CERKL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene was initially identified as a locus (RP26) associated with an autosomal recessive form of retinitis pigmentosa (arRP) disease. This gene encodes a protein with ceramide kinase-like domains, however, the protein does not phosphorylate ceramide and its target substrate is currently unknown. This protein may be a negative regulator of apoptosis in photoreceptor cells. Mutations in this gene cause a form of retinitis pigmentosa characterized by autosomal recessive cone and rod dystrophy (arCRD). Alternative splicing of this gene results in multiple transcript variants encoding different isoforms and non-coding transcripts. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.17813014
2signal peptide processing (GO:0006465)5.80225880
3regulation of B cell receptor signaling pathway (GO:0050855)5.54419451
4positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.97305776
5negative regulation of cell killing (GO:0031342)4.96908495
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.96908495
7positive regulation of granulocyte differentiation (GO:0030854)4.79759170
8positive regulation of B cell differentiation (GO:0045579)4.62611738
9regulation of gamma-delta T cell differentiation (GO:0045586)4.52935161
10antigen processing and presentation of endogenous antigen (GO:0019883)4.46861583
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.45380761
12regulation of gamma-delta T cell activation (GO:0046643)4.43609721
13positive thymic T cell selection (GO:0045059)4.29662736
14B cell receptor signaling pathway (GO:0050853)4.24668811
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.15501234
16regulation of B cell differentiation (GO:0045577)4.13284420
17negative T cell selection (GO:0043383)4.06241714
18positive T cell selection (GO:0043368)4.01485610
19negative thymic T cell selection (GO:0045060)3.96334741
20positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.92987298
21endocrine pancreas development (GO:0031018)3.86290945
22regulation of type B pancreatic cell apoptotic process (GO:2000674)3.76887051
23regulation of alpha-beta T cell proliferation (GO:0046640)3.68078928
24response to interleukin-15 (GO:0070672)3.67394307
25regulation of tolerance induction (GO:0002643)3.62231134
26defense response to protozoan (GO:0042832)3.60134379
27regulation of hexokinase activity (GO:1903299)3.59273581
28regulation of glucokinase activity (GO:0033131)3.59273581
29photoreceptor cell maintenance (GO:0045494)3.58397982
30mucosal-associated lymphoid tissue development (GO:0048537)3.54413723
31Peyers patch development (GO:0048541)3.54413723
32leukocyte aggregation (GO:0070486)3.54205687
33immunoglobulin mediated immune response (GO:0016064)3.52471520
34positive regulation of alpha-beta T cell proliferation (GO:0046641)3.52111756
35negative regulation of T cell mediated immunity (GO:0002710)3.42447765
36cellular response to interleukin-15 (GO:0071350)3.41314774
37megakaryocyte development (GO:0035855)3.38409026
38T cell selection (GO:0045058)3.37429075
39positive regulation of interleukin-17 production (GO:0032740)3.36001814
40negative regulation of lymphocyte mediated immunity (GO:0002707)3.34761697
41regulation of interleukin-17 production (GO:0032660)3.31545516
42positive regulation by symbiont of host defense response (GO:0052509)3.30743078
43modulation by symbiont of host defense response (GO:0052031)3.30743078
44modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.30743078
45modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.30743078
46positive regulation by organism of defense response of other organism involved in symbiotic interact3.30743078
47modulation by symbiont of host immune response (GO:0052553)3.30743078
48regulation of T cell tolerance induction (GO:0002664)3.30635475
49glandular epithelial cell differentiation (GO:0002067)3.30559722
50regulation of granulocyte differentiation (GO:0030852)3.30529997
51response to protozoan (GO:0001562)3.27912389
52definitive hemopoiesis (GO:0060216)3.26247485
53regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.25373838
54regulation of rhodopsin mediated signaling pathway (GO:0022400)3.25238561
55tolerance induction (GO:0002507)3.23302787
56antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.22917559
57nucleotide transmembrane transport (GO:1901679)3.22711826
58negative regulation of interleukin-12 production (GO:0032695)3.20965455
59cellular extravasation (GO:0045123)3.20157343
60activated T cell proliferation (GO:0050798)3.19689135
61antigen receptor-mediated signaling pathway (GO:0050851)3.19669309
62positive regulation of tolerance induction (GO:0002645)3.17429241
63negative regulation of erythrocyte differentiation (GO:0045647)3.16633021
64positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.16314922
65production of molecular mediator involved in inflammatory response (GO:0002532)3.16079813
66eye photoreceptor cell development (GO:0042462)3.15430439
67photoreceptor cell development (GO:0042461)3.14239678
68rhodopsin mediated signaling pathway (GO:0016056)3.13345909
69thymic T cell selection (GO:0045061)3.12736201
70mast cell degranulation (GO:0043303)3.12694833
71mast cell activation involved in immune response (GO:0002279)3.12694833
72regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.10023856
73regulation of natural killer cell mediated immunity (GO:0002715)3.10023856
74regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.09695841
75negative regulation of execution phase of apoptosis (GO:1900118)3.06925040
76peptide hormone processing (GO:0016486)3.06513033
77positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.05739405
78regulation of T cell mediated cytotoxicity (GO:0001914)3.04850115
79myeloid cell activation involved in immune response (GO:0002275)3.04645710
80leukocyte degranulation (GO:0043299)3.03651640
81positive regulation of alpha-beta T cell activation (GO:0046635)3.02358642
82regulation of alpha-beta T cell activation (GO:0046634)3.02350057
83detection of light stimulus involved in visual perception (GO:0050908)3.02231236
84detection of light stimulus involved in sensory perception (GO:0050962)3.02231236
85regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.02071427
