

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | protein localization to kinetochore (GO:0034501) | 5.79442515 |
| 2 | mitotic metaphase plate congression (GO:0007080) | 5.39330984 |
| 3 | mitotic chromosome condensation (GO:0007076) | 5.19292574 |
| 4 | mitotic sister chromatid segregation (GO:0000070) | 5.18971621 |
| 5 | protein localization to chromosome, centromeric region (GO:0071459) | 5.01927404 |
| 6 | sister chromatid segregation (GO:0000819) | 4.97044922 |
| 7 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 4.85639700 |
| 8 | kinetochore organization (GO:0051383) | 4.83484860 |
| 9 | nuclear pore organization (GO:0006999) | 4.80528886 |
| 10 | DNA unwinding involved in DNA replication (GO:0006268) | 4.80409936 |
| 11 | nuclear pore complex assembly (GO:0051292) | 4.77273346 |
| 12 | meiotic chromosome segregation (GO:0045132) | 4.77006333 |
| 13 | metaphase plate congression (GO:0051310) | 4.75858581 |
| 14 | attachment of spindle microtubules to kinetochore (GO:0008608) | 4.64671133 |
| 15 | chromatin remodeling at centromere (GO:0031055) | 4.55077583 |
| 16 | establishment of chromosome localization (GO:0051303) | 4.52100914 |
| 17 | mitotic nuclear envelope disassembly (GO:0007077) | 4.46725565 |
| 18 | CENP-A containing nucleosome assembly (GO:0034080) | 4.46074198 |
| 19 | DNA replication-dependent nucleosome assembly (GO:0006335) | 4.35247875 |
| 20 | DNA replication-dependent nucleosome organization (GO:0034723) | 4.35247875 |
| 21 | DNA replication initiation (GO:0006270) | 4.30816227 |
| 22 | establishment of integrated proviral latency (GO:0075713) | 4.29618745 |
| 23 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.29313044 |
| 24 | regulation of spindle organization (GO:0090224) | 4.23163736 |
| 25 | membrane disassembly (GO:0030397) | 4.17064628 |
| 26 | nuclear envelope disassembly (GO:0051081) | 4.17064628 |
| 27 | DNA replication-independent nucleosome assembly (GO:0006336) | 4.12757486 |
| 28 | DNA replication-independent nucleosome organization (GO:0034724) | 4.12757486 |
| 29 | DNA replication checkpoint (GO:0000076) | 4.12508717 |
| 30 | kinetochore assembly (GO:0051382) | 4.07377047 |
| 31 | DNA strand elongation (GO:0022616) | 4.05890163 |
| 32 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.94358977 |
| 33 | regulation of mitotic spindle organization (GO:0060236) | 3.91684791 |
| 34 | histone exchange (GO:0043486) | 3.90190060 |
| 35 | mitotic sister chromatid cohesion (GO:0007064) | 3.87358010 |
| 36 | regulation of chromosome segregation (GO:0051983) | 3.86734468 |
| 37 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.86713791 |
| 38 | spindle checkpoint (GO:0031577) | 3.84959018 |
| 39 | positive regulation of chromosome segregation (GO:0051984) | 3.84322575 |
| 40 | mitotic recombination (GO:0006312) | 3.82586808 |
| 41 | chromosome segregation (GO:0007059) | 3.79089861 |
| 42 | protein localization to chromosome (GO:0034502) | 3.77218447 |
| 43 | telomere maintenance via recombination (GO:0000722) | 3.74190299 |
| 44 | regulation of sister chromatid cohesion (GO:0007063) | 3.71403581 |
| 45 | ribosome assembly (GO:0042255) | 3.67507253 |
| 46 | positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101) | 3.66009005 |
| 47 | positive regulation of mitotic sister chromatid separation (GO:1901970) | 3.66009005 |
| 48 | positive regulation of mitotic metaphase/anaphase transition (GO:0045842) | 3.66009005 |
| 49 | negative regulation of chromosome segregation (GO:0051985) | 3.63550636 |
| 50 | pore complex assembly (GO:0046931) | 3.62533940 |
| 51 | spindle assembly checkpoint (GO:0071173) | 3.62434796 |
| 52 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 3.59279847 |
| 53 | chromatin assembly or disassembly (GO:0006333) | 3.59197971 |
| 54 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 3.57629934 |
| 55 | negative regulation of sister chromatid segregation (GO:0033046) | 3.57629934 |
| 56 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 3.57629934 |
| 57 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 3.57629934 |
| 58 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 3.54916444 |
| 59 | protein K6-linked ubiquitination (GO:0085020) | 3.54605112 |
| 60 | DNA duplex unwinding (GO:0032508) | 3.53663379 |
| 61 | DNA geometric change (GO:0032392) | 3.53416197 |
| 62 | mitotic spindle checkpoint (GO:0071174) | 3.53185022 |
| 63 | mitotic spindle assembly checkpoint (GO:0007094) | 3.52459196 |
| 64 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.52391538 |
| 65 | chromosome condensation (GO:0030261) | 3.52081366 |
| 66 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 3.52031705 |
| 67 | regulation of centrosome cycle (GO:0046605) | 3.51113092 |
| 68 | nucleobase-containing small molecule interconversion (GO:0015949) | 3.47278718 |
| 69 | regulation of mitotic sister chromatid separation (GO:0010965) | 3.44341183 |
| 70 | regulation of mitotic sister chromatid segregation (GO:0033047) | 3.44341183 |
| 71 | regulation of sister chromatid segregation (GO:0033045) | 3.44341183 |
| 72 | spindle assembly involved in mitosis (GO:0090307) | 3.39980430 |
| 73 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.38109363 |
| 74 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.38109363 |
| 75 | telomere maintenance via telomere lengthening (GO:0010833) | 3.37873936 |
| 76 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.36572549 |
| 77 | heterochromatin organization (GO:0070828) | 3.31179457 |
| 78 | regulation of histone H3-K9 methylation (GO:0051570) | 3.29891299 |
| 79 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.29102889 |
| 80 | establishment of viral latency (GO:0019043) | 3.28592275 |
| 81 | regulation of centriole replication (GO:0046599) | 3.27376529 |
| 82 | protein complex localization (GO:0031503) | 3.26600246 |
