CEP57

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in this gene cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1melanin biosynthetic process (GO:0042438)4.10516692
2telomere maintenance via semi-conservative replication (GO:0032201)4.07427818
3kinetochore organization (GO:0051383)3.95830704
4CENP-A containing nucleosome assembly (GO:0034080)3.89486968
5telomere maintenance via recombination (GO:0000722)3.89314739
6secondary metabolite biosynthetic process (GO:0044550)3.88891144
7chromatin remodeling at centromere (GO:0031055)3.87368834
8DNA strand elongation involved in DNA replication (GO:0006271)3.82421901
9resolution of meiotic recombination intermediates (GO:0000712)3.78694282
10regulation of nuclear cell cycle DNA replication (GO:0033262)3.78380700
11melanin metabolic process (GO:0006582)3.77584380
12mitotic recombination (GO:0006312)3.74044201
13DNA strand elongation (GO:0022616)3.72958350
14nuclear pore complex assembly (GO:0051292)3.67928380
15DNA replication initiation (GO:0006270)3.66707265
16microtubule depolymerization (GO:0007019)3.63549359
17kinetochore assembly (GO:0051382)3.57759025
18DNA replication checkpoint (GO:0000076)3.54617482
19meiotic chromosome segregation (GO:0045132)3.54474766
20synapsis (GO:0007129)3.51739241
21nuclear pore organization (GO:0006999)3.49599958
22DNA replication-independent nucleosome assembly (GO:0006336)3.42397042
23DNA replication-independent nucleosome organization (GO:0034724)3.42397042
24protein K6-linked ubiquitination (GO:0085020)3.41416788
25negative regulation of DNA-dependent DNA replication (GO:2000104)3.38433556
26nucleotide-excision repair, DNA gap filling (GO:0006297)3.38071223
27mitotic metaphase plate congression (GO:0007080)3.36822670
28telomere maintenance via telomere lengthening (GO:0010833)3.35341358
29histone exchange (GO:0043486)3.33579161
30neural tube formation (GO:0001841)3.32313244
31protein localization to chromosome, centromeric region (GO:0071459)3.30016220
32centriole assembly (GO:0098534)3.29233553
33mismatch repair (GO:0006298)3.29208206
34attachment of spindle microtubules to kinetochore (GO:0008608)3.28037755
35intraciliary transport (GO:0042073)3.26190951
36cullin deneddylation (GO:0010388)3.24679402
37regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.24186103
38regulation of mitotic spindle checkpoint (GO:1903504)3.24186103
39somatic hypermutation of immunoglobulin genes (GO:0016446)3.23653650
40somatic diversification of immune receptors via somatic mutation (GO:0002566)3.23653650
41pore complex assembly (GO:0046931)3.23048412
42DNA deamination (GO:0045006)3.21806631
43double-strand break repair via nonhomologous end joining (GO:0006303)3.17399650
44non-recombinational repair (GO:0000726)3.17399650
45metaphase plate congression (GO:0051310)3.14968520
46establishment of chromosome localization (GO:0051303)3.14963470
47recombinational repair (GO:0000725)3.13870947
48protein localization to kinetochore (GO:0034501)3.13819240
49centriole replication (GO:0007099)3.12600101
50intra-S DNA damage checkpoint (GO:0031573)3.08769355
51double-strand break repair via homologous recombination (GO:0000724)3.08438313
52mitotic sister chromatid cohesion (GO:0007064)3.08233039
53proteasome assembly (GO:0043248)3.06810975
54regulation of double-strand break repair via homologous recombination (GO:0010569)3.05220237
55telomere maintenance (GO:0000723)3.03031627
56regulation of DNA endoreduplication (GO:0032875)3.01436580
57telomere organization (GO:0032200)2.98859591
58histone H2A acetylation (GO:0043968)2.96798433
59regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.92366147
60negative regulation of DNA recombination (GO:0045910)2.91479623
61transcription-coupled nucleotide-excision repair (GO:0006283)2.90782872
62DNA synthesis involved in DNA repair (GO:0000731)2.90012722
63reciprocal DNA recombination (GO:0035825)2.89874072
64reciprocal meiotic recombination (GO:0007131)2.89874072
65ribosomal small subunit assembly (GO:0000028)2.88951659
66DNA strand renaturation (GO:0000733)2.86993985
67mitotic chromosome condensation (GO:0007076)2.86578317
68spindle checkpoint (GO:0031577)2.85067257
69DNA double-strand break processing (GO:0000729)2.84657978
70regulation of mitotic metaphase/anaphase transition (GO:0030071)2.83771598
71mitotic sister chromatid segregation (GO:0000070)2.83494084
72chromosome segregation (GO:0007059)2.82947388
73negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.82886320
74negative regulation of sister chromatid segregation (GO:0033046)2.82886320
75negative regulation of mitotic sister chromatid separation (GO:2000816)2.82886320
76negative regulation of mitotic sister chromatid segregation (GO:0033048)2.82886320
77protein prenylation (GO:0018342)2.82174017
78prenylation (GO:0097354)2.82174017
79viral mRNA export from host cell nucleus (GO:0046784)2.81669857
80maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.79955584
81protein deneddylation (GO:0000338)2.79099789
82inositol phosphate catabolic process (GO:0071545)2.78961789
83negative regulation of chromosome segregation (GO:0051985)2.78868598
84regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.78315245
85DNA ligation (GO:0006266)2.77577387
86regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.77275157
87replication fork processing (GO:0031297)2.76384822
88spindle assembly checkpoint (GO:0071173)2.75925183
89cell wall macromolecule catabolic process (GO:0016998)2.75450983