86negative regulation of leukocyte mediated immunity (GO:0002704)3.00887379
87deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.00263423
88regulation of regulatory T cell differentiation (GO:0045589)3.00211084
89B cell mediated immunity (GO:0019724)2.99411100
90mature B cell differentiation involved in immune response (GO:0002313)2.99017729
91G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.98264409
92Arp2/3 complex-mediated actin nucleation (GO:0034314)2.97789155
93dendritic cell chemotaxis (GO:0002407)2.96398017
94negative regulation of interleukin-17 production (GO:0032700)2.95883096
95negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.95727359
96regulation of germinal center formation (GO:0002634)2.95551453
97positive regulation of T cell mediated cytotoxicity (GO:0001916)2.93279046
98positive regulation of insulin secretion (GO:0032024)2.93091298
99neutrophil activation (GO:0042119)2.91532528
100natural killer cell activation involved in immune response (GO:0002323)2.91393104
101nucleoside diphosphate catabolic process (GO:0009134)2.87302417
102positive regulation of mast cell activation (GO:0033005)2.84758312
103interferon-gamma-mediated signaling pathway (GO:0060333)2.84635331
104negative regulation of T cell apoptotic process (GO:0070233)2.83734497
105eosinophil chemotaxis (GO:0048245)2.82731925
106peptidyl-histidine modification (GO:0018202)2.82595380
107negative regulation of T-helper cell differentiation (GO:0045623)2.82080903
108negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.82080903
109regulation of mast cell degranulation (GO:0043304)2.81141996
110negative regulation of viral genome replication (GO:0045071)2.81104261
111regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.80499924
112regulation of interleukin-2 biosynthetic process (GO:0045076)2.80328199
113T cell receptor signaling pathway (GO:0050852)2.80215065
114response to type I interferon (GO:0034340)2.78976235
115poly(A)+ mRNA export from nucleus (GO:0016973)2.77984930
116cellular response to type I interferon (GO:0071357)2.77940955
117type I interferon signaling pathway (GO:0060337)2.77940955
118ER overload response (GO:0006983)2.77836580
119interleukin-1-mediated signaling pathway (GO:0070498)2.77482587
120mature B cell differentiation (GO:0002335)2.77476644
121regulation of mast cell activation (GO:0033003)2.76220275
122platelet dense granule organization (GO:0060155)2.74967072
123response to peptidoglycan (GO:0032494)2.74271263
124superoxide anion generation (GO:0042554)2.72956385
125insulin secretion (GO:0030073)2.71806001
126cytochrome complex assembly (GO:0017004)2.71422431
127dentate gyrus development (GO:0021542)2.70974837
128daunorubicin metabolic process (GO:0044597)2.70738653
129polyketide metabolic process (GO:0030638)2.70738653
130doxorubicin metabolic process (GO:0044598)2.70738653
131negative regulation of transcription by competitive promoter binding (GO:0010944)2.70084270
132mast cell activation (GO:0045576)2.69894940
133negative regulation of osteoblast proliferation (GO:0033689)2.67768793
134respiratory chain complex IV assembly (GO:0008535)2.67204985
135GDP-mannose metabolic process (GO:0019673)2.66357598
136endosome to pigment granule transport (GO:0043485)2.65577083
137endosome to melanosome transport (GO:0035646)2.65577083
138interferon-gamma production (GO:0032609)2.64960641
139detection of other organism (GO:0098543)2.64106578
140energy homeostasis (GO:0097009)2.57719307
141detection of bacterium (GO:0016045)2.57520574
142regulation of uterine smooth muscle contraction (GO:0070472)2.56952738
143retinal cone cell development (GO:0046549)2.56919687
144regulation of activation of Janus kinase activity (GO:0010533)2.55563405
145GMP metabolic process (GO:0046037)2.52561073
146positive regulation of T cell migration (GO:2000406)2.50197769
147righting reflex (GO:0060013)2.48960955
148fucose metabolic process (GO:0006004)2.46925815
149dendritic cell migration (GO:0036336)2.46311733
150eosinophil migration (GO:0072677)2.46169055
151positive regulation of uterine smooth muscle contraction (GO:0070474)2.44836628
152regulation of insulin secretion (GO:0050796)2.44630095
153negative regulation of norepinephrine secretion (GO:0010700)2.43692329
154regulation of nuclear cell cycle DNA replication (GO:0033262)2.43261753
155response to pheromone (GO:0019236)2.42753787
156anterograde synaptic vesicle transport (GO:0048490)2.41699459
157negative regulation of glycoprotein biosynthetic process (GO:0010561)2.41282982
158regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.40576112
159GPI anchor biosynthetic process (GO:0006506)2.39943687
160positive regulation of defense response to virus by host (GO:0002230)2.39289849
161DNA strand renaturation (GO:0000733)2.38047145
162sequestering of metal ion (GO:0051238)2.34725560
163DNA deamination (GO:0045006)2.32879874
164detection of calcium ion (GO:0005513)2.31857351
165positive regulation of peptide hormone secretion (GO:0090277)2.31828971
166toxin transport (GO:1901998)2.31356074
167detection of chemical stimulus (GO:0009593)2.31320143
168regulation of peptide hormone secretion (GO:0090276)2.29751174
169regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.28865172
170regulation of axon regeneration (GO:0048679)2.28068777
171regulation of neuron projection regeneration (GO:0070570)2.28068777
172mannosylation (GO:0097502)2.27410913
173neutrophil activation involved in immune response (GO:0002283)2.26610369
174regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.26480169
175regulation of timing of cell differentiation (GO:0048505)2.26160286
176T cell migration (GO:0072678)2.26007629
177regulation of peptide secretion (GO:0002791)2.25225253
178protein K63-linked deubiquitination (GO:0070536)2.24853840
179negative regulation of catecholamine secretion (GO:0033604)2.24813160
180positive regulation of lymphocyte migration (GO:2000403)2.24801332
181glycosphingolipid catabolic process (GO:0046479)2.24784124
182dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.24560061
183ceramide catabolic process (GO:0046514)2.24087888
184developmental pigmentation (GO:0048066)2.23050210
185CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.22436670