| 83 | nuclear envelope organization (GO:0006998) | 3.24669690 |
| 84 | DNA conformation change (GO:0071103) | 3.23885941 |
| 85 | regulation of telomere maintenance via telomerase (GO:0032210) | 3.22810359 |
| 86 | regulation of translational fidelity (GO:0006450) | 3.22461317 |
| 87 | DNA packaging (GO:0006323) | 3.21835659 |
| 88 | ATP-dependent chromatin remodeling (GO:0043044) | 3.21666666 |
| 89 | DNA ligation (GO:0006266) | 3.20089628 |
| 90 | * mitotic cytokinesis (GO:0000281) | 3.18326968 |
| 91 | regulation of DNA endoreduplication (GO:0032875) | 3.16230511 |
| 92 | microtubule depolymerization (GO:0007019) | 3.15499169 |
| 93 | microtubule cytoskeleton organization involved in mitosis (GO:1902850) | 3.15491985 |
| 94 | resolution of meiotic recombination intermediates (GO:0000712) | 3.14246925 |
| 95 | regulation of double-strand break repair via homologous recombination (GO:0010569) | 3.13680906 |
| 96 | cellular protein complex localization (GO:0034629) | 3.13041251 |
| 97 | non-recombinational repair (GO:0000726) | 3.12919359 |
| 98 | double-strand break repair via nonhomologous end joining (GO:0006303) | 3.12919359 |
| 99 | DNA topological change (GO:0006265) | 3.12514181 |
| 100 | regulation of helicase activity (GO:0051095) | 3.08641959 |
| 101 | deoxyribonucleotide biosynthetic process (GO:0009263) | 3.08067637 |
| 102 | IMP biosynthetic process (GO:0006188) | 3.07924020 |
| 103 | nucleobase biosynthetic process (GO:0046112) | 3.06818713 |
| 104 | negative regulation of histone methylation (GO:0031061) | 3.05892819 |
| 105 | mitotic spindle organization (GO:0007052) | 3.04672311 |
| 106 | negative regulation of DNA repair (GO:0045738) | 3.03190811 |
| 107 | regulation of RNA export from nucleus (GO:0046831) | 3.03045829 |
| 108 | regulation of translational termination (GO:0006449) | 3.02917783 |
| 109 | spindle organization (GO:0007051) | 3.02508458 |
| 110 | regulation of centrosome duplication (GO:0010824) | 3.00310746 |
| 111 | mismatch repair (GO:0006298) | 2.99919119 |
| 112 | formation of translation preinitiation complex (GO:0001731) | 2.99851717 |
| 113 | positive regulation of cytokinesis (GO:0032467) | 2.99094378 |
| 114 | chromatin assembly (GO:0031497) | 2.96989719 |
| 115 | mitotic cell cycle (GO:0000278) | 2.95258325 |
| 116 | chromosome organization (GO:0051276) | 2.94585795 |
| 117 | histone-serine phosphorylation (GO:0035404) | 2.92745363 |
| 118 | COPI coating of Golgi vesicle (GO:0048205) | 2.92130748 |
| 119 | Golgi transport vesicle coating (GO:0048200) | 2.92130748 |
| 120 | telomere maintenance (GO:0000723) | 2.90455540 |
| 121 | spliceosomal tri-snRNP complex assembly (GO:0000244) | 2.90347046 |
| 122 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 2.90077425 |
| 123 | histone phosphorylation (GO:0016572) | 2.90057050 |
| 124 | regulation of gene silencing by RNA (GO:0060966) | 2.87973705 |
| 125 | regulation of posttranscriptional gene silencing (GO:0060147) | 2.87973705 |
| 126 | regulation of gene silencing by miRNA (GO:0060964) | 2.87973705 |
| 127 | telomere organization (GO:0032200) | 2.87812412 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | * FOXM1_23109430_ChIP-Seq_U2OS_Human | 6.78662140 |
| 2 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 4.58257485 |
| 3 | * FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 4.10320702 |
| 4 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.63681260 |
| 5 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.81227306 |
| 6 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.79166412 |
| 7 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.70438706 |
| 8 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.68788968 |
| 9 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.59433194 |
| 10 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.49975653 |
| 11 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 2.39572165 |
| 12 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 2.33688743 |
| 13 | * NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.27237409 |
| 14 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.23987576 |
| 15 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 2.21744244 |
| 16 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.16968808 |
| 17 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.07642396 |
| 18 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.01723473 |
| 19 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 2.00403815 |
| 20 | E2F7_22180533_ChIP-Seq_HELA_Human | 10.3489765 |
| 21 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.98882209 |
| 22 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.95742844 |
| 23 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 1.86403252 |
| 24 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.85483138 |
| 25 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.85155843 |
| 26 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.80432770 |
| 27 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.79467980 |
| 28 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 1.75231704 |
| 29 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.73873638 |
| 30 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.71928744 |
| 31 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.69459328 |
| 32 | MYC_22102868_ChIP-Seq_BL_Human | 1.67825291 |
| 33 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.67708214 |
| 34 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.67322552 |
| 35 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.67088893 |
| 36 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.61775365 |
| 37 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.60807794 |
| 38 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.58670360 |
| 39 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.55198636 |
