CEP97

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)8.21565236
2ribosome assembly (GO:0042255)6.63932354
3telomere maintenance via semi-conservative replication (GO:0032201)6.47931444
4DNA strand elongation involved in DNA replication (GO:0006271)5.87492147
5DNA strand elongation (GO:0022616)5.57534236
6DNA replication initiation (GO:0006270)5.48932864
7telomere maintenance via recombination (GO:0000722)5.29195928
8pyrimidine nucleobase catabolic process (GO:0006208)4.81728268
9negative regulation of transcription by competitive promoter binding (GO:0010944)4.81255806
10negative regulation of myotube differentiation (GO:0010832)4.81227646
11viral transcription (GO:0019083)4.76290953
12ribosomal small subunit assembly (GO:0000028)4.73333862
13translational termination (GO:0006415)4.61094987
14mitotic recombination (GO:0006312)4.55969720
15GDP-mannose metabolic process (GO:0019673)4.55538753
16telomere maintenance via telomere lengthening (GO:0010833)4.49010223
17SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.35446061
18deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.35229484
19ribosomal small subunit biogenesis (GO:0042274)4.31638678
20cotranslational protein targeting to membrane (GO:0006613)4.25502704
21protein targeting to ER (GO:0045047)4.21607041
22regulation of cellular respiration (GO:0043457)4.20811102
23translational elongation (GO:0006414)4.11260243
24respiratory chain complex IV assembly (GO:0008535)4.08280201
25presynaptic membrane assembly (GO:0097105)4.06213631
26protein localization to endoplasmic reticulum (GO:0070972)4.04600902
27pseudouridine synthesis (GO:0001522)3.99013414
28establishment of protein localization to endoplasmic reticulum (GO:0072599)3.98912153
29negative regulation of granulocyte differentiation (GO:0030853)3.95891463
30presynaptic membrane organization (GO:0097090)3.86811008
31nucleobase catabolic process (GO:0046113)3.84269715
32epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.83156246
33nucleotide-excision repair, DNA gap filling (GO:0006297)3.81120901
34translational initiation (GO:0006413)3.74470261
35maturation of SSU-rRNA (GO:0030490)3.71558346
36pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.69957276
37ribosomal large subunit biogenesis (GO:0042273)3.59408245
38regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.55455053
39disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.52600928
40killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.52600928
41DNA replication checkpoint (GO:0000076)3.52453926
42neural tube formation (GO:0001841)3.51465317
43nonmotile primary cilium assembly (GO:0035058)3.51419360
44cellular protein complex disassembly (GO:0043624)3.50635771
45regulation of DNA endoreduplication (GO:0032875)3.49591330
46mannosylation (GO:0097502)3.49039795
47viral life cycle (GO:0019058)3.48834647
48microtubule depolymerization (GO:0007019)3.46735767
49ribonucleoprotein complex biogenesis (GO:0022613)3.46525985
50myeloid leukocyte mediated immunity (GO:0002444)3.43491246
51centriole replication (GO:0007099)3.42459859
52nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.42374450
53epithelial cilium movement (GO:0003351)3.37132214
54proteasome assembly (GO:0043248)3.36420135
55regulation of apoptotic process involved in morphogenesis (GO:1902337)3.36203871
56retinal cone cell development (GO:0046549)3.33929833
57translation (GO:0006412)3.30738324
58dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.27234031
59pyrimidine nucleotide catabolic process (GO:0006244)3.25694690
60DNA unwinding involved in DNA replication (GO:0006268)3.25596518
61nucleobase biosynthetic process (GO:0046112)3.25427745
62establishment of integrated proviral latency (GO:0075713)3.21883921
63C-terminal protein lipidation (GO:0006501)3.21847943
64neutrophil mediated immunity (GO:0002446)3.17589180
65ribosome biogenesis (GO:0042254)3.16208233
66positive regulation of cellular amine metabolic process (GO:0033240)3.15911083
67replication fork processing (GO:0031297)3.14752265
68postsynaptic membrane organization (GO:0001941)3.14711605
69positive regulation of protein export from nucleus (GO:0046827)3.12991258
70cilium movement (GO:0003341)3.09188018
71microtubule anchoring (GO:0034453)3.09167879
72intraciliary transport (GO:0042073)3.06453126
73resolution of meiotic recombination intermediates (GO:0000712)3.06283227
74protein complex disassembly (GO:0043241)3.03154165
75regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.02835390
76rRNA processing (GO:0006364)3.02367278
77central nervous system projection neuron axonogenesis (GO:0021952)3.00963888
78deoxyribonucleotide biosynthetic process (GO:0009263)3.00797394
79exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.00392096
80modulation of growth of symbiont involved in interaction with host (GO:0044144)2.99528026
81regulation of growth of symbiont in host (GO:0044126)2.99528026
82negative regulation of growth of symbiont in host (GO:0044130)2.99528026
83negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.99528026
84behavioral response to nicotine (GO:0035095)2.98481636
85L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.97305343
86pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.96979207
87limb bud formation (GO:0060174)2.95181466
88axonal fasciculation (GO:0007413)2.94399212
89retinal ganglion cell axon guidance (GO:0031290)2.93339861
90nucleobase-containing small molecule interconversion (GO:0015949)2.92271612
91heme biosynthetic process (GO:0006783)2.92090045
92cytochrome complex assembly (GO:0017004)2.91349750
93macromolecular complex disassembly (GO:0032984)2.91319812
94purine nucleobase biosynthetic process (GO:0009113)2.91217133
95rRNA metabolic process (GO:0016072)2.89794305
96olfactory bulb development (GO:0021772)2.88213014
97chromatin remodeling at centromere (GO:0031055)2.87879029
98regulation of cilium movement (GO:0003352)2.87017726
99transcription-coupled nucleotide-excision repair (GO:0006283)2.86787743
100spliceosomal snRNP assembly (GO:0000387)2.86604713
101CENP-A containing nucleosome assembly (GO:0034080)2.85876127
102negative regulation of RNA splicing (GO:0033119)2.84917283
103neuron cell-cell adhesion (GO:0007158)2.84449510
104GPI anchor biosynthetic process (GO:0006506)2.84290944
105telomere organization (GO:0032200)2.84013811
106telomere maintenance (GO:0000723)2.83365559
107IMP metabolic process (GO:0046040)2.83345898
108cilium organization (GO:0044782)2.81609489
109negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.81114349
110negative regulation of cytosolic calcium ion concentration (GO:0051481)2.80835594
111deoxyribose phosphate biosynthetic process (GO:0046385)2.80769803
1122-deoxyribonucleotide biosynthetic process (GO:0009265)2.80769803
113regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.80733142
114microtubule polymerization or depolymerization (GO:0031109)2.80550578
115cellular component biogenesis (GO:0044085)2.79155619
116nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.78306732
117pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.78056677
118cilium assembly (GO:0042384)2.78026937
119regulation of cellular amino acid metabolic process (GO:0006521)2.77820515
120regulation of protein heterodimerization activity (GO:0043497)2.77681013
121intra-S DNA damage checkpoint (GO:0031573)2.77612726
122formation of translation preinitiation complex (GO:0001731)2.77444299
123rRNA modification (GO:0000154)2.77345838
124positive regulation of glycoprotein biosynthetic process (GO:0010560)2.77244923
125sister chromatid segregation (GO:0000819)2.76778720
126neuron recognition (GO:0008038)2.76466887
127deoxyribonucleotide catabolic process (GO:0009264)2.75702077
128generation of neurons (GO:0048699)2.75209851
129C-terminal protein amino acid modification (GO:0018410)2.75198849
130transcription elongation from RNA polymerase III promoter (GO:0006385)2.75130436
131termination of RNA polymerase III transcription (GO:0006386)2.75130436
132cilium or flagellum-dependent cell motility (GO:0001539)2.74947364
133regulation of centriole replication (GO:0046599)2.74868611
134DNA double-strand break processing (GO:0000729)2.74614755
135cilium morphogenesis (GO:0060271)2.73285957
136central nervous system neuron axonogenesis (GO:0021955)2.73284712
137G1/S transition of mitotic cell cycle (GO:0000082)2.72928312
138kinetochore organization (GO:0051383)2.72911236
139protein K11-linked deubiquitination (GO:0035871)2.71930880
140negative regulation of DNA-dependent DNA replication (GO:2000104)2.70670111
141meiotic chromosome segregation (GO:0045132)2.70468369
142cerebral cortex radially oriented cell migration (GO:0021799)2.67386811
143protein polyglutamylation (GO:0018095)2.67067377
144negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.63767818
145negative regulation of translation, ncRNA-mediated (GO:0040033)2.63767818
146regulation of translation, ncRNA-mediated (GO:0045974)2.63767818
147synapsis (GO:0007129)2.63580902
148protein K6-linked ubiquitination (GO:0085020)2.63488681
149mitotic sister chromatid cohesion (GO:0007064)2.63084968
150G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.62107474
151protein localization to synapse (GO:0035418)2.61930806
152righting reflex (GO:0060013)2.59641780
153axoneme assembly (GO:0035082)2.58433146
154transmission of nerve impulse (GO:0019226)2.57128624
155startle response (GO:0001964)2.55118722
156establishment of nucleus localization (GO:0040023)2.54862273
157mitotic sister chromatid segregation (GO:0000070)2.51651514
158maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.51633175
159negative regulation of DNA recombination (GO:0045910)2.50964638
160behavioral response to ethanol (GO:0048149)2.48455177
161protein localization to cilium (GO:0061512)2.46547947
162nucleus localization (GO:0051647)2.45781434
163mechanosensory behavior (GO:0007638)2.44461528
164limb development (GO:0060173)2.44054178
165appendage development (GO:0048736)2.44054178
166microtubule organizing center organization (GO:0031023)2.43106626
167regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.41644860
168photoreceptor cell maintenance (GO:0045494)2.41168795
169retina layer formation (GO:0010842)2.39949969
170recombinational repair (GO:0000725)2.39667690
171detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.38968052
172microtubule bundle formation (GO:0001578)2.38964678
173auditory behavior (GO:0031223)2.38417334
174glutamate receptor signaling pathway (GO:0007215)2.37719818
175kinetochore assembly (GO:0051382)2.37002404
176double-strand break repair via homologous recombination (GO:0000724)2.36924972
177regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.35824347
178sympathetic nervous system development (GO:0048485)2.34921069
179axonemal dynein complex assembly (GO:0070286)2.34908812
180histone exchange (GO:0043486)2.33505731
181cellular component assembly involved in morphogenesis (GO:0010927)2.33128802
182neurotransmitter-gated ion channel clustering (GO:0072578)2.31945949
183reciprocal DNA recombination (GO:0035825)2.31598392
184reciprocal meiotic recombination (GO:0007131)2.31598392
185translesion synthesis (GO:0019985)2.31261384
186response to pheromone (GO:0019236)2.31155198
187atrial cardiac muscle cell action potential (GO:0086014)2.29958512
188ionotropic glutamate receptor signaling pathway (GO:0035235)2.28477766
189hindbrain development (GO:0030902)2.27481706
190centrosome organization (GO:0051297)2.27326957
191interkinetic nuclear migration (GO:0022027)2.26795063
192regulation of centrosome cycle (GO:0046605)2.26272510
193spinal cord motor neuron differentiation (GO:0021522)2.25389560
194forebrain neuron differentiation (GO:0021879)2.24635074
195gamma-aminobutyric acid transport (GO:0015812)2.24505480
196smoothened signaling pathway (GO:0007224)2.24194987
197regulation of centrosome duplication (GO:0010824)2.24001425
198cytoplasmic mRNA processing body assembly (GO:0033962)2.23603181

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.25400230
2EZH2_22144423_ChIP-Seq_EOC_Human5.85960592
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.63699626
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.45175769
5GBX2_23144817_ChIP-Seq_PC3_Human3.40078672
6MYC_18358816_ChIP-ChIP_MESCs_Mouse3.35117057
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.32329704
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.30277452
9SALL1_21062744_ChIP-ChIP_HESCs_Human3.27443755
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.23326280
11GABP_17652178_ChIP-ChIP_JURKAT_Human3.22598850
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.21300470
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.11628681
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.92617652
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.84909003
16* ETS1_20019798_ChIP-Seq_JURKAT_Human2.83548050
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.82356942
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.80266205
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.76855446
20ZNF274_21170338_ChIP-Seq_K562_Hela2.70290070
21E2F4_17652178_ChIP-ChIP_JURKAT_Human2.67162172
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.66408483
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.64971347
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.62451654
25IGF1R_20145208_ChIP-Seq_DFB_Human2.58141659
26TAF15_26573619_Chip-Seq_HEK293_Human2.52456054
