CEP89

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.70644070
2ribosome assembly (GO:0042255)5.44810669
3proteasome assembly (GO:0043248)5.34725914
4regulation of nuclear cell cycle DNA replication (GO:0033262)4.76838783
5DNA replication checkpoint (GO:0000076)4.66232353
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.56849293
7behavioral response to nicotine (GO:0035095)4.50145181
8transcription elongation from RNA polymerase III promoter (GO:0006385)4.36760183
9termination of RNA polymerase III transcription (GO:0006386)4.36760183
10rRNA modification (GO:0000154)4.33572247
11telomere maintenance via semi-conservative replication (GO:0032201)4.33224212
12deoxyribonucleotide biosynthetic process (GO:0009263)4.27705002
13mitotic metaphase plate congression (GO:0007080)4.25003776
14deoxyribonucleoside diphosphate metabolic process (GO:0009186)4.12258692
15DNA strand elongation involved in DNA replication (GO:0006271)4.11194070
16epithelial cilium movement (GO:0003351)4.10280145
17ribosome biogenesis (GO:0042254)4.04990985
18ribosomal large subunit biogenesis (GO:0042273)4.00888331
19mitochondrial DNA replication (GO:0006264)4.00736619
20DNA damage response, detection of DNA damage (GO:0042769)4.00642780
21cilium movement (GO:0003341)3.95791096
22ribonucleoprotein complex biogenesis (GO:0022613)3.94148230
23pyrimidine nucleobase catabolic process (GO:0006208)3.93762076
24DNA strand elongation (GO:0022616)3.88942880
25telomere maintenance via recombination (GO:0000722)3.86415983
26DNA-dependent DNA replication (GO:0006261)3.85244117
27DNA replication initiation (GO:0006270)3.85094210
28regulation of cilium movement (GO:0003352)3.83494470
29negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.81969713
30maturation of SSU-rRNA (GO:0030490)3.81831196
31ribosomal small subunit biogenesis (GO:0042274)3.79718742
32CENP-A containing nucleosome assembly (GO:0034080)3.79502492
33nonmotile primary cilium assembly (GO:0035058)3.79492825
34anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.79184462
35kinetochore assembly (GO:0051382)3.78782428
36positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.76063578
37chromatin remodeling at centromere (GO:0031055)3.75355904
38regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.72987004
39regulation of centriole replication (GO:0046599)3.71099411
40maturation of 5.8S rRNA (GO:0000460)3.67366191
41regulation of double-strand break repair via homologous recombination (GO:0010569)3.64958571
42protein-cofactor linkage (GO:0018065)3.64850765
43deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.63801745
447-methylguanosine mRNA capping (GO:0006370)3.63753625
45telomere maintenance via telomere lengthening (GO:0010833)3.61204525
46RNA destabilization (GO:0050779)3.58579282
47spliceosomal snRNP assembly (GO:0000387)3.57625259
48presynaptic membrane assembly (GO:0097105)3.57584875
49mitotic recombination (GO:0006312)3.57467509
50metaphase plate congression (GO:0051310)3.57306717
51RNA capping (GO:0036260)3.56416390
527-methylguanosine RNA capping (GO:0009452)3.56416390
53kinetochore organization (GO:0051383)3.53710694
54axoneme assembly (GO:0035082)3.53642743
55transcription-coupled nucleotide-excision repair (GO:0006283)3.49899467
56negative regulation of ligase activity (GO:0051352)3.46925379
57negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.46925379
58rRNA processing (GO:0006364)3.44323448
59postsynaptic membrane organization (GO:0001941)3.43517855
60purine nucleobase biosynthetic process (GO:0009113)3.42311798
61nucleobase biosynthetic process (GO:0046112)3.41080987
62spinal cord development (GO:0021510)3.40343085
63cilium morphogenesis (GO:0060271)3.39179950
64spliceosomal complex assembly (GO:0000245)3.38171282
65rRNA metabolic process (GO:0016072)3.36350914
66olfactory bulb development (GO:0021772)3.36298132
67signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.36106023
68signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.36106023
69signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.36106023
70histone H4-K12 acetylation (GO:0043983)3.35972136
71tachykinin receptor signaling pathway (GO:0007217)3.35838792
72negative regulation of DNA-dependent DNA replication (GO:2000104)3.35533361
73transcription from RNA polymerase I promoter (GO:0006360)3.34964086
74signal transduction involved in DNA integrity checkpoint (GO:0072401)3.33170554
75signal transduction involved in DNA damage checkpoint (GO:0072422)3.33170554
76positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.31872466
77cornea development in camera-type eye (GO:0061303)3.31192506
78regulation of cellular amino acid metabolic process (GO:0006521)3.31038080
79axonemal dynein complex assembly (GO:0070286)3.30910220
80histone exchange (GO:0043486)3.30435295
81signal transduction involved in cell cycle checkpoint (GO:0072395)3.29614415
82presynaptic membrane organization (GO:0097090)3.26674271
83detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.26277926
84termination of RNA polymerase I transcription (GO:0006363)3.26003327
85negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.24169661
86negative regulation of sister chromatid segregation (GO:0033046)3.24169661
87negative regulation of mitotic sister chromatid separation (GO:2000816)3.24169661
88negative regulation of mitotic sister chromatid segregation (GO:0033048)3.24169661
89DNA replication-independent nucleosome assembly (GO:0006336)3.23639792
90DNA replication-independent nucleosome organization (GO:0034724)3.23639792
91L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.23438350
92pseudouridine synthesis (GO:0001522)3.22233861
93piRNA metabolic process (GO:0034587)3.21792087
94protein polyglutamylation (GO:0018095)3.20495007
95rRNA methylation (GO:0031167)3.19174911
96RNA methylation (GO:0001510)3.19016872
97negative regulation of chromosome segregation (GO:0051985)3.18986635
98cilium or flagellum-dependent cell motility (GO:0001539)3.18530073
99exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.18400175
100synaptonemal complex assembly (GO:0007130)3.18306353
101DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.17464030
102establishment of chromosome localization (GO:0051303)3.17390017
103positive regulation of ligase activity (GO:0051351)3.16697979
104centriole replication (GO:0007099)3.16444256
105mitotic spindle assembly checkpoint (GO:0007094)3.16408270
106deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.15318421
107spindle checkpoint (GO:0031577)3.14416612
108amino acid salvage (GO:0043102)3.14293389
109L-methionine salvage (GO:0071267)3.14293389
