CEP76

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a centrosomal protein which regulates centriole amplification by limiting centriole duplication to once per cell cycle. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX metabolic process (GO:0046501)5.60553423
2protein localization to kinetochore (GO:0034501)5.44066020
3DNA unwinding involved in DNA replication (GO:0006268)5.30032787
4protoporphyrinogen IX biosynthetic process (GO:0006782)5.19791253
5mitotic metaphase plate congression (GO:0007080)5.11167438
6nuclear pore organization (GO:0006999)5.03265457
7regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)5.03027240
8DNA replication initiation (GO:0006270)5.01699701
9protein localization to chromosome, centromeric region (GO:0071459)4.97516145
10sister chromatid segregation (GO:0000819)4.96547495
11mitotic chromosome condensation (GO:0007076)4.96469668
12DNA replication checkpoint (GO:0000076)4.95724712
13nuclear pore complex assembly (GO:0051292)4.83889753
14DNA replication-dependent nucleosome assembly (GO:0006335)4.78915844
15DNA replication-dependent nucleosome organization (GO:0034723)4.78915844
16mitotic sister chromatid segregation (GO:0000070)4.77923613
17regulation of spindle organization (GO:0090224)4.63845982
18mitotic nuclear envelope disassembly (GO:0007077)4.56673799
19positive regulation of chromosome segregation (GO:0051984)4.54375078
20behavioral response to nicotine (GO:0035095)4.54317158
21DNA strand elongation involved in DNA replication (GO:0006271)4.48991629
22regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.47073397
23metaphase plate congression (GO:0051310)4.44149814
24attachment of spindle microtubules to kinetochore (GO:0008608)4.42158013
25chromatin remodeling at centromere (GO:0031055)4.39511305
26CENP-A containing nucleosome assembly (GO:0034080)4.39444034
27synapsis (GO:0007129)4.39173182
28nuclear envelope disassembly (GO:0051081)4.29580857
29membrane disassembly (GO:0030397)4.29580857
30translesion synthesis (GO:0019985)4.27866652
31DNA strand elongation (GO:0022616)4.23496642
32DNA replication-independent nucleosome assembly (GO:0006336)4.20355044
33DNA replication-independent nucleosome organization (GO:0034724)4.20355044
34kinetochore organization (GO:0051383)4.17495891
35regulation of mitotic spindle organization (GO:0060236)4.14937270
36folic acid-containing compound biosynthetic process (GO:0009396)4.12725859
37mitotic sister chromatid cohesion (GO:0007064)4.12114366
38telomere maintenance via semi-conservative replication (GO:0032201)4.09851817
39DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla4.08479582
40establishment of chromosome localization (GO:0051303)3.98414021
41protein K6-linked ubiquitination (GO:0085020)3.93771029
42positive regulation of mitotic sister chromatid separation (GO:1901970)3.92200930
43positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.92200930
44positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.92200930
45histone exchange (GO:0043486)3.91732802
46DNA damage response, signal transduction resulting in transcription (GO:0042772)3.86301864
47chromatin assembly or disassembly (GO:0006333)3.85904489
48piRNA metabolic process (GO:0034587)3.85721910
49mitotic recombination (GO:0006312)3.85616987
50porphyrin-containing compound biosynthetic process (GO:0006779)3.82687728
51microtubule depolymerization (GO:0007019)3.77614365
52telomere maintenance via recombination (GO:0000722)3.74067928
53regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.72082346
54meiotic chromosome segregation (GO:0045132)3.71945472
55* regulation of centrosome cycle (GO:0046605)3.69608965
56protein localization to chromosome (GO:0034502)3.68484365
57L-fucose catabolic process (GO:0042355)3.66159955
58fucose catabolic process (GO:0019317)3.66159955
59L-fucose metabolic process (GO:0042354)3.66159955
60* regulation of centriole replication (GO:0046599)3.62426055
61regulation of DNA endoreduplication (GO:0032875)3.62146521
62pore complex assembly (GO:0046931)3.60773407
63regulation of chromosome segregation (GO:0051983)3.60698982
64chromosome condensation (GO:0030261)3.57365318
65chromosome segregation (GO:0007059)3.52839735
66replication fork processing (GO:0031297)3.50498708
67postreplication repair (GO:0006301)3.47565886
68IMP biosynthetic process (GO:0006188)3.42878264
69regulation of sister chromatid cohesion (GO:0007063)3.41332980
70spindle checkpoint (GO:0031577)3.41167399
71kinetochore assembly (GO:0051382)3.40295548
72nuclear envelope organization (GO:0006998)3.39819345
73negative regulation of DNA-dependent DNA replication (GO:2000104)3.39749465
74regulation of mitotic metaphase/anaphase transition (GO:0030071)3.38690525
75DNA duplex unwinding (GO:0032508)3.34658802
76ATP-dependent chromatin remodeling (GO:0043044)3.34615454
77DNA topological change (GO:0006265)3.34060563
78DNA geometric change (GO:0032392)3.33562098
79tetrapyrrole biosynthetic process (GO:0033014)3.32941847
80nucleobase biosynthetic process (GO:0046112)3.31086312
81regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.30893124
82telomere maintenance via telomere lengthening (GO:0010833)3.26826704
83chromatin assembly (GO:0031497)3.26802299
84heme biosynthetic process (GO:0006783)3.26399211
85regulation of nuclear cell cycle DNA replication (GO:0033262)3.24821506
86purine nucleobase biosynthetic process (GO:0009113)3.24655830
87ribosome assembly (GO:0042255)3.23230220
88nucleosome assembly (GO:0006334)3.20988938
89DNA double-strand break processing (GO:0000729)3.20642664
90protein-cofactor linkage (GO:0018065)3.20054954
91regulation of histone H3-K9 methylation (GO:0051570)3.19816539
92histone-serine phosphorylation (GO:0035404)3.19370880
93DNA packaging (GO:0006323)3.18674726
94regulation of RNA export from nucleus (GO:0046831)3.18151786
95negative regulation of chromosome segregation (GO:0051985)3.17601636
96spindle assembly checkpoint (GO:0071173)3.17050128
97negative regulation of mitotic sister chromatid separation (GO:2000816)3.14580571
98negative regulation of mitotic sister chromatid segregation (GO:0033048)3.14580571
99negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.14580571
100negative regulation of sister chromatid segregation (GO:0033046)3.14580571
101detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.13705459
102regulation of mitotic spindle checkpoint (GO:1903504)3.12188382
103regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.12188382
104reciprocal meiotic recombination (GO:0007131)3.11964594
105reciprocal DNA recombination (GO:0035825)3.11964594
106regulation of mitotic sister chromatid separation (GO:0010965)3.11661925
107regulation of mitotic sister chromatid segregation (GO:0033047)3.11661925
108regulation of sister chromatid segregation (GO:0033045)3.11661925
109* mitotic cell cycle (GO:0000278)3.10965092
110nucleotide-excision repair, DNA gap filling (GO:0006297)3.10734282
111DNA methylation involved in gamete generation (GO:0043046)3.10003025
112DNA conformation change (GO:0071103)3.09027726
113mitotic spindle checkpoint (GO:0071174)3.08224386
114mitotic DNA integrity checkpoint (GO:0044774)3.07691499
115negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.05198934
116mitotic spindle assembly checkpoint (GO:0007094)3.04587439
117negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.04361262
118respiratory chain complex IV assembly (GO:0008535)3.00343014
119protein K11-linked deubiquitination (GO:0035871)2.96766936
120somatic hypermutation of immunoglobulin genes (GO:0016446)2.96049354
121somatic diversification of immune receptors via somatic mutation (GO:0002566)2.96049354
122centriole replication (GO:0007099)2.95986614
123response to pheromone (GO:0019236)2.95523498
124retinal cone cell development (GO:0046549)2.94933854
125male meiosis I (GO:0007141)2.93766792
126recombinational repair (GO:0000725)2.93184966
127protein polyglutamylation (GO:0018095)2.92892853
128maturation of 5.8S rRNA (GO:0000460)2.92023535
129double-strand break repair via homologous recombination (GO:0000724)2.91579664
130mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.88879714
131mitochondrial respiratory chain complex I assembly (GO:0032981)2.88879714
132NADH dehydrogenase complex assembly (GO:0010257)2.88879714
133nonmotile primary cilium assembly (GO:0035058)2.88092740
134maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.86906616
135cellular ketone body metabolic process (GO:0046950)2.86495553
136protein complex biogenesis (GO:0070271)2.83339773
137regulation of hexokinase activity (GO:1903299)2.81312867
138regulation of glucokinase activity (GO:0033131)2.81312867
139detection of light stimulus involved in sensory perception (GO:0050962)2.79159724
140detection of light stimulus involved in visual perception (GO:0050908)2.79159724
141RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.78930475
142mitochondrial respiratory chain complex assembly (GO:0033108)2.78794558
143ubiquinone biosynthetic process (GO:0006744)2.77589183
144male meiosis (GO:0007140)2.77113478
145water-soluble vitamin biosynthetic process (GO:0042364)2.76572746
146platelet dense granule organization (GO:0060155)2.75344115
147G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.72401007
148neural tube formation (GO:0001841)2.70563009
149C4-dicarboxylate transport (GO:0015740)2.70388631
150regulation of cilium movement (GO:0003352)2.68772382
151ubiquinone metabolic process (GO:0006743)2.67495670
152L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.63255330
153epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.59356480
154epithelial cilium movement (GO:0003351)2.58356211
155ketone body metabolic process (GO:1902224)2.58324953
156cytochrome complex assembly (GO:0017004)2.58122211
157resolution of meiotic recombination intermediates (GO:0000712)2.57449544
158indolalkylamine metabolic process (GO:0006586)2.56956018
159rRNA catabolic process (GO:0016075)2.55216277
160negative regulation of telomere maintenance (GO:0032205)2.54566203
161pseudouridine synthesis (GO:0001522)2.54203416
162tRNA processing (GO:0008033)2.53785106
163kynurenine metabolic process (GO:0070189)2.53367746
164auditory receptor cell stereocilium organization (GO:0060088)2.52407918
165preassembly of GPI anchor in ER membrane (GO:0016254)2.50822303
166regulation of meiosis I (GO:0060631)2.49717512
167primary amino compound metabolic process (GO:1901160)2.46697936
168exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.45597263
169nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.44246447
170tryptophan catabolic process (GO:0006569)2.43792164
171indole-containing compound catabolic process (GO:0042436)2.43792164
172indolalkylamine catabolic process (GO:0046218)2.43792164
173chromosome organization involved in meiosis (GO:0070192)2.43714805
174DNA deamination (GO:0045006)2.43709942
175cilium morphogenesis (GO:0060271)2.43491169
176cullin deneddylation (GO:0010388)2.42925154
177photoreceptor cell maintenance (GO:0045494)2.42220119
178proteasome assembly (GO:0043248)2.42135265
179mannosylation (GO:0097502)2.40626865
180nucleotide transmembrane transport (GO:1901679)2.39931354
181protein localization to cilium (GO:0061512)2.38902593
182reflex (GO:0060004)2.38762800
183cilium organization (GO:0044782)2.38732154
184establishment of protein localization to mitochondrial membrane (GO:0090151)2.38573913
185somite rostral/caudal axis specification (GO:0032525)2.36960265
186mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.36146911
187meiosis I (GO:0007127)2.35403757
188tRNA modification (GO:0006400)2.34605883
189protein deneddylation (GO:0000338)2.34550469

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.85516055
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.98324843
3* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.00812796
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.79114197
5ZNF274_21170338_ChIP-Seq_K562_Hela3.67149346
6VDR_22108803_ChIP-Seq_LS180_Human3.47627664
7AR_21909140_ChIP-Seq_LNCAP_Human3.30525877
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.26160489
9GBX2_23144817_ChIP-Seq_PC3_Human2.87030372
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.78800091
11E2F1_21310950_ChIP-Seq_MCF-7_Human2.67821605
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.65748801
13FUS_26573619_Chip-Seq_HEK293_Human2.59466492
14* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.57136404
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.52813561
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.46262072
17EWS_26573619_Chip-Seq_HEK293_Human2.45405635
18TAF15_26573619_Chip-Seq_HEK293_Human2.44864588
19IGF1R_20145208_ChIP-Seq_DFB_Human2.39254661
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.37792106
21* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.36924262