90cell wall macromolecule metabolic process (GO:0044036)2.75450983
91mitotic G2 DNA damage checkpoint (GO:0007095)2.74566450
92negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.74505199
93regulation of sister chromatid segregation (GO:0033045)2.73922945
94regulation of mitotic sister chromatid separation (GO:0010965)2.73922945
95regulation of mitotic sister chromatid segregation (GO:0033047)2.73922945
96ketone body metabolic process (GO:1902224)2.73816062
97DNA-dependent DNA replication (GO:0006261)2.73313873
98cilium or flagellum-dependent cell motility (GO:0001539)2.72854106
99ATP-dependent chromatin remodeling (GO:0043044)2.72804421
100DNA replication-dependent nucleosome organization (GO:0034723)2.72238648
101DNA replication-dependent nucleosome assembly (GO:0006335)2.72238648
102mitotic nuclear envelope disassembly (GO:0007077)2.71817912
103DNA unwinding involved in DNA replication (GO:0006268)2.71814540
104regulation of helicase activity (GO:0051095)2.71252684
105postreplication repair (GO:0006301)2.69794312
106deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.69054898
107DNA catabolic process, exonucleolytic (GO:0000738)2.69022972
108regulation of sister chromatid cohesion (GO:0007063)2.68896328
109RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.68708286
110sister chromatid segregation (GO:0000819)2.68374654
111centrosome organization (GO:0051297)2.67436241
112regulation of chromosome segregation (GO:0051983)2.66302487
113regulation of centrosome cycle (GO:0046605)2.65116488
114positive regulation of mitotic sister chromatid separation (GO:1901970)2.64871977
115positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.64871977
116positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.64871977
117mitotic spindle assembly checkpoint (GO:0007094)2.64790460
118mitotic spindle checkpoint (GO:0071174)2.64405023
119presynaptic membrane assembly (GO:0097105)2.62795769
120DNA damage response, detection of DNA damage (GO:0042769)2.61730853
121nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.61660780
122sister chromatid cohesion (GO:0007062)2.61521158
123DNA topological change (GO:0006265)2.61458960
124regulation of spindle checkpoint (GO:0090231)2.61181687
125DNA replication (GO:0006260)2.60783663
126sperm-egg recognition (GO:0035036)2.60775752
127regulation of centriole replication (GO:0046599)2.60665052
128protein localization to chromosome (GO:0034502)2.60099635
129DNA packaging (GO:0006323)2.59860113
130pyrimidine nucleobase catabolic process (GO:0006208)2.59488174
131tRNA methylation (GO:0030488)2.58207854
132piRNA metabolic process (GO:0034587)2.57972781
133mitotic G2/M transition checkpoint (GO:0044818)2.57879314
134microtubule organizing center organization (GO:0031023)2.57843879
135purine nucleobase biosynthetic process (GO:0009113)2.57621555
136regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.56293857
137response to pheromone (GO:0019236)2.56100580

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.22088206
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.12249562
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.85996036
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.78147384
5* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.47604411
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.11108568
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.96128012
8ZNF274_21170338_ChIP-Seq_K562_Hela2.75015747
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.64240694
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.44234779
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.37072657
12IGF1R_20145208_ChIP-Seq_DFB_Human2.35406339
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.33096340
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.29679981
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.27696961
16VDR_22108803_ChIP-Seq_LS180_Human2.22918895
17* ELF1_17652178_ChIP-ChIP_JURKAT_Human2.16628089
18VDR_23849224_ChIP-Seq_CD4+_Human2.16366817
19* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.09880022
20TAF15_26573619_Chip-Seq_HEK293_Human2.09015060
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.06397695
22E2F1_21310950_ChIP-Seq_MCF-7_Human2.06311346
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.05341813
24* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.04627309
25ELK1_19687146_ChIP-ChIP_HELA_Human2.04127561
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.03566081
27* FOXP3_21729870_ChIP-Seq_TREG_Human1.97995546
28* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.97885629
29* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.96125796
30GBX2_23144817_ChIP-Seq_PC3_Human1.93461317
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.89323399
32ETS1_20019798_ChIP-Seq_JURKAT_Human1.88736250
33NELFA_20434984_ChIP-Seq_ESCs_Mouse1.86518123
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84439643
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.83207855
36RBPJ_22232070_ChIP-Seq_NCS_Mouse1.83026741
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.83021588
38CREB1_15753290_ChIP-ChIP_HEK293T_Human1.82273920
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.82045128
40SALL1_21062744_ChIP-ChIP_HESCs_Human1.79647153
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78412212
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.77757592
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.75978546