110L-methionine biosynthetic process (GO:0071265)3.14293389
111negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.14036783
112spindle assembly checkpoint (GO:0071173)3.13639820
113nucleobase-containing small molecule interconversion (GO:0015949)3.13612152
114regulation of mitochondrial translation (GO:0070129)3.13323323
115regulation of hippo signaling (GO:0035330)3.13048165
116regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.12937114
117transcription elongation from RNA polymerase I promoter (GO:0006362)3.12647676
118regulation of centrosome cycle (GO:0046605)3.12603533
119nucleotide-excision repair, DNA gap filling (GO:0006297)3.12414777
120signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.11796195
121intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.11796195
122behavioral response to ethanol (GO:0048149)3.11605274
123nucleobase catabolic process (GO:0046113)3.09681089
124* cilium organization (GO:0044782)3.07813193
125neuron recognition (GO:0008038)3.06593826
126intraciliary transport (GO:0042073)3.06021207
127negative regulation of response to food (GO:0032096)3.05063506
128negative regulation of appetite (GO:0032099)3.05063506
129replication fork processing (GO:0031297)3.03701958
130* cilium assembly (GO:0042384)3.03060095
131regulation of action potential (GO:0098900)3.01566345
132retinal ganglion cell axon guidance (GO:0031290)2.96337220
133transmission of nerve impulse (GO:0019226)2.92796893
134positive regulation of action potential (GO:0045760)2.91097151
135neural tube formation (GO:0001841)2.90980767
136limb development (GO:0060173)2.90516810
137appendage development (GO:0048736)2.90516810
138response to pheromone (GO:0019236)2.88308268
139negative regulation of axon guidance (GO:1902668)2.83486628
140regulation of microtubule-based movement (GO:0060632)2.82818146
141G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.81780998
142negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.81267749
143negative regulation of translation, ncRNA-mediated (GO:0040033)2.81267749
144regulation of translation, ncRNA-mediated (GO:0045974)2.81267749
145fucose catabolic process (GO:0019317)2.81252107
146L-fucose metabolic process (GO:0042354)2.81252107
147L-fucose catabolic process (GO:0042355)2.81252107
148negative regulation of transcription regulatory region DNA binding (GO:2000678)2.79427952
149indolalkylamine metabolic process (GO:0006586)2.79312466
150axonal fasciculation (GO:0007413)2.76057393
151startle response (GO:0001964)2.70482680
152head development (GO:0060322)2.69577114
153microtubule bundle formation (GO:0001578)2.67870373
154central nervous system projection neuron axonogenesis (GO:0021952)2.67508668
155hindbrain development (GO:0030902)2.66349634
156kynurenine metabolic process (GO:0070189)2.64619164
157photoreceptor cell maintenance (GO:0045494)2.64346519
158cell proliferation in forebrain (GO:0021846)2.63447602
159regulation of timing of cell differentiation (GO:0048505)2.62999325
160central nervous system neuron axonogenesis (GO:0021955)2.59556749
161inner ear receptor stereocilium organization (GO:0060122)2.59071829
162smoothened signaling pathway (GO:0007224)2.57875822
163somite development (GO:0061053)2.56339152
164response to auditory stimulus (GO:0010996)2.55842181
165limb bud formation (GO:0060174)2.53686647
166negative regulation of axon extension involved in axon guidance (GO:0048843)2.52845981
167tryptophan catabolic process (GO:0006569)2.52625914
168indole-containing compound catabolic process (GO:0042436)2.52625914
169indolalkylamine catabolic process (GO:0046218)2.52625914
170negative regulation of telomere maintenance (GO:0032205)2.51576227
171regulation of DNA endoreduplication (GO:0032875)2.49964245
172retinal cone cell development (GO:0046549)2.49577516
173regulation of telomere maintenance (GO:0032204)2.46798052
174auditory behavior (GO:0031223)2.46177685
175regulation of development, heterochronic (GO:0040034)2.45736592
176negative regulation of cytosolic calcium ion concentration (GO:0051481)2.44078512
177* cellular component assembly involved in morphogenesis (GO:0010927)2.43374175
178brain morphogenesis (GO:0048854)2.41653262
179cerebral cortex radially oriented cell migration (GO:0021799)2.40801318
180gamma-aminobutyric acid transport (GO:0015812)2.39735899
181microtubule depolymerization (GO:0007019)2.37988076
182detection of light stimulus involved in visual perception (GO:0050908)2.37648301
183detection of light stimulus involved in sensory perception (GO:0050962)2.37648301
184positive regulation of gastrulation (GO:2000543)2.37343272
185urinary tract smooth muscle contraction (GO:0014848)2.36758903
186regulation of axon guidance (GO:1902667)2.36167744
187determination of left/right symmetry (GO:0007368)2.35162212
188protein localization to cilium (GO:0061512)2.34816726
189mechanosensory behavior (GO:0007638)2.32504020
190synapse assembly (GO:0007416)2.32180423
191protein localization to synapse (GO:0035418)2.31973680
192resolution of meiotic recombination intermediates (GO:0000712)2.30870483
193regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.30861816
194negative regulation of heart rate (GO:0010459)2.30006550
195reflex (GO:0060004)2.29855997
196negative regulation of mast cell activation (GO:0033004)2.28857453
197detection of mechanical stimulus involved in sensory perception (GO:0050974)2.26582641
198water-soluble vitamin biosynthetic process (GO:0042364)2.26231301

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.13511223
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.38147582
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.24117286
4EZH2_22144423_ChIP-Seq_EOC_Human4.13593420
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.78235941
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.66680410
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.65646711
8ZNF274_21170338_ChIP-Seq_K562_Hela3.65534113
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.62346253
10FOXM1_23109430_ChIP-Seq_U2OS_Human3.59146260
11E2F4_17652178_ChIP-ChIP_JURKAT_Human3.46276641
12GBX2_23144817_ChIP-Seq_PC3_Human3.41719223
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.41176711
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.16818134
15CREB1_15753290_ChIP-ChIP_HEK293T_Human3.08015189
16MYC_19079543_ChIP-ChIP_MESCs_Mouse3.05430207
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.04002920
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.01093493
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.99286152
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.98511002
