CEPT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene codes for a choline/ethanolaminephosphotransferase, which functions in the synthesis of choline- or ethanolamine- containing phospholipids. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.67847491
2regulation of B cell receptor signaling pathway (GO:0050855)5.89816286
3negative regulation of cell killing (GO:0031342)5.32886006
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.32886006
5regulation of gamma-delta T cell activation (GO:0046643)5.14344305
6fatty acid elongation (GO:0030497)5.08066481
7regulation of gamma-delta T cell differentiation (GO:0045586)5.01133685
8central nervous system myelination (GO:0022010)4.80874714
9axon ensheathment in central nervous system (GO:0032291)4.80874714
10L-phenylalanine catabolic process (GO:0006559)4.58086406
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.58086406
12positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.54174409
13B cell receptor signaling pathway (GO:0050853)4.49169885
14positive regulation of B cell differentiation (GO:0045579)4.38863197
15antigen processing and presentation of endogenous antigen (GO:0019883)4.32981732
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.29076877
17negative T cell selection (GO:0043383)4.24400267
18negative thymic T cell selection (GO:0045060)4.14205741
19positive regulation of alpha-beta T cell proliferation (GO:0046641)4.02595283
20regulation of alpha-beta T cell proliferation (GO:0046640)4.02139962
21antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.99204094
22L-phenylalanine metabolic process (GO:0006558)3.94855967
23erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.94855967
24regulation of B cell differentiation (GO:0045577)3.93992113
25T cell migration (GO:0072678)3.87891569
26interferon-gamma production (GO:0032609)3.82284325
27regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.80697454
28positive thymic T cell selection (GO:0045059)3.76397677
29positive T cell selection (GO:0043368)3.74533932
30regulation of regulatory T cell differentiation (GO:0045589)3.73178094
31response to interleukin-15 (GO:0070672)3.71544136
32negative regulation of T cell mediated immunity (GO:0002710)3.70527089
33aromatic amino acid family catabolic process (GO:0009074)3.69926448
34cellular response to interleukin-15 (GO:0071350)3.65684747
35negative regulation of B cell proliferation (GO:0030889)3.62342950
36regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.61467824
37immunoglobulin mediated immune response (GO:0016064)3.61405449
38negative regulation of lymphocyte mediated immunity (GO:0002707)3.57775881
39aldehyde catabolic process (GO:0046185)3.54629234
40positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.51417042
41positive regulation of granulocyte differentiation (GO:0030854)3.42107148
42opsonization (GO:0008228)3.41033841
43T cell selection (GO:0045058)3.38354167
44cholesterol biosynthetic process (GO:0006695)3.29879088
45cytidine deamination (GO:0009972)3.29036048
46cytidine metabolic process (GO:0046087)3.29036048
47cytidine catabolic process (GO:0006216)3.29036048
48neutrophil activation involved in immune response (GO:0002283)3.26585026
49nucleotide transmembrane transport (GO:1901679)3.26281731
50negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.25914405
51interferon-gamma-mediated signaling pathway (GO:0060333)3.24731625
52activated T cell proliferation (GO:0050798)3.22605137
53negative regulation of interleukin-12 production (GO:0032695)3.19885135
54regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.15777625
55negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.15436259
56B cell mediated immunity (GO:0019724)3.15380932
57antigen receptor-mediated signaling pathway (GO:0050851)3.13305378
58pyrimidine ribonucleoside catabolic process (GO:0046133)3.11537087
59triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.11454074
60cofactor catabolic process (GO:0051187)3.10312177
61negative regulation of T-helper cell differentiation (GO:0045623)3.10261325
62negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.10261325
63very long-chain fatty acid metabolic process (GO:0000038)3.10067350
64regulation of T cell mediated cytotoxicity (GO:0001914)3.06780856
65macrophage activation involved in immune response (GO:0002281)3.06527469
66bile acid biosynthetic process (GO:0006699)3.05786907
67type I interferon signaling pathway (GO:0060337)3.05133256
68cellular response to type I interferon (GO:0071357)3.05133256
69thymic T cell selection (GO:0045061)3.03713480
70response to type I interferon (GO:0034340)3.03404445
71negative regulation of leukocyte mediated immunity (GO:0002704)3.01410546
72negative regulation of adaptive immune response (GO:0002820)3.00891940
73amyloid precursor protein catabolic process (GO:0042987)3.00353253
74T cell costimulation (GO:0031295)2.99363297
75uronic acid metabolic process (GO:0006063)2.98555709
76glucuronate metabolic process (GO:0019585)2.98555709
77cellular response to ethanol (GO:0071361)2.95858864
78lymphocyte costimulation (GO:0031294)2.95504295
79regulation of natural killer cell mediated immunity (GO:0002715)2.93810341
80regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.93810341
81regulation of interferon-beta biosynthetic process (GO:0045357)2.93231402
82tryptophan catabolic process (GO:0006569)2.91574436
83indole-containing compound catabolic process (GO:0042436)2.91574436
84indolalkylamine catabolic process (GO:0046218)2.91574436
85long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.91046422
86positive regulation of T cell mediated cytotoxicity (GO:0001916)2.90201934
87sterol biosynthetic process (GO:0016126)2.86868047
88amyloid precursor protein metabolic process (GO:0042982)2.86493752
89regulation of germinal center formation (GO:0002634)2.85320330
90detection of external biotic stimulus (GO:0098581)2.83806335
91DNA deamination (GO:0045006)2.83179585
92B cell homeostasis (GO:0001782)2.83173803
93regulation of T cell receptor signaling pathway (GO:0050856)2.81109949