| 40 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.54841054 |
| 41 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.50643359 |
| 42 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.49171002 |
| 43 | * TTF2_22483619_ChIP-Seq_HELA_Human | 1.45136023 |
| 44 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.42957331 |
| 45 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.39741022 |
| 46 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.38276474 |
| 47 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.37958663 |
| 48 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.36563419 |
| 49 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.36361370 |
| 50 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.35461668 |
| 51 | * GABP_19822575_ChIP-Seq_HepG2_Human | 1.33060330 |
| 52 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.31475560 |
| 53 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.29209383 |
| 54 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.28865783 |
| 55 | * KDM5A_27292631_Chip-Seq_BREAST_Human | 1.27232789 |
| 56 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.27090160 |
| 57 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.26899981 |
| 58 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.26034723 |
| 59 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.24984631 |
| 60 | * ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.22434427 |
| 61 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.22314061 |
| 62 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.22314061 |
| 63 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.22314061 |
| 64 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.18162999 |
| 65 | * E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.15849749 |
| 66 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.14787362 |
| 67 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.13829326 |
| 68 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 1.13298818 |
| 69 | * FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.13052193 |
| 70 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.12901117 |
| 71 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.12266963 |
| 72 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.11768366 |
| 73 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.11472152 |
| 74 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 1.11348122 |
| 75 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.10807130 |
| 76 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.06534784 |
| 77 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.05923334 |
| 78 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 1.05758507 |
| 79 | SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 1.05758507 |
| 80 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 1.05726934 |
| 81 | CHD1_26751641_Chip-Seq_LNCaP_Human | 1.04398073 |
| 82 | ATF3_27146783_Chip-Seq_COLON_Human | 1.04090064 |
| 83 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.03811192 |
| 84 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 1.03376055 |
| 85 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.02828256 |
| 86 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.01274385 |
| 87 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.01138271 |
| 88 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.00177035 |
| 89 | TCF3_18692474_ChIP-Seq_MESCs_Mouse | 0.98921781 |
| 90 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 0.97515737 |
| 91 | NKX2-5_21415370_ChIP-Seq_HL-1_Mouse | 0.97021848 |
| 92 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 0.96961540 |
| 93 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.96697247 |
| 94 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.96300335 |
| 95 | CLOCK_20551151_ChIP-Seq_293T_Human | 0.96172449 |
| 96 | EOMES_20176728_ChIP-ChIP_TSCs_Mouse | 0.95107420 |
| 97 | * NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 0.94290388 |
| 98 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 0.94199871 |
| 99 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 0.93725669 |
| 100 | VDR_21846776_ChIP-Seq_THP-1_Human | 0.93376866 |
| 101 | TRIM28_19339689_ChIP-ChIP_MESCs_Mouse | 0.93281370 |
| 102 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 0.93079257 |
| 103 | * TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 0.92566621 |
| 104 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 0.91913788 |
| 105 | * CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.91277492 |
| 106 | * ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.89156414 |
| 107 | * KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.88139906 |
| 108 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 0.87232113 |
| 109 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.86577700 |
| 110 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.85661509 |
| 111 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 0.84472383 |
| 112 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.84151549 |
| 113 | P300_27058665_Chip-Seq_ZR-75-30cells_Human | 0.82391782 |
| 114 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.82263961 |
| 115 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.81017994 |
| 116 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.80439167 |
| 117 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 0.80414877 |
| 118 | * CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.80259981 |
| 119 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.78860027 |
| 120 | SOX2_18358816_ChIP-ChIP_MESCs_Mouse | 0.77435813 |
| 121 | BRD4_25478319_ChIP-Seq_HGPS_Human | 0.77258984 |
| 122 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.77179527 |
| 123 | * UBF1/2_26484160_Chip-Seq_HMECs_Human | 0.76943389 |
| 124 | NANOG_18347094_ChIP-ChIP_MESCs_Mouse | 0.75395691 |
