CEP63

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with six coiled-coil domains. The protein is localized to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. Several alternatively spliced transcript variants have been found, but their biological validity has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane fusion (GO:0045026)9.84452803
2acrosome reaction (GO:0007340)9.71917089
3binding of sperm to zona pellucida (GO:0007339)9.68829743
4epithelial cilium movement (GO:0003351)9.64800273
5piRNA metabolic process (GO:0034587)9.60964059
6cell-cell recognition (GO:0009988)9.59962848
7motile cilium assembly (GO:0044458)9.23508532
8spermatid development (GO:0007286)8.83649031
9reproduction (GO:0000003)8.76617872
10male meiosis (GO:0007140)8.42719558
11cilium movement (GO:0003341)8.29662550
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.12997853
13synaptonemal complex organization (GO:0070193)7.82647877
14regulation of cilium movement (GO:0003352)7.73945724
15synaptonemal complex assembly (GO:0007130)7.53537328
16single fertilization (GO:0007338)7.16857271
17sperm capacitation (GO:0048240)6.29876384
18DNA methylation involved in gamete generation (GO:0043046)6.24847004
19fertilization (GO:0009566)6.12275052
20male meiosis I (GO:0007141)6.03526632
21negative regulation of inclusion body assembly (GO:0090084)5.74801621
22spermatogenesis (GO:0007283)5.68876293
23male gamete generation (GO:0048232)5.67673042
24microtubule depolymerization (GO:0007019)5.47501697
25chromosome organization involved in meiosis (GO:0070192)5.44142294
26gamete generation (GO:0007276)5.22689484
27meiotic nuclear division (GO:0007126)5.16465815
28germ cell development (GO:0007281)5.10610005
29ventricular system development (GO:0021591)5.08030062
30cellular process involved in reproduction in multicellular organism (GO:0022412)5.03591706
31meiosis I (GO:0007127)4.94112946
32seminiferous tubule development (GO:0072520)4.92741068
33regulation of inclusion body assembly (GO:0090083)4.84352154
34meiotic cell cycle (GO:0051321)4.66173331
35organic cation transport (GO:0015695)4.66038450
36cell recognition (GO:0008037)4.47272204
37regulation of microtubule-based movement (GO:0060632)4.46500136
38calcium ion-dependent exocytosis (GO:0017156)4.41326409
39monoubiquitinated protein deubiquitination (GO:0035520)4.34073945
40microtubule severing (GO:0051013)4.20698540
41protein localization to cilium (GO:0061512)4.19409714
42left/right pattern formation (GO:0060972)4.10172199
43intraciliary transport (GO:0042073)4.09673728
44multicellular organismal reproductive process (GO:0048609)4.08026892
45spermatid nucleus differentiation (GO:0007289)4.04400850
46protein polyglutamylation (GO:0018095)3.74994033
47microglial cell activation (GO:0001774)3.72934413
48axoneme assembly (GO:0035082)3.65671007
49genitalia morphogenesis (GO:0035112)3.62996008
50gene silencing by RNA (GO:0031047)3.58021122
51regulation of B cell receptor signaling pathway (GO:0050855)3.57082235
52chaperone-mediated protein complex assembly (GO:0051131)3.55520239
53negative regulation of cAMP-mediated signaling (GO:0043951)3.51417158
54regulation of meiosis I (GO:0060631)3.42970436
55meiotic cell cycle process (GO:1903046)3.41620667
56DNA deamination (GO:0045006)3.41404031
57synapsis (GO:0007129)3.41249244
58regulation of centriole replication (GO:0046599)3.35521720
59regulation of spindle checkpoint (GO:0090231)3.35385792
60multicellular organismal development (GO:0007275)3.31176337
61single strand break repair (GO:0000012)3.31139304
62glycerol ether metabolic process (GO:0006662)3.29650100
63positive regulation of meiosis (GO:0045836)3.27788801
64cilium organization (GO:0044782)3.25243326
65GTP biosynthetic process (GO:0006183)3.21907815
66microtubule-based movement (GO:0007018)3.18353440
67negative regulation of mast cell activation (GO:0033004)3.17860013
68DNA packaging (GO:0006323)3.13460324
69neutrophil mediated immunity (GO:0002446)3.12395921
70respiratory chain complex IV assembly (GO:0008535)3.12180388
71cilium assembly (GO:0042384)3.11159298
72mitotic sister chromatid cohesion (GO:0007064)3.09831750
73neural tube formation (GO:0001841)3.09756126
74chromosome condensation (GO:0030261)3.09383684
75antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.08442828
76protein refolding (GO:0042026)3.06299930
77regulation of interleukin-6 biosynthetic process (GO:0045408)3.03985858
78nucleoside diphosphate phosphorylation (GO:0006165)3.03590654
79behavioral response to nicotine (GO:0035095)3.03496780
80positive regulation of meiotic cell cycle (GO:0051446)3.01450890
81negative regulation of organelle assembly (GO:1902116)3.01044362
82ether metabolic process (GO:0018904)3.00712371
83cilium morphogenesis (GO:0060271)2.99701398
84nuclear pore complex assembly (GO:0051292)2.98894027
85microtubule polymerization or depolymerization (GO:0031109)2.98459710
86cellular component assembly involved in morphogenesis (GO:0010927)2.98226997
87protein K11-linked deubiquitination (GO:0035871)2.97113054
88detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.96753030
89sulfation (GO:0051923)2.94509347
90positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.91858520
91amino-acid betaine transport (GO:0015838)2.90866926
92carnitine transport (GO:0015879)2.90866926
93carnitine transmembrane transport (GO:1902603)2.90230705
94nucleus organization (GO:0006997)2.89618106
95UTP biosynthetic process (GO:0006228)2.84601125
96negative regulation of interleukin-1 production (GO:0032692)2.80561530
97alditol metabolic process (GO:0019400)2.78832097
98lactate metabolic process (GO:0006089)2.75631347
99regulation of mast cell activation (GO:0033003)2.74919268
100negative regulation of cell killing (GO:0031342)2.72834333
101negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.72834333
102positive regulation of mast cell activation (GO:0033005)2.71998928
103establishment of protein localization to Golgi (GO:0072600)2.71418199
104cellular response to interleukin-15 (GO:0071350)2.70051460
105sister chromatid cohesion (GO:0007062)2.68854287
106histone exchange (GO:0043486)2.68386404
107negative regulation of interleukin-1 beta production (GO:0032691)2.67556939
108gene silencing (GO:0016458)2.67229834
109neutrophil activation involved in immune response (GO:0002283)2.64512733
110detection of light stimulus involved in visual perception (GO:0050908)2.63877340
111detection of light stimulus involved in sensory perception (GO:0050962)2.63877340
112neutrophil activation (GO:0042119)2.63810891
113polyol catabolic process (GO:0046174)2.62083470
114sequestering of actin monomers (GO:0042989)2.58310969
115myeloid leukocyte mediated immunity (GO:0002444)2.56966746
116L-fucose catabolic process (GO:0042355)2.55485771
117fucose catabolic process (GO:0019317)2.55485771
118L-fucose metabolic process (GO:0042354)2.55485771
119reciprocal meiotic recombination (GO:0007131)2.54042029
120reciprocal DNA recombination (GO:0035825)2.54042029
121regulation of germinal center formation (GO:0002634)2.53991554
122protein targeting to Golgi (GO:0000042)2.53973181
123positive regulation of mast cell degranulation (GO:0043306)2.52441976
124positive regulation of mast cell activation involved in immune response (GO:0033008)2.52441976
125mast cell degranulation (GO:0043303)2.51508138
126mast cell activation involved in immune response (GO:0002279)2.51508138
127UTP metabolic process (GO:0046051)2.50208945
128guanosine-containing compound biosynthetic process (GO:1901070)2.49661241
129detection of molecule of bacterial origin (GO:0032490)2.48227268
130indolalkylamine metabolic process (GO:0006586)2.47803927
131cytochrome complex assembly (GO:0017004)2.47675944
132DNA methylation (GO:0006306)2.47651303
133DNA alkylation (GO:0006305)2.47651303
134interkinetic nuclear migration (GO:0022027)2.44666272
135mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.44462539
136mitochondrial respiratory chain complex I assembly (GO:0032981)2.44462539
137NADH dehydrogenase complex assembly (GO:0010257)2.44462539
138activated T cell proliferation (GO:0050798)2.44174976
139positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.43437265
140glycerol metabolic process (GO:0006071)2.43212457
141positive regulation of gamma-delta T cell activation (GO:0046645)2.40749144
142DNA demethylation (GO:0080111)2.38848790
143regulation of protein glycosylation (GO:0060049)2.38381166
144mast cell activation (GO:0045576)2.38304978
145modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.38224639
146positive regulation by organism of defense response of other organism involved in symbiotic interact2.38224639
147modulation by symbiont of host immune response (GO:0052553)2.38224639
148positive regulation by symbiont of host defense response (GO:0052509)2.38224639
149modulation by symbiont of host defense response (GO:0052031)2.38224639
150modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.38224639
151platelet dense granule organization (GO:0060155)2.36093748
152adaptation of signaling pathway (GO:0023058)2.35170194
153adenosine metabolic process (GO:0046085)2.35169226
154positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.34833060
155response to pheromone (GO:0019236)2.33672951
156macrophage activation (GO:0042116)2.32682402
157meiotic chromosome segregation (GO:0045132)2.32082123
158protein prenylation (GO:0018342)2.31269459
159prenylation (GO:0097354)2.31269459
160positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.27368895
161negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.27071369
162tryptophan metabolic process (GO:0006568)2.26601379
163histone mRNA catabolic process (GO:0071044)2.26147445
164retinal cone cell development (GO:0046549)2.26103987
165retrograde transport, vesicle recycling within Golgi (GO:0000301)2.26043366
166protein complex biogenesis (GO:0070271)2.25725143
167cytidine metabolic process (GO:0046087)2.24615667
168cytidine catabolic process (GO:0006216)2.24615667
169cytidine deamination (GO:0009972)2.24615667
170cellular extravasation (GO:0045123)2.24016831
171neuron cell-cell adhesion (GO:0007158)2.23141406
172negative regulation of T cell mediated immunity (GO:0002710)2.23129397
173purinergic nucleotide receptor signaling pathway (GO:0035590)2.22755979
174regulation of hexokinase activity (GO:1903299)2.21764599
175regulation of glucokinase activity (GO:0033131)2.21764599
176response to interleukin-15 (GO:0070672)2.20495022
177cilium or flagellum-dependent cell motility (GO:0001539)13.9484615
178fusion of sperm to egg plasma membrane (GO:0007342)13.0478043
179sperm motility (GO:0030317)11.5903141
180cell wall macromolecule catabolic process (GO:0016998)10.9485364
181cell wall macromolecule metabolic process (GO:0044036)10.9485364
182sperm-egg recognition (GO:0035036)10.6986160
183multicellular organism reproduction (GO:0032504)10.6728178
184acrosome assembly (GO:0001675)10.4017062
185axonemal dynein complex assembly (GO:0070286)10.3919494

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.52389087
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.21011776
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.64397930
4IGF1R_20145208_ChIP-Seq_DFB_Human2.74535466
5FLI1_27457419_Chip-Seq_LIVER_Mouse2.65184193
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.58671187
7GBX2_23144817_ChIP-Seq_PC3_Human2.51808879
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.48714390
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.47147786
10* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.33587271
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.29799973
12FUS_26573619_Chip-Seq_HEK293_Human2.19304100
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.16870242
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.16489199
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.05688406
16P300_19829295_ChIP-Seq_ESCs_Human2.00668899
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.0460084
18ZNF274_21170338_ChIP-Seq_K562_Hela1.95382352
19EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.91196342
20ER_23166858_ChIP-Seq_MCF-7_Human1.87206198
21GATA1_26923725_Chip-Seq_HPCs_Mouse1.82917661
22VDR_22108803_ChIP-Seq_LS180_Human1.77557418
23STAT6_21828071_ChIP-Seq_BEAS2B_Human1.76588988
24EWS_26573619_Chip-Seq_HEK293_Human1.75411353
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.72677426
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70206935
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.69435163
28KAP1_22055183_ChIP-Seq_ESCs_Mouse1.68065578
29UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.68041097
30PCGF2_27294783_Chip-Seq_NPCs_Mouse1.66329564
31NFE2_27457419_Chip-Seq_LIVER_Mouse1.62022808
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60702686
33ELK4_26923725_Chip-Seq_MESODERM_Mouse1.59894471
34TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.59807017
35WDR5_24793694_ChIP-Seq_LNCAP_Human1.59691329
36FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.57673649
37STAT1_17558387_ChIP-Seq_HELA_Human1.54865254
38SMAD4_21799915_ChIP-Seq_A2780_Human1.50935135
39SUZ12_27294783_Chip-Seq_NPCs_Mouse1.50378945
40BCAT_22108803_ChIP-Seq_LS180_Human1.50188494
41STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.49918087
42KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.49729081
43RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49100487
44TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.48376605
45TCF4_23295773_ChIP-Seq_U87_Human1.48265371
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.47078941
47MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46078240
48RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.45928973
49STAT3_23295773_ChIP-Seq_U87_Human1.45072221
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43338269
51TAL1_26923725_Chip-Seq_HPCs_Mouse1.43135676
52NANOG_19829295_ChIP-Seq_ESCs_Human1.41861659
53SOX2_19829295_ChIP-Seq_ESCs_Human1.41861659
54AR_25329375_ChIP-Seq_VCAP_Human1.40667458
55GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.40644076
56FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40633282
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.37424776
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37270360
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36193493
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35581287
61GATA3_21867929_ChIP-Seq_CD8_Mouse1.34941166
62TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33961044
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33327136
64CBX2_27304074_Chip-Seq_ESCs_Mouse1.32993857
65TP53_22573176_ChIP-Seq_HFKS_Human1.32899282
66IRF8_21731497_ChIP-ChIP_J774_Mouse1.32779200
67PRDM14_20953172_ChIP-Seq_ESCs_Human1.30385430
68SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.30165699
69KDM2B_26808549_Chip-Seq_REH_Human1.29845465
70* SMAD3_21741376_ChIP-Seq_EPCs_Human1.29761528
71* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29638432
72FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28681307
73FOXA1_25329375_ChIP-Seq_VCAP_Human1.28681307
74HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.27515624
75IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.27331486
76* CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.26043918
77MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.25874031
78CRX_20693478_ChIP-Seq_RETINA_Mouse1.24911379
79CBP_20019798_ChIP-Seq_JUKART_Human1.24326695
80IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24326695
81* SOX2_22085726_ChIP-Seq_NPCs_Mouse1.24007165
82RUNX2_22187159_ChIP-Seq_PCA_Human1.23623431
83ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.23026748
84GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22633832
85AR_21572438_ChIP-Seq_LNCaP_Human1.21445173
86GATA3_21867929_ChIP-Seq_TH1_Mouse1.21414433
87FOXA1_21572438_ChIP-Seq_LNCaP_Human1.19039063
88OCT4_18555785_Chip-Seq_ESCs_Mouse1.18579387
89IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.17569865
90EZH2_27294783_Chip-Seq_NPCs_Mouse1.16287895
91NANOG_18555785_Chip-Seq_ESCs_Mouse1.15833054
92EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14679385
93ZFP57_27257070_Chip-Seq_ESCs_Mouse1.14635352
94TCF4_22108803_ChIP-Seq_LS180_Human1.14634718
95FLI1_21867929_ChIP-Seq_TH2_Mouse1.14567598
96* SMAD4_21741376_ChIP-Seq_EPCs_Human1.13777182
97GATA3_26560356_Chip-Seq_TH2_Human1.12747954
98EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12695073
99P300_18555785_Chip-Seq_ESCs_Mouse1.12543672
100CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12521659
101MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11719678
102RUNX_20019798_ChIP-Seq_JUKART_Human1.11063379
103KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10772036
104TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10303645
105POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10303645
106P53_22387025_ChIP-Seq_ESCs_Mouse1.10134898
107LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.10017256
108SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.09887373
109NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09518757
110FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09435663
111IRF1_19129219_ChIP-ChIP_H3396_Human1.09183477
112NOTCH1_21737748_ChIP-Seq_TLL_Human1.09025853
113KLF4_18555785_Chip-Seq_ESCs_Mouse1.07671736
114SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.07581880
115P53_21459846_ChIP-Seq_SAOS-2_Human1.07027282
116ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06101633
117STAT3_18555785_Chip-Seq_ESCs_Mouse1.06043921
118GF1_26923725_Chip-Seq_HPCs_Mouse1.05703735
119FOXH1_21741376_ChIP-Seq_EPCs_Human1.05378270
120CMYC_18555785_Chip-Seq_ESCs_Mouse1.05137023
121YY1_22570637_ChIP-Seq_MALME-3M_Human1.04001215
122OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03932154
123NCOR_22424771_ChIP-Seq_293T_Human1.03642544
124GABP_17652178_ChIP-ChIP_JURKAT_Human1.03466097
125EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.03177526
126AR_20517297_ChIP-Seq_VCAP_Human1.02442877
127ESRRB_18555785_Chip-Seq_ESCs_Mouse1.02136160
128SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00227615
129BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00218464
130REST_21632747_ChIP-Seq_MESCs_Mouse0.99587241
131RUNX1_26923725_Chip-Seq_HPCs_Mouse0.99251066
132PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.96211152
133NFYB_21822215_ChIP-Seq_K562_Human0.95691047
134TAF15_26573619_Chip-Seq_HEK293_Human0.95615616
135TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94359758
136* CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94265353
137PU1_27457419_Chip-Seq_LIVER_Mouse0.93154234
138ESET_19884257_ChIP-Seq_ESCs_Mouse0.91404263
139NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.91044689
140CTBP2_25329375_ChIP-Seq_LNCAP_Human0.90684992
141ZFX_18555785_Chip-Seq_ESCs_Mouse0.90667974
142RUNX1_27457419_Chip-Seq_LIVER_Mouse0.90523770
143RNF2_27304074_Chip-Seq_NSC_Mouse0.90484116
144CTCF_18555785_Chip-Seq_ESCs_Mouse0.89507782
145SOX2_18555785_Chip-Seq_ESCs_Mouse0.89166916
146SOX9_26525672_Chip-Seq_HEART_Mouse0.88990332
147DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88561827
148PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88542228
149SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88373345
150CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88140437
151LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.87958089
152TBL1_22424771_ChIP-Seq_293T_Human0.87831499
153RBPJ_22232070_ChIP-Seq_NCS_Mouse0.87638561
154FLI1_21867929_ChIP-Seq_CD8_Mouse0.87323402
155E2F1_18555785_Chip-Seq_ESCs_Mouse0.87107905
156NMYC_18555785_Chip-Seq_ESCs_Mouse0.86834720
157SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85544265
158PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.85539587
159EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.85316602

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.78140950
2MP0001929_abnormal_gametogenesis5.44100596
3MP0008877_abnormal_DNA_methylation5.36446852
4MP0002210_abnormal_sex_determination3.85154254
5MP0002837_dystrophic_cardiac_calcinosis3.35916586
6MP0001145_abnormal_male_reproductive3.24841521
7MP0003724_increased_susceptibility_to3.23354533
8MP0002653_abnormal_ependyma_morphology3.12020834
9MP0002161_abnormal_fertility/fecundity3.07631586
10MP0000653_abnormal_sex_gland2.82336141
11MP0003787_abnormal_imprinting2.81380595
12MP0008057_abnormal_DNA_replication2.37620828
13MP0003195_calcinosis2.26707781
14MP0001835_abnormal_antigen_presentation2.25290829
15MP0002160_abnormal_reproductive_system2.18976649
16MP0008058_abnormal_DNA_repair2.06820577
17MP0005410_abnormal_fertilization14.2051304
18MP0004147_increased_porphyrin_level1.83682498
19MP0004885_abnormal_endolymph1.81258300
20MP0003136_yellow_coat_color1.79718340
21MP0010094_abnormal_chromosome_stability1.79179247
22MP0004142_abnormal_muscle_tone1.75389636
23MP0005623_abnormal_meninges_morphology1.68840308
24MP0003646_muscle_fatigue1.67970984
25MP0005671_abnormal_response_to1.67466795
26MP0002277_abnormal_respiratory_mucosa1.66696704
27MP0005084_abnormal_gallbladder_morpholo1.60484832
28MP0005670_abnormal_white_adipose1.60307689
29MP0001800_abnormal_humoral_immune1.57785103
30MP0002095_abnormal_skin_pigmentation1.56230240
31MP0001968_abnormal_touch/_nociception1.54697728
32MP0003880_abnormal_central_pattern1.52393473
33MP0009785_altered_susceptibility_to1.40526040
34MP0009764_decreased_sensitivity_to1.36320497
35MP0008872_abnormal_physiological_respon1.34111949
36MP0005646_abnormal_pituitary_gland1.33865497
37MP0001984_abnormal_olfaction1.29179536
38MP0005389_reproductive_system_phenotype1.28586746
39MP0002723_abnormal_immune_serum1.23925532
40MP0002272_abnormal_nervous_system1.23259204
41MP0003786_premature_aging1.21742517
42MP0001486_abnormal_startle_reflex1.20877060
43MP0004381_abnormal_hair_follicle1.20232082
44MP0003111_abnormal_nucleus_morphology1.18050506
45MP0009745_abnormal_behavioral_response1.17380104
46MP0004233_abnormal_muscle_weight1.15589930
47MP0006292_abnormal_olfactory_placode1.15405852
48MP0002876_abnormal_thyroid_physiology1.15171495
49MP0006276_abnormal_autonomic_nervous1.12146048
50MP0001501_abnormal_sleep_pattern1.11996550
51MP0003045_fibrosis1.11592036
52MP0008007_abnormal_cellular_replicative1.09051942
53MP0002420_abnormal_adaptive_immunity1.08648493
54MP0008995_early_reproductive_senescence1.07634778
55MP0003693_abnormal_embryo_hatching1.06682524
56MP0002452_abnormal_antigen_presenting1.06557975
57MP0001819_abnormal_immune_cell1.05722127
58MP0003121_genomic_imprinting1.05506971
59MP0005645_abnormal_hypothalamus_physiol1.04282931
60MP0002419_abnormal_innate_immunity1.02568999
61MP0002736_abnormal_nociception_after1.01689632
62MP0005647_abnormal_sex_gland1.01545788
63MP0002735_abnormal_chemical_nociception1.01241528
64MP0001765_abnormal_ion_homeostasis0.99868934
65MP0002282_abnormal_trachea_morphology0.99013097
66MP0004924_abnormal_behavior0.98024746
67MP0005386_behavior/neurological_phenoty0.98024746
68MP0002822_catalepsy0.97072862
69MP0005000_abnormal_immune_tolerance0.96994139
70MP0003890_abnormal_embryonic-extraembry0.96820531
71MP0002638_abnormal_pupillary_reflex0.95503257
72MP0006035_abnormal_mitochondrial_morpho0.93934108
73MP0000631_abnormal_neuroendocrine_gland0.93424873
74MP0002396_abnormal_hematopoietic_system0.90976060
75MP0009046_muscle_twitch0.90569486
76MP0000685_abnormal_immune_system0.88790394
77MP0002148_abnormal_hypersensitivity_rea0.87881975
78MP0002909_abnormal_adrenal_gland0.87775444
79MP0005266_abnormal_metabolism0.87324117
80MP0003077_abnormal_cell_cycle0.86706826
81MP0005025_abnormal_response_to0.86275622
82MP0000372_irregular_coat_pigmentation0.85935262
83MP0004883_abnormal_blood_vessel0.84611510
84MP0003183_abnormal_peptide_metabolism0.83938540
85MP0005171_absent_coat_pigmentation0.83202831
86MP0005387_immune_system_phenotype0.82842626
87MP0001790_abnormal_immune_system0.82842626
88MP0003172_abnormal_lysosome_physiology0.81816644
89MP0001905_abnormal_dopamine_level0.81298791
90MP0004215_abnormal_myocardial_fiber0.81096725
91MP0001970_abnormal_pain_threshold0.80921032
92MP0005253_abnormal_eye_physiology0.79806053
93MP0002163_abnormal_gland_morphology0.79441488
94MP0001485_abnormal_pinna_reflex0.79389182
95MP0002067_abnormal_sensory_capabilities0.79157586
96MP0002572_abnormal_emotion/affect_behav0.76697320
97MP0003878_abnormal_ear_physiology0.76370302
98MP0005377_hearing/vestibular/ear_phenot0.76370302
99MP0004043_abnormal_pH_regulation0.75223418
100MP0000716_abnormal_immune_system0.74825742
101MP0004484_altered_response_of0.74444477
102MP0004808_abnormal_hematopoietic_stem0.74361247
103MP0002234_abnormal_pharynx_morphology0.73611786
104MP0003950_abnormal_plasma_membrane0.70571477
105MP0001293_anophthalmia0.70492288
106MP0005551_abnormal_eye_electrophysiolog0.70319733
107MP0003011_delayed_dark_adaptation0.68719548
108MP0006072_abnormal_retinal_apoptosis0.68521699
109MP0004036_abnormal_muscle_relaxation0.63875751
110MP0000358_abnormal_cell_content/0.62314437
111MP0005391_vision/eye_phenotype0.57574536
112MP0001119_abnormal_female_reproductive0.56250434
113MP0002009_preneoplasia0.56189245
114MP0005397_hematopoietic_system_phenotyp0.55762844
115MP0001545_abnormal_hematopoietic_system0.55762844
116MP0001661_extended_life_span0.55112622
117MP0002102_abnormal_ear_morphology0.51852436
118MP0001986_abnormal_taste_sensitivity0.51149612
119MP0000569_abnormal_digit_pigmentation0.50464910
120MP0002928_abnormal_bile_duct0.49850413
121MP0000427_abnormal_hair_cycle0.47991199
122MP0001851_eye_inflammation0.47464991
123MP0003699_abnormal_female_reproductive0.47241585
124MP0000313_abnormal_cell_death0.47196931
125MP0003763_abnormal_thymus_physiology0.46731898
126MP0005409_darkened_coat_color0.45162975
127MP0001730_embryonic_growth_arrest0.44895522
128MP0001324_abnormal_eye_pigmentation0.44592938
129MP0005636_abnormal_mineral_homeostasis0.42409269
130MP0006036_abnormal_mitochondrial_physio0.41742016
131MP0002269_muscular_atrophy0.41616794
132MP0009278_abnormal_bone_marrow0.41108368
133MP0001727_abnormal_embryo_implantation0.39079381
134MP0004145_abnormal_muscle_electrophysio0.38769060
135MP0010307_abnormal_tumor_latency0.38117509
136MP0001764_abnormal_homeostasis0.37749084
137MP0004084_abnormal_cardiac_muscle0.36578190
138MP0001919_abnormal_reproductive_system0.35506729
139MP0004742_abnormal_vestibular_system0.34733655
140MP0008932_abnormal_embryonic_tissue0.34570956
141MP0004957_abnormal_blastocyst_morpholog0.34418809
142MP0005451_abnormal_body_composition0.32929070
143MP0000015_abnormal_ear_pigmentation0.32878380
144MP0000751_myopathy0.32753936
145MP0005380_embryogenesis_phenotype0.32187304
146MP0001672_abnormal_embryogenesis/_devel0.32187304
147MP0003115_abnormal_respiratory_system0.29845173
148MP0004134_abnormal_chest_morphology0.28693520
149MP0001529_abnormal_vocalization0.28576299
150MP0002084_abnormal_developmental_patter0.28491482
151MP0005666_abnormal_adipose_tissue0.28459282
152MP0002132_abnormal_respiratory_system0.28375165
153MP0002092_abnormal_eye_morphology0.27962606
154MP0004133_heterotaxia0.27921785
155MP0005075_abnormal_melanosome_morpholog0.26911058
156MP0003984_embryonic_growth_retardation0.26601875
157MP0003879_abnormal_hair_cell0.26505411
158MP0003315_abnormal_perineum_morphology0.26362409
159MP0002693_abnormal_pancreas_physiology0.26107821
160MP0002106_abnormal_muscle_physiology0.25160700
161MP0003936_abnormal_reproductive_system0.25131664
162MP0000703_abnormal_thymus_morphology0.25092940
163MP0001697_abnormal_embryo_size0.24059642
164MP0002088_abnormal_embryonic_growth/wei0.23729251
165MP0005174_abnormal_tail_pigmentation0.22522570
166MP0002405_respiratory_system_inflammati0.22480281
167MP0002080_prenatal_lethality0.21682641
168MP0000534_abnormal_ureter_morphology0.21529326
169MP0003861_abnormal_nervous_system0.20470154

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.02551419
2Abnormal respiratory motile cilium morphology (HP:0005938)8.80722048
3Abnormal respiratory epithelium morphology (HP:0012253)8.80722048
4Rhinitis (HP:0012384)7.66612921
5Abnormal ciliary motility (HP:0012262)7.43140236
6Chronic bronchitis (HP:0004469)6.90383778
7Nasal polyposis (HP:0100582)6.07293030
8Infertility (HP:0000789)5.87001018
9Abnormality of the nasal mucosa (HP:0000433)4.85865425
10Nephronophthisis (HP:0000090)4.70352749
11Bronchiectasis (HP:0002110)4.62850733
12Bronchitis (HP:0012387)4.52247312
13Abnormality of the renal medulla (HP:0100957)3.68469032
14Recurrent sinusitis (HP:0011108)3.51824707
15Tubulointerstitial nephritis (HP:0001970)3.33436005
16Recurrent otitis media (HP:0000403)3.29506911
17Abnormal spermatogenesis (HP:0008669)3.28638211
18Gonadotropin excess (HP:0000837)3.15556270
19Medial flaring of the eyebrow (HP:0010747)3.06567097
20Male infertility (HP:0003251)2.96845345
21Stomatitis (HP:0010280)2.96744363
22Recurrent bronchitis (HP:0002837)2.93489668
23Congenital stationary night blindness (HP:0007642)2.93180066
24Abnormality of midbrain morphology (HP:0002418)2.89606387
25Molar tooth sign on MRI (HP:0002419)2.89606387
26Optic neuritis (HP:0100653)2.88378709
27Retrobulbar optic neuritis (HP:0100654)2.88378709
28Elevated erythrocyte sedimentation rate (HP:0003565)2.81379993
29Hyperventilation (HP:0002883)2.69599163
30Hypochromic microcytic anemia (HP:0004840)2.52413292
31Focal motor seizures (HP:0011153)2.51713351
32Tubular atrophy (HP:0000092)2.50431263
33Orchitis (HP:0100796)2.50006544
34Abolished electroretinogram (ERG) (HP:0000550)2.49936875
35Myositis (HP:0100614)2.49861108
36Tubulointerstitial abnormality (HP:0001969)2.45699865
37Volvulus (HP:0002580)2.45271310
383-Methylglutaconic aciduria (HP:0003535)2.43831488
39Impulsivity (HP:0100710)2.42860226
40Postaxial foot polydactyly (HP:0001830)2.41415655
41Fibular hypoplasia (HP:0003038)2.41037244
42Azoospermia (HP:0000027)2.39627810
43Gaze-evoked nystagmus (HP:0000640)2.36947739
44Amyotrophic lateral sclerosis (HP:0007354)2.23544149
45Facial diplegia (HP:0001349)2.22834961
46Abnormality of the lower motor neuron (HP:0002366)2.22001309
47Oligodactyly (hands) (HP:0001180)2.21535788
48Encephalitis (HP:0002383)2.21133445
49Attenuation of retinal blood vessels (HP:0007843)2.20570850
50Renal cortical cysts (HP:0000803)2.18344463
51Stomach cancer (HP:0012126)2.17584117
52Hypothermia (HP:0002045)2.16844698
53Thyroiditis (HP:0100646)2.16555953
54Hypoplasia of the capital femoral epiphysis (HP:0003090)2.13930779
55Recurrent cutaneous fungal infections (HP:0011370)2.09300483
56Chronic mucocutaneous candidiasis (HP:0002728)2.09300483
57Abnormal rod and cone electroretinograms (HP:0008323)2.07287093
58Stage 5 chronic kidney disease (HP:0003774)2.06397353
59Abnormality of the renal cortex (HP:0011035)2.05172503
60Chronic sinusitis (HP:0011109)2.03815194
61Congenital hepatic fibrosis (HP:0002612)2.03324216
62Congenital, generalized hypertrichosis (HP:0004540)2.01816164
63Mitochondrial inheritance (HP:0001427)2.00858282
64Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.8726221
65Absent/shortened dynein arms (HP:0200106)12.4012059
66Dynein arm defect of respiratory motile cilia (HP:0012255)12.4012059
67Type II lissencephaly (HP:0007260)1.99760774
68Panhypogammaglobulinemia (HP:0003139)1.97452308
69Impaired proprioception (HP:0010831)1.96375864
70Keratoconjunctivitis (HP:0001096)1.95365345
71Progressive macrocephaly (HP:0004481)1.94709487
72Abnormal delayed hypersensitivity skin test (HP:0002963)1.94649962
73Pancreatic fibrosis (HP:0100732)1.94453882
74Widely spaced teeth (HP:0000687)1.93644548
75Congenital primary aphakia (HP:0007707)1.93333757
76Keratoconjunctivitis sicca (HP:0001097)1.93144062
77Oculomotor apraxia (HP:0000657)1.92081212
78Anencephaly (HP:0002323)1.91495589
79Hip dysplasia (HP:0001385)1.91178266
80Decreased electroretinogram (ERG) amplitude (HP:0000654)1.90991158
81Facial cleft (HP:0002006)1.90741486
82Fair hair (HP:0002286)1.90450390
83Gait imbalance (HP:0002141)1.90131376
84Hemoptysis (HP:0002105)1.89530109
85Gastrointestinal infarctions (HP:0005244)1.89495279
86Increased CSF lactate (HP:0002490)1.88987891
87Febrile seizures (HP:0002373)1.88848260
88Renal dysplasia (HP:0000110)1.88376671
89Severe combined immunodeficiency (HP:0004430)1.88065770
90Acute necrotizing encephalopathy (HP:0006965)1.87300162
91Furrowed tongue (HP:0000221)1.87200225
92Hypoplastic iliac wings (HP:0002866)1.85557764
93Supernumerary spleens (HP:0009799)1.84761196
94Methylmalonic acidemia (HP:0002912)1.83678168
95Ketoacidosis (HP:0001993)1.83583290
96Constricted visual fields (HP:0001133)1.82883522
97Absent rod-and cone-mediated responses on ERG (HP:0007688)1.82197429
98Cerebellar dysplasia (HP:0007033)1.81499173
99Papilledema (HP:0001085)1.81363848
100Exertional dyspnea (HP:0002875)1.80222155
101Postaxial hand polydactyly (HP:0001162)1.78912141
102Abnormality of permanent molar morphology (HP:0011071)1.78838262
103Abnormality of the dental root (HP:0006486)1.78838262
104Taurodontia (HP:0000679)1.78838262
105Recurrent fungal infections (HP:0002841)1.78625846
106Chronic hepatic failure (HP:0100626)1.77360592
107Lissencephaly (HP:0001339)1.77116539
108Dialeptic seizures (HP:0011146)1.77082384
109Abnormal drinking behavior (HP:0030082)1.76977135
110Polydipsia (HP:0001959)1.76977135
111Abnormality of macular pigmentation (HP:0008002)1.76934474
112Nephrogenic diabetes insipidus (HP:0009806)1.76320023
113Abnormality of alanine metabolism (HP:0010916)1.75646158
114Hyperalaninemia (HP:0003348)1.75646158
115Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.75646158
116Pendular nystagmus (HP:0012043)1.75335116
117Male pseudohermaphroditism (HP:0000037)1.75121029
118Sclerocornea (HP:0000647)1.74967517
119Hepatocellular necrosis (HP:0001404)1.73506419
120Microcytic anemia (HP:0001935)1.72791354
121Aplasia/Hypoplasia of the tibia (HP:0005772)1.72064125
122Neoplasm of the tracheobronchial system (HP:0100552)1.70401059
123Broad-based gait (HP:0002136)1.70348304
124Microglossia (HP:0000171)1.70059602
125Short ribs (HP:0000773)1.69515492
126Median cleft lip (HP:0000161)1.68258149
127Aplasia/Hypoplasia of the tongue (HP:0010295)1.68127065
128T lymphocytopenia (HP:0005403)1.67000008
129Absent speech (HP:0001344)1.66800704
130True hermaphroditism (HP:0010459)1.66651598
131Tubulointerstitial fibrosis (HP:0005576)1.66585959
132Hepatic necrosis (HP:0002605)1.66576245
133Abnormality of molar (HP:0011077)1.66036316
134Abnormality of molar morphology (HP:0011070)1.66036316
135Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.65748329
136Absent epiphyses (HP:0010577)1.65748329
137Abnormality of T cell number (HP:0011839)1.65746891
138Acute hepatic failure (HP:0006554)1.65000659
139Episodic fever (HP:0001954)1.64182741
140Retinitis pigmentosa (HP:0000510)1.63565122
141Abnormality of eosinophils (HP:0001879)1.63254482
142Alveolar cell carcinoma (HP:0006519)1.63179809
14311 pairs of ribs (HP:0000878)1.61881048
144Abnormality of the dental pulp (HP:0006479)1.60873816
145Abnormality of the anterior horn cell (HP:0006802)1.59961716
146Degeneration of anterior horn cells (HP:0002398)1.59961716
147Bell-shaped thorax (HP:0001591)1.59634452
148Abnormality of renal excretion (HP:0011036)1.57763707
149Aplasia/Hypoplasia of the fibula (HP:0006492)1.56245462
150Cystic liver disease (HP:0006706)1.56028361
151Spastic tetraparesis (HP:0001285)1.54519370
152Dyschromatopsia (HP:0007641)1.53977550
153Breast carcinoma (HP:0003002)1.44735583
154Poor coordination (HP:0002370)1.44211963
155Short thorax (HP:0010306)1.44002894
156Aplasia/Hypoplasia of the lens (HP:0008063)1.41883070
157Vaginal atresia (HP:0000148)1.40652235
158Sloping forehead (HP:0000340)1.40208667
159Absent frontal sinuses (HP:0002688)1.37878223
160Pancreatic cysts (HP:0001737)1.36787473
161Genital tract atresia (HP:0001827)1.36606676
162Type 2 muscle fiber atrophy (HP:0003554)1.35089514
163Nephropathy (HP:0000112)1.33896502
164Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.32825657
165Bundle branch block (HP:0011710)1.32747471
166Heterotopia (HP:0002282)1.32719290
167Selective tooth agenesis (HP:0001592)1.32469824
168Decreased central vision (HP:0007663)1.32011087
169Ectopic kidney (HP:0000086)1.31813627
170Bile duct proliferation (HP:0001408)1.30238895
171Abnormal biliary tract physiology (HP:0012439)1.30238895
172J-shaped sella turcica (HP:0002680)1.27002447
173Abnormality of dentin (HP:0010299)1.25139301
174Abnormality of ocular smooth pursuit (HP:0000617)1.23690794
175Asymmetric septal hypertrophy (HP:0001670)1.19791991
176Upper motor neuron abnormality (HP:0002127)1.18579977
177Large eyes (HP:0001090)1.17303504
178Abnormal urine output (HP:0012590)1.16263987

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.83615052
2PDK48.83615052
3PDK25.77542940
4TESK14.24073302
5PRKD33.63433570
6ICK2.76866412
7TAOK32.69976081
8PNCK2.67245536
9WNK42.44192488
10STK392.35353803
11ACVR1B2.25295532
12NEK22.19806466
13ADRBK22.06515312
14CDK192.01394407
15INSRR1.98717637
16CASK1.88656599
17PTK2B1.85647689
18MAP4K21.81117001
19TNIK1.68940810
20LATS11.56339443
21OXSR11.53962721
22BLK1.51413504
23WNK31.48525029
24NLK1.47973257
25CSF1R1.41888089
26FES1.39582258
27KIT1.38131493
28TNK21.37271855
29PLK41.34959037
30RIPK41.31941345
31MAPK131.30638357
32TEC1.22778718
33DAPK21.18214423
34PIK3CG1.15996078
35CDC71.14323719
36DYRK31.11978992
37MAP3K41.09274221
38WEE11.05163967
39WNK11.05016847
40CCNB11.04589928
41STK381.02847068
42LYN0.98110647
43PAK30.97856345
44ADRBK10.97700334
45PLK20.94832842
46SYK0.93731593
47BMPR20.93327920
48PASK0.92755524
49STK30.91248770
50MAPK150.90626903
51MST40.90472638
52BTK0.90019193
53IRAK40.85131697
54STK110.84472971
55PDK10.83827276
56TTK0.82815090
57MAP3K120.82711806
58IKBKE0.82383118
59DYRK1B0.81248697
60TRIM280.81090932
61GRK60.77722618
62CSK0.75928829
63KDR0.73518519
64PRKCE0.72548107
65ATR0.70520503
66MAP2K40.68917444
67IRAK10.66108463
68IKBKB0.66036996
69TYK20.65646653
70CHEK20.64741519
71CHEK10.64496309
72ITK0.64124439
73TRPM70.63232189
74BUB10.61783454
75FGR0.61434851
76MAP2K20.60953870
77BCKDK0.60950451
78PINK10.60885276
79BRSK20.59377534
80HCK0.58500241
81EIF2AK10.58279793
82MAP3K20.54808098
83LCK0.53705624
84NTRK30.52877293
85STK40.52794985
86MUSK0.52660336
87LMTK20.52637848
88TESK20.50213589
89PHKG10.49761399
90PHKG20.49761399
91AKT30.49422614
92GRK70.48595092
93JAK20.48432736
94PRKG10.48149571
95ATM0.47547323
96MAP4K10.47398454
97PRKAA20.46629848
98SGK20.46330186
99CDK30.45900814
100VRK10.45556781
101TYRO30.45006605
102MAP2K60.44988456
103CSNK1G10.44878348
104MATK0.44061745
105CSNK1G20.43434802
106ERBB30.42007637
107PLK10.41730990
108CAMK10.40899694
109CAMK1G0.39909059
110SGK10.39516249
111ABL10.39336554
112FLT30.37655577
113ZAP700.37171775
114NTRK20.36411189
115DYRK20.35619044
116STK38L0.35497600
117YES10.34139432
118BRAF0.33147068
119MARK30.33096769
120IRAK20.32285079
121TXK0.29204858
122NEK60.28884477
123PDPK10.28830994
124BMPR1B0.25616968
125BRSK10.25073956
126MAP2K70.24728260
127MARK20.23124530
128PAK10.22023518
129RPS6KA40.21599570
130NEK10.20970145
131CDK120.20868844
132RPS6KB10.20827851
133OBSCN0.20803604
134MTOR0.20258319
135PRKAA10.19268824
136CSNK2A20.19232874
137STK160.19225743
138SRPK10.18875703
139AURKB0.18370932
140ZAK0.18234011
141CSNK2A10.17605722
142MAPKAPK50.17392856
143EIF2AK30.16841446
144CDK40.16509826
145PRKCG0.16331722
146CDK20.15912727
147CDK10.14550299
148EEF2K0.11397942
149PAK20.10097546
150GSK3B0.09754536
151PKN10.09716239
152RPS6KA50.09573573
153CSNK1D0.08594938
154FRK0.08551921
155PRKDC0.08232310
156NUAK10.08039785
157TLK10.07476255
158CLK10.06700462
159PRKACB0.05963318
160EIF2AK20.05613082
161PIM10.05594820
162AURKA0.05570222
163PRKCZ0.04748941
164STK240.04630931
165PRKCQ0.04518171
166CDK70.03897705
167RPS6KA10.03507200
168CDC42BPA0.03374087
169MYLK0.03198927
170PRKCB0.03058254
171GRK10.02816585

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.65077800
2Basal transcription factors_Homo sapiens_hsa030223.65457611
3Fanconi anemia pathway_Homo sapiens_hsa034603.19886872
4Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.15940962
5Pyruvate metabolism_Homo sapiens_hsa006203.13699789
6Propanoate metabolism_Homo sapiens_hsa006402.72421784
7Fatty acid biosynthesis_Homo sapiens_hsa000612.61517856
8Asthma_Homo sapiens_hsa053102.60605120
9Glucagon signaling pathway_Homo sapiens_hsa049222.36686871
10Type I diabetes mellitus_Homo sapiens_hsa049402.34992080
11RNA transport_Homo sapiens_hsa030132.28785764
12Huntingtons disease_Homo sapiens_hsa050162.21686977
13Graft-versus-host disease_Homo sapiens_hsa053322.17839511
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.17713900
15mRNA surveillance pathway_Homo sapiens_hsa030152.13157044
16Oocyte meiosis_Homo sapiens_hsa041142.11712036
17Allograft rejection_Homo sapiens_hsa053302.10596428
18Dorso-ventral axis formation_Homo sapiens_hsa043202.09579220
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.08335410
20Protein export_Homo sapiens_hsa030602.06622519
21Pentose phosphate pathway_Homo sapiens_hsa000302.05910358
22Intestinal immune network for IgA production_Homo sapiens_hsa046722.05485688
23Linoleic acid metabolism_Homo sapiens_hsa005912.02560307
24Autoimmune thyroid disease_Homo sapiens_hsa053202.02098409
25Selenocompound metabolism_Homo sapiens_hsa004501.99645670
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.92628891
27Butanoate metabolism_Homo sapiens_hsa006501.82589664
28Regulation of autophagy_Homo sapiens_hsa041401.82579051
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.81375112
30Nicotine addiction_Homo sapiens_hsa050331.76881979
31Nitrogen metabolism_Homo sapiens_hsa009101.76808506
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.76751445
33Leishmaniasis_Homo sapiens_hsa051401.73306496
34Purine metabolism_Homo sapiens_hsa002301.70765396
35Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.69889346
36Cardiac muscle contraction_Homo sapiens_hsa042601.64717123
37Homologous recombination_Homo sapiens_hsa034401.62238665
38Staphylococcus aureus infection_Homo sapiens_hsa051501.62008775
39Glycerolipid metabolism_Homo sapiens_hsa005611.57568181
40Spliceosome_Homo sapiens_hsa030401.55399980
41Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.54158232
42Carbohydrate digestion and absorption_Homo sapiens_hsa049731.50360229
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.48044754
44Antigen processing and presentation_Homo sapiens_hsa046121.46924116
45Proteasome_Homo sapiens_hsa030501.43446127
46Glycosaminoglycan degradation_Homo sapiens_hsa005311.41331943
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.40874611
48NOD-like receptor signaling pathway_Homo sapiens_hsa046211.39070727
49Glycerophospholipid metabolism_Homo sapiens_hsa005641.33602020
50SNARE interactions in vesicular transport_Homo sapiens_hsa041301.33527207
51Amphetamine addiction_Homo sapiens_hsa050311.33504728
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.30466518
53RNA degradation_Homo sapiens_hsa030181.30079048
54Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.27683569
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.23349256
56Tryptophan metabolism_Homo sapiens_hsa003801.22476244
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.20107001
58Hematopoietic cell lineage_Homo sapiens_hsa046401.18833764
59Non-homologous end-joining_Homo sapiens_hsa034501.17508530
60Tuberculosis_Homo sapiens_hsa051521.17468874
61Pyrimidine metabolism_Homo sapiens_hsa002401.17131756
62Cysteine and methionine metabolism_Homo sapiens_hsa002701.16943069
63Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.13561590
64Rheumatoid arthritis_Homo sapiens_hsa053231.12214643
65Olfactory transduction_Homo sapiens_hsa047401.08304120
66Morphine addiction_Homo sapiens_hsa050321.07938997
67Fructose and mannose metabolism_Homo sapiens_hsa000511.03638547
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.02811741
69Ether lipid metabolism_Homo sapiens_hsa005651.02551737
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.02097243
71Renin secretion_Homo sapiens_hsa049241.00881861
72Cell cycle_Homo sapiens_hsa041100.98319278
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.96447514
74Nucleotide excision repair_Homo sapiens_hsa034200.96130023
75Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.93891724
76Carbon metabolism_Homo sapiens_hsa012000.89960877
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.88526401
78Phototransduction_Homo sapiens_hsa047440.87512335
79Peroxisome_Homo sapiens_hsa041460.85780607
80Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.84004579
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82680679
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.81920936
83DNA replication_Homo sapiens_hsa030300.81277452
84RNA polymerase_Homo sapiens_hsa030200.81072669
85GABAergic synapse_Homo sapiens_hsa047270.79165392
86Hedgehog signaling pathway_Homo sapiens_hsa043400.74800308
87beta-Alanine metabolism_Homo sapiens_hsa004100.73040440
88Caffeine metabolism_Homo sapiens_hsa002320.72230029
89African trypanosomiasis_Homo sapiens_hsa051430.71613054
90Mineral absorption_Homo sapiens_hsa049780.71223399
91Epstein-Barr virus infection_Homo sapiens_hsa051690.69438691
92Viral myocarditis_Homo sapiens_hsa054160.69229096
93Glutathione metabolism_Homo sapiens_hsa004800.68855973
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.68610481
95Serotonergic synapse_Homo sapiens_hsa047260.67370774
96Base excision repair_Homo sapiens_hsa034100.66901797
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66692978
98Mismatch repair_Homo sapiens_hsa034300.66581545
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65982396
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.64649137
101Arachidonic acid metabolism_Homo sapiens_hsa005900.62545288
102Salivary secretion_Homo sapiens_hsa049700.62212762
103Circadian entrainment_Homo sapiens_hsa047130.61766409
104Osteoclast differentiation_Homo sapiens_hsa043800.60775511
105PPAR signaling pathway_Homo sapiens_hsa033200.60511284
106B cell receptor signaling pathway_Homo sapiens_hsa046620.60356590
107cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58333538
108Legionellosis_Homo sapiens_hsa051340.58075681
109Calcium signaling pathway_Homo sapiens_hsa040200.57683479
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57674481
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57013189
112Glutamatergic synapse_Homo sapiens_hsa047240.55495696
113Sphingolipid metabolism_Homo sapiens_hsa006000.55279247
114Systemic lupus erythematosus_Homo sapiens_hsa053220.54366225
115Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54243627
116N-Glycan biosynthesis_Homo sapiens_hsa005100.51597773
117Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51593992
118Platelet activation_Homo sapiens_hsa046110.50910140
119Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50716011
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50653202
121Chemical carcinogenesis_Homo sapiens_hsa052040.46934726
122Influenza A_Homo sapiens_hsa051640.45711626
123Inositol phosphate metabolism_Homo sapiens_hsa005620.45634849
124Fatty acid elongation_Homo sapiens_hsa000620.45504054
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44833081
126Chemokine signaling pathway_Homo sapiens_hsa040620.44657884
127Malaria_Homo sapiens_hsa051440.42743986
128FoxO signaling pathway_Homo sapiens_hsa040680.41905281
129Ovarian steroidogenesis_Homo sapiens_hsa049130.41046422
130Metabolic pathways_Homo sapiens_hsa011000.40771079
131Measles_Homo sapiens_hsa051620.40582628
132Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40319650
133Collecting duct acid secretion_Homo sapiens_hsa049660.38837615
134Fatty acid metabolism_Homo sapiens_hsa012120.38808258
135Biosynthesis of amino acids_Homo sapiens_hsa012300.38604182
136Primary immunodeficiency_Homo sapiens_hsa053400.38248633
137Herpes simplex infection_Homo sapiens_hsa051680.38119299
138Insulin secretion_Homo sapiens_hsa049110.38077450
139ABC transporters_Homo sapiens_hsa020100.38016243
140Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37793733
141T cell receptor signaling pathway_Homo sapiens_hsa046600.37563128
142Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36873038
143Estrogen signaling pathway_Homo sapiens_hsa049150.36752515
144Endocytosis_Homo sapiens_hsa041440.36668134
145Long-term potentiation_Homo sapiens_hsa047200.35619744
146Toll-like receptor signaling pathway_Homo sapiens_hsa046200.34744207
147Phagosome_Homo sapiens_hsa041450.34628274
148Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33923727
149Adipocytokine signaling pathway_Homo sapiens_hsa049200.33467999
150Basal cell carcinoma_Homo sapiens_hsa052170.32704388
151p53 signaling pathway_Homo sapiens_hsa041150.32093259
152Circadian rhythm_Homo sapiens_hsa047100.31845342
153Pancreatic secretion_Homo sapiens_hsa049720.30803845
154Wnt signaling pathway_Homo sapiens_hsa043100.30793356
155Viral carcinogenesis_Homo sapiens_hsa052030.30760599
156Parkinsons disease_Homo sapiens_hsa050120.27972924
157Taste transduction_Homo sapiens_hsa047420.27513368
158Fatty acid degradation_Homo sapiens_hsa000710.26349173
159cAMP signaling pathway_Homo sapiens_hsa040240.25761646
160Alzheimers disease_Homo sapiens_hsa050100.25548080
161Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.25148489
162Alcoholism_Homo sapiens_hsa050340.25036393
163Oxidative phosphorylation_Homo sapiens_hsa001900.24650355
164Fat digestion and absorption_Homo sapiens_hsa049750.24235185

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