94cellular biogenic amine catabolic process (GO:0042402)2.80814519
95amine catabolic process (GO:0009310)2.80814519
96T cell receptor signaling pathway (GO:0050852)2.80460571
97positive regulation of B cell mediated immunity (GO:0002714)2.80228514
98positive regulation of immunoglobulin mediated immune response (GO:0002891)2.80228514
99long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.79965869
100leukocyte aggregation (GO:0070486)2.79886485
101CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.79850162
102negative regulation of alpha-beta T cell activation (GO:0046636)2.79080218
103protein carboxylation (GO:0018214)2.78899361
104peptidyl-glutamic acid carboxylation (GO:0017187)2.78899361
105cholesterol efflux (GO:0033344)2.77887938
106histamine secretion (GO:0001821)2.77588389
107regulation of T cell tolerance induction (GO:0002664)2.76524956
108positive regulation of defense response to virus by host (GO:0002230)2.76271926
109Arp2/3 complex-mediated actin nucleation (GO:0034314)2.75854068
110regulation of leukocyte mediated cytotoxicity (GO:0001910)2.75533108
111regulation of cholesterol esterification (GO:0010872)2.74924136
112fatty-acyl-CoA metabolic process (GO:0035337)2.74745774
113B cell proliferation (GO:0042100)2.74421562
114long-chain fatty acid biosynthetic process (GO:0042759)2.74227314
115fatty-acyl-CoA biosynthetic process (GO:0046949)2.74047505
116tolerance induction (GO:0002507)2.74007068
117regulation of B cell proliferation (GO:0030888)2.73753385
118myeloid cell activation involved in immune response (GO:0002275)2.73641765
119positive regulation of humoral immune response (GO:0002922)2.73420663
120positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.72922733
121regulation of alpha-beta T cell activation (GO:0046634)2.72648005
122fibrinolysis (GO:0042730)2.72518978
123tryptophan metabolic process (GO:0006568)2.72130228
124detection of molecule of bacterial origin (GO:0032490)2.71560106
125plasma lipoprotein particle clearance (GO:0034381)2.71268125
126negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.70941347
127mast cell activation (GO:0045576)2.70890008
128regulation of antigen processing and presentation (GO:0002577)2.70653270
129regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.70358381
130positive regulation of cellular amide metabolic process (GO:0034250)2.70317469
131regulation of T-helper 1 cell differentiation (GO:0045625)2.70229648
132high-density lipoprotein particle remodeling (GO:0034375)2.70149252
133negative regulation of type 2 immune response (GO:0002829)2.68766615
134antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.68360881
135cellular glucuronidation (GO:0052695)2.66599178
136glyoxylate metabolic process (GO:0046487)2.62640910
137coenzyme catabolic process (GO:0009109)2.62295225
138signal peptide processing (GO:0006465)2.59846896
139low-density lipoprotein particle remodeling (GO:0034374)2.57255442
140complement activation, alternative pathway (GO:0006957)2.55834663
141respiratory burst (GO:0045730)2.54483787
142phospholipid efflux (GO:0033700)2.53423644
143very-low-density lipoprotein particle assembly (GO:0034379)2.52058953
144regulation of fibrinolysis (GO:0051917)2.52050444
145protein neddylation (GO:0045116)2.51414672
146bile acid metabolic process (GO:0008206)2.51338932
147negative regulation of neurotransmitter secretion (GO:0046929)2.51018538
148isoprenoid biosynthetic process (GO:0008299)2.50323147
149positive regulation of cellular amine metabolic process (GO:0033240)2.50194656
150regulation of triglyceride catabolic process (GO:0010896)2.49848032
151response to nitrosative stress (GO:0051409)2.49480705
152cysteine metabolic process (GO:0006534)2.48808436
153intracellular pH reduction (GO:0051452)2.46600524
154aromatic amino acid family metabolic process (GO:0009072)2.44977971
155protein-lipid complex remodeling (GO:0034368)2.44951250
156macromolecular complex remodeling (GO:0034367)2.44951250
157plasma lipoprotein particle remodeling (GO:0034369)2.44951250
158modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.44511766
159positive regulation by organism of defense response of other organism involved in symbiotic interact2.44511766
160modulation by symbiont of host immune response (GO:0052553)2.44511766
161positive regulation by symbiont of host defense response (GO:0052509)2.44511766
162modulation by symbiont of host defense response (GO:0052031)2.44511766
163modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.44511766
164sulfur amino acid catabolic process (GO:0000098)2.42709195
165glutathione derivative metabolic process (GO:1901685)2.42579031
166glutathione derivative biosynthetic process (GO:1901687)2.42579031
167positive regulation of interleukin-1 beta secretion (GO:0050718)2.41489220
168positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.40940840
169alpha-linolenic acid metabolic process (GO:0036109)2.40841314
170reverse cholesterol transport (GO:0043691)2.38826482
171regulation of interleukin-1 beta secretion (GO:0050706)2.37588651
172heme transport (GO:0015886)2.37303231
173tyrosine metabolic process (GO:0006570)2.36755106
174detection of other organism (GO:0098543)2.36629327
175positive regulation of interferon-alpha production (GO:0032727)2.36478914
176regulation of collateral sprouting (GO:0048670)2.35786529
177fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.35031672
178positive regulation of toll-like receptor signaling pathway (GO:0034123)2.34968372
179kynurenine metabolic process (GO:0070189)2.34165627
180import into cell (GO:0098657)2.33914410
181regulation of protein activation cascade (GO:2000257)2.32472215
182acyl-CoA metabolic process (GO:0006637)2.32087413
183thioester metabolic process (GO:0035383)2.32087413
184cellular response to exogenous dsRNA (GO:0071360)2.31849828
185microglial cell activation (GO:0001774)2.31713545
186negative regulation of neurotransmitter transport (GO:0051589)2.30808033
187thioester biosynthetic process (GO:0035384)2.29951608
