ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of tolerance induction (GO:0002645)	8.80797767
2	regulation of regulatory T cell differentiation (GO:0045589)	8.68880606
3	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	8.00334172
4	regulation of T cell tolerance induction (GO:0002664)	7.57694851
5	regulation of tolerance induction (GO:0002643)	6.80080866
6	positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:00360	5.75193718
7	regulation of memory T cell differentiation (GO:0043380)	5.52123475
8	regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:0043	4.86978294
9	regulation of MHC class I biosynthetic process (GO:0045343)	4.83360383
10	negative regulation of type 2 immune response (GO:0002829)	4.81460088
11	hypotonic response (GO:0006971)	4.70793811
12	positive regulation of T cell mediated cytotoxicity (GO:0001916)	4.39802530
13	T-helper 1 type immune response (GO:0042088)	4.23288951
14	regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)	4.16604192
15	negative regulation of toll-like receptor signaling pathway (GO:0034122)	4.15659137
16	regulation of T cell mediated cytotoxicity (GO:0001914)	3.81901676
17	histone H3-K4 trimethylation (GO:0080182)	3.75269720
18	positive regulation of Cdc42 GTPase activity (GO:0043089)	3.69076457
19	regulation of interleukin-13 production (GO:0032656)	3.67958600
20	mitochondrial calcium ion transport (GO:0006851)	3.57419983
21	macrophage activation involved in immune response (GO:0002281)	3.37059621
22	detection of molecule of bacterial origin (GO:0032490)	3.35350930
23	ovulation (GO:0030728)	3.30483490
24	establishment of protein localization to Golgi (GO:0072600)	3.30383662
25	response to protozoan (GO:0001562)	3.28259352
26	coronary vasculature morphogenesis (GO:0060977)	3.21782813
27	positive regulation of interleukin-12 production (GO:0032735)	3.18973071
28	negative regulation of potassium ion transmembrane transporter activity (GO:1901017)	3.18825151
29	positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)	3.15702401
30	positive regulation of gamma-delta T cell activation (GO:0046645)	3.13548271
31	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	3.10558439
32	filopodium assembly (GO:0046847)	3.08832334
33	interferon-gamma production (GO:0032609)	3.06292055
34	cellular extravasation (GO:0045123)	3.05952486
35	positive regulation by symbiont of host defense response (GO:0052509)	3.05006608
36	modulation by symbiont of host defense response (GO:0052031)	3.05006608
37	modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00	3.05006608
38	modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0	3.05006608
39	positive regulation by organism of defense response of other organism involved in symbiotic interact	3.05006608
40	modulation by symbiont of host immune response (GO:0052553)	3.05006608
41	protein targeting to Golgi (GO:0000042)	3.00088360
42	defense response to protozoan (GO:0042832)	2.97915423
43	regulation of toll-like receptor signaling pathway (GO:0034121)	2.95818815
44	regulation of interleukin-5 production (GO:0032674)	2.93337244
45	cytoplasmic sequestering of transcription factor (GO:0042994)	2.92380796
46	regulation of type 2 immune response (GO:0002828)	2.90560599
47	nephron tubule formation (GO:0072079)	2.89484497
48	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.86314609
49	negative regulation of peptidyl-threonine phosphorylation (GO:0010801)	2.81722181
50	positive regulation of T cell chemotaxis (GO:0010820)	2.81454903
51	regulation of T cell chemotaxis (GO:0010819)	2.81454903
52	positive regulation of p38MAPK cascade (GO:1900745)	2.76186282
53	negative regulation of T cell differentiation (GO:0045581)	2.73757122
54	macrophage activation (GO:0042116)	2.68438795
55	nitric oxide mediated signal transduction (GO:0007263)	2.66476343
56	response to type I interferon (GO:0034340)	2.66375490
57	regulation of interleukin-12 production (GO:0032655)	2.65457361