27FUS_26573619_Chip-Seq_HEK293_Human2.51666309
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.44033249
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.36707410
30RBPJ_22232070_ChIP-Seq_NCS_Mouse2.33321272
31TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.30114786
32CTBP2_25329375_ChIP-Seq_LNCAP_Human2.28778395
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.28448510
34GATA1_22025678_ChIP-Seq_K562_Human2.26982740
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.26459609
36EWS_26573619_Chip-Seq_HEK293_Human2.25641579
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.22157983
38FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.16131472
39VDR_23849224_ChIP-Seq_CD4+_Human2.15209343
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.14458643
41E2F1_18555785_ChIP-Seq_MESCs_Mouse2.11052483
42VDR_22108803_ChIP-Seq_LS180_Human2.10782852
43P300_19829295_ChIP-Seq_ESCs_Human2.08998675
44RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.08878912
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.04034912
46NELFA_20434984_ChIP-Seq_ESCs_Mouse2.01763881
47* XRN2_22483619_ChIP-Seq_HELA_Human2.01356987
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.00002975
49CREB1_15753290_ChIP-ChIP_HEK293T_Human1.99230117
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.97733945
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.93476079
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.89217931
53ERG_20887958_ChIP-Seq_HPC-7_Mouse1.87787574
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.85877614
55BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.85027398
56SMAD4_21799915_ChIP-Seq_A2780_Human1.84679429
57CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.83461356
58MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.81525177
59NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.80956637
60FOXP3_21729870_ChIP-Seq_TREG_Human1.80150980
61DCP1A_22483619_ChIP-Seq_HELA_Human1.79128239
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.78478436
63MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.78175003
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.77814878
65THAP11_20581084_ChIP-Seq_MESCs_Mouse1.77546228
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.73249842
67SCL_19346495_ChIP-Seq_HPC-7_Human1.71869732
68STAT3_23295773_ChIP-Seq_U87_Human1.71227266
69VDR_21846776_ChIP-Seq_THP-1_Human1.69435104
70MYB_21317192_ChIP-Seq_ERMYB_Mouse1.69102044
71CBX2_27304074_Chip-Seq_ESCs_Mouse1.66895637
72TTF2_22483619_ChIP-Seq_HELA_Human1.66468715
73* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.65561248
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64888235
75GABP_19822575_ChIP-Seq_HepG2_Human1.63665137
76MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.63485268
77FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.59297478
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.57666607
79FLI1_27457419_Chip-Seq_LIVER_Mouse1.57489058
80E2F1_21310950_ChIP-Seq_MCF-7_Human1.56122254
81TOP2B_26459242_ChIP-Seq_MCF-7_Human1.56046461
82MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.55897817
83SMAD3_21741376_ChIP-Seq_EPCs_Human1.54977182
84FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.54815339
85FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.53418186
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.52484330
87* TCF4_23295773_ChIP-Seq_U87_Human1.52372883
88ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.51696824
89ER_23166858_ChIP-Seq_MCF-7_Human1.50670182
90MYCN_18555785_ChIP-Seq_MESCs_Mouse1.50568410
91AR_21572438_ChIP-Seq_LNCaP_Human1.50196637
92TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.49874437
93RNF2_27304074_Chip-Seq_NSC_Mouse1.49191414
94SPI1_23547873_ChIP-Seq_NB4_Human1.48197818
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46838356
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.46838356
97HOXB4_20404135_ChIP-ChIP_EML_Mouse1.46755311
98CIITA_25753668_ChIP-Seq_RAJI_Human1.46384680
99CBP_20019798_ChIP-Seq_JUKART_Human1.43403157
100IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43403157
101TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.40124397
102AR_25329375_ChIP-Seq_VCAP_Human1.39459526
103TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37577260
104POU5F1_16153702_ChIP-ChIP_HESCs_Human1.37562398
105KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.36463785
106BCAT_22108803_ChIP-Seq_LS180_Human1.36260547
107ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35447981
108REST_21632747_ChIP-Seq_MESCs_Mouse1.34625782
109NR3C1_21868756_ChIP-Seq_MCF10A_Human1.34525790
110GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.34254802
111NANOG_18555785_Chip-Seq_ESCs_Mouse1.32981968
112NANOG_18555785_ChIP-Seq_MESCs_Mouse1.32388955
113MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31828978
114MYC_22102868_ChIP-Seq_BL_Human1.30447149
115PCGF2_27294783_Chip-Seq_ESCs_Mouse1.27317084
116LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.25599057
117ELK1_19687146_ChIP-ChIP_HELA_Human1.25020949
118EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21502564
119EZH2_27294783_Chip-Seq_NPCs_Mouse1.20716616
120RUNX2_22187159_ChIP-Seq_PCA_Human1.20077392
121CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.18547021
122TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18242425
123SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.18208472
124SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17685122
125KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17610397
126BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17417524
127SOX9_26525672_Chip-Seq_HEART_Mouse1.17043861
128CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.17035343
129TCF4_22108803_ChIP-Seq_LS180_Human1.16824871
130MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.16197662
131CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15177080
132POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.14877620
133E2F1_18555785_Chip-Seq_ESCs_Mouse1.14469466
134SOX2_21211035_ChIP-Seq_LN229_Gbm1.13344970
135P53_22387025_ChIP-Seq_ESCs_Mouse1.12895994
136TP53_16413492_ChIP-PET_HCT116_Human1.12818258
137PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11760598
138RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11232702
139STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10668409
140FLI1_21867929_ChIP-Seq_TH2_Mouse1.10200319
141KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09983418
142PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08727831
143CTCF_18555785_ChIP-Seq_MESCs_Mouse1.06508469
144FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06217506
145YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06170965
146JUN_21703547_ChIP-Seq_K562_Human1.05795911