188acyl-CoA biosynthetic process (GO:0071616)2.29951608
189regulation of lipoprotein metabolic process (GO:0050746)2.28895517
190detection of bacterium (GO:0016045)2.28791068

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.05570493
2EGR1_23403033_ChIP-Seq_LIVER_Mouse3.66909083
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.47437968
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.38184066
5GATA1_22025678_ChIP-Seq_K562_Human3.00200052
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.93279820
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.84743975
8MYB_26560356_Chip-Seq_TH2_Human2.81155059
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.71822844
10* RXR_22158963_ChIP-Seq_LIVER_Mouse2.66807294
11TAF15_26573619_Chip-Seq_HEK293_Human2.63996828
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.62094594
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.48336291
14LXR_22158963_ChIP-Seq_LIVER_Mouse2.36438475
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.32415839
16FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.23006427
17SPI1_23547873_ChIP-Seq_NB4_Human2.18285859
18CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.18178975
19MYB_26560356_Chip-Seq_TH1_Human2.16878967
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.16822383
21* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.15894328
22Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.11356583
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.10189745
24* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.05376603
25* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.04944735
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.01027532
27GATA3_27048872_Chip-Seq_THYMUS_Human1.96552688
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94925630
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.93220305
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91701034
31GBX2_23144817_ChIP-Seq_PC3_Human1.91477572
32IRF8_27001747_Chip-Seq_BMDM_Mouse1.89829293
33MYB_21317192_ChIP-Seq_ERMYB_Mouse1.86435822
34CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.86153517
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.84651305
36SCL_19346495_ChIP-Seq_HPC-7_Human1.82630997
37NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.81913909
38NRF2_20460467_ChIP-Seq_MEFs_Mouse1.81913909
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81373393
40SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.71889871
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.69265162
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.67938898
43SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.65439216
44P300_19829295_ChIP-Seq_ESCs_Human1.58528280
45VDR_23849224_ChIP-Seq_CD4+_Human1.52212140
46* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.50838160
47HTT_18923047_ChIP-ChIP_STHdh_Human1.50532279
48MAF_26560356_Chip-Seq_TH1_Human1.49095326
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.47879412
50ER_23166858_ChIP-Seq_MCF-7_Human1.46852205
51RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.44413510
52PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.44035263
53NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.43262290
54VDR_22108803_ChIP-Seq_LS180_Human1.39686976
55CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.37865835
56CIITA_25753668_ChIP-Seq_RAJI_Human1.37682801
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.36836267
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.36341711
59RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.36321362
60RUNX_20019798_ChIP-Seq_JUKART_Human1.35098814
61STAT4_19710469_ChIP-ChIP_TH1__Mouse1.31607135
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30442665
63PU_27001747_Chip-Seq_BMDM_Mouse1.25968213
64STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.24741584
65FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.24551197
66HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22631163
67CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22201361
68ELK1_19687146_ChIP-ChIP_HELA_Human1.21402468
69SOX2_20726797_ChIP-Seq_SW620_Human1.20083910
70* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.19891675
71E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.19488681
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.18798033
73SMAD_19615063_ChIP-ChIP_OVARY_Human1.18740935
74VDR_24787735_ChIP-Seq_THP-1_Human1.18654971
75PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18618110
76SPI1_23127762_ChIP-Seq_K562_Human1.18468995
77EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14967836
78UTX_26944678_Chip-Seq_JUKART_Human1.12640197
79SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12190239
80RUNX1_22412390_ChIP-Seq_EML_Mouse1.11265602
81FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10794359
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10701108
83RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.10517464
84STAT3_18555785_Chip-Seq_ESCs_Mouse1.08788123
85AR_21572438_ChIP-Seq_LNCaP_Human1.08484225
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.08418200
87LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.08411483
88TAL1_26923725_Chip-Seq_HPCs_Mouse1.08286605
89EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08193330
90TP53_18474530_ChIP-ChIP_U2OS_Human1.08091312
91PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07875033
92GATA2_22383799_ChIP-Seq_G1ME_Mouse1.07192944
93P53_22387025_ChIP-Seq_ESCs_Mouse1.06458252
94CMYC_18555785_Chip-Seq_ESCs_Mouse1.06187079
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05999505
96RUNX1_27457419_Chip-Seq_LIVER_Mouse1.05991072
97EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05914239
98P300_18555785_Chip-Seq_ESCs_Mouse1.05713501
99GATA3_26560356_Chip-Seq_TH1_Human1.04335618
100WT1_19549856_ChIP-ChIP_CCG9911_Human1.03695128
101PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03337161
102NFE2_27457419_Chip-Seq_LIVER_Mouse1.03103829
103FOXP3_21729870_ChIP-Seq_TREG_Human1.02718623
104GABP_17652178_ChIP-ChIP_JURKAT_Human1.02635725
105PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02536235
106CRX_20693478_ChIP-Seq_RETINA_Mouse1.02139581
107CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01873367
108FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.01857725
109PRDM14_20953172_ChIP-Seq_ESCs_Human1.01311591
110SALL4_22934838_ChIP-ChIP_CD34+_Human1.00826241
111SMRT_27268052_Chip-Seq_Bcells_Human1.00147194
112SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00142408
113SOX2_19829295_ChIP-Seq_ESCs_Human0.99775791
114NANOG_19829295_ChIP-Seq_ESCs_Human0.99775791
115SOX2_18555785_Chip-Seq_ESCs_Mouse0.99760478
116PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.99285297
117TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99284464
118SMAD3_21741376_ChIP-Seq_EPCs_Human0.98580010
119VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97003720
120* SMAD1_18555785_Chip-Seq_ESCs_Mouse0.96928473
121CTBP2_25329375_ChIP-Seq_LNCAP_Human0.96912505
122RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96566141
123FUS_26573619_Chip-Seq_HEK293_Human0.96518346
124TFEB_21752829_ChIP-Seq_HELA_Human0.96270434
125E2F1_18555785_Chip-Seq_ESCs_Mouse0.95830476
126GATA3_26560356_Chip-Seq_TH2_Human0.94211525
127SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.94140165
128E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.93785598
129EWS_26573619_Chip-Seq_HEK293_Human0.93695700
130PU1_27457419_Chip-Seq_LIVER_Mouse0.93343076
131CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93182728
132MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.93037832
133NMYC_18555785_Chip-Seq_ESCs_Mouse0.92841365
134GATA2_21666600_ChIP-Seq_HMVEC_Human0.92513879
135CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.92373872
136PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91957727
137OCT4_18555785_Chip-Seq_ESCs_Mouse0.90848195
138NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.90536435
139EGR1_19032775_ChIP-ChIP_M12_Human0.90139998
140STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.89529975
141TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89205405
142EST1_17652178_ChIP-ChIP_JURKAT_Human0.88926320
143MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.88121485
144IGF1R_20145208_ChIP-Seq_DFB_Human0.87842386
145PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87145592
146OCT4_21477851_ChIP-Seq_ESCs_Mouse0.87097007
147LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.83718161
148FOXA1_21572438_ChIP-Seq_LNCaP_Human0.83506187
149MYC_22102868_ChIP-Seq_BL_Human0.83050640
150EGR1_19374776_ChIP-ChIP_THP-1_Human0.82622810
151VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.80395201
152GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.80034741
153IRF1_19129219_ChIP-ChIP_H3396_Human0.79603749
154ERG_20887958_ChIP-Seq_HPC-7_Mouse0.78865468
155MAF_26560356_Chip-Seq_TH2_Human0.78020718
156E2F4_17652178_ChIP-ChIP_JURKAT_Human0.77812520
157VDR_24763502_ChIP-Seq_THP-1_Human0.77154094
158NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.75813582

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.65040736
2MP0005360_urolithiasis3.56267272
3MP0008875_abnormal_xenobiotic_pharmacok3.56208413
4MP0003763_abnormal_thymus_physiology3.37728691
5MP0003724_increased_susceptibility_to3.32627415
6MP0005085_abnormal_gallbladder_physiolo3.18589300
7MP0002166_altered_tumor_susceptibility2.89263673
8MP0001835_abnormal_antigen_presentation2.72856703
9MP0003806_abnormal_nucleotide_metabolis2.63505227
10MP0009785_altered_susceptibility_to2.58926772
11MP0005365_abnormal_bile_salt2.57999128
12MP0000920_abnormal_myelination2.43973364
13MP0003690_abnormal_glial_cell2.43521319
14MP0006082_CNS_inflammation2.35578828
15MP0002006_tumorigenesis2.16713827
16MP0002009_preneoplasia2.16536871
17MP0005671_abnormal_response_to2.14510272
18MP0000604_amyloidosis2.07553308
19MP0002398_abnormal_bone_marrow2.07295833
20MP0002419_abnormal_innate_immunity2.04430599
21MP0003195_calcinosis2.02170292
22MP0002148_abnormal_hypersensitivity_rea1.97335457
23MP0009840_abnormal_foam_cell1.90737138
24MP0005058_abnormal_lysosome_morphology1.88519612
25MP0002132_abnormal_respiratory_system1.87980923
26MP0005025_abnormal_response_to1.87891359
27MP0003191_abnormal_cellular_cholesterol1.87539813
28MP0004147_increased_porphyrin_level1.87314749
29MP0000569_abnormal_digit_pigmentation1.86030066
30MP0005000_abnormal_immune_tolerance1.85639238
31MP0000689_abnormal_spleen_morphology1.84198424
32MP0009764_decreased_sensitivity_to1.83844718
33MP0008057_abnormal_DNA_replication1.83050034
34MP0003186_abnormal_redox_activity1.81324019
35MP0001790_abnormal_immune_system1.79494866
36MP0005387_immune_system_phenotype1.79494866
37MP0005075_abnormal_melanosome_morpholog1.79402237
38MP0003436_decreased_susceptibility_to1.75367082
39MP0010329_abnormal_lipoprotein_level1.73127151
40MP0003880_abnormal_central_pattern1.73027045
41MP0002722_abnormal_immune_system1.71238979
42MP0003300_gastrointestinal_ulcer1.69650426
43MP0009697_abnormal_copulation1.67651949
44MP0002396_abnormal_hematopoietic_system1.63877521
45MP0000703_abnormal_thymus_morphology1.61519737
46MP0002876_abnormal_thyroid_physiology1.60018717
47MP0003656_abnormal_erythrocyte_physiolo1.57262710
48MP0001873_stomach_inflammation1.57069294
49MP0005083_abnormal_biliary_tract1.56248905
50MP0002429_abnormal_blood_cell1.54473404
51MP0003866_abnormal_defecation1.52765906
52MP0005332_abnormal_amino_acid1.51204026
53MP0005451_abnormal_body_composition1.49634330
54MP0001666_abnormal_nutrient_absorption1.48578756
55MP0006054_spinal_hemorrhage1.47272592
56MP0002723_abnormal_immune_serum1.43400521
57MP0008469_abnormal_protein_level1.42737306
58MP0002452_abnormal_antigen_presenting1.40793497
59MP0004782_abnormal_surfactant_physiolog1.39717902
60MP0001800_abnormal_humoral_immune1.38794388
61MP0008260_abnormal_autophagy1.33897957
62MP0004381_abnormal_hair_follicle1.33101010
63MP0005464_abnormal_platelet_physiology1.30551725
64MP0000685_abnormal_immune_system1.29829597