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.74303349
45* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.74166163
46P300_19829295_ChIP-Seq_ESCs_Human1.71788924
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71306619
48IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.66766017
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.65307476
50* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60092802
51TTF2_22483619_ChIP-Seq_HELA_Human1.54909283
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.53058431
53AR_21909140_ChIP-Seq_LNCAP_Human1.52411914
54EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.51706880
55* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.50983738
56DCP1A_22483619_ChIP-Seq_HELA_Human1.50307321
57XRN2_22483619_ChIP-Seq_HELA_Human1.46636150
58FLI1_27457419_Chip-Seq_LIVER_Mouse1.45695296
59CIITA_25753668_ChIP-Seq_RAJI_Human1.43045526
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42027543
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.41275538
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41228534
63* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.40964205
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40846514
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.39847418
66RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38000447
67TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36342642
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35629039
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34776943
70EGR1_19374776_ChIP-ChIP_THP-1_Human1.34634231
71GABP_19822575_ChIP-Seq_HepG2_Human1.34401493
72ERG_20887958_ChIP-Seq_HPC-7_Mouse1.33772866
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33545184
74YY1_21170310_ChIP-Seq_MESCs_Mouse1.32007581
75SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.31834580
76ER_23166858_ChIP-Seq_MCF-7_Human1.28665979
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28112925
78AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27778758
79NANOG_18555785_ChIP-Seq_MESCs_Mouse1.27123989
80IRF1_19129219_ChIP-ChIP_H3396_Human1.26487889
81THAP11_20581084_ChIP-Seq_MESCs_Mouse1.24626627
82* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23069871
83SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22659695
84RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.22483187
85POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.20711332
86CBP_20019798_ChIP-Seq_JUKART_Human1.20489769
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20489769
88SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.20011383
89CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.17217879
90FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.16609013
91ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15440770
92OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14375909
93ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.13005825
94POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12824582
95SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12760031
96SMAD4_21799915_ChIP-Seq_A2780_Human1.12625654
97DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.11954943
98IRF8_22096565_ChIP-ChIP_GC-B_Human1.10747084
99SCL_19346495_ChIP-Seq_HPC-7_Human1.09310003
100STAT3_23295773_ChIP-Seq_U87_Human1.05746109
101IRF8_21731497_ChIP-ChIP_J774_Mouse1.05548514
102SPI1_23547873_ChIP-Seq_NB4_Human1.05150302
103TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04393824
104GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03122345
105SOX2_16153702_ChIP-ChIP_HESCs_Human1.02481534
106MYC_18940864_ChIP-ChIP_HL60_Human1.02454113
107GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01740898
108KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99983299
109* TCF4_23295773_ChIP-Seq_U87_Human0.99916356
110TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99504738
111PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98585722
112EWS_26573619_Chip-Seq_HEK293_Human0.98539368
113EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98000617
114NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.97570586
115* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97484520
116SMAD3_21741376_ChIP-Seq_EPCs_Human0.97275725
117NANOG_18555785_Chip-Seq_ESCs_Mouse0.97203509
118TP53_22573176_ChIP-Seq_HFKS_Human0.97053640
119KDM5A_27292631_Chip-Seq_BREAST_Human0.96679412
120PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96582343
121E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.96410178
122NFE2_27457419_Chip-Seq_LIVER_Mouse0.96309819
123TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96179950
124HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94835082
125* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94760041
126SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94319865
127RUNX2_22187159_ChIP-Seq_PCA_Human0.94006826
128SOX9_26525672_Chip-Seq_HEART_Mouse0.92469282
129RNF2_27304074_Chip-Seq_NSC_Mouse0.92374134
130* FUS_26573619_Chip-Seq_HEK293_Human0.91327208
131* AR_25329375_ChIP-Seq_VCAP_Human0.90822455
132CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.90423120
133KAP1_22055183_ChIP-Seq_ESCs_Mouse0.90164073
134PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.89807047
135BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.89365712
136* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.88723301
