CERCAM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)7.12267921
2glutamate secretion (GO:0014047)6.06150719
3synaptic vesicle maturation (GO:0016188)5.71966117
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.15353332
5synaptic vesicle exocytosis (GO:0016079)5.00622478
6cellular potassium ion homeostasis (GO:0030007)4.68188321
7bone trabecula formation (GO:0060346)4.54607784
8sodium ion export (GO:0071436)4.54265102
9protein heterotrimerization (GO:0070208)4.35529247
10collagen fibril organization (GO:0030199)4.29713898
11regulation of synaptic vesicle exocytosis (GO:2000300)4.25520992
12L-amino acid import (GO:0043092)4.21359205
13amino acid import (GO:0043090)4.17772291
14negative regulation of synaptic transmission, GABAergic (GO:0032229)4.09722812
15neuronal ion channel clustering (GO:0045161)4.00045253
16membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.90937945
17regulation of neuronal synaptic plasticity (GO:0048168)3.86262658
18positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.82094125
19neurotransmitter secretion (GO:0007269)3.79682499
20locomotory exploration behavior (GO:0035641)3.77233808
21regulation of synaptic vesicle transport (GO:1902803)3.73320225
22kinetochore assembly (GO:0051382)3.61291235
23keratan sulfate catabolic process (GO:0042340)3.60978122
24myelin maintenance (GO:0043217)3.58314366
25DNA deamination (GO:0045006)3.45382740
26postsynaptic membrane organization (GO:0001941)3.42450688
27kinetochore organization (GO:0051383)3.38298089
28cerebellar granule cell differentiation (GO:0021707)3.37817974
29positive regulation of synapse maturation (GO:0090129)3.37764047
30positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.36961147
31neuronal action potential propagation (GO:0019227)3.35903466
32cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.34425591
33potassium ion homeostasis (GO:0055075)3.33504937
34regulation of long-term neuronal synaptic plasticity (GO:0048169)3.31213177
35extracellular fibril organization (GO:0043206)3.30198206
36cytoskeletal anchoring at plasma membrane (GO:0007016)3.26822580
37protoporphyrinogen IX metabolic process (GO:0046501)3.23152850
38cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.22981845
39response to gravity (GO:0009629)3.19375228
40fibril organization (GO:0097435)3.18165869
41heme biosynthetic process (GO:0006783)3.13169233
42astrocyte development (GO:0014002)3.12891449
43regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.12707901
44neuromuscular process controlling balance (GO:0050885)3.10154707
45vocalization behavior (GO:0071625)3.09474154
46protoporphyrinogen IX biosynthetic process (GO:0006782)3.08926553
47potassium ion import (GO:0010107)3.07763988
48chondrocyte development (GO:0002063)3.06003874
49collagen catabolic process (GO:0030574)3.04677227
50regulation of synaptic plasticity (GO:0048167)3.04444294
51exploration behavior (GO:0035640)2.98323010
52ensheathment of neurons (GO:0007272)2.97674708
53axon ensheathment (GO:0008366)2.97674708
54cell communication by electrical coupling (GO:0010644)2.97469098
55acidic amino acid transport (GO:0015800)2.97351631
56neurotransmitter transport (GO:0006836)2.97109406
57telomere maintenance via semi-conservative replication (GO:0032201)2.95846530
58cerebellar Purkinje cell layer development (GO:0021680)2.93996697
59collagen metabolic process (GO:0032963)2.93881660
60synaptic vesicle endocytosis (GO:0048488)2.93661066
61type B pancreatic cell proliferation (GO:0044342)2.92945225
62positive regulation of dendritic spine development (GO:0060999)2.90893534
63regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.90229595
64myelination (GO:0042552)2.88170661
65ionotropic glutamate receptor signaling pathway (GO:0035235)2.87549178
66positive regulation of DNA-dependent DNA replication (GO:2000105)2.86887218
67protein retention in ER lumen (GO:0006621)2.86185398
68protein targeting to plasma membrane (GO:0072661)2.79302905
69cartilage condensation (GO:0001502)2.77192226
70cell aggregation (GO:0098743)2.77192226
71dermatan sulfate biosynthetic process (GO:0030208)2.76506164
72superoxide anion generation (GO:0042554)2.75332982
73sequestering of extracellular ligand from receptor (GO:0035581)2.73785251
74regulation of neurotransmitter secretion (GO:0046928)2.73425374
75regulation of ARF protein signal transduction (GO:0032012)2.72929882
76regulation of neurotransmitter levels (GO:0001505)2.72658023
77regulation of nuclear cell cycle DNA replication (GO:0033262)2.72542119
78regulation of glutamate receptor signaling pathway (GO:1900449)2.71786906
79L-glutamate transport (GO:0015813)2.69976962
80adhesion of symbiont to host cell (GO:0044650)2.66846847
81virion attachment to host cell (GO:0019062)2.66846847
82multicellular organismal catabolic process (GO:0044243)2.66578861
83synaptic transmission, glutamatergic (GO:0035249)2.65817139
84regulation of synapse structural plasticity (GO:0051823)2.64268424
85positive regulation of membrane potential (GO:0045838)2.63623302
86protein localization to synapse (GO:0035418)2.63474769
87dermatan sulfate metabolic process (GO:0030205)2.63011716
88regulation of neurotransmitter transport (GO:0051588)2.62940336
89regulation of voltage-gated calcium channel activity (GO:1901385)2.62723534
90multicellular organismal macromolecule metabolic process (GO:0044259)2.62156470
91regulation of synapse maturation (GO:0090128)2.61989172
92regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.60748410
93ribosomal small subunit assembly (GO:0000028)2.59346165
94chondroitin sulfate catabolic process (GO:0030207)2.58699394
95maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.56619757
96regulation of excitatory postsynaptic membrane potential (GO:0060079)2.55957924
97blood vessel maturation (GO:0001955)2.54431650
98positive regulation of dendrite development (GO:1900006)2.54112908
99positive regulation of neurotransmitter transport (GO:0051590)2.53974003
100negative regulation of axonogenesis (GO:0050771)2.53873137
101negative regulation of myoblast differentiation (GO:0045662)2.53430327
102astrocyte differentiation (GO:0048708)2.53107655
103telomere maintenance via recombination (GO:0000722)2.52922726
104positive regulation of osteoblast proliferation (GO:0033690)2.52696975
105skin morphogenesis (GO:0043589)2.52602545
106substantia nigra development (GO:0021762)2.50853706
107neurotransmitter uptake (GO:0001504)2.50832879
108G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.50758449
109chondrocyte proliferation (GO:0035988)2.49056155
110limb bud formation (GO:0060174)2.48640319
111vesicle docking involved in exocytosis (GO:0006904)2.47971382
112neuromuscular process controlling posture (GO:0050884)2.47351858
113positive regulation of fibroblast migration (GO:0010763)2.46490908
114positive regulation of axon extension (GO:0045773)2.46279290
115positive regulation of neurotransmitter secretion (GO:0001956)2.45302423
116long-term synaptic potentiation (GO:0060291)2.45214905
117activation of protein kinase A activity (GO:0034199)2.45059459
118regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.44766878
119DNA strand elongation (GO:0022616)2.44668311
120regulation of male gonad development (GO:2000018)2.44395239
121regulation of synaptic transmission (GO:0050804)2.43739762
122DNA strand elongation involved in DNA replication (GO:0006271)2.43688755
123cell migration in hindbrain (GO:0021535)2.43476264
124regulation of vesicle fusion (GO:0031338)2.42486848
125dicarboxylic acid transport (GO:0006835)2.42076711
126positive regulation of male gonad development (GO:2000020)2.41315008
127endodermal cell differentiation (GO:0035987)2.41030717
128gamma-aminobutyric acid signaling pathway (GO:0007214)2.40064934
129multicellular organismal metabolic process (GO:0044236)2.38574714
130porphyrin-containing compound biosynthetic process (GO:0006779)2.36447177
131DNA replication initiation (GO:0006270)2.36173935
132positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.34054200
133positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.32997175
134erythrocyte development (GO:0048821)2.31945789
135modulation by virus of host process (GO:0019054)2.28321557
136notochord development (GO:0030903)2.28022537
137mitotic recombination (GO:0006312)2.27943461
138regulation of osteoblast proliferation (GO:0033688)2.26778871
139regulation of non-canonical Wnt signaling pathway (GO:2000050)2.26703324
140maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.26229624
141extracellular matrix disassembly (GO:0022617)2.25897264
142cellular response to ionizing radiation (GO:0071479)2.25072056
143phagocytosis, engulfment (GO:0006911)2.24963570
144bone remodeling (GO:0046849)2.24103066
145heme metabolic process (GO:0042168)2.23237342
146cranial suture morphogenesis (GO:0060363)2.22746872
147definitive hemopoiesis (GO:0060216)2.20760245
148meiotic chromosome segregation (GO:0045132)2.20734147
149myelin assembly (GO:0032288)2.20730238
150tetrapyrrole biosynthetic process (GO:0033014)2.19327970
151lateral sprouting from an epithelium (GO:0060601)2.18871483
152DNA replication checkpoint (GO:0000076)2.18419624
153erythrocyte maturation (GO:0043249)2.18413986
154neutrophil activation involved in immune response (GO:0002283)2.18407291
155DNA integration (GO:0015074)2.18132322
156proteasome assembly (GO:0043248)2.17264594
157chondroitin sulfate biosynthetic process (GO:0030206)2.16853429
158telomere maintenance via telomere lengthening (GO:0010833)2.15859750
159negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.14953350
160iron ion import (GO:0097286)2.13284985
161negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.13030910
162regulation of double-strand break repair via homologous recombination (GO:0010569)2.12957903
163regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.12600718
164nucleotide-excision repair, DNA gap filling (GO:0006297)2.11864551
165extracellular matrix assembly (GO:0085029)2.11843039
166extracellular negative regulation of signal transduction (GO:1900116)2.11614803
167extracellular regulation of signal transduction (GO:1900115)2.11614803
168replication fork processing (GO:0031297)2.11579681
169cell proliferation involved in kidney development (GO:0072111)2.11542724
170energy homeostasis (GO:0097009)2.11444052
171craniofacial suture morphogenesis (GO:0097094)2.10466227
172protein trimerization (GO:0070206)2.10228040
173CENP-A containing nucleosome assembly (GO:0034080)2.09820971
174response to lead ion (GO:0010288)2.09544354
175positive regulation of odontogenesis (GO:0042482)2.08660713
176central nervous system myelination (GO:0022010)2.07720968
177axon ensheathment in central nervous system (GO:0032291)2.07720968
178DNA ligation (GO:0006266)2.04818120
179glomerular basement membrane development (GO:0032836)2.04255332
180regulation of interleukin-8 secretion (GO:2000482)2.03804939
181negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.03682596
182mesenchymal-epithelial cell signaling (GO:0060638)2.03128731
183peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.01771412
184extracellular matrix organization (GO:0030198)2.00808501
185regulation of execution phase of apoptosis (GO:1900117)2.00462139
186extracellular structure organization (GO:0043062)2.00076892
187hyaluronan catabolic process (GO:0030214)1.99752652
188positive regulation of developmental pigmentation (GO:0048087)1.98651586
189regulation of T cell migration (GO:2000404)1.97506170

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.27690575
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.29996275
3PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.67475637
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.12921782
5THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.06638850
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.84710050
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.83054707
8EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.80210509
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.76834298
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.72240186
11MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.70049228
12EZH2_22144423_ChIP-Seq_EOC_Human2.66443288
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.61279288
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.61279288
15DROSHA_22980978_ChIP-Seq_HELA_Human2.61236374
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.60862161
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.57145930
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.56254754
19SCL_19346495_ChIP-Seq_HPC-7_Human2.56138516
20TP63_19390658_ChIP-ChIP_HaCaT_Human2.51828529
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.46077164
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.45345293
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.45227871
24BP1_19119308_ChIP-ChIP_Hs578T_Human2.43849797
25JARID2_20064375_ChIP-Seq_MESCs_Mouse2.39055123
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.36245358
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.34934400
28RNF2_27304074_Chip-Seq_ESCs_Mouse2.30610955
29MYC_18555785_ChIP-Seq_MESCs_Mouse2.28701327
30FOXM1_23109430_ChIP-Seq_U2OS_Human2.27076704
31EZH2_27294783_Chip-Seq_ESCs_Mouse2.26801822
32SUZ12_27294783_Chip-Seq_ESCs_Mouse2.22595484
33EZH2_27304074_Chip-Seq_ESCs_Mouse2.16591806
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.14370930
35RARB_27405468_Chip-Seq_BRAIN_Mouse2.06707783
36ESR2_21235772_ChIP-Seq_MCF-7_Human2.05352240
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.00339907
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.97782619
39FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.96235777
40LXR_22292898_ChIP-Seq_THP-1_Human1.88569487
41POU5F1_16153702_ChIP-ChIP_HESCs_Human1.87196932
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.83965575
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.83051473
44* KDM2B_26808549_Chip-Seq_K562_Human1.82658299
45WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.79987204
46EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.79845803
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.79221185
48REST_21632747_ChIP-Seq_MESCs_Mouse1.75763212
49DNAJC2_21179169_ChIP-ChIP_NT2_Human1.75214468
50ZFP281_18757296_ChIP-ChIP_E14_Mouse1.74267823
51IRF8_21731497_ChIP-ChIP_J774_Mouse1.67794660
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.67151817
53TP63_17297297_ChIP-ChIP_HaCaT_Human1.63931797
54KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.62493089
55SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.62416438
56IKZF1_21737484_ChIP-ChIP_HCT116_Human1.62319139
57EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.62270130
58KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.61997572
59KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.61997572
60KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.61997572
61* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.58082782
62REST_18959480_ChIP-ChIP_MESCs_Mouse1.58028938
63TET1_21490601_ChIP-Seq_MESCs_Mouse1.54902685
64MYC_19030024_ChIP-ChIP_MESCs_Mouse1.54080535
65ELK1_19687146_ChIP-ChIP_HELA_Human1.52752941
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.50115038
67EGR1_19374776_ChIP-ChIP_THP-1_Human1.46290263
68MYC_19079543_ChIP-ChIP_MESCs_Mouse1.45769599
69MYC_18358816_ChIP-ChIP_MESCs_Mouse1.44735446
70TP53_20018659_ChIP-ChIP_R1E_Mouse1.44501372
71SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.44420512
72CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.44323273
73KDM2B_26808549_Chip-Seq_SUP-B15_Human1.43146322
74CTCF_27219007_Chip-Seq_Bcells_Human1.42548032
75RING1B_27294783_Chip-Seq_ESCs_Mouse1.41607332
76RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41425980
77EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.41170073
78ZFP281_27345836_Chip-Seq_ESCs_Mouse1.39976972
79PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37934434
80UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.37145001
81ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.36116305
82EST1_17652178_ChIP-ChIP_JURKAT_Human1.36016768
83CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.31355472
84E2F1_21310950_ChIP-Seq_MCF-7_Human1.30993258
85CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.30136292
86HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.29631984
87ESR1_21235772_ChIP-Seq_MCF-7_Human1.28024950
88STAT4_19710469_ChIP-ChIP_TH1__Mouse1.27928621
89OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.27800558
90TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27424500
91SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.26184372
92IRF1_19129219_ChIP-ChIP_H3396_Human1.25561849
93LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.24921643
94SRF_21415370_ChIP-Seq_HL-1_Mouse1.24448555
95NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.22347465
96* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20915065
97WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20773452
98VDR_21846776_ChIP-Seq_THP-1_Human1.16492836
99RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.15382904
100MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.14852750
101* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.13815651
102RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12779645
103SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.12453459
104CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12382193
105ELK3_25401928_ChIP-Seq_HUVEC_Human1.12152845
106WT1_19549856_ChIP-ChIP_CCG9911_Human1.11882691
107RACK7_27058665_Chip-Seq_MCF-7_Human1.10741341
108HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09731008
109FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.09659999
110SMC3_22415368_ChIP-Seq_MEFs_Mouse1.08961241
111GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08200662
112VDR_24763502_ChIP-Seq_THP-1_Human1.07479589
113SMC1_22415368_ChIP-Seq_MEFs_Mouse1.07386941
114PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.07273508
115SMC4_20622854_ChIP-Seq_HELA_Human1.07130629
116* SA1_22415368_ChIP-Seq_MEFs_Mouse1.06452141
117SPI1_23547873_ChIP-Seq_NB4_Human1.05858193
118KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05541054
119ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.05039128
120NANOG_16153702_ChIP-ChIP_HESCs_Human1.03847212
121SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.02418947
122RARG_19884340_ChIP-ChIP_MEFs_Mouse1.02166011
123TTF2_22483619_ChIP-Seq_HELA_Human1.01707897
124RING1B_27294783_Chip-Seq_NPCs_Mouse1.01529199
125TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.00813833
126BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00721024
127PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99873538
128PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99780187
129P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99661160
130CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98944407
131TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98659818
132NFI_21473784_ChIP-Seq_ESCs_Mouse0.98050705
133VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96897560
134E2F1_18555785_ChIP-Seq_MESCs_Mouse0.96470826
135HOXB4_20404135_ChIP-ChIP_EML_Mouse0.96439932
136YY1_21170310_ChIP-Seq_MESCs_Mouse0.96371266
137RAD21_21589869_ChIP-Seq_MESCs_Mouse0.96263549
138NANOG_18555785_ChIP-Seq_MESCs_Mouse0.96146637
139EED_16625203_ChIP-ChIP_MESCs_Mouse0.95795983
140EP300_21415370_ChIP-Seq_HL-1_Mouse0.95461301
141TP53_22127205_ChIP-Seq_IMR90_Human0.95272885
142NELFA_20434984_ChIP-Seq_ESCs_Mouse0.94999959
143HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94624809
144TET1_21451524_ChIP-Seq_MESCs_Mouse0.93951166
145MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.93791436
146CJUN_26792858_Chip-Seq_BT549_Human0.93441253
147SOX2_16153702_ChIP-ChIP_HESCs_Human0.93427107
148RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.93299342
149JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.93194217
150KDM2B_26808549_Chip-Seq_DND41_Human0.92485785
151ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91137678
152CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.91134081
153GATA1_22025678_ChIP-Seq_K562_Human0.90166821
154P68_20966046_ChIP-Seq_HELA_Human0.89504632
155SRY_22984422_ChIP-ChIP_TESTIS_Rat0.88880495
156SA1_27219007_Chip-Seq_ERYTHROID_Human0.87592735
157DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.86696931
158CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.86408619
159CREB1_26743006_Chip-Seq_LNCaP_Human0.86330409
160IRF8_22096565_ChIP-ChIP_GC-B_Human0.86217870
161IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.86098613
162HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.86034840
163KDM2B_26808549_Chip-Seq_JURKAT_Human0.85746037
164OCT4_19829295_ChIP-Seq_ESCs_Human0.85649389
165NFIB_24661679_ChIP-Seq_LUNG_Mouse0.85187400
166GBX2_23144817_ChIP-Seq_PC3_Human0.85040029
167FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.84813644
168NR3C1_23031785_ChIP-Seq_PC12_Mouse0.83899688
169SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83697152
170TP53_23651856_ChIP-Seq_MEFs_Mouse0.83674709
171CLOCK_20551151_ChIP-Seq_293T_Human0.82520695
172KLF4_19829295_ChIP-Seq_ESCs_Human0.82480004
173CTCF_27219007_Chip-Seq_ERYTHROID_Human0.82473145
174MYC_19915707_ChIP-ChIP_AK7_Human0.82038102
175TCF3_18692474_ChIP-Seq_MEFs_Mouse0.81937466
176SOX2_18555785_ChIP-Seq_MESCs_Mouse0.81632519
177GATA1_19941827_ChIP-Seq_MEL_Mouse0.81427711
178MYB_21317192_ChIP-Seq_ERMYB_Mouse0.81086573
179SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.80788847
180* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.80747700
181TP63_22573176_ChIP-Seq_HFKS_Human0.80087175
182SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.79989844
183PCGF2_27294783_Chip-Seq_ESCs_Mouse0.79911832
184RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.79563358
185TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.79241654
186SMAD_19615063_ChIP-ChIP_OVARY_Human0.76753034

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.13947713
2MP0005503_abnormal_tendon_morphology5.43682919
3MP0004859_abnormal_synaptic_plasticity5.06650828
4MP0005275_abnormal_skin_tensile3.60385393
5MP0003880_abnormal_central_pattern3.22642853
6MP0004270_analgesia3.16840331
7MP0003705_abnormal_hypodermis_morpholog2.97242357
8MP0003635_abnormal_synaptic_transmissio2.82344770
9MP0005423_abnormal_somatic_nervous2.76229771
10MP0009780_abnormal_chondrocyte_physiolo2.67884432
11MP0002064_seizures2.59995985
12MP0004134_abnormal_chest_morphology2.52167615
13MP0003329_amyloid_beta_deposits2.47348847
14MP0000920_abnormal_myelination2.43230671
15MP0003279_aneurysm2.41781976
16MP0002933_joint_inflammation2.21979332
17MP0002063_abnormal_learning/memory/cond2.16945227
18MP0005508_abnormal_skeleton_morphology2.14422818
19MP0009745_abnormal_behavioral_response2.07983676
20MP0008057_abnormal_DNA_replication2.06750249
21MP0009250_abnormal_appendicular_skeleto2.06653964
22MP0001958_emphysema2.04323427
23MP0001486_abnormal_startle_reflex2.01184416
24MP0002272_abnormal_nervous_system1.99494013
25MP0005171_absent_coat_pigmentation1.99205910
26MP0002734_abnormal_mechanical_nocicepti1.98204934
27MP0006054_spinal_hemorrhage1.98178309
28MP0003656_abnormal_erythrocyte_physiolo1.94536869
29MP0003690_abnormal_glial_cell1.93435118
30MP0008569_lethality_at_weaning1.90263138
31MP0004885_abnormal_endolymph1.79964861
32MP0002572_abnormal_emotion/affect_behav1.76520088
33MP0010030_abnormal_orbit_morphology1.73910681
34MP0001968_abnormal_touch/_nociception1.73173955
35MP0000751_myopathy1.62665980
36MP0009046_muscle_twitch1.61779934
37MP0002282_abnormal_trachea_morphology1.57893573
38MP0000566_synostosis1.57310471
39MP0003879_abnormal_hair_cell1.56907883
40MP0001542_abnormal_bone_strength1.55862871
41MP0005390_skeleton_phenotype1.54839471
42MP0003634_abnormal_glial_cell1.52890272
43MP0000049_abnormal_middle_ear1.52090335
44MP0008007_abnormal_cellular_replicative1.52089705
45MP0003941_abnormal_skin_development1.51650745
46MP0003385_abnormal_body_wall1.46045307
47MP0004147_increased_porphyrin_level1.45508485
48MP0004272_abnormal_basement_membrane1.42702417
49MP0002938_white_spotting1.42236236
50MP0001348_abnormal_lacrimal_gland1.40987115
51MP0001970_abnormal_pain_threshold1.38993266
52MP0000163_abnormal_cartilage_morphology1.38133526
53MP0004858_abnormal_nervous_system1.36096620
54MP0003111_abnormal_nucleus_morphology1.35864117
55MP0003633_abnormal_nervous_system1.35549999
56MP0001299_abnormal_eye_distance/1.34388157
57MP0002108_abnormal_muscle_morphology1.32290706
58MP0006292_abnormal_olfactory_placode1.32186828
59MP0010094_abnormal_chromosome_stability1.31772051
60MP0002060_abnormal_skin_morphology1.29737878
61MP0002735_abnormal_chemical_nociception1.27139619
62MP0005257_abnormal_intraocular_pressure1.23945709
63MP0002115_abnormal_skeleton_extremities1.23791901
64MP0002113_abnormal_skeleton_development1.23085997
65MP0002396_abnormal_hematopoietic_system1.22412346
66MP0002733_abnormal_thermal_nociception1.22213700
67MP0001177_atelectasis1.21705604
68MP0002736_abnormal_nociception_after1.21118846
69MP0005623_abnormal_meninges_morphology1.20896643
70MP0000015_abnormal_ear_pigmentation1.20379145
71MP0005174_abnormal_tail_pigmentation1.20310374
72MP0000604_amyloidosis1.19199087
73MP0000778_abnormal_nervous_system1.18933075
74MP0001501_abnormal_sleep_pattern1.18638892
75MP0002249_abnormal_larynx_morphology1.18015671
76MP0003631_nervous_system_phenotype1.17959281
77MP0001243_abnormal_dermal_layer1.17740931
78MP0001502_abnormal_circadian_rhythm1.16305936
79MP0001905_abnormal_dopamine_level1.15369229
80MP0010386_abnormal_urinary_bladder1.15017984
81MP0000343_altered_response_to1.14420390
82MP0001188_hyperpigmentation1.13555017
83MP0002932_abnormal_joint_morphology1.13306776
84MP0004811_abnormal_neuron_physiology1.12859849
85MP0002109_abnormal_limb_morphology1.12238713
86MP0002066_abnormal_motor_capabilities/c1.12079899
87MP0009384_cardiac_valve_regurgitation1.11961662
88MP0000013_abnormal_adipose_tissue1.11847289
89MP0008058_abnormal_DNA_repair1.11532102
90MP0002116_abnormal_craniofacial_bone1.08934020
91MP0005397_hematopoietic_system_phenotyp1.08679655
92MP0001545_abnormal_hematopoietic_system1.08679655
93MP0003786_premature_aging1.07752640
94MP0005075_abnormal_melanosome_morpholog1.07112072
95MP0000955_abnormal_spinal_cord1.07024737
96MP0002111_abnormal_tail_morphology1.06270430
97MP0000762_abnormal_tongue_morphology1.05023464
98MP0003283_abnormal_digestive_organ1.04551907
99MP0000432_abnormal_head_morphology1.03253920
100MP0002882_abnormal_neuron_morphology1.02501834
101MP0002998_abnormal_bone_remodeling1.02231664
102MP0009333_abnormal_splenocyte_physiolog1.00732866
103MP0001533_abnormal_skeleton_physiology1.00534165
104MP0000490_abnormal_crypts_of1.00065038
105MP0002114_abnormal_axial_skeleton0.99390675
106MP0003632_abnormal_nervous_system0.99347031
107MP0002067_abnormal_sensory_capabilities0.99298506
108MP0002102_abnormal_ear_morphology0.98517963
109MP0005595_abnormal_vascular_smooth0.97298009
110MP0003755_abnormal_palate_morphology0.97037651
111MP0002557_abnormal_social/conspecific_i0.96390201
112MP0003942_abnormal_urinary_system0.95873356
113MP0008932_abnormal_embryonic_tissue0.93519335
114MP0001440_abnormal_grooming_behavior0.93300376
115MP0008995_early_reproductive_senescence0.92303928
116MP0001293_anophthalmia0.91718102
117MP0003136_yellow_coat_color0.91608609
118MP0002295_abnormal_pulmonary_circulatio0.90776509
119MP0000534_abnormal_ureter_morphology0.90679554
120MP0000767_abnormal_smooth_muscle0.90285762
121MP0003075_altered_response_to0.89918527
122MP0003077_abnormal_cell_cycle0.89023063
123MP0005367_renal/urinary_system_phenotyp0.88438915
124MP0000516_abnormal_urinary_system0.88438915
125MP0003937_abnormal_limbs/digits/tail_de0.88423536
126MP0002132_abnormal_respiratory_system0.87286292
127MP0000462_abnormal_digestive_system0.87087321
128MP0000428_abnormal_craniofacial_morphol0.85974828
129MP0003448_altered_tumor_morphology0.85550051
130MP0003795_abnormal_bone_structure0.85478904
131MP0002009_preneoplasia0.84314465
132MP0010368_abnormal_lymphatic_system0.84244950
133MP0005023_abnormal_wound_healing0.83327493
134MP0000858_altered_metastatic_potential0.83312312
135MP0000747_muscle_weakness0.80652647
136MP0002148_abnormal_hypersensitivity_rea0.79960791
137MP0009278_abnormal_bone_marrow0.79887714
138MP0004133_heterotaxia0.79658352
139MP0002233_abnormal_nose_morphology0.79087213
140MP0005058_abnormal_lysosome_morphology0.77277462
141MP0003122_maternal_imprinting0.76973995
142MP0000003_abnormal_adipose_tissue0.76287690
143MP0002184_abnormal_innervation0.75980460
144MP0010307_abnormal_tumor_latency0.75561977
145MP0003121_genomic_imprinting0.74686943
146MP0004808_abnormal_hematopoietic_stem0.74365976
147MP0003935_abnormal_craniofacial_develop0.74061715
148MP0000372_irregular_coat_pigmentation0.73450171
149MP0001175_abnormal_lung_morphology0.73286205
150MP0002229_neurodegeneration0.72933514
151MP0001963_abnormal_hearing_physiology0.72549738
152MP0005386_behavior/neurological_phenoty0.72180321
153MP0004924_abnormal_behavior0.72180321
154MP0008874_decreased_physiological_sensi0.71788675
155MP0002133_abnormal_respiratory_system0.71719140
156MP0005388_respiratory_system_phenotype0.71719140
157MP0003091_abnormal_cell_migration0.71296237
158MP0002177_abnormal_outer_ear0.70841011
159MP0002089_abnormal_postnatal_growth/wei0.70676377
160MP0002697_abnormal_eye_size0.70351107
161MP0003566_abnormal_cell_adhesion0.69727485
162MP0002152_abnormal_brain_morphology0.68903674
163MP0005646_abnormal_pituitary_gland0.68683710
164MP0000749_muscle_degeneration0.68380076
165MP0006276_abnormal_autonomic_nervous0.68209237
166MP0003172_abnormal_lysosome_physiology0.67497770
167MP0004197_abnormal_fetal_growth/weight/0.65565861
168MP0003938_abnormal_ear_development0.65360048
169MP0000579_abnormal_nail_morphology0.65256393
170MP0001286_abnormal_eye_development0.65218258
171MP0000733_abnormal_muscle_development0.65106489
172MP0000681_abnormal_thyroid_gland0.64533650
173MP0003045_fibrosis0.63331968
174MP0003567_abnormal_fetal_cardiomyocyte0.61725032
175MP0001835_abnormal_antigen_presentation0.61375437
176MP0002896_abnormal_bone_mineralization0.61311268

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.79027011
2Protrusio acetabuli (HP:0003179)4.65144913
3Irregular epiphyses (HP:0010582)4.06657676
4Epiphyseal dysplasia (HP:0002656)3.78675361
5Myokymia (HP:0002411)3.78357613
6Supranuclear gaze palsy (HP:0000605)3.61929383
7Abnormality of the heme biosynthetic pathway (HP:0010472)3.59558247
8Neurofibrillary tangles (HP:0002185)3.42374122
9Neonatal short-limb short stature (HP:0008921)3.36778171
10Mild short stature (HP:0003502)3.36328709
11Vascular tortuosity (HP:0004948)3.31590465
12Soft skin (HP:0000977)3.22268977
13Focal motor seizures (HP:0011153)3.16243716
14Action tremor (HP:0002345)3.15938602
15Bowel diverticulosis (HP:0005222)3.12779670
16Ankle clonus (HP:0011448)3.11671746
17Mesomelia (HP:0003027)3.09889921
18Focal seizures (HP:0007359)3.08014208
19Small epiphyses (HP:0010585)3.06308136
20Obstructive sleep apnea (HP:0002870)3.04805001
21Abnormality of binocular vision (HP:0011514)3.04133093
22Diplopia (HP:0000651)3.04133093
23Insomnia (HP:0100785)3.02810991
24Torticollis (HP:0000473)2.98409496
25Aortic aneurysm (HP:0004942)2.91953327
26Flat capital femoral epiphysis (HP:0003370)2.90274372
27Abnormality of dentin (HP:0010299)2.90086158
28Chromosomal breakage induced by crosslinking agents (HP:0003221)2.84522148
29Cerebral aneurysm (HP:0004944)2.81231012
30Arterial tortuosity (HP:0005116)2.80982715
31Distal upper limb amyotrophy (HP:0007149)2.77299050
32Upper limb amyotrophy (HP:0009129)2.77299050
33Spinal rigidity (HP:0003306)2.76767637
34Fragile skin (HP:0001030)2.71507594
35Vitreoretinal degeneration (HP:0000655)2.70333330
36Aortic dissection (HP:0002647)2.68320399
37Duplicated collecting system (HP:0000081)2.66790422
38Cerebral inclusion bodies (HP:0100314)2.65656766
39Pulmonary artery stenosis (HP:0004415)2.64580438
40Vertebral compression fractures (HP:0002953)2.64085727
41Biconcave vertebral bodies (HP:0004586)2.63685114
42Follicular hyperkeratosis (HP:0007502)2.61206881
43Chromsome breakage (HP:0040012)2.54452536
44Atrophic scars (HP:0001075)2.53824258
45Cervical subluxation (HP:0003308)2.52839858
46Hypoventilation (HP:0002791)2.51980811
47Osteoarthritis (HP:0002758)2.50297362
48Ankle contracture (HP:0006466)2.49164358
49Breech presentation (HP:0001623)2.48992182
50Mitral regurgitation (HP:0001653)2.47895672
51Stridor (HP:0010307)2.46521297
52Cerebral hypomyelination (HP:0006808)2.46302238
53Hand muscle atrophy (HP:0009130)2.46042060
54Hyperacusis (HP:0010780)2.45121479
55Wormian bones (HP:0002645)2.44442699
56Hypoplastic ischia (HP:0003175)2.42488069
57Abnormality of the renal collecting system (HP:0004742)2.40252393
58Hyperextensible skin (HP:0000974)2.39496299
59Bladder diverticulum (HP:0000015)2.38404801
60Broad metatarsal (HP:0001783)2.37693584
61Spastic gait (HP:0002064)2.37648856
62Epileptic encephalopathy (HP:0200134)2.33297467
63Genu varum (HP:0002970)2.32160378
64Delayed epiphyseal ossification (HP:0002663)2.30687871
65Increased variability in muscle fiber diameter (HP:0003557)2.28523498
66Absent epiphyses (HP:0010577)2.26949337
67Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.26949337
68Dilatation of the ascending aorta (HP:0005111)2.26653246
69Craniofacial dystonia (HP:0012179)2.26078791
70Absent frontal sinuses (HP:0002688)2.25779939
71Syringomyelia (HP:0003396)2.25297154
72Spinal cord lesions (HP:0100561)2.25297154
73Focal dystonia (HP:0004373)2.24633548
74Cupped ribs (HP:0000887)2.22864703
75Abnormality of the phalanges of the 2nd finger (HP:0009541)2.22236549
76Dysmetria (HP:0001310)2.19442004
77Abnormality of femoral epiphyses (HP:0006499)2.19375499
78Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.19375499
79Blue sclerae (HP:0000592)2.19219845
80Flat cornea (HP:0007720)2.18984964
81Abnormal eating behavior (HP:0100738)2.16760737
82Turricephaly (HP:0000262)2.15993156
83Peritonitis (HP:0002586)2.15425490
84Genu recurvatum (HP:0002816)2.14250671
85Atonic seizures (HP:0010819)2.13456428
86Mildly elevated creatine phosphokinase (HP:0008180)2.12238081
87Overriding aorta (HP:0002623)2.11097763
88Ulnar bowing (HP:0003031)2.11061617
89Platyspondyly (HP:0000926)2.10511291
90Febrile seizures (HP:0002373)2.10338710
91Renal duplication (HP:0000075)2.08754986
92Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.06959607
93Scanning speech (HP:0002168)2.05563473
94Visual hallucinations (HP:0002367)2.05411287
95Aplasia of the phalanges of the hand (HP:0009802)2.04466798
96Aplasia involving bones of the extremities (HP:0009825)2.04466798
97Aplasia involving bones of the upper limbs (HP:0009823)2.04466798
98Short middle phalanx of the 5th finger (HP:0004220)2.03074516
99Abnormality of the epiphysis of the femoral head (HP:0010574)2.02648684
100Coronal craniosynostosis (HP:0004440)2.02135185
101Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.01778461
102Abnormality of the acetabulum (HP:0003170)2.01682389
103Abnormality of the femoral head (HP:0003368)2.01059078
104Peripheral hypomyelination (HP:0007182)1.99765297
105Limited hip movement (HP:0008800)1.98166060
106Overgrowth (HP:0001548)1.98124415
107Abnormal number of erythroid precursors (HP:0012131)1.97798921
108Abnormality of the ischium (HP:0003174)1.97638349
109Annular pancreas (HP:0001734)1.97625200
110Intention tremor (HP:0002080)1.96306821
111Lower limb amyotrophy (HP:0007210)1.96179952
112Hypoplasia of the iris (HP:0007676)1.96009733
113Metaphyseal dysplasia (HP:0100255)1.94226777
114Achilles tendon contracture (HP:0001771)1.94016610
115Hip contracture (HP:0003273)1.93961023
116Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.92886386
117Coxa vara (HP:0002812)1.92241364
118Aortic regurgitation (HP:0001659)1.91208047
119Shallow orbits (HP:0000586)1.90960697
120Osteomalacia (HP:0002749)1.90927816
121Elfin facies (HP:0004428)1.89864866
122Abnormality of the vertebral endplates (HP:0005106)1.89864225
123Abnormality of the phalanges of the 5th finger (HP:0004213)1.89758967
124Renovascular hypertension (HP:0100817)1.86838936
125Infantile muscular hypotonia (HP:0008947)1.86656261
126Akinesia (HP:0002304)1.86652794
127Truncal ataxia (HP:0002078)1.84714558
128Generalized amyotrophy (HP:0003700)1.84690898
129Broad long bones (HP:0005622)1.84568406
130Lower limb muscle weakness (HP:0007340)1.83853396
131Nephroblastoma (Wilms tumor) (HP:0002667)1.82194596
132Hallux valgus (HP:0001822)1.81459676
133Wide anterior fontanel (HP:0000260)1.81082808
134Embryonal renal neoplasm (HP:0011794)1.80332405
135Joint laxity (HP:0001388)1.78994779
136Slender build (HP:0001533)1.78562412
137Metaphyseal cupping (HP:0003021)1.78245238
138Round ear (HP:0100830)1.77909132
139Decreased skull ossification (HP:0004331)1.77727401
140Premature skin wrinkling (HP:0100678)1.77176842
141Deviation of the hallux (HP:0010051)1.76779933
142Short femoral neck (HP:0100864)1.76599824
143Diaphragmatic weakness (HP:0009113)1.76326519
144Joint stiffness (HP:0001387)1.76189444
145Mitral valve prolapse (HP:0001634)1.76149981
146Generalized tonic-clonic seizures (HP:0002069)1.75274707
147Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.75217807
148Abnormality of the corticospinal tract (HP:0002492)1.74253376
149Morphological abnormality of the middle ear (HP:0008609)1.72757743
150Micromelia (HP:0002983)1.71794129
151Abnormal vertebral ossification (HP:0100569)1.71144164
152Abnormality of incisor morphology (HP:0011063)1.70947064
153Aplasia/Hypoplasia of the sacrum (HP:0008517)1.70418358
154Beaking of vertebral bodies (HP:0004568)1.70075098
155Abnormality of the frontal sinuses (HP:0002687)1.68880347
156Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.66544028
157Abnormal delivery (HP:0001787)1.66489442
158Spinal cord compression (HP:0002176)1.64672934
159Type I transferrin isoform profile (HP:0003642)1.64202136
160Broad phalanx (HP:0006009)1.64094284
161Increased corneal curvature (HP:0100692)1.62420165
162Keratoconus (HP:0000563)1.62420165
163Flattened epiphyses (HP:0003071)1.62326317
164Duplication of thumb phalanx (HP:0009942)1.61680268
165Limited elbow extension (HP:0001377)1.59808931
166Abnormality of the incisor (HP:0000676)1.59673433
167Flared metaphyses (HP:0003015)1.59496808
168Redundant skin (HP:0001582)1.59345994
169Type 1 muscle fiber predominance (HP:0003803)1.59324604
170Spondylolisthesis (HP:0003302)1.59318319
171Abnormality of cells of the erythroid lineage (HP:0012130)1.59290732
172Abnormality of skull ossification (HP:0002703)1.58450907
173Broad palm (HP:0001169)1.57668258

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B4.17926080
2PAK63.94853235
3EPHA43.58633079
4DDR23.50044185
5NTRK12.99687155
6MKNK12.92566727
7MARK12.89374862
8NTRK32.85332727
9PIM22.70810151
10PRKD32.63636981
11DAPK22.63575477
12ZAK2.52626424
13NME22.36489584
14MKNK22.35411949
15CLK12.27602826
16IRAK42.15909221
17TRPM72.12494357
18LIMK12.10859077
19LATS22.07382496
20PDGFRA2.06674682
21RIPK12.05629676
22TESK11.97039297
23EIF2AK21.93903153
24TRIB31.93876179
25STK161.93263318
26ARAF1.90345133
27SRPK11.85271973
28NTRK21.81480147
29CAMKK11.79219971
30EIF2AK11.72780350
31STK41.68061727
32GRK51.67671694
33STK381.61195931
34IKBKB1.60504668
35PIM11.60490276
36BLK1.56837984
37MYLK1.54138575
38CAMK2B1.50987159
39CDC71.46068656
40MINK11.43096411
41YES11.42612308
42CAMK2G1.41529764
43CDK71.38273963
44PTK21.37345193
45TYRO31.36045559
46PBK1.32484007
47STK241.32425039
48MAP3K141.30105021
49MAP3K91.28363418
50KSR21.26718074
51DAPK31.24295832
52STK38L1.23588517
53IRAK31.20687864
54TNIK1.20071492
55TLK11.19795189
56ROCK21.16720202
57BUB11.16623493
58KIT1.16199345
59CAMK11.14157521
60CDK51.13964567
61TXK1.13237965
62PRKCH1.12436424
63STK31.10476259
64VRK11.09659102
65ERBB31.08530078
66PHKG21.07971163
67PHKG11.07971163
68MAPKAPK51.04461691
69CDK151.02962289
70EPHA31.00248654
71BRSK21.00166002
72LATS10.99826070
73CDK180.96375050
74DAPK10.95564067
75ACVR1B0.94930580
76IKBKE0.94281835
77PRKD20.94225418
78CDK11A0.94209959
79PLK10.93585322
80CAMK2D0.93371312
81SIK10.91294584
82MARK20.91236591
83CHUK0.90542150
84DYRK20.89819699
85ERN10.89664513
86LMTK20.89245711
87MOS0.87853673
88PAK30.87320982
89ATR0.85801183
90CDK140.85651851
91ROCK10.84675605
92SGK2230.84492880
93SGK4940.84492880
94ADRBK20.83816844
95CHEK20.83533703
96PRKG20.82317540
97NEK60.81598836
98BMX0.79852750
99PRKCG0.77138424
100RPS6KA60.75555955
101MAPK120.74478494
102MET0.74477583
103CAMK2A0.74230281
104RPS6KA20.73980365
105MAP3K130.71870388
106TTK0.71778632
107AURKA0.71358961
108WNK10.71248646
109RPS6KC10.70966704
110RPS6KL10.70966704
111PRKD10.70705063
112PDPK10.70379136
113ILK0.69381705
114ABL20.69059901
115NUAK10.68984294
116PTK2B0.68819549
117UHMK10.68553382
118DYRK30.66705809
119TGFBR20.66523793
120PLK30.65749189
121BRSK10.65707528
122BRAF0.65605438
123PKN10.65005748
124PDGFRB0.64513431
125PLK40.63529971
126ICK0.63451613
127MAP2K10.62880915
128MAPK100.62759003
129LYN0.62506807
130CDC42BPA0.62429898
131TTN0.62263208
132CDK80.60483909
133AURKB0.60301416
134MAPKAPK20.60263241
135SIK20.59565851
136BTK0.58950948
137MAP3K110.58452054
138FGFR20.58263250
139RPS6KA50.57603902
140NEK90.56388507
141MATK0.55821453
142WEE10.55052828
143JAK30.53728998
144TNK20.53381098
145GRK10.53380369
146BMPR1B0.52908079
147BMPR20.52886571
148CDK30.52101958
149MAPK130.51889887
150MAPK70.51673886
151DYRK1A0.50645952
152RET0.49548694
153ALK0.48133797
154PLK20.48004281
155CSF1R0.47382508
156TEC0.45712119
157ADRBK10.45344778
158MAPK30.45197252
159NLK0.44154316
160PAK20.44088962
161RPS6KA40.43549507
162PAK10.43544590
163STK100.43337765
164PDK10.43329988
165GSK3A0.42120589
166MAPK10.42036211
167EPHB10.41106528
168BRD40.41100859
169SRC0.41075961
170GRK70.40228668
171CSNK2A10.39782173
172MAP3K60.39146027
173EPHB20.38943773
174SGK30.38906301
175PIK3CG0.38649400
176TAOK20.38306276
177RPS6KA30.38053889
178AKT30.38025937
179MST40.37864666
180ATM0.37563973
181PINK10.37476958
182PKN20.37322150
183CASK0.37061178
184PAK40.36515703
185CSK0.36250823
186AKT10.36015914
187MAPKAPK30.35652557

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.30433612
2DNA replication_Homo sapiens_hsa030303.06180319
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.69863099
4Nicotine addiction_Homo sapiens_hsa050332.56844334
5ECM-receptor interaction_Homo sapiens_hsa045122.42733022
6Base excision repair_Homo sapiens_hsa034102.37324966
7Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.32628926
8Mismatch repair_Homo sapiens_hsa034302.31693127
9Homologous recombination_Homo sapiens_hsa034402.21685432
10Insulin secretion_Homo sapiens_hsa049112.17423902
11Circadian entrainment_Homo sapiens_hsa047132.12719792
12Long-term potentiation_Homo sapiens_hsa047202.09266588
13GABAergic synapse_Homo sapiens_hsa047272.09052302
14Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.08758813
15Glutamatergic synapse_Homo sapiens_hsa047242.02226306
16Amphetamine addiction_Homo sapiens_hsa050312.01964667
17Morphine addiction_Homo sapiens_hsa050322.00573766
18Malaria_Homo sapiens_hsa051441.93444218
19Gastric acid secretion_Homo sapiens_hsa049711.91859999
20Fanconi anemia pathway_Homo sapiens_hsa034601.91326947
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.88829205
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.80290826
23Nucleotide excision repair_Homo sapiens_hsa034201.78782437
24Ribosome_Homo sapiens_hsa030101.77850356
25Cocaine addiction_Homo sapiens_hsa050301.74882833
26Cell cycle_Homo sapiens_hsa041101.70544296
27p53 signaling pathway_Homo sapiens_hsa041151.68381637
28Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.68066164
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.65664306
30Dopaminergic synapse_Homo sapiens_hsa047281.65059693
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.59924334
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.59380859
33Salivary secretion_Homo sapiens_hsa049701.54950791
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.51914969
35Non-homologous end-joining_Homo sapiens_hsa034501.46965806
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.46378813
37Spliceosome_Homo sapiens_hsa030401.45151169
38Cholinergic synapse_Homo sapiens_hsa047251.44514953
39Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.42006719
40Protein digestion and absorption_Homo sapiens_hsa049741.40997867
41Vitamin B6 metabolism_Homo sapiens_hsa007501.39036984
42RNA polymerase_Homo sapiens_hsa030201.38181155
43Basal transcription factors_Homo sapiens_hsa030221.35563801
44Oxytocin signaling pathway_Homo sapiens_hsa049211.34861268
45Calcium signaling pathway_Homo sapiens_hsa040201.29229218
46Basal cell carcinoma_Homo sapiens_hsa052171.29077938
47Estrogen signaling pathway_Homo sapiens_hsa049151.28021799
48Glioma_Homo sapiens_hsa052141.26762811
49cAMP signaling pathway_Homo sapiens_hsa040241.25286132
50GnRH signaling pathway_Homo sapiens_hsa049121.23696381
51Melanogenesis_Homo sapiens_hsa049161.23336651
52Phospholipase D signaling pathway_Homo sapiens_hsa040721.22433380
53Prion diseases_Homo sapiens_hsa050201.20191176
54Dilated cardiomyopathy_Homo sapiens_hsa054141.19907528
55Renin secretion_Homo sapiens_hsa049241.16420422
56Gap junction_Homo sapiens_hsa045401.15885662
57Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.15196655
58Axon guidance_Homo sapiens_hsa043601.13402267
59Pyrimidine metabolism_Homo sapiens_hsa002401.13360163
60Graft-versus-host disease_Homo sapiens_hsa053321.12730800
61Histidine metabolism_Homo sapiens_hsa003401.12491253
62PI3K-Akt signaling pathway_Homo sapiens_hsa041511.12453681
63Hedgehog signaling pathway_Homo sapiens_hsa043401.11394592
64Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.10835686
65Vibrio cholerae infection_Homo sapiens_hsa051101.10100532
66Arachidonic acid metabolism_Homo sapiens_hsa005901.09806548
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.08262245
68TGF-beta signaling pathway_Homo sapiens_hsa043501.08216064
69cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07622295
70Hematopoietic cell lineage_Homo sapiens_hsa046401.06090354
71Leishmaniasis_Homo sapiens_hsa051401.06067661
72Focal adhesion_Homo sapiens_hsa045101.05699496
73NF-kappa B signaling pathway_Homo sapiens_hsa040641.04641244
74Transcriptional misregulation in cancer_Homo sapiens_hsa052021.04525531
75Allograft rejection_Homo sapiens_hsa053301.04440400
76Protein export_Homo sapiens_hsa030601.02781183
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.02188134
78Measles_Homo sapiens_hsa051621.02122668
79Herpes simplex infection_Homo sapiens_hsa051681.01433222
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01115966
81Other glycan degradation_Homo sapiens_hsa005111.01025996
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.00951349
83MicroRNAs in cancer_Homo sapiens_hsa052061.00564244
84Small cell lung cancer_Homo sapiens_hsa052220.98242989
85RNA degradation_Homo sapiens_hsa030180.97577106
86Autoimmune thyroid disease_Homo sapiens_hsa053200.97438416
87Thyroid hormone synthesis_Homo sapiens_hsa049180.94708496
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.94669705
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94563720
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.94539031
91Rap1 signaling pathway_Homo sapiens_hsa040150.93198141
92Sphingolipid metabolism_Homo sapiens_hsa006000.92473817
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.90995417
94Apoptosis_Homo sapiens_hsa042100.90658408
95Long-term depression_Homo sapiens_hsa047300.90547514
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88882599
97Arginine and proline metabolism_Homo sapiens_hsa003300.88323665
98Endocytosis_Homo sapiens_hsa041440.88255931
99Proteasome_Homo sapiens_hsa030500.88207766
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88161208
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.87818353
102Bile secretion_Homo sapiens_hsa049760.85882583
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.85085054
104VEGF signaling pathway_Homo sapiens_hsa043700.85018582
105ErbB signaling pathway_Homo sapiens_hsa040120.84836390
106Intestinal immune network for IgA production_Homo sapiens_hsa046720.84283352
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81878579
108HTLV-I infection_Homo sapiens_hsa051660.81833894
109Systemic lupus erythematosus_Homo sapiens_hsa053220.81225170
110RNA transport_Homo sapiens_hsa030130.80859895
111One carbon pool by folate_Homo sapiens_hsa006700.80732656
112Ras signaling pathway_Homo sapiens_hsa040140.80727738
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80004838
114Notch signaling pathway_Homo sapiens_hsa043300.79355511
115Hippo signaling pathway_Homo sapiens_hsa043900.79020258
116MAPK signaling pathway_Homo sapiens_hsa040100.76453499
117AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76082270
118Asthma_Homo sapiens_hsa053100.75529363
119Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74611606
120Phagosome_Homo sapiens_hsa041450.73829340
121Viral carcinogenesis_Homo sapiens_hsa052030.73760273
122Glycosaminoglycan degradation_Homo sapiens_hsa005310.73566116
123Taste transduction_Homo sapiens_hsa047420.72852507
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72845768
125Legionellosis_Homo sapiens_hsa051340.72679327
126Pathways in cancer_Homo sapiens_hsa052000.72144357
127Serotonergic synapse_Homo sapiens_hsa047260.71787457
128Melanoma_Homo sapiens_hsa052180.71425221
129Pancreatic secretion_Homo sapiens_hsa049720.71327267
130Wnt signaling pathway_Homo sapiens_hsa043100.70966980
131Purine metabolism_Homo sapiens_hsa002300.70939215
132Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70914761
133Steroid biosynthesis_Homo sapiens_hsa001000.70373770
134Hepatitis B_Homo sapiens_hsa051610.70358999
135Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.69185887
136Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69152050
137Olfactory transduction_Homo sapiens_hsa047400.68971098
138N-Glycan biosynthesis_Homo sapiens_hsa005100.68513566
139Prostate cancer_Homo sapiens_hsa052150.68348166
140Inositol phosphate metabolism_Homo sapiens_hsa005620.67410772
141Sphingolipid signaling pathway_Homo sapiens_hsa040710.66751140
142Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64830270
143Jak-STAT signaling pathway_Homo sapiens_hsa046300.64406547
144Shigellosis_Homo sapiens_hsa051310.64332418
145beta-Alanine metabolism_Homo sapiens_hsa004100.64228890
146mRNA surveillance pathway_Homo sapiens_hsa030150.62259763
147Lysosome_Homo sapiens_hsa041420.60892373
148Primary immunodeficiency_Homo sapiens_hsa053400.58683981
149TNF signaling pathway_Homo sapiens_hsa046680.58373057
150Proteoglycans in cancer_Homo sapiens_hsa052050.57920159
151RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57563538
152Bladder cancer_Homo sapiens_hsa052190.57245306
153Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56233005
154Choline metabolism in cancer_Homo sapiens_hsa052310.56156954
155Salmonella infection_Homo sapiens_hsa051320.55152481
156Toxoplasmosis_Homo sapiens_hsa051450.54414432
157Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54259404
158Chronic myeloid leukemia_Homo sapiens_hsa052200.53555603
159Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53119136
160Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52471161
161Viral myocarditis_Homo sapiens_hsa054160.51951799
162Amoebiasis_Homo sapiens_hsa051460.51487357
163Central carbon metabolism in cancer_Homo sapiens_hsa052300.51110038
164Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50705741
165Collecting duct acid secretion_Homo sapiens_hsa049660.50371626
166Pertussis_Homo sapiens_hsa051330.50022451
167Tight junction_Homo sapiens_hsa045300.48976684
168Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48729226
169Tuberculosis_Homo sapiens_hsa051520.48072224
170Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.47881055
171Rheumatoid arthritis_Homo sapiens_hsa053230.47710040
172Glucagon signaling pathway_Homo sapiens_hsa049220.47577441
173Ether lipid metabolism_Homo sapiens_hsa005650.47521653
174Cardiac muscle contraction_Homo sapiens_hsa042600.47399373
175Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47021743
176Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44331247
177mTOR signaling pathway_Homo sapiens_hsa041500.43552106
178AMPK signaling pathway_Homo sapiens_hsa041520.41799966
179Mineral absorption_Homo sapiens_hsa049780.41205167

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