CEP85

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to the centrosome-associated family of proteins. The centrosome is a subcellular organelle in the animal cell that functions as a microtubule organizing center and is involved in cell-cycle progression. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic chromosome condensation (GO:0007076)6.77680663
2nuclear pore complex assembly (GO:0051292)6.77442247
3nuclear pore organization (GO:0006999)6.01894915
4DNA unwinding involved in DNA replication (GO:0006268)5.73909342
5antigen processing and presentation of endogenous antigen (GO:0019883)5.71239411
6mitotic sister chromatid segregation (GO:0000070)5.23179437
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.15893342
8antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.15893342
9sister chromatid segregation (GO:0000819)5.09527016
10pore complex assembly (GO:0046931)4.96153346
11DNA strand elongation involved in DNA replication (GO:0006271)4.90422779
12protein localization to chromosome, centromeric region (GO:0071459)4.89056036
13protein localization to kinetochore (GO:0034501)4.88374882
14DNA strand elongation (GO:0022616)4.75867371
15DNA replication initiation (GO:0006270)4.69792370
16DNA topological change (GO:0006265)4.62164525
17mitotic metaphase plate congression (GO:0007080)4.58668362
18telomere maintenance via semi-conservative replication (GO:0032201)4.43259546
19mitotic nuclear envelope disassembly (GO:0007077)4.40790104
20mitotic sister chromatid cohesion (GO:0007064)4.37397882
21DNA replication checkpoint (GO:0000076)4.28123121
22regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.27963100
23chromosome condensation (GO:0030261)4.27256077
24hepatocyte apoptotic process (GO:0097284)4.26895051
25membrane disassembly (GO:0030397)4.16760589
26nuclear envelope disassembly (GO:0051081)4.16760589
27positive regulation of gamma-delta T cell activation (GO:0046645)4.10121371
28regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.03294879
29regulation of mitotic spindle organization (GO:0060236)4.01256936
30metaphase plate congression (GO:0051310)3.91057852
31telomere maintenance via recombination (GO:0000722)3.84001750
32IMP metabolic process (GO:0046040)3.83452274
33regulation of spindle organization (GO:0090224)3.82808024
34DNA packaging (GO:0006323)3.81432701
35mitotic recombination (GO:0006312)3.80050637
36regulation of translational fidelity (GO:0006450)3.77292354
37regulation of RNA export from nucleus (GO:0046831)3.75783512
38positive regulation of chromosome segregation (GO:0051984)3.75245201
39IMP biosynthetic process (GO:0006188)3.73478581
40positive regulation of B cell differentiation (GO:0045579)3.71946270
41meiotic chromosome segregation (GO:0045132)3.70421977
42kinetochore organization (GO:0051383)3.67513037
43regulation of histone H3-K9 methylation (GO:0051570)3.59398946
44pyrimidine ribonucleoside catabolic process (GO:0046133)3.58587195
45chromosome segregation (GO:0007059)3.56621032
46regulation of chromosome segregation (GO:0051983)3.56330668
47DNA conformation change (GO:0071103)3.55895748
48cytidine deamination (GO:0009972)3.54148873
49cytidine metabolic process (GO:0046087)3.54148873
50cytidine catabolic process (GO:0006216)3.54148873
51establishment of chromosome localization (GO:0051303)3.52292279
52DNA duplex unwinding (GO:0032508)3.52245349
53DNA synthesis involved in DNA repair (GO:0000731)3.48689608
54negative regulation of histone methylation (GO:0031061)3.48034088
55B cell receptor signaling pathway (GO:0050853)3.46790891
56formation of translation preinitiation complex (GO:0001731)3.46125845
57NIK/NF-kappaB signaling (GO:0038061)3.41949248
58negative regulation of chromosome segregation (GO:0051985)3.41304256
59DNA geometric change (GO:0032392)3.39723093
60CENP-A containing nucleosome assembly (GO:0034080)3.39242492
61actin-myosin filament sliding (GO:0033275)3.37948960
62muscle filament sliding (GO:0030049)3.37948960
63protein localization to chromosome (GO:0034502)3.37575692
64DNA ligation (GO:0006266)3.35228093
65nuclear envelope organization (GO:0006998)3.33567748
66regulation of gamma-delta T cell differentiation (GO:0045586)3.32369997
67chromatin remodeling at centromere (GO:0031055)3.32204690
68spindle checkpoint (GO:0031577)3.31338509
69positive regulation of antigen processing and presentation (GO:0002579)3.28611980
70establishment of integrated proviral latency (GO:0075713)3.28448558
71regulation of sister chromatid cohesion (GO:0007063)3.28132605
72negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.26683674
73negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.26683674
74negative regulation of mitotic sister chromatid segregation (GO:0033048)3.26683674
75negative regulation of mitotic sister chromatid separation (GO:2000816)3.26683674
76negative regulation of sister chromatid segregation (GO:0033046)3.26683674
77mitotic spindle checkpoint (GO:0071174)3.22900900
78nucleotide-excision repair, DNA gap filling (GO:0006297)3.22732074
79mitotic spindle assembly checkpoint (GO:0007094)3.21352514
80heterochromatin organization (GO:0070828)3.20477357
81regulation of mitotic sister chromatid separation (GO:0010965)3.18354029
82regulation of mitotic sister chromatid segregation (GO:0033047)3.18354029
83regulation of sister chromatid segregation (GO:0033045)3.18354029
84spindle assembly checkpoint (GO:0071173)3.17657241
85DNA replication-independent nucleosome organization (GO:0034724)3.15924061
86DNA replication-independent nucleosome assembly (GO:0006336)3.15924061
87regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.15113080
88regulation of mitotic metaphase/anaphase transition (GO:0030071)3.15113080
89chromatin assembly or disassembly (GO:0006333)3.12655377
90regulation of centriole replication (GO:0046599)3.12268755
91regulation of superoxide anion generation (GO:0032928)3.10960360
92regulation of B cell differentiation (GO:0045577)3.09639863
93valine metabolic process (GO:0006573)3.09513126
94regulation of gamma-delta T cell activation (GO:0046643)3.08529233
95regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.08161080
96regulation of centrosome cycle (GO:0046605)3.06970024
97regulation of histone H3-K4 methylation (GO:0051569)3.04861901
98positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.03832537
99positive regulation of mitotic sister chromatid separation (GO:1901970)3.03832537
100positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.03832537
101DNA replication-dependent nucleosome assembly (GO:0006335)3.03714960
102DNA replication-dependent nucleosome organization (GO:0034723)3.03714960
103non-recombinational repair (GO:0000726)3.03550142
104double-strand break repair via nonhomologous end joining (GO:0006303)3.03550142
105antigen processing and presentation via MHC class Ib (GO:0002475)2.99298363
106microtubule depolymerization (GO:0007019)2.98091117
107attachment of spindle microtubules to kinetochore (GO:0008608)2.96822794
108telomere maintenance via telomere lengthening (GO:0010833)2.96765904
109negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.94781585
110regulation of nucleobase-containing compound transport (GO:0032239)2.94653087
111regulation of DNA endoreduplication (GO:0032875)2.93395754
112negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.92011529
113peptide catabolic process (GO:0043171)2.91260085
114protein complex localization (GO:0031503)2.90114943
115negative regulation of cell cycle G2/M phase transition (GO:1902750)2.88886020
116chromatin assembly (GO:0031497)2.88120771
117folic acid-containing compound biosynthetic process (GO:0009396)2.86951661
118purine nucleobase biosynthetic process (GO:0009113)2.83991956
119immunoglobulin mediated immune response (GO:0016064)2.83192418
120histone exchange (GO:0043486)2.81619073
121ATP-dependent chromatin remodeling (GO:0043044)2.81125065
122mitotic cell cycle (GO:0000278)2.80707913
123negative regulation of phagocytosis (GO:0050765)2.80130041
124neutrophil activation involved in immune response (GO:0002283)2.76359438
125regulation of interferon-beta biosynthetic process (GO:0045357)2.75066821
126UDP-N-acetylglucosamine metabolic process (GO:0006047)2.74272776
127cellular response to zinc ion (GO:0071294)2.72465331
128myeloid dendritic cell activation (GO:0001773)2.71661367
129dendritic cell chemotaxis (GO:0002407)2.69561515
130regulation of antigen processing and presentation (GO:0002577)2.69257441
131positive regulation of Cdc42 GTPase activity (GO:0043089)2.67878905
132pentose-phosphate shunt (GO:0006098)2.67819448
133drug transmembrane transport (GO:0006855)2.67697986
134cysteine metabolic process (GO:0006534)2.67408560
135fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.66491763
136regulation of respiratory burst (GO:0060263)2.66423154
137neutrophil activation (GO:0042119)2.65529977
138regulation of B cell receptor signaling pathway (GO:0050855)2.62551391
139cellular extravasation (GO:0045123)2.52724962
140leukotriene biosynthetic process (GO:0019370)2.52140844
141urea cycle (GO:0000050)2.50703541
142urea metabolic process (GO:0019627)2.50703541
143mannose metabolic process (GO:0006013)2.49399849
144ribosomal small subunit assembly (GO:0000028)2.47514910
145positive regulation of interferon-alpha production (GO:0032727)2.46732582
146regulation of interleukin-12 biosynthetic process (GO:0045075)2.46015477
147indole-containing compound catabolic process (GO:0042436)2.44238371
148indolalkylamine catabolic process (GO:0046218)2.44238371
149tryptophan catabolic process (GO:0006569)2.44238371
150respiratory burst (GO:0045730)2.43143114
151regulation of interferon-alpha production (GO:0032647)2.42652507
152dendritic cell migration (GO:0036336)2.42598609
153antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.41566761
154regulation of dendritic cell antigen processing and presentation (GO:0002604)2.41469127
155cellular response to exogenous dsRNA (GO:0071360)2.41181738
156granulocyte activation (GO:0036230)2.40678857
157drug transport (GO:0015893)2.39587271
158myeloid dendritic cell differentiation (GO:0043011)2.39393873
159serine transport (GO:0032329)2.39270384
160regulation of lipoprotein particle clearance (GO:0010984)2.38695375
161L-phenylalanine metabolic process (GO:0006558)2.36841670
162erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.36841670
163B cell mediated immunity (GO:0019724)2.36728397
164negative regulation of B cell proliferation (GO:0030889)2.35942604
165NADPH regeneration (GO:0006740)2.33772101
166aromatic amino acid family catabolic process (GO:0009074)2.32232108
167sulfur amino acid catabolic process (GO:0000098)2.31649781
168leukotriene metabolic process (GO:0006691)2.29952337
169intestinal cholesterol absorption (GO:0030299)2.29057829
170pinocytosis (GO:0006907)2.28976448
171regulation of superoxide metabolic process (GO:0090322)2.28141206
172Arp2/3 complex-mediated actin nucleation (GO:0034314)2.27901194
173response to protozoan (GO:0001562)2.27824997
174tryptophan metabolic process (GO:0006568)2.27579310
175erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.26774582
176L-phenylalanine catabolic process (GO:0006559)2.26774582
177complement activation, classical pathway (GO:0006958)2.26525467
178dendritic cell differentiation (GO:0097028)2.24559342
179nitrogen cycle metabolic process (GO:0071941)2.24335314
180positive regulation of granulocyte chemotaxis (GO:0071624)2.24179389
181germinal center formation (GO:0002467)2.23363242
182regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.22611764
183regulation of B cell apoptotic process (GO:0002902)2.22332807
184interferon-gamma-mediated signaling pathway (GO:0060333)2.21592738
185homocysteine metabolic process (GO:0050667)2.20934841
186response to type I interferon (GO:0034340)2.20924664
187urate metabolic process (GO:0046415)2.20510323
188positive thymic T cell selection (GO:0045059)2.20184413
189tolerance induction (GO:0002507)2.19690740
190hypotonic response (GO:0006971)2.19297564
191response to nitrosative stress (GO:0051409)2.17210752
192positive regulation of respiratory burst (GO:0060267)2.16169029
193regulation of B cell proliferation (GO:0030888)2.15613251
194regulation of Cdc42 GTPase activity (GO:0043088)2.14610489
195natural killer cell mediated immunity (GO:0002228)2.13661491
196natural killer cell mediated cytotoxicity (GO:0042267)2.13661491
197regulation of RIG-I signaling pathway (GO:0039535)2.13267919
198cellular modified amino acid catabolic process (GO:0042219)2.13198254
199positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.12977219
200type I interferon signaling pathway (GO:0060337)2.12942014

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.24673578
2E2F7_22180533_ChIP-Seq_HELA_Human3.89968813
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.60993110
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.22286686
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.12451357
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.07019805
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.95895427
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.79142706
9STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.77469012
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.63331710
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.62975590
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.59819351
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.58621806
14PPARA_22158963_ChIP-Seq_LIVER_Mouse2.57157945
15KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.54121657
16MYC_22102868_ChIP-Seq_BL_Human2.52716297
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.51764832
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.50950764
19RXR_22158963_ChIP-Seq_LIVER_Mouse2.44791843
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.39107852
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.36530133
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.35386839
23GATA1_22025678_ChIP-Seq_K562_Human2.31998844
24IRF8_27001747_Chip-Seq_BMDM_Mouse2.30178511
25MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.28948819
26VDR_21846776_ChIP-Seq_THP-1_Human2.24251252
27STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.21425864
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.19682844
29FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.16680880
30FOXM1_23109430_ChIP-Seq_U2OS_Human2.16161377
31MYB_21317192_ChIP-Seq_ERMYB_Mouse2.14476942
32XRN2_22483619_ChIP-Seq_HELA_Human2.13207845
33EGR1_23403033_ChIP-Seq_LIVER_Mouse2.07178109
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.06107300
35SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.06051893
36NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.99945843
37NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.99476031
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.99136418
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.95306375
40YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.94787745
41STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.91179861
42DCP1A_22483619_ChIP-Seq_HELA_Human1.90551851
43ETS1_20019798_ChIP-Seq_JURKAT_Human1.89145557
44LXR_22158963_ChIP-Seq_LIVER_Mouse1.88661032
45JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.86721043
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.86649344
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.85690553
48EST1_17652178_ChIP-ChIP_JURKAT_Human1.85183854
49IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.84656798
50ZFX_18555785_ChIP-Seq_MESCs_Mouse1.83338907
51MYB_26560356_Chip-Seq_TH2_Human1.83270368
52TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.81855043
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79455773
54CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.78680323
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.78507408
56MAF_26560356_Chip-Seq_TH1_Human1.76652302
57E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.75575512
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.75195167
59MYB_26560356_Chip-Seq_TH1_Human1.74375664
60CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.73565710
61VDR_24763502_ChIP-Seq_THP-1_Human1.72498640
62TTF2_22483619_ChIP-Seq_HELA_Human1.72480386
63MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.70144362
64SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.69082739
65STAT4_19710469_ChIP-ChIP_TH1__Mouse1.68925427
66SPI1_23547873_ChIP-Seq_NB4_Human1.66819813
67PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.64129234
68STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.63415682
69CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.62754026
70RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.62185572
71SCL_19346495_ChIP-Seq_HPC-7_Human1.57901378
72CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.57633629
73E2F1_18555785_ChIP-Seq_MESCs_Mouse1.57192241
74KDM5A_27292631_Chip-Seq_BREAST_Human1.55735115
75UTX_26944678_Chip-Seq_JUKART_Human1.55270221
76FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.54223753
77CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.52970562
78PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.49431708
79FOXP3_21729870_ChIP-Seq_TREG_Human1.48149915
80RUNX1_22412390_ChIP-Seq_EML_Mouse1.46651406
81HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.45257210
82TCF7_22412390_ChIP-Seq_EML_Mouse1.43780148
83FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.42294144
84NANOG_18555785_ChIP-Seq_MESCs_Mouse1.40728665
85GABP_19822575_ChIP-Seq_HepG2_Human1.39147615
86CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.38419076
87FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.38394878
88SOX2_27498859_Chip-Seq_STOMACH_Mouse1.35897437
89DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.35000446
90GATA2_22383799_ChIP-Seq_G1ME_Mouse1.34802501
91ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.34270868
92RUNX_20019798_ChIP-Seq_JUKART_Human1.33881659
93KLF4_18555785_ChIP-Seq_MESCs_Mouse1.33586752
94BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.33314398
95CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.33265442
96* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.32883745
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.32440273
98GABP_17652178_ChIP-ChIP_JURKAT_Human1.30462133
99ESR1_21235772_ChIP-Seq_MCF-7_Human1.30449288
100TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.28229358
101GATA6_25053715_ChIP-Seq_YYC3_Human1.26977494
102Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.24546827
103GATA1_22383799_ChIP-Seq_G1ME_Mouse1.23968673
104AR_21909140_ChIP-Seq_LNCAP_Human1.22364192
105CDX2_20551321_ChIP-Seq_CACO-2_Human1.19901147
106GATA4_25053715_ChIP-Seq_YYC3_Human1.18388618
107SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18210104
108ELK1_19687146_ChIP-ChIP_HELA_Human1.17709333
109VDR_23849224_ChIP-Seq_CD4+_Human1.17498899
110RBPJ_22232070_ChIP-Seq_NCS_Mouse1.17092845
111ELF1_17652178_ChIP-ChIP_JURKAT_Human1.16605455
112EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.16290763
113YY1_21170310_ChIP-Seq_MESCs_Mouse1.15865018
114NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.15828930
115E2F4_17652178_ChIP-ChIP_JURKAT_Human1.14900143
116KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14725248
117TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12861812
118FOXO3_23340844_ChIP-Seq_DLD1_Human1.12173619
119FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.11202782
120FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.10694757
121PU_27001747_Chip-Seq_BMDM_Mouse1.10489536
122PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10376036
123SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.10138495
124E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.10049561
125NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.08511202
126CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08027849
127TFEB_21752829_ChIP-Seq_HELA_Human1.07428896
128LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.07104275
129MAF_26560356_Chip-Seq_TH2_Human1.05840089
130SALL1_21062744_ChIP-ChIP_HESCs_Human1.04019723
131GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.03773620
132ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03575031
133DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03329221
134KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.02725966
135ZNF263_19887448_ChIP-Seq_K562_Human1.02577246
136TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02082976
137SPI1_23127762_ChIP-Seq_K562_Human1.01926734
138FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.98539432
139GATA3_27048872_Chip-Seq_THYMUS_Human0.98258209
140TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97089053
141MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.96595894
142SRF_21415370_ChIP-Seq_HL-1_Mouse0.96449453
143HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.95808047
144STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95608246
145CIITA_25753668_ChIP-Seq_RAJI_Human0.94932173
146PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94655872
147E2F1_21310950_ChIP-Seq_MCF-7_Human0.94493145
148NANOG_21062744_ChIP-ChIP_HESCs_Human0.94394527
149PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.93958523
150NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.93599834
151CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93066931
152CHD1_26751641_Chip-Seq_LNCaP_Human0.91826394
153GATA2_21666600_ChIP-Seq_HMVEC_Human0.91230306
154NCOR1_26117541_ChIP-Seq_K562_Human0.90894872
155SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.90860472
156GATA4_21415370_ChIP-Seq_HL-1_Mouse0.90508368
157GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90122969
158HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89450242
159ELK3_25401928_ChIP-Seq_HUVEC_Human0.88368966
160ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.87995086
161KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.87733381
162SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87324489
163SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.87146366
164ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.79395134
165SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.78077137
166POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.75967959
167SOX17_20123909_ChIP-Seq_XEN_Mouse0.75447324
168TP63_19390658_ChIP-ChIP_HaCaT_Human0.75265592
169TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.75253026
170SOX2_18555785_ChIP-Seq_MESCs_Mouse0.74509173
171TBX5_21415370_ChIP-Seq_HL-1_Mouse0.74482504
172ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.74337451
173KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.73530299
174SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.72643979
175PKCTHETA_26484144_Chip-Seq_BREAST_Human0.70683926
176TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.70115646

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.40076335
2MP0003111_abnormal_nucleus_morphology4.34492286
3MP0001835_abnormal_antigen_presentation3.52006089
4MP0004957_abnormal_blastocyst_morpholog3.50484377
5MP0003077_abnormal_cell_cycle3.43542147
6MP0008058_abnormal_DNA_repair3.17731014
7MP0003300_gastrointestinal_ulcer3.13928204
8MP0000685_abnormal_immune_system2.79072925
9MP0003646_muscle_fatigue2.77794465
10MP0004145_abnormal_muscle_electrophysio2.69865901
11MP0002139_abnormal_hepatobiliary_system2.68929048
12MP0005451_abnormal_body_composition2.60599795
13MP0002138_abnormal_hepatobiliary_system2.60313580
14MP0000749_muscle_degeneration2.56058193
15MP0000751_myopathy2.55588770
16MP0005360_urolithiasis2.54158663
17MP0008932_abnormal_embryonic_tissue2.47908234
18MP0004233_abnormal_muscle_weight2.43540176
19MP0001873_stomach_inflammation2.39031344
20MP0002166_altered_tumor_susceptibility2.38313861
21MP0005387_immune_system_phenotype2.37458972
22MP0001790_abnormal_immune_system2.37458972
23MP0001800_abnormal_humoral_immune2.34782703
24MP0001730_embryonic_growth_arrest2.26850734
25MP0010155_abnormal_intestine_physiology2.08968291
26MP0002269_muscular_atrophy2.04874897
27MP0009697_abnormal_copulation1.99397811
28MP0008007_abnormal_cellular_replicative1.98601426
29MP0002254_reproductive_system_inflammat1.97231617
30MP0001666_abnormal_nutrient_absorption1.96240061
31MP0002452_abnormal_antigen_presenting1.95104176
32MP0003436_decreased_susceptibility_to1.93864967
33MP0003718_maternal_effect1.93370991
34MP0004036_abnormal_muscle_relaxation1.91951869
35MP0002396_abnormal_hematopoietic_system1.90736872
36MP0009785_altered_susceptibility_to1.90318223
37MP0005365_abnormal_bile_salt1.89831209
38MP0000350_abnormal_cell_proliferation1.89522708
39MP0005025_abnormal_response_to1.89390814
40MP0010234_abnormal_vibrissa_follicle1.85757954
41MP0004087_abnormal_muscle_fiber1.85217253
42MP0005085_abnormal_gallbladder_physiolo1.82863314
43MP0005671_abnormal_response_to1.82461806
44MP0000747_muscle_weakness1.82210791
45MP0005000_abnormal_immune_tolerance1.80760192
46MP0005310_abnormal_salivary_gland1.79443253
47MP0005380_embryogenesis_phenotype1.75870057
48MP0001672_abnormal_embryogenesis/_devel1.75870057
49MP0002006_tumorigenesis1.73758739
50MP0002723_abnormal_immune_serum1.73376541
51MP0001853_heart_inflammation1.70752893
52MP0002106_abnormal_muscle_physiology1.68202968
53MP0000759_abnormal_skeletal_muscle1.67702526
54MP0004084_abnormal_cardiac_muscle1.67595971
55MP0002148_abnormal_hypersensitivity_rea1.67431870
56MP0002420_abnormal_adaptive_immunity1.66799852
57MP0009672_abnormal_birth_weight1.65599826
58MP0001819_abnormal_immune_cell1.64931103
59MP0003866_abnormal_defecation1.64651489
60MP0001697_abnormal_embryo_size1.63140470
61MP0002419_abnormal_innate_immunity1.62613846
62MP0003303_peritoneal_inflammation1.62514934
63MP0004147_increased_porphyrin_level1.61954751
64MP0005076_abnormal_cell_differentiation1.59578281
65MP0003984_embryonic_growth_retardation1.57713230
66MP0005330_cardiomyopathy1.57405534
67MP0001845_abnormal_inflammatory_respons1.55823588
68MP0002080_prenatal_lethality1.54487360
69MP0003763_abnormal_thymus_physiology1.53829029
70MP0000490_abnormal_crypts_of1.53707339
71MP0002088_abnormal_embryonic_growth/wei1.51049345
72MP0009643_abnormal_urine_homeostasis1.50920750
73MP0003252_abnormal_bile_duct1.50194940
74MP0003221_abnormal_cardiomyocyte_apopto1.49013106
75MP0004185_abnormal_adipocyte_glucose1.48796040
76MP0004264_abnormal_extraembryonic_tissu1.47784215
77MP0002398_abnormal_bone_marrow1.47640947
78MP0000716_abnormal_immune_system1.44272107
79MP0004947_skin_inflammation1.42377970
80MP0008875_abnormal_xenobiotic_pharmacok1.41751126
81MP0001661_extended_life_span1.39848398
82MP0010630_abnormal_cardiac_muscle1.38919779
83MP0003786_premature_aging1.38685061
84MP0006036_abnormal_mitochondrial_physio1.38517673
85MP0000689_abnormal_spleen_morphology1.35949499
86MP0000313_abnormal_cell_death1.35800777
87MP0005369_muscle_phenotype1.30359235
88MP0002085_abnormal_embryonic_tissue1.29678458
89MP0003183_abnormal_peptide_metabolism1.29497643
90MP0002405_respiratory_system_inflammati1.29184172
91MP0006035_abnormal_mitochondrial_morpho1.28895476
92MP0002722_abnormal_immune_system1.26829479
93MP0003191_abnormal_cellular_cholesterol1.26545515
94MP0002084_abnormal_developmental_patter1.26272959
95MP0004197_abnormal_fetal_growth/weight/1.25379823
96MP0002136_abnormal_kidney_physiology1.25346540
97MP0008469_abnormal_protein_level1.24898159
98MP0003890_abnormal_embryonic-extraembry1.23966112
99MP0005464_abnormal_platelet_physiology1.23845629
100MP0008995_early_reproductive_senescence1.23574176
101MP0002429_abnormal_blood_cell1.23465896
102MP0009764_decreased_sensitivity_to1.20995476
103MP0009840_abnormal_foam_cell1.20310507
104MP0005332_abnormal_amino_acid1.20293038
105MP0005083_abnormal_biliary_tract1.16874957
106MP0002928_abnormal_bile_duct1.15835463
107MP0002086_abnormal_extraembryonic_tissu1.15520905
108MP0005058_abnormal_lysosome_morphology1.15112688
109MP0009333_abnormal_splenocyte_physiolog1.15001452
110MP0000609_abnormal_liver_physiology1.14767066
111MP0010352_gastrointestinal_tract_polyps1.12188302
112MP0000750_abnormal_muscle_regeneration1.10323908
113MP0004019_abnormal_vitamin_homeostasis1.09918057
114MP0002876_abnormal_thyroid_physiology1.09482728
115MP0001663_abnormal_digestive_system1.09047872
116MP0002210_abnormal_sex_determination1.08984202
117MP0001929_abnormal_gametogenesis1.08973835
118MP0000733_abnormal_muscle_development1.07061336
119MP0003453_abnormal_keratinocyte_physiol1.06770286
120MP0003567_abnormal_fetal_cardiomyocyte1.06075154
121MP0000858_altered_metastatic_potential1.05897953
122MP0004808_abnormal_hematopoietic_stem1.05458641
123MP0005220_abnormal_exocrine_pancreas1.05133385
124MP0006082_CNS_inflammation1.04862488
125MP0009703_decreased_birth_body1.04166834
126MP0003693_abnormal_embryo_hatching1.04009788
127MP0009278_abnormal_bone_marrow1.02175865
128MP0003868_abnormal_feces_composition1.00859929
129MP0000465_gastrointestinal_hemorrhage1.00103672
130MP0006292_abnormal_olfactory_placode0.99882773
131MP0010329_abnormal_lipoprotein_level0.98338985
132MP0003705_abnormal_hypodermis_morpholog0.97802884
133MP0002009_preneoplasia0.97337835
134MP0005397_hematopoietic_system_phenotyp0.97061174
135MP0001545_abnormal_hematopoietic_system0.97061174
136MP0001764_abnormal_homeostasis0.95777119
137MP0005319_abnormal_enzyme/_coenzyme0.95713389
138MP0002877_abnormal_melanocyte_morpholog0.95188448
139MP0009763_increased_sensitivity_to0.94834830
140MP0002019_abnormal_tumor_incidence0.92396292
141MP0006054_spinal_hemorrhage0.92045357
142MP0010030_abnormal_orbit_morphology0.90740832
143MP0003724_increased_susceptibility_to0.88399276
144MP0000703_abnormal_thymus_morphology0.88350039
145MP0001765_abnormal_ion_homeostasis0.86489785
146MP0000358_abnormal_cell_content/0.86026160
147MP0006138_congestive_heart_failure0.85579252
148MP0003186_abnormal_redox_activity0.85540058
149MP0005266_abnormal_metabolism0.84991836
150MP0004510_myositis0.84793683
151MP0001756_abnormal_urination0.84331028
152MP0000477_abnormal_intestine_morphology0.84184862
153MP0010307_abnormal_tumor_latency0.83525165
154MP0008877_abnormal_DNA_methylation0.83311162
155MP0005636_abnormal_mineral_homeostasis0.82952870
156MP0001533_abnormal_skeleton_physiology0.82161397
157MP0005620_abnormal_muscle_contractility0.82154727
158MP0009765_abnormal_xenobiotic_induced0.79991455
159MP0001145_abnormal_male_reproductive0.79792878
160MP0000598_abnormal_liver_morphology0.79754684
161MP0010094_abnormal_chromosome_stability0.79596495
162MP0002332_abnormal_exercise_endurance0.77566015
163MP0005381_digestive/alimentary_phenotyp0.76163999
164MP0001881_abnormal_mammary_gland0.75979690
165MP0003656_abnormal_erythrocyte_physiolo0.75872466
166MP0004215_abnormal_myocardial_fiber0.75735813
167MP0005584_abnormal_enzyme/coenzyme_acti0.75260896
168MP0001216_abnormal_epidermal_layer0.74523456
169MP0001346_abnormal_lacrimal_gland0.73056241
170MP0000678_abnormal_parathyroid_gland0.72890400
171MP0002972_abnormal_cardiac_muscle0.72808883
172MP0003699_abnormal_female_reproductive0.72664891
173MP0005666_abnormal_adipose_tissue0.72579265
174MP0005384_cellular_phenotype0.71567019
175MP0000653_abnormal_sex_gland0.71392466
176MP0005621_abnormal_cell_physiology0.71044972
177MP0001544_abnormal_cardiovascular_syste0.68727754
178MP0005385_cardiovascular_system_phenoty0.68727754
179MP0000266_abnormal_heart_morphology0.67503942
180MP0003698_abnormal_male_reproductive0.67061619
181MP0003937_abnormal_limbs/digits/tail_de0.66517780
182MP0000428_abnormal_craniofacial_morphol0.65992527
183MP0001293_anophthalmia0.65915903
184MP0003385_abnormal_body_wall0.65328214
185MP0002697_abnormal_eye_size0.64658726
186MP0002837_dystrophic_cardiac_calcinosis0.64323477
187MP0002161_abnormal_fertility/fecundity0.63713476
188MP0004130_abnormal_muscle_cell0.61433556

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)5.80720803
2Nemaline bodies (HP:0003798)5.78767777
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.62878551
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.81282502
5Exercise-induced myalgia (HP:0003738)4.76865758
6Chromsome breakage (HP:0040012)4.63983038
7Exercise-induced muscle cramps (HP:0003710)4.60271855
8Agammaglobulinemia (HP:0004432)4.28445617
9Inflammation of the large intestine (HP:0002037)3.84587319
10Colitis (HP:0002583)3.81822436
11Gastrointestinal inflammation (HP:0004386)3.65851316
12Centrally nucleated skeletal muscle fibers (HP:0003687)3.65796919
13Myopathic facies (HP:0002058)3.60718103
14Eczematoid dermatitis (HP:0000976)3.56868379
15Pustule (HP:0200039)3.54111151
16Abnormal gallbladder physiology (HP:0012438)3.48757129
17Cholecystitis (HP:0001082)3.48757129
18Recurrent bacterial skin infections (HP:0005406)3.48576076
19Recurrent viral infections (HP:0004429)3.43137405
20IgM deficiency (HP:0002850)3.41771548
21Cellulitis (HP:0100658)3.40571532
22Type 1 muscle fiber predominance (HP:0003803)3.40551443
23Recurrent fungal infections (HP:0002841)3.40056357
24Recurrent abscess formation (HP:0002722)3.34610532
25Progressive muscle weakness (HP:0003323)3.32587177
26Recurrent bronchitis (HP:0002837)3.21250498
27Thrombocytosis (HP:0001894)3.19764187
28Rimmed vacuoles (HP:0003805)3.17198476
29Gastrointestinal stroma tumor (HP:0100723)3.14515641
30B lymphocytopenia (HP:0010976)3.07999078
31Abnormality of B cell number (HP:0010975)3.07999078
32EMG: myopathic abnormalities (HP:0003458)3.01770052
33Birth length less than 3rd percentile (HP:0003561)3.00001476
34Meningitis (HP:0001287)2.99329159
35Chronic mucocutaneous candidiasis (HP:0002728)2.95967975
36Recurrent cutaneous fungal infections (HP:0011370)2.95967975
37Myoglobinuria (HP:0002913)2.95561255
38Abnormality of the left ventricular outflow tract (HP:0011103)2.93015120
39Subaortic stenosis (HP:0001682)2.93015120
40Vacuolated lymphocytes (HP:0001922)2.91043020
41Calcaneovalgus deformity (HP:0001848)2.90369045
42Rhabdomyolysis (HP:0003201)2.88270283
43Abnormal delayed hypersensitivity skin test (HP:0002963)2.87987864
44Recurrent sinusitis (HP:0011108)2.86894432
45Panhypogammaglobulinemia (HP:0003139)2.86693877
46Periodontitis (HP:0000704)2.85053492
47Recurrent skin infections (HP:0001581)2.83810419
48Interstitial pulmonary disease (HP:0006530)2.80826128
49Recurrent gram-negative bacterial infections (HP:0005420)2.79816338
50Increased connective tissue (HP:0009025)2.78786737
51Verrucae (HP:0200043)2.77801765
52Papilloma (HP:0012740)2.77801765
53Progressive external ophthalmoplegia (HP:0000590)2.77329795
54Cortical dysplasia (HP:0002539)2.75995770
55Increased nuchal translucency (HP:0010880)2.75381346
56Osteomyelitis (HP:0002754)2.72183122
57Reticulocytosis (HP:0001923)2.70115608
58Abnormality of chromosome stability (HP:0003220)2.68692055
59Abnormality of reticulocytes (HP:0004312)2.65526132
60Abnormality of the calcaneus (HP:0008364)2.65203841
61Abnormality of glutamine family amino acid metabolism (HP:0010902)2.63897622
62Abnormality of the preputium (HP:0100587)2.62235441
63Poikiloderma (HP:0001029)2.61891024
64Abnormality of T cell physiology (HP:0011840)2.59133012
65Abnormality of the fingertips (HP:0001211)2.58909768
66IgA deficiency (HP:0002720)2.56315326
67Muscle hypertrophy of the lower extremities (HP:0008968)2.56248922
68Aplasia/Hypoplasia of the uvula (HP:0010293)2.55478919
69Gout (HP:0001997)2.54157599
70Autoimmune thrombocytopenia (HP:0001973)2.49401625
71Chronic otitis media (HP:0000389)2.49047774
72Myelodysplasia (HP:0002863)2.47290075
73Lymphopenia (HP:0001888)2.45378366
74Elevated erythrocyte sedimentation rate (HP:0003565)2.45031661
75Distal arthrogryposis (HP:0005684)2.44506730
76Abnormality of cells of the lymphoid lineage (HP:0012140)2.43221967
77Deformed tarsal bones (HP:0008119)2.42464227
78Meckel diverticulum (HP:0002245)2.39114669
79Vasculitis (HP:0002633)2.35940720
80Bowel incontinence (HP:0002607)2.34518647
81Shoulder girdle muscle weakness (HP:0003547)2.33438194
82Cholelithiasis (HP:0001081)2.33359710
83Muscle stiffness (HP:0003552)2.32823906
84Reticulocytopenia (HP:0001896)2.32587458
85Myositis (HP:0100614)2.32537572
86Duodenal stenosis (HP:0100867)2.31763671
87Small intestinal stenosis (HP:0012848)2.31763671
88Abnormality of the ileum (HP:0001549)2.28700962
89Nasal polyposis (HP:0100582)2.27744412
90Recurrent pneumonia (HP:0006532)2.27177109
91Nephroblastoma (Wilms tumor) (HP:0002667)2.26684071
92Ragged-red muscle fibers (HP:0003200)2.26634403
93Abnormality of purine metabolism (HP:0004352)2.26577982
94Abnormal large intestine physiology (HP:0012700)2.26171518
95Microvesicular hepatic steatosis (HP:0001414)2.25176114
96Cafe-au-lait spot (HP:0000957)2.24920413
97Truncus arteriosus (HP:0001660)2.23352925
98Long clavicles (HP:0000890)2.22856171
99Calf muscle hypertrophy (HP:0008981)2.21987559
100Abnormality of skeletal muscle fiber size (HP:0012084)2.21760335
101Abnormality of monocarboxylic acid metabolism (HP:0010996)2.21737238
102Mediastinal lymphadenopathy (HP:0100721)2.19865829
103Neck muscle weakness (HP:0000467)2.18406961
104Cheilitis (HP:0100825)2.18171302
105Difficulty running (HP:0009046)2.17938267
106Gingivitis (HP:0000230)2.17147661
107Pelvic girdle muscle weakness (HP:0003749)2.16699573
108Abnormality of nucleobase metabolism (HP:0010932)2.16123147
109Abnormality of T cells (HP:0002843)2.16040548
110Muscle fiber splitting (HP:0003555)2.16019566
111Thyroiditis (HP:0100646)2.14896171
112Abnormality of the gastric mucosa (HP:0004295)2.12402934
113Dysmetric saccades (HP:0000641)2.10843947
114Hypoplasia of the thymus (HP:0000778)2.10729001
115Abnormality of chloride homeostasis (HP:0011422)2.09688575
116Abnormal lung lobation (HP:0002101)2.09665880
117Chronic diarrhea (HP:0002028)2.09128097
118Dehydration (HP:0001944)2.08588729
119Distal lower limb amyotrophy (HP:0008944)2.08554601
120Abnormality of cochlea (HP:0000375)2.08248725
121Embryonal renal neoplasm (HP:0011794)2.06815290
122Recurrent lower respiratory tract infections (HP:0002783)2.06329192
123Hyporeflexia of lower limbs (HP:0002600)2.06247447
124Multiple enchondromatosis (HP:0005701)2.04863789
125Abnormality of aromatic amino acid family metabolism (HP:0004338)2.04726243
126Encephalitis (HP:0002383)2.04456915
127Urticaria (HP:0001025)2.03092190
128IgG deficiency (HP:0004315)2.02842614
129Emphysema (HP:0002097)2.01533225
130Skin ulcer (HP:0200042)2.01348183
131Abnormal gallbladder morphology (HP:0012437)2.01296469
132Sepsis (HP:0100806)2.00853376
133Impaired platelet aggregation (HP:0003540)1.99940140
134Abnormal platelet function (HP:0011869)1.99940140
135Abnormality of the calf musculature (HP:0001430)1.99161315
136Abnormality of proline metabolism (HP:0010907)1.98861807
137Hydroxyprolinuria (HP:0003080)1.98861807
138Gingival bleeding (HP:0000225)1.98665204
139Overlapping toe (HP:0001845)1.98580218
140Abnormality of glycolysis (HP:0004366)1.98426676
141Ectopic kidney (HP:0000086)1.98392941
142Spontaneous hematomas (HP:0007420)1.96941488
143Hyperglycinuria (HP:0003108)1.96176590
144Abnormality of pyrimidine metabolism (HP:0004353)1.95213475
145Hyperuricemia (HP:0002149)1.94709371
146Increased purine levels (HP:0004368)1.94709371
147Sudden death (HP:0001699)1.94643548
148EMG: neuropathic changes (HP:0003445)1.91508616
149Ankyloglossia (HP:0010296)1.90915604
150Villous atrophy (HP:0011473)1.90606373
151Abnormality of small intestinal villus morphology (HP:0011472)1.90606373
152Abnormality of macrophages (HP:0004311)1.89581012
153Eosinophilia (HP:0001880)1.89443431
154Restrictive lung disease (HP:0002091)1.88568685
155Viral hepatitis (HP:0006562)1.88158242
156Bronchitis (HP:0012387)1.87869223
157Systemic lupus erythematosus (HP:0002725)1.87329567
158Micronodular cirrhosis (HP:0001413)1.87235767
159Acute myeloid leukemia (HP:0004808)1.86407570
160Abnormality of T cell number (HP:0011839)1.85478553
161Ependymoma (HP:0002888)1.84359869
162Abnormality of the duodenum (HP:0002246)1.83850326
163Ulnar deviation of the wrist (HP:0003049)1.83576778
164Abnormality of the musculature of the pelvis (HP:0001469)1.83571359
165Abnormality of the hip-girdle musculature (HP:0001445)1.83571359
166Abnormality of the nasal mucosa (HP:0000433)1.82351133
167Duplicated collecting system (HP:0000081)1.81702929
168Volvulus (HP:0002580)1.81471015
169Abnormality of the carotid arteries (HP:0005344)1.81430991
170Intrahepatic cholestasis (HP:0001406)1.80508751
171Neutropenia (HP:0001875)1.80367265
172Fat malabsorption (HP:0002630)1.80338464
173Premature loss of primary teeth (HP:0006323)1.79957747
174Urinary glycosaminoglycan excretion (HP:0003541)1.79575755
175Mucopolysacchariduria (HP:0008155)1.79575755
176Esophageal varix (HP:0002040)1.78589462
177T lymphocytopenia (HP:0005403)1.78539556
178Joint hemorrhage (HP:0005261)1.77302353
179Abnormal foot bone ossification (HP:0010675)1.77207920
180Keratoconjunctivitis (HP:0001096)1.77184282
181Increased serum pyruvate (HP:0003542)1.73759855
182Aplasia/Hypoplasia of the earlobes (HP:0009906)1.72649803
183Abnormality of homocysteine metabolism (HP:0010919)1.72441076
184Homocystinuria (HP:0002156)1.72441076
185Increased variability in muscle fiber diameter (HP:0003557)1.69052541
186Areflexia of lower limbs (HP:0002522)1.65938635
187Sandal gap (HP:0001852)1.65161198
188Abnormality of the salivary glands (HP:0010286)1.65104556
189Abnormality of DNA repair (HP:0003254)1.64226641
190Rhabdomyosarcoma (HP:0002859)1.64150372
191Sloping forehead (HP:0000340)1.63454880
192High anterior hairline (HP:0009890)1.63115566
193Distal lower limb muscle weakness (HP:0009053)1.62887065
194Abnormality of the tricuspid valve (HP:0001702)1.62702056
195Facial hemangioma (HP:0000329)1.62609413
196Absent radius (HP:0003974)1.61900758
197Narrow face (HP:0000275)1.61830871
198Dilated cardiomyopathy (HP:0001644)1.61544756
199Abnormality of chromosome segregation (HP:0002916)1.60901682

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.20171489
2BUB14.01282627
3CDC73.99955797
4OBSCN3.81353238
5TTK3.80638854
6MAP4K13.48053643
7EPHA22.82189597
8TTN2.71000982
9TAOK32.65123412
10MAP3K142.61184452
11MAP3K102.42749033
12CCNB12.41160847
13MST42.39761776
14PLK42.39105060
15NEK12.37891315
16SRPK12.36341999
17WEE12.21235839
18PBK2.20027945
19IRAK32.13654857
20IRAK42.07245818
21TYK21.98851857
22STK101.96620318
23FRK1.92339596
24BTK1.89510571
25TBK11.88025964
26ICK1.87954627
27KSR21.82002228
28GRK61.79871459
29BCKDK1.71658628
30BLK1.69947204
31CSF1R1.66507697
32TSSK61.65552478
33TEC1.62823618
34EIF2AK31.61372112
35BRSK21.59996405
36CHEK21.59574899
37CDK121.58456133
38PLK11.57247394
39EEF2K1.53945950
40LRRK21.48338851
41JAK31.44924849
42IKBKE1.44791671
43NME11.43213381
44PHKG21.41908662
45PHKG11.41908662
46CHEK11.41247210
47FGFR41.40436761
48FLT31.40194230
49KIT1.40060289
50ZAP701.39555730
51PTK61.38966382
52PRPF4B1.35477082
53RPS6KB21.34422590
54BRSK11.31982708
55RAF11.30875542
56SYK1.29464486
57JAK11.28352701
58PKN21.27704173
59EPHB11.22409472
60CDK71.20430036
61PLK31.19788157
62BRAF1.18638789
63NEK91.18635605
64CHUK1.18167727
65STK391.16087078
66SMG11.15494679
67TGFBR21.14357400
68IKBKB1.13121993
69PIM11.11658385
70DYRK1B1.10658647
71RPS6KA41.08925721
72MAP2K31.06306406
73AURKA1.05922110
74NUAK11.03743912
75ITK1.03030289
76TRIB31.00465923
77MAP2K21.00069581
78CSK0.99520900
79EIF2AK10.99507718
80MKNK10.98663408
81ATM0.97689188
82CDK10.96945495
83CDK20.96197988
84NLK0.93610742
85KSR10.92370999
86CDK40.90588387
87TLK10.89021387
88NEK20.88383263
89OXSR10.88124293
90LATS20.86496335
91MTOR0.84193541
92STK40.83994959
93CDK60.80887372
94CDK90.80143463
95MKNK20.79710167
96MAP3K30.79510715
97LYN0.78232454
98JAK20.74405674
99CDK80.71900831
100ZAK0.71884955
101SIK10.71384430
102MAP3K130.71308345
103MAPK110.71227007
104LMTK20.69906244
105WNK40.68448827
106CLK10.68260885
107LCK0.67770451
108PIM20.66193324
109PASK0.65900706
110PIK3CG0.64948188
111AKT20.64607840
112STK160.62855939
113MAP3K80.60523575
114PDK20.60179978
115TRPM70.59806795
116MAP3K90.57729014
117HCK0.55309518
118PAK40.54624972
119MST1R0.54417301
120MAPKAPK30.54029845
121BMX0.53260067
122MAP3K70.53133674
123MATK0.52745242
124RIPK40.52514346
125PNCK0.51282626
126MAP2K60.50268561
127PRKCI0.50087003
128MELK0.49904390
129BRD40.49726125
130DMPK0.49343177
131STK30.48775025
132NME20.47857260
133AURKB0.47838567
134FGFR30.47583052
135DYRK30.47339370
136ALK0.47083804
137EIF2AK20.46658792
138RIPK10.46143076
139PRKDC0.45440513
140SCYL20.45307107
141PRKAA10.44758450
142CAMK1G0.43659850
143GSK3B0.43477369
144CSNK2A20.43384944
145PAK10.42802326
146PRKCQ0.42646528
147MAPK140.42404594
148CSNK1E0.42365889
149MYLK0.42134224
150TESK20.41440505
151MARK30.40740356
152LATS10.40503248
153RPS6KA10.40499340
154ABL10.38254095
155ARAF0.38126891
156MAPK100.37508338
157HIPK20.37264362
158MAPK120.37198975
159VRK10.36318252
160CAMK1D0.36219605
161CDK11A0.36069935
162TAOK20.35580456
163CDK150.34696792
164MAPK40.32843458
165TXK0.32453756
166PRKAA20.31973051
167CDK180.31518751
168ATR0.31161682
169RPS6KB10.28431336

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041103.13846084
2Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.00536729
3Primary immunodeficiency_Homo sapiens_hsa053402.99777621
4RNA transport_Homo sapiens_hsa030132.52947728
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.49330674
6Spliceosome_Homo sapiens_hsa030402.45259986
7Nucleotide excision repair_Homo sapiens_hsa034202.44056666
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.41407641
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.34770143
10Fanconi anemia pathway_Homo sapiens_hsa034602.34491763
11B cell receptor signaling pathway_Homo sapiens_hsa046622.20994613
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.15816486
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.12543789
14NF-kappa B signaling pathway_Homo sapiens_hsa040642.07424967
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.00487092
16mRNA surveillance pathway_Homo sapiens_hsa030151.92053866
17Pentose and glucuronate interconversions_Homo sapiens_hsa000401.91650490
18Antigen processing and presentation_Homo sapiens_hsa046121.86197568
19Caffeine metabolism_Homo sapiens_hsa002321.77135847
20Leishmaniasis_Homo sapiens_hsa051401.76396374
21Pentose phosphate pathway_Homo sapiens_hsa000301.68546852
22Other glycan degradation_Homo sapiens_hsa005111.65133101
23Hematopoietic cell lineage_Homo sapiens_hsa046401.62938929
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.57605431
25Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.52741188
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.50549160
27Oocyte meiosis_Homo sapiens_hsa041141.47704161
28Osteoclast differentiation_Homo sapiens_hsa043801.43254598
29Tryptophan metabolism_Homo sapiens_hsa003801.41163786
30Selenocompound metabolism_Homo sapiens_hsa004501.40749764
31Basal transcription factors_Homo sapiens_hsa030221.34636629
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.33484912
33Staphylococcus aureus infection_Homo sapiens_hsa051501.31923513
34Vitamin digestion and absorption_Homo sapiens_hsa049771.30753513
35Pyrimidine metabolism_Homo sapiens_hsa002401.28655172
36Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.26920484
37RNA degradation_Homo sapiens_hsa030181.25101810
38NOD-like receptor signaling pathway_Homo sapiens_hsa046211.24433004
39Measles_Homo sapiens_hsa051621.23860677
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.23648744
41Influenza A_Homo sapiens_hsa051641.23088169
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.21321727
43Fatty acid degradation_Homo sapiens_hsa000711.20918438
44Primary bile acid biosynthesis_Homo sapiens_hsa001201.20590296
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.20402305
46Arginine biosynthesis_Homo sapiens_hsa002201.19655294
47Herpes simplex infection_Homo sapiens_hsa051681.16365056
48Folate biosynthesis_Homo sapiens_hsa007901.15854526
49Thyroid cancer_Homo sapiens_hsa052161.14291184
50Toll-like receptor signaling pathway_Homo sapiens_hsa046201.14131977
51Legionellosis_Homo sapiens_hsa051341.13283225
52DNA replication_Homo sapiens_hsa030301.13170400
53Toxoplasmosis_Homo sapiens_hsa051451.12418324
54Non-homologous end-joining_Homo sapiens_hsa034501.10999648
55Fat digestion and absorption_Homo sapiens_hsa049751.09960299
56RNA polymerase_Homo sapiens_hsa030201.07763378
57Lysine degradation_Homo sapiens_hsa003101.07493228
58Starch and sucrose metabolism_Homo sapiens_hsa005001.07237973
59Asthma_Homo sapiens_hsa053101.06821860
60Leukocyte transendothelial migration_Homo sapiens_hsa046701.06685145
61Small cell lung cancer_Homo sapiens_hsa052221.04105013
62Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.03872837
63Pertussis_Homo sapiens_hsa051331.03447119
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.02670865
65Complement and coagulation cascades_Homo sapiens_hsa046101.01787981
66Glutathione metabolism_Homo sapiens_hsa004801.01618990
67Central carbon metabolism in cancer_Homo sapiens_hsa052300.99193339
68Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.98443590
69ABC transporters_Homo sapiens_hsa020100.98225532
70Base excision repair_Homo sapiens_hsa034100.97888719
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.97765750
72Apoptosis_Homo sapiens_hsa042100.96585944
73Peroxisome_Homo sapiens_hsa041460.96315037
74Insulin signaling pathway_Homo sapiens_hsa049100.96308848
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.95138643
76Non-small cell lung cancer_Homo sapiens_hsa052230.93968049
77Purine metabolism_Homo sapiens_hsa002300.93735834
78Hepatitis C_Homo sapiens_hsa051600.93197359
79Histidine metabolism_Homo sapiens_hsa003400.92586362
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.91013675
81One carbon pool by folate_Homo sapiens_hsa006700.89170323
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.88452438
83Renin-angiotensin system_Homo sapiens_hsa046140.88091459
84Tuberculosis_Homo sapiens_hsa051520.84257058
85Glycosaminoglycan degradation_Homo sapiens_hsa005310.83707790
86Sulfur metabolism_Homo sapiens_hsa009200.81750629
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81355196
88MicroRNAs in cancer_Homo sapiens_hsa052060.80372332
89p53 signaling pathway_Homo sapiens_hsa041150.80159880
90TNF signaling pathway_Homo sapiens_hsa046680.77692298
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76192681
92Propanoate metabolism_Homo sapiens_hsa006400.75641802
93Proteasome_Homo sapiens_hsa030500.75158769
94Mismatch repair_Homo sapiens_hsa034300.74526170
95Glycerolipid metabolism_Homo sapiens_hsa005610.72174449
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71817493
97Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.71618058
98Chemical carcinogenesis_Homo sapiens_hsa052040.71471171
99Ribosome_Homo sapiens_hsa030100.71308546
100Hepatitis B_Homo sapiens_hsa051610.70749434
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70562235
102Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70283295
103PPAR signaling pathway_Homo sapiens_hsa033200.70128074
104Colorectal cancer_Homo sapiens_hsa052100.69661307
105Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69431392
106Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69326711
107Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68946543
108Pyruvate metabolism_Homo sapiens_hsa006200.67708264
109N-Glycan biosynthesis_Homo sapiens_hsa005100.67671888
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67582430
111Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.67064774
112Fructose and mannose metabolism_Homo sapiens_hsa000510.66297810
113Cardiac muscle contraction_Homo sapiens_hsa042600.65855805
114Nitrogen metabolism_Homo sapiens_hsa009100.65694415
115Carbon metabolism_Homo sapiens_hsa012000.65442491
116Adherens junction_Homo sapiens_hsa045200.64567513
117Homologous recombination_Homo sapiens_hsa034400.64446775
118Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63445571
119Pancreatic cancer_Homo sapiens_hsa052120.63263889
120Dilated cardiomyopathy_Homo sapiens_hsa054140.62981246
121mTOR signaling pathway_Homo sapiens_hsa041500.62108413
122Protein export_Homo sapiens_hsa030600.61328695
123Endometrial cancer_Homo sapiens_hsa052130.61294612
124Retinol metabolism_Homo sapiens_hsa008300.61214839
125beta-Alanine metabolism_Homo sapiens_hsa004100.60078375
126AMPK signaling pathway_Homo sapiens_hsa041520.59460594
127Chronic myeloid leukemia_Homo sapiens_hsa052200.58860035
128Arginine and proline metabolism_Homo sapiens_hsa003300.58314517
129Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58309927
130Circadian rhythm_Homo sapiens_hsa047100.57909758
131Protein digestion and absorption_Homo sapiens_hsa049740.57772352
132Acute myeloid leukemia_Homo sapiens_hsa052210.57689905
133Biosynthesis of amino acids_Homo sapiens_hsa012300.56452287
134Alcoholism_Homo sapiens_hsa050340.56191219
135Allograft rejection_Homo sapiens_hsa053300.55815571
136Shigellosis_Homo sapiens_hsa051310.55778778
137Viral carcinogenesis_Homo sapiens_hsa052030.54592021
138Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54454206
139Sulfur relay system_Homo sapiens_hsa041220.54282137
140Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54230168
141Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53369814
142Bladder cancer_Homo sapiens_hsa052190.52593706
143Glioma_Homo sapiens_hsa052140.49770397
144Glucagon signaling pathway_Homo sapiens_hsa049220.49764406
145Inositol phosphate metabolism_Homo sapiens_hsa005620.49536907
146ErbB signaling pathway_Homo sapiens_hsa040120.48620338
147Renal cell carcinoma_Homo sapiens_hsa052110.48235748
148Epstein-Barr virus infection_Homo sapiens_hsa051690.47548774
149Prostate cancer_Homo sapiens_hsa052150.46695272
150HIF-1 signaling pathway_Homo sapiens_hsa040660.46681577
151Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45276344
152HTLV-I infection_Homo sapiens_hsa051660.45217676
153Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43535421
154Steroid biosynthesis_Homo sapiens_hsa001000.42505300
155Fatty acid elongation_Homo sapiens_hsa000620.41910219
156Huntingtons disease_Homo sapiens_hsa050160.39871981
157Fatty acid metabolism_Homo sapiens_hsa012120.39656276
158Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35128451
159Parkinsons disease_Homo sapiens_hsa050120.32565947
160Galactose metabolism_Homo sapiens_hsa000520.32071059
161FoxO signaling pathway_Homo sapiens_hsa040680.32047484
162Systemic lupus erythematosus_Homo sapiens_hsa053220.31487565
163VEGF signaling pathway_Homo sapiens_hsa043700.30811348
164Wnt signaling pathway_Homo sapiens_hsa043100.25860599
165Phosphatidylinositol signaling system_Homo sapiens_hsa040700.25301726
166Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.24098731
167Insulin resistance_Homo sapiens_hsa049310.23596260
168Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.19426769

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