CERK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation (Kim et al., 2006 [PubMed 16488390]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.22056157
2B cell receptor signaling pathway (GO:0050853)4.96340591
3positive regulation of B cell differentiation (GO:0045579)4.53895384
4negative regulation of erythrocyte differentiation (GO:0045647)4.36161804
5macrophage activation involved in immune response (GO:0002281)4.15834534
6regulation of gamma-delta T cell differentiation (GO:0045586)4.06470192
7positive regulation by symbiont of host defense response (GO:0052509)3.94891716
8modulation by symbiont of host defense response (GO:0052031)3.94891716
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.94891716
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.94891716
11positive regulation by organism of defense response of other organism involved in symbiotic interact3.94891716
12modulation by symbiont of host immune response (GO:0052553)3.94891716
13regulation of interferon-beta biosynthetic process (GO:0045357)3.94492641
14negative regulation of cell killing (GO:0031342)3.88485648
15negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.88485648
16regulation of B cell receptor signaling pathway (GO:0050855)3.88006553
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.79540868
18positive T cell selection (GO:0043368)3.76554196
19regulation of gamma-delta T cell activation (GO:0046643)3.74420424
20NIK/NF-kappaB signaling (GO:0038061)3.73518960
21sodium ion export (GO:0071436)3.71471994
22negative thymic T cell selection (GO:0045060)3.60783383
23regulation of ARF protein signal transduction (GO:0032012)3.60036265
24activated T cell proliferation (GO:0050798)3.59841589
25regulation of B cell differentiation (GO:0045577)3.55769275
26positive regulation of mast cell activation involved in immune response (GO:0033008)3.51356116
27positive regulation of mast cell degranulation (GO:0043306)3.51356116
28negative T cell selection (GO:0043383)3.50079277
29neutrophil activation involved in immune response (GO:0002283)3.47045625
30thymic T cell selection (GO:0045061)3.44156642
31positive regulation of mast cell activation (GO:0033005)3.40789676
32response to muramyl dipeptide (GO:0032495)3.39772880
33positive regulation of histone deacetylation (GO:0031065)3.32930717
34potassium ion import (GO:0010107)3.25542435
35cellular potassium ion homeostasis (GO:0030007)3.15494517
36serine transport (GO:0032329)3.14133499
37response to interleukin-15 (GO:0070672)3.09585046
38mannose metabolic process (GO:0006013)3.08511614
39neutrophil activation (GO:0042119)3.03025287
40leukocyte aggregation (GO:0070486)3.02691149
41positive thymic T cell selection (GO:0045059)3.00642250
42natural killer cell differentiation (GO:0001779)3.00281610
43positive regulation of leukocyte degranulation (GO:0043302)2.99852854
44cellular response to zinc ion (GO:0071294)2.96719781
45negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.95930243
46granulocyte activation (GO:0036230)2.94863222
47adaptation of signaling pathway (GO:0023058)2.93964050
48antigen processing and presentation of endogenous antigen (GO:0019883)2.93482662
49antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.92354535
50antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.92354535
51L-serine transport (GO:0015825)2.91884818
52regulation of mast cell degranulation (GO:0043304)2.90684397
53tolerance induction (GO:0002507)2.89837323
54cortical actin cytoskeleton organization (GO:0030866)2.88360517
55myeloid cell activation involved in immune response (GO:0002275)2.88199237
56locomotory exploration behavior (GO:0035641)2.87776021
57regulation of leukocyte degranulation (GO:0043300)2.84736781
58regulation of ARF GTPase activity (GO:0032312)2.84315489
59regulation of interleukin-12 biosynthetic process (GO:0045075)2.82181013
60positive regulation of Rap GTPase activity (GO:0032854)2.80071392
61negative regulation of bone resorption (GO:0045779)2.79881817
62protein localization to endosome (GO:0036010)2.78257422
63germ cell migration (GO:0008354)2.77908499
64phosphatidylinositol dephosphorylation (GO:0046856)2.76110690
65regulation of extracellular matrix disassembly (GO:0010715)2.74269766
66activation of JUN kinase activity (GO:0007257)2.72689991
67synaptic vesicle maturation (GO:0016188)2.72092662
68cell migration in hindbrain (GO:0021535)2.70584305
69response to laminar fluid shear stress (GO:0034616)2.69836212
70regulation of defense response to virus by virus (GO:0050690)2.69637330
71negative regulation of glial cell proliferation (GO:0060253)2.68360894
72cellular response to prostaglandin stimulus (GO:0071379)2.67000268
73detection of other organism (GO:0098543)2.66172697
74positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.66124135
75regulation of mast cell activation involved in immune response (GO:0033006)2.65750342
76regulation of regulated secretory pathway (GO:1903305)2.63885551
77positive regulation of macrophage cytokine production (GO:0060907)2.63016263
78histone H3-K36 demethylation (GO:0070544)2.61906476
79cellular response to interleukin-15 (GO:0071350)2.60323639
80negative regulation of lymphocyte mediated immunity (GO:0002707)2.59507641
81positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.59495568
82antigen processing and presentation via MHC class Ib (GO:0002475)2.59320530
83macrophage activation (GO:0042116)2.58861032
84regulation of natural killer cell mediated immunity (GO:0002715)2.58090923
85regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.58090923
86negative regulation of granulocyte differentiation (GO:0030853)2.58080419
87positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.57565261
88regulation of myeloid leukocyte mediated immunity (GO:0002886)2.56921718
89negative regulation of phagocytosis (GO:0050765)2.56572613
90Fc receptor mediated stimulatory signaling pathway (GO:0002431)2.56001989
91immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00022.55628312
92Fc-gamma receptor signaling pathway (GO:0038094)2.55628312
93Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)2.55628312
94regulation of T cell tolerance induction (GO:0002664)2.51616269
95negative regulation of toll-like receptor signaling pathway (GO:0034122)2.50788712
96negative regulation of leukocyte mediated immunity (GO:0002704)2.50660502
97detection of bacterium (GO:0016045)2.49984513
98regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.49381156
99cellular extravasation (GO:0045123)2.47846681
100clathrin coat assembly (GO:0048268)2.46299806
101phospholipid dephosphorylation (GO:0046839)2.45143755
102positive regulation of bone resorption (GO:0045780)2.43736977
103positive regulation of bone remodeling (GO:0046852)2.43736977
104positive regulation of cell adhesion mediated by integrin (GO:0033630)2.42472751
105response to host immune response (GO:0052572)2.42431200
106response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.42431200
107cellular response to monoamine stimulus (GO:0071868)2.42339562
108cellular response to catecholamine stimulus (GO:0071870)2.42339562
109cortical cytoskeleton organization (GO:0030865)2.42017173
110I-kappaB phosphorylation (GO:0007252)2.40956655
111positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.40539633
112response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.40048425
113response to host (GO:0075136)2.40048425
114response to host defenses (GO:0052200)2.40048425
115negative regulation of T cell mediated immunity (GO:0002710)2.38373098
116negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.37204048
117dopamine receptor signaling pathway (GO:0007212)2.36212814
118positive regulation of regulated secretory pathway (GO:1903307)2.35751490
119peptidyl-lysine dimethylation (GO:0018027)2.35634815
120respiratory burst (GO:0045730)2.35433136
121T cell migration (GO:0072678)2.34534356
122cytoskeletal anchoring at plasma membrane (GO:0007016)2.34164223
123regulation of mast cell activation (GO:0033003)2.34000568
124regulation of Rap GTPase activity (GO:0032317)2.33671282
125regulation of macrophage cytokine production (GO:0010935)2.33355681
126neutrophil mediated immunity (GO:0002446)2.32754003
127regulation of platelet aggregation (GO:0090330)2.32407281
128pinocytosis (GO:0006907)2.32378244
129antigen receptor-mediated signaling pathway (GO:0050851)2.31559039
130relaxation of cardiac muscle (GO:0055119)2.30826121
131positive regulation of protein deacetylation (GO:0090312)2.30336145
132cerebellar Purkinje cell differentiation (GO:0021702)2.28954173
133T cell selection (GO:0045058)2.28711166
134negative regulation of type 2 immune response (GO:0002829)2.26805382
135adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.23918013
136negative regulation of Ras protein signal transduction (GO:0046580)2.22081669
137regulation of glial cell proliferation (GO:0060251)2.20833202
138establishment of nucleus localization (GO:0040023)2.17636305
1393-UTR-mediated mRNA stabilization (GO:0070935)2.17293046
140hypothalamus development (GO:0021854)2.16864621
141signal complex assembly (GO:0007172)2.16860623
142regulation of amyloid precursor protein catabolic process (GO:1902991)2.16530821
143B cell homeostasis (GO:0001782)2.16171123
144venous blood vessel morphogenesis (GO:0048845)2.15353054
145negative regulation of myotube differentiation (GO:0010832)2.13589271
146negative regulation of glycoprotein biosynthetic process (GO:0010561)2.13135058
147negative regulation of small GTPase mediated signal transduction (GO:0051058)2.12530125
148cellular response to nerve growth factor stimulus (GO:1990090)2.11488617
149response to nerve growth factor (GO:1990089)2.11488617
150mucosal-associated lymphoid tissue development (GO:0048537)2.11143510
151Peyers patch development (GO:0048541)2.11143510
152stress fiber assembly (GO:0043149)2.10356114
153regulation of tolerance induction (GO:0002643)2.10193854
154detection of external biotic stimulus (GO:0098581)2.09317069
155T cell homeostasis (GO:0043029)2.06533188
156response to parathyroid hormone (GO:0071107)2.06067156
157negative regulation of interleukin-12 production (GO:0032695)2.05917135
158negative regulation of innate immune response (GO:0045824)2.05008503
159regulation of beta-amyloid formation (GO:1902003)2.03335772
160positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.03132830

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.34141772
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.23678832
3MYC_22102868_ChIP-Seq_BL_Human3.22038058
4VDR_21846776_ChIP-Seq_THP-1_Human3.06972015
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.02293441
6IRF8_27001747_Chip-Seq_BMDM_Mouse2.85005566
7* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.76058787
8* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.74157732
9KDM2B_26808549_Chip-Seq_SUP-B15_Human2.72340699
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.53339472
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.52951796
12KDM2B_26808549_Chip-Seq_DND41_Human2.52232259
13* TCF7_22412390_ChIP-Seq_EML_Mouse2.51491459
14E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.49192804
15RUNX_20019798_ChIP-Seq_JUKART_Human2.43379699
16SPI1_23127762_ChIP-Seq_K562_Human2.41717038
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.38751189
18SCL_19346495_ChIP-Seq_HPC-7_Human2.38675709
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.37610623
20VDR_24763502_ChIP-Seq_THP-1_Human2.28936776
21KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.26366350
22VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.25398101
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.14718848
24* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.13936343
25KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.02714561
26UTX_26944678_Chip-Seq_JUKART_Human1.98460391
27* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.97821905
28MYB_21317192_ChIP-Seq_ERMYB_Mouse1.97800664
29NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.96158621
30MAF_26560356_Chip-Seq_TH1_Human1.95412782
31* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.88625431
32GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.84932111
33MYB_26560356_Chip-Seq_TH2_Human1.81309125
34EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78005832
35* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.75944900
36STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.75289459
37SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.73502015
38KDM2B_26808549_Chip-Seq_K562_Human1.69464908
39LXR_22292898_ChIP-Seq_THP-1_Human1.68596910
40KDM2B_26808549_Chip-Seq_JURKAT_Human1.65919071
41* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.63983812
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.63863084
43DROSHA_22980978_ChIP-Seq_HELA_Human1.63658389
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.63521639
45MYB_26560356_Chip-Seq_TH1_Human1.58954785
46BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.55796057
47* RUNX1_22412390_ChIP-Seq_EML_Mouse1.55737328
48IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.53171573
49STAT6_21828071_ChIP-Seq_BEAS2B_Human1.51720492
50ERG_21242973_ChIP-ChIP_JURKAT_Human1.50489687
51* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.49117687
52PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.48700805
53JARID2_20064375_ChIP-Seq_MESCs_Mouse1.47288388
54* ELK3_25401928_ChIP-Seq_HUVEC_Human1.46540372
55GATA1_19941826_ChIP-Seq_K562_Human1.43156368
56FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.42957609
57GATA1_19941827_ChIP-Seq_MEL_Mouse1.41533408
58GATA3_27048872_Chip-Seq_THYMUS_Human1.40000397
59BP1_19119308_ChIP-ChIP_Hs578T_Human1.39940217
60RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.39259338
61VDR_24787735_ChIP-Seq_THP-1_Human1.38687547
62SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.38600056
63TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.38264567
64RARB_27405468_Chip-Seq_BRAIN_Mouse1.34731388
65* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33219170
66GATA1_22025678_ChIP-Seq_K562_Human1.31506779
67SPI1_23547873_ChIP-Seq_NB4_Human1.30307692
68GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25630992
69RNF2_27304074_Chip-Seq_ESCs_Mouse1.25368244
70PU_27001747_Chip-Seq_BMDM_Mouse1.24886455
71* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.24117280
72GATA2_21666600_ChIP-Seq_HMVEC_Human1.23661038
73DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.22541809
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.20964605
75* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.20428677
76ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.19725300
77FOXM1_23109430_ChIP-Seq_U2OS_Human1.18352777
78SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17734578
79* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.16963471
80* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.16963471
81EZH2_22144423_ChIP-Seq_EOC_Human1.16494395
82JARID2_20075857_ChIP-Seq_MESCs_Mouse1.16271420
83* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.15810408
84CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.14877891
85MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14255145
86RARG_19884340_ChIP-ChIP_MEFs_Mouse1.11296668
87SA1_27219007_Chip-Seq_ERYTHROID_Human1.10310476
88* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.09812778
89GATA2_19941826_ChIP-Seq_K562_Human1.09422960
90* TET1_21451524_ChIP-Seq_MESCs_Mouse1.07868690
91* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.07678562
92P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07676915
93TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07239664
94* SMC4_20622854_ChIP-Seq_HELA_Human1.06594359
95UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04503351
96STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.03239714
97CTCF_27219007_Chip-Seq_Bcells_Human1.03213446
98CREB1_26743006_Chip-Seq_LNCaP_Human1.02446057
99KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02418458
100P68_20966046_ChIP-Seq_HELA_Human1.01426534
101* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.01193430
102MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.00765726
103MAF_26560356_Chip-Seq_TH2_Human1.00461117
104SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.00218363
105* EZH2_27294783_Chip-Seq_ESCs_Mouse0.99500489
106* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.98606279
107* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.98552409
108RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97933860
109PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97674523
110DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97274337
111FOXO3_23340844_ChIP-Seq_DLD1_Human0.96481131
112* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95186280
113LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.94144336
114TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.93984928
115SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.93873413
116NCOR1_26117541_ChIP-Seq_K562_Human0.93873350
117STAT4_19710469_ChIP-ChIP_TH1__Mouse0.93796213
118CTCF_27219007_Chip-Seq_ERYTHROID_Human0.93761691
119NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93667080
120REST_18959480_ChIP-ChIP_MESCs_Mouse0.93239871
121RING1B_27294783_Chip-Seq_ESCs_Mouse0.92192870
122MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.92142574
123* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91653091
124RUNX1_27514584_Chip-Seq_MCF-7_Human0.91521601
125CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91516574
126* TBX20_22080862_ChIP-Seq_HEART_Mouse0.90470217
127* TBX20_22328084_ChIP-Seq_HEART_Mouse0.90470217
128GATA2_22383799_ChIP-Seq_G1ME_Mouse0.89382134
129RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.88298759
130KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.87733570
131SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.87677807
132RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87329068
133RACK7_27058665_Chip-Seq_MCF-7_Human0.85183325
134TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.83195000

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.80991195
2MP0000569_abnormal_digit_pigmentation3.73850972
3MP0003172_abnormal_lysosome_physiology3.16319798
4MP0003300_gastrointestinal_ulcer3.10296135
5MP0001835_abnormal_antigen_presentation3.01048611
6MP0005058_abnormal_lysosome_morphology2.81683378
7MP0001800_abnormal_humoral_immune2.54283631
8MP0001790_abnormal_immune_system2.52965610
9MP0005387_immune_system_phenotype2.52965610
10MP0003123_paternal_imprinting2.48888153
11MP0001348_abnormal_lacrimal_gland2.44738095
12MP0005409_darkened_coat_color2.39572690
13MP0003724_increased_susceptibility_to2.38060983
14MP0004510_myositis2.38056910
15MP0003183_abnormal_peptide_metabolism2.34037882
16MP0002452_abnormal_antigen_presenting2.23475576
17MP0009278_abnormal_bone_marrow2.22810345
18MP0000685_abnormal_immune_system2.16009338
19MP0005000_abnormal_immune_tolerance2.07049603
20MP0002009_preneoplasia2.03131814
21MP0002166_altered_tumor_susceptibility1.95080127
22MP0002420_abnormal_adaptive_immunity1.92679013
23MP0002822_catalepsy1.91290784
24MP0003436_decreased_susceptibility_to1.89652426
25MP0001819_abnormal_immune_cell1.89542456
26MP0002723_abnormal_immune_serum1.88445124
27MP0002419_abnormal_innate_immunity1.83342718
28MP0004859_abnormal_synaptic_plasticity1.83242521
29MP0005174_abnormal_tail_pigmentation1.76078784
30MP0005671_abnormal_response_to1.74318111
31MP0008569_lethality_at_weaning1.73865839
32MP0002398_abnormal_bone_marrow1.73058178
33MP0002909_abnormal_adrenal_gland1.72827458
34MP0003045_fibrosis1.69951166
35MP0003279_aneurysm1.67816545
36MP0004947_skin_inflammation1.65762460
37MP0003690_abnormal_glial_cell1.65691967
38MP0005464_abnormal_platelet_physiology1.65415181
39MP0008961_abnormal_basal_metabolism1.57017764
40* MP0000716_abnormal_immune_system1.56092364
41MP0003122_maternal_imprinting1.53726589
42MP0000604_amyloidosis1.53188568
43MP0004808_abnormal_hematopoietic_stem1.52298650
44MP0005076_abnormal_cell_differentiation1.51489404
45MP0000689_abnormal_spleen_morphology1.51027919
46MP0006082_CNS_inflammation1.50876429
47MP0002877_abnormal_melanocyte_morpholog1.44414575
48* MP0005025_abnormal_response_to1.41324455
49MP0003283_abnormal_digestive_organ1.38863518
50MP0009046_muscle_twitch1.38074350
51MP0001986_abnormal_taste_sensitivity1.38071024
52MP0010307_abnormal_tumor_latency1.37258977
53MP0000465_gastrointestinal_hemorrhage1.35807814
54MP0002722_abnormal_immune_system1.34276280
55MP0000015_abnormal_ear_pigmentation1.33533051
56MP0006054_spinal_hemorrhage1.31831998
57MP0003191_abnormal_cellular_cholesterol1.31803958
58MP0000703_abnormal_thymus_morphology1.27491342
59MP0002163_abnormal_gland_morphology1.25377206
60MP0005310_abnormal_salivary_gland1.22409712
61MP0009333_abnormal_splenocyte_physiolog1.22285132
62MP0002148_abnormal_hypersensitivity_rea1.21192086
63* MP0002429_abnormal_blood_cell1.20505070
64MP0001851_eye_inflammation1.19666524
65MP0002006_tumorigenesis1.18358058
66MP0002405_respiratory_system_inflammati1.17856629
67MP0003566_abnormal_cell_adhesion1.10721304
68MP0004270_analgesia1.09403210
69MP0000013_abnormal_adipose_tissue1.08462350
70MP0001845_abnormal_inflammatory_respons1.08315415
71MP0002998_abnormal_bone_remodeling1.07986931
72MP0001188_hyperpigmentation1.06955144
73MP0009785_altered_susceptibility_to1.06571753
74MP0001270_distended_abdomen1.05741261
75MP0008260_abnormal_autophagy1.05489421
76MP0002138_abnormal_hepatobiliary_system1.04956842
77MP0003879_abnormal_hair_cell1.04514243
78MP0001873_stomach_inflammation1.01867335
79MP0010234_abnormal_vibrissa_follicle1.01769239
80MP0010155_abnormal_intestine_physiology1.01624194
81MP0003075_altered_response_to1.01177151
82MP0003633_abnormal_nervous_system1.00232780
83MP0003635_abnormal_synaptic_transmissio1.00202310
84MP0009379_abnormal_foot_pigmentation0.99414196
85* MP0003866_abnormal_defecation0.98843358
86MP0005167_abnormal_blood-brain_barrier0.97784736
87MP0001533_abnormal_skeleton_physiology0.97301335
88MP0000767_abnormal_smooth_muscle0.94456839
89MP0010368_abnormal_lymphatic_system0.94421664
90MP0004185_abnormal_adipocyte_glucose0.94181803
91MP0002064_seizures0.94069537
92MP0002396_abnormal_hematopoietic_system0.93392650
93MP0002090_abnormal_vision0.92961472
94MP0002063_abnormal_learning/memory/cond0.92843381
95MP0000920_abnormal_myelination0.92464409
96MP0001879_abnormal_lymphatic_vessel0.91894032
97MP0002653_abnormal_ependyma_morphology0.90347069
98MP0004130_abnormal_muscle_cell0.88604658
99MP0005397_hematopoietic_system_phenotyp0.88399055
100MP0001545_abnormal_hematopoietic_system0.88399055
101MP0003329_amyloid_beta_deposits0.87140344
102MP0003091_abnormal_cell_migration0.86430853
103MP0003634_abnormal_glial_cell0.85152357
104MP0002095_abnormal_skin_pigmentation0.85102721
105MP0003763_abnormal_thymus_physiology0.84952446
106MP0005257_abnormal_intraocular_pressure0.82747513
107MP0005166_decreased_susceptibility_to0.82163985
108MP0003787_abnormal_imprinting0.81827400
109MP0001958_emphysema0.81720213
110MP0002638_abnormal_pupillary_reflex0.81344870
111MP0009840_abnormal_foam_cell0.81300224
112MP0004858_abnormal_nervous_system0.80443858
113MP0000955_abnormal_spinal_cord0.77594668
114MP0002933_joint_inflammation0.76290960
115MP0000858_altered_metastatic_potential0.75225448
116MP0008004_abnormal_stomach_pH0.74132971
117MP0009780_abnormal_chondrocyte_physiolo0.73440708
118MP0000003_abnormal_adipose_tissue0.71412640
119MP0003448_altered_tumor_morphology0.70676726
120MP0004084_abnormal_cardiac_muscle0.70569833
121MP0005390_skeleton_phenotype0.70013021
122MP0003828_pulmonary_edema0.69980260
123MP0002693_abnormal_pancreas_physiology0.69916866
124MP0003121_genomic_imprinting0.69356213
125MP0000477_abnormal_intestine_morphology0.68462011
126MP0000490_abnormal_crypts_of0.68403724
127MP0008874_decreased_physiological_sensi0.67894466
128MP0000371_diluted_coat_color0.67758415
129MP0004885_abnormal_endolymph0.67404274
130MP0001849_ear_inflammation0.66566223
131MP0001663_abnormal_digestive_system0.65768084
132MP0003948_abnormal_gas_homeostasis0.65662729
133MP0003705_abnormal_hypodermis_morpholog0.65349088
134MP0002067_abnormal_sensory_capabilities0.64633594

Predicted human phenotypes

RankGene SetZ-score
1Cellulitis (HP:0100658)4.42041334
2Agammaglobulinemia (HP:0004432)4.18705662
3Increased cerebral lipofuscin (HP:0011813)4.13873460
4Verrucae (HP:0200043)3.86088178
5Papilloma (HP:0012740)3.86088178
6Colitis (HP:0002583)3.85301717
7Recurrent abscess formation (HP:0002722)3.53289013
8Recurrent viral infections (HP:0004429)3.43585767
9Thyroiditis (HP:0100646)3.39917711
10Inflammation of the large intestine (HP:0002037)3.27778303
11Gastrointestinal inflammation (HP:0004386)3.24486158
12Recurrent bacterial skin infections (HP:0005406)3.23958152
13B lymphocytopenia (HP:0010976)3.20547543
14Abnormality of B cell number (HP:0010975)3.20547543
15Increased neuronal autofluorescent lipopigment (HP:0002074)3.04129436
16Abnormality of glycolipid metabolism (HP:0010969)3.02156833
17Abnormality of liposaccharide metabolism (HP:0010968)3.02156833
18Abnormality of glycosphingolipid metabolism (HP:0004343)3.02156833
19Supranuclear gaze palsy (HP:0000605)2.97799132
20Dysostosis multiplex (HP:0000943)2.95983773
21Panhypogammaglobulinemia (HP:0003139)2.90412169
22Eczematoid dermatitis (HP:0000976)2.89375675
23Recurrent bronchitis (HP:0002837)2.88251766
24Recurrent fungal infections (HP:0002841)2.86451775
25Meningitis (HP:0001287)2.77641259
26Spinal cord lesions (HP:0100561)2.71811209
27Syringomyelia (HP:0003396)2.71811209
28Disinhibition (HP:0000734)2.69757488
29Osteomyelitis (HP:0002754)2.68959238
30Myositis (HP:0100614)2.68903264
31Gastrointestinal stroma tumor (HP:0100723)2.58352400
32Urinary glycosaminoglycan excretion (HP:0003541)2.55401259
33Mucopolysacchariduria (HP:0008155)2.55401259
34Neuronal loss in central nervous system (HP:0002529)2.52668471
35Papilledema (HP:0001085)2.52018329
36Loss of speech (HP:0002371)2.50562501
37Cerebral aneurysm (HP:0004944)2.48345633
38Hematochezia (HP:0002573)2.46264827
39Abnormality of glycosaminoglycan metabolism (HP:0004371)2.45639841
40Abnormality of mucopolysaccharide metabolism (HP:0011020)2.45639841
41Abnormality of polysaccharide metabolism (HP:0011012)2.45639841
42Sepsis (HP:0100806)2.44025840
43Hyperacusis (HP:0010780)2.41358032
44Vertebral arch anomaly (HP:0008438)2.40475391
45Annular pancreas (HP:0001734)2.39487221
46Increased CSF protein (HP:0002922)2.37578890
47Action tremor (HP:0002345)2.35866864
48Gastrointestinal infarctions (HP:0005244)2.35532391
49Visual hallucinations (HP:0002367)2.34968299
50Orchitis (HP:0100796)2.33317322
51Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.31023825
52Abnormality of the fingertips (HP:0001211)2.30407239
53Obstructive sleep apnea (HP:0002870)2.29348170
54Facial diplegia (HP:0001349)2.28553436
55Hemiplegia (HP:0002301)2.26321974
56Apathy (HP:0000741)2.22397986
57Hypercortisolism (HP:0001578)2.21260410
58Deep palmar crease (HP:0006191)2.20556608
59Macroorchidism (HP:0000053)2.19008541
60Hand muscle atrophy (HP:0009130)2.18228193
61Diminished motivation (HP:0000745)2.16072201
62Neonatal hypoglycemia (HP:0001998)2.16005554
63Recurrent gram-negative bacterial infections (HP:0005420)2.15196588
64Elevated erythrocyte sedimentation rate (HP:0003565)2.13170360
65Small epiphyses (HP:0010585)2.12573020
66Genu recurvatum (HP:0002816)2.12199734
67Mediastinal lymphadenopathy (HP:0100721)2.11802173
68Emphysema (HP:0002097)2.10804335
69Hepatoblastoma (HP:0002884)2.10625095
70Agitation (HP:0000713)2.09743713
71Disproportionate tall stature (HP:0001519)2.06628884
72Growth hormone excess (HP:0000845)2.06619298
73Asymmetric septal hypertrophy (HP:0001670)2.06121944
74Abnormal delayed hypersensitivity skin test (HP:0002963)2.04983879
75Hypoventilation (HP:0002791)2.04965962
76Chronic otitis media (HP:0000389)2.04639902
77Recurrent skin infections (HP:0001581)2.03924483
78Diplopia (HP:0000651)2.03588926
79Abnormality of binocular vision (HP:0011514)2.03588926
80Retrobulbar optic neuritis (HP:0100654)2.03360861
81Optic neuritis (HP:0100653)2.03360861
82Vacuolated lymphocytes (HP:0001922)2.02257473
83Recurrent sinusitis (HP:0011108)2.01771101
84Chest pain (HP:0100749)1.99837128
85Abnormal pancreas size (HP:0012094)1.99808959
86Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.99714435
87Mitral stenosis (HP:0001718)1.97533290
88Chronic sinusitis (HP:0011109)1.97102703
89Distal upper limb amyotrophy (HP:0007149)1.96626362
90Upper limb amyotrophy (HP:0009129)1.96626362
91Eosinophilia (HP:0001880)1.96017088
92T lymphocytopenia (HP:0005403)1.94929225
93Ankle clonus (HP:0011448)1.94828789
94Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.94717544
95Abnormality of macrophages (HP:0004311)1.94075198
96Hypoplasia of the thymus (HP:0000778)1.93955975
97Dysmetric saccades (HP:0000641)1.93332236
98Dislocated radial head (HP:0003083)1.92961700
99Restrictive lung disease (HP:0002091)1.92942698
100Inappropriate behavior (HP:0000719)1.92796445
101Increased IgE level (HP:0003212)1.90733192
102Mutism (HP:0002300)1.90466745
103IgM deficiency (HP:0002850)1.90285822
104Global brain atrophy (HP:0002283)1.88235318
105Slow saccadic eye movements (HP:0000514)1.88100587
106Interstitial pulmonary disease (HP:0006530)1.87573325
107Abnormality of ocular smooth pursuit (HP:0000617)1.86525328
108Spontaneous hematomas (HP:0007420)1.85324360
109Enlarged penis (HP:0000040)1.85255029
110Hyperparathyroidism (HP:0000843)1.85140266
111Persistence of primary teeth (HP:0006335)1.85094909
112Truncal ataxia (HP:0002078)1.84747263
113Abnormality of the radial head (HP:0003995)1.84724331
114Impaired smooth pursuit (HP:0007772)1.83967127
115Spinal canal stenosis (HP:0003416)1.83436307
116Striae distensae (HP:0001065)1.82413523
117Autoimmune thrombocytopenia (HP:0001973)1.82165075
118Turricephaly (HP:0000262)1.81135415
119Recurrent cutaneous fungal infections (HP:0011370)1.80589466
120Chronic mucocutaneous candidiasis (HP:0002728)1.80589466
121Rectal prolapse (HP:0002035)1.80520539
122Nasal polyposis (HP:0100582)1.80463415
123Chronic obstructive pulmonary disease (HP:0006510)1.80025037
124Obstructive lung disease (HP:0006536)1.80025037
125Gingivitis (HP:0000230)1.79881173
126Flattened epiphyses (HP:0003071)1.79691270
127Postural instability (HP:0002172)1.79051636
128Peritonitis (HP:0002586)1.77505613
129Fatigue (HP:0012378)1.76733080
130Abnormality of T cell number (HP:0011839)1.76582856
131Asymmetry of the thorax (HP:0001555)1.76561255
132Axonal loss (HP:0003447)1.76344353
133Menstrual irregularities (HP:0000858)1.75217815
134Periodontitis (HP:0000704)1.75115914
135Severe combined immunodeficiency (HP:0004430)1.72892105
136Abnormality of the nasal mucosa (HP:0000433)1.72480403
137Thoracic kyphosis (HP:0002942)1.71716058
138Protrusio acetabuli (HP:0003179)1.71563166
139Pulmonary embolism (HP:0002204)1.70762413
140Lower limb asymmetry (HP:0100559)1.69749250
141Vasculitis (HP:0002633)1.68205656
142Thickened calvaria (HP:0002684)1.67680105
143Germ cell neoplasia (HP:0100728)1.67379481
144Overgrowth (HP:0001548)1.67325936
145Mitral valve prolapse (HP:0001634)1.67123095
146Hemoptysis (HP:0002105)1.66630492
147Pulmonary infiltrates (HP:0002113)1.64291805
148Increased variability in muscle fiber diameter (HP:0003557)1.64120417
149Abnormality of the right ventricle (HP:0001707)1.61951665
150Abnormality of the thoracic spine (HP:0100711)1.60471005
151Stomatitis (HP:0010280)1.59519607
152Hyperthyroidism (HP:0000836)1.59224586
153Lymphopenia (HP:0001888)1.58846100
154Long toe (HP:0010511)1.58403386
155Thin bony cortex (HP:0002753)1.58180093
156Abnormality of the intervertebral disk (HP:0005108)1.57862828
157Anomalous pulmonary venous return (HP:0010772)1.57062399
158Leukocytosis (HP:0001974)1.56545954
159Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.56464564
160Short 4th metacarpal (HP:0010044)1.56464564

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K104.68676348
2PRPF4B3.63218476
3TRIB33.19948502
4RIPK43.19384926
5MAP4K12.85193808
6ERN12.68080057
7EEF2K2.67980070
8SIK22.38881480
9GRK62.11758871
10PKN22.07679929
11RIPK12.06613367
12FES2.03220811
13PTK61.83666802
14CAMKK21.72103434
15CAMK1G1.71910722
16SYK1.71755886
17MAP3K111.71472706
18CAMKK11.70520712
19FGFR41.61697868
20WNK11.60934609
21CSF1R1.58029344
22TGFBR21.48317008
23BTK1.45458602
24CAMK1D1.44939372
25TYK21.42740093
26PRKCH1.42173412
27SCYL21.39477698
28EPHB11.39472627
29JAK11.38191830
30HCK1.35456814
31KIT1.34012575
32HIPK21.31838092
33TXK1.30894960
34NTRK11.26256655
35BLK1.25331034
36TBK11.22859825
37CDK121.19757038
38TAOK31.17281295
39NTRK21.15588460
40ALK1.15389057
41PRKD31.14217163
42LRRK21.12466649
43PASK1.09179032
44SGK31.07496233
45SMG11.07188842
46FGFR21.04155960
47FGFR31.00923159
48ITK1.00665364
49ZAP700.97250043
50PDK10.95680077
51SGK2230.94783546
52SGK4940.94783546
53UHMK10.93268106
54MAP2K20.92942550
55RPS6KC10.91966366
56RPS6KL10.91966366
57MAP3K20.91718734
58TNK20.91639086
59RET0.90155243
60MAP3K60.89628156
61MAP3K90.88524002
62STK100.88104994
63KSR20.86931068
64PRKD10.85823707
65TTN0.84004599
66PDGFRA0.82648610
67DYRK1B0.82047020
68MARK30.81367200
69CSK0.80289881
70JAK20.80005256
71NLK0.79968197
72LCK0.76940511
73NEK20.76675587
74MAP3K130.76662740
75CDK90.76415077
76PAK60.74802318
77MAP3K70.74689870
78DAPK20.74502834
79IRAK20.73244334
80RPS6KA60.73022043
81LYN0.72761459
82MAP2K30.72134397
83FYN0.71766536
84CDK60.71757847
85MAPK120.71654927
86SIK10.70706992
87DMPK0.69066649
88PDPK10.68653479
89MATK0.65412470
90STK110.64424171
91MAP2K40.63439466
92ICK0.63004531
93CAMK40.60167641
94PRKD20.59194430
95MARK20.57775046
96EPHA30.57335760
97STK380.57038726
98CDC42BPA0.56698162
99NTRK30.55422874
100SGK20.55274205
101MAP3K10.54636003
102CDK40.54309270
103MAPK70.53802783
104MAP3K40.53245291
105MTOR0.52889785
106CLK10.52824672
107LMTK20.52635405
108SIK30.52558910
109TIE10.51925307
110MAP3K140.51871561
111STK40.51620141
112TYRO30.51139708
113PDGFRB0.51037386
114STK240.50999253
115IRAK10.50182255
116PAK40.49319079
117EGFR0.49308003
118IKBKE0.48751511
119RPS6KA20.48683670
120PIM10.46131860
121CAMK10.45587569
122BMX0.44509527
123TAOK10.43771963
124IRAK40.39149638
125MAPKAPK30.38252891
126ABL10.38016790
127SRC0.37967337
128MINK10.37702345
129JAK30.37380656

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046622.83785980
2Osteoclast differentiation_Homo sapiens_hsa043802.03248225
3Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.92904178
4Primary immunodeficiency_Homo sapiens_hsa053401.85555322
5Glycosaminoglycan degradation_Homo sapiens_hsa005311.71163558
6Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.67767142
7Type II diabetes mellitus_Homo sapiens_hsa049301.64783076
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.64428511
9Phosphatidylinositol signaling system_Homo sapiens_hsa040701.62649268
10Lysosome_Homo sapiens_hsa041421.57763002
11Carbohydrate digestion and absorption_Homo sapiens_hsa049731.57164474
12Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.42852996
13Olfactory transduction_Homo sapiens_hsa047401.41987915
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.40480904
15Leishmaniasis_Homo sapiens_hsa051401.39709775
16Neurotrophin signaling pathway_Homo sapiens_hsa047221.38058693
17Chronic myeloid leukemia_Homo sapiens_hsa052201.36220936
18Long-term potentiation_Homo sapiens_hsa047201.32170272
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.30605888
20Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28265381
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.27663616
22Tuberculosis_Homo sapiens_hsa051521.27053157
23Notch signaling pathway_Homo sapiens_hsa043301.26929684
24Chemokine signaling pathway_Homo sapiens_hsa040621.26181613
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.25412446
26Non-small cell lung cancer_Homo sapiens_hsa052231.21646365
27Synaptic vesicle cycle_Homo sapiens_hsa047211.19510049
28Glioma_Homo sapiens_hsa052141.17346645
29Platelet activation_Homo sapiens_hsa046111.17277072
30Other glycan degradation_Homo sapiens_hsa005111.15853609
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12251293
32Gastric acid secretion_Homo sapiens_hsa049711.11720681
33Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.11384153
34Toll-like receptor signaling pathway_Homo sapiens_hsa046201.10398467
35Inositol phosphate metabolism_Homo sapiens_hsa005621.09903347
36Phospholipase D signaling pathway_Homo sapiens_hsa040721.09699376
37mTOR signaling pathway_Homo sapiens_hsa041501.08695564
38VEGF signaling pathway_Homo sapiens_hsa043701.08527764
39Estrogen signaling pathway_Homo sapiens_hsa049151.06703453
40Morphine addiction_Homo sapiens_hsa050321.04051590
41Pancreatic cancer_Homo sapiens_hsa052121.03102081
42Toxoplasmosis_Homo sapiens_hsa051451.02133428
43Salivary secretion_Homo sapiens_hsa049701.01880313
44Glutamatergic synapse_Homo sapiens_hsa047241.01741421
45T cell receptor signaling pathway_Homo sapiens_hsa046601.01615844
46Circadian entrainment_Homo sapiens_hsa047131.00519276
47Endocytosis_Homo sapiens_hsa041441.00352865
48Dorso-ventral axis formation_Homo sapiens_hsa043201.00240731
49Renin secretion_Homo sapiens_hsa049240.97535368
50Antigen processing and presentation_Homo sapiens_hsa046120.97125421
51Cholinergic synapse_Homo sapiens_hsa047250.95040094
52Insulin secretion_Homo sapiens_hsa049110.94975202
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93930581
54NF-kappa B signaling pathway_Homo sapiens_hsa040640.93743722
55Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.93364556
56cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92557671
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.92554179
58Rap1 signaling pathway_Homo sapiens_hsa040150.90946955
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.90643937
60Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89183874
61GnRH signaling pathway_Homo sapiens_hsa049120.88257468
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87514459
63Oxytocin signaling pathway_Homo sapiens_hsa049210.87457130
64Acute myeloid leukemia_Homo sapiens_hsa052210.87329806
65Long-term depression_Homo sapiens_hsa047300.86917192
66Insulin resistance_Homo sapiens_hsa049310.82846735
67Salmonella infection_Homo sapiens_hsa051320.82508154
68Dopaminergic synapse_Homo sapiens_hsa047280.82187333
69Apoptosis_Homo sapiens_hsa042100.80954544
70Renal cell carcinoma_Homo sapiens_hsa052110.80494380
71Insulin signaling pathway_Homo sapiens_hsa049100.79831964
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.79032661
73Pertussis_Homo sapiens_hsa051330.78470269
74Pancreatic secretion_Homo sapiens_hsa049720.77938488
75cAMP signaling pathway_Homo sapiens_hsa040240.77201680
76RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76178668
77Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.75654108
78Gap junction_Homo sapiens_hsa045400.75414919
79Ras signaling pathway_Homo sapiens_hsa040140.74740315
80Hematopoietic cell lineage_Homo sapiens_hsa046400.73806411
81Thyroid cancer_Homo sapiens_hsa052160.73563508
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.73228467
83Measles_Homo sapiens_hsa051620.71349356
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70677381
85Endometrial cancer_Homo sapiens_hsa052130.70572977
86Hepatitis B_Homo sapiens_hsa051610.70554226
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70520036
88Type I diabetes mellitus_Homo sapiens_hsa049400.70153519
89Melanogenesis_Homo sapiens_hsa049160.69853718
90Shigellosis_Homo sapiens_hsa051310.69691613
91MAPK signaling pathway_Homo sapiens_hsa040100.69021902
92Amphetamine addiction_Homo sapiens_hsa050310.69001355
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.68943219
94Choline metabolism in cancer_Homo sapiens_hsa052310.68221139
95Prion diseases_Homo sapiens_hsa050200.67808146
96Viral myocarditis_Homo sapiens_hsa054160.67775749
97Colorectal cancer_Homo sapiens_hsa052100.67571654
98Hepatitis C_Homo sapiens_hsa051600.67359474
99Staphylococcus aureus infection_Homo sapiens_hsa051500.67037588
100Prolactin signaling pathway_Homo sapiens_hsa049170.66847643
101Prostate cancer_Homo sapiens_hsa052150.66833332
102Influenza A_Homo sapiens_hsa051640.66826279
103GABAergic synapse_Homo sapiens_hsa047270.65309918
104Axon guidance_Homo sapiens_hsa043600.65256814
105Proteoglycans in cancer_Homo sapiens_hsa052050.64912624
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64598136
107FoxO signaling pathway_Homo sapiens_hsa040680.63791396
108Cocaine addiction_Homo sapiens_hsa050300.63381348
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62783869
110Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62586772
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62424398
112Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62381725
113ErbB signaling pathway_Homo sapiens_hsa040120.61226159
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.60828193
115NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60783548
116Amoebiasis_Homo sapiens_hsa051460.60537589
117Focal adhesion_Homo sapiens_hsa045100.59662147
118Intestinal immune network for IgA production_Homo sapiens_hsa046720.58714717
119Phagosome_Homo sapiens_hsa041450.58049057
120Thyroid hormone synthesis_Homo sapiens_hsa049180.57867908
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57338707
122TNF signaling pathway_Homo sapiens_hsa046680.57212960

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