| 125 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.75044828 |
| 126 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 0.73540651 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.17786798 |
| 2 | MP0010094_abnormal_chromosome_stability | 4.80024297 |
| 3 | MP0003111_abnormal_nucleus_morphology | 4.66517524 |
| 4 | MP0004957_abnormal_blastocyst_morpholog | 4.19152160 |
| 5 | MP0003077_abnormal_cell_cycle | 4.11608876 |
| 6 | MP0008057_abnormal_DNA_replication | 4.10578805 |
| 7 | MP0008058_abnormal_DNA_repair | 2.89628508 |
| 8 | MP0008007_abnormal_cellular_replicative | 2.72400036 |
| 9 | MP0008932_abnormal_embryonic_tissue | 2.62905650 |
| 10 | MP0003123_paternal_imprinting | 2.56214049 |
| 11 | MP0010352_gastrointestinal_tract_polyps | 2.47622923 |
| 12 | MP0001730_embryonic_growth_arrest | 2.42801705 |
| 13 | MP0008877_abnormal_DNA_methylation | 2.42753820 |
| 14 | MP0010307_abnormal_tumor_latency | 2.41851771 |
| 15 | MP0000350_abnormal_cell_proliferation | 2.39273499 |
| 16 | MP0003950_abnormal_plasma_membrane | 2.18646129 |
| 17 | MP0004185_abnormal_adipocyte_glucose | 2.08096234 |
| 18 | MP0001672_abnormal_embryogenesis/_devel | 1.89279473 |
| 19 | MP0005380_embryogenesis_phenotype | 1.89279473 |
| 20 | MP0002396_abnormal_hematopoietic_system | 1.88710255 |
| 21 | MP0001697_abnormal_embryo_size | 1.87942670 |
| 22 | MP0009697_abnormal_copulation | 1.86925332 |
| 23 | MP0010030_abnormal_orbit_morphology | 1.83431484 |
| 24 | MP0005076_abnormal_cell_differentiation | 1.80841588 |
| 25 | MP0003786_premature_aging | 1.80678559 |
| 26 | MP0002085_abnormal_embryonic_tissue | 1.75066960 |
| 27 | MP0003705_abnormal_hypodermis_morpholog | 1.74789020 |
| 28 | MP0002084_abnormal_developmental_patter | 1.70532873 |
| 29 | MP0003984_embryonic_growth_retardation | 1.70180175 |
| 30 | MP0002088_abnormal_embryonic_growth/wei | 1.65933572 |
| 31 | MP0003121_genomic_imprinting | 1.63973672 |
| 32 | MP0002086_abnormal_extraembryonic_tissu | 1.61092560 |
| 33 | MP0002080_prenatal_lethality | 1.56819936 |
| 34 | MP0003718_maternal_effect | 1.56489253 |
| 35 | MP0004233_abnormal_muscle_weight | 1.56386926 |
| 36 | MP0000490_abnormal_crypts_of | 1.54150093 |
| 37 | MP0004197_abnormal_fetal_growth/weight/ | 1.53955844 |
| 38 | MP0002210_abnormal_sex_determination | 1.48484980 |
| 39 | MP0005501_abnormal_skin_physiology | 1.45139935 |
| 40 | MP0005257_abnormal_intraocular_pressure | 1.44017742 |
| 41 | MP0002019_abnormal_tumor_incidence | 1.43409996 |
| 42 | MP0004808_abnormal_hematopoietic_stem | 1.38971361 |
| 43 | MP0002796_impaired_skin_barrier | 1.38400195 |
| 44 | MP0000313_abnormal_cell_death | 1.37516525 |
| 45 | MP0003890_abnormal_embryonic-extraembry | 1.37262066 |
| 46 | MP0001929_abnormal_gametogenesis | 1.27921436 |
| 47 | MP0001145_abnormal_male_reproductive | 1.27444521 |
| 48 | MP0008438_abnormal_cutaneous_collagen | 1.23032178 |
| 49 | MP0002060_abnormal_skin_morphology | 1.22772912 |
| 50 | MP0001348_abnormal_lacrimal_gland | 1.21613391 |
| 51 | MP0003091_abnormal_cell_migration | 1.18229781 |
| 52 | MP0003566_abnormal_cell_adhesion | 1.18028732 |
| 53 | MP0001293_anophthalmia | 1.17727209 |
| 54 | MP0000762_abnormal_tongue_morphology | 1.17682242 |
| 55 | MP0004272_abnormal_basement_membrane | 1.13119300 |
| 56 | MP0000653_abnormal_sex_gland | 1.12352364 |
| 57 | MP0002653_abnormal_ependyma_morphology | 1.11313022 |
| 58 | MP0003567_abnormal_fetal_cardiomyocyte | 1.09623185 |
| 59 | MP0005023_abnormal_wound_healing | 1.03218539 |
| 60 | MP0003937_abnormal_limbs/digits/tail_de | 1.02048880 |
| 61 | MP0001346_abnormal_lacrimal_gland | 1.01974612 |
| 62 | MP0000566_synostosis | 1.01446950 |
| 63 | MP0002009_preneoplasia | 1.01058021 |
| 64 | MP0000703_abnormal_thymus_morphology | 0.98174547 |
| 65 | MP0001915_intracranial_hemorrhage | 0.97097940 |
| 66 | MP0001119_abnormal_female_reproductive | 0.95755498 |
| 67 | MP0000627_abnormal_mammary_gland | 0.95717229 |
| 68 | MP0009053_abnormal_anal_canal | 0.93498484 |
| 69 | MP0001216_abnormal_epidermal_layer | 0.90001253 |
| 70 | MP0001243_abnormal_dermal_layer | 0.89753885 |
| 71 | MP0001727_abnormal_embryo_implantation | 0.88518711 |
| 72 | MP0001661_extended_life_span | 0.87102331 |
| 73 | MP0001849_ear_inflammation | 0.86785689 |
| 74 | MP0002398_abnormal_bone_marrow | 0.86739810 |
| 75 | MP0010234_abnormal_vibrissa_follicle | 0.86078894 |
| 76 | MP0009278_abnormal_bone_marrow | 0.85614191 |
| 77 | MP0001545_abnormal_hematopoietic_system | 0.85293538 |
| 78 | MP0005397_hematopoietic_system_phenotyp | 0.85293538 |
| 79 | MP0003941_abnormal_skin_development | 0.84896288 |
| 80 | MP0005621_abnormal_cell_physiology | 0.84799027 |
| 81 | MP0002102_abnormal_ear_morphology | 0.84076276 |
| 82 | MP0003221_abnormal_cardiomyocyte_apopto | 0.83690836 |
| 83 | MP0002111_abnormal_tail_morphology | 0.82917255 |
| 84 | MP0003385_abnormal_body_wall | 0.82043770 |
| 85 | MP0000428_abnormal_craniofacial_morphol | 0.81963798 |
| 86 | MP0002269_muscular_atrophy | 0.81820867 |
| 87 | MP0001299_abnormal_eye_distance/ | 0.81593700 |
| 88 | MP0003119_abnormal_digestive_system | 0.81545469 |
| 89 | MP0005451_abnormal_body_composition | 0.81091090 |
| 90 | MP0001881_abnormal_mammary_gland | 0.80802489 |
| 91 | MP0005384_cellular_phenotype | 0.79987979 |
| 92 | MP0002722_abnormal_immune_system | 0.79868718 |
| 93 | MP0005408_hypopigmentation | 0.79712927 |
| 94 | MP0003763_abnormal_thymus_physiology | 0.79471138 |
| 95 | MP0002092_abnormal_eye_morphology | 0.79392930 |
| 96 | MP0000858_altered_metastatic_potential | 0.78278340 |
| 97 | MP0003787_abnormal_imprinting | 0.78171800 |
| 98 | MP0000537_abnormal_urethra_morphology | 0.77640781 |
| 99 | MP0010678_abnormal_skin_adnexa | 0.76281424 |
| 100 | MP0000689_abnormal_spleen_morphology | 0.75957381 |
| 101 | MP0006035_abnormal_mitochondrial_morpho | 0.75917420 |
| 102 | MP0006054_spinal_hemorrhage | 0.75517603 |
