CEP290

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with 13 putative coiled-coil domains, a region with homology to SMC chromosome segregation ATPases, six KID motifs, three tropomyosin homology domains and an ATP/GTP binding site motif A. The protein is localized to the centrosome and cilia and has sites for N-glycosylation, tyrosine sulfation, phosphorylation, N-myristoylation, and amidation. Mutations in this gene have been associated with Joubert syndrome and nephronophthisis and the presence of antibodies against this protein is associated with several forms of cancer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)8.85455700
2epithelial cilium movement (GO:0003351)6.49621986
3axonemal dynein complex assembly (GO:0070286)6.46130441
4cilium movement (GO:0003341)6.30324757
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.96238967
6fusion of sperm to egg plasma membrane (GO:0007342)5.64107128
7motile cilium assembly (GO:0044458)5.50662119
8acrosome assembly (GO:0001675)5.42380105
9regulation of rhodopsin mediated signaling pathway (GO:0022400)5.23944682
10sperm motility (GO:0030317)5.19421435
11retinal cone cell development (GO:0046549)5.16326866
12male meiosis (GO:0007140)5.09069740
13rhodopsin mediated signaling pathway (GO:0016056)5.06287092
14piRNA metabolic process (GO:0034587)5.03296789
15cell wall macromolecule metabolic process (GO:0044036)4.99718913
16cell wall macromolecule catabolic process (GO:0016998)4.99718913
17multicellular organism reproduction (GO:0032504)4.90366583
18sperm-egg recognition (GO:0035036)4.57796690
19photoreceptor cell maintenance (GO:0045494)4.52586726
20retinal rod cell development (GO:0046548)4.50704347
21* photoreceptor cell development (GO:0042461)4.50580316
22mitotic sister chromatid cohesion (GO:0007064)4.47941899
23intraciliary transport (GO:0042073)4.47941292
24plasma membrane fusion (GO:0045026)4.42627261
25axoneme assembly (GO:0035082)4.42032850
26* eye photoreceptor cell development (GO:0042462)4.41507331
27spermatid development (GO:0007286)4.31847023
28synaptonemal complex organization (GO:0070193)4.28812544
29acrosome reaction (GO:0007340)4.25128259
30synaptonemal complex assembly (GO:0007130)4.24761178
31binding of sperm to zona pellucida (GO:0007339)4.19628164
32ventricular system development (GO:0021591)4.16237200
33cell-cell recognition (GO:0009988)4.05140094
34detection of light stimulus involved in visual perception (GO:0050908)4.00089715
35detection of light stimulus involved in sensory perception (GO:0050962)4.00089715
36microtubule depolymerization (GO:0007019)3.94132345
37* cilium organization (GO:0044782)3.70831555
38regulation of cilium movement (GO:0003352)3.67929687
39reproduction (GO:0000003)3.67264287
40regulation of centriole replication (GO:0046599)3.64126247
41DNA methylation involved in gamete generation (GO:0043046)3.62802051
42nuclear pore complex assembly (GO:0051292)3.58675583
43* cilium assembly (GO:0042384)3.55954118
44protein localization to cilium (GO:0061512)3.50467244
45single fertilization (GO:0007338)3.42347212
46limb bud formation (GO:0060174)3.42264810
47male meiosis I (GO:0007141)3.40397921
48replicative senescence (GO:0090399)3.38404435
49chromosome organization involved in meiosis (GO:0070192)3.35840260
50nonmotile primary cilium assembly (GO:0035058)3.35382936
51centriole replication (GO:0007099)3.28418422
52retinal ganglion cell axon guidance (GO:0031290)3.25079967
53somite development (GO:0061053)3.23599002
54presynaptic membrane assembly (GO:0097105)3.22667966
55meiotic nuclear division (GO:0007126)3.22631064
56centriole assembly (GO:0098534)3.18412705
57lactate metabolic process (GO:0006089)3.17982038
58pyrimidine nucleobase catabolic process (GO:0006208)3.11793116
59sister chromatid cohesion (GO:0007062)3.10378786
60regulation of DNA endoreduplication (GO:0032875)3.10132230
61photoreceptor cell differentiation (GO:0046530)3.06838813
62eye photoreceptor cell differentiation (GO:0001754)3.06838813
63regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.06185954
64fertilization (GO:0009566)3.01758015
65axonal fasciculation (GO:0007413)3.00941015
66visual perception (GO:0007601)3.00699453
67* cellular component assembly involved in morphogenesis (GO:0010927)2.98449600
68sensory perception of light stimulus (GO:0050953)2.97980347
69presynaptic membrane organization (GO:0097090)2.97523306
70negative regulation of DNA-dependent DNA replication (GO:2000104)2.95194764
71neural tube formation (GO:0001841)2.93558767
72microtubule anchoring (GO:0034453)2.92905514
73nuclear pore organization (GO:0006999)2.92805834
74spermatogenesis (GO:0007283)2.91442765
75male gamete generation (GO:0048232)2.90902830
76sperm capacitation (GO:0048240)2.90412347
77microtubule-based movement (GO:0007018)2.90391821
78GMP metabolic process (GO:0046037)2.89900075
79chromatin remodeling at centromere (GO:0031055)2.88779688
80histone H3-K9 methylation (GO:0051567)2.88501140
81spermatid nucleus differentiation (GO:0007289)2.88439106
82* cilium morphogenesis (GO:0060271)2.87175299
83replication fork processing (GO:0031297)2.84408678
84cerebral cortex radially oriented cell migration (GO:0021799)2.83217846
85pore complex assembly (GO:0046931)2.79933157
86detection of visible light (GO:0009584)2.79818337
87positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.79349632
88positive regulation of mitotic sister chromatid separation (GO:1901970)2.79349632
89positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.79349632
90protein K11-linked deubiquitination (GO:0035871)2.79019701
91regulation of meiosis I (GO:0060631)2.78328392
92negative regulation of axon guidance (GO:1902668)2.77714223
93regulation of non-canonical Wnt signaling pathway (GO:2000050)2.76686983
94germ cell development (GO:0007281)2.74093723
95left/right axis specification (GO:0070986)2.73281855
96* retina development in camera-type eye (GO:0060041)2.73102756
97gamete generation (GO:0007276)2.72363750
98neuron recognition (GO:0008038)2.72065671
99detection of light stimulus (GO:0009583)2.72065282
100meiotic cell cycle (GO:0051321)2.71597844
101behavioral response to nicotine (GO:0035095)2.70847788
102microtubule polymerization or depolymerization (GO:0031109)2.70624288
103response to pheromone (GO:0019236)2.69017733
104limb development (GO:0060173)2.68486983
105appendage development (GO:0048736)2.68486983
106protein targeting to Golgi (GO:0000042)2.68438748
107cellular process involved in reproduction in multicellular organism (GO:0022412)2.68261441
108positive regulation of dendritic spine morphogenesis (GO:0061003)2.67768755
109neuronal stem cell maintenance (GO:0097150)2.66808662
110CENP-A containing nucleosome assembly (GO:0034080)2.65539830
111resolution of meiotic recombination intermediates (GO:0000712)2.65284287
112negative regulation of inclusion body assembly (GO:0090084)2.64634575
113microtubule organizing center organization (GO:0031023)2.64099120
114phototransduction (GO:0007602)2.62146274
115phototransduction, visible light (GO:0007603)2.60896212
116retrograde transport, vesicle recycling within Golgi (GO:0000301)2.59712983
117regulation of microtubule-based movement (GO:0060632)2.59052179
118smoothened signaling pathway (GO:0007224)2.57900083
119calcium ion-dependent exocytosis (GO:0017156)2.57411020
120meiosis I (GO:0007127)2.56619929
121cellular response to light stimulus (GO:0071482)2.54859468
122kinetochore organization (GO:0051383)2.54437222
123centrosome organization (GO:0051297)2.53363864
124regulation of centrosome duplication (GO:0010824)2.52989307
125monoubiquitinated protein deubiquitination (GO:0035520)2.52842163
126establishment of protein localization to Golgi (GO:0072600)2.52396888
127regulation of pigment cell differentiation (GO:0050932)2.51765545
128positive regulation of developmental pigmentation (GO:0048087)2.51097878
129regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.50530088
130DNA double-strand break processing (GO:0000729)2.50195906
131central nervous system projection neuron axonogenesis (GO:0021952)2.48852985
132postsynaptic membrane organization (GO:0001941)2.46762175
133negative regulation of astrocyte differentiation (GO:0048712)2.43873277
134histone exchange (GO:0043486)2.40776010
135olfactory bulb development (GO:0021772)2.40382914
136auditory behavior (GO:0031223)2.40246741
137nucleobase catabolic process (GO:0046113)2.38230365
138negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.38043441
139negative regulation of translation, ncRNA-mediated (GO:0040033)2.38043441
140regulation of translation, ncRNA-mediated (GO:0045974)2.38043441
141protein prenylation (GO:0018342)2.37234794
142prenylation (GO:0097354)2.37234794
143histone H2A acetylation (GO:0043968)2.36536222
144neuron cell-cell adhesion (GO:0007158)2.36510970
145* hindbrain development (GO:0030902)2.35014276
146cell proliferation in forebrain (GO:0021846)2.33318436
147maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.32352527
148kinetochore assembly (GO:0051382)2.31715203
149negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.29890893
150spinal cord motor neuron differentiation (GO:0021522)2.29242443
151mechanosensory behavior (GO:0007638)2.29113580
152intra-S DNA damage checkpoint (GO:0031573)2.28484485
153forebrain neuron differentiation (GO:0021879)2.27989812
154behavioral response to ethanol (GO:0048149)2.27232311
155regulation of axon guidance (GO:1902667)2.25298757
156recombinational repair (GO:0000725)2.23721954
157sympathetic nervous system development (GO:0048485)2.23136902
158reciprocal meiotic recombination (GO:0007131)2.22677777
159reciprocal DNA recombination (GO:0035825)2.22677777
160neuron fate determination (GO:0048664)2.21697064
161double-strand break repair via homologous recombination (GO:0000724)2.21616634
162central nervous system neuron axonogenesis (GO:0021955)2.21227252
163negative regulation of DNA recombination (GO:0045910)2.20711164
164head development (GO:0060322)2.18906529
165determination of left/right symmetry (GO:0007368)2.18292998
166DNA replication-independent nucleosome assembly (GO:0006336)2.18208086
167DNA replication-independent nucleosome organization (GO:0034724)2.18208086

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.07890412
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.51565911
3EZH2_22144423_ChIP-Seq_EOC_Human2.95793137
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.93748619
5GBX2_23144817_ChIP-Seq_PC3_Human2.72709065
6* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.54960515
7FUS_26573619_Chip-Seq_HEK293_Human2.47180109
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.45574333
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.44177250
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.44169117
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.40070732
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.35146451
13E2F7_22180533_ChIP-Seq_HELA_Human2.33795654
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.30723116
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.26732577
16SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.15613265
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.13303377
18PCGF2_27294783_Chip-Seq_ESCs_Mouse2.12048616
19TAF15_26573619_Chip-Seq_HEK293_Human2.06203249
20TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.91381071
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.90662567
22SMAD4_21799915_ChIP-Seq_A2780_Human1.84296751
23PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.83362521
24NANOG_18555785_Chip-Seq_ESCs_Mouse1.78181017
25VDR_22108803_ChIP-Seq_LS180_Human1.77546944
26EWS_26573619_Chip-Seq_HEK293_Human1.72536191
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.72185500
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.71108456
29KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.69778205
30MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.69751953
31SUZ12_27294783_Chip-Seq_NPCs_Mouse1.69284000
32RNF2_27304074_Chip-Seq_NSC_Mouse1.67256459
33P300_19829295_ChIP-Seq_ESCs_Human1.62892171
34EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.61362983
35NFE2_27457419_Chip-Seq_LIVER_Mouse1.60924442
36TP63_19390658_ChIP-ChIP_HaCaT_Human1.60871599
37CBX2_27304074_Chip-Seq_ESCs_Mouse1.59698239
38E2F1_18555785_Chip-Seq_ESCs_Mouse1.54210470
39TCF4_23295773_ChIP-Seq_U87_Human1.54165798
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.52323973
41STAT3_23295773_ChIP-Seq_U87_Human1.51724908
42POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.51565001
43TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51565001
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50690111
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.48214329
46P53_22387025_ChIP-Seq_ESCs_Mouse1.47174581
47ER_23166858_ChIP-Seq_MCF-7_Human1.46495002
48PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46467593
49IGF1R_20145208_ChIP-Seq_DFB_Human1.45643610
50ELK1_19687146_ChIP-ChIP_HELA_Human1.43749594
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43130955
52CMYC_18555785_Chip-Seq_ESCs_Mouse1.42947942
53SUZ12_18555785_Chip-Seq_ESCs_Mouse1.41966548
54ZNF274_21170338_ChIP-Seq_K562_Hela1.40533114
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39888619
56POU5F1_16153702_ChIP-ChIP_HESCs_Human1.39862675
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39704030
58CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.39594558
59HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.39502601
60RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.38947286
61EZH2_27294783_Chip-Seq_NPCs_Mouse1.38928406
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.38373245
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38287700
64P300_18555785_Chip-Seq_ESCs_Mouse1.37735549
65GATA1_26923725_Chip-Seq_HPCs_Mouse1.37461061
66TAL1_26923725_Chip-Seq_HPCs_Mouse1.37156752
67TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.36782913
68BCAT_22108803_ChIP-Seq_LS180_Human1.35696157
69EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.35125530
70CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.33101628
71PIAS1_25552417_ChIP-Seq_VCAP_Human1.32448596
72SOX9_26525672_Chip-Seq_HEART_Mouse1.31313607
73STAT3_18555785_Chip-Seq_ESCs_Mouse1.31172657
74OCT4_18555785_Chip-Seq_ESCs_Mouse1.30787088
75BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30584670
76CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28867249
77SOX2_18555785_Chip-Seq_ESCs_Mouse1.26423629
78EZH2_27304074_Chip-Seq_ESCs_Mouse1.26339644
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26221897
80TP53_16413492_ChIP-PET_HCT116_Human1.26183670
81E2F4_17652178_ChIP-ChIP_JURKAT_Human1.25133149
82SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24708891
83KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.23941239
84AR_21572438_ChIP-Seq_LNCaP_Human1.22268710
85RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20602442
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20166055
87CBP_20019798_ChIP-Seq_JUKART_Human1.20166055
88* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.19631314
89OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17590743
90KDM2B_26808549_Chip-Seq_REH_Human1.17559772
91TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17307606
92STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.17102655
93KLF4_18555785_Chip-Seq_ESCs_Mouse1.16689883
94FOXM1_23109430_ChIP-Seq_U2OS_Human1.16422836
95JARID2_20064375_ChIP-Seq_MESCs_Mouse1.15766985
96TCF4_22108803_ChIP-Seq_LS180_Human1.15398761
97ZFX_18555785_Chip-Seq_ESCs_Mouse1.14677804
98MYC_18940864_ChIP-ChIP_HL60_Human1.14109345
99* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13988621
100NMYC_18555785_Chip-Seq_ESCs_Mouse1.13782919
101CTCF_18555785_Chip-Seq_ESCs_Mouse1.13493473
102HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.12602888
103IRF1_19129219_ChIP-ChIP_H3396_Human1.12513860
104ESRRB_18555785_Chip-Seq_ESCs_Mouse1.12366691
105KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11998651
106SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11770007
107CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.10521317
108* FLI1_21867929_ChIP-Seq_TH2_Mouse1.10291558
109FOXM1_26456572_ChIP-Seq_MCF-7_Human1.10290590
110RUNX1_27457419_Chip-Seq_LIVER_Mouse1.09411647
111NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09207309
112RUNX2_22187159_ChIP-Seq_PCA_Human1.07896461
113PU1_27457419_Chip-Seq_LIVER_Mouse1.07586621
114REST_21632747_ChIP-Seq_MESCs_Mouse1.07113877
115* EST1_17652178_ChIP-ChIP_JURKAT_Human1.06854820
116LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06667312
117JUN_21703547_ChIP-Seq_K562_Human1.05738453
118GABP_17652178_ChIP-ChIP_JURKAT_Human1.05675760
119SOX2_21211035_ChIP-Seq_LN229_Gbm1.04475867
120TBL1_22424771_ChIP-Seq_293T_Human1.04085361
121* CRX_20693478_ChIP-Seq_RETINA_Mouse1.04080531
122EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01695754
123RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01405143
124MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01210267
125PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01117544
126AR_25329375_ChIP-Seq_VCAP_Human1.01058418
127CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00620376
128E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.99586509
129EED_16625203_ChIP-ChIP_MESCs_Mouse0.99547255
130SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.95765043

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization4.73489083
2* MP0005551_abnormal_eye_electrophysiolog4.62716911
3MP0008877_abnormal_DNA_methylation3.78827321
4MP0006072_abnormal_retinal_apoptosis3.45693954
5MP0005253_abnormal_eye_physiology3.22878875
6MP0000569_abnormal_digit_pigmentation2.74249728
7MP0003698_abnormal_male_reproductive2.60722597
8MP0003787_abnormal_imprinting2.59514726
9MP0001929_abnormal_gametogenesis2.42203876
10MP0002653_abnormal_ependyma_morphology2.39707200
11MP0001188_hyperpigmentation2.30665894
12MP0008058_abnormal_DNA_repair2.17084420
13MP0003011_delayed_dark_adaptation2.08344186
14MP0008057_abnormal_DNA_replication2.01497941
15MP0002210_abnormal_sex_determination1.93569194
16MP0001984_abnormal_olfaction1.92136913
17* MP0005195_abnormal_posterior_eye1.91188343
18MP0003121_genomic_imprinting1.90736542
19MP0010094_abnormal_chromosome_stability1.84951261
20MP0002234_abnormal_pharynx_morphology1.79273504
21MP0005391_vision/eye_phenotype1.72665313
22MP0006292_abnormal_olfactory_placode1.71308595
23MP0001986_abnormal_taste_sensitivity1.70723109
24* MP0001324_abnormal_eye_pigmentation1.70608783
25MP0004133_heterotaxia1.62629928
26MP0003950_abnormal_plasma_membrane1.61451983
27MP0003890_abnormal_embryonic-extraembry1.59178051
28MP0001145_abnormal_male_reproductive1.56064247
29MP0000653_abnormal_sex_gland1.44513064
30MP0002638_abnormal_pupillary_reflex1.44357930
31MP0002751_abnormal_autonomic_nervous1.42814316
32MP0002928_abnormal_bile_duct1.41852411
33MP0009046_muscle_twitch1.39781634
34MP0002090_abnormal_vision1.38062312
35MP0002161_abnormal_fertility/fecundity1.37872916
36MP0002229_neurodegeneration1.36148593
37MP0000383_abnormal_hair_follicle1.35426797
38MP0000955_abnormal_spinal_cord1.35398125
39MP0002184_abnormal_innervation1.35302319
40MP0001286_abnormal_eye_development1.34859210
41MP0001529_abnormal_vocalization1.34471419
42MP0005171_absent_coat_pigmentation1.32615155
43MP0006276_abnormal_autonomic_nervous1.32281913
44MP0002160_abnormal_reproductive_system1.30785682
45MP0003111_abnormal_nucleus_morphology1.30330673
46MP0002735_abnormal_chemical_nociception1.26645756
47MP0004885_abnormal_endolymph1.25836091
48MP0003123_paternal_imprinting1.25531808
49MP0008004_abnormal_stomach_pH1.23781130
50MP0002736_abnormal_nociception_after1.23033468
51MP0003122_maternal_imprinting1.22475818
52MP0009780_abnormal_chondrocyte_physiolo1.22335289
53MP0004859_abnormal_synaptic_plasticity1.21663140
54* MP0002752_abnormal_somatic_nervous1.19671352
55MP0000049_abnormal_middle_ear1.18838518
56MP0005187_abnormal_penis_morphology1.18522112
57MP0003693_abnormal_embryo_hatching1.17969027
58MP0001502_abnormal_circadian_rhythm1.17283203
59MP0002697_abnormal_eye_size1.17266794
60MP0005623_abnormal_meninges_morphology1.16638335
61MP0000015_abnormal_ear_pigmentation1.16405724
62MP0000631_abnormal_neuroendocrine_gland1.16141936
63MP0001485_abnormal_pinna_reflex1.14500304
64MP0002938_white_spotting1.13572664
65MP0003119_abnormal_digestive_system1.12291498
66MP0005499_abnormal_olfactory_system1.12085349
67MP0005394_taste/olfaction_phenotype1.12085349
68MP0002282_abnormal_trachea_morphology1.11502366
69MP0002063_abnormal_learning/memory/cond1.09568756
70MP0008995_early_reproductive_senescence1.06608504
71MP0004142_abnormal_muscle_tone1.05447543
72MP0003942_abnormal_urinary_system1.04185829
73MP0003938_abnormal_ear_development1.03661315
74MP0003077_abnormal_cell_cycle1.03590474
75MP0005409_darkened_coat_color1.03185596
76MP0002837_dystrophic_cardiac_calcinosis1.02279128
77MP0010030_abnormal_orbit_morphology1.01015847
78MP0008789_abnormal_olfactory_epithelium1.01014098
79MP0003937_abnormal_limbs/digits/tail_de1.00364028
80MP0005646_abnormal_pituitary_gland0.97467043
81MP0003385_abnormal_body_wall0.97109283
82MP0003045_fibrosis0.96992275
83MP0008007_abnormal_cellular_replicative0.96270881
84MP0003567_abnormal_fetal_cardiomyocyte0.95220598
85MP0002084_abnormal_developmental_patter0.95205300
86* MP0002882_abnormal_neuron_morphology0.94707587
87MP0002163_abnormal_gland_morphology0.93788294
88MP0004134_abnormal_chest_morphology0.93434142
89MP0000647_abnormal_sebaceous_gland0.93086109
90MP0004270_analgesia0.92551696
91MP0003136_yellow_coat_color0.92050405
92MP0001968_abnormal_touch/_nociception0.90866554
93MP0000026_abnormal_inner_ear0.90738686
94MP0001486_abnormal_startle_reflex0.90070109
95MP0005248_abnormal_Harderian_gland0.87888935
96MP0000778_abnormal_nervous_system0.86534352
97MP0004924_abnormal_behavior0.84752909
98MP0005386_behavior/neurological_phenoty0.84752909
99MP0004233_abnormal_muscle_weight0.84706554
100MP0003880_abnormal_central_pattern0.84566531
101MP0003283_abnormal_digestive_organ0.84418318
102MP0009703_decreased_birth_body0.82564308
103MP0002822_catalepsy0.82467055
104MP0003755_abnormal_palate_morphology0.82466201
105MP0000534_abnormal_ureter_morphology0.82449553
106MP0004811_abnormal_neuron_physiology0.82348904
107MP0005379_endocrine/exocrine_gland_phen0.82333942
108MP0002067_abnormal_sensory_capabilities0.81416719
109MP0002095_abnormal_skin_pigmentation0.81093184
110MP0002109_abnormal_limb_morphology0.80791745
111MP0000566_synostosis0.80235948
112MP0005389_reproductive_system_phenotype0.79977912
113MP0001293_anophthalmia0.79845954
114MP0008932_abnormal_embryonic_tissue0.79734044
115MP0004742_abnormal_vestibular_system0.79509526
116MP0009697_abnormal_copulation0.78903961
117MP0000427_abnormal_hair_cycle0.78181310
118MP0003935_abnormal_craniofacial_develop0.77135174
119MP0002272_abnormal_nervous_system0.77121559
120MP0003861_abnormal_nervous_system0.76192134
121MP0001177_atelectasis0.75399080
122MP0002557_abnormal_social/conspecific_i0.74659295
123MP0005423_abnormal_somatic_nervous0.74435809
124MP0009745_abnormal_behavioral_response0.74239749
125MP0000432_abnormal_head_morphology0.74200171
126MP0002233_abnormal_nose_morphology0.73361231
127MP0002734_abnormal_mechanical_nocicepti0.73276733
128MP0003183_abnormal_peptide_metabolism0.73051255
129MP0003786_premature_aging0.72697536
130MP0001963_abnormal_hearing_physiology0.72273508
131MP0003635_abnormal_synaptic_transmissio0.72073724
132MP0003941_abnormal_skin_development0.71794451
133MP0002152_abnormal_brain_morphology0.71697828
134MP0001299_abnormal_eye_distance/0.71001212
135MP0002572_abnormal_emotion/affect_behav0.70553809
136MP0009250_abnormal_appendicular_skeleto0.69679300
137MP0002064_seizures0.69574911
138MP0002102_abnormal_ear_morphology0.69258563
139MP0002116_abnormal_craniofacial_bone0.68343391

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.62777334
2Absent/shortened dynein arms (HP:0200106)6.50498284
3Dynein arm defect of respiratory motile cilia (HP:0012255)6.50498284
4Congenital stationary night blindness (HP:0007642)6.26600756
5Abnormal respiratory motile cilium physiology (HP:0012261)5.92474628
6Abnormal ciliary motility (HP:0012262)5.40569517
7Abnormal respiratory epithelium morphology (HP:0012253)5.14173794
8Abnormal respiratory motile cilium morphology (HP:0005938)5.14173794
9Rhinitis (HP:0012384)4.84708606
10Bony spicule pigmentary retinopathy (HP:0007737)4.74863217
11Absent rod-and cone-mediated responses on ERG (HP:0007688)4.25293776
12Abnormal rod and cone electroretinograms (HP:0008323)4.24947780
13Dyschromatopsia (HP:0007641)4.14278953
14Central scotoma (HP:0000603)3.97682697
15Decreased central vision (HP:0007663)3.97256480
16Chronic bronchitis (HP:0004469)3.96224737
17Abnormality of macular pigmentation (HP:0008002)3.95795657
18Pendular nystagmus (HP:0012043)3.77066164
19Attenuation of retinal blood vessels (HP:0007843)3.74468441
20Severe visual impairment (HP:0001141)3.57188738
21Chorioretinal atrophy (HP:0000533)3.48024169
22* Pancreatic fibrosis (HP:0100732)3.32778092
23Scotoma (HP:0000575)3.32506320
24* True hermaphroditism (HP:0010459)3.27130344
25Tubulointerstitial nephritis (HP:0001970)3.17554698
26* Nephronophthisis (HP:0000090)3.15786427
27Abolished electroretinogram (ERG) (HP:0000550)3.04886272
28Cone-rod dystrophy (HP:0000548)2.99983010
29* Medial flaring of the eyebrow (HP:0010747)2.96516465
30Hyperventilation (HP:0002883)2.80889212
31Type II diabetes mellitus (HP:0005978)2.74198559
32* Abnormality of midbrain morphology (HP:0002418)2.71835839
33* Molar tooth sign on MRI (HP:0002419)2.71835839
34Intestinal atresia (HP:0011100)2.69190477
35Photophobia (HP:0000613)2.66871283
36Bronchiectasis (HP:0002110)2.65674423
37* Cystic liver disease (HP:0006706)2.64506662
38* Aplasia/Hypoplasia of the tongue (HP:0010295)2.63961926
39* Congenital primary aphakia (HP:0007707)2.56441139
40Volvulus (HP:0002580)2.55902927
41* Gait imbalance (HP:0002141)2.54751207
42Oligodactyly (hands) (HP:0001180)2.54083369
43Aplasia/Hypoplasia of the uvula (HP:0010293)2.51721004
44* Abnormality of the renal medulla (HP:0100957)2.51348782
45Macular degeneration (HP:0000608)2.49976749
46Drooling (HP:0002307)2.48871030
47Chronic hepatic failure (HP:0100626)2.47803732
48Pigmentary retinal degeneration (HP:0001146)2.46133501
49Vitreoretinal degeneration (HP:0000655)2.42417068
50Aplasia/Hypoplasia of the tibia (HP:0005772)2.41247222
51* Postaxial foot polydactyly (HP:0001830)2.38468597
52Fibular hypoplasia (HP:0003038)2.36366568
53Occipital encephalocele (HP:0002085)2.32102467
54Increased corneal curvature (HP:0100692)2.31552624
55Keratoconus (HP:0000563)2.31552624
56* Nephrogenic diabetes insipidus (HP:0009806)2.31526660
57Broad-based gait (HP:0002136)2.30966119
58Neoplasm of the adrenal cortex (HP:0100641)2.29673387
59Infertility (HP:0000789)2.29302782
60Abnormality of the labia minora (HP:0012880)2.29015417
61* Pancreatic cysts (HP:0001737)2.20898475
62Anophthalmia (HP:0000528)2.20609252
63Optic nerve hypoplasia (HP:0000609)2.19871701
64Excessive salivation (HP:0003781)2.18165584
65Colon cancer (HP:0003003)2.17874371
66* Retinitis pigmentosa (HP:0000510)2.17141374
67* Poor coordination (HP:0002370)2.16364604
68Constricted visual fields (HP:0001133)2.15498983
69Gastrointestinal atresia (HP:0002589)2.15398868
70Septo-optic dysplasia (HP:0100842)2.12412109
71Papillary thyroid carcinoma (HP:0002895)2.11015640
72* Genital tract atresia (HP:0001827)2.10707367
73Bifid tongue (HP:0010297)2.09356140
74Focal motor seizures (HP:0011153)2.07004083
75Abnormality of the ileum (HP:0001549)2.05802989
76Meckel diverticulum (HP:0002245)2.03569524
77Facial cleft (HP:0002006)2.01156680
78Supernumerary spleens (HP:0009799)1.97617594
79* Vaginal atresia (HP:0000148)1.97011656
80Choroideremia (HP:0001139)1.95332841
81* Preaxial hand polydactyly (HP:0001177)1.94423853
82* Abnormality of the renal cortex (HP:0011035)1.94296938
83Median cleft lip (HP:0000161)1.92685121
84Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.90700792
85Congenital sensorineural hearing impairment (HP:0008527)1.90148192
86Hip dysplasia (HP:0001385)1.88471045
87Posterior subcapsular cataract (HP:0007787)1.87434862
88* Anencephaly (HP:0002323)1.86886201
89* Narrow forehead (HP:0000341)1.86795350
90* Congenital hepatic fibrosis (HP:0002612)1.86795183
91Recurrent sinusitis (HP:0011108)1.86436506
92* Specific learning disability (HP:0001328)1.86019728
93* Postaxial hand polydactyly (HP:0001162)1.86009813
94Abnormality of the ischium (HP:0003174)1.85948449
95Hepatoblastoma (HP:0002884)1.84856264
96Febrile seizures (HP:0002373)1.83595784
97Triphalangeal thumb (HP:0001199)1.83108141
98Absent speech (HP:0001344)1.82999680
99Esophageal atresia (HP:0002032)1.80999283
100Short tibia (HP:0005736)1.80945118
101Rib fusion (HP:0000902)1.80863285
102* Short foot (HP:0001773)1.79984834
103Renal hypoplasia (HP:0000089)1.79425355
104Atonic seizures (HP:0010819)1.75376729
105Nephroblastoma (Wilms tumor) (HP:0002667)1.75201036
106Embryonal renal neoplasm (HP:0011794)1.74940448
107Bronchitis (HP:0012387)1.73778150
108Small hand (HP:0200055)1.71448800
109Chromsome breakage (HP:0040012)1.71430649
110Progressive cerebellar ataxia (HP:0002073)1.70927341
111* Micropenis (HP:0000054)1.70466438
112Lissencephaly (HP:0001339)1.70412170
113Focal seizures (HP:0007359)1.70236800
114Abnormal spermatogenesis (HP:0008669)1.68235990
115Tubulointerstitial abnormality (HP:0001969)1.67626158
116Type II lissencephaly (HP:0007260)1.66970531
117* Aganglionic megacolon (HP:0002251)1.66576838
118Cerebellar dysplasia (HP:0007033)1.65657865
119Cutaneous finger syndactyly (HP:0010554)1.64567774
120Gaze-evoked nystagmus (HP:0000640)1.64398818
121Abnormal hair whorl (HP:0010721)1.64297321
122* Sloping forehead (HP:0000340)1.64227665
123Aqueductal stenosis (HP:0002410)1.64146748
124Oligodactyly (HP:0012165)1.64028159
125Abnormality of the duodenum (HP:0002246)1.63099958
126Tubular atrophy (HP:0000092)1.62750208
127Short ribs (HP:0000773)1.62179301
128* Aplasia/Hypoplasia of the lens (HP:0008063)1.61544471
129* Astigmatism (HP:0000483)1.61481461
130* Sclerocornea (HP:0000647)1.61410697
131Protruding tongue (HP:0010808)1.61372152
132Truncal obesity (HP:0001956)1.61254842
133Broad alveolar ridges (HP:0000187)1.60779467
134Abdominal situs inversus (HP:0003363)1.60296734
135Abnormality of abdominal situs (HP:0011620)1.60296734
136Small intestinal stenosis (HP:0012848)1.59974550
137Duodenal stenosis (HP:0100867)1.59974550
138* Prominent nasal bridge (HP:0000426)1.59911897
139Ectopic kidney (HP:0000086)1.59805925
140Growth hormone deficiency (HP:0000824)1.58590631
141* Multicystic kidney dysplasia (HP:0000003)1.58416648
142* Dandy-Walker malformation (HP:0001305)1.57798627
143Aplasia/Hypoplasia of the sternum (HP:0006714)1.57274342
144Epileptic encephalopathy (HP:0200134)1.56629080
145Stomach cancer (HP:0012126)1.55959702
146* Male pseudohermaphroditism (HP:0000037)1.55037389
147Chromosomal breakage induced by crosslinking agents (HP:0003221)1.53769290
148Subcapsular cataract (HP:0000523)1.53382562
149Absent eyebrow (HP:0002223)1.52791056
150Microglossia (HP:0000171)1.52351761
151Aplasia/Hypoplasia of the fibula (HP:0006492)1.52142093
152* Oculomotor apraxia (HP:0000657)1.51321561
153Abnormality of chromosome stability (HP:0003220)1.49932714
154Bell-shaped thorax (HP:0001591)1.48992916
155Breast carcinoma (HP:0003002)1.47909401

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK4.15939186
2PDK33.54549330
3PDK43.54549330
4ZAK3.30582919
5NEK13.00929926
6CDC72.58025937
7MAP4K22.46596982
8PDK22.35282324
9FRK2.31591028
10TTK2.22543518
11PLK32.15170525
12AKT32.04318757
13GRK11.93559495
14BRD41.80022667
15PRKD31.74681174
16SRPK11.68177158
17PLK21.67792673
18NUAK11.63660352
19ACVR1B1.61823958
20CASK1.60607429
21CHEK21.53471494
22LATS11.52724158
23CAMK1G1.52219246
24NTRK21.48509322
25CDK121.48464498
26STK38L1.48412595
27CDK31.46681401
28PLK41.43004849
29TRIM281.38549596
30NEK21.38257316
31VRK11.35573880
32MAPK151.33875364
33MAP3K41.33846747
34WNK11.32812734
35ERBB31.32338360
36ATR1.29820722
37WEE11.27611025
38BRSK21.21914057
39NEK61.18672233
40ATM1.17221048
41MAP2K71.17150779
42SGK21.14844779
43PBK1.12969196
44BMPR1B1.11355148
45STK31.07641881
46EPHB21.06146496
47PLK11.05955318
48STK391.04051016
49FGFR21.02848905
50WNK41.02649264
51MKNK21.02618550
52PAK31.02268144
53INSRR1.01915062
54CHEK11.00546912
55DYRK20.98696610
56LMTK20.95389409
57CCNB10.94249467
58PINK10.92113789
59MAPK130.92096758
60TGFBR10.87613356
61BMPR20.84233175
62DYRK30.81663478
63NTRK30.80309870
64PASK0.79631034
65UHMK10.77387227
66MKNK10.76819098
67SGK30.75404591
68SIK30.74548148
69PRPF4B0.73871162
70SGK4940.73616798
71SGK2230.73616798
72CAMK1D0.70256173
73WNK30.67257040
74OXSR10.67238423
75EIF2AK30.66996969
76PTK2B0.66543240
77CSNK1G20.66272547
78CDK10.65940239
79STK380.64679120
80TRPM70.62198923
81PRKCH0.60524285
82PRKDC0.60414778
83CDK80.59213941
84CDK190.59176010
85KSR10.58335010
86CSNK1G10.55551664
87PRKACB0.55456845
88GSK3B0.54399647
89RPS6KB10.54273731
90FGFR10.53613196
91IRAK20.52735534
92CDK90.51725517
93CSNK1D0.51402912
94ADRBK20.51290760
95MAPK140.50518991
96RPS6KA50.50287944
97SGK10.50245764
98CDK20.49460363
99TSSK60.49256743
100BRAF0.47868485
101EPHA40.47819262
102SIK20.47388407
103ADRBK10.46895879
104YES10.46365799
105TAF10.46280884
106PKN10.45837892
107DYRK1A0.45734683
108NME10.45294734
109TAOK30.44614561
110CAMK2A0.44086497
111MAPK100.43397883
112EIF2AK20.43007947
113MAPKAPK50.42985340
114CSNK1E0.42832343
115PAK60.41972781
116PIK3CA0.41743105
117PRKG10.40193545
118MELK0.40133808
119AURKB0.39323876
120BCR0.39262118
121CSNK1A1L0.39182101
122MAP2K40.38782760
123CDK50.37019772
124NLK0.36874684
125PRKCG0.36193955
126TNIK0.35656782
127IRAK10.35624500
128ERBB20.35565271
129RIPK10.35431842
130MINK10.34949849
131PRKCE0.34619275
132MARK10.34610191
133CSNK1A10.34495456

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047447.14265482
2Fanconi anemia pathway_Homo sapiens_hsa034602.53532576
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.28713221
4Basal transcription factors_Homo sapiens_hsa030222.17291337
5Nicotine addiction_Homo sapiens_hsa050332.12227145
6Propanoate metabolism_Homo sapiens_hsa006401.73249083
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.72394300
8mRNA surveillance pathway_Homo sapiens_hsa030151.71380127
9Olfactory transduction_Homo sapiens_hsa047401.69671466
10Cell cycle_Homo sapiens_hsa041101.67850887
11Steroid biosynthesis_Homo sapiens_hsa001001.66627425
12Homologous recombination_Homo sapiens_hsa034401.59085415
13Synaptic vesicle cycle_Homo sapiens_hsa047211.58450240
14Non-homologous end-joining_Homo sapiens_hsa034501.56239119
15Vitamin B6 metabolism_Homo sapiens_hsa007501.50972486
16Circadian entrainment_Homo sapiens_hsa047131.50213682
17Insulin secretion_Homo sapiens_hsa049111.48485620
18Amphetamine addiction_Homo sapiens_hsa050311.46574915
19Butanoate metabolism_Homo sapiens_hsa006501.43102035
20Oocyte meiosis_Homo sapiens_hsa041141.42963826
21Morphine addiction_Homo sapiens_hsa050321.42197390
22Taste transduction_Homo sapiens_hsa047421.42162510
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.39132170
24Mismatch repair_Homo sapiens_hsa034301.38429838
25RNA polymerase_Homo sapiens_hsa030201.32775442
26Ribosome_Homo sapiens_hsa030101.30147171
27Axon guidance_Homo sapiens_hsa043601.29412666
28Serotonergic synapse_Homo sapiens_hsa047261.28937837
29RNA degradation_Homo sapiens_hsa030181.28862287
30Glutamatergic synapse_Homo sapiens_hsa047241.27960135
31GABAergic synapse_Homo sapiens_hsa047271.27146768
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.24054304
33Oxidative phosphorylation_Homo sapiens_hsa001901.22023217
34Nucleotide excision repair_Homo sapiens_hsa034201.21937490
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.21360171
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.19225448
37RNA transport_Homo sapiens_hsa030131.18774413
38Circadian rhythm_Homo sapiens_hsa047101.17973195
39Nitrogen metabolism_Homo sapiens_hsa009101.17823682
40Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.14005646
41Long-term potentiation_Homo sapiens_hsa047201.13530173
42One carbon pool by folate_Homo sapiens_hsa006701.12589534
43Selenocompound metabolism_Homo sapiens_hsa004501.11880141
44Dopaminergic synapse_Homo sapiens_hsa047281.11426399
45Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.11067601
46Renin secretion_Homo sapiens_hsa049241.09003334
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.06209625
48Parkinsons disease_Homo sapiens_hsa050121.00678834
49Dorso-ventral axis formation_Homo sapiens_hsa043201.00159624
50Purine metabolism_Homo sapiens_hsa002300.98702735
51Alcoholism_Homo sapiens_hsa050340.97474552
52cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95983034
53Wnt signaling pathway_Homo sapiens_hsa043100.95191871
54Hedgehog signaling pathway_Homo sapiens_hsa043400.93007577
55Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.92831222
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92461942
57Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.88863581
58Cholinergic synapse_Homo sapiens_hsa047250.88167575
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87396051
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.84244107
61Collecting duct acid secretion_Homo sapiens_hsa049660.80982257
62Spliceosome_Homo sapiens_hsa030400.80535875
63Regulation of autophagy_Homo sapiens_hsa041400.79594896
64Glucagon signaling pathway_Homo sapiens_hsa049220.79025979
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78961210
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77084749
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76166294
68Calcium signaling pathway_Homo sapiens_hsa040200.75970107
69DNA replication_Homo sapiens_hsa030300.74292675
70Long-term depression_Homo sapiens_hsa047300.73878379
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73568885
72p53 signaling pathway_Homo sapiens_hsa041150.72073752
73cAMP signaling pathway_Homo sapiens_hsa040240.71627293
74Systemic lupus erythematosus_Homo sapiens_hsa053220.71458078
75Huntingtons disease_Homo sapiens_hsa050160.70763748
76Salivary secretion_Homo sapiens_hsa049700.70231809
77Oxytocin signaling pathway_Homo sapiens_hsa049210.69958128
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.69792786
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.69774802
80Alzheimers disease_Homo sapiens_hsa050100.67770230
81Inositol phosphate metabolism_Homo sapiens_hsa005620.67434965
82Vibrio cholerae infection_Homo sapiens_hsa051100.66789561
83Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.66594962
84Ether lipid metabolism_Homo sapiens_hsa005650.64403111
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63931601
86Chemical carcinogenesis_Homo sapiens_hsa052040.62630337
87Basal cell carcinoma_Homo sapiens_hsa052170.62435583
88Type II diabetes mellitus_Homo sapiens_hsa049300.62132303
89Cocaine addiction_Homo sapiens_hsa050300.62054557
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.61842972
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60589563
92Linoleic acid metabolism_Homo sapiens_hsa005910.59186836
93Protein export_Homo sapiens_hsa030600.58749038
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58504581
95Prostate cancer_Homo sapiens_hsa052150.57884530
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57827091
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54336731
98Hippo signaling pathway_Homo sapiens_hsa043900.54336006
99Peroxisome_Homo sapiens_hsa041460.53321332
100Mineral absorption_Homo sapiens_hsa049780.52595079
101MAPK signaling pathway_Homo sapiens_hsa040100.52164316
102Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50635858
103Thyroid hormone synthesis_Homo sapiens_hsa049180.50215053
104Pyrimidine metabolism_Homo sapiens_hsa002400.50191643
105Melanoma_Homo sapiens_hsa052180.49857693
106Lysine degradation_Homo sapiens_hsa003100.49722675
107Tight junction_Homo sapiens_hsa045300.48681055
108Primary bile acid biosynthesis_Homo sapiens_hsa001200.48335081
109Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47387637
110Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.47362667
111Viral carcinogenesis_Homo sapiens_hsa052030.46881331
112Estrogen signaling pathway_Homo sapiens_hsa049150.45781908
113Gastric acid secretion_Homo sapiens_hsa049710.45288845
114Base excision repair_Homo sapiens_hsa034100.45073491
115Retinol metabolism_Homo sapiens_hsa008300.44464244
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44025665
117ErbB signaling pathway_Homo sapiens_hsa040120.43685737
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43622332
119Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43360737
120TGF-beta signaling pathway_Homo sapiens_hsa043500.43250704
121beta-Alanine metabolism_Homo sapiens_hsa004100.43111338
122Adherens junction_Homo sapiens_hsa045200.42568558
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42496987
124Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41632082
125Maturity onset diabetes of the young_Homo sapiens_hsa049500.41584350
126Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.40583490
127Endometrial cancer_Homo sapiens_hsa052130.40348442
128Melanogenesis_Homo sapiens_hsa049160.39633101
129Sphingolipid metabolism_Homo sapiens_hsa006000.39426248
130Pancreatic secretion_Homo sapiens_hsa049720.38643020
131Cardiac muscle contraction_Homo sapiens_hsa042600.38026197
132Cysteine and methionine metabolism_Homo sapiens_hsa002700.37601854
133ABC transporters_Homo sapiens_hsa020100.37601387
134Gap junction_Homo sapiens_hsa045400.37036482

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