186protein-chromophore linkage (GO:0018298)2.22025004
187intraciliary transport (GO:0042073)2.21846822
188lymph node development (GO:0048535)2.21042145
189negative regulation of cAMP-mediated signaling (GO:0043951)2.20799035
190regulation of hormone secretion (GO:0046883)2.20198678
191regulation of T cell migration (GO:2000404)2.19904377

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.41676375
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.30712242
3RUNX_20019798_ChIP-Seq_JUKART_Human3.29492041
4MYB_26560356_Chip-Seq_TH2_Human3.14672918
5ELF1_17652178_ChIP-ChIP_JURKAT_Human2.97437744
6IGF1R_20145208_ChIP-Seq_DFB_Human2.87884792
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.86914038
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.69690883
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.65449388
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.63190875
11GBX2_23144817_ChIP-Seq_PC3_Human2.60487799
12FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.44007598
13MYB_26560356_Chip-Seq_TH1_Human2.38222881
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.36998401
15GATA3_27048872_Chip-Seq_THYMUS_Human2.32665191
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.23096367
17SUZ12_27294783_Chip-Seq_NPCs_Mouse2.22578650
18VDR_24763502_ChIP-Seq_THP-1_Human2.20301368
19LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.18024102
20NFE2_27457419_Chip-Seq_LIVER_Mouse2.17606706
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.16412754
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.13693793
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.13274108
24EZH2_27294783_Chip-Seq_NPCs_Mouse2.05068859
25BP1_19119308_ChIP-ChIP_Hs578T_Human2.01672684
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.00234796
27PCGF2_27294783_Chip-Seq_NPCs_Mouse1.99184370
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.94037824
29MAF_26560356_Chip-Seq_TH1_Human1.93987452
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.93959051
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.91209250
32GATA3_26560356_Chip-Seq_TH2_Human1.91195434
33* STAT3_18555785_Chip-Seq_ESCs_Mouse1.90859387
34IRF8_21731497_ChIP-ChIP_J774_Mouse1.90301295
35UTX_26944678_Chip-Seq_JUKART_Human1.87010662
36SCL_19346495_ChIP-Seq_HPC-7_Human1.85580375
37NMYC_18555785_Chip-Seq_ESCs_Mouse1.85284602
38VDR_24787735_ChIP-Seq_THP-1_Human1.83817350
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.79624886
40* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.79189073
41E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.78526511
42* P53_22387025_ChIP-Seq_ESCs_Mouse1.76755309
43* NANOG_18555785_Chip-Seq_ESCs_Mouse1.76074073
44* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.75517105
45FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.74971008
46MYC_22102868_ChIP-Seq_BL_Human1.71626963
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.71022510
48VDR_21846776_ChIP-Seq_THP-1_Human1.69646231
49SPI1_23127762_ChIP-Seq_K562_Human1.68409934
50* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.64627970
51RUNX1_22412390_ChIP-Seq_EML_Mouse1.64529316
52ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.64281304
53* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.62273836
54* E2F1_18555785_Chip-Seq_ESCs_Mouse1.62155861
55ESRRB_18555785_Chip-Seq_ESCs_Mouse1.60882255
56ZFX_18555785_Chip-Seq_ESCs_Mouse1.60837036
57TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.60343060
58VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.60248924
59KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.60157256
60MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.58934009
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.57890235
62* SOX2_18555785_Chip-Seq_ESCs_Mouse1.56263859
63* P300_18555785_Chip-Seq_ESCs_Mouse1.55982217
64PU1_27457419_Chip-Seq_LIVER_Mouse1.55553435
65CMYC_18555785_Chip-Seq_ESCs_Mouse1.54872475
66PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.53588876
67MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.53181108
68BRD4_27068464_Chip-Seq_AML-cells_Mouse1.52809826
69* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.51026532
70OCT4_18555785_Chip-Seq_ESCs_Mouse1.49901294
71KLF4_18555785_Chip-Seq_ESCs_Mouse1.49591754
72NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.48350425
73Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.46626898
74CTCF_18555785_Chip-Seq_ESCs_Mouse1.45881645
75GATA1_22025678_ChIP-Seq_K562_Human1.45473595
76DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.44989001
77CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.43984245
78TP63_19390658_ChIP-ChIP_HaCaT_Human1.42797758
79GATA2_22383799_ChIP-Seq_G1ME_Mouse1.42237516
80EZH2_22144423_ChIP-Seq_EOC_Human1.42232799
81CRX_20693478_ChIP-Seq_RETINA_Mouse1.41099465
82LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.40358405
83SRF_21415370_ChIP-Seq_HL-1_Mouse1.40242383
84RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.39475888
85IRF1_19129219_ChIP-ChIP_H3396_Human1.37655464
86ERG_20887958_ChIP-Seq_HPC-7_Mouse1.37000984
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36365983
88MAF_26560356_Chip-Seq_TH2_Human1.34759984
89SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.34717237
90P300_19829295_ChIP-Seq_ESCs_Human1.34078595
91OCT4_21477851_ChIP-Seq_ESCs_Mouse1.33200022
92GABP_17652178_ChIP-ChIP_JURKAT_Human1.32180989
93STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.31199523
94TAL1_26923725_Chip-Seq_HPCs_Mouse1.30697988
95RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.29542642
96* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.28949200
97STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.28650610
98BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.27153261
99PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27067574
100FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.26474854
101GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24880270
102VDR_22108803_ChIP-Seq_LS180_Human1.24408409
103HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23540741
104SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23406946
105SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.23301334
106HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20971455
107SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.20056892
108MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19402926
109CBX2_27304074_Chip-Seq_ESCs_Mouse1.18427267
110STAT4_19710469_ChIP-ChIP_TH1__Mouse1.15598976
111SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14767087
112RNF2_27304074_Chip-Seq_NSC_Mouse1.12558696
113SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12476452
114SPI1_23547873_ChIP-Seq_NB4_Human1.11079218
115IRF8_27001747_Chip-Seq_BMDM_Mouse1.10967943
116EWS_26573619_Chip-Seq_HEK293_Human1.08945326
117KAP1_22055183_ChIP-Seq_ESCs_Mouse1.08468004
118CIITA_25753668_ChIP-Seq_RAJI_Human1.08461820
119VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.07925520
120EGR1_23403033_ChIP-Seq_LIVER_Mouse1.07295305
121GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07239682
122RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07149754
123SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05853788
124SMRT_27268052_Chip-Seq_Bcells_Human1.05135997
125PU_27001747_Chip-Seq_BMDM_Mouse1.04562454
126PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04170243
127* GATA1_19941826_ChIP-Seq_K562_Human1.03992874
128HOXB4_20404135_ChIP-ChIP_EML_Mouse1.03211850
129TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02908236
130FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01840591
131VDR_23849224_ChIP-Seq_CD4+_Human1.01179745
132CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.00363089
133ELK1_19687146_ChIP-ChIP_HELA_Human1.00135683
134CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.99849752
135RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.99362592
136GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99029715
137GATA1_19941827_ChIP-Seq_MEL_Mouse0.98495356
138SMAD4_21799915_ChIP-Seq_A2780_Human0.96719747
139HTT_18923047_ChIP-ChIP_STHdh_Human0.96578638
140FUS_26573619_Chip-Seq_HEK293_Human0.96004358
141FOXP3_21729870_ChIP-Seq_TREG_Human0.95609727
142RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94763808
143TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.93898480
144GATA3_26560356_Chip-Seq_TH1_Human0.93578096
145GATA2_21666600_ChIP-Seq_HMVEC_Human0.93061732
146TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.93043035
147STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.92863797
148PRDM14_20953172_ChIP-Seq_ESCs_Human0.92064178
149PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91617683
150FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90523377
151TCF7_22412390_ChIP-Seq_EML_Mouse0.88095929
152TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.86755591
153KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.86750669
154* GATA2_19941826_ChIP-Seq_K562_Human0.85149467
155GATA1_22383799_ChIP-Seq_G1ME_Mouse0.83668677
156CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.81305271
157CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81075961
158EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.79579855
159GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.78994961
160ER_23166858_ChIP-Seq_MCF-7_Human0.78654137
161* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.77811874
162NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.77780147
163FOXA1_21572438_ChIP-Seq_LNCaP_Human0.77424197
164CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77219577
165RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73414175
166CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.72550539

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.89504786
2MP0005379_endocrine/exocrine_gland_phen3.43829752
3MP0010386_abnormal_urinary_bladder3.36649095
4MP0002396_abnormal_hematopoietic_system3.23395099
5MP0006072_abnormal_retinal_apoptosis3.14605523
6MP0001986_abnormal_taste_sensitivity2.86205566
7MP0003303_peritoneal_inflammation2.83048313
8MP0005646_abnormal_pituitary_gland2.71130692
9MP0002693_abnormal_pancreas_physiology2.64325753
10MP0002638_abnormal_pupillary_reflex2.57564295
11MP0001835_abnormal_antigen_presentation2.43023976
12MP0005551_abnormal_eye_electrophysiolog2.42217577
13MP0005671_abnormal_response_to2.40478974
14MP0005253_abnormal_eye_physiology2.40103025
15MP0001188_hyperpigmentation2.30923491
16MP0005645_abnormal_hypothalamus_physiol2.30721874
17MP0002163_abnormal_gland_morphology2.23550794
18MP0003195_calcinosis2.22662137
19MP0000678_abnormal_parathyroid_gland2.18294042
20MP0001944_abnormal_pancreas_morphology2.16165361
21MP0003724_increased_susceptibility_to2.15180888
22MP0005075_abnormal_melanosome_morpholog2.12091439
23MP0002148_abnormal_hypersensitivity_rea2.05803136
24MP0000689_abnormal_spleen_morphology1.99677653
25MP0010155_abnormal_intestine_physiology1.99651424
26MP0004808_abnormal_hematopoietic_stem1.99022305
27MP0004043_abnormal_pH_regulation1.98745494
28MP0003183_abnormal_peptide_metabolism1.98306115
29MP0000015_abnormal_ear_pigmentation1.96907590
30MP0002166_altered_tumor_susceptibility1.96218142
31MP0009785_altered_susceptibility_to1.95715370
32MP0002722_abnormal_immune_system1.93457727
33MP0000703_abnormal_thymus_morphology1.93137637
34MP0001502_abnormal_circadian_rhythm1.80188472
35MP0005220_abnormal_exocrine_pancreas1.78621528
36MP0003300_gastrointestinal_ulcer1.74686860
37MP0004782_abnormal_surfactant_physiolog1.73565431
38MP0005000_abnormal_immune_tolerance1.72317080
39MP0001545_abnormal_hematopoietic_system1.71017455
40MP0005397_hematopoietic_system_phenotyp1.71017455
41MP0002277_abnormal_respiratory_mucosa1.67583383
42MP0001873_stomach_inflammation1.65108436
43MP0005174_abnormal_tail_pigmentation1.58809774
44MP0009278_abnormal_bone_marrow1.58764139
45MP0003656_abnormal_erythrocyte_physiolo1.58727822
46MP0003866_abnormal_defecation1.56792448
47MP0002877_abnormal_melanocyte_morpholog1.52311052
48MP0002876_abnormal_thyroid_physiology1.47696795
49MP0001790_abnormal_immune_system1.46804064
50MP0005387_immune_system_phenotype1.46804064
51MP0005310_abnormal_salivary_gland1.46501455
52MP0001533_abnormal_skeleton_physiology1.45757647
53MP0005025_abnormal_response_to1.42779125
54MP0001764_abnormal_homeostasis1.42201971
55MP0002006_tumorigenesis1.41577976
56MP0003172_abnormal_lysosome_physiology1.40437791
57MP0008058_abnormal_DNA_repair1.38747221
58MP0002723_abnormal_immune_serum1.38682510