58	I-kappaB kinase/NF-kappaB signaling (GO:0007249)	2.64359264
59	regulation of interferon-beta biosynthetic process (GO:0045357)	2.60952242
60	TOR signaling (GO:0031929)	2.60910719
61	negative regulation of potassium ion transmembrane transport (GO:1901380)	2.60217629
62	type I interferon signaling pathway (GO:0060337)	2.56936700
63	cellular response to type I interferon (GO:0071357)	2.56936700
64	interferon-gamma secretion (GO:0072643)	2.54075592
65	microglial cell activation (GO:0001774)	2.49715886
66	macroautophagy (GO:0016236)	2.48933403
67	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.48429123
68	peptidyl-lysine trimethylation (GO:0018023)	2.47760933
69	positive regulation of membrane protein ectodomain proteolysis (GO:0051044)	2.45793787
70	regulation of mast cell degranulation (GO:0043304)	2.45247496
71	cellular response to ethanol (GO:0071361)	2.44294547
72	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	2.43665287
73	negative regulation of T-helper cell differentiation (GO:0045623)	2.43665287
74	positive regulation of T cell mediated immunity (GO:0002711)	2.43483965
75	negative regulation of vascular permeability (GO:0043116)	2.41918663
76	cell morphogenesis involved in neuron differentiation (GO:0048667)	2.41049148
77	negative regulation of leukocyte differentiation (GO:1902106)	2.39699985
78	urogenital system development (GO:0001655)	2.39258363
79	regulation of DNA-templated transcription in response to stress (GO:0043620)	2.38983844
80	negative regulation of granulocyte differentiation (GO:0030853)	2.38443366
81	response to muramyl dipeptide (GO:0032495)	2.36960152
82	regulation of mast cell activation involved in immune response (GO:0033006)	2.36912010
83	positive regulation of mast cell activation involved in immune response (GO:0033008)	2.36762678
84	positive regulation of mast cell degranulation (GO:0043306)	2.36762678
85	regulation of p38MAPK cascade (GO:1900744)	2.35678064
86	regulation of B cell receptor signaling pathway (GO:0050855)	2.34442038
87	mannose metabolic process (GO:0006013)	2.34205085
88	atrioventricular valve morphogenesis (GO:0003181)	2.33855797
89	positive regulation of mast cell activation (GO:0033005)	2.33527970
90	regulation of myeloid leukocyte mediated immunity (GO:0002886)	2.32539074
91	barbed-end actin filament capping (GO:0051016)	2.32041036
92	interferon-gamma-mediated signaling pathway (GO:0060333)	2.31955376
93	regulation of transcription from RNA polymerase II promoter in response to stress (GO:0043618)	2.31933957
94	regulation of gamma-delta T cell activation (GO:0046643)	2.31779024
95	negative regulation of T cell activation (GO:0050868)	2.31023716
96	myelin maintenance (GO:0043217)	2.30825326
97	negative regulation of tumor necrosis factor production (GO:0032720)	2.30545780
98	positive regulation of myeloid leukocyte mediated immunity (GO:0002888)	2.28796884
99	negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)	2.26544717
100	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	10.1344818

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.11588351
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.05292393
3	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.90367020
4	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.81483388
5	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.69466906
6	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.78858043
7	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.54318671
8	SMAD_19615063_ChIP-ChIP_OVARY_Human	2.34634665
9	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.22520569
10	MYB_21317192_ChIP-Seq_ERMYB_Mouse	2.10829327
11	RUNX_20019798_ChIP-Seq_JUKART_Human	2.06788048
12	SCL_19346495_ChIP-Seq_HPC-7_Human	1.98760258
13	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.94851072
14	IRF8_27001747_Chip-Seq_BMDM_Mouse	1.91945130
15	VDR_24787735_ChIP-Seq_THP-1_Human	1.84885199
16	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.71976258
17	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.69600932
18	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	1.64786500
19	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.61448337
20	TCF7_22412390_ChIP-Seq_EML_Mouse	1.60939406
21	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.59553764
22	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	1.57022786
23	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.53789139
24	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.53398645
25	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	1.52824349
26	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.50157117
27	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.48945903
28	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.48592572
29	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.47504550
30	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.47139947
31	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.46014664
32	VDR_24763502_ChIP-Seq_THP-1_Human	1.45972748
33	DROSHA_22980978_ChIP-Seq_HELA_Human	1.44042137
34	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.43480421
35	FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse	1.41935728
36	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.40433747
37	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.39661092
38	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.38338780
39	GATA1_19941826_ChIP-Seq_K562_Human	1.37328921
40	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.37033570
41	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.36757220
42	MYB_26560356_Chip-Seq_TH1_Human	1.32873982
43	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.32796184
44	TP53_16413492_ChIP-PET_HCT116_Human	1.30906142
45	SPI1_23127762_ChIP-Seq_K562_Human	1.29960608
46	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.27424960
47	BRD4_27068464_Chip-Seq_AML-cells_Mouse	1.27304270
48	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.23289501
49	VDR_21846776_ChIP-Seq_THP-1_Human	1.21128800
50	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.17683925
51	AHR_22903824_ChIP-Seq_MCF-7_Human	1.17576753
52	BRD4_25478319_ChIP-Seq_HGPS_Human	1.17327185
53	KDM2B_26808549_Chip-Seq_DND41_Human	1.17323182
54	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.15626560
55	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.14714906
56	KLF5_25053715_ChIP-Seq_YYC3_Human	1.14435866
57	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.14043305
58	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.13999696
59	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.13379060
60	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.12917833
61	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.10384637
62	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.10285337
63	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.10113114
64	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.09573986
65	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	1.08914609
66	CJUN_26792858_Chip-Seq_BT549_Human	1.08195795
67	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.07964785
68	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.07578278
69	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.07000044
70	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.06673803
71	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.04627191
72	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	1.03518382
73	GATA1_19941827_ChIP-Seq_MEL_Mouse	1.03518290
74	MYB_26560356_Chip-Seq_TH2_Human	0.99972939
75	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	0.96877162
76	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.94836709
77	MAF_26560356_Chip-Seq_TH1_Human	0.94135919
78	TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse	0.93615780
79	RXR_22108803_ChIP-Seq_LS180_Human	0.92289305
80	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	0.92083617
81	FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human	0.91583413
82	KDM2B_26808549_Chip-Seq_JURKAT_Human	0.91515539
83	ELK3_25401928_ChIP-Seq_HUVEC_Human	0.90484791
84	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	0.88169245
85	PU_27001747_Chip-Seq_BMDM_Mouse	0.85949494
86	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.84030989
87	MAF_26560356_Chip-Seq_TH2_Human	0.83791215
88	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	0.83774391
89	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.83728438
90	GATA1_19941827_ChIP-Seq_MEL86_Mouse	0.83498453
91	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	0.82658639
92	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.81920366
93	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.80338413
94	KDM2B_26808549_Chip-Seq_REH_Human	0.78864060
95	KDM2B_26808549_Chip-Seq_K562_Human	0.78761597
96	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.78257338
97	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.76956015
98	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	0.75858814
99	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	0.75858814
100	NFIB_24661679_ChIP-Seq_LUNG_Mouse	0.75748215

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	4.48125713
2	MP0000013_abnormal_adipose_tissue	3.77472715
3	MP0005670_abnormal_white_adipose	3.41366346
4	MP0005645_abnormal_hypothalamus_physiol	3.20510492
5	MP0005076_abnormal_cell_differentiation	3.04668296
6	MP0005083_abnormal_biliary_tract	2.82376676
7	MP0004381_abnormal_hair_follicle	2.52069016
8	MP0001851_eye_inflammation	2.48987139
9	MP0000372_irregular_coat_pigmentation	2.23059542
10	MP0001835_abnormal_antigen_presentation	2.05818004
11	MP0002396_abnormal_hematopoietic_system	2.04185438
12	MP0000685_abnormal_immune_system	2.03139738
13	MP0005387_immune_system_phenotype	1.98630141
14	MP0001790_abnormal_immune_system	1.98630141
15	MP0003724_increased_susceptibility_to	1.97648633
16	MP0000015_abnormal_ear_pigmentation	1.92219368
17	MP0002419_abnormal_innate_immunity	1.88710989
18	MP0009764_decreased_sensitivity_to	1.83508482
19	MP0001502_abnormal_circadian_rhythm	1.81350654
20	MP0000003_abnormal_adipose_tissue	1.80947788
21	MP0003436_decreased_susceptibility_to	1.67952837
22	MP0001800_abnormal_humoral_immune	1.67391486
23	MP0005464_abnormal_platelet_physiology	1.66446337
24	MP0005025_abnormal_response_to	1.66206337
25	MP0005174_abnormal_tail_pigmentation	1.66018269
26	MP0005375_adipose_tissue_phenotype	1.65437272
27	MP0002877_abnormal_melanocyte_morpholog	1.60002148
28	MP0004019_abnormal_vitamin_homeostasis	1.56153008
29	MP0002095_abnormal_skin_pigmentation	1.55949993
30	MP0005671_abnormal_response_to	1.55327214
31	MP0002723_abnormal_immune_serum	1.54945175
32	MP0003959_abnormal_lean_body	1.53123779
33	MP0003303_peritoneal_inflammation	1.50846425
34	MP0003172_abnormal_lysosome_physiology	1.45881653
35	MP0008260_abnormal_autophagy	1.45732334
36	MP0002998_abnormal_bone_remodeling	1.43112860
37	MP0003828_pulmonary_edema	1.42414552
38	MP0002452_abnormal_antigen_presenting	1.41808993
39	MP0005164_abnormal_response_to	1.40486466
40	MP0003091_abnormal_cell_migration	1.37312398
41	MP0003045_fibrosis	1.35939007
42	MP0005253_abnormal_eye_physiology	1.35689320
43	MP0004272_abnormal_basement_membrane	1.33088540
44	MP0000371_diluted_coat_color	1.30546356
45	MP0002405_respiratory_system_inflammati	1.30274818
46	MP0004883_abnormal_blood_vessel	1.28810354
47	MP0003646_muscle_fatigue	1.28567843
48	MP0005023_abnormal_wound_healing	1.28460641
49	MP0004808_abnormal_hematopoietic_stem	1.28363460
50	MP0002420_abnormal_adaptive_immunity	1.26194665
51	MP0003656_abnormal_erythrocyte_physiolo	1.24655767
52	MP0001819_abnormal_immune_cell	1.23763380
53	MP0004947_skin_inflammation	1.19601479
54	MP0002332_abnormal_exercise_endurance	1.19514456
55	MP0003136_yellow_coat_color	1.16442342
56	MP0009785_altered_susceptibility_to	1.11654982
57	MP0003566_abnormal_cell_adhesion	1.10445758
58	MP0003638_abnormal_response/metabolism_	1.07859746
59	MP0001879_abnormal_lymphatic_vessel	1.04430637
60	MP0004084_abnormal_cardiac_muscle	1.03741715
61	MP0003252_abnormal_bile_duct	1.03659411
62	MP0002138_abnormal_hepatobiliary_system	1.03569738
63	MP0005397_hematopoietic_system_phenotyp	1.03469198
64	MP0001545_abnormal_hematopoietic_system	1.03469198
65	MP0005334_abnormal_fat_pad	1.02716693
66	MP0002148_abnormal_hypersensitivity_rea	1.01843488
67	MP0005171_absent_coat_pigmentation	1.01504057
68	MP0000249_abnormal_blood_vessel	1.00942640
69	MP0004133_heterotaxia	1.00201893
70	MP0003866_abnormal_defecation	0.99955707
71	MP0004036_abnormal_muscle_relaxation	0.98488205
72	MP0009278_abnormal_bone_marrow	0.98113909
73	MP0000716_abnormal_immune_system	0.95499326
74	MP0008961_abnormal_basal_metabolism	0.94241735
75	MP0001958_emphysema	0.93708355
76	MP0002398_abnormal_bone_marrow	0.93305903
77	MP0004510_myositis	0.91551299
78	MP0003763_abnormal_thymus_physiology	0.89707511
79	MP0010307_abnormal_tumor_latency	0.89163641
80	MP0002277_abnormal_respiratory_mucosa	0.88643855
81	MP0001845_abnormal_inflammatory_respons	0.88109164
82	MP0005058_abnormal_lysosome_morphology	0.85538747
83	MP0001533_abnormal_skeleton_physiology	0.85528754
84	MP0005000_abnormal_immune_tolerance	0.84752359
85	MP0005075_abnormal_melanosome_morpholog	0.82722946
86	MP0000733_abnormal_muscle_development	0.82705469
87	MP0005410_abnormal_fertilization	0.81939265
88	MP0005409_darkened_coat_color	0.81833490
89	MP0002168_other_aberrant_phenotype	0.80880006
90	MP0005666_abnormal_adipose_tissue	0.79404720
91	MP0003453_abnormal_keratinocyte_physiol	0.76189292
92	MP0002722_abnormal_immune_system	0.74872055
93	MP0000689_abnormal_spleen_morphology	0.73293090
94	MP0003631_nervous_system_phenotype	0.72936842
95	MP0009046_muscle_twitch	0.72134612
96	MP0000427_abnormal_hair_cycle	0.71504692
97	MP0002075_abnormal_coat/hair_pigmentati	0.71288767
98	MP0003633_abnormal_nervous_system	0.69937467
99	MP0001270_distended_abdomen	0.69911677
100	MP0000678_abnormal_parathyroid_gland	0.69152961

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	4.46458642
2	Colitis (HP:0002583)	4.07030600
3	Absence seizures (HP:0002121)	4.02165581
4	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	3.92369396
5	Hypoplastic ischia (HP:0003175)	3.88077565
6	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	3.69047254
7	Genetic anticipation (HP:0003743)	3.47357834
8	Recurrent abscess formation (HP:0002722)	3.37406841
9	Persistence of primary teeth (HP:0006335)	3.34765719
10	Abnormality of the ischium (HP:0003174)	3.32420449
11	Recurrent bacterial skin infections (HP:0005406)	2.98517016
12	Congenital stationary night blindness (HP:0007642)	2.97499403
13	Postural instability (HP:0002172)	2.91244288
14	Abnormality of the nasal septum (HP:0000419)	2.84680684
15	Dialeptic seizures (HP:0011146)	2.81205215
16	Cellulitis (HP:0100658)	2.74221826
17	Natal tooth (HP:0000695)	2.73922677
18	Eczematoid dermatitis (HP:0000976)	2.69778496
19	Inflammation of the large intestine (HP:0002037)	2.65359251
20	Agammaglobulinemia (HP:0004432)	2.58721167
21	Recurrent bronchitis (HP:0002837)	2.56707322
22	Long clavicles (HP:0000890)	2.55975560
23	Abnormality of macular pigmentation (HP:0008002)	2.52719698
24	Slow saccadic eye movements (HP:0000514)	2.47873035
25	Abnormality of macrophages (HP:0004311)	2.46227684
26	Wrist flexion contracture (HP:0001239)	2.45065225
27	Segmental peripheral demyelination/remyelination (HP:0003481)	2.43294194
28	Deformed sella turcica (HP:0002681)	2.41642413
29	Lip pit (HP:0100267)	2.39306176
30	Gastrointestinal inflammation (HP:0004386)	2.34289877
31	Increased connective tissue (HP:0009025)	2.33654783
32	Gingivitis (HP:0000230)	2.33629328
33	T lymphocytopenia (HP:0005403)	2.32952264
34	Abnormality of liposaccharide metabolism (HP:0010968)	2.32489067
35	Abnormality of glycosphingolipid metabolism (HP:0004343)	2.32489067
36	Abnormality of glycolipid metabolism (HP:0010969)	2.32489067
37	Abnormality of the sella turcica (HP:0002679)	2.30712230
38	Meningitis (HP:0001287)	2.23840251
39	Hypoplastic iliac wings (HP:0002866)	2.23122020
40	Optic neuritis (HP:0100653)	2.21579130
41	Retrobulbar optic neuritis (HP:0100654)	2.21579130
42	Glucose intolerance (HP:0000833)	2.20218441
43	Abnormality of the fingertips (HP:0001211)	2.19596395
44	Onion bulb formation (HP:0003383)	2.19440228
45	Peritonitis (HP:0002586)	2.17252195
46	Abnormality of the pubic bones (HP:0003172)	2.16757922
47	Dislocated radial head (HP:0003083)	2.16075872
48	Fibular aplasia (HP:0002990)	2.15235720
49	Aplasia/Hypoplasia of the macula (HP:0008059)	2.15194236
50	Vacuolated lymphocytes (HP:0001922)	2.13698372
51	Recurrent gram-negative bacterial infections (HP:0005420)	2.13501917
52	Orchitis (HP:0100796)	2.13493683
53	Ocular albinism (HP:0001107)	2.12788583
54	Protruding tongue (HP:0010808)	2.12448643
55	Mask-like facies (HP:0000298)	2.09107442
56	Abnormality of T cell number (HP:0011839)	2.07271884
57	Bell-shaped thorax (HP:0001591)	2.07076664
58	Long eyelashes (HP:0000527)	2.06850653
59	Recurrent pneumonia (HP:0006532)	2.05834704
60	Myositis (HP:0100614)	2.05538531
61	Tetany (HP:0001281)	2.05038924
62	Truncal obesity (HP:0001956)	2.03786450
63	Absent hand (HP:0004050)	2.03324866
64	Cardiovascular calcification (HP:0011915)	2.01140084
65	Vascular calcification (HP:0004934)	1.98298943
66	Nonprogressive disorder (HP:0003680)	1.98197681
67	Acute myeloid leukemia (HP:0004808)	1.97849102
68	Narrow palate (HP:0000189)	1.97454032
69	Osteomyelitis (HP:0002754)	1.94165048
70	Aplasia/Hypoplasia affecting the retina (HP:0008061)	1.93279159
71	Abnormality of the radial head (HP:0003995)	1.92434483
72	Severe short stature (HP:0003510)	1.91847013
73	Increased purine levels (HP:0004368)	1.91782153
74	Hyperuricemia (HP:0002149)	1.91782153
75	Distal lower limb amyotrophy (HP:0008944)	1.91689129
76	Flared iliac wings (HP:0002869)	1.91294709
77	Chronic sinusitis (HP:0011109)	1.90980915
78	Pustule (HP:0200039)	1.90559810
79	Abnormality of the parietal bone (HP:0002696)	1.90103658
80	Milia (HP:0001056)	1.90049441
81	Recurrent fungal infections (HP:0002841)	1.90006115
82	Gingival bleeding (HP:0000225)	1.89765623
83	Hypoplastic scapulae (HP:0000882)	1.89229599
84	Aplasia/Hypoplasia of the scapulae (HP:0006713)	1.89229599
85	Axonal loss (HP:0003447)	1.88152277
86	Abnormality of the columella (HP:0009929)	1.87781677
87	Mesomelia (HP:0003027)	1.87302794
88	Split foot (HP:0001839)	1.86946347
89	Glomerulonephritis (HP:0000099)	1.86017322
90	Abnormal glucose tolerance (HP:0001952)	1.85092845
91	Progressive cerebellar ataxia (HP:0002073)	1.85010854
92	Aortic aneurysm (HP:0004942)	1.83947035
93	Congenital sensorineural hearing impairment (HP:0008527)	1.82624773
94	Spontaneous hematomas (HP:0007420)	1.81885367
95	Abnormality of the phalanges of the hallux (HP:0010057)	1.81142989
96	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.80618438
97	Hypoplasia of the fovea (HP:0007750)	1.80618438
98	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.80466834
99	Right ventricular cardiomyopathy (HP:0011663)	1.79262111
100	Short 4th metacarpal (HP:0010044)	1.73427089

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK4	5.17029317
2	STK39	4.90876402
3	TESK2	4.34711403
4	WNK1	3.69673123
5	BRSK1	3.57256929
6	AKT3	2.25684145
7	MAP4K1	2.07572965
8	BLK	1.81118472
9	MARK2	1.80448066
10	CDC42BPA	1.78715712
11	MELK	1.74547896
12	MAPK11	1.64767907
13	TAOK3	1.63632030
14	FRK	1.58108420
15	ZAP70	1.56070735
16	IKBKE	1.55799037
17	CAMK1D	1.52970836
18	RIPK4	1.44203888
19	PIK3CG	1.34178007
20	CDK12	1.26017385
21	JAK3	1.24045722
22	MARK3	1.21378637
23	MAP3K7	1.19336820
24	EPHB2	1.19330169
25	GRK1	1.19323397
26	CAMK1G	1.19304431
27	SGK223	1.18901371
28	SGK494	1.18901371
29	IRAK1	1.15572227
30	STK38	1.08314159
31	ERBB2	1.02856235
32	CSK	1.00174565
33	MAP2K3	0.98726282
34	PTK2B	0.96946524
35	SGK2	0.96195398
36	MAP3K1	0.96037071
37	MTOR	0.95635303
38	IRAK4	0.94601266
39	TRPM7	0.91058363
40	CHUK	0.90543190
41	ACVR1B	0.90541156
42	DMPK	0.90486484
43	SIK1	0.90315029
44	MAP3K14	0.89765951
45	MAP3K13	0.88093738
46	BTK	0.87983618
47	IRAK2	0.87365586
48	FES	0.85893431
49	PDGFRB	0.85892420
50	MAPK7	0.81521218
51	KSR1	0.78513433
52	SYK	0.77189688
53	RIPK1	0.76209211
54	IKBKB	0.76112681
55	TRIB3	0.72703747
56	TYK2	0.72679249
57	DDR2	0.72043810
58	CAMK4	0.70046300
59	HCK	0.69368685
60	PRKD2	0.68607325
61	LYN	0.68028276
62	STK10	0.67296976
63	HIPK2	0.63488299
64	KIT	0.60128303
65	PIM1	0.60086426
66	PRKCQ	0.59852769
67	SGK3	0.58743890
68	MAP3K2	0.58724379
69	PRKAA2	0.57659057
70	GRK6	0.57483525
71	CAMK1	0.57431962
72	MAP3K3	0.56754172
73	PKN1	0.56513410
74	IGF1R	0.56005508
75	ITK	0.53832257
76	TEC	0.53824319
77	FGR	0.53485825
78	TBK1	0.52273217
79	FGFR3	0.52166979
80	ICK	0.47771174
81	SGK1	0.47611964
82	CSF1R	0.46805643
83	MAPK12	0.46293258
84	PTK2	0.44376391
85	TLK1	0.41378642
86	MAPKAPK2	0.41269611
87	RPS6KA1	0.41040587
88	EPHB1	0.40859442
89	TGFBR2	0.40643656
90	ADRBK1	0.40346832
91	DAPK2	0.40249040
92	DYRK1B	0.39930819
93	MAP3K11	0.37861206
94	MAPK1	0.36878705
95	TNK2	0.36613008
96	TXK	0.36173955
97	NLK	0.35467540
98	SIK2	0.35186376
99	MAP3K8	0.35136950
100	MAP3K6	0.34388033

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Graft-versus-host disease_Homo sapiens_hsa05332	2.63648344
2	Allograft rejection_Homo sapiens_hsa05330	2.60146760
3	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.54298766
4	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	2.07545343
5	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.06970502
6	Type I diabetes mellitus_Homo sapiens_hsa04940	1.99409966
7	Viral myocarditis_Homo sapiens_hsa05416	1.92175287
8	Osteoclast differentiation_Homo sapiens_hsa04380	1.85363024
9	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.71638845
10	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.56374581
11	Leishmaniasis_Homo sapiens_hsa05140	1.52477883
12	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.45869543
13	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	1.42507368
14	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.42141317
15	Antigen processing and presentation_Homo sapiens_hsa04612	1.40895035
16	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.29586220
17	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.28580802
18	Jak-STAT signaling pathway_Homo sapiens_hsa04630	1.25556120
19	Notch signaling pathway_Homo sapiens_hsa04330	1.24901485
20	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.23046100
21	Acute myeloid leukemia_Homo sapiens_hsa05221	1.22792863
22	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.22334255
23	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	1.21614390
24	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.20341039
25	HIF-1 signaling pathway_Homo sapiens_hsa04066	1.20207727
26	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.18570231
27	Influenza A_Homo sapiens_hsa05164	1.18295940
28	mTOR signaling pathway_Homo sapiens_hsa04150	1.17033015
29	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	1.14381064
30	Renal cell carcinoma_Homo sapiens_hsa05211	1.14060328
31	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.09223741
32	TNF signaling pathway_Homo sapiens_hsa04668	1.07194620
33	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	1.07140383
34	Legionellosis_Homo sapiens_hsa05134	1.06026664
35	Malaria_Homo sapiens_hsa05144	1.05427742
36	Lysine degradation_Homo sapiens_hsa00310	1.04237952
37	Toxoplasmosis_Homo sapiens_hsa05145	1.03268771
38	Tuberculosis_Homo sapiens_hsa05152	1.02105530
39	Pancreatic cancer_Homo sapiens_hsa05212	1.00656374
40	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.99228793
41	Phagosome_Homo sapiens_hsa04145	0.95150408
42	Other glycan degradation_Homo sapiens_hsa00511	0.94539795
43	Herpes simplex infection_Homo sapiens_hsa05168	0.93983235
44	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.89358296
45	Hepatitis C_Homo sapiens_hsa05160	0.88184440
46	VEGF signaling pathway_Homo sapiens_hsa04370	0.86549104
47	Measles_Homo sapiens_hsa05162	0.86486971
48	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.85014832
49	Non-small cell lung cancer_Homo sapiens_hsa05223	0.84425100
50	Platelet activation_Homo sapiens_hsa04611	0.82373395
51	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.81804086
52	Chemokine signaling pathway_Homo sapiens_hsa04062	0.81654243
53	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.79666791
54	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.78278970
55	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.78169660
56	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.77985343
57	Viral carcinogenesis_Homo sapiens_hsa05203	0.77845933
58	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.77795765
59	FoxO signaling pathway_Homo sapiens_hsa04068	0.75950855
60	MicroRNAs in cancer_Homo sapiens_hsa05206	0.74995893
61	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.74947670
62	Amoebiasis_Homo sapiens_hsa05146	0.74496925
63	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.74249324
64	Phototransduction_Homo sapiens_hsa04744	0.73822034
65	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.73709109
66	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.72247854
67	Endocytosis_Homo sapiens_hsa04144	0.71777332
68	Prolactin signaling pathway_Homo sapiens_hsa04917	0.71205031
69	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.71008516
70	Type II diabetes mellitus_Homo sapiens_hsa04930	0.69829620
71	ErbB signaling pathway_Homo sapiens_hsa04012	0.67968606
72	GnRH signaling pathway_Homo sapiens_hsa04912	0.67046419
73	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.66982970
74	MAPK signaling pathway_Homo sapiens_hsa04010	0.66370523
75	African trypanosomiasis_Homo sapiens_hsa05143	0.66027576
76	Apoptosis_Homo sapiens_hsa04210	0.64529422
77	Focal adhesion_Homo sapiens_hsa04510	0.64075519
78	HTLV-I infection_Homo sapiens_hsa05166	0.63037375
79	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.59888018
80	Hepatitis B_Homo sapiens_hsa05161	0.59735546
81	Small cell lung cancer_Homo sapiens_hsa05222	0.58235925
82	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.57676519
83	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.56601175
84	Choline metabolism in cancer_Homo sapiens_hsa05231	0.55142664
85	Rap1 signaling pathway_Homo sapiens_hsa04015	0.53920679
86	Proteoglycans in cancer_Homo sapiens_hsa05205	0.53139800
87	Pathways in cancer_Homo sapiens_hsa05200	0.53097308
88	Adherens junction_Homo sapiens_hsa04520	0.52832212
89	Tight junction_Homo sapiens_hsa04530	0.51983859
90	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.51665340
91	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.51121303
92	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.50948099
93	Insulin resistance_Homo sapiens_hsa04931	0.50337180
94	Circadian entrainment_Homo sapiens_hsa04713	0.48782757
95	Calcium signaling pathway_Homo sapiens_hsa04020	0.48325198
96	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.47542784
97	ECM-receptor interaction_Homo sapiens_hsa04512	0.47433957
98	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.47158270
99	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.46834533
100	AMPK signaling pathway_Homo sapiens_hsa04152	0.46631289

CEP295NL

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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