65MP0003075_altered_response_to1.29481367
66MP0002254_reproductive_system_inflammat1.29099728
67MP0003950_abnormal_plasma_membrane1.28268885
68MP0005408_hypopigmentation1.27073210
69MP0001533_abnormal_skeleton_physiology1.26342423
70MP0001764_abnormal_homeostasis1.25803585
71MP0002118_abnormal_lipid_homeostasis1.24684887
72MP0001905_abnormal_dopamine_level1.21608244
73MP0003329_amyloid_beta_deposits1.20494428
74MP0005166_decreased_susceptibility_to1.18022482
75MP0002420_abnormal_adaptive_immunity1.17530250
76MP0003183_abnormal_peptide_metabolism1.17199860
77MP0001819_abnormal_immune_cell1.16300089
78MP0005164_abnormal_response_to1.16108165
79MP0005584_abnormal_enzyme/coenzyme_acti1.14137214
80MP0004947_skin_inflammation1.12205722
81MP0002405_respiratory_system_inflammati1.11808283
82MP0001851_eye_inflammation1.11721236
83MP0001845_abnormal_inflammatory_respons1.08750710
84MP0004019_abnormal_vitamin_homeostasis1.08678327
85MP0009763_increased_sensitivity_to1.05805814
86MP0000609_abnormal_liver_physiology1.01720033
87MP0003136_yellow_coat_color0.97500864
88MP0009765_abnormal_xenobiotic_induced0.95179447
89MP0009379_abnormal_foot_pigmentation0.93859566
90MP0003252_abnormal_bile_duct0.92413666
91MP0001529_abnormal_vocalization0.91841253
92MP0000015_abnormal_ear_pigmentation0.91489392
93MP0000858_altered_metastatic_potential0.91455854
94MP0002138_abnormal_hepatobiliary_system0.89112032
95MP0005319_abnormal_enzyme/_coenzyme0.88805345
96MP0010155_abnormal_intestine_physiology0.88241640
97MP0003172_abnormal_lysosome_physiology0.88196053
98MP0003786_premature_aging0.87392857
99MP0002019_abnormal_tumor_incidence0.86231328
100MP0003045_fibrosis0.85805069
101MP0003011_delayed_dark_adaptation0.85531888
102MP0003303_peritoneal_inflammation0.80493682
103MP0004808_abnormal_hematopoietic_stem0.79463948
104MP0001542_abnormal_bone_strength0.78932537
105MP0009333_abnormal_splenocyte_physiolog0.76460024
106MP0010307_abnormal_tumor_latency0.75567215
107MP0001501_abnormal_sleep_pattern0.75544529
108MP0000716_abnormal_immune_system0.75143155
109MP0004883_abnormal_blood_vessel0.74842900
110MP0003633_abnormal_nervous_system0.74722104
111MP0009643_abnormal_urine_homeostasis0.74596471
112MP0003448_altered_tumor_morphology0.74508196
113MP0002136_abnormal_kidney_physiology0.73623246
114MP0002277_abnormal_respiratory_mucosa0.73215852
115MP0005379_endocrine/exocrine_gland_phen0.72051779
116MP0004742_abnormal_vestibular_system0.71883839
117MP0000343_altered_response_to0.71399152
118MP0002933_joint_inflammation0.71103941
119MP0000465_gastrointestinal_hemorrhage0.70066655
120MP0003718_maternal_effect0.69920126
121MP0001853_heart_inflammation0.69638545
122MP0005636_abnormal_mineral_homeostasis0.69323471
123MP0000427_abnormal_hair_cycle0.68805795
124MP0003221_abnormal_cardiomyocyte_apopto0.68652974
125MP0003828_pulmonary_edema0.68486198
126MP0003868_abnormal_feces_composition0.68427691
127MP0005310_abnormal_salivary_gland0.68252525
128MP0005376_homeostasis/metabolism_phenot0.67445781
129MP0010234_abnormal_vibrissa_follicle0.67426083
130MP0002693_abnormal_pancreas_physiology0.67370790
131MP0002998_abnormal_bone_remodeling0.64646662
132MP0000371_diluted_coat_color0.64557294
133MP0008004_abnormal_stomach_pH0.62396150
134MP0002064_seizures0.62227367
135MP0000372_irregular_coat_pigmentation0.60869583
136MP0000249_abnormal_blood_vessel0.59888310
137MP0001661_extended_life_span0.59622189
138MP0010094_abnormal_chromosome_stability0.59414926
139MP0006035_abnormal_mitochondrial_morpho0.58386730

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)4.52465928
2Intrahepatic cholestasis (HP:0001406)4.16035788
3Abnormality of aromatic amino acid family metabolism (HP:0004338)4.14913110
4Prolonged partial thromboplastin time (HP:0003645)3.99083067
5Abnormal delayed hypersensitivity skin test (HP:0002963)3.89245730
6Recurrent fungal infections (HP:0002841)3.82941627
7Panhypogammaglobulinemia (HP:0003139)3.82548457
8Recurrent viral infections (HP:0004429)3.81137015
9Meningitis (HP:0001287)3.78514065
10IgM deficiency (HP:0002850)3.77971519
11Abnormality of T cells (HP:0002843)3.72415955
12Parakeratosis (HP:0001036)3.69571703
13IgG deficiency (HP:0004315)3.67258005
14Recurrent bronchitis (HP:0002837)3.62224830
15Recurrent cutaneous fungal infections (HP:0011370)3.58113186
16Chronic mucocutaneous candidiasis (HP:0002728)3.58113186
17Agammaglobulinemia (HP:0004432)3.57998579
18Abnormality of B cell number (HP:0010975)3.51463785
19Mediastinal lymphadenopathy (HP:0100721)3.43832849
20Chronic diarrhea (HP:0002028)3.39750907
21Autoimmune thrombocytopenia (HP:0001973)3.37494375
22Abnormality of the prostate (HP:0008775)3.36416804
23Xanthomatosis (HP:0000991)3.31928898
24B lymphocytopenia (HP:0010976)3.29307070
25Encephalitis (HP:0002383)3.24029456
26Severe combined immunodeficiency (HP:0004430)3.21285685
27Abnormality of T cell physiology (HP:0011840)3.21132719
28Neurofibrillary tangles (HP:0002185)3.19738218
29Hypobetalipoproteinemia (HP:0003563)3.19628082
30Hyperlipoproteinemia (HP:0010980)3.18195055
31Recurrent gram-negative bacterial infections (HP:0005420)3.13387690
32Vacuolated lymphocytes (HP:0001922)3.11215141
33Gastrointestinal infarctions (HP:0005244)3.08148405
34Deep venous thrombosis (HP:0002625)3.07980141
35Recurrent sinusitis (HP:0011108)3.05484036
36Lymphopenia (HP:0001888)3.02808476
37IgA deficiency (HP:0002720)2.99976277
38Thyroiditis (HP:0100646)2.99940110
39Pulmonary infiltrates (HP:0002113)2.91548989
40Joint hemorrhage (HP:0005261)2.89000505
41Recurrent abscess formation (HP:0002722)2.87689674
42Pustule (HP:0200039)2.86518205
43Conjugated hyperbilirubinemia (HP:0002908)2.86123433
44Abnormality of macrophages (HP:0004311)2.85402272
45Hemoptysis (HP:0002105)2.82830189
46Renal Fanconi syndrome (HP:0001994)2.82666840
47Hepatosplenomegaly (HP:0001433)2.82462109
48Fat malabsorption (HP:0002630)2.81080603
49Recurrent bacterial skin infections (HP:0005406)2.80278887
50Abnormality of cells of the lymphoid lineage (HP:0012140)2.80183064
51Complement deficiency (HP:0004431)2.76490049
52Combined immunodeficiency (HP:0005387)2.75541551
53Eosinophilia (HP:0001880)2.75379352
54Acanthocytosis (HP:0001927)2.74945100
55Steatorrhea (HP:0002570)2.72514760
56Degeneration of the lateral corticospinal tracts (HP:0002314)2.70476639
57Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.70476639
58Colitis (HP:0002583)2.69026243
59Granulocytopenia (HP:0001913)2.67090167
60Stomatitis (HP:0010280)2.66414868
61Systemic lupus erythematosus (HP:0002725)2.61798704
62Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.60815776
63Gastrointestinal stroma tumor (HP:0100723)2.60417075
64Eczematoid dermatitis (HP:0000976)2.59164524
65Chronic obstructive pulmonary disease (HP:0006510)2.58333174
66Obstructive lung disease (HP:0006536)2.58333174
67Inflammation of the large intestine (HP:0002037)2.57654039
68Abnormality of eosinophils (HP:0001879)2.56929639
69Axonal loss (HP:0003447)2.52089567
70Abnormality of monocarboxylic acid metabolism (HP:0010996)2.46118290
71Increased serum pyruvate (HP:0003542)2.44094211
72Abnormality of glycolysis (HP:0004366)2.44094211
73Leukocytosis (HP:0001974)2.42926419
74Chest pain (HP:0100749)2.42326580
75Spontaneous abortion (HP:0005268)2.41482525
76Hematochezia (HP:0002573)2.39083516
77Lymphoma (HP:0002665)2.36446856
78Purpura (HP:0000979)2.35201906
79Bronchitis (HP:0012387)2.34296720
80Congenital ichthyosiform erythroderma (HP:0007431)2.32588335
81Gastrointestinal inflammation (HP:0004386)2.32049324
82Acute encephalopathy (HP:0006846)2.30071668
83Abnormality of methionine metabolism (HP:0010901)2.28982502
84Abnormality of the common coagulation pathway (HP:0010990)2.27264730
85Acute necrotizing encephalopathy (HP:0006965)2.27042806
86Sensory axonal neuropathy (HP:0003390)2.26991096
87Amyloidosis (HP:0011034)2.26638935
88Spontaneous hematomas (HP:0007420)2.26484311
89Increased hepatocellular lipid droplets (HP:0006565)2.25713010
90Abnormality of aspartate family amino acid metabolism (HP:0010899)2.25173764
91Cerebral hemorrhage (HP:0001342)2.24871736
92Prostate neoplasm (HP:0100787)2.24048949
93Abnormality of the heme biosynthetic pathway (HP:0010472)2.23669151
94Viral hepatitis (HP:0006562)2.23116876
95Arterial thrombosis (HP:0004420)2.21978813
96Glomerulonephritis (HP:0000099)2.21505721
97Lipid accumulation in hepatocytes (HP:0006561)2.20387764
98Abnormality of renal resorption (HP:0011038)2.20123858
99Recurrent pneumonia (HP:0006532)2.19923074
100Cellulitis (HP:0100658)2.18860067
101Hypoproteinemia (HP:0003075)2.18738497
102Osteomyelitis (HP:0002754)2.18666865
103Recurrent skin infections (HP:0001581)2.18376578
104Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.16916583
105Verrucae (HP:0200043)2.16788975
106Papilloma (HP:0012740)2.16788975
107Fair hair (HP:0002286)2.16709827
108Cerebral edema (HP:0002181)2.15838550
109Increased IgE level (HP:0003212)2.15257489
110Abnormality of complement system (HP:0005339)2.12692170
111Mitochondrial inheritance (HP:0001427)2.11016394
112Gingival bleeding (HP:0000225)2.10799356
113Abnormality of the pleura (HP:0002103)2.09909408
114Fatigue (HP:0012378)2.09862933
115Abnormality of liposaccharide metabolism (HP:0010968)2.09595827
116Abnormality of glycosphingolipid metabolism (HP:0004343)2.09595827
117Abnormality of glycolipid metabolism (HP:0010969)2.09595827
118Autoamputation (HP:0001218)2.08455594
119Acute hepatic failure (HP:0006554)2.06735157
120Gingivitis (HP:0000230)2.05937371
121Anorexia (HP:0002039)2.05814767
122Urticaria (HP:0001025)2.05033964
123Epidermoid cyst (HP:0200040)2.04231605
124Cerebral inclusion bodies (HP:0100314)2.03762699
125Skin rash (HP:0000988)2.02529927
126Elevated erythrocyte sedimentation rate (HP:0003565)2.02521565
127Abnormality of male internal genitalia (HP:0000022)2.01794483
128Retrobulbar optic neuritis (HP:0100654)2.00940141
129Optic neuritis (HP:0100653)2.00940141
130Hypolipoproteinemia (HP:0010981)2.00870135
131Chronic otitis media (HP:0000389)1.98437095
132Hypophosphatemic rickets (HP:0004912)1.97435266
133Abnormality of glutamine family amino acid metabolism (HP:0010902)1.94939328
134Keratoconjunctivitis sicca (HP:0001097)1.94764851
135Recurrent lower respiratory tract infections (HP:0002783)1.94695001
136Bronchiectasis (HP:0002110)1.92985268
137Prolonged neonatal jaundice (HP:0006579)1.91110810
138Abnormal mitochondria in muscle tissue (HP:0008316)1.90768251
139Hypercholesterolemia (HP:0003124)1.89745101
140Joint swelling (HP:0001386)1.89395883
141Pulmonary embolism (HP:0002204)1.87841803
142Polyneuropathy (HP:0001271)1.87580557
143Spastic paraparesis (HP:0002313)1.87027138
144Increased neuronal autofluorescent lipopigment (HP:0002074)1.86447675
145Keratoconjunctivitis (HP:0001096)1.86353127
146Orchitis (HP:0100796)1.85661762
147Hypoplasia of the thymus (HP:0000778)1.85468401
148Vasculitis (HP:0002633)1.85070696
149Abnormality of urine glucose concentration (HP:0011016)1.84267923
150Glycosuria (HP:0003076)1.84267923
1513-Methylglutaconic aciduria (HP:0003535)1.84141625
152Amaurosis fugax (HP:0100576)1.84121106
153Slow saccadic eye movements (HP:0000514)1.84031140
154Progressive macrocephaly (HP:0004481)1.83818723
155Keratitis (HP:0000491)1.83659817
156Increased CSF lactate (HP:0002490)1.83441324
157Basal cell carcinoma (HP:0002671)1.82956692
158Abnormality of fatty-acid metabolism (HP:0004359)1.82068501
159Premature loss of primary teeth (HP:0006323)1.81281418
160Increased cerebral lipofuscin (HP:0011813)1.81195594
161Leukodystrophy (HP:0002415)1.81125920
162Gangrene (HP:0100758)1.80500480
163Autoimmune hemolytic anemia (HP:0001890)1.80414169
164Vascular calcification (HP:0004934)1.78488857
165Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.77918740
166Hepatocellular necrosis (HP:0001404)1.76272502
167Erythroderma (HP:0001019)1.75214509
168Myositis (HP:0100614)1.74461387
169Abnormality of the corticospinal tract (HP:0002492)1.70487822
170Abnormality of sulfur amino acid metabolism (HP:0004339)1.70399558
171Hepatic necrosis (HP:0002605)1.70134924
172Hyperbilirubinemia (HP:0002904)1.69991967
173Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.69188260
174Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.67898834
175Abnormality of the lumbar spine (HP:0100712)1.66789991
176Abnormality of the axillary hair (HP:0100134)1.64916208
177Abnormality of secondary sexual hair (HP:0009888)1.64916208
178Increased IgM level (HP:0003496)1.64722452
179Abnormality of T cell number (HP:0011839)1.63711159
180Abnormality of iron homeostasis (HP:0011031)1.62945084

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK3.80016368
2MST43.20631825
3STK392.98284884
4EIF2AK32.91024845
5CASK2.89429648
6OXSR12.73778799
7MAP3K142.67121695
8FRK2.56428184
9BLK2.21742990
10GRK72.14672636
11TXK2.09221792
12EPHB12.05492040
13BMPR22.03159206
14RIPK42.01046386
15CAMKK21.94799629
16GRK61.75138065
17IKBKE1.63433738
18FGR1.62641246
19BCR1.59891840
20TBK11.50591568
21IRAK41.44624567
22TNIK1.42251622
23CDK191.40302349
24TYK21.38759575
25MAP3K121.37026518
26JAK31.36446510
27MUSK1.35781539
28MAPKAPK51.35591016
29ACVR1B1.34513466
30BMPR1B1.33881396
31MARK31.29765000
32ITK1.26737443
33EPHA31.26358309
34BRD41.23335134
35HCK1.23312567
36PKN11.20754450
37TEC1.18019679
38IKBKB1.17090504
39MAP3K131.16935090
40IRAK31.14226203
41FGFR31.09961047
42PIK3CA1.09521174
43PRKCQ1.08397416
44TAOK31.06934853
45MET1.06840419
46ARAF1.04609428
47ADRBK21.02621411
48PIM11.00124769
49MST1R1.00089160
50ERBB40.99246629
51MAP4K10.98732740
52STK100.96177138
53STK240.94850887
54CLK10.94077540
55LCK0.93040779
56MAP2K70.92144816
57KIT0.91708165
58MOS0.89871084
59NUAK10.87091532
60CDK60.86790013
61SYK0.86694472
62TGFBR20.85731303
63SIK30.85225282
64CSK0.84081998
65STK38L0.83499720
66LYN0.83115222
67CAMK2B0.81081258
68ABL20.80920470
69MAP3K30.80445895
70MAPK110.80416012
71SGK4940.80129538
72SGK2230.80129538
73NEK60.79785883
74GRK10.79695001
75BRSK20.77903091
76GRK50.77597880
77ERBB30.75833827
78FES0.74489555
79MAPK150.72768548
80PIM20.71489084
81FGFR40.69796312
82TRPM70.69487470
83CAMK2G0.69149045
84JAK10.68606383
85CAMK2A0.68388731
86STK160.66424401
87MAP4K20.66116424
88EIF2AK10.65682523
89MYLK0.65596637
90BTK0.65463261
91EPHA40.64783013
92MAP3K20.62927795
93PLK20.62827354
94ZAK0.62822447
95IRAK10.61892206
96PRKCE0.61652628
97DAPK20.59954030
98PRKCD0.59144927
99PRPF4B0.58362394
100MATK0.57271039
101CCNB10.57202375
102PDK10.56911584
103NME10.56807670
104CAMK2D0.56626091
105MAP2K40.56170062
106NLK0.55741509
107CSF1R0.55510243
108CSNK1G30.54592932
109SCYL20.53237860
110JAK20.52366984
111MAPK70.52182486
112IRAK20.52134142
113NME20.51906740
114IGF1R0.51782658
115PIK3CG0.51432283
116YES10.51409087
117ZAP700.50012564
118FYN0.49482208
119ADRBK10.49201233
120TNK20.49154022
121SIK10.48292672
122BCKDK0.47908113
123ABL10.47355601
124PASK0.47353461
125CDK40.47296792
126ROCK20.46963108
127TIE10.46634710
128MAPK40.46047556
129NEK90.45978511
130EGFR0.45496647
131SRPK10.45117253
132VRK10.43021669
133MAP2K30.42871104
134CAMKK10.42001566
135EIF2AK20.41753829
136MAP2K60.38592160
137TLK10.37704846
138MAP3K50.36042490
139CHUK0.33293624
140RPS6KA40.33249472
141SGK20.32218464
142AKT30.31077716
143MKNK10.30821703
144RPS6KA50.28961249
145INSR0.28184944
146PRKAA20.26980565
147PDK20.26906303

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001003.42227019
2Type I diabetes mellitus_Homo sapiens_hsa049403.22019582
3Antigen processing and presentation_Homo sapiens_hsa046122.99757276
4Fatty acid elongation_Homo sapiens_hsa000622.97484738
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.92855647
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.79003721
7Histidine metabolism_Homo sapiens_hsa003402.49925891
8Sulfur metabolism_Homo sapiens_hsa009202.45446562
9Staphylococcus aureus infection_Homo sapiens_hsa051502.39948640
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.29559762
11Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.26196920
12Complement and coagulation cascades_Homo sapiens_hsa046102.17132595
13B cell receptor signaling pathway_Homo sapiens_hsa046622.11844595
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.01931311
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.97809142
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.96730014
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.95738586
18Viral myocarditis_Homo sapiens_hsa054161.90926885
19Peroxisome_Homo sapiens_hsa041461.89619563
20Caffeine metabolism_Homo sapiens_hsa002321.88004663
21Osteoclast differentiation_Homo sapiens_hsa043801.86908272
22Chemical carcinogenesis_Homo sapiens_hsa052041.84740477
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.84290383
24T cell receptor signaling pathway_Homo sapiens_hsa046601.83380044
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.71673080
26Oxidative phosphorylation_Homo sapiens_hsa001901.64223401
27Herpes simplex infection_Homo sapiens_hsa051681.62439759
28Graft-versus-host disease_Homo sapiens_hsa053321.61091960
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.59590704
30Retinol metabolism_Homo sapiens_hsa008301.53677306
31Rheumatoid arthritis_Homo sapiens_hsa053231.53410549
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.51043881
33Toxoplasmosis_Homo sapiens_hsa051451.46819044
34Butanoate metabolism_Homo sapiens_hsa006501.45501891
35Arginine biosynthesis_Homo sapiens_hsa002201.45359281
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44641117
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.43064293
38Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.35504706
39Influenza A_Homo sapiens_hsa051641.33638641
40Tryptophan metabolism_Homo sapiens_hsa003801.33113279
41Systemic lupus erythematosus_Homo sapiens_hsa053221.32872141
42* Ether lipid metabolism_Homo sapiens_hsa005651.32200981
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.31399828
44Allograft rejection_Homo sapiens_hsa053301.25847310
45Jak-STAT signaling pathway_Homo sapiens_hsa046301.25301764
46Protein export_Homo sapiens_hsa030601.24990887
47Fatty acid metabolism_Homo sapiens_hsa012121.23528454
48beta-Alanine metabolism_Homo sapiens_hsa004101.23353194
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.23294227
50Fatty acid degradation_Homo sapiens_hsa000711.21868221
51Phenylalanine metabolism_Homo sapiens_hsa003601.16451410
52Folate biosynthesis_Homo sapiens_hsa007901.15119936
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14112701
54Tyrosine metabolism_Homo sapiens_hsa003501.07862671
55PPAR signaling pathway_Homo sapiens_hsa033201.07605214
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.06446918
57Malaria_Homo sapiens_hsa051441.03551331
58Collecting duct acid secretion_Homo sapiens_hsa049661.01983015
59Propanoate metabolism_Homo sapiens_hsa006401.00259308
60Sphingolipid metabolism_Homo sapiens_hsa006000.99509514
61Phagosome_Homo sapiens_hsa041450.95947734
62Pertussis_Homo sapiens_hsa051330.95602024
63Chemokine signaling pathway_Homo sapiens_hsa040620.94752049
64Nitrogen metabolism_Homo sapiens_hsa009100.94538394
65TNF signaling pathway_Homo sapiens_hsa046680.91569315
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.91561431
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.91390878
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90351556
69Glutathione metabolism_Homo sapiens_hsa004800.89046329
70Alzheimers disease_Homo sapiens_hsa050100.88468834
71Intestinal immune network for IgA production_Homo sapiens_hsa046720.86429191
72Non-homologous end-joining_Homo sapiens_hsa034500.85590855
73Parkinsons disease_Homo sapiens_hsa050120.85419534
74Arginine and proline metabolism_Homo sapiens_hsa003300.84258526
75Autoimmune thyroid disease_Homo sapiens_hsa053200.84255251
76Vitamin digestion and absorption_Homo sapiens_hsa049770.83860064
77African trypanosomiasis_Homo sapiens_hsa051430.83487886
78Hepatitis B_Homo sapiens_hsa051610.83274613
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83059271
80Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.81391009
81NOD-like receptor signaling pathway_Homo sapiens_hsa046210.80809531
82Epstein-Barr virus infection_Homo sapiens_hsa051690.79379267
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78167554
84Linoleic acid metabolism_Homo sapiens_hsa005910.77882574
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76389125
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.75930516
87Apoptosis_Homo sapiens_hsa042100.73128330
88Lysosome_Homo sapiens_hsa041420.72369451
89Pyruvate metabolism_Homo sapiens_hsa006200.70608796
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70541005
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70454903
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70128052
93ABC transporters_Homo sapiens_hsa020100.70105187
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67939009
95Legionellosis_Homo sapiens_hsa051340.67623733
96Leishmaniasis_Homo sapiens_hsa051400.66740455
97Platelet activation_Homo sapiens_hsa046110.66257444
98Hematopoietic cell lineage_Homo sapiens_hsa046400.65751838
99Viral carcinogenesis_Homo sapiens_hsa052030.64660751
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64549701
101Other glycan degradation_Homo sapiens_hsa005110.63558100
102Hepatitis C_Homo sapiens_hsa051600.60935331
103Arachidonic acid metabolism_Homo sapiens_hsa005900.58865357
104Starch and sucrose metabolism_Homo sapiens_hsa005000.58558506
105Primary immunodeficiency_Homo sapiens_hsa053400.57915923
106Toll-like receptor signaling pathway_Homo sapiens_hsa046200.57873072
107Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.57682694
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57532697
109Bile secretion_Homo sapiens_hsa049760.56848989
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56017492
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55292887
112* Metabolic pathways_Homo sapiens_hsa011000.54367023
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53706090
114Proteasome_Homo sapiens_hsa030500.53197645
115Fat digestion and absorption_Homo sapiens_hsa049750.51631461
116Leukocyte transendothelial migration_Homo sapiens_hsa046700.50996797
117Acute myeloid leukemia_Homo sapiens_hsa052210.50648789
118NF-kappa B signaling pathway_Homo sapiens_hsa040640.49533044
119Asthma_Homo sapiens_hsa053100.47813393
120HTLV-I infection_Homo sapiens_hsa051660.46747490
121Sulfur relay system_Homo sapiens_hsa041220.45829076
122Salmonella infection_Homo sapiens_hsa051320.45774515
123Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44943499
124Vitamin B6 metabolism_Homo sapiens_hsa007500.43875316
125Selenocompound metabolism_Homo sapiens_hsa004500.43865888
126Cysteine and methionine metabolism_Homo sapiens_hsa002700.43268027
127Shigellosis_Homo sapiens_hsa051310.43008657
128RNA degradation_Homo sapiens_hsa030180.41791799
129Tuberculosis_Homo sapiens_hsa051520.41041211
130Regulation of autophagy_Homo sapiens_hsa041400.40000481
131Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38129436
132Vibrio cholerae infection_Homo sapiens_hsa051100.38008093
133p53 signaling pathway_Homo sapiens_hsa041150.37197718
134Measles_Homo sapiens_hsa051620.36388492
135Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.36140172
136Homologous recombination_Homo sapiens_hsa034400.34032737
137Inositol phosphate metabolism_Homo sapiens_hsa005620.33296181
138Renin-angiotensin system_Homo sapiens_hsa046140.32287486
139Sphingolipid signaling pathway_Homo sapiens_hsa040710.27410453
140Non-small cell lung cancer_Homo sapiens_hsa052230.26459567
141Carbohydrate digestion and absorption_Homo sapiens_hsa049730.26012492
142Glycerolipid metabolism_Homo sapiens_hsa005610.25520717
143Adipocytokine signaling pathway_Homo sapiens_hsa049200.21903644
144Prolactin signaling pathway_Homo sapiens_hsa049170.21156461
145Pancreatic cancer_Homo sapiens_hsa052120.20182447
146* Glycerophospholipid metabolism_Homo sapiens_hsa005640.18278891
147Insulin resistance_Homo sapiens_hsa049310.14859988
148Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.12502310
149FoxO signaling pathway_Homo sapiens_hsa040680.12209168

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