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.33362223
23FLI1_27457419_Chip-Seq_LIVER_Mouse2.27619463
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.20652239
25CREB1_15753290_ChIP-ChIP_HEK293T_Human2.14617809
26* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.10209997
27MYC_18358816_ChIP-ChIP_MESCs_Mouse2.09596164
28* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.04872891
29EGR1_19374776_ChIP-ChIP_THP-1_Human2.03150316
30E2F7_22180533_ChIP-Seq_HELA_Human11.7096093
31P300_19829295_ChIP-Seq_ESCs_Human1.97238852
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97036492
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.96759848
34* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.90041646
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.89136259
36* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87692474
37EST1_17652178_ChIP-ChIP_JURKAT_Human1.85738158
38ETS1_20019798_ChIP-Seq_JURKAT_Human1.79175967
39VDR_23849224_ChIP-Seq_CD4+_Human1.78835608
40XRN2_22483619_ChIP-Seq_HELA_Human1.77324153
41ER_23166858_ChIP-Seq_MCF-7_Human1.76001916
42MYC_22102868_ChIP-Seq_BL_Human1.73044846
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72721736
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.70014090
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68017881
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65270973
47HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.60877136
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54150827
49JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.53871482
50CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.53170995
51CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.52761697
52UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52234300
53IRF1_19129219_ChIP-ChIP_H3396_Human1.52182234
54AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.50142310
55GABP_17652178_ChIP-ChIP_JURKAT_Human1.48892222
56GABP_19822575_ChIP-Seq_HepG2_Human1.47852064
57YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47593743
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.46277707
59E2F1_18555785_ChIP-Seq_MESCs_Mouse1.45426222
60* TP53_22573176_ChIP-Seq_HFKS_Human1.45352777
61STAT3_23295773_ChIP-Seq_U87_Human1.45034326
62MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44770043
63ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44103759
64CIITA_25753668_ChIP-Seq_RAJI_Human1.44010925
65FOXP3_21729870_ChIP-Seq_TREG_Human1.43931287
66* DCP1A_22483619_ChIP-Seq_HELA_Human1.43820385
67THAP11_20581084_ChIP-Seq_MESCs_Mouse1.42686159
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.42533718
69POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.42204493
70SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.40950491
71ELK1_19687146_ChIP-ChIP_HELA_Human1.39828978
72CBP_20019798_ChIP-Seq_JUKART_Human1.39198346
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39198346
74PADI4_21655091_ChIP-ChIP_MCF-7_Human1.39019924
75SMAD4_21799915_ChIP-Seq_A2780_Human1.38619278
76KDM5A_27292631_Chip-Seq_BREAST_Human1.38604319
77NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.38130337
78TCF4_23295773_ChIP-Seq_U87_Human1.37021293
79EZH2_22144423_ChIP-Seq_EOC_Human1.36252786
80* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.35323249
81* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.34570367
82CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.34516606
83E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.33759514
84AR_25329375_ChIP-Seq_VCAP_Human1.32556518
85TTF2_22483619_ChIP-Seq_HELA_Human1.31957894
86HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.30627774
87BCAT_22108803_ChIP-Seq_LS180_Human1.27648094
88CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27586614
89* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27548895
90NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.26822201
91SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26208308
92E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.24587965
93SALL1_21062744_ChIP-ChIP_HESCs_Human1.24126703
94TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.23444196
95PIAS1_25552417_ChIP-Seq_VCAP_Human1.23303841
96EZH2_27294783_Chip-Seq_NPCs_Mouse1.23298412
97NANOG_19829295_ChIP-Seq_ESCs_Human1.23290801
98SOX2_19829295_ChIP-Seq_ESCs_Human1.23290801
99GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22978221
100TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22869941
101PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21568768
102SOX2_18555785_ChIP-Seq_MESCs_Mouse1.21281485
103FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18996592
104NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.18374298
105KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18073915
106TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18063665
107POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18063665
108SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.16785085
109TP63_19390658_ChIP-ChIP_HaCaT_Human1.16757741
110PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16738865
111TCF4_22108803_ChIP-Seq_LS180_Human1.15669352
112SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14727437
113SMAD3_21741376_ChIP-Seq_EPCs_Human1.13718714
114BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13660046
115SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12859898
116KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12668071
117NFE2_27457419_Chip-Seq_LIVER_Mouse1.12249352
118OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11840772
119SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.11835887
120FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11813393
121FOXA1_25329375_ChIP-Seq_VCAP_Human1.11813393
122CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.11314618
123NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11053224
124TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10988815
125RUNX2_22187159_ChIP-Seq_PCA_Human1.10811461
126HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10455274
127HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.09535119
128NANOG_21062744_ChIP-ChIP_HESCs_Human1.08632162
129GATA1_22025678_ChIP-Seq_K562_Human1.08601835
130FLI1_21867929_ChIP-Seq_TH2_Mouse1.06003162
131SMAD4_21741376_ChIP-Seq_EPCs_Human1.05934140
132FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05715532
133SRF_21415370_ChIP-Seq_HL-1_Mouse1.05231551
134ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.04775678
135SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.03624167
136TFEB_21752829_ChIP-Seq_HELA_Human1.02382550
137CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.02205565
138ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02131024
139HOXB7_26014856_ChIP-Seq_BT474_Human1.01622112
140DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01342135
141* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00943558
142RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.00534780
143ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.00184787
144HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.99328019
145RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98139164
146POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97560105
147NANOG_18555785_Chip-Seq_ESCs_Mouse0.97396492
148TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97350727
149ELF1_17652178_ChIP-ChIP_JURKAT_Human0.97155215
150BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.96824129
151CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96797376
152NCOR_22424771_ChIP-Seq_293T_Human0.96586981
153AR_21572438_ChIP-Seq_LNCaP_Human0.96506484
154SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95298136
155SOX2_16153702_ChIP-ChIP_HESCs_Human0.94185143
156KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.93217239
157STAT3_1855785_ChIP-Seq_MESCs_Mouse0.88771053
158VDR_21846776_ChIP-Seq_THP-1_Human0.88765222
159ZNF263_19887448_ChIP-Seq_K562_Human0.88102334
160GATA1_19941826_ChIP-Seq_K562_Human0.88031397
161ESR1_15608294_ChIP-ChIP_MCF-7_Human0.86029101
162CHD1_26751641_Chip-Seq_LNCaP_Human0.85581816
163POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.85361392
164MYC_18940864_ChIP-ChIP_HL60_Human0.83231253
165PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.79290571
166CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.77382086
167KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.74979944
168NCOR1_26117541_ChIP-Seq_K562_Human0.74367546
169GATA1_22383799_ChIP-Seq_G1ME_Mouse0.74258703
170YY1_21170310_ChIP-Seq_MESCs_Mouse0.74043729
171BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.73450434
172SCL_19346495_ChIP-Seq_HPC-7_Human0.73401387
173RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.69760235
174NANOG_16153702_ChIP-ChIP_HESCs_Human0.69473803
175UTX_26944678_Chip-Seq_JUKART_Human0.69191463
176POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.66673747

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level5.26321944
2MP0003111_abnormal_nucleus_morphology5.09662855
3MP0003693_abnormal_embryo_hatching4.97323260
4MP0010094_abnormal_chromosome_stability4.94124819
5MP0003656_abnormal_erythrocyte_physiolo3.99381890
6MP0003077_abnormal_cell_cycle3.93573696
7MP0004957_abnormal_blastocyst_morpholog3.79033820
8MP0008057_abnormal_DNA_replication3.28033656
9MP0010307_abnormal_tumor_latency3.12006745
10MP0008058_abnormal_DNA_repair2.97806457
11MP0008007_abnormal_cellular_replicative2.57947061
12MP0001730_embryonic_growth_arrest2.45123474
13MP0000350_abnormal_cell_proliferation2.39722578
14MP0005076_abnormal_cell_differentiation2.38554149
15MP0003195_calcinosis2.32251034
16MP0008877_abnormal_DNA_methylation2.28528639
17MP0008932_abnormal_embryonic_tissue2.28393854
18MP0000569_abnormal_digit_pigmentation2.15727951
19MP0005551_abnormal_eye_electrophysiolog2.06331463
20MP0001968_abnormal_touch/_nociception2.02012970
21MP0002102_abnormal_ear_morphology1.98203279
22MP0004742_abnormal_vestibular_system1.93080189
23MP0001697_abnormal_embryo_size1.90604905
24MP0002272_abnormal_nervous_system1.90407954
25MP0001672_abnormal_embryogenesis/_devel1.89860343
26MP0005380_embryogenesis_phenotype1.89860343
27MP0003705_abnormal_hypodermis_morpholog1.85952411
28MP0000372_irregular_coat_pigmentation1.85252004
29MP0001984_abnormal_olfaction1.85057909
30MP0002638_abnormal_pupillary_reflex1.82320840
31MP0002736_abnormal_nociception_after1.82174822
32MP0003136_yellow_coat_color1.78054034
33MP0003984_embryonic_growth_retardation1.74621163
34MP0003123_paternal_imprinting1.72641695
35MP0010352_gastrointestinal_tract_polyps1.71958446
36MP0005253_abnormal_eye_physiology1.70142047
37MP0002088_abnormal_embryonic_growth/wei1.70027363
38MP0002080_prenatal_lethality1.67305532
39MP0003880_abnormal_central_pattern1.67034790
40MP0008872_abnormal_physiological_respon1.66682245
41MP0002085_abnormal_embryonic_tissue1.66284509
42MP0008875_abnormal_xenobiotic_pharmacok1.66069590
43MP0000427_abnormal_hair_cycle1.62166345
44MP0004197_abnormal_fetal_growth/weight/1.61756650
45MP0003787_abnormal_imprinting1.58003153
46MP0009697_abnormal_copulation1.57769063
47MP0005410_abnormal_fertilization1.54378049
48MP0009745_abnormal_behavioral_response1.54169418
49MP0002938_white_spotting1.53584024
50MP0010386_abnormal_urinary_bladder1.52989189
51MP0002086_abnormal_extraembryonic_tissu1.52914789
52MP0002653_abnormal_ependyma_morphology1.47146082
53MP0004043_abnormal_pH_regulation1.44644968
54MP0004133_heterotaxia1.44315432
55MP0000313_abnormal_cell_death1.41710835
56MP0002396_abnormal_hematopoietic_system1.40987474
57MP0002084_abnormal_developmental_patter1.40136646
58MP0004808_abnormal_hematopoietic_stem1.39684886
59MP0003646_muscle_fatigue1.37112712
60MP0003011_delayed_dark_adaptation1.36976935
61MP0004142_abnormal_muscle_tone1.33221001
62MP0001485_abnormal_pinna_reflex1.33117894
63MP0001529_abnormal_vocalization1.30770423
64MP0001486_abnormal_startle_reflex1.30243586
65MP0005174_abnormal_tail_pigmentation1.29690233
66MP0002019_abnormal_tumor_incidence1.29181423
67MP0002210_abnormal_sex_determination1.28956902
68MP0006276_abnormal_autonomic_nervous1.28092098
69MP0002876_abnormal_thyroid_physiology1.24368153
70MP0002837_dystrophic_cardiac_calcinosis1.23566971
71MP0001929_abnormal_gametogenesis1.23340185
72MP0001545_abnormal_hematopoietic_system1.21948613
73MP0005397_hematopoietic_system_phenotyp1.21948613
74MP0005645_abnormal_hypothalamus_physiol1.20683700
75MP0000490_abnormal_crypts_of1.20667013
76MP0000631_abnormal_neuroendocrine_gland1.20350387
77MP0003786_premature_aging1.18595250
78MP0002067_abnormal_sensory_capabilities1.18127018
79MP0009672_abnormal_birth_weight1.16217983
80MP0005083_abnormal_biliary_tract1.15233524
81MP0005386_behavior/neurological_phenoty1.13260759
82MP0004924_abnormal_behavior1.13260759
83MP0006292_abnormal_olfactory_placode1.13138109
84MP0001501_abnormal_sleep_pattern1.12938137
85MP0001145_abnormal_male_reproductive1.12645379
86MP0005646_abnormal_pituitary_gland1.12145065
87MP0003890_abnormal_embryonic-extraembry1.07420045
88MP0000653_abnormal_sex_gland1.07409837
89MP0001293_anophthalmia1.07392164
90MP0002557_abnormal_social/conspecific_i1.06418580
91MP0003121_genomic_imprinting1.05574271
92MP0003567_abnormal_fetal_cardiomyocyte1.04274247
93MP0002163_abnormal_gland_morphology1.03594315
94MP0002751_abnormal_autonomic_nervous1.03530616
95MP0000703_abnormal_thymus_morphology1.03226767
96MP0002064_seizures1.02944661
97MP0002234_abnormal_pharynx_morphology1.02523294
98MP0002095_abnormal_skin_pigmentation1.02093076
99MP0002572_abnormal_emotion/affect_behav1.01384917
100MP0005379_endocrine/exocrine_gland_phen1.00122487
101MP0000383_abnormal_hair_follicle0.99030817
102MP0000647_abnormal_sebaceous_gland0.97641743
103MP0005621_abnormal_cell_physiology0.95346723
104MP0010030_abnormal_orbit_morphology0.93652543
105MP0005084_abnormal_gallbladder_morpholo0.93564441
106MP0008995_early_reproductive_senescence0.91972196
107MP0002735_abnormal_chemical_nociception0.91955619
108MP0002160_abnormal_reproductive_system0.91024848
109MP0002877_abnormal_melanocyte_morpholog0.90974902
110MP0003315_abnormal_perineum_morphology0.89722326
111MP0009703_decreased_birth_body0.89630360
112MP0003635_abnormal_synaptic_transmissio0.89292479
113MP0000015_abnormal_ear_pigmentation0.88959883
114MP0005384_cellular_phenotype0.88889269
115MP0003119_abnormal_digestive_system0.88337828
116MP0002184_abnormal_innervation0.87419014
117MP0004885_abnormal_endolymph0.86397445
118MP0002398_abnormal_bone_marrow0.85093183
119MP0003698_abnormal_male_reproductive0.84360059
120MP0005075_abnormal_melanosome_morpholog0.84149428
121MP0001849_ear_inflammation0.83960056
122MP0003718_maternal_effect0.83627684
123MP0009053_abnormal_anal_canal0.83219939
124MP0000733_abnormal_muscle_development0.82128632
125MP0003937_abnormal_limbs/digits/tail_de0.81837170
126MP0001986_abnormal_taste_sensitivity0.81788547
127MP0000428_abnormal_craniofacial_morphol0.81686483
128MP0002161_abnormal_fertility/fecundity0.81275652
129MP0002928_abnormal_bile_duct0.80541839
130MP0002722_abnormal_immune_system0.79748380
131MP0003861_abnormal_nervous_system0.79650578
132MP0001440_abnormal_grooming_behavior0.78932620
133MP0008770_decreased_survivor_rate0.77819532
134MP0008260_abnormal_autophagy0.76011341
135MP0005391_vision/eye_phenotype0.75779955
136MP0001119_abnormal_female_reproductive0.75730116
137MP0005195_abnormal_posterior_eye0.75256384
138MP0002063_abnormal_learning/memory/cond0.75226025
139MP0002111_abnormal_tail_morphology0.75026692
140MP0003221_abnormal_cardiomyocyte_apopto0.74304403
141MP0000358_abnormal_cell_content/0.73832425
142MP0000689_abnormal_spleen_morphology0.73771627
143MP0009278_abnormal_bone_marrow0.71859503
144MP0000432_abnormal_head_morphology0.71568952
145MP0003699_abnormal_female_reproductive0.70741814
146MP0005187_abnormal_penis_morphology0.70374349
147MP0001915_intracranial_hemorrhage0.70068089
148MP0005389_reproductive_system_phenotype0.68419545
149MP0001286_abnormal_eye_development0.67687216
150MP0003943_abnormal_hepatobiliary_system0.64046846
151MP0006072_abnormal_retinal_apoptosis0.63624432
152MP0008789_abnormal_olfactory_epithelium0.62916307
153MP0003935_abnormal_craniofacial_develop0.62474973
154MP0003806_abnormal_nucleotide_metabolis0.62466442
155MP0002092_abnormal_eye_morphology0.62152418
156MP0009046_muscle_twitch0.62138216
157MP0006035_abnormal_mitochondrial_morpho0.60823478
158MP0005499_abnormal_olfactory_system0.60380918
159MP0005394_taste/olfaction_phenotype0.60380918
160MP0000537_abnormal_urethra_morphology0.59969415
161MP0003632_abnormal_nervous_system0.59852254
162MP0009333_abnormal_splenocyte_physiolog0.57590350
163MP0001919_abnormal_reproductive_system0.57278984
164MP0000266_abnormal_heart_morphology0.55906791
165MP0002925_abnormal_cardiovascular_devel0.55476144
166MP0004215_abnormal_myocardial_fiber0.53448970

Predicted human phenotypes

RankGene SetZ-score
1Poikilocytosis (HP:0004447)6.67255599
2Abnormality of the heme biosynthetic pathway (HP:0010472)5.45744029
3Birth length less than 3rd percentile (HP:0003561)4.97346348
4Reticulocytosis (HP:0001923)4.31906408
5Acanthocytosis (HP:0001927)4.02847390
6Impulsivity (HP:0100710)3.76412406
7Hypochromic microcytic anemia (HP:0004840)3.74212313
8Pancreatic cysts (HP:0001737)3.72878276
9Abnormality of midbrain morphology (HP:0002418)3.54992945
10Molar tooth sign on MRI (HP:0002419)3.54992945
11Pancreatic fibrosis (HP:0100732)3.44289255
12Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.42268832
13Abnormality of alanine metabolism (HP:0010916)3.42268832
14Hyperalaninemia (HP:0003348)3.42268832
15Chromsome breakage (HP:0040012)3.42192489
16Abnormality of reticulocytes (HP:0004312)3.41659945
17Chromosomal breakage induced by crosslinking agents (HP:0003221)3.40599468
18Patellar aplasia (HP:0006443)3.36264068
19Chronic hepatic failure (HP:0100626)3.31970185
20Breast hypoplasia (HP:0003187)3.28552311
21Nephronophthisis (HP:0000090)3.18663016
22Abnormality of chromosome stability (HP:0003220)3.18055767
23Aplasia/Hypoplasia of the patella (HP:0006498)3.17615864
24True hermaphroditism (HP:0010459)3.15213396
25Type II lissencephaly (HP:0007260)3.11392546
26Febrile seizures (HP:0002373)3.01898428
27Insomnia (HP:0100785)2.97326895
28Facial hemangioma (HP:0000329)2.91060092
29Oligodactyly (HP:0012165)2.88775847
30Meckel diverticulum (HP:0002245)2.86751621
31Abnormality of the labia minora (HP:0012880)2.86462347
32Gaze-evoked nystagmus (HP:0000640)2.85989577
33Increased nuchal translucency (HP:0010880)2.83961952
34Abnormality of the renal cortex (HP:0011035)2.79336136
35Small intestinal stenosis (HP:0012848)2.76937337
36Duodenal stenosis (HP:0100867)2.76937337
37Pelvic girdle muscle weakness (HP:0003749)2.74954046
38Aplasia/Hypoplasia of the uvula (HP:0010293)2.73071489
39Abnormality of the renal medulla (HP:0100957)2.70339693
40Cafe-au-lait spot (HP:0000957)2.68107105
41Congenital stationary night blindness (HP:0007642)2.64399159
42Abnormality of the ileum (HP:0001549)2.63890492
43Progressive inability to walk (HP:0002505)2.62943148
44Progressive cerebellar ataxia (HP:0002073)2.60652912
45Medial flaring of the eyebrow (HP:0010747)2.60538403
46Prominent nose (HP:0000448)2.57671432
47Abnormality of the preputium (HP:0100587)2.56552350
48Ependymoma (HP:0002888)2.53594340
49Cholelithiasis (HP:0001081)2.51955371
50Ectopic kidney (HP:0000086)2.51899838
51Oligodactyly (hands) (HP:0001180)2.47332234
52Medulloblastoma (HP:0002885)2.46968778
53Atonic seizures (HP:0010819)2.46397878
54Inability to walk (HP:0002540)2.43507833
55Shoulder girdle muscle weakness (HP:0003547)2.43388266
56Tubular atrophy (HP:0000092)2.42581532
57Volvulus (HP:0002580)2.38769598
58Rhabdomyosarcoma (HP:0002859)2.37023855
59Hypoplasia of the capital femoral epiphysis (HP:0003090)2.35276783
60Abnormality of the carotid arteries (HP:0005344)2.34155689
61Cerebellar dysplasia (HP:0007033)2.33908886
62Attenuation of retinal blood vessels (HP:0007843)2.33871664
63Sloping forehead (HP:0000340)2.31708606
64Horizontal nystagmus (HP:0000666)2.29210857
65Absent radius (HP:0003974)2.29017862
66Hyperventilation (HP:0002883)2.28208015
67Renal cortical cysts (HP:0000803)2.27469027
68Oral leukoplakia (HP:0002745)2.26042440
69Atresia of the external auditory canal (HP:0000413)2.25616667
70Broad-based gait (HP:0002136)2.23908989
71Myelodysplasia (HP:0002863)2.22054676
72Aplasia involving forearm bones (HP:0009822)2.21606043
73Absent forearm bone (HP:0003953)2.21606043
74Aplasia/Hypoplasia of the sternum (HP:0006714)2.21257979
75Neoplasm of the pancreas (HP:0002894)2.20729210
76Proximal placement of thumb (HP:0009623)2.20278687
77Degeneration of anterior horn cells (HP:0002398)2.20080251
78Abnormality of the anterior horn cell (HP:0006802)2.20080251
79Rough bone trabeculation (HP:0100670)2.20044478
80Abnormality of the duodenum (HP:0002246)2.19940507
81Diaphragmatic weakness (HP:0009113)2.19226366
82Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.18808126
83Short 4th metacarpal (HP:0010044)2.18808126
84Abnormality of the hip-girdle musculature (HP:0001445)2.18551798
85Abnormality of the musculature of the pelvis (HP:0001469)2.18551798
86Gait imbalance (HP:0002141)2.17444903
87Congenital primary aphakia (HP:0007707)2.17273274
88Deviation of the thumb (HP:0009603)2.16701934
89Acute necrotizing encephalopathy (HP:0006965)2.16081043
90Increased CSF lactate (HP:0002490)2.15961912
91Cervical subluxation (HP:0003308)2.15638061
92Selective tooth agenesis (HP:0001592)2.15552084
93Lipid accumulation in hepatocytes (HP:0006561)2.15550900
94Abnormal gallbladder morphology (HP:0012437)2.14952075
95High pitched voice (HP:0001620)2.14197994
96Abnormal biliary tract physiology (HP:0012439)2.12430347
97Bile duct proliferation (HP:0001408)2.12430347
98Cystic liver disease (HP:0006706)2.09974958
99Abnormality of the pons (HP:0007361)2.09290195
100Dysdiadochokinesis (HP:0002075)2.08086115
101Sclerocornea (HP:0000647)2.07341829
102Aplasia/Hypoplasia of the tongue (HP:0010295)2.06482250
103Long eyelashes (HP:0000527)2.06082511
104Focal motor seizures (HP:0011153)2.05256186
105Acute encephalopathy (HP:0006846)2.03718013
106Hypoplasia of the pons (HP:0012110)2.03625572
107Aplasia/Hypoplasia of the tibia (HP:0005772)2.03398966
108Methylmalonic acidemia (HP:0002912)2.03367083
109Large for gestational age (HP:0001520)2.02306111
110Shallow orbits (HP:0000586)2.02224106
111Increased hepatocellular lipid droplets (HP:0006565)2.00270548
112Tubulointerstitial nephritis (HP:0001970)1.99521065
113Carpal bone hypoplasia (HP:0001498)1.99502253
114Mitochondrial inheritance (HP:0001427)1.99001507
115Nephrogenic diabetes insipidus (HP:0009806)1.98966401
116Pendular nystagmus (HP:0012043)1.97800028
117Basal cell carcinoma (HP:0002671)1.97332090
118Absence seizures (HP:0002121)1.97223592
119Ulnar deviation of the wrist (HP:0003049)1.95865714
120Dialeptic seizures (HP:0011146)1.95503541
121Lissencephaly (HP:0001339)1.95062926
122Microtia (HP:0008551)1.94238433
123Supernumerary spleens (HP:0009799)1.94194702
124Abnormality of dental color (HP:0011073)1.94166515
125Genital tract atresia (HP:0001827)1.93949468
126Polydipsia (HP:0001959)1.93416910
127Abnormal drinking behavior (HP:0030082)1.93416910
128Aplasia/Hypoplasia of the earlobes (HP:0009906)1.92478390
129Progressive macrocephaly (HP:0004481)1.92312638
130Bone marrow hypocellularity (HP:0005528)1.91734593
131Retinal dysplasia (HP:0007973)1.91416895
132Abolished electroretinogram (ERG) (HP:0000550)1.91251087
133Abnormality of chromosome segregation (HP:0002916)1.91167810
134Ureteral duplication (HP:0000073)1.90495693
135Impaired smooth pursuit (HP:0007772)1.89762638
136Postaxial foot polydactyly (HP:0001830)1.89672576
137Breast aplasia (HP:0100783)1.87503924
138Trigonocephaly (HP:0000243)1.87416892
139Small hand (HP:0200055)1.86422908
140Neoplasm of the adrenal cortex (HP:0100641)1.86113396
141Colon cancer (HP:0003003)1.85991086
142Abnormality of the astrocytes (HP:0100707)1.85756013
143Astrocytoma (HP:0009592)1.85756013
144Fair hair (HP:0002286)1.84665638
145Tracheoesophageal fistula (HP:0002575)1.84139621
146Horseshoe kidney (HP:0000085)1.84121772
147Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.83276797
148Short 1st metacarpal (HP:0010034)1.83276797
149Glioma (HP:0009733)1.83210057
150Tetraplegia (HP:0002445)1.83151860
151Premature graying of hair (HP:0002216)1.82742376
152Dynein arm defect of respiratory motile cilia (HP:0012255)1.82067295
153Absent/shortened dynein arms (HP:0200106)1.82067295
154Duplicated collecting system (HP:0000081)1.81825919
155Increased serum lactate (HP:0002151)1.81447335
156Vaginal atresia (HP:0000148)1.81287422
157Reticulocytopenia (HP:0001896)1.81221790
158Cerebral hypomyelination (HP:0006808)1.81134943
159Anencephaly (HP:0002323)1.80977602
160Protruding tongue (HP:0010808)1.80784271
161Broad palm (HP:0001169)1.79689597
162Abnormality of ocular smooth pursuit (HP:0000617)1.78784187
163Neoplasm of striated muscle (HP:0009728)1.78203082
164Heterotopia (HP:0002282)1.77221159
165Squamous cell carcinoma (HP:0002860)1.76802872
166Aplasia/Hypoplasia of the breasts (HP:0010311)1.76643627
167Hyperbilirubinemia (HP:0002904)1.75258439
168Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.75222028
169Absent epiphyses (HP:0010577)1.75222028
170Abnormal mitochondria in muscle tissue (HP:0008316)1.73784812
171Hypothermia (HP:0002045)1.72908486
172Astigmatism (HP:0000483)1.72303282
173Clubbing of toes (HP:0100760)1.71870406
174Preaxial hand polydactyly (HP:0001177)1.71783788
175Abnormality of serum amino acid levels (HP:0003112)1.71283826
176Furrowed tongue (HP:0000221)1.71183667
177Dandy-Walker malformation (HP:0001305)1.69463456
178Optic nerve hypoplasia (HP:0000609)1.68810467
179Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.68230449
180Optic disc pallor (HP:0000543)1.66783019
181Congenital hepatic fibrosis (HP:0002612)1.66696430

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CCNB14.93677803
2CDC74.84286941
3FRK4.48342517
4BUB13.68966070
5WEE13.55731662
6EIF2AK13.43528926
7NEK23.29286641
8MAP4K22.92716303
9BMPR1B2.71371215
10TLK12.70058408
11PLK42.42072178
12WNK42.28257795
13TTK2.27872033
14BRSK22.08908235
15ADRBK22.07610808
16CDK122.06779643
17EEF2K2.05333862
18WNK31.99758528
19NEK11.99617481
20TRIM281.90266174
21BRSK11.87466875
22PLK11.87302021
23STK41.86930372
24LATS11.81824497
25AURKB1.73747151
26CHEK21.73223590
27PLK31.67341135
28STK391.66398348
29PINK11.62511145
30GRK11.60075684
31INSRR1.59610944
32SRPK11.57794752
33CDK41.53851681
34ATR1.52578874
35TNIK1.51919675
36VRK11.51099256
37DYRK31.50504217
38CASK1.38890613
39MAP3K41.38583921
40STK31.34556549
41STK101.33809107
42ZAK1.33661783
43CHEK11.31948059
44MAP3K81.30178193
45TAOK31.28505229
46ACVR1B1.25456580
47SCYL21.24262576
48AURKA1.21492679
49MAPK131.21463692
50RPS6KA41.20408619
51CDK71.19678898
52CAMKK21.18290639
53RPS6KB21.17617482
54OXSR11.17512799
55TSSK61.15912128
56MAP3K121.15255500
57MKNK21.15173188
58TAF11.14933384
59MAP3K101.13608484
60ATM1.13112032
61MKNK11.12615481
62MST41.07866399
63ALK1.06324082
64STK161.06175498
65CSNK1G11.04106191
66CDK61.03233866
67CSNK1G31.01240425
68CDK20.99802524
69BRD40.98523995
70PLK20.97741159
71PIM10.97072904
72TGFBR10.96464842
73CSNK1G20.95121383
74CDK10.88822097
75TXK0.88278506
76NME20.87793269
77MAP3K30.87568723
78NTRK30.85385884
79CSNK1A1L0.83190242
80PBK0.82556122
81MELK0.82505984
82PRKCG0.82385334
83PASK0.82079304
84VRK20.79946003
85BCR0.79529133
86PAK40.70808382
87PRKCE0.70367993
88TESK20.69791683
89ERBB20.69297863
90DYRK20.69110584
91EIF2AK30.68160677
92CDK30.67741566
93FGFR20.66934863
94PAK30.66469099
95BCKDK0.66007374
96RPS6KA50.64135926
97EIF2AK20.63407085
98PTK60.60961971
99NEK90.60620135
100ADRBK10.59001306
101PNCK0.58269683
102PRKDC0.57935866
103TRIB30.57321266
104GRK50.55357412
105MUSK0.55269392
106TRPM70.54495108
107MTOR0.53517966
108DAPK20.52547440
109MAP2K70.52281007
110PIK3CA0.51741794
111ERBB30.51503481
112RIPK10.50359876
113CSNK1A10.48500595
114PRKCI0.48106140
115NUAK10.47294092
116NLK0.46496494
117MAPKAPK30.45014919
118PRKAA10.44253868
119PAK10.43355360
120FLT30.43155041
121CAMK2A0.43129487
122STK380.41710998
123MAPK140.40351848
124MAPK110.39611569
125CSNK1D0.39246411
126YES10.39234044
127CDK150.38652165
128NME10.37991509
129TIE10.37317673
130PHKG20.37229937
131PHKG10.37229937
132CSNK2A20.37017947
133PDK30.36341301
134PDK40.36341301
135DYRK1B0.35715380
136PRKG10.35573114
137GSK3B0.35124041
138AKT20.34809712
139CSNK2A10.34551868
140CDK11A0.33904790
141MAPKAPK50.33129711
142MAPK90.32971069
143CDK180.31724567
144DYRK1A0.31721038
145MARK30.31319163
146AKT10.31216692
147LRRK20.30348257
148MAPK10.29047370
149TESK10.28739028
150PKN20.28408675
151CDK140.28380480
152STK38L0.26382286
153CSNK1E0.26034306
154SGK30.25327695
155WNK10.25075073
156CAMK1D0.24585636
157SGK20.24503306
158CDK90.23173357
159AKT30.21950590

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.29127297
2Mismatch repair_Homo sapiens_hsa034303.92807339
3Cell cycle_Homo sapiens_hsa041103.77172803
4Base excision repair_Homo sapiens_hsa034103.18740965
5Systemic lupus erythematosus_Homo sapiens_hsa053223.13311866
6RNA transport_Homo sapiens_hsa030133.12539298
7Spliceosome_Homo sapiens_hsa030403.11358163
8Nitrogen metabolism_Homo sapiens_hsa009103.06007197
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.97800995
10Vitamin B6 metabolism_Homo sapiens_hsa007502.95996372
11One carbon pool by folate_Homo sapiens_hsa006702.93801812
12Nucleotide excision repair_Homo sapiens_hsa034202.62897140
13Homologous recombination_Homo sapiens_hsa034402.61919229
14Fanconi anemia pathway_Homo sapiens_hsa034602.54493162
15Protein export_Homo sapiens_hsa030602.17417014
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.15227675
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.06034625
18p53 signaling pathway_Homo sapiens_hsa041152.03750741
19mRNA surveillance pathway_Homo sapiens_hsa030152.01456555
20Oxidative phosphorylation_Homo sapiens_hsa001901.97121546
21Nicotine addiction_Homo sapiens_hsa050331.96141858
22Phototransduction_Homo sapiens_hsa047441.94927788
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.86011041
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.84641820
25Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.83481668
26RNA polymerase_Homo sapiens_hsa030201.82167705
27Butanoate metabolism_Homo sapiens_hsa006501.81987612
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.78080412
29Pyrimidine metabolism_Homo sapiens_hsa002401.75169871
30Linoleic acid metabolism_Homo sapiens_hsa005911.74087657
31Oocyte meiosis_Homo sapiens_hsa041141.73109548
32Non-homologous end-joining_Homo sapiens_hsa034501.70383806
33RNA degradation_Homo sapiens_hsa030181.70333503
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.63150917
35Propanoate metabolism_Homo sapiens_hsa006401.60883112
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.60441244
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.60075460
38Parkinsons disease_Homo sapiens_hsa050121.58193311
39Alcoholism_Homo sapiens_hsa050341.55469812
40Taste transduction_Homo sapiens_hsa047421.54575351
41Viral carcinogenesis_Homo sapiens_hsa052031.52149752
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.51267313
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.50416074
44Basal transcription factors_Homo sapiens_hsa030221.47729118
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.46808197
46Ether lipid metabolism_Homo sapiens_hsa005651.41816265
47Caffeine metabolism_Homo sapiens_hsa002321.37422127
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35714209
49Selenocompound metabolism_Homo sapiens_hsa004501.35038987
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.34324344
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.32915011
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.31364245
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.28482798
54Proteasome_Homo sapiens_hsa030501.27970017
55Huntingtons disease_Homo sapiens_hsa050161.26419437
56Tryptophan metabolism_Homo sapiens_hsa003801.22796629
57Olfactory transduction_Homo sapiens_hsa047401.09014035
58Morphine addiction_Homo sapiens_hsa050321.04507242
59Cysteine and methionine metabolism_Homo sapiens_hsa002701.03901813
60GABAergic synapse_Homo sapiens_hsa047271.00125557
61Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.99667737
62Regulation of autophagy_Homo sapiens_hsa041400.99186787
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.99024786
64Small cell lung cancer_Homo sapiens_hsa052220.96478970
65Herpes simplex infection_Homo sapiens_hsa051680.96435522
66HTLV-I infection_Homo sapiens_hsa051660.94556569
67MicroRNAs in cancer_Homo sapiens_hsa052060.93471856
68Alzheimers disease_Homo sapiens_hsa050100.92832887
69Epstein-Barr virus infection_Homo sapiens_hsa051690.91681596
70Purine metabolism_Homo sapiens_hsa002300.89957264
71Glutamatergic synapse_Homo sapiens_hsa047240.89438847
72Serotonergic synapse_Homo sapiens_hsa047260.84636630
73Peroxisome_Homo sapiens_hsa041460.83931709
74Pentose phosphate pathway_Homo sapiens_hsa000300.81293098
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79418087
76Cardiac muscle contraction_Homo sapiens_hsa042600.78000133
77Biosynthesis of amino acids_Homo sapiens_hsa012300.77553234
78Steroid biosynthesis_Homo sapiens_hsa001000.73849315
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72416365
80Sulfur metabolism_Homo sapiens_hsa009200.72356148
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72300330
82Chronic myeloid leukemia_Homo sapiens_hsa052200.72133020
83ABC transporters_Homo sapiens_hsa020100.72054365
84Circadian entrainment_Homo sapiens_hsa047130.70999495
85Retinol metabolism_Homo sapiens_hsa008300.70949095
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70847458
87Apoptosis_Homo sapiens_hsa042100.70821392
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67025999
89Antigen processing and presentation_Homo sapiens_hsa046120.66940360
90Metabolic pathways_Homo sapiens_hsa011000.66913730
91Insulin secretion_Homo sapiens_hsa049110.64723364
92mTOR signaling pathway_Homo sapiens_hsa041500.64173723
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.63757447
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62002724
95FoxO signaling pathway_Homo sapiens_hsa040680.61842011
96Lysine degradation_Homo sapiens_hsa003100.61619969
97Hepatitis B_Homo sapiens_hsa051610.60942616
98Ribosome_Homo sapiens_hsa030100.58831974
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.58469805
100Hippo signaling pathway_Homo sapiens_hsa043900.57230577
101Folate biosynthesis_Homo sapiens_hsa007900.56806577
102Non-small cell lung cancer_Homo sapiens_hsa052230.54496213
103Pyruvate metabolism_Homo sapiens_hsa006200.52630284
104TGF-beta signaling pathway_Homo sapiens_hsa043500.52302574
105Glycerolipid metabolism_Homo sapiens_hsa005610.51850439
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50572875
107Sulfur relay system_Homo sapiens_hsa041220.50567515
108Fatty acid elongation_Homo sapiens_hsa000620.50205434
109Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50152952
110Dopaminergic synapse_Homo sapiens_hsa047280.49900398
111Chemical carcinogenesis_Homo sapiens_hsa052040.49898254
112Vitamin digestion and absorption_Homo sapiens_hsa049770.48438648
113Prostate cancer_Homo sapiens_hsa052150.47042271
114Fatty acid biosynthesis_Homo sapiens_hsa000610.46611075
115Bladder cancer_Homo sapiens_hsa052190.46486567
116Calcium signaling pathway_Homo sapiens_hsa040200.46045860
117Fatty acid metabolism_Homo sapiens_hsa012120.45812811
118Long-term depression_Homo sapiens_hsa047300.44883660
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44050197
120Fat digestion and absorption_Homo sapiens_hsa049750.43539851
121Colorectal cancer_Homo sapiens_hsa052100.43439668
122Thyroid cancer_Homo sapiens_hsa052160.42448842
123Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41909287
124Mineral absorption_Homo sapiens_hsa049780.41230300
125Arachidonic acid metabolism_Homo sapiens_hsa005900.40808056
126Cyanoamino acid metabolism_Homo sapiens_hsa004600.38428670
127Salivary secretion_Homo sapiens_hsa049700.38358625
128Inositol phosphate metabolism_Homo sapiens_hsa005620.38206153
129beta-Alanine metabolism_Homo sapiens_hsa004100.37114383
130Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.36009075
131Wnt signaling pathway_Homo sapiens_hsa043100.35835409
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.34962261
133Central carbon metabolism in cancer_Homo sapiens_hsa052300.34647299
134Pancreatic cancer_Homo sapiens_hsa052120.33627500
135Hedgehog signaling pathway_Homo sapiens_hsa043400.32696931
136Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31401240
137Carbon metabolism_Homo sapiens_hsa012000.30887776
138Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30282707
139Proteoglycans in cancer_Homo sapiens_hsa052050.29782967
140AMPK signaling pathway_Homo sapiens_hsa041520.28803315
141Long-term potentiation_Homo sapiens_hsa047200.27891918
142Basal cell carcinoma_Homo sapiens_hsa052170.26297945
143Glutathione metabolism_Homo sapiens_hsa004800.24251726
144HIF-1 signaling pathway_Homo sapiens_hsa040660.22954807
145Thyroid hormone synthesis_Homo sapiens_hsa049180.20979461
146Legionellosis_Homo sapiens_hsa051340.20582791
147Notch signaling pathway_Homo sapiens_hsa043300.19272118
148Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.18876547
149Glioma_Homo sapiens_hsa052140.18379740
150Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.18351773
151Drug metabolism - other enzymes_Homo sapiens_hsa009830.18273915
152Measles_Homo sapiens_hsa051620.16472344
153Pathways in cancer_Homo sapiens_hsa052000.15053877
154Phosphatidylinositol signaling system_Homo sapiens_hsa040700.14716705
155Acute myeloid leukemia_Homo sapiens_hsa052210.14557769
156Estrogen signaling pathway_Homo sapiens_hsa049150.13249887
157Hematopoietic cell lineage_Homo sapiens_hsa046400.12041263
158Circadian rhythm_Homo sapiens_hsa047100.10412935
159Endometrial cancer_Homo sapiens_hsa052130.10331333
160Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.08792248
161Melanoma_Homo sapiens_hsa052180.08625498
162Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.08154377
163Type II diabetes mellitus_Homo sapiens_hsa049300.07884087
164Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.07559504
165Glucagon signaling pathway_Homo sapiens_hsa049220.07559254

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