| 103 | MP0003943_abnormal_hepatobiliary_system | 0.74040899 |
| 104 | MP0002234_abnormal_pharynx_morphology | 0.73893995 |
| 105 | MP0003806_abnormal_nucleotide_metabolis | 0.73753236 |
| 106 | MP0005197_abnormal_uvea_morphology | 0.73587706 |
| 107 | MP0000733_abnormal_muscle_development | 0.73488031 |
| 108 | MP0004133_heterotaxia | 0.72929607 |
| 109 | MP0009703_decreased_birth_body | 0.72521554 |
| 110 | MP0003315_abnormal_perineum_morphology | 0.72206136 |
| 111 | MP0003448_altered_tumor_morphology | 0.69818669 |
| 112 | MP0002006_tumorigenesis | 0.69551871 |
| 113 | MP0000432_abnormal_head_morphology | 0.68811091 |
| 114 | MP0002925_abnormal_cardiovascular_devel | 0.67821579 |
| 115 | MP0004264_abnormal_extraembryonic_tissu | 0.67625952 |
| 116 | MP0009672_abnormal_birth_weight | 0.67602486 |
| 117 | MP0001286_abnormal_eye_development | 0.67413542 |
| 118 | MP0003115_abnormal_respiratory_system | 0.67147466 |
| 119 | MP0003699_abnormal_female_reproductive | 0.67111151 |
| 120 | MP0002177_abnormal_outer_ear | 0.66538942 |
| 121 | MP0009379_abnormal_foot_pigmentation | 0.66511059 |
| 122 | MP0003698_abnormal_male_reproductive | 0.65485000 |
| 123 | MP0000749_muscle_degeneration | 0.64862733 |
| 124 | MP0009333_abnormal_splenocyte_physiolog | 0.64769456 |
| 125 | MP0000477_abnormal_intestine_morphology | 0.64012442 |
| 126 | MP0003755_abnormal_palate_morphology | 0.63978157 |
| 127 | MP0002249_abnormal_larynx_morphology | 0.63179263 |
| 128 | MP0000569_abnormal_digit_pigmentation | 0.62717830 |
| 129 | MP0002429_abnormal_blood_cell | 0.61346321 |
| 130 | MP0002161_abnormal_fertility/fecundity | 0.61291173 |
| 131 | MP0003453_abnormal_keratinocyte_physiol | 0.60841573 |
| 132 | MP0002877_abnormal_melanocyte_morpholog | 0.59965986 |
| 133 | MP0010771_integument_phenotype | 0.58842276 |
| 134 | MP0005623_abnormal_meninges_morphology | 0.58664855 |
| 135 | MP0000358_abnormal_cell_content/ | 0.58356926 |
| 136 | MP0002697_abnormal_eye_size | 0.57702784 |
| 137 | MP0003935_abnormal_craniofacial_develop | 0.55682553 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Chromsome breakage (HP:0040012) | 5.01997315 |
| 2 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 4.79471436 |
| 3 | Abnormality of chromosome stability (HP:0003220) | 3.76196661 |
| 4 | Birth length less than 3rd percentile (HP:0003561) | 3.75711882 |
| 5 | Ependymoma (HP:0002888) | 3.53381363 |
| 6 | Meckel diverticulum (HP:0002245) | 3.42685668 |
| 7 | Abnormality of the preputium (HP:0100587) | 3.40135008 |
| 8 | Selective tooth agenesis (HP:0001592) | 3.35818139 |
| 9 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 3.31278399 |
| 10 | Breast hypoplasia (HP:0003187) | 3.29056388 |
| 11 | Absent radius (HP:0003974) | 3.27081153 |
| 12 | Abnormality of the ileum (HP:0001549) | 3.26994361 |
| 13 | Medulloblastoma (HP:0002885) | 3.25691708 |
| 14 | Abnormality of the labia minora (HP:0012880) | 3.22189401 |
| 15 | Reticulocytopenia (HP:0001896) | 3.09693489 |
| 16 | Patellar aplasia (HP:0006443) | 3.09608270 |
| 17 | Duodenal stenosis (HP:0100867) | 3.09141157 |
| 18 | Small intestinal stenosis (HP:0012848) | 3.09141157 |
| 19 | Premature rupture of membranes (HP:0001788) | 3.07519475 |
| 20 | Absent forearm bone (HP:0003953) | 3.07000447 |
| 21 | Aplasia involving forearm bones (HP:0009822) | 3.07000447 |
| 22 | Increased nuchal translucency (HP:0010880) | 3.05143247 |
| 23 | Colon cancer (HP:0003003) | 2.94573069 |
| 24 | Agnosia (HP:0010524) | 2.87593696 |
| 25 | Myelodysplasia (HP:0002863) | 2.87489986 |
| 26 | Rhabdomyosarcoma (HP:0002859) | 2.86100741 |
| 27 | Impulsivity (HP:0100710) | 2.84021585 |
| 28 | Supernumerary spleens (HP:0009799) | 2.83729344 |
| 29 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.83478788 |
| 30 | Hyperacusis (HP:0010780) | 2.80120546 |
| 31 | Ectopic kidney (HP:0000086) | 2.71088745 |
| 32 | Deviation of the thumb (HP:0009603) | 2.70014607 |
| 33 | Proximal placement of thumb (HP:0009623) | 2.69888396 |
| 34 | Volvulus (HP:0002580) | 2.69236088 |
| 35 | Abnormality of the umbilical cord (HP:0010881) | 2.68617117 |
| 36 | Sloping forehead (HP:0000340) | 2.64139512 |
| 37 | Facial hemangioma (HP:0000329) | 2.59394091 |
| 38 | Short nail (HP:0001799) | 2.58897265 |
| 39 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 2.57971831 |
| 40 | Osteolytic defects of the hand bones (HP:0009699) | 2.57971831 |
| 41 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.57455709 |
| 42 | Abnormality of the astrocytes (HP:0100707) | 2.57376191 |
| 43 | Astrocytoma (HP:0009592) | 2.57376191 |
| 44 | Absent thumb (HP:0009777) | 2.56250982 |
| 45 | Abnormality of the duodenum (HP:0002246) | 2.52962270 |
| 46 | Duplicated collecting system (HP:0000081) | 2.51750847 |
| 47 | Insomnia (HP:0100785) | 2.50246272 |
| 48 | Abnormality of the distal phalanges of the toes (HP:0010182) | 2.48219801 |
| 49 | Abnormal umbilical cord blood vessels (HP:0011403) | 2.47391348 |
| 50 | Single umbilical artery (HP:0001195) | 2.47391348 |
| 51 | Abnormality of the fetal cardiovascular system (HP:0010948) | 2.47391348 |
| 52 | Nephroblastoma (Wilms tumor) (HP:0002667) | 2.46341187 |
| 53 | Insidious onset (HP:0003587) | 2.45074303 |
| 54 | Termporal pattern (HP:0011008) | 2.45074303 |
| 55 | Increased connective tissue (HP:0009025) | 2.42229044 |
| 56 | Abnormal lung lobation (HP:0002101) | 2.41859188 |
| 57 | Oral leukoplakia (HP:0002745) | 2.41418231 |
| 58 | Neoplasm of the oral cavity (HP:0100649) | 2.40288950 |
| 59 | Cafe-au-lait spot (HP:0000957) | 2.38667151 |
| 60 | Degeneration of anterior horn cells (HP:0002398) | 2.38152888 |
| 61 | Abnormality of the anterior horn cell (HP:0006802) | 2.38152888 |
| 62 | Carpal bone hypoplasia (HP:0001498) | 2.36030372 |
| 63 | Entropion (HP:0000621) | 2.32437416 |
| 64 | Abnormality of the carotid arteries (HP:0005344) | 2.31608549 |
