa051690.78169268
81Prostate cancer_Homo sapiens_hsa052150.77413045
82Amoebiasis_Homo sapiens_hsa051460.76552707
83Type II diabetes mellitus_Homo sapiens_hsa049300.75591425
84FoxO signaling pathway_Homo sapiens_hsa040680.75466467
85Nicotine addiction_Homo sapiens_hsa050330.75206193
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.74860124
87Glycosaminoglycan degradation_Homo sapiens_hsa005310.74560379
88Thyroid hormone synthesis_Homo sapiens_hsa049180.73642848
89Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.72923375
90Insulin resistance_Homo sapiens_hsa049310.72619249
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72249681
92Prolactin signaling pathway_Homo sapiens_hsa049170.70827802
93Salmonella infection_Homo sapiens_hsa051320.70527465
94Pathways in cancer_Homo sapiens_hsa052000.69913622
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.69437162
96ECM-receptor interaction_Homo sapiens_hsa045120.69270545
97Bladder cancer_Homo sapiens_hsa052190.69053386
98MAPK signaling pathway_Homo sapiens_hsa040100.66422666
99Inositol phosphate metabolism_Homo sapiens_hsa005620.66026613
100Staphylococcus aureus infection_Homo sapiens_hsa051500.64971406
101AMPK signaling pathway_Homo sapiens_hsa041520.64166110
102Taste transduction_Homo sapiens_hsa047420.64093817
103Glucagon signaling pathway_Homo sapiens_hsa049220.63959914
104Endocytosis_Homo sapiens_hsa041440.63759688
105Glutamatergic synapse_Homo sapiens_hsa047240.62947862
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61316421
107Thyroid cancer_Homo sapiens_hsa052160.60849136
108Legionellosis_Homo sapiens_hsa051340.60481941
109Estrogen signaling pathway_Homo sapiens_hsa049150.59963240
110Rap1 signaling pathway_Homo sapiens_hsa040150.59446134
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.59043336
112Fanconi anemia pathway_Homo sapiens_hsa034600.58101658
113Malaria_Homo sapiens_hsa051440.57974386
114Dorso-ventral axis formation_Homo sapiens_hsa043200.57058536
115Other glycan degradation_Homo sapiens_hsa005110.56716370
116RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.56438045
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56107066
118Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55875548
119Long-term depression_Homo sapiens_hsa047300.55308284
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55122992
121Renal cell carcinoma_Homo sapiens_hsa052110.54979106
122N-Glycan biosynthesis_Homo sapiens_hsa005100.53492204
123Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52983267
124Insulin signaling pathway_Homo sapiens_hsa049100.52279624
125Homologous recombination_Homo sapiens_hsa034400.51956563
126Oxytocin signaling pathway_Homo sapiens_hsa049210.51243663
127Hippo signaling pathway_Homo sapiens_hsa043900.50451649
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.43601622
129Ras signaling pathway_Homo sapiens_hsa040140.43388281

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