CEP85L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene was identified as a breast cancer antigen. Nothing more is known of its function at this time. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)9.13003414
2fusion of sperm to egg plasma membrane (GO:0007342)8.44324321
3cell wall macromolecule metabolic process (GO:0044036)8.23160217
4cell wall macromolecule catabolic process (GO:0016998)8.23160217
5acrosome reaction (GO:0007340)7.65556407
6activated T cell proliferation (GO:0050798)7.32462508
7multicellular organism reproduction (GO:0032504)7.21744381
8sperm-egg recognition (GO:0035036)6.98964845
9acrosome assembly (GO:0001675)6.91146448
10plasma membrane fusion (GO:0045026)6.36337864
11cell-cell recognition (GO:0009988)6.32559971
12reproduction (GO:0000003)6.30691185
13binding of sperm to zona pellucida (GO:0007339)6.26532768
14cilium or flagellum-dependent cell motility (GO:0001539)6.06757538
15epithelial cilium movement (GO:0003351)5.81966464
16spermatid development (GO:0007286)5.78894478
17motile cilium assembly (GO:0044458)5.41586670
18axonemal dynein complex assembly (GO:0070286)5.35734974
19regulation of protein glycosylation (GO:0060049)5.35085710
20monoubiquitinated protein deubiquitination (GO:0035520)5.20124020
21negative regulation of inclusion body assembly (GO:0090084)4.68623532
22positive regulation of gamma-delta T cell activation (GO:0046645)4.68209244
23single fertilization (GO:0007338)4.60279290
24male meiosis (GO:0007140)4.52170559
25piRNA metabolic process (GO:0034587)4.51933321
26epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.51472318
27negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.47729860
28negative regulation of cell killing (GO:0031342)4.47729860
29cilium movement (GO:0003341)4.46197745
30organic cation transport (GO:0015695)4.37409365
31regulation of B cell receptor signaling pathway (GO:0050855)4.10277248
32spermatogenesis (GO:0007283)4.05255070
33male gamete generation (GO:0048232)4.04619162
34regulation of cilium movement (GO:0003352)3.96053632
35synaptonemal complex organization (GO:0070193)3.95618718
36synaptonemal complex assembly (GO:0007130)3.93249652
37positive regulation of glycoprotein biosynthetic process (GO:0010560)3.90936092
38sperm capacitation (GO:0048240)3.88400085
39phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.87954413
40antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.81498106
41fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.81479536
42establishment of protein localization to Golgi (GO:0072600)3.80238868
43fertilization (GO:0009566)3.79419735
44gamete generation (GO:0007276)3.78228101
45negative T cell selection (GO:0043383)3.73448543
46positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.72585508
47regulation of inclusion body assembly (GO:0090083)3.69557192
48protein targeting to Golgi (GO:0000042)3.67729663
49microtubule depolymerization (GO:0007019)3.62815702
50carnitine transmembrane transport (GO:1902603)3.62155191
51urea metabolic process (GO:0019627)3.59593975
52urea cycle (GO:0000050)3.59593975
53alpha-linolenic acid metabolic process (GO:0036109)3.57787793
54amino-acid betaine transport (GO:0015838)3.55517029
55carnitine transport (GO:0015879)3.55517029
56positive T cell selection (GO:0043368)3.54219651
57retrograde transport, vesicle recycling within Golgi (GO:0000301)3.53451456
58protein carboxylation (GO:0018214)3.51148836
59peptidyl-glutamic acid carboxylation (GO:0017187)3.51148836
60response to interleukin-15 (GO:0070672)3.50768641
61peptidyl-glutamic acid modification (GO:0018200)3.46784149
62negative thymic T cell selection (GO:0045060)3.46671260
63regulation of gamma-delta T cell differentiation (GO:0045586)3.43384204
64histone H3-K36 demethylation (GO:0070544)3.43336653
65protein K11-linked deubiquitination (GO:0035871)3.41899250
66spermatid nucleus differentiation (GO:0007289)3.40663051
67heterotypic cell-cell adhesion (GO:0034113)3.40361551
68positive regulation of granulocyte differentiation (GO:0030854)3.36782025
69positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.35961849
70regulation of gamma-delta T cell activation (GO:0046643)3.35725788
71cellular response to interleukin-15 (GO:0071350)3.32935716
72glycerol ether metabolic process (GO:0006662)3.32662328
73triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.32012789
74cellular extravasation (GO:0045123)3.31099059
75negative regulation of T cell mediated immunity (GO:0002710)3.30081625
76regulation of protein activation cascade (GO:2000257)3.28548062
77interferon-gamma production (GO:0032609)3.23679432
78cellular process involved in reproduction in multicellular organism (GO:0022412)3.18505521
79complement activation, alternative pathway (GO:0006957)3.17370735
80nitrogen cycle metabolic process (GO:0071941)3.17206703
81male meiosis I (GO:0007141)3.16619008
82quaternary ammonium group transport (GO:0015697)3.15545498
83T cell migration (GO:0072678)3.14909976
84ventricular system development (GO:0021591)3.13842126
85B cell receptor signaling pathway (GO:0050853)3.13835790
86germ cell development (GO:0007281)3.12069146
87sexual reproduction (GO:0019953)3.12005001
88histone H3-K9 demethylation (GO:0033169)3.11079815
89regulation of complement activation (GO:0030449)3.11024925
90macroautophagy (GO:0016236)3.10476030
91fatty acid transmembrane transport (GO:1902001)3.07654369
92T cell selection (GO:0045058)3.07240299
93antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.06738518
94positive regulation of glycolytic process (GO:0045821)3.06217908
95low-density lipoprotein particle remodeling (GO:0034374)3.04313299
96ether metabolic process (GO:0018904)3.04067900
97negative regulation of lymphocyte mediated immunity (GO:0002707)3.03752457
98regulation of regulatory T cell differentiation (GO:0045589)3.01288725
99seminiferous tubule development (GO:0072520)3.01171838
100regulation of fibroblast apoptotic process (GO:2000269)3.00303261
101regulation of meiosis I (GO:0060631)2.98442581
102positive regulation of glycoprotein metabolic process (GO:1903020)2.95389185
103amino-acid betaine metabolic process (GO:0006577)2.94070540
104leukocyte aggregation (GO:0070486)2.93030296
105multicellular organismal reproductive process (GO:0048609)2.91851652
106carnitine shuttle (GO:0006853)2.91470508
107tryptophan catabolic process (GO:0006569)2.89057626
108indole-containing compound catabolic process (GO:0042436)2.89057626
109indolalkylamine catabolic process (GO:0046218)2.89057626
110cell recognition (GO:0008037)2.88464986
111tolerance induction (GO:0002507)2.83090797
112antigen processing and presentation of endogenous antigen (GO:0019883)2.82428289
113interkinetic nuclear migration (GO:0022027)2.82311821
114calcium ion-dependent exocytosis (GO:0017156)2.81721619
115negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.81710738
116protein K48-linked deubiquitination (GO:0071108)2.79826418
117neural tube formation (GO:0001841)2.78899037
118regulation of triglyceride catabolic process (GO:0010896)2.78649874
119tryptophan metabolic process (GO:0006568)2.77967386
120T cell homeostasis (GO:0043029)2.77869645
121positive regulation of fatty acid beta-oxidation (GO:0032000)2.77664993
122response to pheromone (GO:0019236)2.76281837
123antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.74529567
124nuclear pore complex assembly (GO:0051292)2.74397433
125histone H3-K4 trimethylation (GO:0080182)2.73379145
126cerebellar Purkinje cell differentiation (GO:0021702)2.72182241
127kynurenine metabolic process (GO:0070189)2.71300964
128RNA localization (GO:0006403)2.68506695
129histone H4-K16 acetylation (GO:0043984)2.68357593
130nucleus localization (GO:0051647)2.67036718
131aromatic amino acid family catabolic process (GO:0009074)2.66205093
132negative regulation of B cell proliferation (GO:0030889)2.64183472
133protein K63-linked deubiquitination (GO:0070536)2.64037600
134protein-lipid complex remodeling (GO:0034368)2.62877581
135macromolecular complex remodeling (GO:0034367)2.62877581
136plasma lipoprotein particle remodeling (GO:0034369)2.62877581
137carnitine metabolic process (GO:0009437)2.62442984
138plasma lipoprotein particle clearance (GO:0034381)2.62366617
139histone mRNA catabolic process (GO:0071044)2.62101362
140alpha-beta T cell differentiation (GO:0046632)2.62059090
141negative regulation of B cell mediated immunity (GO:0002713)2.60755553
142negative regulation of immunoglobulin mediated immune response (GO:0002890)2.60755553
143positive regulation of cellular amide metabolic process (GO:0034250)2.58934977
144positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.58534945
145positive regulation of lipid catabolic process (GO:0050996)2.58270871
146mitotic sister chromatid cohesion (GO:0007064)2.56434722
147regulation of fatty acid beta-oxidation (GO:0031998)2.56213630
148regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.55610277
149regulation of glycoprotein biosynthetic process (GO:0010559)2.55541008
150chromosome condensation (GO:0030261)2.55390744
151chromosome organization involved in meiosis (GO:0070192)2.55143066
152high-density lipoprotein particle remodeling (GO:0034375)2.53245535
153positive regulation of mRNA 3-end processing (GO:0031442)2.52751473
154fat-soluble vitamin biosynthetic process (GO:0042362)2.52047785
155negative regulation of adaptive immune response (GO:0002820)2.51934720
156regulation of alpha-beta T cell proliferation (GO:0046640)2.50635102
157phospholipid homeostasis (GO:0055091)2.49983998
158modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.49921919
159modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.49921919
160positive regulation by organism of defense response of other organism involved in symbiotic interact2.49921919
161modulation by symbiont of host immune response (GO:0052553)2.49921919
162positive regulation by symbiont of host defense response (GO:0052509)2.49921919
163modulation by symbiont of host defense response (GO:0052031)2.49921919
164DNA packaging (GO:0006323)2.49591873
165negative regulation of fibrinolysis (GO:0051918)2.48673553
166regulation of fibrinolysis (GO:0051917)2.48440036
167peptidyl-lysine trimethylation (GO:0018023)2.47765116
168bile acid biosynthetic process (GO:0006699)2.47654390
169DNA methylation involved in gamete generation (GO:0043046)2.47480893
170embryonic process involved in female pregnancy (GO:0060136)2.47268593
171reverse cholesterol transport (GO:0043691)2.46476353
172protein K48-linked ubiquitination (GO:0070936)2.46060732
173neutrophil activation involved in immune response (GO:0002283)2.45410309
174leukocyte cell-cell adhesion (GO:0007159)2.44533086
175microtubule nucleation (GO:0007020)2.43309957
176centrosome localization (GO:0051642)2.43201753
177regulation of isotype switching to IgG isotypes (GO:0048302)2.39937359
178histone lysine demethylation (GO:0070076)2.39603709
179regulation of T cell tolerance induction (GO:0002664)2.39001975
180protein localization to Golgi apparatus (GO:0034067)2.38997253
181regulation of interleukin-12 biosynthetic process (GO:0045075)2.38634267
182negative regulation of leukocyte mediated immunity (GO:0002704)2.38583980
183tyrosine phosphorylation of STAT protein (GO:0007260)2.37726239
184antigen receptor-mediated signaling pathway (GO:0050851)2.36766952
185T cell receptor signaling pathway (GO:0050852)2.35882920
186alpha-beta T cell activation (GO:0046631)2.35379144
187establishment of nucleus localization (GO:0040023)2.34925951
188positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.34257267
189negative regulation of NF-kappaB import into nucleus (GO:0042347)2.34141706
190CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.33963866
191regulation of NFAT protein import into nucleus (GO:0051532)2.33527332
192regulation of mRNA 3-end processing (GO:0031440)2.33466984
193myeloid leukocyte mediated immunity (GO:0002444)2.33391664
194regulation of B cell differentiation (GO:0045577)2.32713901

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.76776578
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.43150338
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.97105424
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.41557763
5GBX2_23144817_ChIP-Seq_PC3_Human2.76648592
6EGR1_23403033_ChIP-Seq_LIVER_Mouse2.66116467
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.63259559
8RUNX_20019798_ChIP-Seq_JUKART_Human2.62994844
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.60442985
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.42839806
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.40916719
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.33725391
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.33365157
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.30397013
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.27517000
16IGF1R_20145208_ChIP-Seq_DFB_Human2.23971539
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.15271901
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.07166191
19FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.00668912
20PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.99125753
21PPARA_22158963_ChIP-Seq_LIVER_Mouse1.95024744
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.92941615
23IRF8_22096565_ChIP-ChIP_GC-B_Human1.89633628
24PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.81976122
25EZH2_22144423_ChIP-Seq_EOC_Human1.77642651
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.71623272
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.68119014
28Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.61394583
29FUS_26573619_Chip-Seq_HEK293_Human1.60666629
30FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.58813804
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.54946843
32UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54516451
33ER_23166858_ChIP-Seq_MCF-7_Human1.53567805
34OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53281354
35STAT3_23295773_ChIP-Seq_U87_Human1.50013165
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48874089
37MYB_26560356_Chip-Seq_TH2_Human1.48610976
38CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.48175245
39SMAD4_21799915_ChIP-Seq_A2780_Human1.48072386
40KDM2B_26808549_Chip-Seq_REH_Human1.48039955
41P300_19829295_ChIP-Seq_ESCs_Human1.47880406
42TP53_16413492_ChIP-PET_HCT116_Human1.43850942
43PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41613190
44NFE2_27457419_Chip-Seq_LIVER_Mouse1.40945182
45MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.40152471
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39652411
47CBP_20019798_ChIP-Seq_JUKART_Human1.39197062
48IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39197062
49NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.38661583
50VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.36862612
51TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.36734671
52TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.36702674
53VDR_22108803_ChIP-Seq_LS180_Human1.36322865
54EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.36311583
55KAP1_22055183_ChIP-Seq_ESCs_Mouse1.35910862
56PRDM14_20953172_ChIP-Seq_ESCs_Human1.33307688
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33263633
58ZNF274_21170338_ChIP-Seq_K562_Hela1.32589329
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31576307
60STAT1_17558387_ChIP-Seq_HELA_Human1.31077418
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30761502
62GATA3_27048872_Chip-Seq_THYMUS_Human1.30692973
63ELK4_26923725_Chip-Seq_MESODERM_Mouse1.30609417
64CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.30373851
65BCAT_22108803_ChIP-Seq_LS180_Human1.30343864
66KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.29461062
67TAF15_26573619_Chip-Seq_HEK293_Human1.28795350
68SCL_19346495_ChIP-Seq_HPC-7_Human1.28772045
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28598743
70EWS_26573619_Chip-Seq_HEK293_Human1.25580573
71RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.25356968
72SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24417317
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.24261476
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.23517308
75IRF8_27001747_Chip-Seq_BMDM_Mouse1.21627708
76ZFP57_27257070_Chip-Seq_ESCs_Mouse1.19192763
77GATA3_26560356_Chip-Seq_TH2_Human1.19126602
78PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.18780043
79GATA1_22025678_ChIP-Seq_K562_Human1.18308296
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.17810890
81OCT4_21477851_ChIP-Seq_ESCs_Mouse1.16923654
82VDR_24787735_ChIP-Seq_THP-1_Human1.16581017
83PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16484748
84TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14646462
85IRF8_21731497_ChIP-ChIP_J774_Mouse1.14421685
86MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.14144679
87CBX2_27304074_Chip-Seq_ESCs_Mouse1.14103965
88CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.14019688
89TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12769778
90TCF4_18268006_ChIP-ChIP_LS174T_Human1.12525490
91AR_25329375_ChIP-Seq_VCAP_Human1.12004678
92PIAS1_25552417_ChIP-Seq_VCAP_Human1.11623328
93CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11313871
94PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10629674
95OCT4_18555785_Chip-Seq_ESCs_Mouse1.10067142
96EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09660532
97POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09340125
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09340125
99WDR5_24793694_ChIP-Seq_LNCAP_Human1.09105349
100RUNX2_22187159_ChIP-Seq_PCA_Human1.08971539
101SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.08886660
102CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08734897
103TAL1_26923725_Chip-Seq_HPCs_Mouse1.08539622
104EP300_21415370_ChIP-Seq_HL-1_Mouse1.07757278
105CRX_20693478_ChIP-Seq_RETINA_Mouse1.07266493
106FLI1_21867929_ChIP-Seq_TH2_Mouse1.05501313
107CMYC_18555785_Chip-Seq_ESCs_Mouse1.05035496
108TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04721090
109BP1_19119308_ChIP-ChIP_Hs578T_Human1.04135987
110MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03501997
111MYB_26560356_Chip-Seq_TH1_Human1.03469052
112GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.01751462
113SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01038776
114GATA3_26560356_Chip-Seq_TH1_Human1.00938700
115RBPJ_22232070_ChIP-Seq_NCS_Mouse1.00814242
116P53_22387025_ChIP-Seq_ESCs_Mouse1.00475814
117GATA1_26923725_Chip-Seq_HPCs_Mouse1.00404742
118NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99659975
119FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99289338
120RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97829227
121ESRRB_18555785_Chip-Seq_ESCs_Mouse0.97791642
122STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.97769892
123NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97677557
124STAT3_18555785_Chip-Seq_ESCs_Mouse0.97415887
125TBL1_22424771_ChIP-Seq_293T_Human0.97407204
126SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97000850
127FOXA2_19822575_ChIP-Seq_HepG2_Human0.96997974
128PU1_27457419_Chip-Seq_LIVER_Mouse0.96872066
129E2F1_18555785_Chip-Seq_ESCs_Mouse0.96493583
130CDX2_22108803_ChIP-Seq_LS180_Human0.95762325
131AR_21572438_ChIP-Seq_LNCaP_Human0.95094966
132EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.94532821
133P53_22127205_ChIP-Seq_FIBROBLAST_Human0.93611371
134RUNX1_26923725_Chip-Seq_HPCs_Mouse0.93102894
135CJUN_26792858_Chip-Seq_BT549_Human0.92541939
136CTBP2_25329375_ChIP-Seq_LNCAP_Human0.92050890
137SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91497744
138ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.91026014
139CDX2_19796622_ChIP-Seq_MESCs_Mouse0.89973211
140CTCF_18555785_Chip-Seq_ESCs_Mouse0.89791518
141GF1_26923725_Chip-Seq_HPCs_Mouse0.89517238
142CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88960822
143CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.88676059
144KLF4_18555785_Chip-Seq_ESCs_Mouse0.88082224
145TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87988299
146TBX20_22328084_ChIP-Seq_HEART_Mouse0.87443754
147TBX20_22080862_ChIP-Seq_HEART_Mouse0.87443754
148NFYB_21822215_ChIP-Seq_K562_Human0.86905336
149CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.86899836
150TCF4_23295773_ChIP-Seq_U87_Human0.86645687
151NMYC_18555785_Chip-Seq_ESCs_Mouse0.86544411
152OCT1_27270436_Chip-Seq_PROSTATE_Human0.86091690

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization9.67702629
2MP0003763_abnormal_thymus_physiology3.78115737
3MP0002139_abnormal_hepatobiliary_system3.67062904
4MP0003646_muscle_fatigue3.65216756
5MP0005365_abnormal_bile_salt3.41858076
6MP0005360_urolithiasis3.40762965
7MP0003698_abnormal_male_reproductive3.27458139
8MP0010368_abnormal_lymphatic_system3.14226581
9MP0005670_abnormal_white_adipose3.04463021
10MP0001929_abnormal_gametogenesis2.96999224
11MP0008057_abnormal_DNA_replication2.90251310
12MP0005085_abnormal_gallbladder_physiolo2.71879738
13MP0008260_abnormal_autophagy2.64787226
14MP0003787_abnormal_imprinting2.50692383
15MP0001800_abnormal_humoral_immune2.44380913
16MP0001851_eye_inflammation2.40960013
17MP0005671_abnormal_response_to2.37676830
18MP0010329_abnormal_lipoprotein_level2.29836032
19MP0002009_preneoplasia1.93597120
20MP0000703_abnormal_thymus_morphology1.93040572
21MP0004381_abnormal_hair_follicle1.91814700
22MP0008961_abnormal_basal_metabolism1.89633485
23MP0005000_abnormal_immune_tolerance1.89591330
24MP0002161_abnormal_fertility/fecundity1.85656282
25MP0002723_abnormal_immune_serum1.80834948
26MP0002933_joint_inflammation1.79111809
27MP0004130_abnormal_muscle_cell1.74051033
28MP0003252_abnormal_bile_duct1.71088869
29MP0004142_abnormal_muscle_tone1.70916847
30MP0001879_abnormal_lymphatic_vessel1.70893284
31MP0006082_CNS_inflammation1.68016560
32MP0002420_abnormal_adaptive_immunity1.65682086
33MP0003300_gastrointestinal_ulcer1.64371821
34MP0004145_abnormal_muscle_electrophysio1.64121811
35MP0005174_abnormal_tail_pigmentation1.59872910
36MP0004484_altered_response_of1.59447003
37MP0002398_abnormal_bone_marrow1.58470648
38MP0000569_abnormal_digit_pigmentation1.58266423
39MP0001819_abnormal_immune_cell1.57929767
40MP0008875_abnormal_xenobiotic_pharmacok1.56265326
41MP0002452_abnormal_antigen_presenting1.56004263
42MP0000015_abnormal_ear_pigmentation1.55414648
43MP0002210_abnormal_sex_determination1.52423371
44MP0009697_abnormal_copulation1.49528789
45MP0003724_increased_susceptibility_to1.47570734
46MP0005647_abnormal_sex_gland1.43099530
47MP0002102_abnormal_ear_morphology1.41679006
48MP0009764_decreased_sensitivity_to1.40788466
49MP0000716_abnormal_immune_system1.40511848
50MP0004510_myositis1.39720140
51MP0000609_abnormal_liver_physiology1.36923192
52MP0003806_abnormal_nucleotide_metabolis1.36596963
53MP0003183_abnormal_peptide_metabolism1.35781231
54MP0000689_abnormal_spleen_morphology1.34701649
55MP0005025_abnormal_response_to1.33689293
56MP0002332_abnormal_exercise_endurance1.29960097
57MP0002722_abnormal_immune_system1.29483598
58MP0009384_cardiac_valve_regurgitation1.29312639
59MP0005310_abnormal_salivary_gland1.28774249
60MP0001790_abnormal_immune_system1.25726664
61MP0005387_immune_system_phenotype1.25726664
62MP0009840_abnormal_foam_cell1.25260023
63MP0002638_abnormal_pupillary_reflex1.24333426
64MP0005075_abnormal_melanosome_morpholog1.23811574
65MP0000733_abnormal_muscle_development1.23722129
66MP0002118_abnormal_lipid_homeostasis1.23493812
67MP0003690_abnormal_glial_cell1.21900989
68MP0005397_hematopoietic_system_phenotyp1.21592881
69MP0001545_abnormal_hematopoietic_system1.21592881
70MP0001145_abnormal_male_reproductive1.19108879
71MP0000653_abnormal_sex_gland1.18624989
72MP0000465_gastrointestinal_hemorrhage1.14556894
73MP0005253_abnormal_eye_physiology1.14524628
74MP0005666_abnormal_adipose_tissue1.14248533
75MP0004947_skin_inflammation1.11572594
76MP0002405_respiratory_system_inflammati1.11353140
77MP0004924_abnormal_behavior1.11197702
78MP0005386_behavior/neurological_phenoty1.11197702
79MP0002277_abnormal_respiratory_mucosa1.09166267
80MP0003279_aneurysm1.06473231
81MP0003656_abnormal_erythrocyte_physiolo1.06177998
82MP0009115_abnormal_fat_cell1.04734861
83MP0002971_abnormal_brown_adipose1.03338824
84MP0003868_abnormal_feces_composition1.01904814
85MP0002928_abnormal_bile_duct1.01247595
86MP0003828_pulmonary_edema1.01246860
87MP0000767_abnormal_smooth_muscle1.00857633
88MP0003221_abnormal_cardiomyocyte_apopto1.00732949
89MP0001853_heart_inflammation0.98288670
90MP0000778_abnormal_nervous_system0.97946773
91MP0002653_abnormal_ependyma_morphology0.97640504
92MP0008877_abnormal_DNA_methylation0.97024431
93MP0009278_abnormal_bone_marrow0.95645592
94MP0005076_abnormal_cell_differentiation0.95480057
95MP0002166_altered_tumor_susceptibility0.95437630
96MP0005319_abnormal_enzyme/_coenzyme0.94465552
97MP0010386_abnormal_urinary_bladder0.94410740
98MP0008995_early_reproductive_senescence0.93259884
99MP0004036_abnormal_muscle_relaxation0.92949461
100MP0005167_abnormal_blood-brain_barrier0.92908912
101MP0002254_reproductive_system_inflammat0.92260747
102MP0006276_abnormal_autonomic_nervous0.92228917
103MP0001835_abnormal_antigen_presentation0.91930393
104MP0003091_abnormal_cell_migration0.91576045
105MP0003866_abnormal_defecation0.91430732
106MP0002106_abnormal_muscle_physiology0.90982106
107MP0004087_abnormal_muscle_fiber0.90534054
108MP0002282_abnormal_trachea_morphology0.89937272
109MP0002006_tumorigenesis0.87508240
110MP0001873_stomach_inflammation0.87284217
111MP0002108_abnormal_muscle_morphology0.87105149
112MP0002429_abnormal_blood_cell0.87027344
113MP0001486_abnormal_startle_reflex0.86367967
114MP0000749_muscle_degeneration0.85591651
115MP0005187_abnormal_penis_morphology0.85107534
116MP0003880_abnormal_central_pattern0.84582568
117MP0002269_muscular_atrophy0.83566561
118MP0002138_abnormal_hepatobiliary_system0.83506244
119MP0001915_intracranial_hemorrhage0.83299014
120MP0005332_abnormal_amino_acid0.82852024
121MP0001529_abnormal_vocalization0.82609867
122MP0002067_abnormal_sensory_capabilities0.82314257
123MP0001661_extended_life_span0.80910958
124MP0009763_increased_sensitivity_to0.80349821
125MP0001191_abnormal_skin_condition0.80171475
126MP0003943_abnormal_hepatobiliary_system0.79922717
127MP0003436_decreased_susceptibility_to0.79858781
128MP0003121_genomic_imprinting0.79840724
129MP0001764_abnormal_homeostasis0.79486074
130MP0002419_abnormal_innate_immunity0.79387227
131MP0010630_abnormal_cardiac_muscle0.79275147
132MP0003011_delayed_dark_adaptation0.78614541
133MP0004134_abnormal_chest_morphology0.78519834
134MP0001845_abnormal_inflammatory_respons0.78507949
135MP0005623_abnormal_meninges_morphology0.77795927
136MP0000249_abnormal_blood_vessel0.77036930
137MP0001270_distended_abdomen0.76405754
138MP0002396_abnormal_hematopoietic_system0.74925992
139MP0005646_abnormal_pituitary_gland0.74877990
140MP0000566_synostosis0.74578963
141MP0000751_myopathy0.74440606
142MP0005408_hypopigmentation0.74282519
143MP0002128_abnormal_blood_circulation0.74262753
144MP0005369_muscle_phenotype0.73578769
145MP0002095_abnormal_skin_pigmentation0.73512057
146MP0003303_peritoneal_inflammation0.72848839
147MP0008469_abnormal_protein_level0.72287503
148MP0003699_abnormal_female_reproductive0.72279935
149MP0009785_altered_susceptibility_to0.71834918
150MP0003045_fibrosis0.71521909
151MP0006138_congestive_heart_failure0.70776545
152MP0000372_irregular_coat_pigmentation0.70749361
153MP0006035_abnormal_mitochondrial_morpho0.69603547
154MP0005266_abnormal_metabolism0.69230205
155MP0001986_abnormal_taste_sensitivity0.68607232
156MP0000685_abnormal_immune_system0.68157877
157MP0004270_analgesia0.67047128
158MP0004808_abnormal_hematopoietic_stem0.66959853
159MP0000598_abnormal_liver_morphology0.66535556
160MP0003635_abnormal_synaptic_transmissio0.66496413
161MP0010307_abnormal_tumor_latency0.65820919
162MP0009046_muscle_twitch0.64072242
163MP0009745_abnormal_behavioral_response0.63164498
164MP0004883_abnormal_blood_vessel0.63145509
165MP0010155_abnormal_intestine_physiology0.62617011
166MP0004019_abnormal_vitamin_homeostasis0.62355955
167MP0005620_abnormal_muscle_contractility0.62219661
168MP0008004_abnormal_stomach_pH0.60902723
169MP0000759_abnormal_skeletal_muscle0.60827535
170MP0002127_abnormal_cardiovascular_syste0.59850174
171MP0000343_altered_response_to0.59235317

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)8.10840946
2Absent/shortened dynein arms (HP:0200106)8.10840946
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.91265470
4Abnormal respiratory motile cilium physiology (HP:0012261)5.10189677
5Recurrent abscess formation (HP:0002722)5.06013476
6Abnormal respiratory motile cilium morphology (HP:0005938)4.69077257
7Abnormal respiratory epithelium morphology (HP:0012253)4.69077257
8Periodontitis (HP:0000704)4.48751892
9Prolonged partial thromboplastin time (HP:0003645)4.36632813
10Nasal polyposis (HP:0100582)4.34407881
11Abnormality of T cell number (HP:0011839)4.31697638
12Gingivitis (HP:0000230)4.17695837
13Infertility (HP:0000789)4.11561299
14Leukocytosis (HP:0001974)4.05704684
15Joint hemorrhage (HP:0005261)3.89653555
16Abnormal delayed hypersensitivity skin test (HP:0002963)3.87686608
17Abnormality of the nasal mucosa (HP:0000433)3.87202701
18Rhinitis (HP:0012384)3.85575032
19Chronic bronchitis (HP:0004469)3.83792020
20T lymphocytopenia (HP:0005403)3.78094430
21Hyperlipoproteinemia (HP:0010980)3.71605794
22Abnormal ciliary motility (HP:0012262)3.67441365
23Deep venous thrombosis (HP:0002625)3.46549320
24Hypoalphalipoproteinemia (HP:0003233)3.45054655
25Stomatitis (HP:0010280)3.43522485
26Autoimmune hemolytic anemia (HP:0001890)3.27065688
27Deep philtrum (HP:0002002)3.16358038
28Papilledema (HP:0001085)3.11512965
29Eosinophilia (HP:0001880)3.11442569
30Sparse scalp hair (HP:0002209)3.02604774
31Male infertility (HP:0003251)3.00088856
32Genetic anticipation (HP:0003743)2.98913735
33Abnormality of the intervertebral disk (HP:0005108)2.97624863
34Complement deficiency (HP:0004431)2.93583561
35Bronchitis (HP:0012387)2.88315283
36Xanthomatosis (HP:0000991)2.87120242
37Abnormality of eosinophils (HP:0001879)2.83154614
38Intrahepatic cholestasis (HP:0001406)2.75862184
39Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.75253472
40Spontaneous abortion (HP:0005268)2.68534768
41Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.67910018
42Volvulus (HP:0002580)2.66146401
43Amyotrophic lateral sclerosis (HP:0007354)2.65220813
44Hypolipoproteinemia (HP:0010981)2.65092318
45Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.64997906
46Hyperventilation (HP:0002883)2.64985655
47Hypercholesterolemia (HP:0003124)2.63670039
48Abnormality of the common coagulation pathway (HP:0010990)2.61856105
49Abnormal spermatogenesis (HP:0008669)2.61653086
50Eczematoid dermatitis (HP:0000976)2.60859710
51Epidermoid cyst (HP:0200040)2.59807816
52Abnormality of T cells (HP:0002843)2.56046765
53Recurrent bacterial skin infections (HP:0005406)2.55209349
54Recurrent gram-negative bacterial infections (HP:0005420)2.53013766
55Autoimmune thrombocytopenia (HP:0001973)2.52509410
56Exercise-induced myalgia (HP:0003738)2.52001281
57Hemorrhage of the eye (HP:0011885)2.51350675
58Granulocytopenia (HP:0001913)2.50501334
59Tubulointerstitial nephritis (HP:0001970)2.46477844
60Increased IgM level (HP:0003496)2.43747415
61Papillary thyroid carcinoma (HP:0002895)2.38667873
62Recurrent sinusitis (HP:0011108)2.37096906
63Hemiplegia (HP:0002301)2.36844779
64Recurrent otitis media (HP:0000403)2.32570524
65Bronchiectasis (HP:0002110)2.32293065
66Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.30470015
67Panhypogammaglobulinemia (HP:0003139)2.29961153
68Bile duct proliferation (HP:0001408)2.28634482
69Abnormal biliary tract physiology (HP:0012439)2.28634482
70Febrile seizures (HP:0002373)2.27630821
71Myocardial infarction (HP:0001658)2.26000598
72Rimmed vacuoles (HP:0003805)2.25785079
73Truncal obesity (HP:0001956)2.25522586
74Recurrent bronchitis (HP:0002837)2.24664125
75Neoplasm of the tracheobronchial system (HP:0100552)2.24082965
76Abnormality of the intrinsic pathway (HP:0010989)2.23422061
77Esophageal varix (HP:0002040)2.20339582
78Tetraparesis (HP:0002273)2.20044356
79Progressive cerebellar ataxia (HP:0002073)2.19225600
80Vascular calcification (HP:0004934)2.17746935
81Recurrent fungal infections (HP:0002841)2.16070206
82Abnormality of the frontal sinuses (HP:0002687)2.13417959
83Menstrual irregularities (HP:0000858)2.12169749
84Cone-rod dystrophy (HP:0000548)2.11951025
85Hyperkalemia (HP:0002153)2.11549787
86Fetal akinesia sequence (HP:0001989)2.11264280
87Nephronophthisis (HP:0000090)2.06438017
88Hypoplasia of the thymus (HP:0000778)2.06340138
89Optic neuritis (HP:0100653)2.04992574
90Retrobulbar optic neuritis (HP:0100654)2.04992574
91Heterotopia (HP:0002282)2.04637081
92Cardiovascular calcification (HP:0011915)2.03685832
93Abnormality of complement system (HP:0005339)2.03395100
94Tubulointerstitial abnormality (HP:0001969)2.03313361
95Widely spaced teeth (HP:0000687)2.02742662
96Subaortic stenosis (HP:0001682)2.02566140
97Abnormality of the left ventricular outflow tract (HP:0011103)2.02566140
98Encephalitis (HP:0002383)2.02462858
99Nasal speech (HP:0001611)2.00915817
100Stomach cancer (HP:0012126)2.00568183
101Alveolar cell carcinoma (HP:0006519)1.98694959
102Spontaneous hematomas (HP:0007420)1.95109375
103Elevated erythrocyte sedimentation rate (HP:0003565)1.94822598
104Excessive salivation (HP:0003781)1.94463410
105Thyroiditis (HP:0100646)1.93750465
106Hypobetalipoproteinemia (HP:0003563)1.93698778
107Asymmetric septal hypertrophy (HP:0001670)1.93408690
108Fair hair (HP:0002286)1.93090781
109Gingival bleeding (HP:0000225)1.90065003
110Muscle fiber inclusion bodies (HP:0100299)1.89842425
111Keratoconjunctivitis sicca (HP:0001097)1.89203641
112Pancreatic cysts (HP:0001737)1.89064432
113Orchitis (HP:0100796)1.88856608
114Azoospermia (HP:0000027)1.88120613
115Absent hand (HP:0004050)1.87922438
116Impaired vibratory sensation (HP:0002495)1.87253749
117Chest pain (HP:0100749)1.87165507
118Chronic hepatic failure (HP:0100626)1.87068420
119Vasculitis (HP:0002633)1.87058071
120Ulnar deviation of the wrist (HP:0003049)1.86907116
121Exercise-induced muscle cramps (HP:0003710)1.85778639
122Muscle fiber splitting (HP:0003555)1.85627110
123Myositis (HP:0100614)1.84251958
124Pulmonic stenosis (HP:0001642)1.83360376
125Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.82857921
126Neonatal hypoglycemia (HP:0001998)1.82128629
127Abnormality of T cell physiology (HP:0011840)1.80740763
128Hip dysplasia (HP:0001385)1.80634765
129Abnormality of monocarboxylic acid metabolism (HP:0010996)1.80294642
130Keratoconjunctivitis (HP:0001096)1.79909730
131Difficulty running (HP:0009046)1.79603430
132Drooling (HP:0002307)1.78928236
133Protruding tongue (HP:0010808)1.78522418
134Gaze-evoked nystagmus (HP:0000640)1.77950226
135Attenuation of retinal blood vessels (HP:0007843)1.77042689
136Acute myeloid leukemia (HP:0004808)1.76286761
137Slow saccadic eye movements (HP:0000514)1.75963428
138Thrombophlebitis (HP:0004418)1.75232737
139Recurrent cutaneous fungal infections (HP:0011370)1.74988871
140Chronic mucocutaneous candidiasis (HP:0002728)1.74988871
141Pancreatic fibrosis (HP:0100732)1.74078392
142Ketosis (HP:0001946)1.73813686
143Microcytic anemia (HP:0001935)1.73085461
144Cholecystitis (HP:0001082)1.72688144
145Abnormal gallbladder physiology (HP:0012438)1.72688144
146Cortical dysplasia (HP:0002539)1.71964791
147Hypoproteinemia (HP:0003075)1.71551809
148Long clavicles (HP:0000890)1.70326035
149Absent frontal sinuses (HP:0002688)1.69695645
150Hypochromic anemia (HP:0001931)1.69636419
151Pulmonary embolism (HP:0002204)1.69515610
152Portal hypertension (HP:0001409)1.69059443
153Myopathic facies (HP:0002058)1.68890828
154Abnormality of cells of the lymphoid lineage (HP:0012140)1.68759448
155Congenital hepatic fibrosis (HP:0002612)1.68140436
156Polycythemia (HP:0001901)1.66798802
157Inappropriate behavior (HP:0000719)1.66775455
158Meningitis (HP:0001287)1.66362179
159Hyporeflexia of lower limbs (HP:0002600)1.65818013
160Facial diplegia (HP:0001349)1.65429657
161Abnormality of glutamine family amino acid metabolism (HP:0010902)1.65033382
162Abnormality of the hepatic vasculature (HP:0006707)1.64559973
163Arterial thrombosis (HP:0004420)1.64161439
164Absent speech (HP:0001344)1.62403056
165Spastic tetraparesis (HP:0001285)1.61172481
166Abnormality of the columella (HP:0009929)1.60600076
167Stroke (HP:0001297)1.59985449
168Frequent falls (HP:0002359)1.57054324
169Abnormality of sulfur amino acid metabolism (HP:0004339)1.55777163
170Abnormality of aromatic amino acid family metabolism (HP:0004338)1.55749981
171Abnormality of the renal medulla (HP:0100957)1.55268638
172Tubular atrophy (HP:0000092)1.54925599
173Nemaline bodies (HP:0003798)1.54454305
174Distal arthrogryposis (HP:0005684)1.53802448
175Impulsivity (HP:0100710)1.53094199
176Rhabdomyolysis (HP:0003201)1.52288852
177Gastrointestinal infarctions (HP:0005244)1.51907850

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK45.70019660
2PDK35.70019660
3TIE15.47667209
4PDK23.73700942
5TXK3.03975141
6FRK2.85409946
7ICK2.83332354
8CAMK1D2.70038962
9PRKCH2.61341865
10CAMK1G2.60240608
11TESK12.57573547
12MAP4K12.53291776
13FES2.40534686
14LATS12.37554779
15PRKD32.31098258
16NLK2.16210551
17TNIK2.01943012
18CASK1.86936621
19CSK1.73149579
20MAP3K41.73089722
21SIK11.65325605
22INSRR1.57978002
23OBSCN1.53890114
24KSR11.53609765
25MAP4K21.52374135
26NEK91.49414678
27MAP3K21.49307000
28NTRK31.46020786
29MAP3K61.45889086
30ERN11.45163270
31STK31.43979006
32FGFR41.42695265
33MUSK1.41046272
34BRD41.39087418
35MAPK131.32602796
36CAMKK21.31898193
37TYK21.30497262
38PNCK1.29873549
39PTK2B1.25292933
40ERBB41.23418758
41PBK1.21601199
42TAOK31.21301468
43LCK1.21234044
44CDK121.20507790
45WNK11.15469663
46TBK11.13613435
47AKT31.13433939
48TEC1.13022234
49BLK1.12625028
50PRKAA21.10783007
51JAK11.10714127
52PRKAA11.09795358
53EPHB21.08081575
54KIT1.07985291
55BTK1.07716870
56SYK1.06605420
57JAK31.06135786
58STK381.05343280
59MARK11.04312720
60CCNB10.99979630
61MAP3K100.97285772
62WNK30.96664637
63ITK0.93617109
64YES10.93603629
65NEK20.93117073
66STK110.91226788
67FGR0.91014114
68MAP3K140.87547134
69SIK30.87432053
70PDK10.85920727
71FGFR20.83721030
72CSF1R0.83655605
73SGK4940.81570297
74SGK2230.81570297
75PDGFRB0.81562960
76STK38L0.79904766
77IRAK10.79839671
78RET0.78226473
79MAPK150.77280607
80BMPR1B0.77191051
81MAP2K30.75991699
82ZAP700.75646385
83BMX0.75084296
84RIPK40.74582965
85DYRK1B0.74506975
86TGFBR20.74117636
87TAOK10.73475508
88SIK20.73053104
89PINK10.71415089
90CHUK0.69818655
91MAP3K10.69673772
92PRPF4B0.69294313
93ACVR1B0.68950893
94LYN0.68475138
95IRAK20.67665742
96KDR0.67514004
97MAPK110.67316488
98IKBKE0.67256494
99PLK40.66726111
100ERBB30.66202399
101CDK190.66097355
102NEK60.65300101
103FGFR30.64362493
104TTN0.64153057
105SGK10.62740869
106MAP2K40.62201320
107MTOR0.62127692
108MAPK120.61810870
109MARK30.60044957
110NUAK10.60038447
111RAF10.59067369
112EEF2K0.57248779
113DYRK1A0.56566075
114MAP3K50.55116662
115PDPK10.55001260
116CDK60.53729222
117BMPR20.51575709
118PIM10.51285057
119MARK20.49595094
120RIPK10.49518073
121ERBB20.48227819
122JAK20.47685556
123SGK20.46341771
124IRAK40.46090889
125GRK60.45947381
126TNK20.45695650
127NTRK20.43373274
128UHMK10.41472475
129PLK20.41389122
130STK40.41221407
131EPHB10.40811940
132VRK10.39618508
133PRKCQ0.39571183
134MAPK70.39062360
135IKBKB0.38405676
136PHKG10.38002830
137PHKG20.38002830
138EPHA30.37045746
139MST1R0.35071909
140LATS20.33750498
141SGK30.33126668
142CAMK40.32902631
143PIK3CG0.31638297
144MAPK40.31501242
145IGF1R0.30639919
146KSR20.30529426
147ABL20.29614783
148HCK0.28497725
149MAP3K70.26348907
150PRKCZ0.26309505
151PRKACG0.25297925
152EGFR0.23737735
153TYRO30.23559012
154CHEK20.23176469

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.38468933
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.12711740
3Fatty acid biosynthesis_Homo sapiens_hsa000612.88527134
4PPAR signaling pathway_Homo sapiens_hsa033202.70011032
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.56164126
6Complement and coagulation cascades_Homo sapiens_hsa046102.53546575
7Fatty acid degradation_Homo sapiens_hsa000712.45943566
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.26251836
9T cell receptor signaling pathway_Homo sapiens_hsa046602.15863677
10Primary immunodeficiency_Homo sapiens_hsa053402.07350494
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.99267123
12Arginine biosynthesis_Homo sapiens_hsa002201.99053083
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.97783717
14Fatty acid metabolism_Homo sapiens_hsa012121.95727603
15Propanoate metabolism_Homo sapiens_hsa006401.88250802
16Non-small cell lung cancer_Homo sapiens_hsa052231.83210020
17Dorso-ventral axis formation_Homo sapiens_hsa043201.81984916
18Staphylococcus aureus infection_Homo sapiens_hsa051501.80382613
19Vitamin B6 metabolism_Homo sapiens_hsa007501.73591933
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.64276155
21Bile secretion_Homo sapiens_hsa049761.64192118
22Graft-versus-host disease_Homo sapiens_hsa053321.63872543
23Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.57461070
24Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.55019891
25FoxO signaling pathway_Homo sapiens_hsa040681.53796355
26Autoimmune thyroid disease_Homo sapiens_hsa053201.52691492
27Tryptophan metabolism_Homo sapiens_hsa003801.47703852
28Peroxisome_Homo sapiens_hsa041461.45438263
29Allograft rejection_Homo sapiens_hsa053301.44592090
30Selenocompound metabolism_Homo sapiens_hsa004501.44126475
31Colorectal cancer_Homo sapiens_hsa052101.40930085
32Phosphatidylinositol signaling system_Homo sapiens_hsa040701.40582559
33Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.40577961
34ABC transporters_Homo sapiens_hsa020101.38657656
35Lysine degradation_Homo sapiens_hsa003101.32041744
36Glucagon signaling pathway_Homo sapiens_hsa049221.31487825
37Adipocytokine signaling pathway_Homo sapiens_hsa049201.28938860
38Type I diabetes mellitus_Homo sapiens_hsa049401.24311622
39Endometrial cancer_Homo sapiens_hsa052131.24182487
40Choline metabolism in cancer_Homo sapiens_hsa052311.24101725
41Pentose phosphate pathway_Homo sapiens_hsa000301.20715752
42Pyruvate metabolism_Homo sapiens_hsa006201.19235707
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.15038713
44Chemokine signaling pathway_Homo sapiens_hsa040621.14452650
45Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.11759408
46Insulin resistance_Homo sapiens_hsa049311.11113119
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.09903922
48Caffeine metabolism_Homo sapiens_hsa002321.08498227
49Prolactin signaling pathway_Homo sapiens_hsa049171.08247673
50Chronic myeloid leukemia_Homo sapiens_hsa052201.08104269
51mTOR signaling pathway_Homo sapiens_hsa041501.05165821
52Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.04793446
53Hematopoietic cell lineage_Homo sapiens_hsa046401.04460691
54Pancreatic cancer_Homo sapiens_hsa052121.03375730
55Type II diabetes mellitus_Homo sapiens_hsa049301.02855121
56Pentose and glucuronate interconversions_Homo sapiens_hsa000401.02284690
57Renal cell carcinoma_Homo sapiens_hsa052111.01820250
58ErbB signaling pathway_Homo sapiens_hsa040121.01792727
59Long-term potentiation_Homo sapiens_hsa047201.01498300
60Long-term depression_Homo sapiens_hsa047301.01370231
61Tuberculosis_Homo sapiens_hsa051521.01240192
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.99823926
63Glioma_Homo sapiens_hsa052140.95822706
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.95602561
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94553461
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.94311215
67Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.94294011
68Starch and sucrose metabolism_Homo sapiens_hsa005000.94071103
69Glycerolipid metabolism_Homo sapiens_hsa005610.94022396
70Vitamin digestion and absorption_Homo sapiens_hsa049770.93001563
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.92856469
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91808823
73Platelet activation_Homo sapiens_hsa046110.91716737
74Cholinergic synapse_Homo sapiens_hsa047250.90910582
75Circadian rhythm_Homo sapiens_hsa047100.90033366
76Regulation of autophagy_Homo sapiens_hsa041400.89443054
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.88472676
78Leishmaniasis_Homo sapiens_hsa051400.87653265
79Prostate cancer_Homo sapiens_hsa052150.86454710
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.86215418
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85607416
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.85541887
83RNA polymerase_Homo sapiens_hsa030200.84680056
84Ras signaling pathway_Homo sapiens_hsa040140.84308309
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83736027
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.82417804
87Inositol phosphate metabolism_Homo sapiens_hsa005620.82297672
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82065810
89Cysteine and methionine metabolism_Homo sapiens_hsa002700.81751256
90TNF signaling pathway_Homo sapiens_hsa046680.80885096
91Malaria_Homo sapiens_hsa051440.80722587
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80493281
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.80344721
94Pertussis_Homo sapiens_hsa051330.80339604
95MAPK signaling pathway_Homo sapiens_hsa040100.79605745
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.79288578
97Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78223856
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77727388
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77393867
100Influenza A_Homo sapiens_hsa051640.77334483
101Nicotine addiction_Homo sapiens_hsa050330.77311193
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.74680356
103Rap1 signaling pathway_Homo sapiens_hsa040150.71999849
104AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71938638
105Chemical carcinogenesis_Homo sapiens_hsa052040.71087435
106Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70756298
107Steroid hormone biosynthesis_Homo sapiens_hsa001400.70438691
108Morphine addiction_Homo sapiens_hsa050320.70324130
109Retinol metabolism_Homo sapiens_hsa008300.70218343
110Olfactory transduction_Homo sapiens_hsa047400.69901632
111Glycosaminoglycan degradation_Homo sapiens_hsa005310.69873719
112VEGF signaling pathway_Homo sapiens_hsa043700.68763012
113Carbon metabolism_Homo sapiens_hsa012000.68081824
114NF-kappa B signaling pathway_Homo sapiens_hsa040640.67964861
115Phototransduction_Homo sapiens_hsa047440.65825012
116Basal transcription factors_Homo sapiens_hsa030220.65413858
117Toxoplasmosis_Homo sapiens_hsa051450.65029132
118Measles_Homo sapiens_hsa051620.64650089
119Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63526497
120Biosynthesis of amino acids_Homo sapiens_hsa012300.63519557
121Osteoclast differentiation_Homo sapiens_hsa043800.62103487
122Oxytocin signaling pathway_Homo sapiens_hsa049210.60850938
123Legionellosis_Homo sapiens_hsa051340.60732024
124Herpes simplex infection_Homo sapiens_hsa051680.60493662
125Drug metabolism - other enzymes_Homo sapiens_hsa009830.58776872
126Viral myocarditis_Homo sapiens_hsa054160.58378171
127beta-Alanine metabolism_Homo sapiens_hsa004100.58317040
128Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57376971
129Notch signaling pathway_Homo sapiens_hsa043300.57310536
130Viral carcinogenesis_Homo sapiens_hsa052030.57017287
131AMPK signaling pathway_Homo sapiens_hsa041520.56666190
132Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56589047
133Fructose and mannose metabolism_Homo sapiens_hsa000510.56233716
134B cell receptor signaling pathway_Homo sapiens_hsa046620.56152317
135Calcium signaling pathway_Homo sapiens_hsa040200.55311260
136Fat digestion and absorption_Homo sapiens_hsa049750.55120601
137cAMP signaling pathway_Homo sapiens_hsa040240.54251525
138Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53232616
139Circadian entrainment_Homo sapiens_hsa047130.52257996
140Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.51838781
141HTLV-I infection_Homo sapiens_hsa051660.51207001
142Dopaminergic synapse_Homo sapiens_hsa047280.50942248
143Sulfur relay system_Homo sapiens_hsa041220.47038460
144Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46348498
145Central carbon metabolism in cancer_Homo sapiens_hsa052300.46001331
146Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45274901
147Jak-STAT signaling pathway_Homo sapiens_hsa046300.44823047
148Butanoate metabolism_Homo sapiens_hsa006500.41380392
149HIF-1 signaling pathway_Homo sapiens_hsa040660.41368834
150Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.40883891
151Linoleic acid metabolism_Homo sapiens_hsa005910.37115416
152NOD-like receptor signaling pathway_Homo sapiens_hsa046210.35751578
153Adherens junction_Homo sapiens_hsa045200.34231436
154Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33269164
155Ovarian steroidogenesis_Homo sapiens_hsa049130.31840554
156Insulin signaling pathway_Homo sapiens_hsa049100.26521228
157Acute myeloid leukemia_Homo sapiens_hsa052210.26347374
158Phenylalanine metabolism_Homo sapiens_hsa003600.25414787
159Histidine metabolism_Homo sapiens_hsa003400.25126715
160Small cell lung cancer_Homo sapiens_hsa052220.23982714
161African trypanosomiasis_Homo sapiens_hsa051430.22222242
162cGMP-PKG signaling pathway_Homo sapiens_hsa040220.22130044
163Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.22036315
164Prion diseases_Homo sapiens_hsa050200.21083325
165Renin-angiotensin system_Homo sapiens_hsa046140.21078032
166Hepatitis B_Homo sapiens_hsa051610.20165222
167Intestinal immune network for IgA production_Homo sapiens_hsa046720.20027204

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