137SUZ12_27294783_Chip-Seq_NPCs_Mouse0.86967173
138SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.83135394
139STAT4_19710469_ChIP-ChIP_TH1__Mouse0.81640621
140POU5F1_16153702_ChIP-ChIP_HESCs_Human0.80445985
141TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75127723
142* TFEB_21752829_ChIP-Seq_HELA_Human0.74770269
143SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.73376235
144* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.71767270
145PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.70090601
146EZH2_27294783_Chip-Seq_NPCs_Mouse0.69960399
147MYB_26560356_Chip-Seq_TH2_Human0.69060800
148POU3F2_20337985_ChIP-ChIP_501MEL_Human0.68167906

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.20307610
2MP0010094_abnormal_chromosome_stability4.14721658
3MP0003693_abnormal_embryo_hatching3.75946878
4MP0008058_abnormal_DNA_repair3.72693367
5MP0003111_abnormal_nucleus_morphology3.67294028
6MP0003077_abnormal_cell_cycle3.18545167
7MP0008007_abnormal_cellular_replicative2.84352249
8MP0008877_abnormal_DNA_methylation2.79667547
9MP0006292_abnormal_olfactory_placode2.71970488
10MP0004957_abnormal_blastocyst_morpholog2.54993483
11MP0000569_abnormal_digit_pigmentation2.33547149
12MP0002396_abnormal_hematopoietic_system2.16013277
13MP0005408_hypopigmentation2.13249965
14MP0003786_premature_aging2.04859881
15MP0008932_abnormal_embryonic_tissue1.86979458
16MP0005410_abnormal_fertilization1.82970778
17MP0003136_yellow_coat_color1.81521125
18MP0003763_abnormal_thymus_physiology1.79905693
19MP0003787_abnormal_imprinting1.78601831
20MP0000490_abnormal_crypts_of1.73595131
21MP0001835_abnormal_antigen_presentation1.66769847
22MP0002277_abnormal_respiratory_mucosa1.61413928
23MP0000015_abnormal_ear_pigmentation1.59304884
24MP0001324_abnormal_eye_pigmentation1.57394397
25MP0001929_abnormal_gametogenesis1.54209991
26MP0002210_abnormal_sex_determination1.52902223
27MP0002009_preneoplasia1.51658975
28MP0004147_increased_porphyrin_level1.49340924
29MP0005174_abnormal_tail_pigmentation1.49332581
30MP0005253_abnormal_eye_physiology1.49046842
31MP0003121_genomic_imprinting1.46853466
32MP0002822_catalepsy1.45368308
33MP0003806_abnormal_nucleotide_metabolis1.44781291
34MP0003941_abnormal_skin_development1.43557520
35MP0002160_abnormal_reproductive_system1.43452627
36MP0001529_abnormal_vocalization1.42430164
37MP0004808_abnormal_hematopoietic_stem1.42179584
38MP0003880_abnormal_central_pattern1.38498910
39MP0001984_abnormal_olfaction1.38434480
40MP0005075_abnormal_melanosome_morpholog1.37178699
41MP0000350_abnormal_cell_proliferation1.35490546
42MP0005551_abnormal_eye_electrophysiolog1.30423522
43MP0002095_abnormal_skin_pigmentation1.29653661
44MP0001188_hyperpigmentation1.28400971
45MP0010307_abnormal_tumor_latency1.28155220
46MP0002398_abnormal_bone_marrow1.27854004
47MP0009697_abnormal_copulation1.27846991
48MP0004885_abnormal_endolymph1.26294658
49MP0002132_abnormal_respiratory_system1.25239117
50MP0002234_abnormal_pharynx_morphology1.24711057
51MP0001145_abnormal_male_reproductive1.22299816
52MP0005389_reproductive_system_phenotype1.21529157
53MP0000372_irregular_coat_pigmentation1.21078745
54MP0006072_abnormal_retinal_apoptosis1.20782655
55MP0000313_abnormal_cell_death1.19499859
56MP0005671_abnormal_response_to1.19104659
57MP0000631_abnormal_neuroendocrine_gland1.17876343
58MP0001293_anophthalmia1.15696488
59MP0003315_abnormal_perineum_morphology1.15570082
60MP0008789_abnormal_olfactory_epithelium1.15272639
61MP0000703_abnormal_thymus_morphology1.14065229
62MP0003698_abnormal_male_reproductive1.12026240
63MP0002638_abnormal_pupillary_reflex1.11421674
64MP0000653_abnormal_sex_gland1.10688012
65MP0001119_abnormal_female_reproductive1.10526575
66MP0002102_abnormal_ear_morphology1.10263371
67MP0003890_abnormal_embryonic-extraembry1.08218562
68MP0002233_abnormal_nose_morphology1.08026675
69MP0002653_abnormal_ependyma_morphology1.06387759
70MP0002019_abnormal_tumor_incidence1.06246365
71MP0000647_abnormal_sebaceous_gland1.06224090
72MP0005248_abnormal_Harderian_gland1.03964651
73MP0001919_abnormal_reproductive_system1.03326647
74MP0000689_abnormal_spleen_morphology1.01317823
75MP0001800_abnormal_humoral_immune1.00839546
76MP0000778_abnormal_nervous_system1.00241910
77MP0000427_abnormal_hair_cycle0.99741287
78MP0005391_vision/eye_phenotype0.99337876
79MP0000566_synostosis0.99202862
80MP0004133_heterotaxia0.98789675
81MP0002722_abnormal_immune_system0.98631402
82MP0000516_abnormal_urinary_system0.97650727
83MP0005367_renal/urinary_system_phenotyp0.97650727
84MP0002452_abnormal_antigen_presenting0.97529326
85MP0001986_abnormal_taste_sensitivity0.97216269
86MP0001186_pigmentation_phenotype0.96986161
87MP0002090_abnormal_vision0.96439094
88MP0002420_abnormal_adaptive_immunity0.95426280
89MP0005380_embryogenesis_phenotype0.94619989
90MP0001672_abnormal_embryogenesis/_devel0.94619989
91MP0009333_abnormal_splenocyte_physiolog0.94318009
92MP0001485_abnormal_pinna_reflex0.94301887
93MP0001819_abnormal_immune_cell0.94205448
94MP0000716_abnormal_immune_system0.93921892
95MP0009785_altered_susceptibility_to0.93486714
96MP0002938_white_spotting0.93133333
97MP0002837_dystrophic_cardiac_calcinosis0.92805207
98MP0003646_muscle_fatigue0.92481241
99MP0010030_abnormal_orbit_morphology0.92400862
100MP0003123_paternal_imprinting0.91410648
101MP0002429_abnormal_blood_cell0.90515496
102MP0005397_hematopoietic_system_phenotyp0.90355942
103MP0001545_abnormal_hematopoietic_system0.90355942
104MP0001730_embryonic_growth_arrest0.89673585
105MP0003755_abnormal_palate_morphology0.88268420
106MP0006276_abnormal_autonomic_nervous0.87738010
107MP0002697_abnormal_eye_size0.87554766
108MP0002075_abnormal_coat/hair_pigmentati0.87161699
109MP0002736_abnormal_nociception_after0.86719186
110MP0000049_abnormal_middle_ear0.86299821
111MP0002085_abnormal_embryonic_tissue0.85494189
112MP0004142_abnormal_muscle_tone0.84818434
113MP0008995_early_reproductive_senescence0.84063427
114MP0003119_abnormal_digestive_system0.83973635
115MP0001764_abnormal_homeostasis0.83496969
116MP0005187_abnormal_penis_morphology0.82622378
117MP0002723_abnormal_immune_serum0.82547043
118MP0001697_abnormal_embryo_size0.81762291
119MP0002148_abnormal_hypersensitivity_rea0.81605146
120MP0002163_abnormal_gland_morphology0.81201212
121MP0004197_abnormal_fetal_growth/weight/0.80702480
122MP0002177_abnormal_outer_ear0.79325500
123MP0003984_embryonic_growth_retardation0.79129254
124MP0009046_muscle_twitch0.78295825
125MP0005171_absent_coat_pigmentation0.77912959
126MP0005377_hearing/vestibular/ear_phenot0.77355272
127MP0003878_abnormal_ear_physiology0.77355272
128MP0003567_abnormal_fetal_cardiomyocyte0.77324182
129MP0002751_abnormal_autonomic_nervous0.77187994
130MP0001286_abnormal_eye_development0.76768384
131MP0002006_tumorigenesis0.76508768
132MP0002088_abnormal_embryonic_growth/wei0.74775616
133MP0002080_prenatal_lethality0.74164739
134MP0000371_diluted_coat_color0.73818841
135MP0001486_abnormal_startle_reflex0.73685177
136MP0004381_abnormal_hair_follicle0.73382963
137MP0003943_abnormal_hepatobiliary_system0.73350762
138MP0003122_maternal_imprinting0.72827241
139MP0000858_altered_metastatic_potential0.72185529
140MP0003861_abnormal_nervous_system0.71584418
141MP0000678_abnormal_parathyroid_gland0.71336107
142MP0003221_abnormal_cardiomyocyte_apopto0.71295789
143MP0005499_abnormal_olfactory_system0.70289131
144MP0005394_taste/olfaction_phenotype0.70289131
145MP0003937_abnormal_limbs/digits/tail_de0.69957180
146MP0003718_maternal_effect0.69941506
147MP0002084_abnormal_developmental_patter0.68703033

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.65332041
2Chromsome breakage (HP:0040012)4.59603878
3Birth length less than 3rd percentile (HP:0003561)3.63732817
4Abnormality of the labia minora (HP:0012880)3.48003209
5Abnormality of the preputium (HP:0100587)3.26055834
6Abnormality of chromosome stability (HP:0003220)3.26025163
7Aplasia/Hypoplasia of the uvula (HP:0010293)3.22445373
8Meckel diverticulum (HP:0002245)3.20351660
9Abnormality of the ileum (HP:0001549)3.03747002
10Ectopic kidney (HP:0000086)3.03414119
11Abnormality of the fovea (HP:0000493)2.87017782
12Abnormality of the renal collecting system (HP:0004742)2.73704012
13Duplicated collecting system (HP:0000081)2.68565091
14Aplasia/Hypoplasia of the macula (HP:0008059)2.63235512
15Type I transferrin isoform profile (HP:0003642)2.62134834
16Clubbing of toes (HP:0100760)2.59833269
17Colon cancer (HP:0003003)2.56974234
18True hermaphroditism (HP:0010459)2.56866996
19Patchy hypopigmentation of hair (HP:0011365)2.49543794
20Pancreatic fibrosis (HP:0100732)2.46902065
21Aplastic anemia (HP:0001915)2.46213240
22Reticulocytopenia (HP:0001896)2.45837425
23Pancreatic cysts (HP:0001737)2.45834333
24Volvulus (HP:0002580)2.45200549
25Medulloblastoma (HP:0002885)2.44799632
26Medial flaring of the eyebrow (HP:0010747)2.41074221
27* Sloping forehead (HP:0000340)2.40592568
28* Myelodysplasia (HP:0002863)2.40212644
29Chronic hepatic failure (HP:0100626)2.39731060
30* Small intestinal stenosis (HP:0012848)2.39577027
31* Duodenal stenosis (HP:0100867)2.39577027
32Impulsivity (HP:0100710)2.38646240
33Astigmatism (HP:0000483)2.38498679
34Aplasia/Hypoplasia affecting the retina (HP:0008061)2.38229879
35Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.37684018
36White forelock (HP:0002211)2.37058406
37Patellar aplasia (HP:0006443)2.36440466
38Absent/shortened dynein arms (HP:0200106)2.33505008
39Dynein arm defect of respiratory motile cilia (HP:0012255)2.33505008
4011 pairs of ribs (HP:0000878)2.32273568
41Congenital stationary night blindness (HP:0007642)2.31331880
42Nephrogenic diabetes insipidus (HP:0009806)2.27923645
43Gait imbalance (HP:0002141)2.27861894
44Congenital primary aphakia (HP:0007707)2.26223906
45Abnormality of DNA repair (HP:0003254)2.25684465
46Bone marrow hypocellularity (HP:0005528)2.23744807
47Abnormal respiratory epithelium morphology (HP:0012253)2.23032458
48Abnormal respiratory motile cilium morphology (HP:0005938)2.23032458
49Abnormality of the carotid arteries (HP:0005344)2.20403296
50Abnormality of midbrain morphology (HP:0002418)2.19767994
51Molar tooth sign on MRI (HP:0002419)2.19767994
52Supernumerary spleens (HP:0009799)2.19696243
53Aplasia/Hypoplasia of the patella (HP:0006498)2.19692815
54Abnormality of the anterior horn cell (HP:0006802)2.18927138
55Degeneration of anterior horn cells (HP:0002398)2.18927138
56Type 2 muscle fiber atrophy (HP:0003554)2.16785188
57Optic nerve coloboma (HP:0000588)2.15914645
58Facial cleft (HP:0002006)2.15629804
59Cortical dysplasia (HP:0002539)2.14760080
60Abnormal auditory evoked potentials (HP:0006958)2.14100725
61Median cleft lip (HP:0000161)2.13029927
62Prostate neoplasm (HP:0100787)2.12336149
63Preaxial hand polydactyly (HP:0001177)2.11929363
64Bifid tongue (HP:0010297)2.10604953
65* Abnormal lung lobation (HP:0002101)2.08191728
66Lymphoma (HP:0002665)2.04506759
67Nephronophthisis (HP:0000090)2.04400589
68Aqueductal stenosis (HP:0002410)2.04125288
69Breast hypoplasia (HP:0003187)2.03612909
70Abnormality of the renal cortex (HP:0011035)2.03285699
71Agnosia (HP:0010524)2.03174001
72Genital tract atresia (HP:0001827)2.02498081
73IgM deficiency (HP:0002850)2.01861514
74Ependymoma (HP:0002888)1.98899953
75Tubulointerstitial nephritis (HP:0001970)1.98191098
76Neoplasm of the adrenal cortex (HP:0100641)1.98164243
77Abnormality of the prostate (HP:0008775)1.98161755
78Abnormal spermatogenesis (HP:0008669)1.98054814
79Blue irides (HP:0000635)1.97006357
80Absent thumb (HP:0009777)1.96592635
81Hyperglycinemia (HP:0002154)1.96431546
82Aplasia/Hypoplasia of the tibia (HP:0005772)1.95355014
83Aplasia/Hypoplasia of the sternum (HP:0006714)1.94863951
84Renal cortical cysts (HP:0000803)1.94731836
85* Intestinal atresia (HP:0011100)1.94341025
86Methylmalonic acidemia (HP:0002912)1.93343738
87Vaginal atresia (HP:0000148)1.92332112
88Premature graying of hair (HP:0002216)1.90968926
89Muscle fiber atrophy (HP:0100295)1.90951266
90Postaxial hand polydactyly (HP:0001162)1.90888215
91Glioma (HP:0009733)1.90473713
92Selective tooth agenesis (HP:0001592)1.89726537
93Rhabdomyosarcoma (HP:0002859)1.89511295
94Reduced antithrombin III activity (HP:0001976)1.88288825
95* Abnormality of the duodenum (HP:0002246)1.88087830
96Postaxial foot polydactyly (HP:0001830)1.86656223
97Long clavicles (HP:0000890)1.86589713
98Lip pit (HP:0100267)1.85319771
99Abnormality of the astrocytes (HP:0100707)1.84517256
100Astrocytoma (HP:0009592)1.84517256
101Abnormality of the renal medulla (HP:0100957)1.84115691
102Short tibia (HP:0005736)1.82613141
103Oligodactyly (hands) (HP:0001180)1.82319227
104Optic neuritis (HP:0100653)1.81045528
105Retrobulbar optic neuritis (HP:0100654)1.81045528
106Poor coordination (HP:0002370)1.77830289
107Abnormal number of erythroid precursors (HP:0012131)1.77803430
108Small hand (HP:0200055)1.77720115
109Acute necrotizing encephalopathy (HP:0006965)1.77535959
110Short thumb (HP:0009778)1.76871231
111Aplasia/Hypoplasia of the tongue (HP:0010295)1.76106635
112* Nephroblastoma (Wilms tumor) (HP:0002667)1.75279612
113Triphalangeal thumb (HP:0001199)1.74240436
114Abnormality of alanine metabolism (HP:0010916)1.74084476
115Hyperalaninemia (HP:0003348)1.74084476
116Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.74084476
117Aganglionic megacolon (HP:0002251)1.74003029
118Deep philtrum (HP:0002002)1.73910615
119Acute encephalopathy (HP:0006846)1.73909759
120Gaze-evoked nystagmus (HP:0000640)1.73718435
121Abnormal hair whorl (HP:0010721)1.73139553
122Tracheoesophageal fistula (HP:0002575)1.73038501
123Increased hepatocellular lipid droplets (HP:0006565)1.73018606
124Fibular hypoplasia (HP:0003038)1.72417463
125Absent radius (HP:0003974)1.70924598
126Increased CSF lactate (HP:0002490)1.70800048
127Abnormality of the fingertips (HP:0001211)1.70595397
128* Embryonal renal neoplasm (HP:0011794)1.70479679
129Cleft eyelid (HP:0000625)1.70264319
130Syringomyelia (HP:0003396)1.70214447
131Spinal cord lesions (HP:0100561)1.70214447
132Freckling (HP:0001480)1.69929649
133Abnormal protein N-linked glycosylation (HP:0012347)1.68898279
134Abnormal protein glycosylation (HP:0012346)1.68898279
135Abnormal glycosylation (HP:0012345)1.68898279
136Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.68898279
137Albinism (HP:0001022)1.68454456
138Short middle phalanx of the 5th finger (HP:0004220)1.67685156
139Pulmonary fibrosis (HP:0002206)1.67344700
140Recurrent sinusitis (HP:0011108)1.66356527
141Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.66161086
142Hypoplasia of the fovea (HP:0007750)1.66022858
143Aplasia/Hypoplasia of the fovea (HP:0008060)1.66022858
144Optic nerve hypoplasia (HP:0000609)1.65465964
145Progressive macrocephaly (HP:0004481)1.65241287
146Mediastinal lymphadenopathy (HP:0100721)1.65230892
147Broad foot (HP:0001769)1.64168694
148Recurrent pneumonia (HP:0006532)1.64007231
149Hepatoblastoma (HP:0002884)1.63906682
150Absent forearm bone (HP:0003953)1.63716942
151Aplasia involving forearm bones (HP:0009822)1.63716942
152Anencephaly (HP:0002323)1.63506891
153IgG deficiency (HP:0004315)1.62179031
154Oligohydramnios (HP:0001562)1.61779628
155Acute myeloid leukemia (HP:0004808)1.61068556
156Cystic liver disease (HP:0006706)1.60564953
157Abnormality of the columella (HP:0009929)1.59618822
158Abnormality of B cell number (HP:0010975)1.59500348
159B lymphocytopenia (HP:0010976)1.59500348

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK3.72190865
2CDC73.42358497
3SRPK12.79300393
4PLK42.76652666
5FRK2.73912081
6BUB12.58385315
7WEE12.56844699
8WNK32.43399115
9MAP3K42.42113752
10MAP4K22.40813741
11TRIM282.36194587
12MKNK12.22467915
13VRK12.22455967
14BCR2.20961433
15MKNK22.18327218
16TTK2.17342369
17BRSK22.06074228
18TXK2.01358228
19LATS11.97582559
20CDK121.87619245
21ATR1.86465587
22IRAK41.84307341
23PASK1.82241275
24NEK11.78208628
25STK161.76880804
26YES11.75587826
27EIF2AK31.74985313
28NEK21.70948090
29NUAK11.69743114
30PLK31.67763472
31PLK11.67643009
32EIF2AK21.65556667
33EIF2AK11.62661134
34CHEK21.61055831
35CASK1.57889924
36BRD41.51020048
37AURKB1.43386870
38TLK11.40232115
39CDK71.39514754
40CCNB11.36684679
41TNIK1.30477380
42PLK21.27814239
43PRPF4B1.27528088
44CLK11.26763274
45IRAK31.26006856
46TEC1.25482843
47CDK31.25182464
48DYRK31.23277893
49MAP3K141.21508417
50MARK11.20233473
51NLK1.17215340
52FGFR21.14115008
53TAF11.13252497
54PIM11.08310708
55CDK81.07815234
56CSNK1G21.06636981
57CHEK11.06198322
58PNCK1.06095539
59ACVR1B1.05509879
60ATM1.05313033
61CSNK1G31.03847896
62STK41.03757619
63SIK31.01893295
64RPS6KA41.00544504
65ERBB30.98648942
66CSNK1G10.97896732
67BRSK10.95902678
68MINK10.94324388
69TSSK60.93608049
70CSNK1A1L0.91101774
71INSRR0.90051958
72VRK20.89803082
73AKT30.88913610
74CDK190.85003642
75BMPR20.84250185
76CHUK0.82749899
77CDK40.82507717
78MAP4K10.81943807
79RPS6KB20.81120018
80BMPR1B0.80383464
81STK38L0.80287408
82PIM20.79711152
83TAOK20.78769669
84BTK0.76635582
85IKBKB0.75735557
86NME20.73549168
87AURKA0.72124217
88PDK20.71284003
89MARK30.70386022
90RPS6KA50.68623305
91CDK20.67438806
92CDK60.66793629
93STK390.66704537
94IRAK20.66011475
95OXSR10.63654780
96CSNK2A10.63413102
97CDK10.63184045
98MELK0.61670681
99MAP2K60.60770544
100DYRK1A0.59921671
101EPHA30.59103172
102ADRBK20.59055676
103BRAF0.58139275
104UHMK10.57773552
105NEK60.56748679
106FLT30.55621529
107MAP2K40.54091820
108TGFBR10.52896633
109KIT0.52576495
110WNK40.51815853
111PBK0.51519783
112STK30.51293814
113EPHA20.50168448
114MAP2K70.49822623
115PDK40.47471392
116PDK30.47471392
117PRKCI0.47379454
118CDK90.47212062
119IKBKE0.47170244
120GRK10.45787216
121KSR10.45738139
122NME10.45185973
123RPS6KB10.45085209
124NEK90.44965961
125CSNK2A20.44819979
126ZAP700.44810238
127PRKCG0.44382121
128CSNK1D0.44202066
129DYRK20.43677225
130IRAK10.43535386
131STK100.43227528
132PAK30.42664377
133FGFR10.41114120
134NTRK30.40907662
135LYN0.40530395
136MAPK130.40136097
137MAP3K60.39408708
138STK240.38881954
139EPHA40.37530283
140CSNK1E0.36357492
141MST40.36210672
142PRKCE0.35081825
143BCKDK0.32643172
144PRKCH0.29947140
145PINK10.29879016
146PRKDC0.28382261

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.37690349
2Mismatch repair_Homo sapiens_hsa034304.11597494
3Homologous recombination_Homo sapiens_hsa034403.47280348
4Fanconi anemia pathway_Homo sapiens_hsa034603.12101597
5Base excision repair_Homo sapiens_hsa034103.09393478
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.88441466
7Spliceosome_Homo sapiens_hsa030402.77280721
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.75190716
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.66435632
10Nucleotide excision repair_Homo sapiens_hsa034202.66198445
11RNA polymerase_Homo sapiens_hsa030202.57107561
12Cell cycle_Homo sapiens_hsa041102.54386503
13Non-homologous end-joining_Homo sapiens_hsa034502.50093824
14Basal transcription factors_Homo sapiens_hsa030222.45394478
15RNA transport_Homo sapiens_hsa030132.28502239
16Pyrimidine metabolism_Homo sapiens_hsa002402.13712261
17RNA degradation_Homo sapiens_hsa030182.10447973
18One carbon pool by folate_Homo sapiens_hsa006702.08021639
19Propanoate metabolism_Homo sapiens_hsa006402.05000854
20Proteasome_Homo sapiens_hsa030502.00835825
21Ribosome_Homo sapiens_hsa030101.86375353
22mRNA surveillance pathway_Homo sapiens_hsa030151.73883015
23Butanoate metabolism_Homo sapiens_hsa006501.68482538
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.62958120
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.61084192
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.56736559
27p53 signaling pathway_Homo sapiens_hsa041151.49672872
28Oxidative phosphorylation_Homo sapiens_hsa001901.49083153
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.45503809
30Primary immunodeficiency_Homo sapiens_hsa053401.44437231
31Purine metabolism_Homo sapiens_hsa002301.42778216
32Parkinsons disease_Homo sapiens_hsa050121.42417131
33Herpes simplex infection_Homo sapiens_hsa051681.41058373
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.30434191
35Steroid biosynthesis_Homo sapiens_hsa001001.27967709
36Systemic lupus erythematosus_Homo sapiens_hsa053221.24863611
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.23303970
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20530085
39Protein export_Homo sapiens_hsa030601.18363996
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.18069943
41Epstein-Barr virus infection_Homo sapiens_hsa051691.13193551
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.13092623
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.12137706
44Nicotine addiction_Homo sapiens_hsa050331.09866889
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04599106
46Measles_Homo sapiens_hsa051621.04315811
47Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97970569
48Fatty acid elongation_Homo sapiens_hsa000620.97960400
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96986807
50Antigen processing and presentation_Homo sapiens_hsa046120.96441343
51Autoimmune thyroid disease_Homo sapiens_hsa053200.94640066
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.94128046
53Allograft rejection_Homo sapiens_hsa053300.89875167
54Pyruvate metabolism_Homo sapiens_hsa006200.88816584
55Hematopoietic cell lineage_Homo sapiens_hsa046400.86878363
56Viral carcinogenesis_Homo sapiens_hsa052030.85187726
57Peroxisome_Homo sapiens_hsa041460.84612396
58Graft-versus-host disease_Homo sapiens_hsa053320.83780430
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.79346573
60Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.79109182
61HTLV-I infection_Homo sapiens_hsa051660.78696785
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76363278
63Legionellosis_Homo sapiens_hsa051340.73369532
64N-Glycan biosynthesis_Homo sapiens_hsa005100.72687757