| 65 | 11 pairs of ribs (HP:0000878) | 2.30325060 |
| 66 | Embryonal renal neoplasm (HP:0011794) | 2.29595565 |
| 67 | Basal cell carcinoma (HP:0002671) | 2.28646209 |
| 68 | Deep philtrum (HP:0002002) | 2.27653920 |
| 69 | Ulnar bowing (HP:0003031) | 2.27096866 |
| 70 | Missing ribs (HP:0000921) | 2.26672483 |
| 71 | Abnormal number of incisors (HP:0011064) | 2.25143735 |
| 72 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 2.24438572 |
| 73 | Short 4th metacarpal (HP:0010044) | 2.24438572 |
| 74 | Neoplasm of striated muscle (HP:0009728) | 2.24133590 |
| 75 | Glioma (HP:0009733) | 2.23058149 |
| 76 | Bone marrow hypocellularity (HP:0005528) | 2.21927636 |
| 77 | Atresia of the external auditory canal (HP:0000413) | 2.15730636 |
| 78 | Poikiloderma (HP:0001029) | 2.15330575 |
| 79 | Abnormality of the renal collecting system (HP:0004742) | 2.14799248 |
| 80 | High pitched voice (HP:0001620) | 2.14341969 |
| 81 | Syringomyelia (HP:0003396) | 2.13689810 |
| 82 | Spinal cord lesions (HP:0100561) | 2.13689810 |
| 83 | Malignant gastrointestinal tract tumors (HP:0006749) | 2.13566212 |
| 84 | Gastrointestinal carcinoma (HP:0002672) | 2.13566212 |
| 85 | Asymmetry of the thorax (HP:0001555) | 2.11741776 |
| 86 | Microglossia (HP:0000171) | 2.11177018 |
| 87 | Neoplasm of the pancreas (HP:0002894) | 2.10140882 |
| 88 | Progressive muscle weakness (HP:0003323) | 2.09723060 |
| 89 | Abnormality of oral frenula (HP:0000190) | 2.09638061 |
| 90 | Ankyloglossia (HP:0010296) | 2.08538954 |
| 91 | Abnormality of the phalanges of the hallux (HP:0010057) | 2.08274762 |
| 92 | Clubbing of toes (HP:0100760) | 2.07908039 |
| 93 | Tracheoesophageal fistula (HP:0002575) | 2.07475316 |
| 94 | Short thumb (HP:0009778) | 2.07438538 |
| 95 | Triphalangeal thumb (HP:0001199) | 2.06726116 |
| 96 | Heterotopia (HP:0002282) | 2.03085373 |
| 97 | Trismus (HP:0000211) | 2.03005996 |
| 98 | Squamous cell carcinoma (HP:0002860) | 2.02685439 |
| 99 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 2.02649408 |
| 100 | Prominent nose (HP:0000448) | 2.02287281 |
| 101 | Progressive external ophthalmoplegia (HP:0000590) | 2.00922045 |
| 102 | Cortical dysplasia (HP:0002539) | 2.00610314 |
| 103 | Multiple enchondromatosis (HP:0005701) | 2.00323013 |
| 104 | Urethral obstruction (HP:0000796) | 2.00053114 |
| 105 | Reduced subcutaneous adipose tissue (HP:0003758) | 1.99476730 |
| 106 | Biliary tract neoplasm (HP:0100574) | 1.98156488 |
| 107 | Horseshoe kidney (HP:0000085) | 1.96059516 |
| 108 | Aplasia/hypoplasia of the humerus (HP:0006507) | 1.95794748 |
| 109 | Sandal gap (HP:0001852) | 1.92876805 |
| 110 | Fragile skin (HP:0001030) | 1.92555831 |
| 111 | Abnormality of abdominal situs (HP:0011620) | 1.92325896 |
| 112 | Abdominal situs inversus (HP:0003363) | 1.92325896 |
| 113 | Neoplasm of the colon (HP:0100273) | 1.90796283 |
| 114 | Abnormal foot bone ossification (HP:0010675) | 1.90197056 |
| 115 | Hereditary nonpolyposis colorectal carcinoma (HP:0006716) | 1.90065777 |
| 116 | Abnormal auditory evoked potentials (HP:0006958) | 1.89852484 |
| 117 | Abnormality of the distal phalanx of the thumb (HP:0009617) | 1.88986296 |
| 118 | Ankle contracture (HP:0006466) | 1.88892178 |
| 119 | Abnormalities of placenta or umbilical cord (HP:0001194) | 1.88634504 |
| 120 | Renal duplication (HP:0000075) | 1.86937682 |
| 121 | Unilateral renal agenesis (HP:0000122) | 1.86532167 |
| 122 | Ovarian neoplasm (HP:0100615) | 1.85642975 |
| 123 | Abnormality of the calcaneus (HP:0008364) | 1.84196251 |
| 124 | Orthostatic hypotension (HP:0001278) | 1.83573511 |
| 125 | Short humerus (HP:0005792) | 1.83371241 |
| 126 | Distal lower limb amyotrophy (HP:0008944) | 1.83196308 |
| 127 | Rib fusion (HP:0000902) | 1.83011769 |
| 128 | Abnormality of chromosome segregation (HP:0002916) | 1.82782926 |
| 129 | Protrusio acetabuli (HP:0003179) | 1.82379225 |
| 130 | Overriding aorta (HP:0002623) | 1.82229399 |
| 131 | Duplication of thumb phalanx (HP:0009942) | 1.81868566 |
| 132 | Abnormality of DNA repair (HP:0003254) | 1.81308366 |
| 133 | Achilles tendon contracture (HP:0001771) | 1.80294080 |
| 134 | Overlapping toe (HP:0001845) | 1.79027405 |
| 135 | Skull defect (HP:0001362) | 1.78664009 |
| 136 | Elbow flexion contracture (HP:0002987) | 1.78579329 |
| 137 | Shawl scrotum (HP:0000049) | 1.77914234 |
| 138 | Microvesicular hepatic steatosis (HP:0001414) | 1.76860246 |
| 139 | Amaurosis fugax (HP:0100576) | 1.75307394 |
| 140 | Ureteral duplication (HP:0000073) | 1.75195303 |
| 141 | Rough bone trabeculation (HP:0100670) | 1.75053362 |
| 142 | Premature graying of hair (HP:0002216) | 1.74747713 |
| 143 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 1.74473913 |
| 144 | Choanal atresia (HP:0000453) | 1.73615226 |
| 145 | Elfin facies (HP:0004428) | 1.73523075 |
| 146 | Abnormality of the salivary glands (HP:0010286) | 1.71506047 |
| 147 | Natal tooth (HP:0000695) | 1.71116895 |
| 148 | Uterine neoplasm (HP:0010784) | 1.71023739 |
| 149 | Aplastic anemia (HP:0001915) | 1.70502063 |
| 150 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.69908660 |
| 151 | Flat acetabular roof (HP:0003180) | 1.68609539 |
| 152 | Glossoptosis (HP:0000162) | 1.67486970 |
| 153 | Leiomyosarcoma (HP:0100243) | 1.65684486 |
| 154 | Uterine leiomyosarcoma (HP:0002891) | 1.65684486 |
| 155 | Spinal cord compression (HP:0002176) | 1.65419370 |
| 156 | Progressive hearing impairment (HP:0001730) | 1.65132297 |
| 157 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 1.64490690 |
| 158 | Spinal rigidity (HP:0003306) | 1.64219782 |
| 159 | Arteriovenous malformation (HP:0100026) | 1.63118100 |
| 160 | Vertebral arch anomaly (HP:0008438) | 1.62790957 |
| 161 | Broad face (HP:0000283) | 1.60247323 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 5.14533236 |
| 2 | CDC7 | 4.78372153 |
| 3 | WEE1 | 3.97186433 |
| 4 | NEK2 | 3.72981151 |
| 5 | TTK | 3.31031391 |
| 6 | MST1R | 2.84359119 |
| 7 | CDK12 | 2.79614036 |
| 8 | NEK1 | 2.78438860 |
| 9 | * PLK1 | 2.24317317 |
| 10 | BRSK2 | 2.21216897 |
| 11 | EEF2K | 2.13329857 |
| 12 | PLK4 | 2.09477768 |
| 13 | TRIB3 | 2.03647037 |
| 14 | AURKB | 1.97247133 |
| 15 | ACVR1B | 1.95548969 |
| 16 | SRPK1 | 1.84291357 |
| 17 | STK10 | 1.82265951 |
| 18 | EIF2AK1 | 1.81707812 |
| 19 | RPS6KB2 | 1.79471674 |
| 20 | IRAK3 | 1.78958780 |
| 21 | CHEK2 | 1.73707371 |
| 22 | ATR | 1.73320518 |
| 23 | PLK3 | 1.62209752 |
| 24 | CDK7 | 1.62082862 |
| 25 | MET | 1.61643299 |
| 26 | MAP3K8 | 1.55921903 |
| 27 | TESK2 | 1.54437810 |
| 28 | SMG1 | 1.53410832 |
| 29 | CDK4 | 1.52720110 |
| 30 | CHEK1 | 1.46535233 |
| 31 | MELK | 1.42334185 |
| 32 | BRSK1 | 1.42181160 |
| 33 | PASK | 1.41233885 |
| 34 | STK4 | 1.36205522 |
| 35 | TLK1 | 1.35182309 |
| 36 | EPHA2 | 1.33842990 |
| 37 | SCYL2 | 1.33618436 |
| 38 | RPS6KA4 | 1.28353421 |
| 39 | MKNK1 | 1.28098698 |
| 40 | PKN2 | 1.28084203 |
| 41 | MAP3K10 | 1.24878883 |
| 42 | AURKA | 1.22394616 |
| 43 | ICK | 1.20200219 |
| 44 | DYRK3 | 1.18935703 |
| 45 | MST4 | 1.17991485 |
| 46 | EIF2AK3 | 1.14104374 |
| 47 | TAF1 | 1.13104996 |
| 48 | PDGFRA | 1.10828992 |
| 49 | STK3 | 1.09575649 |
| 50 | ATM | 1.07570327 |
| 51 | PAK4 | 1.07391043 |
| 52 | PTK2 | 1.06957000 |
| 53 | TSSK6 | 1.06887803 |
| 54 | VRK1 | 1.06418456 |
| 55 | LATS1 | 1.04412734 |
| 56 | VRK2 | 0.97719569 |
| 57 | CCNB1 | 0.97001845 |
| 58 | CDK2 | 0.95070878 |
| 59 | TGFBR1 | 0.90870325 |
| 60 | BRD4 | 0.89344117 |
| 61 | CDK6 | 0.89001152 |
| 62 | MKNK2 | 0.83405056 |
| 63 | CDK8 | 0.82280290 |
| 64 | MAPKAPK3 | 0.81171223 |
| 65 | MAP3K9 | 0.79519066 |
| 66 | TESK1 | 0.76905055 |
| 67 | FLT3 | 0.76771938 |
| 68 | * CDK1 | 0.75743284 |
| 69 | PIM1 | 0.74456456 |
| 70 | BRAF | 0.67470487 |
| 71 | ILK | 0.67367670 |
| 72 | LIMK1 | 0.66958079 |
| 73 | LRRK2 | 0.66581397 |
| 74 | ALK | 0.65736939 |
| 75 | ZAK | 0.64642778 |
| 76 | PBK | 0.64590658 |
| 77 | LATS2 | 0.64221938 |
| 78 | SIK1 | 0.63070707 |
| 79 | STK38L | 0.60361081 |
| 80 | MAP4K1 | 0.60217772 |
| 81 | PAK1 | 0.58346551 |
| 82 | TTN | 0.57323768 |
| 83 | CDK9 | 0.55178901 |
| 84 | ARAF | 0.54805579 |
| 85 | KSR1 | 0.51938469 |
| 86 | MTOR | 0.51338406 |
| 87 | ERBB3 | 0.50942367 |
| 88 | CSNK2A2 | 0.46052301 |
| 89 | MAP3K12 | 0.45934162 |
| 90 | PRKCI | 0.45370261 |
| 91 | NME2 | 0.44530167 |
| 92 | CDK18 | 0.43685307 |
| 93 | CSNK2A1 | 0.43048267 |
| 94 | EIF2AK2 | 0.42422896 |
| 95 | FGFR1 | 0.42326687 |
| 96 | CDK15 | 0.41465530 |
| 97 | CLK1 | 0.40824012 |
| 98 | CDK11A | 0.40081433 |
| 99 | DMPK | 0.39809434 |
| 100 | TRIM28 | 0.39112519 |
| 101 | CSNK1D | 0.38558904 |
| 102 | PRKDC | 0.37458600 |
| 103 | RAF1 | 0.36233121 |
| 104 | CDK14 | 0.35644221 |
| 105 | AKT2 | 0.34879112 |
| 106 | PRPF4B | 0.34263487 |
| 107 | GRK6 | 0.34136415 |
| 108 | MAPK14 | 0.30492163 |
| 109 | MAPK11 | 0.30340360 |
| 110 | ERBB4 | 0.30322655 |
| 111 | MAP3K6 | 0.29428863 |
| 112 | PDK4 | 0.29067730 |
| 113 | PDK3 | 0.29067730 |
| 114 | CSF1R | 0.28803821 |
| 115 | FGFR3 | 0.28185432 |
| 116 | PNCK | 0.28007926 |
| 117 | RPS6KA5 | 0.27236419 |
| 118 | MOS | 0.26983719 |
| 119 | CSNK1E | 0.26977766 |
| 120 | MARK3 | 0.25637244 |
| 121 | AKT1 | 0.24130302 |
| 122 | NEK9 | 0.22527049 |
| 123 | PAK2 | 0.21138686 |
| 124 | NUAK1 | 0.20756154 |
| 125 | * MAPK1 | 0.20516530 |
| 126 | GSK3B | 0.19320451 |
| 127 | TRPM7 | 0.19204793 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 4.92301316 |
| 2 | Mismatch repair_Homo sapiens_hsa03430 | 4.47088311 |
| 3 | Cell cycle_Homo sapiens_hsa04110 | 3.53220318 |
| 4 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.38639735 |
| 5 | RNA transport_Homo sapiens_hsa03013 | 3.19610736 |
| 6 | Homologous recombination_Homo sapiens_hsa03440 | 3.17687283 |
| 7 | Base excision repair_Homo sapiens_hsa03410 | 3.16688095 |
| 8 | Spliceosome_Homo sapiens_hsa03040 | 3.03919597 |
| 9 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.83288119 |
| 10 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.74899429 |
| 11 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.73835389 |
| 12 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.36831259 |
| 13 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.28504415 |
| 14 | RNA degradation_Homo sapiens_hsa03018 | 2.17390572 |
| 15 | RNA polymerase_Homo sapiens_hsa03020 | 2.07722785 |
| 16 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 2.05538362 |
| 17 | p53 signaling pathway_Homo sapiens_hsa04115 | 2.00493868 |
| 18 | Basal transcription factors_Homo sapiens_hsa03022 | 1.98231732 |
| 19 | Ribosome_Homo sapiens_hsa03010 | 1.85281312 |
| 20 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.80385154 |
| 21 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.63380698 |
| 22 | Proteasome_Homo sapiens_hsa03050 | 1.59730840 |
| 23 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.50234628 |
| 24 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.45411089 |
| 25 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.34760300 |
| 26 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.33897047 |
| 27 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.30601926 |
| 28 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.20767943 |
| 29 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.10624477 |
| 30 | HTLV-I infection_Homo sapiens_hsa05166 | 1.06128706 |
| 31 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.02971875 |
| 32 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.99161026 |
| 33 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.97680229 |
| 34 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.97017121 |
| 35 | Purine metabolism_Homo sapiens_hsa00230 | 0.85953034 |
| 36 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.81935143 |