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.93709754
22VDR_22108803_ChIP-Seq_LS180_Human2.88010841
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.80919022
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.64746992
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.63818967
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.53587628
27VDR_23849224_ChIP-Seq_CD4+_Human2.52160883
28ZFP57_27257070_Chip-Seq_ESCs_Mouse2.49358020
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.42716722
30IGF1R_20145208_ChIP-Seq_DFB_Human2.42306749
31CTBP2_25329375_ChIP-Seq_LNCAP_Human2.37449575
32XRN2_22483619_ChIP-Seq_HELA_Human2.34896468
33NELFA_20434984_ChIP-Seq_ESCs_Mouse2.33410483
34ELF1_17652178_ChIP-ChIP_JURKAT_Human2.29145411
35CTBP1_25329375_ChIP-Seq_LNCAP_Human2.24952516
36SALL1_21062744_ChIP-ChIP_HESCs_Human2.21061386
37YY1_21170310_ChIP-Seq_MESCs_Mouse2.20999382
38MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.14737976
39E2F1_18555785_ChIP-Seq_MESCs_Mouse2.13199719
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.12731655
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.05135097
42DCP1A_22483619_ChIP-Seq_HELA_Human2.03272035
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.02699031
44CBX2_27304074_Chip-Seq_ESCs_Mouse2.02153172
45THAP11_20581084_ChIP-Seq_MESCs_Mouse2.01206208
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.99667461
47FOXP3_21729870_ChIP-Seq_TREG_Human1.99356026
48TTF2_22483619_ChIP-Seq_HELA_Human1.99210368
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.96287685
50FUS_26573619_Chip-Seq_HEK293_Human1.95968818
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.95052503
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.92987668
53EWS_26573619_Chip-Seq_HEK293_Human1.91960144
54AR_21572438_ChIP-Seq_LNCaP_Human1.90533833
55P300_19829295_ChIP-Seq_ESCs_Human1.90108073
56TAF15_26573619_Chip-Seq_HEK293_Human1.89332288
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.82559176
58GABP_19822575_ChIP-Seq_HepG2_Human1.80384593
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.78219198
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76838579
61ELK1_19687146_ChIP-ChIP_HELA_Human1.76481251
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76119491
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.74724775
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.66071090
65AR_21909140_ChIP-Seq_LNCAP_Human1.65850545
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65442823
67CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.61699420
68EZH2_27304074_Chip-Seq_ESCs_Mouse1.61638577
69TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61496571
70POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.61496571
71SMAD4_21799915_ChIP-Seq_A2780_Human1.58934869
72IRF1_19129219_ChIP-ChIP_H3396_Human1.57996998
73FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.57425838
74RNF2_27304074_Chip-Seq_NSC_Mouse1.56258508
75STAT3_23295773_ChIP-Seq_U87_Human1.55874939
76ER_23166858_ChIP-Seq_MCF-7_Human1.53833358
77PIAS1_25552417_ChIP-Seq_VCAP_Human1.53783832
78EED_16625203_ChIP-ChIP_MESCs_Mouse1.53487739
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.53131017
80POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.52622455
81NR3C1_21868756_ChIP-Seq_MCF10A_Human1.50731483
82TP63_19390658_ChIP-ChIP_HaCaT_Human1.50224048
83REST_21632747_ChIP-Seq_MESCs_Mouse1.50098443
84TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.49992366
85BMI1_23680149_ChIP-Seq_NPCS_Mouse1.49206511
86KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.47669027
87KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.47669027
88KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.47669027
89SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47119178
90SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.46038025
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.45655423
92CBP_20019798_ChIP-Seq_JUKART_Human1.45342968
93IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45342968
94CIITA_25753668_ChIP-Seq_RAJI_Human1.44751862
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.44366172
96KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.43463940
97PADI4_21655091_ChIP-ChIP_MCF-7_Human1.41092130
98RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39321776
99AR_25329375_ChIP-Seq_VCAP_Human1.38705910
100FLI1_27457419_Chip-Seq_LIVER_Mouse1.38612264
101PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.38455294
102BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.38076727
103EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.38035812
104E2F1_21310950_ChIP-Seq_MCF-7_Human1.35696861
105UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35040722
106BCAT_22108803_ChIP-Seq_LS180_Human1.34235457
107TCF4_23295773_ChIP-Seq_U87_Human1.33398825
108SMAD3_21741376_ChIP-Seq_EPCs_Human1.33355920
109JARID2_20064375_ChIP-Seq_MESCs_Mouse1.33276758
110KDM5A_27292631_Chip-Seq_BREAST_Human1.32905471
111FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.32308748
112ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.29653753
113SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29207230
114TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29111239
115TP53_22573176_ChIP-Seq_HFKS_Human1.29016788
116ZFX_18555785_ChIP-Seq_MESCs_Mouse1.28813899
117CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.27553565
118SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.25668982
119SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.25612361
120NOTCH1_21737748_ChIP-Seq_TLL_Human1.24605665
121ELK1_22589737_ChIP-Seq_MCF10A_Human1.21773126
122POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21398986
123KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.20321486
124HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19075336
125SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17767299
126KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.17309387
127RUNX2_22187159_ChIP-Seq_PCA_Human1.17057184
128PCGF2_27294783_Chip-Seq_ESCs_Mouse1.16513857
129TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15026473
130TCF4_22108803_ChIP-Seq_LS180_Human1.14701670
131KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13338196
132POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.12435769
133SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.12110844
134EZH2_27294783_Chip-Seq_ESCs_Mouse1.10084902
135CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09945995
136DROSHA_22980978_ChIP-Seq_HELA_Human1.09274659
137OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08045209
138SMAD4_21741376_ChIP-Seq_EPCs_Human1.07926565
139GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06600356
140TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06543956
141TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06442855
142TP53_16413492_ChIP-PET_HCT116_Human1.06291006
143CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06061076
144HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.06000589
145RNF2_27304074_Chip-Seq_ESCs_Mouse1.05376335
146NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.05006443
147RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04820627
148FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04681473
149SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02814267
150SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01896444
151SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01846844
152PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.01724501
153TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.00791444
154E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00258132
155ARNT_22903824_ChIP-Seq_MCF-7_Human1.00140337
156STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00019438
157JARID2_20075857_ChIP-Seq_MESCs_Mouse0.99886361
158DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99675816
159FLI1_21867929_ChIP-Seq_TH2_Mouse0.99472663
160NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.98787749
161SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.98321822
162PRDM14_20953172_ChIP-Seq_ESCs_Human0.97868892
163JUN_21703547_ChIP-Seq_K562_Human0.97521508
164SOX2_21211035_ChIP-Seq_LN229_Gbm0.97270042
165AHR_22903824_ChIP-Seq_MCF-7_Human0.97237617
166SOX2_19829295_ChIP-Seq_ESCs_Human0.96808741
167NANOG_19829295_ChIP-Seq_ESCs_Human0.96808741
168PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95921864
169MYC_18940864_ChIP-ChIP_HL60_Human0.95521091
170BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95374004
171REST_18959480_ChIP-ChIP_MESCs_Mouse0.94910756
172CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93501815
173GATA1_26923725_Chip-Seq_HPCs_Mouse0.91370412
174KLF4_18555785_ChIP-Seq_MESCs_Mouse0.90220557
175RBPJ_22232070_ChIP-Seq_NCS_Mouse0.89636940
176YY1_22570637_ChIP-Seq_MALME-3M_Human0.86535258
177SOX17_20123909_ChIP-Seq_XEN_Mouse0.85116241
178CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.81602891
179NANOG_16153702_ChIP-ChIP_HESCs_Human0.79445662
180KAP1_22055183_ChIP-Seq_ESCs_Mouse0.78472671
181GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77540411
182ERG_20887958_ChIP-Seq_HPC-7_Mouse0.77130715
183CTCF_18555785_ChIP-Seq_MESCs_Mouse0.75990000
184HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.75653476
185SOX2_18692474_ChIP-Seq_MEFs_Mouse0.74881665
186CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.74156062
187CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.71218980
188KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.71038783

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.67159916
2MP0003111_abnormal_nucleus_morphology5.00060405
3MP0008058_abnormal_DNA_repair4.14358046
4MP0010094_abnormal_chromosome_stability3.99080147
5MP0008057_abnormal_DNA_replication3.90728308
6MP0003077_abnormal_cell_cycle3.73727618
7MP0008877_abnormal_DNA_methylation3.68623600
8MP0004957_abnormal_blastocyst_morpholog3.68598985
9MP0003718_maternal_effect3.12120905
10MP0008932_abnormal_embryonic_tissue3.09520224
11MP0008007_abnormal_cellular_replicative3.07859168
12MP0003786_premature_aging2.92130535
13MP0002736_abnormal_nociception_after2.45560911
14MP0000778_abnormal_nervous_system2.39449038
15MP0002160_abnormal_reproductive_system2.35272798
16MP0003880_abnormal_central_pattern2.33531531
17MP0001968_abnormal_touch/_nociception2.31923400
18MP0003941_abnormal_skin_development2.29723482
19MP0000569_abnormal_digit_pigmentation2.29331541
20MP0001529_abnormal_vocalization2.24360901
21MP0006276_abnormal_autonomic_nervous2.20065989
22MP0003787_abnormal_imprinting2.12632214
23MP0002210_abnormal_sex_determination2.11710080
24MP0005551_abnormal_eye_electrophysiolog2.06211158
25MP0002938_white_spotting2.01465119
26MP0000566_synostosis1.96794221
27MP0005389_reproductive_system_phenotype1.96135616
28MP0001145_abnormal_male_reproductive1.82136943
29MP0001188_hyperpigmentation1.82041553
30MP0001929_abnormal_gametogenesis1.81776340
31MP0006292_abnormal_olfactory_placode1.80740012
32MP0002735_abnormal_chemical_nociception1.79240092
33MP0003315_abnormal_perineum_morphology1.76708138
34MP0001984_abnormal_olfaction1.74415845
35MP0000631_abnormal_neuroendocrine_gland1.72658173
36MP0002234_abnormal_pharynx_morphology1.70020992
37MP0000427_abnormal_hair_cycle1.69805131
38MP0004133_heterotaxia1.65520275
39MP0001730_embryonic_growth_arrest1.65370052
40MP0001986_abnormal_taste_sensitivity1.62317386
41MP0009379_abnormal_foot_pigmentation1.61149724
42MP0000653_abnormal_sex_gland1.58605721
43MP0009046_muscle_twitch1.57814092
44MP0000350_abnormal_cell_proliferation1.54433130
45MP0002572_abnormal_emotion/affect_behav1.49014598
46MP0009745_abnormal_behavioral_response1.47482978
47MP0001485_abnormal_pinna_reflex1.46851904
48MP0002557_abnormal_social/conspecific_i1.46277244
49MP0001919_abnormal_reproductive_system1.45540473
50MP0002638_abnormal_pupillary_reflex1.45199585
51MP0002277_abnormal_respiratory_mucosa1.43332295
52MP0004885_abnormal_endolymph1.42568984
53MP0003123_paternal_imprinting1.40576903
54MP0003698_abnormal_male_reproductive1.39803116
55MP0005646_abnormal_pituitary_gland1.39340502
56MP0003121_genomic_imprinting1.38505563
57MP0005499_abnormal_olfactory_system1.36046835
58MP0005394_taste/olfaction_phenotype1.36046835
59MP0001853_heart_inflammation1.35608515
60MP0008995_early_reproductive_senescence1.35550643
61MP0005253_abnormal_eye_physiology1.35234288
62MP0008872_abnormal_physiological_respon1.34945568
63MP0004145_abnormal_muscle_electrophysio1.33533884
64MP0008260_abnormal_autophagy1.33496513
65MP0002272_abnormal_nervous_system1.33059085
66MP0005410_abnormal_fertilization1.31023593
67MP0000313_abnormal_cell_death1.30909614
68MP0002734_abnormal_mechanical_nocicepti1.28106099
69MP0001486_abnormal_startle_reflex1.27552804
70MP0000613_abnormal_salivary_gland1.27113274
71MP0000955_abnormal_spinal_cord1.23998573
72MP0002067_abnormal_sensory_capabilities1.23905091
73MP0010030_abnormal_orbit_morphology1.22980370
74MP0002752_abnormal_somatic_nervous1.22135449
75MP0001672_abnormal_embryogenesis/_devel1.20728359
76MP0005380_embryogenesis_phenotype1.20728359
77MP0003283_abnormal_digestive_organ1.20326798
78MP0005386_behavior/neurological_phenoty1.20217459
79MP0004924_abnormal_behavior1.20217459
80MP0002085_abnormal_embryonic_tissue1.20199903
81MP0002184_abnormal_innervation1.19058571
82MP0000026_abnormal_inner_ear1.16885333
83MP0003635_abnormal_synaptic_transmissio1.16811409
84MP0004043_abnormal_pH_regulation1.16343704
85MP0001970_abnormal_pain_threshold1.16257038
86MP0004742_abnormal_vestibular_system1.15808994
87MP0003878_abnormal_ear_physiology1.15672368
88MP0005377_hearing/vestibular/ear_phenot1.15672368
89MP0005195_abnormal_posterior_eye1.14319617
90MP0005395_other_phenotype1.14220653
91MP0001697_abnormal_embryo_size1.12359873
92MP0003646_muscle_fatigue1.11495155
93MP0000516_abnormal_urinary_system1.11472030
94MP0005367_renal/urinary_system_phenotyp1.11472030
95MP0005645_abnormal_hypothalamus_physiol1.10261445
96MP0002063_abnormal_learning/memory/cond1.09783308
97MP0004381_abnormal_hair_follicle1.09704541
98MP0003861_abnormal_nervous_system1.09232231
99MP0002928_abnormal_bile_duct1.09084478
100MP0002882_abnormal_neuron_morphology1.08417643
101MP0002876_abnormal_thyroid_physiology1.07982999
102MP0003806_abnormal_nucleotide_metabolis1.07483202
103MP0002080_prenatal_lethality1.07238588
104MP0002233_abnormal_nose_morphology1.06455005
105MP0001119_abnormal_female_reproductive1.05799905
106MP0003890_abnormal_embryonic-extraembry1.03285386
107MP0005409_darkened_coat_color1.02069821
108MP0000538_abnormal_urinary_bladder1.01545104
109MP0009053_abnormal_anal_canal1.00163371
110MP0002102_abnormal_ear_morphology0.98834351
111MP0004859_abnormal_synaptic_plasticity0.98827340
112MP0005187_abnormal_penis_morphology0.98796761
113MP0002733_abnormal_thermal_nociception0.98271134
114MP0006035_abnormal_mitochondrial_morpho0.97435089
115MP0005075_abnormal_melanosome_morpholog0.96274730
116MP0000647_abnormal_sebaceous_gland0.95712633
117MP0002152_abnormal_brain_morphology0.95553702
118MP0003122_maternal_imprinting0.94764327
119MP0005391_vision/eye_phenotype0.94485942
120MP0002282_abnormal_trachea_morphology0.94078200
121MP0002064_seizures0.93648413
122MP0001293_anophthalmia0.93567320
123MP0004270_analgesia0.92914938
124MP0003937_abnormal_limbs/digits/tail_de0.91843069
125MP0003186_abnormal_redox_activity0.91603356
126MP0003195_calcinosis0.91148827
127MP0003984_embryonic_growth_retardation0.90989670
128MP0003136_yellow_coat_color0.89646813
129MP0002111_abnormal_tail_morphology0.89591138
130MP0000383_abnormal_hair_follicle0.89208924
131MP0002019_abnormal_tumor_incidence0.87884945
132MP0002088_abnormal_embryonic_growth/wei0.87420892
133MP0002161_abnormal_fertility/fecundity0.87070197
134MP0001286_abnormal_eye_development0.87034546
135MP0005670_abnormal_white_adipose0.86675551
136MP0001501_abnormal_sleep_pattern0.86500988
137MP0003567_abnormal_fetal_cardiomyocyte0.85880324
138MP0003936_abnormal_reproductive_system0.85603780
139MP0003119_abnormal_digestive_system0.85512862
140MP0003942_abnormal_urinary_system0.85254897
141MP0005423_abnormal_somatic_nervous0.85208319
142MP0003938_abnormal_ear_development0.85036634
143MP0009250_abnormal_appendicular_skeleto0.83949880
144MP0001963_abnormal_hearing_physiology0.82501526
145MP0005174_abnormal_tail_pigmentation0.81870759
146MP0005171_absent_coat_pigmentation0.81706276
147MP0002751_abnormal_autonomic_nervous0.81404147
148MP0002132_abnormal_respiratory_system0.79434389
149MP0002116_abnormal_craniofacial_bone0.79274278
150MP0000049_abnormal_middle_ear0.77032339
151MP0005384_cellular_phenotype0.76978053
152MP0010352_gastrointestinal_tract_polyps0.75868047
153MP0000358_abnormal_cell_content/0.75785378
154MP0000490_abnormal_crypts_of0.75739954
155MP0001727_abnormal_embryo_implantation0.74645441
156MP0002653_abnormal_ependyma_morphology0.71769358
157MP0000015_abnormal_ear_pigmentation0.71120609
158MP0005621_abnormal_cell_physiology0.70849520
159MP0001186_pigmentation_phenotype0.70229695
160MP0000678_abnormal_parathyroid_gland0.70055059
161MP0000762_abnormal_tongue_morphology0.69462807
162MP0002084_abnormal_developmental_patter0.69382306
163MP0004142_abnormal_muscle_tone0.68714579
164MP0000462_abnormal_digestive_system0.68703803
165MP0003699_abnormal_female_reproductive0.64727611
166MP0008789_abnormal_olfactory_epithelium0.62508440
167MP0000703_abnormal_thymus_morphology0.61703738
168MP0004197_abnormal_fetal_growth/weight/0.61516571
169MP0001542_abnormal_bone_strength0.59428599
170MP0002269_muscular_atrophy0.59335681
171MP0003755_abnormal_palate_morphology0.59328648
172MP0002075_abnormal_coat/hair_pigmentati0.58029694
173MP0009672_abnormal_birth_weight0.56004786
174MP0006072_abnormal_retinal_apoptosis0.55758012
175MP0009333_abnormal_splenocyte_physiolog0.55108817

Predicted human phenotypes

RankGene SetZ-score
1Progressive external ophthalmoplegia (HP:0000590)6.46059270
2Breast hypoplasia (HP:0003187)5.69683155
3Birth length less than 3rd percentile (HP:0003561)5.13731982
4Muscle abnormality related to mitochondrial dysfunction (HP:0003800)4.70568343
5Molar tooth sign on MRI (HP:0002419)4.34840973
6Abnormality of midbrain morphology (HP:0002418)4.34840973
7True hermaphroditism (HP:0010459)4.13204124
8Cerebral hypomyelination (HP:0006808)4.11183469
9Chromosomal breakage induced by crosslinking agents (HP:0003221)4.07271557
10Nephronophthisis (HP:0000090)3.96702412
11Progressive muscle weakness (HP:0003323)3.89183779
12Chromsome breakage (HP:0040012)3.84546584
13Carpal bone hypoplasia (HP:0001498)3.81848614
14Hyperventilation (HP:0002883)3.68863627
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.51649021
16Medial flaring of the eyebrow (HP:0010747)3.37971114
17Abnormality of the renal medulla (HP:0100957)3.37080138
18Duplicated collecting system (HP:0000081)3.35385079
19External ophthalmoplegia (HP:0000544)3.33321556
20Proximal tubulopathy (HP:0000114)3.30113130
21Meckel diverticulum (HP:0002245)3.25146173
22Chronic hepatic failure (HP:0100626)3.23177898
23Rough bone trabeculation (HP:0100670)3.21226657
24Aplasia/Hypoplasia of the earlobes (HP:0009906)3.17734979
25Absent radius (HP:0003974)3.16637118
26Reticulocytopenia (HP:0001896)3.16296772
27Stomach cancer (HP:0012126)3.11414364
28Gait imbalance (HP:0002141)3.09615936
29Patellar aplasia (HP:0006443)3.08807673
30Cystic liver disease (HP:0006706)3.04675465
31Aplasia/Hypoplasia of the patella (HP:0006498)3.04522342
32Abnormality of the ileum (HP:0001549)3.02979365
33Microvesicular hepatic steatosis (HP:0001414)2.99897293
34Abnormal ciliary motility (HP:0012262)2.98774906
35Absent forearm bone (HP:0003953)2.98217137
36Aplasia involving forearm bones (HP:0009822)2.98217137
37Granulocytopenia (HP:0001913)2.97136861
38Abnormality of the renal collecting system (HP:0004742)2.95156741
39Abnormality of the preputium (HP:0100587)2.94515367
40Type II lissencephaly (HP:0007260)2.86339941
41Congenital primary aphakia (HP:0007707)2.82972970
42Congenital stationary night blindness (HP:0007642)2.79439018
43Abnormality of the renal cortex (HP:0011035)2.77415500
44Aplasia/Hypoplasia involving the musculature (HP:0001460)2.76987071
45Sclerocornea (HP:0000647)2.74043961
46Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.73539859
47Abnormal respiratory motile cilium morphology (HP:0005938)2.72963993
48Abnormal respiratory epithelium morphology (HP:0012253)2.72963993
49Abnormal respiratory motile cilium physiology (HP:0012261)2.72698590
50Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.71970030
51Anencephaly (HP:0002323)2.71472494
52Lissencephaly (HP:0001339)2.70559078
53Abnormality of chromosome stability (HP:0003220)2.68916472
54Genetic anticipation (HP:0003743)2.67123174
55Macrocytic anemia (HP:0001972)2.66567727
56Dynein arm defect of respiratory motile cilia (HP:0012255)2.66227528
57Absent/shortened dynein arms (HP:0200106)2.66227528
58Oral leukoplakia (HP:0002745)2.65330508
59Aplasia/Hypoplasia of the uvula (HP:0010293)2.64391962
60Nephrogenic diabetes insipidus (HP:0009806)2.63762785
61Abnormal spermatogenesis (HP:0008669)2.63435755
62Tubular atrophy (HP:0000092)2.62575375
63Horseshoe kidney (HP:0000085)2.60916119
64Impulsivity (HP:0100710)2.60265506
65Aplasia/Hypoplasia of the tongue (HP:0010295)2.59458561
66Aplasia/hypoplasia of the uterus (HP:0008684)2.59190602
67Neoplasm of the adrenal cortex (HP:0100641)2.55657743
68Abnormal trabecular bone morphology (HP:0100671)2.55150348
69Absent thumb (HP:0009777)2.50786575
70Genital tract atresia (HP:0001827)2.49280584
71Increased serum lactate (HP:0002151)2.46573576
72Occipital encephalocele (HP:0002085)2.45037343
73Secondary amenorrhea (HP:0000869)2.44543839
74Vaginal atresia (HP:0000148)2.43124159
75Postaxial foot polydactyly (HP:0001830)2.42971267
76Broad-based gait (HP:0002136)2.42800160
77Supernumerary spleens (HP:0009799)2.40890936
78Neoplasm of the pancreas (HP:0002894)2.35460643
79Cerebellar dysplasia (HP:0007033)2.33829747
80Premature graying of hair (HP:0002216)2.32286956
81Bone marrow hypocellularity (HP:0005528)2.32203721
82Type 2 muscle fiber atrophy (HP:0003554)2.31554057
83Congenital hepatic fibrosis (HP:0002612)2.30068956
84Pendular nystagmus (HP:0012043)2.29285297
85Triphalangeal thumb (HP:0001199)2.28383482
86CNS hypomyelination (HP:0003429)2.28234134
87Exercise intolerance (HP:0003546)2.26278246
88Trismus (HP:0000211)2.25301576
89Retinal dysplasia (HP:0007973)2.24398474
90Premature ovarian failure (HP:0008209)2.23732516
91Glucose intolerance (HP:0000833)2.23475188
92Aplasia/Hypoplasia of the sacrum (HP:0008517)2.22722148
93Pancreatic cysts (HP:0001737)2.20590905
94Aplasia/Hypoplasia of the tibia (HP:0005772)2.20008694
95Progressive cerebellar ataxia (HP:0002073)2.19744478
96Small intestinal stenosis (HP:0012848)2.19059131
97Duodenal stenosis (HP:0100867)2.19059131
98Absent speech (HP:0001344)2.19018041
99Rhinitis (HP:0012384)2.18271112
100Postaxial hand polydactyly (HP:0001162)2.17375462
101Pachygyria (HP:0001302)2.16023595
102Facial cleft (HP:0002006)2.15625705
103Preaxial hand polydactyly (HP:0001177)2.14800288
104Poor coordination (HP:0002370)2.14409351
105Breast aplasia (HP:0100783)2.14290171
106Keratoconus (HP:0000563)2.14245005
107Increased corneal curvature (HP:0100692)2.14245005
108Cleft eyelid (HP:0000625)2.13848936
109Inability to walk (HP:0002540)2.13796047
110Ureteral duplication (HP:0000073)2.13525844
111Attenuation of retinal blood vessels (HP:0007843)2.12736775
112Aplasia/Hypoplasia of the breasts (HP:0010311)2.11772711
113Narrow forehead (HP:0000341)2.11360106
114Megaloblastic anemia (HP:0001889)2.09985650
115Ectopic kidney (HP:0000086)2.09971229
116Azoospermia (HP:0000027)2.09647032
117Abnormality of cells of the erythroid lineage (HP:0012130)2.09060225
118Anophthalmia (HP:0000528)2.06919051
119Protruding tongue (HP:0010808)2.06742606
1203-Methylglutaconic aciduria (HP:0003535)2.05694957
121Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.05339117
122Decreased activity of mitochondrial respiratory chain (HP:0008972)2.05339117
123Abnormal rod and cone electroretinograms (HP:0008323)2.04641373
124Microretrognathia (HP:0000308)2.04371839
125Absent rod-and cone-mediated responses on ERG (HP:0007688)2.03666891
126Hepatocellular necrosis (HP:0001404)2.02955743
127Abnormal lung lobation (HP:0002101)2.02514539
128Optic nerve hypoplasia (HP:0000609)2.02031193
129Hemiparesis (HP:0001269)2.01760308
130Abnormal number of erythroid precursors (HP:0012131)2.01361954
131Muscle fiber atrophy (HP:0100295)1.98456195
132Gaze-evoked nystagmus (HP:0000640)1.98442521
133Dandy-Walker malformation (HP:0001305)1.97151972
134Polydipsia (HP:0001959)1.97048688
135Abnormal drinking behavior (HP:0030082)1.97048688
136Large for gestational age (HP:0001520)1.95462163
137Abnormality of the labia minora (HP:0012880)1.95109899
138Abnormality of the anterior horn cell (HP:0006802)1.94397325
139Degeneration of anterior horn cells (HP:0002398)1.94397325
140Bony spicule pigmentary retinopathy (HP:0007737)1.94386675
141Type I transferrin isoform profile (HP:0003642)1.94085850
142Glioma (HP:0009733)1.93010279
143Acute necrotizing encephalopathy (HP:0006965)1.92033920
144Highly arched eyebrow (HP:0002553)1.90958815
145Male pseudohermaphroditism (HP:0000037)1.90813707
146Mitochondrial inheritance (HP:0001427)1.89809653
147Breech presentation (HP:0001623)1.88417908
148Rib fusion (HP:0000902)1.87733140
149Cellular immunodeficiency (HP:0005374)1.87050551
150Acute lymphatic leukemia (HP:0006721)1.86427155
151Furrowed tongue (HP:0000221)1.86364684
152Prominent nasal bridge (HP:0000426)1.85891105
153Testicular atrophy (HP:0000029)1.85647821
154Selective tooth agenesis (HP:0001592)1.85301710
155Oligodactyly (hands) (HP:0001180)1.85289426
156Bile duct proliferation (HP:0001408)1.84737245
157Abnormal biliary tract physiology (HP:0012439)1.84737245
158Hypoplasia of the radius (HP:0002984)1.84575223
159Clubbing of toes (HP:0100760)1.84369375
160Intestinal atresia (HP:0011100)1.83939582
161Prolonged neonatal jaundice (HP:0006579)1.83404837
162Sloping forehead (HP:0000340)1.83006915
163Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.82676645
164Concave nail (HP:0001598)1.81544719
165Drooling (HP:0002307)1.81354393
166Pancreatic fibrosis (HP:0100732)1.80564021
167Aganglionic megacolon (HP:0002251)1.80443847
168Eosinophilia (HP:0001880)1.79854635
169Hepatic necrosis (HP:0002605)1.79709793
170Tracheoesophageal fistula (HP:0002575)1.79676664
171Unsteady gait (HP:0002317)1.79595778
172Fetal akinesia sequence (HP:0001989)1.79402490
173Abnormality of the duodenum (HP:0002246)1.77921090
174Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.77001146
175Colon cancer (HP:0003003)1.76869400
176Short foot (HP:0001773)1.75636057
177Aplasia/Hypoplasia of the lens (HP:0008063)1.74604283
178Hypoplasia of the pons (HP:0012110)1.74349336
179Astigmatism (HP:0000483)1.73423815
180Chorioretinal atrophy (HP:0000533)1.71753286
181Progressive inability to walk (HP:0002505)1.69118531
182Renal cortical cysts (HP:0000803)1.67741608
183Small hand (HP:0200055)1.66135888
184Tubulointerstitial nephritis (HP:0001970)1.65413589
185Broad foot (HP:0001769)1.65286545
186Abnormality of the pons (HP:0007361)1.63497702
187Multicystic kidney dysplasia (HP:0000003)1.63353683
188Specific learning disability (HP:0001328)1.62413429
189Abolished electroretinogram (ERG) (HP:0000550)1.61235781
190Cutaneous finger syndactyly (HP:0010554)1.60821844
191Bilateral microphthalmos (HP:0007633)1.60709958
192Renal hypoplasia (HP:0000089)1.59195873
193Severe muscular hypotonia (HP:0006829)1.59187777

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK36.34186674
2BUB15.16864372
3PLK45.04792412
4FRK4.99753598
5ZAK3.78202856
6MARK13.68826874
7STK163.68040640
8CASK3.45152243
9WEE13.12234943
10IRAK22.90634961
11IRAK42.82374855
12EIF2AK12.76029206
13WNK32.72905978
14NUAK12.59325551
15IRAK12.57243944
16TTK2.54168732
17BMPR1B2.38458383
18MAPK132.37874073
19MAP3K42.28917645
20SRPK12.22369644
21ADRBK22.07154730
22TESK22.01024079
23MAP4K21.99714028
24EIF2AK31.98293915
25PNCK1.96019170
26EPHA21.90795181
27CDC71.90645619
28EPHB21.86138709
29INSRR1.79452890
30LATS11.78793399
31TSSK61.77374943
32WNK41.58381158
33PLK11.54756256
34PLK31.50865157
35MAP2K71.48552649
36TLK11.45247519
37TRIM281.42335217
38DYRK31.34701228
39STK391.26539787
40BRSK21.26035119
41VRK11.25489806
42PBK1.23244164
43SIK21.14511950
44ATR1.13247394
45PAK31.11196660
46CHEK21.08374033
47PRKCI1.07308801
48CSNK1G21.05790733
49BRSK11.02645757
50AURKA1.01987226
51CSNK1A1L1.01708273
52OXSR11.01445189
53ADRBK11.00764436
54NEK20.97590691
55PHKG20.96128973
56PHKG10.96128973
57CSNK1G10.95408430
58NME10.95058601
59TESK10.94893136
60CSNK1G30.93331893
61STK38L0.93228946
62MKNK10.91795257
63AKT30.88996113
64AURKB0.88243837
65EIF2AK20.87659719
66RPS6KB20.87649530
67TAOK30.87638477
68ACVR1B0.87269313
69MKNK20.86520396
70VRK20.86191496
71PRKCE0.85282864
72PAK40.79571407
73CDC42BPA0.78046813
74NEK10.75974281
75NTRK20.75389844
76CAMK1G0.73688876
77PKN10.72785498
78CHEK10.72777879
79MUSK0.70771132
80DYRK20.69919483
81KDR0.67934173
82STK30.63393110
83CDK70.63287937
84BRAF0.63139011
85NTRK30.62783492
86STK40.58918346
87LATS20.56173948
88MAP3K80.54784370
89ATM0.54773927
90TGFBR10.52765122
91NEK60.52192574
92LIMK10.51537402
93CAMK2A0.50330109
94PAK10.50068110
95ABL20.49036541
96PRKCZ0.49030307
97PTK2B0.47653783
98TIE10.47639531
99FGFR20.47264701
100DYRK1A0.45490925
101CCNB10.44467038
102BRD40.44418135
103PRKAA10.43204316
104CSNK2A10.42721675
105PINK10.42499813
106PASK0.41665129
107CDK20.41526215
108CAMK2B0.39881143
109CAMK1D0.39318813
110CSNK1D0.39005833
111ERBB20.38805504
112CDK10.38486233
113STK110.38026907
114CSNK2A20.37157768
115BLK0.36532204
116TNIK0.35677997
117TAF10.35662572
118CAMK2G0.35560922
119MAPKAPK30.35199432
120MINK10.35112877
121RPS6KA50.34106070
122CAMK2D0.33746236
123PRKACA0.33574046
124NME20.33452526
125MAPK70.33237680
126ERBB30.32382527
127CSNK1A10.31572673
128CSNK1E0.31542568
129DAPK20.31391172
130EPHA40.31284254
131CAMKK20.31149687
132MAP3K110.30025873
133PIM20.29534380
134CAMK10.29385256
135CDK50.27243113
136STK380.26417440
137PLK20.23740493
138MELK0.22093568
139PRKDC0.20050391
140CLK10.19004422
141GRK10.16568724
142MAPK150.16262412
143BCKDK0.15639377
144ALK0.15565534
145MAPK40.13908347
146RPS6KA40.13775645
147NLK0.12768491
148STK100.10942370
149PDK20.09811588
150BCR0.07631087
151GSK3B0.07451034
152CDK30.06620724
153STK240.05228721
154MAPK80.05004687
155MAPK90.04635814
156PRKCG0.04464716
157MAPK100.04370729
158ARAF0.04124100

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.52248309
2RNA polymerase_Homo sapiens_hsa030204.40136709
3DNA replication_Homo sapiens_hsa030304.31496753
4Mismatch repair_Homo sapiens_hsa034303.75553720
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.74175321
6Ribosome_Homo sapiens_hsa030103.47582839
7Fanconi anemia pathway_Homo sapiens_hsa034603.25162853
8Spliceosome_Homo sapiens_hsa030403.07725663
9Homologous recombination_Homo sapiens_hsa034403.01222132
10Pyrimidine metabolism_Homo sapiens_hsa002402.97275318
11RNA transport_Homo sapiens_hsa030132.67550081
12Nucleotide excision repair_Homo sapiens_hsa034202.61032811
13Nicotine addiction_Homo sapiens_hsa050332.59348216
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.33957129
15Base excision repair_Homo sapiens_hsa034102.33910018
16Cell cycle_Homo sapiens_hsa041102.30264832
17Basal transcription factors_Homo sapiens_hsa030222.26071756
18One carbon pool by folate_Homo sapiens_hsa006702.23097086
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.06349461
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.03651904
21Butanoate metabolism_Homo sapiens_hsa006502.00223752
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.91837675
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.86033703
24Purine metabolism_Homo sapiens_hsa002301.80632124
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.76585444
26RNA degradation_Homo sapiens_hsa030181.72288788
27Oxidative phosphorylation_Homo sapiens_hsa001901.72122843
28p53 signaling pathway_Homo sapiens_hsa041151.63580878
29Huntingtons disease_Homo sapiens_hsa050161.63258842
30Non-homologous end-joining_Homo sapiens_hsa034501.63172712
31Nitrogen metabolism_Homo sapiens_hsa009101.58334705
32Parkinsons disease_Homo sapiens_hsa050121.51330115
33Taste transduction_Homo sapiens_hsa047421.47421641
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.41387782
35Vitamin B6 metabolism_Homo sapiens_hsa007501.41382081
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.37590472
37Tryptophan metabolism_Homo sapiens_hsa003801.35640256
38Axon guidance_Homo sapiens_hsa043601.34881221
39Epstein-Barr virus infection_Homo sapiens_hsa051691.34559823
40Morphine addiction_Homo sapiens_hsa050321.33956483
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.32858877
42Glutamatergic synapse_Homo sapiens_hsa047241.32134376
43Olfactory transduction_Homo sapiens_hsa047401.25996916
44Glutathione metabolism_Homo sapiens_hsa004801.21720672
45mRNA surveillance pathway_Homo sapiens_hsa030151.21052755
46Circadian entrainment_Homo sapiens_hsa047131.18586742
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.17413968
48Maturity onset diabetes of the young_Homo sapiens_hsa049501.14364036
49Cocaine addiction_Homo sapiens_hsa050301.07200081
50ABC transporters_Homo sapiens_hsa020101.06496713
51Protein export_Homo sapiens_hsa030601.06490525
52Insulin secretion_Homo sapiens_hsa049111.05599084
53GABAergic synapse_Homo sapiens_hsa047270.97984121
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.97414907
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97371492
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96459299
57Dopaminergic synapse_Homo sapiens_hsa047280.95519425
58Pentose phosphate pathway_Homo sapiens_hsa000300.95122078
59Propanoate metabolism_Homo sapiens_hsa006400.95093816
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.95051002
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93576559
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.93170265
63Folate biosynthesis_Homo sapiens_hsa007900.91457548
64Lysine degradation_Homo sapiens_hsa003100.90904192
65Serotonergic synapse_Homo sapiens_hsa047260.90727562
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.87717383
67Oocyte meiosis_Homo sapiens_hsa041140.86483465
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86061447
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.84529768
70Glycerolipid metabolism_Homo sapiens_hsa005610.82332438
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.81536126
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80950542
73Alzheimers disease_Homo sapiens_hsa050100.80494887
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80187898
75Chemical carcinogenesis_Homo sapiens_hsa052040.79621771
76Calcium signaling pathway_Homo sapiens_hsa040200.78627820
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74840691
78Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.74516606
79Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74163642
80Circadian rhythm_Homo sapiens_hsa047100.74135366
81Arachidonic acid metabolism_Homo sapiens_hsa005900.73886376
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71685187
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69706033
84Amphetamine addiction_Homo sapiens_hsa050310.68005271
85Regulation of autophagy_Homo sapiens_hsa041400.67591722
86Phototransduction_Homo sapiens_hsa047440.66336955
87Cholinergic synapse_Homo sapiens_hsa047250.65724232
88Ovarian steroidogenesis_Homo sapiens_hsa049130.65534224
89Peroxisome_Homo sapiens_hsa041460.65278885
90Salivary secretion_Homo sapiens_hsa049700.64293921
91Dorso-ventral axis formation_Homo sapiens_hsa043200.63670475
92Wnt signaling pathway_Homo sapiens_hsa043100.63540266
93Metabolic pathways_Homo sapiens_hsa011000.60141610
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59305939
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59188551
96Caffeine metabolism_Homo sapiens_hsa002320.58967951
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.58502076
98Systemic lupus erythematosus_Homo sapiens_hsa053220.57599982
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.57224145
100cAMP signaling pathway_Homo sapiens_hsa040240.53928406
101Primary bile acid biosynthesis_Homo sapiens_hsa001200.53438279
102Arginine and proline metabolism_Homo sapiens_hsa003300.53237567
103Sphingolipid metabolism_Homo sapiens_hsa006000.52362841
104Long-term depression_Homo sapiens_hsa047300.51725491
105Linoleic acid metabolism_Homo sapiens_hsa005910.51315993
106Other glycan degradation_Homo sapiens_hsa005110.49937083
107Biosynthesis of amino acids_Homo sapiens_hsa012300.49574485
108Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46974207
109Viral carcinogenesis_Homo sapiens_hsa052030.45562419
110Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42306217
111Oxytocin signaling pathway_Homo sapiens_hsa049210.41601237
112Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40408758
113Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37717190
114Fructose and mannose metabolism_Homo sapiens_hsa000510.37551679
115HTLV-I infection_Homo sapiens_hsa051660.36621647
116Selenocompound metabolism_Homo sapiens_hsa004500.33806917
117Herpes simplex infection_Homo sapiens_hsa051680.33538270
118SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29780398
119alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28514765
120Cardiac muscle contraction_Homo sapiens_hsa042600.27122540
121Ether lipid metabolism_Homo sapiens_hsa005650.25451594
122Renin-angiotensin system_Homo sapiens_hsa046140.23562926
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.23022192
124Carbon metabolism_Homo sapiens_hsa012000.22236377
125Hedgehog signaling pathway_Homo sapiens_hsa043400.20311833
126Sulfur relay system_Homo sapiens_hsa041220.17023907
127NF-kappa B signaling pathway_Homo sapiens_hsa040640.15210374
128Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.14775561
129Collecting duct acid secretion_Homo sapiens_hsa049660.14249495
130Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.13719729
131Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.13604735
132Phenylalanine metabolism_Homo sapiens_hsa003600.13165608
133Antigen processing and presentation_Homo sapiens_hsa046120.13140622
134Hippo signaling pathway_Homo sapiens_hsa043900.12754750
135Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.11820620
136Vitamin digestion and absorption_Homo sapiens_hsa049770.11085234
137Basal cell carcinoma_Homo sapiens_hsa052170.10720957
138beta-Alanine metabolism_Homo sapiens_hsa004100.10312082
139Tyrosine metabolism_Homo sapiens_hsa003500.09539171
140Steroid biosynthesis_Homo sapiens_hsa001000.09337324
141Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.08812494
142Alcoholism_Homo sapiens_hsa050340.06866935
143Tight junction_Homo sapiens_hsa045300.06469069
144Retinol metabolism_Homo sapiens_hsa008300.06074291
145Galactose metabolism_Homo sapiens_hsa000520.06052317
146Shigellosis_Homo sapiens_hsa051310.04039937
147Autoimmune thyroid disease_Homo sapiens_hsa053200.03403503
148Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.02248702
149Vibrio cholerae infection_Homo sapiens_hsa051100.02013084
150N-Glycan biosynthesis_Homo sapiens_hsa005100.01102223
151TGF-beta signaling pathway_Homo sapiens_hsa043500.00539619
152Primary immunodeficiency_Homo sapiens_hsa05340-0.0187978
153MicroRNAs in cancer_Homo sapiens_hsa05206-0.0032102

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