147NFE2_27457419_Chip-Seq_LIVER_Mouse1.05585315
148TAL1_26923725_Chip-Seq_HPCs_Mouse1.05184718
149LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04690970
150CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04081173
151ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03922900
152CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.03798050
153EZH2_27304074_Chip-Seq_ESCs_Mouse1.03038464
154GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01242849
155CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00824624
156MYC_18940864_ChIP-ChIP_HL60_Human1.00816092
157RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00592802
158GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00520010
159SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00203072
160CMYC_18555785_Chip-Seq_ESCs_Mouse1.00187547
161TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00048689
162HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.99484041
163SMAD4_21741376_ChIP-Seq_EPCs_Human0.99195200
164TP63_19390658_ChIP-ChIP_HaCaT_Human0.98863838
165MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.98804144
166VDR_24763502_ChIP-Seq_THP-1_Human0.98744820
167SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98634066
168PRDM14_20953172_ChIP-Seq_ESCs_Human0.98423942
169E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98011903
170EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.97231565
171IRF1_19129219_ChIP-ChIP_H3396_Human0.97051390
172PU.1_20513432_ChIP-Seq_Bcells_Mouse0.95828599
173FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93449536
174SRY_22984422_ChIP-ChIP_TESTIS_Rat0.91255997
175IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.89491942
176POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.88048422
177STAT4_19710469_ChIP-ChIP_TH1__Mouse0.86117068
178FOXM1_23109430_ChIP-Seq_U2OS_Human0.85861664
179RUNX1_22412390_ChIP-Seq_EML_Mouse0.85712716
180YY1_22570637_ChIP-Seq_MALME-3M_Human0.84708500
181ELK1_22589737_ChIP-Seq_MCF10A_Human0.82838655
182NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.82771799
183STAT3_1855785_ChIP-Seq_MESCs_Mouse0.82729001
184E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.80599975
185TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.75878490
186PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.75691634
187IRF8_21731497_ChIP-ChIP_J774_Mouse0.75415899
188PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.74771628
189AR_21909140_ChIP-Seq_LNCAP_Human0.74356695
190CTCF_26484167_Chip-Seq_Bcells_Mouse0.72981817
191ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.71829708
192RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.70008811

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.55385615
2MP0003693_abnormal_embryo_hatching3.42361162
3MP0003646_muscle_fatigue3.22678610
4MP0001188_hyperpigmentation3.09483976
5MP0000569_abnormal_digit_pigmentation3.08003999
6MP0005409_darkened_coat_color3.04935613
7MP0005174_abnormal_tail_pigmentation3.03045404
8MP0006292_abnormal_olfactory_placode2.96613517
9MP0010094_abnormal_chromosome_stability2.94263531
10MP0003806_abnormal_nucleotide_metabolis2.80424976
11MP0008877_abnormal_DNA_methylation2.78238487
12MP0008058_abnormal_DNA_repair2.74880188
13MP0002396_abnormal_hematopoietic_system2.71273139
14MP0003111_abnormal_nucleus_morphology2.42256680
15MP0008057_abnormal_DNA_replication2.42248038
16MP0003787_abnormal_imprinting2.40703291
17MP0000778_abnormal_nervous_system2.37567059
18MP0001853_heart_inflammation2.34236422
19MP0003724_increased_susceptibility_to2.32720750
20MP0005075_abnormal_melanosome_morpholog2.30632645
21MP0000490_abnormal_crypts_of2.28303006
22MP0004957_abnormal_blastocyst_morpholog2.19872810
23MP0000015_abnormal_ear_pigmentation2.05694550
24MP0008007_abnormal_cellular_replicative2.04262941
25MP0003077_abnormal_cell_cycle2.04096841
26MP0002102_abnormal_ear_morphology2.03644739
27MP0003136_yellow_coat_color2.01783044
28MP0003303_peritoneal_inflammation2.01212209
29MP0004147_increased_porphyrin_level1.95964620
30MP0009046_muscle_twitch1.88535679
31MP0003121_genomic_imprinting1.83922862
32MP0003890_abnormal_embryonic-extraembry1.80585025
33MP0001529_abnormal_vocalization1.78806258
34MP0003879_abnormal_hair_cell1.78393640
35MP0000681_abnormal_thyroid_gland1.78201300
36MP0001984_abnormal_olfaction1.77870234
37MP0002876_abnormal_thyroid_physiology1.77054960
38MP0003880_abnormal_central_pattern1.71977478
39MP0001486_abnormal_startle_reflex1.71905534
40MP0004270_analgesia1.71662551
41MP0005551_abnormal_eye_electrophysiolog1.71514498
42MP0002095_abnormal_skin_pigmentation1.71173472
43MP0005423_abnormal_somatic_nervous1.69599094
44MP0004133_heterotaxia1.67961118
45MP0006072_abnormal_retinal_apoptosis1.65423339
46MP0003123_paternal_imprinting1.64721947
47MP0003436_decreased_susceptibility_to1.63056415
48MP0009785_altered_susceptibility_to1.62041654
49MP0006276_abnormal_autonomic_nervous1.59805692
50MP0002272_abnormal_nervous_system1.58410233
51MP0003635_abnormal_synaptic_transmissio1.57299611
52MP0005253_abnormal_eye_physiology1.57281652
53MP0009333_abnormal_splenocyte_physiolog1.56745970
54MP0009745_abnormal_behavioral_response1.56637467
55MP0003763_abnormal_thymus_physiology1.54939397
56MP0003122_maternal_imprinting1.54659440
57MP0000631_abnormal_neuroendocrine_gland1.54283953
58MP0002938_white_spotting1.53154297
59MP0001835_abnormal_antigen_presentation1.52497152
60MP0002734_abnormal_mechanical_nocicepti1.48384718
61MP0008789_abnormal_olfactory_epithelium1.47144506
62MP0002148_abnormal_hypersensitivity_rea1.45034795
63MP0004885_abnormal_endolymph1.44068298
64MP0000427_abnormal_hair_cycle1.43115167
65MP0005394_taste/olfaction_phenotype1.42251830
66MP0005499_abnormal_olfactory_system1.42251830
67MP0000678_abnormal_parathyroid_gland1.41833930
68MP0001293_anophthalmia1.39025739
69MP0002234_abnormal_pharynx_morphology1.38005664
70MP0005025_abnormal_response_to1.37373782
71MP0002184_abnormal_innervation1.37221550
72MP0005187_abnormal_penis_morphology1.37075878
73MP0003937_abnormal_limbs/digits/tail_de1.35840335
74MP0003186_abnormal_redox_activity1.35182241
75MP0002063_abnormal_learning/memory/cond1.33801922
76MP0008932_abnormal_embryonic_tissue1.33602346
77MP0000955_abnormal_spinal_cord1.30478186
78MP0002572_abnormal_emotion/affect_behav1.29006969
79MP0000383_abnormal_hair_follicle1.28488403
80MP0002419_abnormal_innate_immunity1.26252954
81MP0002064_seizures1.26145065
82MP0002557_abnormal_social/conspecific_i1.26029985
83MP0002398_abnormal_bone_marrow1.25628263
84MP0005266_abnormal_metabolism1.25307826
85MP0000358_abnormal_cell_content/1.24774069
86MP0000689_abnormal_spleen_morphology1.23845190
87MP0005397_hematopoietic_system_phenotyp1.23546294