65Taste transduction_Homo sapiens_hsa047420.72098309
66Maturity onset diabetes of the young_Homo sapiens_hsa049500.69355121
67Influenza A_Homo sapiens_hsa051640.68147660
68Arachidonic acid metabolism_Homo sapiens_hsa005900.67985978
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67017527
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65515174
71Lysine degradation_Homo sapiens_hsa003100.65405813
72Alzheimers disease_Homo sapiens_hsa050100.64534540
73Nitrogen metabolism_Homo sapiens_hsa009100.63355156
74Fatty acid metabolism_Homo sapiens_hsa012120.62360282
75Regulation of autophagy_Homo sapiens_hsa041400.61493533
76Metabolic pathways_Homo sapiens_hsa011000.60590773
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58822047
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58013883
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57417644
80Oocyte meiosis_Homo sapiens_hsa041140.56961119
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56500868
82Hepatitis B_Homo sapiens_hsa051610.55980064
83Apoptosis_Homo sapiens_hsa042100.55511698
84Olfactory transduction_Homo sapiens_hsa047400.55321933
85Folate biosynthesis_Homo sapiens_hsa007900.53953048
86Asthma_Homo sapiens_hsa053100.53505646
87Biosynthesis of amino acids_Homo sapiens_hsa012300.53179825
88GABAergic synapse_Homo sapiens_hsa047270.52770715
89Leishmaniasis_Homo sapiens_hsa051400.52432127
90Hedgehog signaling pathway_Homo sapiens_hsa043400.52164413
91MicroRNAs in cancer_Homo sapiens_hsa052060.52055854
92Tryptophan metabolism_Homo sapiens_hsa003800.52029070
93Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.51929411
94Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51431401
952-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49834137
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48538262
97Morphine addiction_Homo sapiens_hsa050320.47814327
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47747499
99Cyanoamino acid metabolism_Homo sapiens_hsa004600.47262672
100Small cell lung cancer_Homo sapiens_hsa052220.47040472
101Jak-STAT signaling pathway_Homo sapiens_hsa046300.46198536
102Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46172419
103Collecting duct acid secretion_Homo sapiens_hsa049660.44468664
104Shigellosis_Homo sapiens_hsa051310.44199385
105Notch signaling pathway_Homo sapiens_hsa043300.43754828
106Basal cell carcinoma_Homo sapiens_hsa052170.43323114
107Alcoholism_Homo sapiens_hsa050340.42608169
108beta-Alanine metabolism_Homo sapiens_hsa004100.42103720
109Fatty acid degradation_Homo sapiens_hsa000710.41916076
110Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41504952
111Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.41424230
112Caffeine metabolism_Homo sapiens_hsa002320.40820805
113Toll-like receptor signaling pathway_Homo sapiens_hsa046200.40114938
114Carbon metabolism_Homo sapiens_hsa012000.39960949
115Type I diabetes mellitus_Homo sapiens_hsa049400.39782662
116Ether lipid metabolism_Homo sapiens_hsa005650.39006836
117Colorectal cancer_Homo sapiens_hsa052100.37158075
118Vitamin B6 metabolism_Homo sapiens_hsa007500.36633119
119Other glycan degradation_Homo sapiens_hsa005110.36553738
120Phototransduction_Homo sapiens_hsa047440.36162910
121Thyroid cancer_Homo sapiens_hsa052160.35748802
122SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35132992
123Retinol metabolism_Homo sapiens_hsa008300.34145909
124Viral myocarditis_Homo sapiens_hsa054160.33995561
125Primary bile acid biosynthesis_Homo sapiens_hsa001200.33974785
126Prostate cancer_Homo sapiens_hsa052150.33918478
127Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32946903
128T cell receptor signaling pathway_Homo sapiens_hsa046600.32891984
129Selenocompound metabolism_Homo sapiens_hsa004500.32808249
130TGF-beta signaling pathway_Homo sapiens_hsa043500.31988370
131Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.31531945
132Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30923593
133Tyrosine metabolism_Homo sapiens_hsa003500.30464621
134Dopaminergic synapse_Homo sapiens_hsa047280.30395131
135Huntingtons disease_Homo sapiens_hsa050160.29028272
136B cell receptor signaling pathway_Homo sapiens_hsa046620.28874376
137Chemical carcinogenesis_Homo sapiens_hsa052040.27916167
138alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27613975
139Pathways in cancer_Homo sapiens_hsa052000.27549708
140Wnt signaling pathway_Homo sapiens_hsa043100.26877079
141Linoleic acid metabolism_Homo sapiens_hsa005910.25659957
142Drug metabolism - other enzymes_Homo sapiens_hsa009830.25294072
143TNF signaling pathway_Homo sapiens_hsa046680.24479982
144Toxoplasmosis_Homo sapiens_hsa051450.24149439
145Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.24023642
146Adherens junction_Homo sapiens_hsa045200.23264660
147FoxO signaling pathway_Homo sapiens_hsa040680.22633129
148Malaria_Homo sapiens_hsa051440.22226056
149Glycosaminoglycan degradation_Homo sapiens_hsa005310.22002258
150Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.21655582
151Sphingolipid metabolism_Homo sapiens_hsa006000.20975194
152Pentose phosphate pathway_Homo sapiens_hsa000300.18680941
153Circadian rhythm_Homo sapiens_hsa047100.18089254
154Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.17057182
155Hippo signaling pathway_Homo sapiens_hsa043900.16340954
156Glutathione metabolism_Homo sapiens_hsa004800.16285160

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