| 37 | Colorectal cancer_Homo sapiens_hsa05210 | 0.80975456 |
| 38 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.78791726 |
| 39 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.78249054 |
| 40 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.76887699 |
| 41 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.76812515 |
| 42 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.76130968 |
| 43 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.75967760 |
| 44 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.75313068 |
| 45 | Thyroid cancer_Homo sapiens_hsa05216 | 0.74938467 |
| 46 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.73763417 |
| 47 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.73756853 |
| 48 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.72234844 |
| 49 | Adherens junction_Homo sapiens_hsa04520 | 0.68502987 |
| 50 | Glioma_Homo sapiens_hsa05214 | 0.66028173 |
| 51 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.65516316 |
| 52 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.64384863 |
| 53 | Apoptosis_Homo sapiens_hsa04210 | 0.63333153 |
| 54 | Alcoholism_Homo sapiens_hsa05034 | 0.62924602 |
| 55 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.62235471 |
| 56 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.61507272 |
| 57 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.61208998 |
| 58 | Bladder cancer_Homo sapiens_hsa05219 | 0.61190023 |
| 59 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.57087309 |
| 60 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.55980992 |
| 61 | Hepatitis B_Homo sapiens_hsa05161 | 0.55392685 |
| 62 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.55207173 |
| 63 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.53144895 |
| 64 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.53098047 |
| 65 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.52144222 |
| 66 | Shigellosis_Homo sapiens_hsa05131 | 0.50529811 |
| 67 | Legionellosis_Homo sapiens_hsa05134 | 0.49897834 |
| 68 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.48358118 |
| 69 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.48220767 |
| 70 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.48200180 |
| 71 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.47486508 |
| 72 | Pathways in cancer_Homo sapiens_hsa05200 | 0.46976614 |
| 73 | Viral myocarditis_Homo sapiens_hsa05416 | 0.46708910 |
| 74 | Sulfur relay system_Homo sapiens_hsa04122 | 0.45772119 |
| 75 | Galactose metabolism_Homo sapiens_hsa00052 | 0.45692805 |
| 76 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.43648780 |
| 77 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.42264748 |
| 78 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.40100782 |
| 79 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.40025178 |
| 80 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.38906474 |
| 81 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.38804069 |
| 82 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.38747254 |
| 83 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.37828007 |
| 84 | Prostate cancer_Homo sapiens_hsa05215 | 0.37318226 |
| 85 | Measles_Homo sapiens_hsa05162 | 0.36618709 |
| 86 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.36585774 |
| 87 | Influenza A_Homo sapiens_hsa05164 | 0.35933424 |
| 88 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.35790206 |
| 89 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.35326791 |
| 90 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.34430799 |
| 91 | Protein export_Homo sapiens_hsa03060 | 0.34389122 |
| 92 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.34227302 |
| 93 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.34074177 |
| 94 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.33835851 |
| 95 | Lysine degradation_Homo sapiens_hsa00310 | 0.33685585 |
| 96 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.31554937 |
| 97 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.31408121 |
| 98 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.30880808 |
| 99 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.30454171 |
| 100 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.30324335 |
| 101 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.29359995 |
| 102 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.29095900 |
| 103 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.28640920 |
| 104 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.28509484 |
| 105 | Tight junction_Homo sapiens_hsa04530 | 0.27417879 |
| 106 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.24191565 |
| 107 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.23657440 |
| 108 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.23264553 |
| 109 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.22932055 |
| 110 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.22511986 |
| 111 | Gap junction_Homo sapiens_hsa04540 | 0.21715765 |
| 112 | Salmonella infection_Homo sapiens_hsa05132 | 0.21666570 |
| 113 | Melanoma_Homo sapiens_hsa05218 | 0.21347387 |
| 114 | Endometrial cancer_Homo sapiens_hsa05213 | 0.20414430 |
| 115 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.20185250 |
| 116 | Carbon metabolism_Homo sapiens_hsa01200 | 0.19710730 |
| 117 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.19616654 |
| 118 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.19153425 |
| 119 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.18733138 |
| 120 | Focal adhesion_Homo sapiens_hsa04510 | 0.18684184 |
| 121 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.18649031 |
| 122 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.16822712 |
| 123 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.14235044 |
| 124 | Leishmaniasis_Homo sapiens_hsa05140 | 0.13116883 |