88MP0001545_abnormal_hematopoietic_system1.23546294
89MP0002067_abnormal_sensory_capabilities1.23191024
90MP0008260_abnormal_autophagy1.20823979
91MP0004142_abnormal_muscle_tone1.19033782
92MP0002882_abnormal_neuron_morphology1.18690261
93MP0002019_abnormal_tumor_incidence1.18320986
94MP0000465_gastrointestinal_hemorrhage1.17668663
95MP0002653_abnormal_ependyma_morphology1.16904164
96MP0000647_abnormal_sebaceous_gland1.16454054
97MP0003861_abnormal_nervous_system1.16267134
98MP0001485_abnormal_pinna_reflex1.15880414
99MP0002420_abnormal_adaptive_immunity1.15879920
100MP0002735_abnormal_chemical_nociception1.15539360
101MP0004742_abnormal_vestibular_system1.15403338
102MP0002752_abnormal_somatic_nervous1.15206852
103MP0001819_abnormal_immune_cell1.14008331
104MP0002233_abnormal_nose_morphology1.13837086
105MP0005386_behavior/neurological_phenoty1.13497046
106MP0004924_abnormal_behavior1.13497046
107MP0006036_abnormal_mitochondrial_physio1.12289080
108MP0000685_abnormal_immune_system1.12085596
109MP0001286_abnormal_eye_development1.11767528
110MP0003786_premature_aging1.11598067
111MP0001986_abnormal_taste_sensitivity1.10437346
112MP0005671_abnormal_response_to1.10059739
113MP0000716_abnormal_immune_system1.09512377
114MP0002751_abnormal_autonomic_nervous1.09028008
115MP0005000_abnormal_immune_tolerance1.08736165
116MP0002722_abnormal_immune_system1.08471126
117MP0009697_abnormal_copulation1.08202061
118MP0004811_abnormal_neuron_physiology1.07780026
119MP0002152_abnormal_brain_morphology1.07654432
120MP0002160_abnormal_reproductive_system1.06991050
121MP0002429_abnormal_blood_cell1.05935847
122MP0002723_abnormal_immune_serum1.05864412
123MP0000613_abnormal_salivary_gland1.02692514
124MP0005645_abnormal_hypothalamus_physiol1.02551965
125MP0005391_vision/eye_phenotype1.02099492
126MP0000858_altered_metastatic_potential1.01066439
127MP0005195_abnormal_posterior_eye1.00549002
128MP0001299_abnormal_eye_distance/0.98943847
129MP0000049_abnormal_middle_ear0.97854725
130MP0001970_abnormal_pain_threshold0.97488494
131MP0001905_abnormal_dopamine_level0.95760035
132MP0003755_abnormal_palate_morphology0.95405032
133MP0002075_abnormal_coat/hair_pigmentati0.93207419
134MP0001929_abnormal_gametogenesis0.92859445
135MP0001968_abnormal_touch/_nociception0.91509229
136MP0005248_abnormal_Harderian_gland0.90613424
137MP0002452_abnormal_antigen_presenting0.90242578
138MP0003698_abnormal_male_reproductive0.88930315
139MP0000313_abnormal_cell_death0.88002239
140MP0004808_abnormal_hematopoietic_stem0.87257149
141MP0001800_abnormal_humoral_immune0.86955669
142MP0002822_catalepsy0.86773933
143MP0006035_abnormal_mitochondrial_morpho0.86640561
144MP0005646_abnormal_pituitary_gland0.86452714
145MP0003718_maternal_effect0.85374362
146MP0002009_preneoplasia0.84424807
147MP0003935_abnormal_craniofacial_develop0.83920418
148MP0003119_abnormal_digestive_system0.83561300
149MP0002638_abnormal_pupillary_reflex0.82507454
150MP0002733_abnormal_thermal_nociception0.82361997
151MP0004859_abnormal_synaptic_plasticity0.82264011
152MP0005595_abnormal_vascular_smooth0.81137202
153MP0002928_abnormal_bile_duct0.81049214
154MP0010678_abnormal_skin_adnexa0.80794988
155MP0001502_abnormal_circadian_rhythm0.80637749
156MP0003866_abnormal_defecation0.79943501
157MP0008469_abnormal_protein_level0.79791765
158MP0002697_abnormal_eye_size0.78431254
159MP0003172_abnormal_lysosome_physiology0.78210217
160MP0000751_myopathy0.77160484
161MP0000026_abnormal_inner_ear0.76659858
162MP0000372_irregular_coat_pigmentation0.76256255
163MP0003938_abnormal_ear_development0.76006495
164MP0005165_increased_susceptibility_to0.75839912
165MP0001177_atelectasis0.75043263
166MP0001963_abnormal_hearing_physiology0.73783046
167MP0005464_abnormal_platelet_physiology0.72980083
168MP0000703_abnormal_thymus_morphology0.71694052
169MP0000350_abnormal_cell_proliferation0.71088821
170MP0010155_abnormal_intestine_physiology0.68732322
171MP0002736_abnormal_nociception_after0.67847671
172MP0005171_absent_coat_pigmentation0.66773822
173MP0002210_abnormal_sex_determination0.66379484
174MP0001663_abnormal_digestive_system0.64924907
175MP0005376_homeostasis/metabolism_phenot0.64757321
176MP0001845_abnormal_inflammatory_respons0.64248534
177MP0002132_abnormal_respiratory_system0.62851407

Predicted human phenotypes

RankGene SetZ-score
1Reduced antithrombin III activity (HP:0001976)8.53377739
2Type I transferrin isoform profile (HP:0003642)7.52098678
3Abnormal glycosylation (HP:0012345)5.39939988
4Abnormal isoelectric focusing of serum transferrin (HP:0003160)5.39939988
5Abnormal protein N-linked glycosylation (HP:0012347)5.39939988
6Abnormal protein glycosylation (HP:0012346)5.39939988
7Thyroid-stimulating hormone excess (HP:0002925)4.90871258
8Abnormal number of erythroid precursors (HP:0012131)4.60611815
9Abnormality of cells of the erythroid lineage (HP:0012130)4.55173105
10Hypothermia (HP:0002045)4.00168661
11Annular pancreas (HP:0001734)3.81555093
12Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.62060996
13Thrombocytosis (HP:0001894)3.46510828
14Reticulocytopenia (HP:0001896)3.44460316
15Severe visual impairment (HP:0001141)3.40888808
16Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.40378465
17Hyperventilation (HP:0002883)3.37549790
18Hepatocellular necrosis (HP:0001404)3.33548253
19Pancreatic cysts (HP:0001737)3.32985658
20Molar tooth sign on MRI (HP:0002419)3.31118179
21Abnormality of midbrain morphology (HP:0002418)3.31118179
22Pancreatic fibrosis (HP:0100732)3.30464631
23Birth length less than 3rd percentile (HP:0003561)3.30022862
24True hermaphroditism (HP:0010459)3.27940038
25Volvulus (HP:0002580)3.14486881
26Macrocytic anemia (HP:0001972)3.14425503
27Gait imbalance (HP:0002141)3.13322324
28Medial flaring of the eyebrow (HP:0010747)3.12441541
29Hepatic necrosis (HP:0002605)3.09017257
30Abnormality of the axillary hair (HP:0100134)3.08794361
31Abnormality of secondary sexual hair (HP:0009888)3.08794361
32Cortical visual impairment (HP:0100704)3.07814499
33Increased hepatocellular lipid droplets (HP:0006565)3.05499535
34Ankle contracture (HP:0006466)3.05409475
35Nephronophthisis (HP:0000090)3.03498244
36Congenital primary aphakia (HP:0007707)2.94526740
37Agnosia (HP:0010524)2.93177367
38Aplastic anemia (HP:0001915)2.76625528
39Nephrogenic diabetes insipidus (HP:0009806)2.76376257
40Chronic hepatic failure (HP:0100626)2.76181037
41Exertional dyspnea (HP:0002875)2.76064691
42Aplasia/Hypoplasia of the sacrum (HP:0008517)2.75398986
43Pallor (HP:0000980)2.74598598
44Elevated erythrocyte sedimentation rate (HP:0003565)2.74551250
45Renal Fanconi syndrome (HP:0001994)2.74270919
46Prolonged partial thromboplastin time (HP:0003645)2.72190493
47Thoracic kyphosis (HP:0002942)2.71909674
48Oral leukoplakia (HP:0002745)2.71763338
49Oligodactyly (hands) (HP:0001180)2.70464078
50Lipid accumulation in hepatocytes (HP:0006561)2.68975112
51Intestinal atresia (HP:0011100)2.67576062
52Abnormality of magnesium homeostasis (HP:0004921)2.63370723
53Genital tract atresia (HP:0001827)2.62826654
54Abnormality of the renal medulla (HP:0100957)2.58124361
55Vaginal atresia (HP:0000148)2.57320049
56Increased intramyocellular lipid droplets (HP:0012240)2.55418763
57Breast hypoplasia (HP:0003187)2.54702270
58Poor coordination (HP:0002370)2.53551160
59Decreased activity of mitochondrial respiratory chain (HP:0008972)2.52353084
60Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.52353084
61Abnormality of the labia minora (HP:0012880)2.52105358
62Progressive muscle weakness (HP:0003323)2.48625734
63Flat occiput (HP:0005469)2.47615615
64Drooling (HP:0002307)2.47502936
65Absent rod-and cone-mediated responses on ERG (HP:0007688)2.44482498
66Sex reversal (HP:0012245)2.44194434
67Abnormal sex determination (HP:0012244)2.44194434
68Aplasia/Hypoplasia of the uvula (HP:0010293)2.43968120
69Microretrognathia (HP:0000308)2.42958341
70Focal motor seizures (HP:0011153)2.42503280
71Ocular albinism (HP:0001107)2.42236757
72IgM deficiency (HP:0002850)2.40774763
73Febrile seizures (HP:0002373)2.39883326
74Chromsome breakage (HP:0040012)2.39459240
75Chromosomal breakage induced by crosslinking agents (HP:0003221)2.37338659
76Colon cancer (HP:0003003)2.37000102
77Focal seizures (HP:0007359)2.36381544
78Microvesicular hepatic steatosis (HP:0001414)2.33961606
79Lissencephaly (HP:0001339)2.33720294
80Abnormality of chromosome stability (HP:0003220)2.33587815
81Increased serum lactate (HP:0002151)2.31791441
82Megaloblastic anemia (HP:0001889)2.31235226
83Broad-based gait (HP:0002136)2.26412155
84Acute lymphatic leukemia (HP:0006721)2.25019777
85Gaze-evoked nystagmus (HP:0000640)2.23984951
86Abnormality of the prostate (HP:0008775)2.22546210
87Increased muscle lipid content (HP:0009058)2.21100447
88Postaxial foot polydactyly (HP:0001830)2.19290866
89Excessive salivation (HP:0003781)2.18761857
90Lower limb hyperreflexia (HP:0002395)2.16758272
91Abnormal ciliary motility (HP:0012262)2.16659869
92Anencephaly (HP:0002323)2.16572115
93Absent/shortened dynein arms (HP:0200106)2.16094883
94Dynein arm defect of respiratory motile cilia (HP:0012255)2.16094883
95Postaxial hand polydactyly (HP:0001162)2.11896704
96Abnormality of the astrocytes (HP:0100707)2.11354610
97Astrocytoma (HP:0009592)2.11354610
98Progressive cerebellar ataxia (HP:0002073)2.11163812
99Type 2 muscle fiber atrophy (HP:0003554)2.10973414
100Cystic liver disease (HP:0006706)2.10423635
101Aplasia/Hypoplasia of the tongue (HP:0010295)2.10392857
102Optic nerve hypoplasia (HP:0000609)2.08134232
103Supernumerary spleens (HP:0009799)2.07085522
104Absent speech (HP:0001344)2.06420909
105Protruding tongue (HP:0010808)2.06252899
106Self-mutilation (HP:0000742)2.05909184
107Cerebellar dysplasia (HP:0007033)2.04469621
108Granulocytopenia (HP:0001913)2.04151475
109Mitochondrial inheritance (HP:0001427)2.02808151
110Pulmonary fibrosis (HP:0002206)2.02602561
111Meckel diverticulum (HP:0002245)2.02465190
112Tubulointerstitial nephritis (HP:0001970)2.02127468
113Abnormality of the renal cortex (HP:0011035)2.01759834
114Sclerocornea (HP:0000647)2.01590638
115Muscle fiber atrophy (HP:0100295)2.01571303
116Glioma (HP:0009733)2.00953069
117Specific learning disability (HP:0001328)1.99679151
118Iris hypopigmentation (HP:0007730)1.99210455
119Pancytopenia (HP:0001876)1.99017141
120Respiratory difficulties (HP:0002880)1.98428487
121Hyperalaninemia (HP:0003348)1.98186057
122Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.98186057
123Abnormality of alanine metabolism (HP:0010916)1.98186057
124Abnormal respiratory epithelium morphology (HP:0012253)1.97662492
125Abnormal respiratory motile cilium morphology (HP:0005938)1.97662492
126Preaxial hand polydactyly (HP:0001177)1.97385709
127Increased CSF lactate (HP:0002490)1.96919997
128Spinal canal stenosis (HP:0003416)1.95830115
129Papillary thyroid carcinoma (HP:0002895)1.95817353
130Type II lissencephaly (HP:0007260)1.95583880
131Sloping forehead (HP:0000340)1.95319801
132Myositis (HP:0100614)1.94665032
133Split foot (HP:0001839)1.93436764
134Astigmatism (HP:0000483)1.93266950
135Obstructive sleep apnea (HP:0002870)1.92860509
136Medulloblastoma (HP:0002885)1.92351003
137Abnormal respiratory motile cilium physiology (HP:0012261)1.91547428
1383-Methylglutaconic aciduria (HP:0003535)1.90633673
139Abnormality of the thoracic spine (HP:0100711)1.90462445
140Abnormality of the ileum (HP:0001549)1.89664860
141Dialeptic seizures (HP:0011146)1.89456393
142Abnormality of the preputium (HP:0100587)1.89104874
143Hip dysplasia (HP:0001385)1.88328346
144Knee flexion contracture (HP:0006380)1.88240180
145Pachygyria (HP:0001302)1.88185975
146Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.87881528
147Microcytic anemia (HP:0001935)1.87795888
148Rough bone trabeculation (HP:0100670)1.87626074
149Oligodactyly (HP:0012165)1.87001834
150Abnormality of the columella (HP:0009929)1.86940445
151Aplasia/Hypoplasia of the tibia (HP:0005772)1.86695375
152Narrow forehead (HP:0000341)1.86560840
153Atonic seizures (HP:0010819)1.86072335
154Abnormality of B cell number (HP:0010975)1.85953143
155B lymphocytopenia (HP:0010976)1.85953143
156Decreased circulating renin level (HP:0003351)1.85411531
157Abnormality of the heme biosynthetic pathway (HP:0010472)1.84690055
158Retinal dysplasia (HP:0007973)1.84570183
159Rhabdomyosarcoma (HP:0002859)1.84310364
160Petechiae (HP:0000967)1.83270420
161Ectopic kidney (HP:0000086)1.82543761
162Congenital stationary night blindness (HP:0007642)1.81748257
163Abnormal spermatogenesis (HP:0008669)1.81671180
164Rhinitis (HP:0012384)1.79663298
165Postnatal microcephaly (HP:0005484)1.79570143
166Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.78960813
167Exercise intolerance (HP:0003546)1.78845276
168Hemiparesis (HP:0001269)1.78716125
169Small hand (HP:0200055)1.78676966
170Dandy-Walker malformation (HP:0001305)1.78616459
171Abnormality of the corticospinal tract (HP:0002492)1.78493563
172Highly arched eyebrow (HP:0002553)1.77629013
173Aqueductal stenosis (HP:0002410)1.77321946
174Cortical dysplasia (HP:0002539)1.76899427
175Short foot (HP:0001773)1.76863665
176Prominent nasal bridge (HP:0000426)1.76754998
177Selective tooth agenesis (HP:0001592)1.75914641
178Genetic anticipation (HP:0003743)1.75227549
179Chronic otitis media (HP:0000389)1.74977778
180Progressive inability to walk (HP:0002505)1.74856805
181Premature graying of hair (HP:0002216)1.73636351
182Late onset (HP:0003584)1.73433159
183Poikiloderma (HP:0001029)1.72558215
