CEP350

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene is a large protein with a CAP-Gly domain typically found in cytoskeleton-associated proteins. The encoded protein primarily localizes to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. The encoded protein directly interacts with another large centrosomal protein and is required to anchor microtubules at the centrosome. It is also implicated in the regulation of a class of nuclear hormone receptors in the nucleus. Several alternatively spliced transcript variants have been found, but their full-length nature has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)5.73061664
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.60380634
3pore complex assembly (GO:0046931)5.00487627
4interkinetic nuclear migration (GO:0022027)4.93412280
5positive regulation of gamma-delta T cell activation (GO:0046645)4.81189730
6sister chromatid cohesion (GO:0007062)4.01095140
7cellular response to ethanol (GO:0071361)4.00338599
8nucleus localization (GO:0051647)3.90649413
9regulation of interleukin-12 biosynthetic process (GO:0045075)3.83762419
10cytoplasmic mRNA processing body assembly (GO:0033962)3.77365011
11peptidyl-lysine methylation (GO:0018022)3.68322054
12regulation of pigment cell differentiation (GO:0050932)3.67110214
13regulation of DNA endoreduplication (GO:0032875)3.64830076
14DNA synthesis involved in DNA repair (GO:0000731)3.63097407
15Golgi to endosome transport (GO:0006895)3.61453605
16positive regulation by symbiont of host defense response (GO:0052509)3.61180924
17modulation by symbiont of host defense response (GO:0052031)3.61180924
18modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.61180924
19modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.61180924
20positive regulation by organism of defense response of other organism involved in symbiotic interact3.61180924
21modulation by symbiont of host immune response (GO:0052553)3.61180924
22histone mRNA catabolic process (GO:0071044)3.60081965
23regulation of RNA export from nucleus (GO:0046831)3.59569392
24negative regulation of cell killing (GO:0031342)3.58986670
25negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.58986670
26regulation of interferon-beta biosynthetic process (GO:0045357)3.57406522
27negative regulation of DNA repair (GO:0045738)3.56888900
28regulation of establishment of cell polarity (GO:2000114)3.56541927
29regulation of gamma-delta T cell activation (GO:0046643)3.53168474
30positive regulation of histone deacetylation (GO:0031065)3.51820391
31negative regulation of neurotransmitter secretion (GO:0046929)3.48540400
32regulation of gamma-delta T cell differentiation (GO:0045586)3.47096581
33synapsis (GO:0007129)3.45863850
34antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.38878824
35antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.38878824
36genitalia morphogenesis (GO:0035112)3.35341935
37regulation of centriole replication (GO:0046599)3.28914269
38embryonic retina morphogenesis in camera-type eye (GO:0060059)3.28747697
39establishment of nucleus localization (GO:0040023)3.27306061
40histone H3-K9 methylation (GO:0051567)3.25405400
41positive regulation of developmental pigmentation (GO:0048087)3.21482650
42protein K48-linked deubiquitination (GO:0071108)3.21330408
43antigen processing and presentation of endogenous antigen (GO:0019883)3.21181348
44positive regulation of mitotic sister chromatid separation (GO:1901970)3.20881039
45positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.20881039
46positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.20881039
47protein K11-linked deubiquitination (GO:0035871)3.20255032
48protein prenylation (GO:0018342)3.18779092
49prenylation (GO:0097354)3.18779092
50histone H3-K4 trimethylation (GO:0080182)3.18453775
51protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)3.15231209
52histone H3-K9 modification (GO:0061647)3.08395060
53mitotic sister chromatid cohesion (GO:0007064)3.08208747
54regulation of histone H3-K9 methylation (GO:0051570)3.08171256
55response to muramyl dipeptide (GO:0032495)3.08114777
56regulation of protein polyubiquitination (GO:1902914)3.08037004
57positive regulation of natural killer cell differentiation (GO:0032825)3.07208630
58histone lysine demethylation (GO:0070076)3.06497848
59* microtubule anchoring (GO:0034453)3.06432085
60positive thymic T cell selection (GO:0045059)3.05720241
61growth hormone receptor signaling pathway (GO:0060396)3.05636636
62centriole replication (GO:0007099)3.05309793
63hepatocyte apoptotic process (GO:0097284)3.04386412
64retrograde transport, vesicle recycling within Golgi (GO:0000301)3.02899756
65positive regulation of interferon-alpha production (GO:0032727)3.02223763
66histone-serine phosphorylation (GO:0035404)3.01739275
67NIK/NF-kappaB signaling (GO:0038061)3.00283233
68protein localization to Golgi apparatus (GO:0034067)2.98346061
69I-kappaB phosphorylation (GO:0007252)2.97924269
70histone demethylation (GO:0016577)2.97054085
71positive regulation of granulocyte differentiation (GO:0030854)2.95723771
72positive regulation of B cell differentiation (GO:0045579)2.92408884
73negative thymic T cell selection (GO:0045060)2.91525907
74protein K63-linked deubiquitination (GO:0070536)2.91457937
75negative T cell selection (GO:0043383)2.89881262
76negative regulation of neurotransmitter transport (GO:0051589)2.89515391
77establishment of protein localization to Golgi (GO:0072600)2.87798460
78macrophage activation involved in immune response (GO:0002281)2.86268298
79early endosome to late endosome transport (GO:0045022)2.85711116
80regulation of establishment or maintenance of cell polarity (GO:0032878)2.85658895
81regulation of interferon-alpha production (GO:0032647)2.85205685
82regulation of nucleobase-containing compound transport (GO:0032239)2.82975559
83snRNA transcription (GO:0009301)2.82429558
84neural tube formation (GO:0001841)2.81768782
85TOR signaling (GO:0031929)2.81632459
86phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.81313013
87protein targeting to vacuole (GO:0006623)2.80842074
88protein targeting to lysosome (GO:0006622)2.80842074
89establishment of protein localization to vacuole (GO:0072666)2.80842074
90regulation of centrosome duplication (GO:0010824)2.80130276
91centrosome duplication (GO:0051298)2.79832723
92positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.79743160
93histone H3-K9 demethylation (GO:0033169)2.77642217
94cellular extravasation (GO:0045123)2.75555220
95protein targeting to Golgi (GO:0000042)2.71221536
96centrosome localization (GO:0051642)2.70121238
97peptidyl-lysine dimethylation (GO:0018027)2.68666477
98regulation of histone H3-K27 methylation (GO:0061085)2.68626173
99positive regulation of DNA-templated transcription, initiation (GO:2000144)2.68385463
100positive T cell selection (GO:0043368)2.67133720
101natural killer cell mediated cytotoxicity (GO:0042267)2.67131248
102natural killer cell mediated immunity (GO:0002228)2.67131248
103peptidyl-threonine phosphorylation (GO:0018107)2.67027140
104microtubule nucleation (GO:0007020)2.66653908
105nuclear pore complex assembly (GO:0051292)2.64791106
106nucleus organization (GO:0006997)2.64693221
107N-terminal protein amino acid acetylation (GO:0006474)2.62029315
108cilium or flagellum-dependent cell motility (GO:0001539)2.61224546
109T cell migration (GO:0072678)2.61145845
110interleukin-6-mediated signaling pathway (GO:0070102)2.59813625
111regulation of necroptotic process (GO:0060544)2.58631302
112labyrinthine layer development (GO:0060711)2.58264569
113nerve growth factor signaling pathway (GO:0038180)2.57988555
114JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.57544486
115cellular response to growth hormone stimulus (GO:0071378)2.57435179
116chromosome organization involved in meiosis (GO:0070192)2.56470827
117oocyte development (GO:0048599)2.55580383
118intra-Golgi vesicle-mediated transport (GO:0006891)2.55553201
119peptidyl-threonine modification (GO:0018210)2.54054113
120histone H3-K4 methylation (GO:0051568)2.53596657
121response to type I interferon (GO:0034340)2.53259045
122protein demethylation (GO:0006482)2.52946848
123protein dealkylation (GO:0008214)2.52946848
124T cell selection (GO:0045058)2.52202704
125histone H3-K36 demethylation (GO:0070544)2.51909981
126response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.51462746
127response to host immune response (GO:0052572)2.51462746
128protein deubiquitination (GO:0016579)2.51419513
129regulation of protein glycosylation (GO:0060049)2.48892162
130regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.46423485
131positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.46423485
132thymic T cell selection (GO:0045061)2.46125007
133histone H4-K16 acetylation (GO:0043984)2.45308200
134pericardium development (GO:0060039)2.43950835
135type I interferon signaling pathway (GO:0060337)2.42863835
136cellular response to type I interferon (GO:0071357)2.42863835
137regulation of B cell differentiation (GO:0045577)2.41426450
138mature B cell differentiation (GO:0002335)2.41334873
139necroptotic process (GO:0070266)2.41072235
140NLS-bearing protein import into nucleus (GO:0006607)2.41070094
141macroautophagy (GO:0016236)2.40079968
142response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.39685611
143response to host (GO:0075136)2.39685611
144response to host defenses (GO:0052200)2.39685611
145phospholipid homeostasis (GO:0055091)2.39494217
146negative regulation of translation, ncRNA-mediated (GO:0040033)2.37874943
147regulation of translation, ncRNA-mediated (GO:0045974)2.37874943
148negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.37874943
149regulation of RIG-I signaling pathway (GO:0039535)2.37442486
150acrosome assembly (GO:0001675)2.36626153
151antigen processing and presentation via MHC class Ib (GO:0002475)2.36529242
152monoubiquitinated protein deubiquitination (GO:0035520)2.36042493
153corticosteroid receptor signaling pathway (GO:0031958)2.35971793
154lipid translocation (GO:0034204)2.35759945
155phospholipid translocation (GO:0045332)2.35759945
156negative regulation of granulocyte differentiation (GO:0030853)2.34064795
157peptidyl-lysine trimethylation (GO:0018023)2.33933145
158natural killer cell differentiation (GO:0001779)2.33931679
159striated muscle atrophy (GO:0014891)2.32310823
160regulation of B cell receptor signaling pathway (GO:0050855)2.31708982
161positive regulation of protein deacetylation (GO:0090312)2.31309237
162definitive hemopoiesis (GO:0060216)2.29933272
163regulation of T cell tolerance induction (GO:0002664)2.28159729
164CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.27192975
165histone lysine methylation (GO:0034968)2.25870963
166neutrophil activation (GO:0042119)2.25686254
167B cell homeostasis (GO:0001782)2.25217921
168regulation of mRNA catabolic process (GO:0061013)2.25089480
169pre-miRNA processing (GO:0031054)2.24671290
170positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.23644767
171regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.23644767
172regulation of histone deacetylation (GO:0031063)2.20824041
173negative regulation of histone methylation (GO:0031061)2.20653750
174seminiferous tubule development (GO:0072520)2.20136710
175positive regulation of interferon-beta production (GO:0032728)2.19390975
176necrotic cell death (GO:0070265)2.19024839
177positive regulation of cellular amide metabolic process (GO:0034250)2.18721336

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.25784533
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.22414702
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.99358994
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.15436728
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.02651133
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.91266194
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.87832698
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.76481277
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.76244767
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.66688226
11GATA1_22025678_ChIP-Seq_K562_Human2.55817848
12* IRF8_27001747_Chip-Seq_BMDM_Mouse2.55395385
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.51273562
14* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.51236724
15E2F7_22180533_ChIP-Seq_HELA_Human2.48859744
16RUNX_20019798_ChIP-Seq_JUKART_Human2.37600090
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.31750140
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.31109299
19* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.30705040
20SCL_19346495_ChIP-Seq_HPC-7_Human2.23155152
21* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.22370535
22GBX2_23144817_ChIP-Seq_PC3_Human2.21772804
23* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.18688143
24MYB_21317192_ChIP-Seq_ERMYB_Mouse2.16742502
25TAF15_26573619_Chip-Seq_HEK293_Human2.09047058
26FUS_26573619_Chip-Seq_HEK293_Human2.04707683
27KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.94934739
28TCF7_22412390_ChIP-Seq_EML_Mouse1.81458271
29SMAD_19615063_ChIP-ChIP_OVARY_Human1.79528146
30* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.77128805
31SMAD4_21799915_ChIP-Seq_A2780_Human1.77051526
32SPI1_23127762_ChIP-Seq_K562_Human1.76878758
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76276290
34* STAT3_23295773_ChIP-Seq_U87_Human1.74292565
35ER_23166858_ChIP-Seq_MCF-7_Human1.70505239
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.69160625
37* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.68110990
38MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.67222008
39* MYB_26560356_Chip-Seq_TH2_Human1.65780645
40EWS_26573619_Chip-Seq_HEK293_Human1.61969062
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.61906400
42* MYB_26560356_Chip-Seq_TH1_Human1.59100701
43* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.57207426
44* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.56403807
45P300_19829295_ChIP-Seq_ESCs_Human1.55845693
46MAF_26560356_Chip-Seq_TH1_Human1.54241245
47TCF4_23295773_ChIP-Seq_U87_Human1.54210861
48* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.52016642
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48590920
50E2F4_17652178_ChIP-ChIP_JURKAT_Human1.47203278
51* NANOG_18555785_Chip-Seq_ESCs_Mouse1.46267771
52* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46109745
53* PIAS1_25552417_ChIP-Seq_VCAP_Human1.45739226
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45085138
55SALL1_21062744_ChIP-ChIP_HESCs_Human1.44328169
56* EZH2_27294783_Chip-Seq_NPCs_Mouse1.43559160
57GATA2_21666600_ChIP-Seq_HMVEC_Human1.43306287
58FLI1_27457419_Chip-Seq_LIVER_Mouse1.43218083
59FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.42553608
60* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.41884414
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.41848203
62AR_21572438_ChIP-Seq_LNCaP_Human1.41429311
63VDR_24787735_ChIP-Seq_THP-1_Human1.41151903
64* E2F1_18555785_Chip-Seq_ESCs_Mouse1.39454482
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38494309
66IGF1R_20145208_ChIP-Seq_DFB_Human1.37424532
67* PU_27001747_Chip-Seq_BMDM_Mouse1.36509275
68GATA3_27048872_Chip-Seq_THYMUS_Human1.35036336
69MYC_22102868_ChIP-Seq_BL_Human1.34592395
70* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.34502044
71STAT4_19710469_ChIP-ChIP_TH1__Mouse1.31422962
72UTX_26944678_Chip-Seq_JUKART_Human1.29246968
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.28893966
74CBP_20019798_ChIP-Seq_JUKART_Human1.28687535
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28687535
76RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.28134290
77KDM2B_26808549_Chip-Seq_DND41_Human1.25972513
78VDR_24763502_ChIP-Seq_THP-1_Human1.25727911
79FLI1_21867929_ChIP-Seq_TH2_Mouse1.25675602
80PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25186960
81* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25092522
82* CMYC_18555785_Chip-Seq_ESCs_Mouse1.24908477
83PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24535878
84FOXO3_23340844_ChIP-Seq_DLD1_Human1.23926654
85HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.23821178
86TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.23256975
87* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.22236371
88SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21428310
89FOXA2_19822575_ChIP-Seq_HepG2_Human1.20829849
90SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20813897
91GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20805208
92NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.20685995
93CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.20215639
94* NFE2_27457419_Chip-Seq_LIVER_Mouse1.19974666
95E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.19168428
96CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19108296
97* RUNX1_22412390_ChIP-Seq_EML_Mouse1.19060194
98VDR_21846776_ChIP-Seq_THP-1_Human1.18063179
99* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.17816752
100* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.17659203
101BP1_19119308_ChIP-ChIP_Hs578T_Human1.17467551
102* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17418536
103TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.17378579
104ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17035081
105PCGF2_27294783_Chip-Seq_ESCs_Mouse1.16642643
106SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.16475511
107* P53_22387025_ChIP-Seq_ESCs_Mouse1.16215192
108BCAT_22108803_ChIP-Seq_LS180_Human1.15492851
109RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.14982522
110* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14595535
111* AR_25329375_ChIP-Seq_VCAP_Human1.13105804
112FOXM1_23109430_ChIP-Seq_U2OS_Human1.13051495
113GATA1_19941827_ChIP-Seq_MEL_Mouse1.12846423
114* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12800840
115RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12450587
116ESR1_20079471_ChIP-ChIP_T-47D_Human1.12148205
117NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12042455
118CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11340803
119PRDM14_20953172_ChIP-Seq_ESCs_Human1.10946135
120* P300_18555785_Chip-Seq_ESCs_Mouse1.09589295
121CDX2_22108803_ChIP-Seq_LS180_Human1.09329505
122RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09044061
123CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08825973
124PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08263792
125GATA1_19941826_ChIP-Seq_K562_Human1.07489517
126GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.07450497
127* GATA2_19941826_ChIP-Seq_K562_Human1.05882695
128* OCT4_18555785_Chip-Seq_ESCs_Mouse1.05152088
129FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04839757
130* CRX_20693478_ChIP-Seq_RETINA_Mouse1.04594902
131KDM2B_26808549_Chip-Seq_SUP-B15_Human1.03780942
132NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01328477
133NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01328477
134SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00778875
135WT1_19549856_ChIP-ChIP_CCG9911_Human1.00347920
136LXR_22158963_ChIP-Seq_LIVER_Mouse1.00086071
137* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.99801638
138PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99348181
139* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.98929350
140NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.97418141
141CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96021200
142RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.94363283
143* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93399132
144NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93358172
145ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92483037
146KDM2B_26808549_Chip-Seq_JURKAT_Human0.91818520
147* SPI1_23547873_ChIP-Seq_NB4_Human0.90723414
148KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.90486554
149TCF4_18268006_ChIP-ChIP_LS174T_Human0.90040463
150GATA2_22383799_ChIP-Seq_G1ME_Mouse0.89693015
151* GATA3_26560356_Chip-Seq_TH2_Human0.88867093
152DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.87968040
153RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.87660893
154CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.86294115
155STAT6_21828071_ChIP-Seq_BEAS2B_Human0.85973861
156GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85198398
157AHR_22903824_ChIP-Seq_MCF-7_Human0.84965141
158PPAR_26484153_Chip-Seq_NCI-H1993_Human0.83386564
159SOX9_24532713_ChIP-Seq_HFSC_Mouse0.83032229
160BRD4_25478319_ChIP-Seq_HGPS_Human0.82415401
161BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81988004
162TP53_16413492_ChIP-PET_HCT116_Human0.80616026
163* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.77873639
164SMRT_27268052_Chip-Seq_Bcells_Human0.77849898
165TBX20_22080862_ChIP-Seq_HEART_Mouse0.77793977
166TBX20_22328084_ChIP-Seq_HEART_Mouse0.77793977
167POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.77061293
168TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77061293
169ARNT_22903824_ChIP-Seq_MCF-7_Human0.76466251
170GATA6_25053715_ChIP-Seq_YYC3_Human0.76456151
171PKCTHETA_26484144_Chip-Seq_BREAST_Human0.76335741

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.73792602
2MP0003300_gastrointestinal_ulcer3.42873584
3MP0001835_abnormal_antigen_presentation3.02708732
4MP0002166_altered_tumor_susceptibility2.90423329
5MP0008877_abnormal_DNA_methylation2.78617854
6MP0000685_abnormal_immune_system2.39624849
7MP0001800_abnormal_humoral_immune2.31939039
8MP0004510_myositis2.28853458
9MP0003890_abnormal_embryonic-extraembry2.28366939
10MP0002006_tumorigenesis2.25588571
11MP0005076_abnormal_cell_differentiation2.25586076
12MP0003436_decreased_susceptibility_to2.25382759
13MP0001790_abnormal_immune_system2.24666165
14MP0005387_immune_system_phenotype2.24666165
15MP0003646_muscle_fatigue2.17469390
16MP0002396_abnormal_hematopoietic_system2.08033505
17MP0002452_abnormal_antigen_presenting2.01986655
18MP0010678_abnormal_skin_adnexa2.01285324
19MP0004808_abnormal_hematopoietic_stem2.01106310
20MP0009278_abnormal_bone_marrow2.01003380
21MP0003303_peritoneal_inflammation2.00651803
22MP0003045_fibrosis1.94389282
23MP0005671_abnormal_response_to1.93168821
24MP0005464_abnormal_platelet_physiology1.91706770
25MP0002419_abnormal_innate_immunity1.90229546
26MP0000383_abnormal_hair_follicle1.89912529
27MP0002723_abnormal_immune_serum1.88174199
28MP0000427_abnormal_hair_cycle1.86944688
29MP0005174_abnormal_tail_pigmentation1.83882548
30MP0005000_abnormal_immune_tolerance1.81022219
31MP0004947_skin_inflammation1.79721269
32MP0005025_abnormal_response_to1.78296662
33MP0010352_gastrointestinal_tract_polyps1.77825892
34MP0001819_abnormal_immune_cell1.75550229
35MP0002420_abnormal_adaptive_immunity1.75073746
36MP0002398_abnormal_bone_marrow1.73736677
37MP0003183_abnormal_peptide_metabolism1.72536801
38MP0001873_stomach_inflammation1.69592800
39MP0003763_abnormal_thymus_physiology1.68189064
40MP0003950_abnormal_plasma_membrane1.67710345
41MP0010155_abnormal_intestine_physiology1.67610110
42MP0004381_abnormal_hair_follicle1.67555209
43MP0010307_abnormal_tumor_latency1.64748001
44MP0009785_altered_susceptibility_to1.61981216
45MP0005409_darkened_coat_color1.60857918
46MP0010094_abnormal_chromosome_stability1.59492283
47MP0005397_hematopoietic_system_phenotyp1.58323434
48MP0001545_abnormal_hematopoietic_system1.58323434
49MP0000371_diluted_coat_color1.56280380
50MP0003252_abnormal_bile_duct1.55698274
51MP0000716_abnormal_immune_system1.50733543
52MP0002009_preneoplasia1.48000722
53MP0003172_abnormal_lysosome_physiology1.46749578
54MP0002254_reproductive_system_inflammat1.45922816
55MP0005410_abnormal_fertilization1.43620449
56MP0003656_abnormal_erythrocyte_physiolo1.40576257
57MP0002148_abnormal_hypersensitivity_rea1.39297728
58MP0002405_respiratory_system_inflammati1.37861178
59MP0004264_abnormal_extraembryonic_tissu1.37286225
60MP0002928_abnormal_bile_duct1.36224806
61MP0008961_abnormal_basal_metabolism1.30593953
62MP0005058_abnormal_lysosome_morphology1.27461538
63MP0003077_abnormal_cell_cycle1.27280748
64MP0004130_abnormal_muscle_cell1.27240173
65MP0001845_abnormal_inflammatory_respons1.26740956
66MP0000703_abnormal_thymus_morphology1.25793067
67MP0003868_abnormal_feces_composition1.24557792
68MP0000372_irregular_coat_pigmentation1.24121216
69MP0008058_abnormal_DNA_repair1.20479377
70MP0002722_abnormal_immune_system1.19952238
71MP0005408_hypopigmentation1.19826962
72MP0002429_abnormal_blood_cell1.19509300
73MP0001661_extended_life_span1.19195039
74MP0000689_abnormal_spleen_morphology1.18453802
75MP0002138_abnormal_hepatobiliary_system1.17588965
76MP0003091_abnormal_cell_migration1.16388800
77MP0002877_abnormal_melanocyte_morpholog1.14115687
78MP0005310_abnormal_salivary_gland1.13874817
79MP0003705_abnormal_hypodermis_morpholog1.10693181
80MP0004134_abnormal_chest_morphology1.10421819
81MP0001533_abnormal_skeleton_physiology1.08670007
82MP0006082_CNS_inflammation1.08327440
83MP0003566_abnormal_cell_adhesion1.08260030
84MP0009697_abnormal_copulation1.08228396
85MP0002998_abnormal_bone_remodeling1.07977558
86MP0005187_abnormal_penis_morphology1.05124572
87MP0005379_endocrine/exocrine_gland_phen1.04784838
88MP0003121_genomic_imprinting1.03271649
89MP0001853_heart_inflammation1.02937446
90MP0003866_abnormal_defecation1.02173005
91MP0003724_increased_susceptibility_to1.01257412
92MP0009703_decreased_birth_body1.01111523
93MP0004036_abnormal_muscle_relaxation0.96963232
94MP0005666_abnormal_adipose_tissue0.96702896
95MP0005220_abnormal_exocrine_pancreas0.95937351
96MP0004185_abnormal_adipocyte_glucose0.95472338
97MP0000733_abnormal_muscle_development0.94790370
98MP0010234_abnormal_vibrissa_follicle0.94755550
99MP0002088_abnormal_embryonic_growth/wei0.93712809
100MP0003191_abnormal_cellular_cholesterol0.93597252
101MP0003984_embryonic_growth_retardation0.92409448
102MP0005670_abnormal_white_adipose0.92308187
103MP0000015_abnormal_ear_pigmentation0.91660852
104MP0008469_abnormal_protein_level0.90983568
105MP0003448_altered_tumor_morphology0.90880322
106MP0005266_abnormal_metabolism0.89699202
107MP0001851_eye_inflammation0.89124333
108MP0005375_adipose_tissue_phenotype0.86986789
109MP0003787_abnormal_imprinting0.85874534
110MP0000003_abnormal_adipose_tissue0.85278289
111MP0006054_spinal_hemorrhage0.85201333
112MP0009764_decreased_sensitivity_to0.84384695
113MP0004484_altered_response_of0.83953016
114MP0000428_abnormal_craniofacial_morphol0.82931213
115MP0009115_abnormal_fat_cell0.82891130
116MP0000013_abnormal_adipose_tissue0.82843235
117MP0002086_abnormal_extraembryonic_tissu0.82712504
118MP0001929_abnormal_gametogenesis0.82574213
119MP0003828_pulmonary_edema0.81845127
120MP0010630_abnormal_cardiac_muscle0.77671543
121MP0008057_abnormal_DNA_replication0.77461694
122MP0002971_abnormal_brown_adipose0.75720757
123MP0003111_abnormal_nucleus_morphology0.75679051
124MP0004084_abnormal_cardiac_muscle0.75495034
125MP0005360_urolithiasis0.74720296
126MP0000609_abnormal_liver_physiology0.74621898
127MP0003221_abnormal_cardiomyocyte_apopto0.74400224
128MP0000465_gastrointestinal_hemorrhage0.73410511
129MP0001697_abnormal_embryo_size0.73130728
130MP0009763_increased_sensitivity_to0.72717262
131MP0002084_abnormal_developmental_patter0.72643125
132MP0000377_abnormal_hair_follicle0.71475505
133MP0003943_abnormal_hepatobiliary_system0.71214666
134MP0002075_abnormal_coat/hair_pigmentati0.70618116
135MP0005380_embryogenesis_phenotype0.69353808
136MP0001672_abnormal_embryogenesis/_devel0.69353808
137MP0002837_dystrophic_cardiac_calcinosis0.69183249
138MP0005171_absent_coat_pigmentation0.69166154
139MP0000858_altered_metastatic_potential0.68304085
140MP0008007_abnormal_cellular_replicative0.66998717
141MP0000647_abnormal_sebaceous_gland0.66115042
142MP0001879_abnormal_lymphatic_vessel0.65856543
143MP0003698_abnormal_male_reproductive0.65694468
144MP0003935_abnormal_craniofacial_develop0.65387797
145MP0005334_abnormal_fat_pad0.64740283
146MP0002168_other_aberrant_phenotype0.63460201
147MP0002332_abnormal_exercise_endurance0.63231284
148MP0005248_abnormal_Harderian_gland0.63139480
149MP0005075_abnormal_melanosome_morpholog0.61867511
150MP0003937_abnormal_limbs/digits/tail_de0.61175672
151MP0002095_abnormal_skin_pigmentation0.60520130
152MP0001915_intracranial_hemorrhage0.59341577
153MP0001186_pigmentation_phenotype0.59220373
154MP0000516_abnormal_urinary_system0.58884795
155MP0005367_renal/urinary_system_phenotyp0.58884795
156MP0001191_abnormal_skin_condition0.58844645
157MP0005621_abnormal_cell_physiology0.58833808
158MP0002210_abnormal_sex_determination0.58095807
159MP0004145_abnormal_muscle_electrophysio0.58073698
160MP0002163_abnormal_gland_morphology0.56958817
161MP0004197_abnormal_fetal_growth/weight/0.56579710

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.11737277
2Absent frontal sinuses (HP:0002688)3.62343325
3Thyroid carcinoma (HP:0002890)3.41285380
4Recurrent viral infections (HP:0004429)3.38173127
5Chromsome breakage (HP:0040012)3.31407690
6Recurrent bacterial skin infections (HP:0005406)3.19366239
7Autoimmune thrombocytopenia (HP:0001973)3.16975810
8Nasal polyposis (HP:0100582)3.11535841
9Recurrent fungal infections (HP:0002841)3.10072498
10Fair hair (HP:0002286)3.02762442
11Periodontitis (HP:0000704)3.02702922
12Sandal gap (HP:0001852)3.02574782
13Recurrent abscess formation (HP:0002722)2.91575739
14Rhabdomyosarcoma (HP:0002859)2.88554304
15Eczematoid dermatitis (HP:0000976)2.85375564
16Abnormality of chromosome stability (HP:0003220)2.84426263
17Chromosomal breakage induced by crosslinking agents (HP:0003221)2.83577791
18Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.83151103
19Macroorchidism (HP:0000053)2.77804605
20Frequent falls (HP:0002359)2.75217337
21Hepatoblastoma (HP:0002884)2.73551876
22Volvulus (HP:0002580)2.72112616
23Hyperventilation (HP:0002883)2.69965175
24Medulloblastoma (HP:0002885)2.69147540
25Short chin (HP:0000331)2.68709649
26Recurrent bronchitis (HP:0002837)2.68228814
27Curly hair (HP:0002212)2.64792035
28Abnormality of the ischium (HP:0003174)2.61159669
29Cystic hygroma (HP:0000476)2.60114566
30Deep philtrum (HP:0002002)2.55249008
31Colitis (HP:0002583)2.54480045
32Cerebral aneurysm (HP:0004944)2.52813549
33Abnormality of the nasal mucosa (HP:0000433)2.52585966
34Protruding tongue (HP:0010808)2.50226176
35Abnormal pancreas size (HP:0012094)2.49948402
36Long clavicles (HP:0000890)2.49798071
37Generalized hypopigmentation of hair (HP:0011358)2.49317121
38Blue irides (HP:0000635)2.47856230
39Hematochezia (HP:0002573)2.47598659
40Subaortic stenosis (HP:0001682)2.46005574
41Abnormality of the left ventricular outflow tract (HP:0011103)2.46005574
42Low anterior hairline (HP:0000294)2.45743619
43Nephroblastoma (Wilms tumor) (HP:0002667)2.44730429
44Recurrent gram-negative bacterial infections (HP:0005420)2.44546534
45Arterial thrombosis (HP:0004420)2.44256932
46Thyroiditis (HP:0100646)2.42258443
47Submucous cleft hard palate (HP:0000176)2.39634792
48Myositis (HP:0100614)2.38832225
49Inflammation of the large intestine (HP:0002037)2.38815612
50Widely spaced teeth (HP:0000687)2.38791954
51Abnormality of the frontal sinuses (HP:0002687)2.37673113
52Tubulointerstitial nephritis (HP:0001970)2.36679487
53Acute myeloid leukemia (HP:0004808)2.35111889
54Gaze-evoked nystagmus (HP:0000640)2.33759965
55Neoplasm of the adrenal cortex (HP:0100641)2.32276800
56Neonatal hypoglycemia (HP:0001998)2.31160144
57Neoplasm of striated muscle (HP:0009728)2.31064556
58Gingival bleeding (HP:0000225)2.29767131
59Hyperkalemia (HP:0002153)2.29456503
60Embryonal renal neoplasm (HP:0011794)2.29214449
61Spondylolisthesis (HP:0003302)2.27865532
62Difficulty running (HP:0009046)2.27529189
63Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.27040068
64Long eyelashes (HP:0000527)2.27020292
65T lymphocytopenia (HP:0005403)2.26446166
66Optic neuritis (HP:0100653)2.25778120
67Retrobulbar optic neuritis (HP:0100654)2.25778120
68Narrow palate (HP:0000189)2.25499026
69Abnormality of T cell number (HP:0011839)2.25180963
70Gastrointestinal inflammation (HP:0004386)2.23954739
71Syringomyelia (HP:0003396)2.23400150
72Spinal cord lesions (HP:0100561)2.23400150
73Gingivitis (HP:0000230)2.22631020
74Recurrent cutaneous fungal infections (HP:0011370)2.22548928
75Chronic mucocutaneous candidiasis (HP:0002728)2.22548928
76Hypoplastic ischia (HP:0003175)2.20188143
77Dynein arm defect of respiratory motile cilia (HP:0012255)2.20146464
78Absent/shortened dynein arms (HP:0200106)2.20146464
79Abnormal hair whorl (HP:0010721)2.19592696
80Hypoplastic iliac wings (HP:0002866)2.18261539
81Truncal obesity (HP:0001956)2.18020059
82Hip dysplasia (HP:0001385)2.17722112
83Cellulitis (HP:0100658)2.17106952
84Acanthocytosis (HP:0001927)2.16114504
85Conjunctival telangiectasia (HP:0000524)2.15636277
86Chronic diarrhea (HP:0002028)2.14261083
87Orchitis (HP:0100796)2.13994976
88Recurrent skin infections (HP:0001581)2.13484343
89Vasculitis (HP:0002633)2.12927953
90Hypoplastic labia majora (HP:0000059)2.12548803
91Neoplasm of the small intestine (HP:0100833)2.10901969
92Urethral obstruction (HP:0000796)2.10869617
93Transitional cell carcinoma of the bladder (HP:0006740)2.10109335
94Dysmetric saccades (HP:0000641)2.09904134
95Bladder neoplasm (HP:0009725)2.09849864
96Bladder carcinoma (HP:0002862)2.09849864
97Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.08169268
98Overgrowth (HP:0001548)2.08078502
99Heterotopia (HP:0002282)2.07960475
100Abnormality of the astrocytes (HP:0100707)2.07720429
101Astrocytoma (HP:0009592)2.07720429
102Myocardial infarction (HP:0001658)2.07706033
103Osteolytic defects of the phalanges of the hand (HP:0009771)2.07362535
104Osteolytic defects of the hand bones (HP:0009699)2.07362535
105Subacute progressive viral hepatitis (HP:0006572)2.06613833
106Abnormal delayed hypersensitivity skin test (HP:0002963)2.06055041
107Acute lymphatic leukemia (HP:0006721)2.04978058
108Fatigue (HP:0012378)2.04525399
109Biliary tract neoplasm (HP:0100574)2.04206427
110Abnormality of the labia majora (HP:0012881)2.02183584
111Menstrual irregularities (HP:0000858)2.01503313
112Mediastinal lymphadenopathy (HP:0100721)1.99572842
113Chronic hepatic failure (HP:0100626)1.98400532
114Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.93727313
115Disinhibition (HP:0000734)1.92405154
116Hypoplasia of the thymus (HP:0000778)1.91939167
117Abnormality of the vasculature of the conjunctiva (HP:0008054)1.91352814
118Glioma (HP:0009733)1.90734073
119Eosinophilia (HP:0001880)1.89744962
120Osteomyelitis (HP:0002754)1.89366149
121Pulmonary infiltrates (HP:0002113)1.88490083
122Aortic aneurysm (HP:0004942)1.87526009
123Bronchitis (HP:0012387)1.87289460
124Prominent nose (HP:0000448)1.85332517
125Pigmentary retinal degeneration (HP:0001146)1.84349736
126Recurrent sinusitis (HP:0011108)1.83669614
127Cafe-au-lait spot (HP:0000957)1.81643231
128Hyperacusis (HP:0010780)1.81113437
129Overlapping toe (HP:0001845)1.80905627
130Oligodactyly (hands) (HP:0001180)1.80436243
131Cubitus valgus (HP:0002967)1.80171624
132Vertebral arch anomaly (HP:0008438)1.79791676
133Neoplasm of the oral cavity (HP:0100649)1.79020093
134Abnormality of chromosome segregation (HP:0002916)1.78625721
135Gastrointestinal carcinoma (HP:0002672)1.77001071
136Malignant gastrointestinal tract tumors (HP:0006749)1.77001071
137Prostate neoplasm (HP:0100787)1.76943391
138Premature loss of primary teeth (HP:0006323)1.75940528
139Aqueductal stenosis (HP:0002410)1.75874524
140Neoplasm of the thyroid gland (HP:0100031)1.75410751
141Thick nail (HP:0001805)1.75056927
142Tapered finger (HP:0001182)1.74661988
143Chest pain (HP:0100749)1.74601759
144Neoplasm of the tracheobronchial system (HP:0100552)1.74594895
145Agammaglobulinemia (HP:0004432)1.74249636
146Degeneration of the lateral corticospinal tracts (HP:0002314)1.72943961
147Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.72943961
148Drooling (HP:0002307)1.72817556
149Elfin facies (HP:0004428)1.71409263
150IgA deficiency (HP:0002720)1.70970865
151Clubbing of toes (HP:0100760)1.70867284
152Leukocytosis (HP:0001974)1.70653928
153Febrile seizures (HP:0002373)1.70511042
154Genetic anticipation (HP:0003743)1.70446134
155Abnormal biliary tract morphology (HP:0012440)1.69770628
156Hamartoma (HP:0010566)1.69757160
157Large earlobe (HP:0009748)1.69738722
158B lymphocytopenia (HP:0010976)1.69278776
159Abnormality of B cell number (HP:0010975)1.69278776
160Lip pit (HP:0100267)1.66573879
161Thick eyebrow (HP:0000574)1.66065096
162Papillary thyroid carcinoma (HP:0002895)1.65624915
163Mitral stenosis (HP:0001718)1.63166179
164Abnormality of T cells (HP:0002843)1.62371713
165Meningitis (HP:0001287)1.61903431
166Viral hepatitis (HP:0006562)1.61332027
167Spontaneous hematomas (HP:0007420)1.61314896
168Obsessive-compulsive behavior (HP:0000722)1.60748509
169Lymphopenia (HP:0001888)1.60304528
170Coarse hair (HP:0002208)1.60290432
171Increased IgE level (HP:0003212)1.59718398
172Cutis marmorata (HP:0000965)1.59184994
173Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.58704263
174Abnormality of cells of the lymphoid lineage (HP:0012140)1.57267095
175Panhypogammaglobulinemia (HP:0003139)1.57173388
176Bronchiectasis (HP:0002110)1.56841586

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.38568779
2AKT33.23850520
3ACVR1B2.68735424
4MAP4K12.62098932
5CAMK1D2.45142832
6CAMK1G2.44075107
7TYK22.38872282
8RIPK12.36749620
9MAP3K142.28007141
10IKBKE2.24748069
11JAK12.24553181
12NLK2.23566674
13MAP3K102.12095802
14JAK32.09202812
15TAOK32.07927036
16FGFR31.91413429
17PNCK1.86773168
18STK38L1.82148182
19BMPR1B1.80322581
20OBSCN1.78952471
21CASK1.65877604
22TBK11.65569112
23PTK61.62434556
24FRK1.57821525
25TXK1.54221512
26PIK3CG1.50988773
27TNIK1.50174996
28INSRR1.45361077
29TTN1.44062427
30RIPK41.41932907
31IKBKB1.41166867
32NUAK11.38344328
33MAP3K131.37953947
34DMPK1.37318489
35EIF2AK31.35845543
36STK31.35500396
37FGFR41.34786053
38YES11.34679839
39CHUK1.34201368
40SGK31.30887403
41IRAK41.29749418
42SIK11.29637092
43MAP3K41.29121715
44KIT1.22165473
45EEF2K1.19943740
46BRD41.18060467
47ZAP701.17530698
48SIK21.17298418
49CSK1.16301900
50ERN11.14240621
51CSF1R1.13047399
52ITK1.12011197
53CDK61.11514372
54TGFBR21.11352487
55PDGFRB1.11255852
56HCK1.10994394
57MKNK21.08006251
58LATS11.05442306
59NEK61.02345665
60STK101.01790257
61JAK20.99371747
62TRIB30.97193502
63PKN20.96354960
64SGK20.95059891
65CDK90.94713506
66WNK10.94463314
67ERBB30.94179734
68MTOR0.93836640
69STK40.92180156
70BRSK20.90315143
71KSR10.89177354
72SGK4940.88426983
73SGK2230.88426983
74SYK0.88115150
75BTK0.86541658
76EPHB10.86355298
77PRKAA20.86162539
78TRPM70.84810977
79PLK40.84683122
80HIPK20.81854585
81RPS6KA40.80404325
82LCK0.79881202
83STK390.79493051
84NEK90.76979091
85MAP3K70.76852786
86TEC0.75143535
87BMPR20.75042662
88PIK3CA0.74697406
89NTRK30.73969081
90BLK0.73309631
91RET0.72742253
92PDK10.71461123
93IRAK10.70628704
94STK110.69939515
95NEK20.69661455
96PIM10.69407066
97ICK0.67113886
98RPS6KB10.66708639
99CDC70.65387217
100RPS6KB20.64135312
101FGFR20.63268553
102PRKAA10.61715051
103MARK30.60887531
104PRKCH0.60471737
105CAMKK20.60345303
106CHEK10.60129679
107PDK30.59179001
108PDK40.59179001
109MAP2K30.59165132
110PLK20.58400934
111MAP3K20.58028468
112FLT30.57516560
113CDK30.55684741
114EPHA30.55007634
115RAF10.54930033
116PDGFRA0.54248149
117PRKCQ0.53302995
118EGFR0.52012345
119STK240.51944675
120SGK10.51734339
121ATR0.51677963
122MAP3K60.51192934
123GRK60.50484586
124MAPK100.50353199
125PTK2B0.48329726
126SCYL20.48203060
127OXSR10.47018831
128CAMK40.46636980
129FES0.45848229
130IRAK30.45672545
131CDK40.44108997
132MAPK110.43993133
133MAP3K50.43845627
134ATM0.43749908
135MARK20.42676487
136BMX0.41830947
137MAP2K40.41325926
138MELK0.41076137
139PRKACB0.40446039
140PAK30.39192293
141FER0.37429464
142FGR0.37031617
143GSK3B0.36520024
144DYRK1A0.36059942
145MAPK70.35863287
146PRKG10.34902148

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034502.39934871
2Osteoclast differentiation_Homo sapiens_hsa043802.09224500
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.04893282
4B cell receptor signaling pathway_Homo sapiens_hsa046621.96174326
5Toll-like receptor signaling pathway_Homo sapiens_hsa046201.90775689
6Leishmaniasis_Homo sapiens_hsa051401.88802161
7Circadian rhythm_Homo sapiens_hsa047101.80566303
8Measles_Homo sapiens_hsa051621.76775813
9Lysine degradation_Homo sapiens_hsa003101.66362048
10Carbohydrate digestion and absorption_Homo sapiens_hsa049731.66091364
11Type II diabetes mellitus_Homo sapiens_hsa049301.60823261
12Toxoplasmosis_Homo sapiens_hsa051451.60377010
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.59440361
14TNF signaling pathway_Homo sapiens_hsa046681.57541329
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.56227823
16Influenza A_Homo sapiens_hsa051641.47446278
17T cell receptor signaling pathway_Homo sapiens_hsa046601.46992077
18Fanconi anemia pathway_Homo sapiens_hsa034601.41675960
19Chronic myeloid leukemia_Homo sapiens_hsa052201.41551759
20Primary immunodeficiency_Homo sapiens_hsa053401.40184153
21Renal cell carcinoma_Homo sapiens_hsa052111.39581273
22Dorso-ventral axis formation_Homo sapiens_hsa043201.38572237
23Caffeine metabolism_Homo sapiens_hsa002321.34083197
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.30085101
25Insulin resistance_Homo sapiens_hsa049311.26504350
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.26490795
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.26272244
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.24090603
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.23057561
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.21820262
31Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20106077
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.18872585
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.17924405
34ErbB signaling pathway_Homo sapiens_hsa040121.17474656
35ABC transporters_Homo sapiens_hsa020101.16772592
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.15631901
37Herpes simplex infection_Homo sapiens_hsa051681.15210334
38Chemokine signaling pathway_Homo sapiens_hsa040621.15207215
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.15079588
40Acute myeloid leukemia_Homo sapiens_hsa052211.14956575
41Antigen processing and presentation_Homo sapiens_hsa046121.13971939
42Hepatitis B_Homo sapiens_hsa051611.13884806
43Small cell lung cancer_Homo sapiens_hsa052221.13098415
44Pancreatic cancer_Homo sapiens_hsa052121.11665004
45Tuberculosis_Homo sapiens_hsa051521.09748981
46Systemic lupus erythematosus_Homo sapiens_hsa053221.09707004
47mTOR signaling pathway_Homo sapiens_hsa041501.09694762
48Long-term potentiation_Homo sapiens_hsa047201.07958626
49Platelet activation_Homo sapiens_hsa046111.05704711
50Thyroid hormone signaling pathway_Homo sapiens_hsa049191.04797479
51Cell cycle_Homo sapiens_hsa041101.04728931
52Homologous recombination_Homo sapiens_hsa034401.03615913
53Apoptosis_Homo sapiens_hsa042101.02832762
54Inositol phosphate metabolism_Homo sapiens_hsa005621.02301507
55Prolactin signaling pathway_Homo sapiens_hsa049171.01834137
56Hepatitis C_Homo sapiens_hsa051601.00373360
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98994953
58Viral myocarditis_Homo sapiens_hsa054160.98511828
59Staphylococcus aureus infection_Homo sapiens_hsa051500.97516746
60Hematopoietic cell lineage_Homo sapiens_hsa046400.96827808
61Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.96092160
62Long-term depression_Homo sapiens_hsa047300.95987476
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95571941
64Non-small cell lung cancer_Homo sapiens_hsa052230.94862530
65Thyroid cancer_Homo sapiens_hsa052160.93429443
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.93425310
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.93237263
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.92868990
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.91660632
70Legionellosis_Homo sapiens_hsa051340.90821211
71Pertussis_Homo sapiens_hsa051330.88359118
72Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85472043
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.83039839
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.82759219
75TGF-beta signaling pathway_Homo sapiens_hsa043500.82027628
76mRNA surveillance pathway_Homo sapiens_hsa030150.80415224
77Alcoholism_Homo sapiens_hsa050340.79889456
78GnRH signaling pathway_Homo sapiens_hsa049120.79800613
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78127058
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.77616819
81Malaria_Homo sapiens_hsa051440.76182025
82Amoebiasis_Homo sapiens_hsa051460.75398857
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74754629
84Sphingolipid metabolism_Homo sapiens_hsa006000.74684640
85Nitrogen metabolism_Homo sapiens_hsa009100.74595739
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74544439
87Oocyte meiosis_Homo sapiens_hsa041140.73961308
88Proteoglycans in cancer_Homo sapiens_hsa052050.73567170
89MicroRNAs in cancer_Homo sapiens_hsa052060.73428017
90Basal transcription factors_Homo sapiens_hsa030220.72746471
91Viral carcinogenesis_Homo sapiens_hsa052030.71261553
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.71203159
93Renin-angiotensin system_Homo sapiens_hsa046140.70937948
94Graft-versus-host disease_Homo sapiens_hsa053320.70909167
95Prostate cancer_Homo sapiens_hsa052150.70271087
96Salmonella infection_Homo sapiens_hsa051320.69909370
97FoxO signaling pathway_Homo sapiens_hsa040680.69598988
98Glioma_Homo sapiens_hsa052140.69002350
99Endometrial cancer_Homo sapiens_hsa052130.68420421
100Melanoma_Homo sapiens_hsa052180.66961053
101AMPK signaling pathway_Homo sapiens_hsa041520.66624157
102Vascular smooth muscle contraction_Homo sapiens_hsa042700.66406965
103Allograft rejection_Homo sapiens_hsa053300.66096130
104Focal adhesion_Homo sapiens_hsa045100.65616008
105Glucagon signaling pathway_Homo sapiens_hsa049220.65421386
106Adherens junction_Homo sapiens_hsa045200.64834486
107Glycosaminoglycan degradation_Homo sapiens_hsa005310.64203670
108Notch signaling pathway_Homo sapiens_hsa043300.62831321
109Fatty acid biosynthesis_Homo sapiens_hsa000610.60056084
110VEGF signaling pathway_Homo sapiens_hsa043700.59771278
111African trypanosomiasis_Homo sapiens_hsa051430.59298466
112Estrogen signaling pathway_Homo sapiens_hsa049150.58760880
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58166170
114Oxytocin signaling pathway_Homo sapiens_hsa049210.57355061
115Insulin signaling pathway_Homo sapiens_hsa049100.56955211
116HTLV-I infection_Homo sapiens_hsa051660.54138750
117Pancreatic secretion_Homo sapiens_hsa049720.53918625
118cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53463036
119cAMP signaling pathway_Homo sapiens_hsa040240.52164064
120Taste transduction_Homo sapiens_hsa047420.51450870
121RNA transport_Homo sapiens_hsa030130.51103615
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.49927715
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.49738657
124MAPK signaling pathway_Homo sapiens_hsa040100.48823324
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48715100
126Shigellosis_Homo sapiens_hsa051310.48230071
127Choline metabolism in cancer_Homo sapiens_hsa052310.48158345
128HIF-1 signaling pathway_Homo sapiens_hsa040660.48144892
129Renin secretion_Homo sapiens_hsa049240.47718841
130Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47553157
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.47499559
132PPAR signaling pathway_Homo sapiens_hsa033200.42786031
133Colorectal cancer_Homo sapiens_hsa052100.42586502

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »