CEP72

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene is a member of the leucine-rich-repeat (LRR) superfamily of proteins. The protein is localized to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)8.67654519
2acrosome assembly (GO:0001675)8.33615847
3fusion of sperm to egg plasma membrane (GO:0007342)8.27940570
4sperm-egg recognition (GO:0035036)7.40487252
5cell-cell recognition (GO:0009988)7.30566773
6piRNA metabolic process (GO:0034587)7.14610938
7sperm motility (GO:0030317)6.96631369
8multicellular organism reproduction (GO:0032504)6.88365856
9binding of sperm to zona pellucida (GO:0007339)6.81640712
10cell wall macromolecule metabolic process (GO:0044036)6.72903844
11cell wall macromolecule catabolic process (GO:0016998)6.72903844
12male meiosis (GO:0007140)6.33176112
13synapsis (GO:0007129)6.32037824
14axonemal dynein complex assembly (GO:0070286)6.24724827
15plasma membrane fusion (GO:0045026)6.03496386
16spermatid development (GO:0007286)5.91220354
17motile cilium assembly (GO:0044458)5.76135562
18chromosome organization involved in meiosis (GO:0070192)5.65271359
19acrosome reaction (GO:0007340)5.61262322
20synaptonemal complex organization (GO:0070193)5.51154731
21synaptonemal complex assembly (GO:0007130)5.47143064
22reproduction (GO:0000003)5.45836107
23microtubule depolymerization (GO:0007019)5.24992452
24epithelial cilium movement (GO:0003351)5.24898117
25folic acid-containing compound biosynthetic process (GO:0009396)5.05648212
26cilium movement (GO:0003341)4.97551619
27DNA methylation involved in gamete generation (GO:0043046)4.89998757
28epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.81290617
29single strand break repair (GO:0000012)4.76392248
30regulation of dendritic cell antigen processing and presentation (GO:0002604)4.71346552
31DNA strand renaturation (GO:0000733)4.61550201
32single fertilization (GO:0007338)4.49035316
33meiotic nuclear division (GO:0007126)4.38055831
34regulation of histone H3-K9 methylation (GO:0051570)4.34780719
35positive regulation of cell size (GO:0045793)4.24368762
36regulation of cilium movement (GO:0003352)4.16492693
37male meiosis I (GO:0007141)4.12275088
38L-serine metabolic process (GO:0006563)4.02770789
39nuclear pore complex assembly (GO:0051292)4.01992111
40male gamete generation (GO:0048232)3.99143554
41spermatogenesis (GO:0007283)3.98721737
42CENP-A containing nucleosome assembly (GO:0034080)3.96213320
43fertilization (GO:0009566)3.94178750
44germ cell development (GO:0007281)3.92091681
45chromosome condensation (GO:0030261)3.90449365
46regulation of helicase activity (GO:0051095)3.87127942
47regulation of mitochondrial translation (GO:0070129)3.80290093
48positive regulation of cell cycle checkpoint (GO:1901978)3.79826375
49meiotic cell cycle process (GO:1903046)3.79378248
50DNA replication checkpoint (GO:0000076)3.77874468
51protein localization to chromosome, centromeric region (GO:0071459)3.76525085
52diaphragm development (GO:0060539)3.76425314
53nuclear pore organization (GO:0006999)3.75833566
54folic acid metabolic process (GO:0046655)3.75799556
55meiosis I (GO:0007127)3.73764540
56regulation of translational fidelity (GO:0006450)3.71781259
57positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)3.70784862
58mitotic metaphase plate congression (GO:0007080)3.70493947
59DNA packaging (GO:0006323)3.70292296
60pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.69870321
61sperm capacitation (GO:0048240)3.67899513
62cellular process involved in reproduction in multicellular organism (GO:0022412)3.66797424
63mitotic sister chromatid cohesion (GO:0007064)3.66309779
64gamete generation (GO:0007276)3.65946135
65homocysteine metabolic process (GO:0050667)3.63532063
66pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.63431499
67regulation of centriole replication (GO:0046599)3.63087442
68pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)3.62922029
69UMP biosynthetic process (GO:0006222)3.62922029
70pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)3.62922029
71UMP metabolic process (GO:0046049)3.62922029
72pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.61487529
73oogenesis (GO:0048477)3.59816287
74positive regulation of DNA-dependent DNA replication (GO:2000105)3.59721873
75regulation of nuclear cell cycle DNA replication (GO:0033262)3.57878980
76regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.57042171
77nucleotide salvage (GO:0043173)3.56673858
78DNA replication-dependent nucleosome assembly (GO:0006335)3.55558251
79DNA replication-dependent nucleosome organization (GO:0034723)3.55558251
80meiotic chromosome segregation (GO:0045132)3.54723148
81DNA replication-independent nucleosome organization (GO:0034724)3.52111408
82DNA replication-independent nucleosome assembly (GO:0006336)3.52111408
83nucleotide-excision repair, DNA gap filling (GO:0006297)3.51379042
84mitochondrial RNA metabolic process (GO:0000959)3.50400919
85regulation of T-helper 1 cell differentiation (GO:0045625)3.50095612
86histone exchange (GO:0043486)3.48128954
87DNA duplex unwinding (GO:0032508)3.48125466
88pyrimidine-containing compound salvage (GO:0008655)3.45462236
89pyrimidine nucleoside salvage (GO:0043097)3.45462236
90pyrimidine nucleoside monophosphate metabolic process (GO:0009129)3.43163267
91DNA geometric change (GO:0032392)3.40135564
92regulation of centrosome cycle (GO:0046605)3.39890365
93CTP biosynthetic process (GO:0006241)3.39787334
94CTP metabolic process (GO:0046036)3.39787334
95DNA conformation change (GO:0071103)3.39133597
96attachment of spindle microtubules to kinetochore (GO:0008608)3.37383228
97meiotic cell cycle (GO:0051321)3.35613500
98gene silencing by RNA (GO:0031047)3.34509750
99skeletal muscle organ development (GO:0060538)3.34469628
100cell recognition (GO:0008037)3.33250347
101monoubiquitinated protein deubiquitination (GO:0035520)3.32469887
102pteridine-containing compound biosynthetic process (GO:0042559)3.31115907
103regulation of spindle organization (GO:0090224)3.31107457
104sister chromatid cohesion (GO:0007062)3.30546764
105IMP biosynthetic process (GO:0006188)3.27919060
106chromatin assembly or disassembly (GO:0006333)3.27731254
107DNA strand elongation involved in DNA replication (GO:0006271)3.27219662
108pore complex assembly (GO:0046931)3.26704863
109pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.26420244
110mitotic nuclear envelope disassembly (GO:0007077)3.26199516
111pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.26099364
112nucleoside salvage (GO:0043174)3.25564236
113ribosome biogenesis (GO:0042254)3.25246003
114tetrahydrofolate metabolic process (GO:0046653)3.25015593
115telomere maintenance via telomere lengthening (GO:0010833)3.24739145
116double-strand break repair via nonhomologous end joining (GO:0006303)3.24544950
117non-recombinational repair (GO:0000726)3.24544950
118negative regulation of skeletal muscle tissue development (GO:0048642)3.21835017
119mitotic sister chromatid segregation (GO:0000070)3.19770986
120regulation of DNA endoreduplication (GO:0032875)3.18740018
121protein localization to kinetochore (GO:0034501)3.18069602
122translesion synthesis (GO:0019985)3.16625715
123regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.16620739
124regulation of DNA-dependent DNA replication (GO:0090329)3.15774447
125spermatid nucleus differentiation (GO:0007289)3.15381578
126negative regulation of inclusion body assembly (GO:0090084)3.14357921
127DNA strand elongation (GO:0022616)3.14216192
128folic acid-containing compound metabolic process (GO:0006760)3.11236150
129positive regulation of antigen processing and presentation (GO:0002579)3.10782523
130microtubule polymerization or depolymerization (GO:0031109)3.09841751
131regulation of spindle checkpoint (GO:0090231)3.08009476
132nucleobase biosynthetic process (GO:0046112)3.07798402
133chaperone-mediated protein complex assembly (GO:0051131)3.05332588
134metaphase plate congression (GO:0051310)3.04917120
135histone H3-K4 methylation (GO:0051568)3.04742274
136regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.03751487
137regulation of mitotic spindle checkpoint (GO:1903504)3.03751487
138DNA ligation (GO:0006266)3.02252953
139regulation of chromosome segregation (GO:0051983)2.99651902
140protein localization to chromosome (GO:0034502)2.98982757
141ventricular system development (GO:0021591)2.98934074
142nuclear envelope disassembly (GO:0051081)2.98855957
143membrane disassembly (GO:0030397)2.98855957
144heterochromatin organization (GO:0070828)2.98742608
145chromosome organization (GO:0051276)2.98338330
146regulation of centrosome duplication (GO:0010824)2.98239823
147serine family amino acid biosynthetic process (GO:0009070)2.98220220
148DNA unwinding involved in DNA replication (GO:0006268)2.97471896
149chromatin remodeling at centromere (GO:0031055)2.97044844
150DNA synthesis involved in DNA repair (GO:0000731)2.96930320
151sister chromatid segregation (GO:0000819)2.96674931
152ribosomal small subunit assembly (GO:0000028)2.95940957
153telomere maintenance via recombination (GO:0000722)2.95789563
154DNA replication initiation (GO:0006270)2.94296168
155positive regulation of Cdc42 GTPase activity (GO:0043089)2.93606597
156purine nucleobase biosynthetic process (GO:0009113)2.93093773
157tRNA methylation (GO:0030488)2.92914803
158positive regulation of chromosome segregation (GO:0051984)2.92715211
159DNA topological change (GO:0006265)2.91602545
160kinetochore organization (GO:0051383)2.91148147
161telomere maintenance via semi-conservative replication (GO:0032201)2.90161289
162centriole replication (GO:0007099)2.89208742
163ATP-dependent chromatin remodeling (GO:0043044)2.87787957
164mitotic chromosome condensation (GO:0007076)2.86736069
165mitotic recombination (GO:0006312)2.85989781
166seminiferous tubule development (GO:0072520)2.85167224
167gene silencing (GO:0016458)2.77499898

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.92542629
2E2F7_22180533_ChIP-Seq_HELA_Human8.74685260
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.95559357
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.45797211
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.68999026
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.15007811
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.35727331
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.26209361
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.10114370
10MYC_22102868_ChIP-Seq_BL_Human2.05640332
11AR_21909140_ChIP-Seq_LNCAP_Human2.03001544
12* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.01496152
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.97529084
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.95929910
15THAP11_20581084_ChIP-Seq_MESCs_Mouse1.88904172
16DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.84441595
17FLI1_27457419_Chip-Seq_LIVER_Mouse1.81649217
18MYC_18358816_ChIP-ChIP_MESCs_Mouse1.77849017
19MYC_19079543_ChIP-ChIP_MESCs_Mouse1.77378521
20MYC_19030024_ChIP-ChIP_MESCs_Mouse1.74353476
21MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.70803389
22* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.65175681
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.64581028
24ZNF263_19887448_ChIP-Seq_K562_Human1.62567439
25MYCN_18555785_ChIP-Seq_MESCs_Mouse1.58671182
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.57180397
27E2F1_21310950_ChIP-Seq_MCF-7_Human1.56530017
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.50848416
29SALL1_21062744_ChIP-ChIP_HESCs_Human1.50441830
30ESR1_15608294_ChIP-ChIP_MCF-7_Human1.50400116
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.50213942
32EST1_17652178_ChIP-ChIP_JURKAT_Human1.49892788
33KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.47958512
34RBPJ_22232070_ChIP-Seq_NCS_Mouse1.44954980
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.42853984
36JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.41063167
37CREB1_15753290_ChIP-ChIP_HEK293T_Human1.39890297
38XRN2_22483619_ChIP-Seq_HELA_Human1.38712647
39VDR_22108803_ChIP-Seq_LS180_Human1.37806151
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36931903
41* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.34672805
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.34128664
43CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.33727607
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.30979767
45VDR_23849224_ChIP-Seq_CD4+_Human1.30915558
46TTF2_22483619_ChIP-Seq_HELA_Human1.25812489
47PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.22989994
48GATA1_26923725_Chip-Seq_HPCs_Mouse1.22912413
49VDR_21846776_ChIP-Seq_THP-1_Human1.22584141
50ETS1_20019798_ChIP-Seq_JURKAT_Human1.22390483
51KAP1_22055183_ChIP-Seq_ESCs_Mouse1.21230097
52STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20670502
53SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.17731732
54POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16627324
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.16622972
56KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.15863989
57KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.14986646
58ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14609174
59TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14409268
60NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.10092707
61FOXP3_21729870_ChIP-Seq_TREG_Human1.08912029
62* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08357669
63KDM5A_27292631_Chip-Seq_BREAST_Human1.08214081
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06297372
65PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06127326
66* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.04816675
67FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.03675532
68TFEB_21752829_ChIP-Seq_HELA_Human1.00087042
69TET1_21451524_ChIP-Seq_MESCs_Mouse0.99516842
70ZNF274_21170338_ChIP-Seq_K562_Hela0.98659367
71CIITA_25753668_ChIP-Seq_RAJI_Human0.98174177
72* SMC4_20622854_ChIP-Seq_HELA_Human0.97863576
73* P68_20966046_ChIP-Seq_HELA_Human0.97613746
74KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97471249
75GABP_19822575_ChIP-Seq_HepG2_Human0.97377077
76SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96723747
77YY1_21170310_ChIP-Seq_MESCs_Mouse0.96678651
78POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.96071568
79CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.95545468
80HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94489441
81E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94211974
82TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.93068638
83SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.92723823
84GABP_17652178_ChIP-ChIP_JURKAT_Human0.92610210
85MYC_18940864_ChIP-ChIP_HL60_Human0.92601168
86KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.92464573
87SRF_21415370_ChIP-Seq_HL-1_Mouse0.92345982
88PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.91719165
89ELK4_26923725_Chip-Seq_MESODERM_Mouse0.91121412
90SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.90156631
91NFE2_27457419_Chip-Seq_LIVER_Mouse0.89841521
92TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.88742610
93RUNX1_26923725_Chip-Seq_HPCs_Mouse0.88726703
94POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.87054523
95HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.86990891
96ELF1_17652178_ChIP-ChIP_JURKAT_Human0.86217108
97TP63_19390658_ChIP-ChIP_HaCaT_Human0.85483240
98EZH2_22144423_ChIP-Seq_EOC_Human0.85178757
99ELK1_19687146_ChIP-ChIP_HELA_Human0.85018904
100PKCTHETA_26484144_Chip-Seq_BREAST_Human0.84987063
101ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.84814733
102SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.84610982
103GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.84338635
104BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.80628028
105DCP1A_22483619_ChIP-Seq_HELA_Human0.80548104
106TBX5_21415370_ChIP-Seq_HL-1_Mouse0.80455730
107RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.80432107
108TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80334594
109SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.79202309
110GATA3_21867929_ChIP-Seq_CD8_Mouse0.79185065
111ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.79057160
112SOX2_22085726_ChIP-Seq_NPCs_Mouse0.78849391
113SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.77998696
114FOXP1_21924763_ChIP-Seq_HESCs_Human0.77781979
115SOX17_20123909_ChIP-Seq_XEN_Mouse0.77693296
116LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.77195695
117NCOR1_26117541_ChIP-Seq_K562_Human0.76843402
118YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.76655173
119ERG_20887958_ChIP-Seq_HPC-7_Mouse0.76491424
120CHD1_26751641_Chip-Seq_LNCaP_Human0.75810737
121SUZ12_27294783_Chip-Seq_NPCs_Mouse0.75501719
122WDR5_24793694_ChIP-Seq_LNCAP_Human0.74804604
123NANOG_21062744_ChIP-ChIP_HESCs_Human0.74552322
124SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.74493327
125EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.73910503
126LXR_22292898_ChIP-Seq_THP-1_Human0.72671304
127STAT1_17558387_ChIP-Seq_HELA_Human0.72198170
128RARA_24833708_ChIP-Seq_LIVER_Mouse0.71471073
129YY1_22570637_ChIP-Seq_MALME-3M_Human0.71325377
130TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.70927037
131CTCF_26484167_Chip-Seq_Bcells_Mouse0.70081782
132ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.69995506
133HOXB4_20404135_ChIP-ChIP_EML_Mouse0.69711712
134SPI1_26923725_Chip-Seq_HPCs_Mouse0.68570984
135FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.67936370
136TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.67777541
137KLF4_18555785_ChIP-Seq_MESCs_Mouse0.67642321
138OCT4_18555785_Chip-Seq_ESCs_Mouse0.67633354
139SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.67517881
140* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.66132190
141SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.66130879
142CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.66103025
143TAL1_26923725_Chip-Seq_HPCs_Mouse0.65838855
144HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.65735526
145RXRA_24833708_ChIP-Seq_LIVER_Mouse0.65038416

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.66784567
2MP0008057_abnormal_DNA_replication5.83438815
3MP0008877_abnormal_DNA_methylation5.00208048
4MP0001929_abnormal_gametogenesis4.04419137
5MP0003698_abnormal_male_reproductive3.92248964
6MP0000566_synostosis3.82915535
7MP0010094_abnormal_chromosome_stability3.78890724
8MP0002160_abnormal_reproductive_system3.56760528
9MP0008058_abnormal_DNA_repair3.32545701
10MP0003111_abnormal_nucleus_morphology3.28846229
11MP0002210_abnormal_sex_determination3.26117069
12MP0001661_extended_life_span3.16570512
13MP0003693_abnormal_embryo_hatching3.11587863
14MP0003077_abnormal_cell_cycle2.76499897
15MP0001145_abnormal_male_reproductive2.75676764
16MP0005647_abnormal_sex_gland2.73216928
17MP0000685_abnormal_immune_system2.36142453
18MP0000653_abnormal_sex_gland2.29721188
19MP0004957_abnormal_blastocyst_morpholog2.26250045
20MP0003646_muscle_fatigue2.23410838
21MP0002161_abnormal_fertility/fecundity2.15329161
22MP0008007_abnormal_cellular_replicative2.13181669
23MP0002653_abnormal_ependyma_morphology2.05666566
24MP0005389_reproductive_system_phenotype1.94768078
25MP0004185_abnormal_adipocyte_glucose1.91597603
26MP0005645_abnormal_hypothalamus_physiol1.88278584
27MP0008932_abnormal_embryonic_tissue1.80379786
28MP0003718_maternal_effect1.75314880
29MP0003890_abnormal_embryonic-extraembry1.70501995
30MP0004858_abnormal_nervous_system1.70182565
31MP0006054_spinal_hemorrhage1.65578305
32MP0001730_embryonic_growth_arrest1.58901644
33MP0003786_premature_aging1.49977213
34MP0003705_abnormal_hypodermis_morpholog1.47893030
35MP0006292_abnormal_olfactory_placode1.46009358
36MP0002009_preneoplasia1.44641828
37MP0010307_abnormal_tumor_latency1.42030226
38MP0009672_abnormal_birth_weight1.39211329
39MP0010030_abnormal_orbit_morphology1.31457167
40MP0004043_abnormal_pH_regulation1.26450751
41MP0000467_abnormal_esophagus_morphology1.25886761
42MP0009333_abnormal_splenocyte_physiolog1.16693432
43MP0000350_abnormal_cell_proliferation1.16158213
44MP0006035_abnormal_mitochondrial_morpho1.14991645
45MP0001672_abnormal_embryogenesis/_devel1.12208066
46MP0005380_embryogenesis_phenotype1.12208066
47MP0001293_anophthalmia1.09584064
48MP0005499_abnormal_olfactory_system1.07820715
49MP0005394_taste/olfaction_phenotype1.07820715
50MP0000313_abnormal_cell_death1.03493409
51MP0001697_abnormal_embryo_size1.03236079
52MP0002085_abnormal_embryonic_tissue1.01627152
53MP0002233_abnormal_nose_morphology1.00222032
54MP0002396_abnormal_hematopoietic_system0.99921269
55MP0001119_abnormal_female_reproductive0.99904337
56MP0009697_abnormal_copulation0.99356730
57MP0010352_gastrointestinal_tract_polyps0.99342782
58MP0001346_abnormal_lacrimal_gland0.97394895
59MP0000579_abnormal_nail_morphology0.95560235
60MP0008995_early_reproductive_senescence0.95459597
61MP0001286_abnormal_eye_development0.93611588
62MP0004808_abnormal_hematopoietic_stem0.91627515
63MP0008789_abnormal_olfactory_epithelium0.91466509
64MP0002084_abnormal_developmental_patter0.91092493
65MP0003984_embryonic_growth_retardation0.90760804
66MP0005646_abnormal_pituitary_gland0.90758675
67MP0002102_abnormal_ear_morphology0.90440712
68MP0002249_abnormal_larynx_morphology0.90439134
69MP0002080_prenatal_lethality0.90290678
70MP0000733_abnormal_muscle_development0.90208631
71MP0002282_abnormal_trachea_morphology0.89371166
72MP0004133_heterotaxia0.89272371
73MP0000569_abnormal_digit_pigmentation0.88496221
74MP0002088_abnormal_embryonic_growth/wei0.87827958
75MP0003315_abnormal_perineum_morphology0.87696499
76MP0002876_abnormal_thyroid_physiology0.86180751
77MP0005623_abnormal_meninges_morphology0.85210198
78MP0003937_abnormal_limbs/digits/tail_de0.84311786
79MP0004233_abnormal_muscle_weight0.82635551
80MP0003942_abnormal_urinary_system0.81591508
81MP0001873_stomach_inflammation0.81356714
82MP0000631_abnormal_neuroendocrine_gland0.81126050
83MP0000013_abnormal_adipose_tissue0.80920305
84MP0009703_decreased_birth_body0.80842177
85MP0002019_abnormal_tumor_incidence0.80819547
86MP0002111_abnormal_tail_morphology0.78132417
87MP0001348_abnormal_lacrimal_gland0.78087651
88MP0004197_abnormal_fetal_growth/weight/0.77899246
89MP0000432_abnormal_head_morphology0.76624618
90MP0003136_yellow_coat_color0.74262388
91MP0001764_abnormal_homeostasis0.73442608
92MP0000383_abnormal_hair_follicle0.72793066
93MP0002405_respiratory_system_inflammati0.71777951
94MP0010368_abnormal_lymphatic_system0.71525341
95MP0005503_abnormal_tendon_morphology0.70460280
96MP0002822_catalepsy0.70272719
97MP0005670_abnormal_white_adipose0.69488325
98MP0001919_abnormal_reproductive_system0.69420251
99MP0005367_renal/urinary_system_phenotyp0.68157751
100MP0000516_abnormal_urinary_system0.68157751
101MP0000703_abnormal_thymus_morphology0.65915719
102MP0003763_abnormal_thymus_physiology0.65738151
103MP0002089_abnormal_postnatal_growth/wei0.65480789
104MP0005197_abnormal_uvea_morphology0.64815988
105MP0003123_paternal_imprinting0.64361943
106MP0002138_abnormal_hepatobiliary_system0.63484523
107MP0002398_abnormal_bone_marrow0.62953121
108MP0002092_abnormal_eye_morphology0.62907591
109MP0003943_abnormal_hepatobiliary_system0.62652348
110MP0002116_abnormal_craniofacial_bone0.62234431
111MP0000003_abnormal_adipose_tissue0.61574795
112MP0001835_abnormal_antigen_presentation0.61443510
113MP0000678_abnormal_parathyroid_gland0.61154372
114MP0005076_abnormal_cell_differentiation0.60474984
115MP0000537_abnormal_urethra_morphology0.60399873
116MP0003567_abnormal_fetal_cardiomyocyte0.56030940
117MP0003861_abnormal_nervous_system0.55584091
118MP0000049_abnormal_middle_ear0.54714586
119MP0001727_abnormal_embryo_implantation0.54407103
120MP0002928_abnormal_bile_duct0.54185612
121MP0002086_abnormal_extraembryonic_tissu0.53716153
122MP0000015_abnormal_ear_pigmentation0.51962620
123MP0002429_abnormal_blood_cell0.50493014
124MP0005075_abnormal_melanosome_morpholog0.50353624
125MP0003699_abnormal_female_reproductive0.49807571
126MP0002722_abnormal_immune_system0.49348866
127MP0002234_abnormal_pharynx_morphology0.47940421
128MP0009053_abnormal_anal_canal0.47616500
129MP0000689_abnormal_spleen_morphology0.47398669
130MP0005397_hematopoietic_system_phenotyp0.46731743
131MP0001545_abnormal_hematopoietic_system0.46731743
132MP0000470_abnormal_stomach_morphology0.46616717
133MP0004134_abnormal_chest_morphology0.45061079
134MP0000490_abnormal_crypts_of0.44930432
135MP0002697_abnormal_eye_size0.44013332
136MP0000716_abnormal_immune_system0.42152798
137MP0003119_abnormal_digestive_system0.42147921
138MP0002108_abnormal_muscle_morphology0.41305482
139MP0003121_genomic_imprinting0.39095113
140MP0005174_abnormal_tail_pigmentation0.38761982
141MP0002970_abnormal_white_adipose0.38600960
142MP0001800_abnormal_humoral_immune0.37007454
143MP0003115_abnormal_respiratory_system0.35925794
144MP0000358_abnormal_cell_content/0.35792359
145MP0005391_vision/eye_phenotype0.32746595

Predicted human phenotypes

RankGene SetZ-score
1Absent/shortened dynein arms (HP:0200106)9.19766616
2Dynein arm defect of respiratory motile cilia (HP:0012255)9.19766616
3Abnormal respiratory motile cilium physiology (HP:0012261)6.58809834
4Abnormal respiratory epithelium morphology (HP:0012253)6.56782753
5Abnormal respiratory motile cilium morphology (HP:0005938)6.56782753
6Rhinitis (HP:0012384)5.62409930
7Chronic bronchitis (HP:0004469)5.30164608
8Abnormal ciliary motility (HP:0012262)5.15673319
9Nasal polyposis (HP:0100582)4.59989363
10Infertility (HP:0000789)4.41526913
11Sparse lateral eyebrow (HP:0005338)4.35694380
12Lip pit (HP:0100267)4.16227867
13Anal stenosis (HP:0002025)3.97360881
14Abnormality of the fingertips (HP:0001211)3.94034891
15Abnormality of alanine metabolism (HP:0010916)3.85784830
16Hyperalaninemia (HP:0003348)3.85784830
17Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.85784830
18Abnormality of cochlea (HP:0000375)3.80260404
19Nephronophthisis (HP:0000090)3.68348522
20Intestinal fistula (HP:0100819)3.61152052
21Bronchitis (HP:0012387)3.57387275
22Abnormality of the nasal mucosa (HP:0000433)3.51506696
23Impulsivity (HP:0100710)3.42632129
24Abnormal number of incisors (HP:0011064)3.35718951
25Bronchiectasis (HP:0002110)3.35195790
26Microvesicular hepatic steatosis (HP:0001414)3.13931429
27Abnormality of the renal medulla (HP:0100957)3.13329367
28Chromosomal breakage induced by crosslinking agents (HP:0003221)3.03924385
29Chromsome breakage (HP:0040012)3.02543464
30Abnormal spermatogenesis (HP:0008669)3.01577365
31Depressed nasal tip (HP:0000437)3.00485802
32Morphological abnormality of the inner ear (HP:0011390)2.96229883
33Recurrent sinusitis (HP:0011108)2.95884485
34Hypoplasia of the capital femoral epiphysis (HP:0003090)2.92610883
35Degeneration of anterior horn cells (HP:0002398)2.82889986
36Abnormality of the anterior horn cell (HP:0006802)2.82889986
37Tongue fasciculations (HP:0001308)2.78126370
3811 pairs of ribs (HP:0000878)2.70375423
39Aplasia/Hypoplasia of the uvula (HP:0010293)2.70227204
40Recurrent otitis media (HP:0000403)2.65874381
41Selective tooth agenesis (HP:0001592)2.63817625
42Ureteral stenosis (HP:0000071)2.62488712
43Abnormality of the preputium (HP:0100587)2.58345081
44Abnormality of DNA repair (HP:0003254)2.56778356
45Ectopic kidney (HP:0000086)2.56691947
46Tubulointerstitial fibrosis (HP:0005576)2.55346555
47Gonadotropin excess (HP:0000837)2.54437510
48Supernumerary spleens (HP:0009799)2.50797179
49Autoimmune thrombocytopenia (HP:0001973)2.47537615
50Optic nerve coloboma (HP:0000588)2.47368198
51Self-mutilation (HP:0000742)2.45477750
52Recurrent bronchitis (HP:0002837)2.42202386
53Molar tooth sign on MRI (HP:0002419)2.41840628
54Abnormality of midbrain morphology (HP:0002418)2.41840628
55Abnormality of chromosome stability (HP:0003220)2.41054314
56Tubulointerstitial abnormality (HP:0001969)2.37742017
57Medial flaring of the eyebrow (HP:0010747)2.37647569
58Muscle fibrillation (HP:0010546)2.37395045
59Meckel diverticulum (HP:0002245)2.34854430
60Ureteral obstruction (HP:0006000)2.33963493
61Long palpebral fissure (HP:0000637)2.33586716
62Aplasia/Hypoplasia of the sacrum (HP:0008517)2.33056199
63Male infertility (HP:0003251)2.32064012
64Nephroblastoma (Wilms tumor) (HP:0002667)2.31828361
65Squamous cell carcinoma (HP:0002860)2.29357091
66Abnormality of the ileum (HP:0001549)2.29338831
67Sloping forehead (HP:0000340)2.27422642
68Abnormality of pyrimidine metabolism (HP:0004353)2.26116194
69Medulloblastoma (HP:0002885)2.25725473
70Abnormality of the renal cortex (HP:0011035)2.24903009
71Abnormality of homocysteine metabolism (HP:0010919)2.24245497
72Homocystinuria (HP:0002156)2.24245497
73Duodenal stenosis (HP:0100867)2.23744121
74Small intestinal stenosis (HP:0012848)2.23744121
75Duplicated collecting system (HP:0000081)2.23118893
76Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.22313747
77Absent epiphyses (HP:0010577)2.22313747
78Short thumb (HP:0009778)2.22172483
79Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.21948941
80Cafe-au-lait spot (HP:0000957)2.21736117
81Abnormality of the lower motor neuron (HP:0002366)2.20467217
82Reticulocytopenia (HP:0001896)2.20188382
83Duplication of thumb phalanx (HP:0009942)2.19869820
84Volvulus (HP:0002580)2.19464935
85Absent radius (HP:0003974)2.18561436
86High anterior hairline (HP:0009890)2.18282150
87Proximal placement of thumb (HP:0009623)2.18232867
88Azoospermia (HP:0000027)2.14286439
89Embryonal renal neoplasm (HP:0011794)2.10058815
90Facial cleft (HP:0002006)2.08253663
91Reduced subcutaneous adipose tissue (HP:0003758)2.07914734
92Absent forearm bone (HP:0003953)2.07265293
93Aplasia involving forearm bones (HP:0009822)2.07265293
94Deviation of the thumb (HP:0009603)2.05600809
95Amyotrophic lateral sclerosis (HP:0007354)2.03293187
96Septate vagina (HP:0001153)2.02016495
97Postaxial foot polydactyly (HP:0001830)2.01179962
98Ureteral duplication (HP:0000073)2.00900661
99Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.2782917
100Abnormality of the distal phalanges of the toes (HP:0010182)1.99600564
101Arteriovenous malformation (HP:0100026)1.99503825
102Abnormality of the phalanges of the 5th finger (HP:0004213)1.98806356
103Preauricular skin tag (HP:0000384)1.98416205
104Fibular hypoplasia (HP:0003038)1.97798194
105Progressive muscle weakness (HP:0003323)1.93366082
106Tubular atrophy (HP:0000092)1.92938920
107Short 4th metacarpal (HP:0010044)1.90216004
108Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.90216004
109Trismus (HP:0000211)1.89623857
110Short ribs (HP:0000773)1.89368917
111Short 5th finger (HP:0009237)1.88382947
112Skin tags (HP:0010609)1.82468773
113Pancreatic cysts (HP:0001737)1.82300323
114Clubbing of toes (HP:0100760)1.81635212
115Patellar aplasia (HP:0006443)1.81264438
116Asplenia (HP:0001746)1.80044845
117Tubulointerstitial nephritis (HP:0001970)1.79760323
118Periauricular skin pits (HP:0100277)1.79698322
119Preauricular pit (HP:0004467)1.79698322
120Congenital hepatic fibrosis (HP:0002612)1.79238351
121Dysmetric saccades (HP:0000641)1.78936438
122Abnormal lung lobation (HP:0002101)1.78727928
123Fatigue (HP:0012378)1.78170388
124Abnormality of the renal collecting system (HP:0004742)1.76462728
125Poikilocytosis (HP:0004447)1.75725900
126Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.74805937
127Abnormality of the duodenum (HP:0002246)1.73790348
128Glioma (HP:0009733)1.73049354
129Abnormality of the astrocytes (HP:0100707)1.72279501
130Astrocytoma (HP:0009592)1.72279501
131Oligodactyly (hands) (HP:0001180)1.70846716
132Abnormality of the fetal cardiovascular system (HP:0010948)1.70621831
133Abnormal umbilical cord blood vessels (HP:0011403)1.70621831
134Single umbilical artery (HP:0001195)1.70621831
135Aplasia/Hypoplasia of the patella (HP:0006498)1.70328441
136Birth length less than 3rd percentile (HP:0003561)1.69883215
137Microglossia (HP:0000171)1.69847250
138Ependymoma (HP:0002888)1.69719691
139Myelodysplasia (HP:0002863)1.67208796
140Aplasia/Hypoplasia of the spleen (HP:0010451)1.66988683
141Absent thumb (HP:0009777)1.66808852
142Coarctation of aorta (HP:0001680)1.65892845
143Intestinal malrotation (HP:0002566)1.65886273
144Pancreatic fibrosis (HP:0100732)1.65800377
145Abnormality of the umbilical cord (HP:0010881)1.65650526
146Congenital primary aphakia (HP:0007707)1.65502461
147Abnormality of the carotid arteries (HP:0005344)1.64873424
148Abnormality of subcutaneous fat tissue (HP:0001001)1.63633532
149Breast hypoplasia (HP:0003187)1.63309453
150Abnormal tarsal ossification (HP:0008369)1.62954482
151Sandal gap (HP:0001852)1.62434952
152Hypoparathyroidism (HP:0000829)1.62408591
153Upper motor neuron abnormality (HP:0002127)1.61665582
154Aplasia/Hypoplasia of the fibula (HP:0006492)1.61206762
155Oligodactyly (HP:0012165)1.61197890
156Decreased subcutaneous fat (HP:0001002)1.61083449
157Breast carcinoma (HP:0003002)1.60721959
158Abnormality of serum amino acid levels (HP:0003112)1.60499669
159Urethral obstruction (HP:0000796)1.60285036
160Heterotopia (HP:0002282)1.60281942
161Increased nuchal translucency (HP:0010880)1.59994692
162Non-midline cleft lip (HP:0100335)1.59962977
163Cystic liver disease (HP:0006706)1.59948180
164Abnormality of reticulocytes (HP:0004312)1.59677133
165Postnatal growth retardation (HP:0008897)1.59471057
166Cortical dysplasia (HP:0002539)1.59284093
167Gait imbalance (HP:0002141)1.59257577
168Chronic sinusitis (HP:0011109)1.58115501
169Anencephaly (HP:0002323)1.55931620
170Bone marrow hypocellularity (HP:0005528)1.55198401
171Renal dysplasia (HP:0000110)1.52844012
172Oculomotor apraxia (HP:0000657)1.52116878
173Missing ribs (HP:0000921)1.50569295

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK35.90543061
2PDK45.90543061
3DYRK33.70541123
4NEK23.69477065
5CDC73.59641310
6PDK23.57524626
7TESK13.38326085
8WEE13.09684201
9BUB13.03835166
10ZAK2.61092065
11ICK2.22794593
12MST1R2.21776410
13DYRK1B2.11810843
14MAP3K32.05952546
15TTK2.01187251
16PRKD31.96116405
17PLK41.82963665
18PNCK1.77203065
19SMG11.75469856
20NME21.64537016
21CDK121.61132112
22STK101.58268981
23PASK1.55375117
24VRK21.54913001
25PLK11.52961413
26EIF2AK11.50994937
27ATR1.47333722
28SRPK11.45317643
29MAP3K21.35312746
30STK391.34226502
31BRSK21.32895553
32BRSK11.31443162
33CCNB11.31262261
34CHEK11.21977932
35PIM21.21170655
36CAMK1G1.18199552
37MKNK11.17382500
38PTK2B1.16099439
39CHEK21.15677433
40NEK11.14606130
41CDK91.13168880
42CDK71.12618960
43MAPKAPK31.11264830
44STK31.09933713
45VRK11.07723444
46PLK31.02820430
47ILK1.01090508
48MET1.00534709
49AURKB0.98119287
50WNK40.97945364
51STK160.97664861
52IRAK30.95193266
53NME10.89075454
54MAP3K80.88636438
55STK40.88289560
56ATM0.87602497
57JAK30.83836454
58MKNK20.83808031
59AURKA0.82794934
60TESK20.82354067
61EPHA20.80926378
62MAPKAPK50.79492852
63PAK10.74804070
64TSSK60.71845632
65TLK10.71336110
66NEK90.71029286
67RPS6KL10.69673003
68RPS6KC10.69673003
69MAPK150.69579324
70CDK80.69018471
71TRIB30.68129728
72BLK0.67291516
73MARK30.66815540
74ARAF0.66077974
75CLK10.65912089
76BRD40.65778864
77SCYL20.65434732
78CDK40.64513262
79STK38L0.63144436
80MAP3K100.62693309
81MAPK110.60459347
82RPS6KA60.59508552
83EEF2K0.58885574
84ACVR1B0.58725990
85PAK40.57113116
86CAMK1D0.56687915
87CDK20.53709823
88CDK10.53692208
89BCR0.53672500
90TRPM70.52534592
91BRAF0.51911664
92LRRK20.46749779
93RAF10.45226707
94CSNK2A10.43953743
95ERBB30.42655035
96PINK10.42281578
97IRAK20.42250974
98MTOR0.41767983
99BMX0.41683524
100IRAK40.40824113
101CAMK10.40319308
102TRIM280.40209780
103AKT20.39264946
104RPS6KA40.39163788
105MAP4K10.38792277
106CSNK2A20.38610208
107SYK0.37955792
108PRKDC0.37710627
109CSNK1G30.36014333
110PBK0.35994005
111STK240.35363678
112TYRO30.34808947
113CAMK40.34497627
114BCKDK0.34343733
115CSNK1G20.33608511
116CSNK1A1L0.33387945
117DYRK1A0.32920463
118RPS6KB20.31816268
119WNK10.31709558
120PRKCQ0.30504649
121PIM10.29883101
122STK380.29615944
123RPS6KA10.29507350
124PRKCI0.29241759
125MAP2K30.27277471
126RPS6KA50.26563777
127CSNK1G10.26215212
128CDK60.26101399
129CSNK1D0.24973612
130MELK0.23526199
131PDK10.21855159
132CSF1R0.21730766
133BTK0.21214899
134YES10.19068078
135GSK3B0.18627150
136PAK20.17354562
137RPS6KB10.17170754
138MAPK140.16088588
139EIF2AK20.15834676
140NTRK20.12155125
141CSNK1E0.11655088

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.72316033
2Mismatch repair_Homo sapiens_hsa034304.29150354
3Homologous recombination_Homo sapiens_hsa034403.51532028
4Fanconi anemia pathway_Homo sapiens_hsa034603.30820146
5RNA transport_Homo sapiens_hsa030133.07447950
6Basal transcription factors_Homo sapiens_hsa030223.04759608
7Cell cycle_Homo sapiens_hsa041102.90654608
8Spliceosome_Homo sapiens_hsa030402.73623851
9Arginine biosynthesis_Homo sapiens_hsa002202.62004404
10Base excision repair_Homo sapiens_hsa034102.60552905
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.46839386
12Nucleotide excision repair_Homo sapiens_hsa034202.35972367
13Proteasome_Homo sapiens_hsa030502.33496700
14Non-homologous end-joining_Homo sapiens_hsa034502.31142779
15Vitamin B6 metabolism_Homo sapiens_hsa007502.10897297
16mRNA surveillance pathway_Homo sapiens_hsa030152.02072682
17Pyrimidine metabolism_Homo sapiens_hsa002401.97142557
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.87906044
19Linoleic acid metabolism_Homo sapiens_hsa005911.83387473
20Pyruvate metabolism_Homo sapiens_hsa006201.81917293
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.77816451
22Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.77231109
23Selenocompound metabolism_Homo sapiens_hsa004501.76862256
24One carbon pool by folate_Homo sapiens_hsa006701.74400291
25Oocyte meiosis_Homo sapiens_hsa041141.70309812
26Pentose phosphate pathway_Homo sapiens_hsa000301.70112551
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.69725548
28Antigen processing and presentation_Homo sapiens_hsa046121.66215416
29RNA polymerase_Homo sapiens_hsa030201.60582770
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.57952570
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.57749984
32p53 signaling pathway_Homo sapiens_hsa041151.55285472
33RNA degradation_Homo sapiens_hsa030181.50154371
34Systemic lupus erythematosus_Homo sapiens_hsa053221.47711648
35Purine metabolism_Homo sapiens_hsa002301.46131116
36Ribosome_Homo sapiens_hsa030101.40642251
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.36559606
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.27197354
39Folate biosynthesis_Homo sapiens_hsa007901.19869351
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.10046908
41Viral carcinogenesis_Homo sapiens_hsa052031.04760043
42Histidine metabolism_Homo sapiens_hsa003401.01359490
43Epstein-Barr virus infection_Homo sapiens_hsa051691.00643386
44Huntingtons disease_Homo sapiens_hsa050160.98738880
45Biosynthesis of amino acids_Homo sapiens_hsa012300.96788390
46Fatty acid biosynthesis_Homo sapiens_hsa000610.93918349
47Primary immunodeficiency_Homo sapiens_hsa053400.89663804
48Glucagon signaling pathway_Homo sapiens_hsa049220.89496184
49Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.84899649
50Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84743587
51Ether lipid metabolism_Homo sapiens_hsa005650.83458201
52Drug metabolism - other enzymes_Homo sapiens_hsa009830.82866593
53Glutathione metabolism_Homo sapiens_hsa004800.81105611
54Propanoate metabolism_Homo sapiens_hsa006400.74749745
55NF-kappa B signaling pathway_Homo sapiens_hsa040640.72886171
56Glycerolipid metabolism_Homo sapiens_hsa005610.72338752
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.72049383
58Glycerophospholipid metabolism_Homo sapiens_hsa005640.71477559
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71423683
60Carbon metabolism_Homo sapiens_hsa012000.69879872
61Basal cell carcinoma_Homo sapiens_hsa052170.69606154
62Thyroid cancer_Homo sapiens_hsa052160.68882082
63HTLV-I infection_Homo sapiens_hsa051660.67599859
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66331198
65Galactose metabolism_Homo sapiens_hsa000520.65704912
66Arachidonic acid metabolism_Homo sapiens_hsa005900.65093043
67AMPK signaling pathway_Homo sapiens_hsa041520.64590215
68Hedgehog signaling pathway_Homo sapiens_hsa043400.62325340
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60941030
70Herpes simplex infection_Homo sapiens_hsa051680.60057775
71Legionellosis_Homo sapiens_hsa051340.56301239
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54368610
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53613836
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50936115
75Fatty acid elongation_Homo sapiens_hsa000620.47885363
76N-Glycan biosynthesis_Homo sapiens_hsa005100.47306549
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.44857707
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44830467
79Fat digestion and absorption_Homo sapiens_hsa049750.44697436
80Alcoholism_Homo sapiens_hsa050340.44600380
81Arginine and proline metabolism_Homo sapiens_hsa003300.43301062
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42065093
83ABC transporters_Homo sapiens_hsa020100.39157367
84Colorectal cancer_Homo sapiens_hsa052100.37650326
85Adherens junction_Homo sapiens_hsa045200.37559720
86Non-small cell lung cancer_Homo sapiens_hsa052230.36305744
87Bladder cancer_Homo sapiens_hsa052190.35902819
88Parkinsons disease_Homo sapiens_hsa050120.33206911
89Chronic myeloid leukemia_Homo sapiens_hsa052200.32392737
90Phenylalanine metabolism_Homo sapiens_hsa003600.30035317
91MicroRNAs in cancer_Homo sapiens_hsa052060.29965566
92Hippo signaling pathway_Homo sapiens_hsa043900.29146653
93ErbB signaling pathway_Homo sapiens_hsa040120.28787621
94Small cell lung cancer_Homo sapiens_hsa052220.28756580
95Nicotine addiction_Homo sapiens_hsa050330.27380370
96Metabolic pathways_Homo sapiens_hsa011000.27175538
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26478737
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.26361953
99Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.26165264
100Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.25650798
101B cell receptor signaling pathway_Homo sapiens_hsa046620.24723853
102Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24301369
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23259879
104Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.21949624
105Dorso-ventral axis formation_Homo sapiens_hsa043200.20889179
106Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.20678032
107Alzheimers disease_Homo sapiens_hsa050100.20528707
108Measles_Homo sapiens_hsa051620.18608581
109Fructose and mannose metabolism_Homo sapiens_hsa000510.17784268
110Endometrial cancer_Homo sapiens_hsa052130.17243672
111Renin-angiotensin system_Homo sapiens_hsa046140.17112845
112Prostate cancer_Homo sapiens_hsa052150.16698572
113Regulation of autophagy_Homo sapiens_hsa041400.16590786
114Lysine degradation_Homo sapiens_hsa003100.16507587
115Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.16192153
116Taste transduction_Homo sapiens_hsa047420.15902052
117Oxidative phosphorylation_Homo sapiens_hsa001900.15573557
118Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.14937122
119Vitamin digestion and absorption_Homo sapiens_hsa049770.14517161
120Inositol phosphate metabolism_Homo sapiens_hsa005620.13428863
121Wnt signaling pathway_Homo sapiens_hsa043100.13048795
122Phototransduction_Homo sapiens_hsa047440.12241343
123Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.12087353
124Glioma_Homo sapiens_hsa052140.11119390
125Apoptosis_Homo sapiens_hsa042100.11025886
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.10904741
127Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.10570007
128Influenza A_Homo sapiens_hsa051640.08629101
129Endocytosis_Homo sapiens_hsa041440.07610111
130TGF-beta signaling pathway_Homo sapiens_hsa043500.07481150
131Tight junction_Homo sapiens_hsa045300.06031584
132Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.05757296
133Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.05471440
134Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.05059651
135Sulfur relay system_Homo sapiens_hsa041220.02212968
136Leukocyte transendothelial migration_Homo sapiens_hsa046700.01551731
137Pathways in cancer_Homo sapiens_hsa052000.01392986
138Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0068198

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