59MP0000013_abnormal_adipose_tissue1.37326242
60MP0002102_abnormal_ear_morphology1.36243704
61MP0009697_abnormal_copulation1.35456959
62MP0002132_abnormal_respiratory_system1.35397469
63MP0003763_abnormal_thymus_physiology1.32709955
64MP0002419_abnormal_innate_immunity1.32397445
65MP0008057_abnormal_DNA_replication1.32128049
66MP0003436_decreased_susceptibility_to1.31037019
67MP0000631_abnormal_neuroendocrine_gland1.29558593
68MP0003011_delayed_dark_adaptation1.24210313
69MP0001800_abnormal_humoral_immune1.23607714
70MP0001324_abnormal_eye_pigmentation1.19614953
71MP0001819_abnormal_immune_cell1.18602046
72MP0005084_abnormal_gallbladder_morpholo1.18562585
73MP0002420_abnormal_adaptive_immunity1.17330118
74MP0002452_abnormal_antigen_presenting1.16347992
75MP0004883_abnormal_blood_vessel1.14928832
76MP0004947_skin_inflammation1.12817972
77MP0002078_abnormal_glucose_homeostasis1.12741938
78MP0003787_abnormal_imprinting1.08997101
79MP0004147_increased_porphyrin_level1.07074975
80MP0001984_abnormal_olfaction1.06166632
81MP0000566_synostosis1.05181695
82MP0008995_early_reproductive_senescence1.03416515
83MP0000613_abnormal_salivary_gland1.03327141
84MP0005257_abnormal_intraocular_pressure1.01291640
85MP0002938_white_spotting1.01216982
86MP0000681_abnormal_thyroid_gland1.00063772
87MP0003828_pulmonary_edema0.99478533
88MP0002928_abnormal_bile_duct0.98664675
89MP0005464_abnormal_platelet_physiology0.98654726
90MP0001851_eye_inflammation0.97783868
91MP0001663_abnormal_digestive_system0.95432472
92MP0002095_abnormal_skin_pigmentation0.94313813
93MP0000685_abnormal_immune_system0.94026489
94MP0003868_abnormal_feces_composition0.93815628
95MP0002398_abnormal_bone_marrow0.90732645
96MP0009764_decreased_sensitivity_to0.89789322
97MP0005166_decreased_susceptibility_to0.89633450
98MP0000716_abnormal_immune_system0.89263519
99MP0005423_abnormal_somatic_nervous0.88997357
100MP0000858_altered_metastatic_potential0.88123768
101MP0003191_abnormal_cellular_cholesterol0.88029026
102MP0005391_vision/eye_phenotype0.87391174
103MP0003045_fibrosis0.87363569
104MP0009763_increased_sensitivity_to0.87311283
105MP0002933_joint_inflammation0.87161591
106MP0009765_abnormal_xenobiotic_induced0.87118246
107MP0009333_abnormal_splenocyte_physiolog0.86796495
108MP0001186_pigmentation_phenotype0.86583872
109MP0002019_abnormal_tumor_incidence0.86270372
110MP0006082_CNS_inflammation0.85931386
111MP0005409_darkened_coat_color0.85706886
112MP0008007_abnormal_cellular_replicative0.83573381
113MP0008469_abnormal_protein_level0.80785521
114MP0001845_abnormal_inflammatory_respons0.80347959
115MP0002998_abnormal_bone_remodeling0.79779626
116MP0003880_abnormal_central_pattern0.79644257
117MP0001853_heart_inflammation0.79146476
118MP0003448_altered_tumor_morphology0.79109870
119MP0004381_abnormal_hair_follicle0.78757023
120MP0006276_abnormal_autonomic_nervous0.78450206
121MP0002909_abnormal_adrenal_gland0.77928163
122MP0003136_yellow_coat_color0.77747396
123MP0005164_abnormal_response_to0.77650002
124MP0002138_abnormal_hepatobiliary_system0.77055748
125MP0002009_preneoplasia0.76997203
126MP0008961_abnormal_basal_metabolism0.75750116
127MP0002405_respiratory_system_inflammati0.75313331
128MP0003075_altered_response_to0.74592130
129MP0003786_premature_aging0.74535824
130MP0000490_abnormal_crypts_of0.73403711
131MP0003953_abnormal_hormone_level0.71917781
132MP0001765_abnormal_ion_homeostasis0.71811863
133MP0000538_abnormal_urinary_bladder0.70982032
134MP0005535_abnormal_body_temperature0.69844769
135MP0000465_gastrointestinal_hemorrhage0.69762682
136MP0008877_abnormal_DNA_methylation0.68243270
137MP0002429_abnormal_blood_cell0.67794874
138MP0005195_abnormal_posterior_eye0.67200006
139MP0000372_irregular_coat_pigmentation0.66443352
140MP0003252_abnormal_bile_duct0.66012836
141MP0003806_abnormal_nucleotide_metabolis0.65995282
142MP0003941_abnormal_skin_development0.65271954
143MP0006054_spinal_hemorrhage0.64970042
144MP0005390_skeleton_phenotype0.64260862
145MP0000249_abnormal_blood_vessel0.64008616
146MP0003943_abnormal_hepatobiliary_system0.61906546
147MP0000569_abnormal_digit_pigmentation0.56228372
148MP0008873_increased_physiological_sensi0.53957488
149MP0003795_abnormal_bone_structure0.52243478
150MP0001664_abnormal_digestion0.50683704

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.98212205
2Panhypogammaglobulinemia (HP:0003139)4.76491378
3T lymphocytopenia (HP:0005403)4.67230524
4Congenital stationary night blindness (HP:0007642)4.44959761
5Abnormality of T cell number (HP:0011839)4.39795175
6Stomatitis (HP:0010280)4.20973321
7Recurrent fungal infections (HP:0002841)4.19428589
8Eczematoid dermatitis (HP:0000976)4.00732854
9* Absent rod-and cone-mediated responses on ERG (HP:0007688)3.96955903
10Severe combined immunodeficiency (HP:0004430)3.95067959
11Symptomatic seizures (HP:0011145)3.93228341
12Recurrent viral infections (HP:0004429)3.74265540
13* Abnormal rod and cone electroretinograms (HP:0008323)3.74225242
14Abnormality of T cells (HP:0002843)3.71053778
15Type I transferrin isoform profile (HP:0003642)3.68752477
16Decreased central vision (HP:0007663)3.65383673
17Hypoglycemic seizures (HP:0002173)3.65302424
18Aplasia/Hypoplasia of the fovea (HP:0008060)3.51549252
19Hypoplasia of the fovea (HP:0007750)3.51549252
20Abnormality of B cell number (HP:0010975)3.50615319
21Hyperinsulinemic hypoglycemia (HP:0000825)3.49477338
22Agammaglobulinemia (HP:0004432)3.48427745
23Recurrent skin infections (HP:0001581)3.42308217
24Autoimmune hemolytic anemia (HP:0001890)3.37803403
25Severe visual impairment (HP:0001141)3.27543903
26Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.25426258
27B lymphocytopenia (HP:0010976)3.23443444
28Vasculitis (HP:0002633)3.22250772
29Abnormality of eosinophils (HP:0001879)3.21304630
30Acute lymphatic leukemia (HP:0006721)3.20622664
31Gastrointestinal infarctions (HP:0005244)3.20482284
32Chronic obstructive pulmonary disease (HP:0006510)3.20069950
33Obstructive lung disease (HP:0006536)3.20069950
34Bony spicule pigmentary retinopathy (HP:0007737)3.19167820
35Thyroiditis (HP:0100646)3.16210238
36Spontaneous hematomas (HP:0007420)3.14669219
37True hermaphroditism (HP:0010459)3.13757652
38Leukocytosis (HP:0001974)3.11735598