184Abnormality of DNA repair (HP:0003254)1.72491583
185Aplasia/Hypoplasia of the sternum (HP:0006714)1.71458855
186Chronic obstructive pulmonary disease (HP:0006510)1.71293383
187Obstructive lung disease (HP:0006536)1.71293383
188Small intestinal stenosis (HP:0012848)1.70525339
189Duodenal stenosis (HP:0100867)1.70525339
190Mitral regurgitation (HP:0001653)1.70365801
191Gastrointestinal atresia (HP:0002589)1.69883077
192Renal hypoplasia (HP:0000089)1.69718767
193Neoplasm of the oral cavity (HP:0100649)1.69126098
194Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.68865048
195Degeneration of the lateral corticospinal tracts (HP:0002314)1.68865048
196Abnormality of the duodenum (HP:0002246)1.68365524
197Broad foot (HP:0001769)1.68197238

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK9.01951030
2EIF2AK37.21963948
3FRK3.64269925
4CASK3.54144156
5STK163.33023354
6MAP3K43.03980081
7MARK12.94071898
8NLK2.86751071
9FES2.58549629
10BUB12.45121752
11WEE12.44926710
12PNCK2.38519560
13CAMKK22.33619177
14WNK32.29042209
15EIF2AK22.25918930
16BCR2.23508060
17BMPR1B2.13128735
18MKNK22.04732432
19TRIM281.96465287
20NTRK31.70695460
21SCYL21.69185692
22IRAK31.57775405
23ERBB31.55376167
24FLT31.54538273
25VRK11.54186209
26NUAK11.50113640
27INSRR1.47329335
28IRAK41.44430531
29MKNK11.41161150
30TEC1.39856588
31EIF2AK11.38112324
32PLK41.36368930
33KIT1.35373111
34CDK191.34170938
35NME21.32514990
36STK391.28197952
37PIM21.26293246
38DYRK21.26027497
39NTRK21.24965319
40MAPKAPK31.22105679
41BRD41.22096876
42PLK21.19445948
43NEK11.15978208
44PLK31.15756581
45PAK31.12826923
46CDC71.12536327
47TLK11.10888956
48SRPK11.10577863
49CSNK1G21.09209706
50MAP4K21.06166673
51ZAK1.02683818
52TESK21.02619768
53STK38L0.99854283
54PINK10.98923540
55ACVR1B0.96634587
56TSSK60.96395132
57KDR0.96357903
58UHMK10.94990814
59MINK10.94367928
60MAP2K70.94218529
61TAOK20.92579701
62PRKCG0.92182640
63BCKDK0.90939144
64CSNK1G10.90540997
65SGK20.89536450
66RPS6KB20.88094541
67FGFR20.87095244
68CDK70.86968409
69CSNK1A1L0.86910021
70CAMK10.85138108
71MAP2K40.83281732
72EPHA40.81711394
73STK30.81098532
74AKT30.80491080
75CAMK1G0.80196024
76OXSR10.80014209
77KSR10.79478763
78LATS10.79353162
79MAP3K60.77102348
80PRPF4B0.76837291
81CSNK1G30.76242502
82BTK0.75632588
83PRKCE0.73698934
84GRK10.73693832
85ATM0.72984750
86CDK30.72519853
87DYRK30.71904689
88SIK20.69463324
89DYRK1A0.66946182
90ATR0.64078824
91PKN10.63439806
92WNK40.63349636
93DAPK10.63182876
94SGK4940.62366390
95SGK2230.62366390
96BRSK20.62033352
97PAK40.59973734
98MAP2K30.59122060
99MAP3K110.57781393
100MUSK0.57444443
101CSF1R0.57440770
102CSNK1D0.57389745
103YES10.56538779
104PBK0.53511105
105PLK10.52603974
106CAMK2A0.52458375
107WNK10.51512231
108STK110.50392830
109CAMKK10.48044691
110CDK80.47917711
111CLK10.47905317
112MAP4K10.47789085
113LYN0.47440350
114CDK50.47072593
115AURKA0.46982183
116CAMK1D0.46898702
117CDK10.44195325
118TTK0.43692855
119MAPK130.43472545
120RPS6KA40.42947279
121ERN10.42117675
122SYK0.41983644
123MATK0.41872000
124CSNK1E0.41336068
125ABL20.41326176
126CCNB10.40775285
127PHKG10.40272400
128PHKG20.40272400
129CHEK10.39941758
130BLK0.39110600
131MAPK150.38854374
132PRKDC0.38796781
133PRKACB0.37891773
134AURKB0.37577262
135FER0.36429318
136ADRBK10.36249590
137MAPK40.35967643
138CAMK2B0.35832695
139OBSCN0.35500933
140MARK20.34784791
141MAP3K80.34757079
142CSNK2A20.33741936
143TESK10.32573798
144CHEK20.32571901
145PAK10.31685911
146MAP3K10.30625983
147BRSK10.28834679
148TYK20.28228259
149MAP2K60.28146770
150MAP3K120.27551413
151PRKCI0.26735689
152ZAP700.25404629
153LCK0.25271688
154RAF10.24583029
155CDK40.24326701
156IRAK10.23971388
157CSNK2A10.23725487
158NEK20.23375064
159MAPKAPK50.18803320
160TGFBR10.17676071
161IRAK20.17346163
162MAPK110.16838492
163MAP3K50.15732988
164IKBKB0.14494654
165ADRBK20.14094327
166CAMK40.13413528
167HCK0.13313838

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030306.40664299
2Ribosome_Homo sapiens_hsa030104.77626889
3Mismatch repair_Homo sapiens_hsa034304.29759049
4Base excision repair_Homo sapiens_hsa034103.03972174
5Homologous recombination_Homo sapiens_hsa034403.00514011
6Nucleotide excision repair_Homo sapiens_hsa034202.77688688
7Pyrimidine metabolism_Homo sapiens_hsa002402.76338475
8Proteasome_Homo sapiens_hsa030502.73104594
9Spliceosome_Homo sapiens_hsa030402.50564117
10RNA polymerase_Homo sapiens_hsa030202.46174533
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.26144802
12N-Glycan biosynthesis_Homo sapiens_hsa005102.25305655
13One carbon pool by folate_Homo sapiens_hsa006702.25101242
14Phototransduction_Homo sapiens_hsa047442.18335881
15Protein export_Homo sapiens_hsa030602.11103841
16Thyroid cancer_Homo sapiens_hsa052162.00653482
17Fanconi anemia pathway_Homo sapiens_hsa034602.00277615
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.91228869
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.85781155
20Glutamatergic synapse_Homo sapiens_hsa047241.80183412
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.80060562
22Taste transduction_Homo sapiens_hsa047421.77903820
23GABAergic synapse_Homo sapiens_hsa047271.77647965
24Propanoate metabolism_Homo sapiens_hsa006401.68699722
25Morphine addiction_Homo sapiens_hsa050321.67645650
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.66144033
27Non-homologous end-joining_Homo sapiens_hsa034501.63397983
28Purine metabolism_Homo sapiens_hsa002301.57698996
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.56592723
30Dopaminergic synapse_Homo sapiens_hsa047281.51857030
31Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.49779845
32Butanoate metabolism_Homo sapiens_hsa006501.41027417
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.40923611
34RNA transport_Homo sapiens_hsa030131.39830060
35Renin-angiotensin system_Homo sapiens_hsa046141.39156823
36Cell cycle_Homo sapiens_hsa041101.34600201
37Axon guidance_Homo sapiens_hsa043601.34111325
38Other glycan degradation_Homo sapiens_hsa005111.31171891
39Olfactory transduction_Homo sapiens_hsa047401.27645481
40Hedgehog signaling pathway_Homo sapiens_hsa043401.27347852
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.26444898
42Oocyte meiosis_Homo sapiens_hsa041141.25820660
43Basal transcription factors_Homo sapiens_hsa030221.25655239
44p53 signaling pathway_Homo sapiens_hsa041151.22693455
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.22148411
46Cocaine addiction_Homo sapiens_hsa050301.22009321
47Folate biosynthesis_Homo sapiens_hsa007901.20636565
48Long-term depression_Homo sapiens_hsa047301.19972059
49Nitrogen metabolism_Homo sapiens_hsa009101.19460980
50Insulin secretion_Homo sapiens_hsa049111.17872402
51RNA degradation_Homo sapiens_hsa030181.17453985
52Dorso-ventral axis formation_Homo sapiens_hsa043201.16701969
53Steroid biosynthesis_Homo sapiens_hsa001001.16500844
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16449415
55Hippo signaling pathway_Homo sapiens_hsa043901.14852749
56Pentose phosphate pathway_Homo sapiens_hsa000301.14479716
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.11808051
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.08084529
59Amphetamine addiction_Homo sapiens_hsa050311.06181419
60Basal cell carcinoma_Homo sapiens_hsa052171.06014654
61Cyanoamino acid metabolism_Homo sapiens_hsa004601.05466094
62Serotonergic synapse_Homo sapiens_hsa047261.03146083
63Systemic lupus erythematosus_Homo sapiens_hsa053221.02991447
64Ether lipid metabolism_Homo sapiens_hsa005651.02273141
65Cysteine and methionine metabolism_Homo sapiens_hsa002701.01033019
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.00206514
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.99909187
68Cholinergic synapse_Homo sapiens_hsa047250.99495692
69Primary immunodeficiency_Homo sapiens_hsa053400.96842338
70Glutathione metabolism_Homo sapiens_hsa004800.96529566
71Oxidative phosphorylation_Homo sapiens_hsa001900.95150421
72Lysine degradation_Homo sapiens_hsa003100.93923798
73Circadian rhythm_Homo sapiens_hsa047100.93878269
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92884820
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.91476566
76Sulfur relay system_Homo sapiens_hsa041220.90305699
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86094706
78Maturity onset diabetes of the young_Homo sapiens_hsa049500.84990135
79Salivary secretion_Homo sapiens_hsa049700.84858878
80mRNA surveillance pathway_Homo sapiens_hsa030150.84632334
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84611336
82Wnt signaling pathway_Homo sapiens_hsa043100.83445031
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.81624738
84Herpes simplex infection_Homo sapiens_hsa051680.80766986
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77813044
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.76810829
87cAMP signaling pathway_Homo sapiens_hsa040240.76520591
88TGF-beta signaling pathway_Homo sapiens_hsa043500.75693981
89Gap junction_Homo sapiens_hsa045400.74940629
90Colorectal cancer_Homo sapiens_hsa052100.73810809
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71634769
92Parkinsons disease_Homo sapiens_hsa050120.70246560
93Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70119838
94Linoleic acid metabolism_Homo sapiens_hsa005910.69299901
95Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.68987425
96beta-Alanine metabolism_Homo sapiens_hsa004100.66915127
97Biosynthesis of amino acids_Homo sapiens_hsa012300.65941542
98Huntingtons disease_Homo sapiens_hsa050160.63518311
99Oxytocin signaling pathway_Homo sapiens_hsa049210.61228460
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60434529
101Type II diabetes mellitus_Homo sapiens_hsa049300.60245672
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59406273
103Acute myeloid leukemia_Homo sapiens_hsa052210.57826652
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57601217
105Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57589252
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54934416
107Synaptic vesicle cycle_Homo sapiens_hsa047210.54870578
108Selenocompound metabolism_Homo sapiens_hsa004500.54426620
109Metabolic pathways_Homo sapiens_hsa011000.54118749
110Gastric acid secretion_Homo sapiens_hsa049710.51715887
111Melanogenesis_Homo sapiens_hsa049160.51125702
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50895463
113Melanoma_Homo sapiens_hsa052180.50791123
114Tryptophan metabolism_Homo sapiens_hsa003800.49934121
115Tight junction_Homo sapiens_hsa045300.49606282
116Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49377941
117Renin secretion_Homo sapiens_hsa049240.48131690
118ABC transporters_Homo sapiens_hsa020100.47036983
119Peroxisome_Homo sapiens_hsa041460.45245977
120cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45178718
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45162558
122Epstein-Barr virus infection_Homo sapiens_hsa051690.44884436
123Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44139119
1242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43369972
125Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40386819
126Nicotine addiction_Homo sapiens_hsa050330.38541096
127Alzheimers disease_Homo sapiens_hsa050100.37413573
128Arachidonic acid metabolism_Homo sapiens_hsa005900.36128830
129Leishmaniasis_Homo sapiens_hsa051400.34173835
130Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32746814
131Carbon metabolism_Homo sapiens_hsa012000.32293484
132Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32260019
133Antigen processing and presentation_Homo sapiens_hsa046120.30453932
134Measles_Homo sapiens_hsa051620.28656053
135Alcoholism_Homo sapiens_hsa050340.27617394
136Hematopoietic cell lineage_Homo sapiens_hsa046400.27176796
137Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.27092352
138Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.24532031
139Arginine and proline metabolism_Homo sapiens_hsa003300.24436201
140Vitamin digestion and absorption_Homo sapiens_hsa049770.24363357
141Glycosaminoglycan degradation_Homo sapiens_hsa005310.24007986
142Galactose metabolism_Homo sapiens_hsa000520.23295365
143Shigellosis_Homo sapiens_hsa051310.22546024
144Steroid hormone biosynthesis_Homo sapiens_hsa001400.21774274
145NF-kappa B signaling pathway_Homo sapiens_hsa040640.20185845
146Regulation of autophagy_Homo sapiens_hsa041400.19370098
147Malaria_Homo sapiens_hsa051440.17476396
148Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.16569107
149Aldosterone synthesis and secretion_Homo sapiens_hsa049250.15497713
150Circadian entrainment_Homo sapiens_hsa047130.13064825
151HTLV-I infection_Homo sapiens_hsa051660.12698366
152NOD-like receptor signaling pathway_Homo sapiens_hsa046210.10316587
153Pertussis_Homo sapiens_hsa051330.09352166
154Asthma_Homo sapiens_hsa053100.09230601
155Hepatitis B_Homo sapiens_hsa051610.08848314
156Calcium signaling pathway_Homo sapiens_hsa040200.08707962
157Apoptosis_Homo sapiens_hsa042100.07132690
158Cardiac muscle contraction_Homo sapiens_hsa042600.06897403
159Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.06424706
160Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.05075138
161Toll-like receptor signaling pathway_Homo sapiens_hsa046200.04118045
162Viral carcinogenesis_Homo sapiens_hsa052030.03485456
163Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.03332567
164Intestinal immune network for IgA production_Homo sapiens_hsa046720.03113840

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