39Optic neuritis (HP:0100653)3.09056722
40Retrobulbar optic neuritis (HP:0100654)3.09056722
41Dynein arm defect of respiratory motile cilia (HP:0012255)3.06857960
42Absent/shortened dynein arms (HP:0200106)3.06857960
43Decreased circulating renin level (HP:0003351)3.05746395
44Combined immunodeficiency (HP:0005387)3.02337333
45Pendular nystagmus (HP:0012043)3.01730823
46Abnormality of macrophages (HP:0004311)3.01330826
47Granulocytopenia (HP:0001913)2.98336438
48Abnormality of the prostate (HP:0008775)2.95488441
49Mediastinal lymphadenopathy (HP:0100721)2.95248671
50IgG deficiency (HP:0004315)2.94905952
51Abnormality of the fovea (HP:0000493)2.94275425
52Reduced antithrombin III activity (HP:0001976)2.91472997
53Abnormality of T cell physiology (HP:0011840)2.89558210
54Abnormal protein glycosylation (HP:0012346)2.86950409
55Abnormal glycosylation (HP:0012345)2.86950409
56Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.86950409
57Abnormal protein N-linked glycosylation (HP:0012347)2.86950409
58Eosinophilia (HP:0001880)2.86353685
59Myositis (HP:0100614)2.83565796
60Epistaxis (HP:0000421)2.82710164
61Chronic otitis media (HP:0000389)2.81824666
62Pustule (HP:0200039)2.80421431
63Hypothermia (HP:0002045)2.78477749
64Hypoplasia of the thymus (HP:0000778)2.78009131
65Recurrent bronchitis (HP:0002837)2.77197409
66Osteomalacia (HP:0002749)2.75293819
67Autoimmune thrombocytopenia (HP:0001973)2.74538095
68Pulmonary infiltrates (HP:0002113)2.71972434
69Hemoptysis (HP:0002105)2.71934040
70Inflammation of the large intestine (HP:0002037)2.70831048
71* Attenuation of retinal blood vessels (HP:0007843)2.70391683
72Chest pain (HP:0100749)2.68031658
73Gastrointestinal inflammation (HP:0004386)2.64163513
74Abnormality of calcium-phosphate metabolism (HP:0100530)2.62395324
75Pancreatic cysts (HP:0001737)2.59315139
76Pulmonary embolism (HP:0002204)2.59269594
77Pancreatic fibrosis (HP:0100732)2.57810387
78Orchitis (HP:0100796)2.57718478
79Dyschromatopsia (HP:0007641)2.57537115
80Chromosomal breakage induced by crosslinking agents (HP:0003221)2.55671101
81Abnormality of macular pigmentation (HP:0008002)2.53535546
82Recurrent sinusitis (HP:0011108)2.50475255
83IgM deficiency (HP:0002850)2.50128821
84Papilledema (HP:0001085)2.47755873
85Urticaria (HP:0001025)2.46487282
86Vacuolated lymphocytes (HP:0001922)2.46399209
87Abnormal delayed hypersensitivity skin test (HP:0002963)2.42962482
88Arterial thrombosis (HP:0004420)2.41011524
89Chromsome breakage (HP:0040012)2.37943528
90Recurrent gram-negative bacterial infections (HP:0005420)2.37776909
91Abnormal ciliary motility (HP:0012262)2.35159414
92Gingival bleeding (HP:0000225)2.34629211
93Hypoglycemic coma (HP:0001325)2.34312335
94Intestinal atresia (HP:0011100)2.33434062
95Insulin-resistant diabetes mellitus (HP:0000831)2.32225408
96Renal cortical cysts (HP:0000803)2.30089964
97Congenital sensorineural hearing impairment (HP:0008527)2.29365510
98Increased IgE level (HP:0003212)2.29220524
99Lymphopenia (HP:0001888)2.28915211
100Increased corneal curvature (HP:0100692)2.28751199
101Keratoconus (HP:0000563)2.28751199
102Abnormal respiratory motile cilium physiology (HP:0012261)2.26808992
103Colitis (HP:0002583)2.26075513
104Bronchiectasis (HP:0002110)2.24649650
105Microvesicular hepatic steatosis (HP:0001414)2.24217070
106Thrombocytosis (HP:0001894)2.24161792
107Hypochromic microcytic anemia (HP:0004840)2.21849670
108Hypoproteinemia (HP:0003075)2.21028009
109Chronic diarrhea (HP:0002028)2.20513395
110Cellulitis (HP:0100658)2.19278749
111Microcytic anemia (HP:0001935)2.19182062
112Petechiae (HP:0000967)2.18011070
113Abnormal respiratory motile cilium morphology (HP:0005938)2.17863683
114Abnormal respiratory epithelium morphology (HP:0012253)2.17863683
115Central scotoma (HP:0000603)2.17632285
116Conjugated hyperbilirubinemia (HP:0002908)2.16726149
117Bronchitis (HP:0012387)2.14555090
118Chronic sinusitis (HP:0011109)2.12726631
119Episodic fever (HP:0001954)2.11959434
120Abolished electroretinogram (ERG) (HP:0000550)2.11741104
121Hyperglycemia (HP:0003074)2.11619550
122Lymphoma (HP:0002665)2.11271128
123Abnormality of cells of the lymphoid lineage (HP:0012140)2.10607920
124Anorexia (HP:0002039)2.09835165
125Aplasia/Hypoplasia of the thymus (HP:0010515)2.09600943
126Albinism (HP:0001022)2.08615933
127* Photophobia (HP:0000613)2.08010332
128Aplastic anemia (HP:0001915)2.07051041
129Acute myeloid leukemia (HP:0004808)2.06685082
130Acute hepatic failure (HP:0006554)2.04086051
131Cystic liver disease (HP:0006706)2.03369592
132Medial flaring of the eyebrow (HP:0010747)2.03096816
133Abnormality of the pleura (HP:0002103)2.03044973
134Encephalitis (HP:0002383)2.02681204
135Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.01912770
136Aplasia/Hypoplasia of the macula (HP:0008059)2.01459848
137Sepsis (HP:0100806)2.00938294
138Skin rash (HP:0000988)2.00270609
139Hypochromic anemia (HP:0001931)1.99895341
140Metaphyseal dysplasia (HP:0100255)1.99779123
141Hypergammaglobulinemia (HP:0010702)1.97626745
142Generalized aminoaciduria (HP:0002909)1.96520439
143Nasal polyposis (HP:0100582)1.95445935
144Joint hemorrhage (HP:0005261)1.94070612
145Meningitis (HP:0001287)1.91858619
146Generalized hypopigmentation of hair (HP:0011358)1.90684696
147Keratoconjunctivitis sicca (HP:0001097)1.90377062
148Pigmentary retinal degeneration (HP:0001146)1.89075422
149Recurrent abscess formation (HP:0002722)1.88769011
150Dysostosis multiplex (HP:0000943)1.85882856
151Prolonged partial thromboplastin time (HP:0003645)1.85741135
15211 pairs of ribs (HP:0000878)1.84719165
153Fair hair (HP:0002286)1.84366995
154* Type II diabetes mellitus (HP:0005978)1.84313754
155Congenital hepatic fibrosis (HP:0002612)1.84206584
156* Constricted visual fields (HP:0001133)1.83608335
157Increased hepatocellular lipid droplets (HP:0006565)1.82500492
158Pancreatic islet-cell hyperplasia (HP:0004510)1.79929656
159Chronic hepatic failure (HP:0100626)1.79251564
160Recurrent bacterial skin infections (HP:0005406)1.78197717
161Prominent metopic ridge (HP:0005487)1.77633210
162Retinitis pigmentosa (HP:0000510)1.76783533
163Abnormality of endocrine pancreas physiology (HP:0012093)1.75567577
164Abnormality of the pancreatic islet cells (HP:0006476)1.75567577
165Neutropenia (HP:0001875)1.74871057
166Prolonged bleeding time (HP:0003010)1.74448373
167Recurrent cutaneous fungal infections (HP:0011370)1.73925539
168Chronic mucocutaneous candidiasis (HP:0002728)1.73925539
1693-Methylglutaconic aciduria (HP:0003535)1.73736423
170Clubbing of toes (HP:0100760)1.73440889
171Renal Fanconi syndrome (HP:0001994)1.72258461
172Nephrogenic diabetes insipidus (HP:0009806)1.72217855
173Limb hypertonia (HP:0002509)1.72049141
174Exertional dyspnea (HP:0002875)1.70754264
175Keratoconjunctivitis (HP:0001096)1.70578626
176Abnormality of midbrain morphology (HP:0002418)1.69681869
177Molar tooth sign on MRI (HP:0002419)1.69681869
178Cone-rod dystrophy (HP:0000548)1.68356633
179Febrile seizures (HP:0002373)1.68001785
180Increased IgM level (HP:0003496)1.67285359
181Abnormality of renal resorption (HP:0011038)1.67042091
182Abnormality of polysaccharide metabolism (HP:0011012)1.66124588
183Abnormality of glycosaminoglycan metabolism (HP:0004371)1.66124588
184Abnormality of mucopolysaccharide metabolism (HP:0011020)1.66124588
185Mucopolysacchariduria (HP:0008155)1.65357271

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR4.34285000
2IRAK33.66530155
3IRAK43.14873766
4MAPK153.08436630
5STK162.91137435
6PASK2.56102581
7TNIK2.38296013
8TAOK32.32747104
9TXK2.27545668
10CDK82.22378624
11MAP2K32.22059190
12MAP3K142.13704062
13ADRBK22.04559801
14GRK61.94472890
15TEC1.92468538
16BCKDK1.89816593
17MATK1.86349445
18TRPM71.84429195
19PIK3CG1.84269807
20CDK191.83125007
21GRK11.82536124
22BMPR21.74826557
23IRAK11.72079554
24WNK31.68238914
25CASK1.65406491
26GRK71.63564140
27BMPR1B1.61114251
28EIF2AK21.55395401
29CSF1R1.53867046
30HCK1.52877145
31HIPK21.52151730
32ZAK1.35229885
33SIK31.32779024
34NLK1.32117739
35BTK1.30133661
36VRK11.28860075
37MAP2K71.26556403
38JAK31.26176251
39EPHA31.22298808
40KIT1.21107460
41IRAK21.20626378
42YES11.18835428
43BLK1.17914499
44IKBKE1.17808780
45EIF2AK31.16189746
46PRKCQ1.12153816
47MARK31.09466439
48BRSK21.06446485
49CDK31.04760764
50NTRK31.02853026
51FLT31.02843229
52IKBKB1.02377230
53SGK20.98593199
54JAK20.94985632
55MUSK0.93280864
56SCYL20.92285199
57CDK60.90732845
58ERN10.90441417
59ITK0.83972363
60SYK0.83872250
61CDK90.80521766
62NUAK10.79226813
63CHUK0.78567537
64TESK20.77110303
65PINK10.77064882
66MAPK70.76973334
67MAPK130.76597299
68NME20.76585762
69LYN0.76550628
70CAMKK20.74455954
71DYRK30.74088736
72PDK10.73720332
73RIPK40.72794725
74ERBB30.70761685
75MAP3K60.70520205
76TNK20.69796836
77FGFR30.69167343
78TIE10.67959629
79KDR0.60975116
80MAP3K70.60472256
81MAP3K130.59576891
82PIM20.57420994
83PRKD20.57356093
84MKNK20.55958217
85PRPF4B0.55897439
86MAP4K10.55641146
87AKT30.53572376
88BRD40.53403156
89MAP3K30.53151192
90ZAP700.52746190
91PLK40.52165928
92CSK0.51001083
93ABL10.50962087
94MAP4K20.50268191
95MAPK120.50008763
96MAP2K60.49686116
97FRK0.48932478
98LCK0.48672595
99JAK10.48023886
100MST40.47972288
101TGFBR20.47253485
102RPS6KA50.46433708
103FGR0.45938592
104FYN0.45563468
105STK100.45480668
106PRKCH0.45096453
107ATR0.43965523
108NEK60.43642172
109SRPK10.43427845
110TBK10.43236037
111MAP3K10.42806519
112MAP2K20.42524062
113MAP3K50.42293070
114FES0.42151413
115WNK40.41811665
116RPS6KA60.41717593
117CLK10.41419087
118CDK40.41272532
119DAPK20.40873569
120RPS6KL10.40604989
121RPS6KC10.40604989
122PRKCE0.40551702
123RPS6KA40.40345329
124CAMKK10.39822163
125TYK20.39755498
126SGK4940.39364999
127SGK2230.39364999
128CAMK10.39155521
129RPS6KB10.38406913
130MAP3K110.38313248
131STK38L0.37503390
132MAPK40.36983089
133STK110.35734252
134SGK30.35536795
135RPS6KB20.34520643
136WNK10.33428005
137MKNK10.33319214
138TLK10.33003252
139BRAF0.32920805
140OXSR10.32740087
141RPS6KA20.32575813
142PDPK10.31794817
143INSR0.31582470
144PIM10.31286705
145ACVR1B0.31145739
146PRKCD0.30979219
147PTK2B0.30804231
148MAPK30.30597322
149MAPK110.28090501

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049506.03418383
2Protein export_Homo sapiens_hsa030605.38594117
3Phototransduction_Homo sapiens_hsa047443.49149399
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.31288630
5B cell receptor signaling pathway_Homo sapiens_hsa046622.24968803
6T cell receptor signaling pathway_Homo sapiens_hsa046602.24004050
7Type I diabetes mellitus_Homo sapiens_hsa049402.17074816
8Graft-versus-host disease_Homo sapiens_hsa053322.02104308
9Other glycan degradation_Homo sapiens_hsa005111.98331237
10SNARE interactions in vesicular transport_Homo sapiens_hsa041301.88480445
11Insulin secretion_Homo sapiens_hsa049111.70379608
12Fanconi anemia pathway_Homo sapiens_hsa034601.64250294
13Malaria_Homo sapiens_hsa051441.60308354
14Allograft rejection_Homo sapiens_hsa053301.58517082
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.53793875
16Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.52120233
17Platelet activation_Homo sapiens_hsa046111.45584367
18Non-homologous end-joining_Homo sapiens_hsa034501.44886438
19Basal transcription factors_Homo sapiens_hsa030221.44801530
20Viral myocarditis_Homo sapiens_hsa054161.44783948
21Glycosaminoglycan degradation_Homo sapiens_hsa005311.40905292
22Acute myeloid leukemia_Homo sapiens_hsa052211.38181846
23Homologous recombination_Homo sapiens_hsa034401.37959632
24African trypanosomiasis_Homo sapiens_hsa051431.36122514
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.33262692
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.31942795
27Hematopoietic cell lineage_Homo sapiens_hsa046401.31879985
28Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.31743778
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.31507890
30Toxoplasmosis_Homo sapiens_hsa051451.30566580
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.28982136
32Autoimmune thyroid disease_Homo sapiens_hsa053201.27663963
33RNA polymerase_Homo sapiens_hsa030201.24630041
34Taste transduction_Homo sapiens_hsa047421.20381751
35Sphingolipid metabolism_Homo sapiens_hsa006001.18981423
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17839036
37Measles_Homo sapiens_hsa051621.17066202
38Regulation of autophagy_Homo sapiens_hsa041401.15314013
39Primary immunodeficiency_Homo sapiens_hsa053401.14725239
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.14622640
41Leishmaniasis_Homo sapiens_hsa051401.13786840
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10839381
43Pyrimidine metabolism_Homo sapiens_hsa002401.08856860
44N-Glycan biosynthesis_Homo sapiens_hsa005101.07665237
45ABC transporters_Homo sapiens_hsa020101.07664509
46Rheumatoid arthritis_Homo sapiens_hsa053231.06944166
47Circadian rhythm_Homo sapiens_hsa047101.05925191
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05067671
49Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.01860875
50RNA degradation_Homo sapiens_hsa030181.00757211
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95987113
52Herpes simplex infection_Homo sapiens_hsa051680.91857586
53Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.90541952
54Folate biosynthesis_Homo sapiens_hsa007900.90028555
55Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.88604589
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.88357309
57Antigen processing and presentation_Homo sapiens_hsa046120.88206820
58Toll-like receptor signaling pathway_Homo sapiens_hsa046200.88019629
59Mismatch repair_Homo sapiens_hsa034300.85609529
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85222547
61Base excision repair_Homo sapiens_hsa034100.85196300
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85099026
63NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85027198
64Purine metabolism_Homo sapiens_hsa002300.84643771
65Vibrio cholerae infection_Homo sapiens_hsa051100.84533342
66Asthma_Homo sapiens_hsa053100.80407478
67Serotonergic synapse_Homo sapiens_hsa047260.79509285
68Arachidonic acid metabolism_Homo sapiens_hsa005900.79277154
69Non-small cell lung cancer_Homo sapiens_hsa052230.78366495
70Linoleic acid metabolism_Homo sapiens_hsa005910.75649280
71Hepatitis C_Homo sapiens_hsa051600.75270592
72Jak-STAT signaling pathway_Homo sapiens_hsa046300.74805099
73Lysosome_Homo sapiens_hsa041420.73384433
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.72263698
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.71265475
76Morphine addiction_Homo sapiens_hsa050320.70032619
77Pertussis_Homo sapiens_hsa051330.68535622
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68295069
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67689267
80Pancreatic cancer_Homo sapiens_hsa052120.67052235
81Legionellosis_Homo sapiens_hsa051340.65464815
82Epstein-Barr virus infection_Homo sapiens_hsa051690.65032233
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63027747
84Selenocompound metabolism_Homo sapiens_hsa004500.61927095
85Nicotine addiction_Homo sapiens_hsa050330.61814137
86DNA replication_Homo sapiens_hsa030300.61442048
87Sulfur metabolism_Homo sapiens_hsa009200.61432368
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61048095
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.59141500
90HTLV-I infection_Homo sapiens_hsa051660.58414825
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.57370686
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56007152
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55998583
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54808768
95Ribosome_Homo sapiens_hsa030100.54357327
96Type II diabetes mellitus_Homo sapiens_hsa049300.53927772
97Influenza A_Homo sapiens_hsa051640.53411374
98Chronic myeloid leukemia_Homo sapiens_hsa052200.52676114
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.52119541
100Salmonella infection_Homo sapiens_hsa051320.51662750
101Dorso-ventral axis formation_Homo sapiens_hsa043200.51225572
102Circadian entrainment_Homo sapiens_hsa047130.51218241
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.50371756
104Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50057782
105Histidine metabolism_Homo sapiens_hsa003400.49132764
106Staphylococcus aureus infection_Homo sapiens_hsa051500.48968665
107Cocaine addiction_Homo sapiens_hsa050300.48096985
108Nucleotide excision repair_Homo sapiens_hsa034200.45632464
109Apoptosis_Homo sapiens_hsa042100.45273752
110VEGF signaling pathway_Homo sapiens_hsa043700.44562320
111Inositol phosphate metabolism_Homo sapiens_hsa005620.44473493
112Viral carcinogenesis_Homo sapiens_hsa052030.44282018
113Shigellosis_Homo sapiens_hsa051310.43389790
114Renin secretion_Homo sapiens_hsa049240.43252803
115Systemic lupus erythematosus_Homo sapiens_hsa053220.42758868
116Osteoclast differentiation_Homo sapiens_hsa043800.42589733
117Tuberculosis_Homo sapiens_hsa051520.41767553
118Chemokine signaling pathway_Homo sapiens_hsa040620.41021322
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41007442
120Prolactin signaling pathway_Homo sapiens_hsa049170.40803443
121TNF signaling pathway_Homo sapiens_hsa046680.40427787
122Peroxisome_Homo sapiens_hsa041460.40135962
123Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40027440
124Salivary secretion_Homo sapiens_hsa049700.39295618
125Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38217088
126Amphetamine addiction_Homo sapiens_hsa050310.37040251
127Phagosome_Homo sapiens_hsa041450.36699763
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36419142
129Caffeine metabolism_Homo sapiens_hsa002320.35945912
130Insulin resistance_Homo sapiens_hsa049310.35472866
131Ether lipid metabolism_Homo sapiens_hsa005650.35419312
132GABAergic synapse_Homo sapiens_hsa047270.33986481
133Olfactory transduction_Homo sapiens_hsa047400.33620976
134FoxO signaling pathway_Homo sapiens_hsa040680.32926783
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.31489494
136Ovarian steroidogenesis_Homo sapiens_hsa049130.28594304
137Choline metabolism in cancer_Homo sapiens_hsa052310.28130865
138Collecting duct acid secretion_Homo sapiens_hsa049660.27431598
139One carbon pool by folate_Homo sapiens_hsa006700.27079641
140Hepatitis B_Homo sapiens_hsa051610.26308119
141MAPK signaling pathway_Homo sapiens_hsa040100.25596147
142Nitrogen metabolism_Homo sapiens_hsa009100.25487591
143Adipocytokine signaling pathway_Homo sapiens_hsa049200.21503663
144Renin-angiotensin system_Homo sapiens_hsa046140.21160889
145mTOR signaling pathway_Homo sapiens_hsa041500.20117795
146Vascular smooth muscle contraction_Homo sapiens_hsa042700.19719623
147Pancreatic secretion_Homo sapiens_hsa049720.18445472
148Oxytocin signaling pathway_Homo sapiens_hsa049210.18091342

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »