CERS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)7.98528077
2axon ensheathment in central nervous system (GO:0032291)7.98528077
3fatty acid elongation (GO:0030497)7.50350602
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.41571689
5L-phenylalanine catabolic process (GO:0006559)6.41571689
6L-phenylalanine metabolic process (GO:0006558)5.84350835
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.84350835
8cholesterol biosynthetic process (GO:0006695)5.14502811
9COPI coating of Golgi vesicle (GO:0048205)4.98707364
10Golgi transport vesicle coating (GO:0048200)4.98707364
11aromatic amino acid family catabolic process (GO:0009074)4.81156017
12axon ensheathment (GO:0008366)4.69657440
13ensheathment of neurons (GO:0007272)4.69657440
14myelination (GO:0042552)4.63056780
15long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.61596734
16urea metabolic process (GO:0019627)4.61444512
17sterol biosynthetic process (GO:0016126)4.53521681
18heme transport (GO:0015886)4.52140439
19very long-chain fatty acid metabolic process (GO:0000038)4.45642557
20fatty-acyl-CoA biosynthetic process (GO:0046949)4.44473273
21urea cycle (GO:0000050)4.44128024
22glyoxylate metabolic process (GO:0046487)4.18627532
23alpha-linolenic acid metabolic process (GO:0036109)4.15383982
24bile acid biosynthetic process (GO:0006699)4.12396214
25nitrogen cycle metabolic process (GO:0071941)4.12075162
26myelin maintenance (GO:0043217)4.12007502
27amyloid precursor protein metabolic process (GO:0042982)4.07856087
28creatine metabolic process (GO:0006600)4.05360016
29L-serine metabolic process (GO:0006563)4.03556896
30fatty-acyl-CoA metabolic process (GO:0035337)4.00949015
31amyloid precursor protein catabolic process (GO:0042987)3.97683125
32long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.89214132
33cysteine metabolic process (GO:0006534)3.88620754
34acyl-CoA biosynthetic process (GO:0071616)3.86043586
35thioester biosynthetic process (GO:0035384)3.86043586
36proline biosynthetic process (GO:0006561)3.79879339
37fibrinolysis (GO:0042730)3.76087141
38protein retention in ER lumen (GO:0006621)3.73884359
39maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.72229127
40serine family amino acid biosynthetic process (GO:0009070)3.71125610
41response to methylmercury (GO:0051597)3.69147513
42cofactor catabolic process (GO:0051187)3.58752422
43plasma lipoprotein particle clearance (GO:0034381)3.54637999
44regulation of lipoprotein metabolic process (GO:0050746)3.53034269
45bile acid metabolic process (GO:0008206)3.50514905
46proline metabolic process (GO:0006560)3.50434216
47triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.47056040
48tyrosine metabolic process (GO:0006570)3.46975398
49ethanol oxidation (GO:0006069)3.46143855
50thioester metabolic process (GO:0035383)3.45235914
51acyl-CoA metabolic process (GO:0006637)3.45235914
52regulation of cholesterol metabolic process (GO:0090181)3.44974308
53coenzyme catabolic process (GO:0009109)3.42304092
54peptidyl-glutamic acid carboxylation (GO:0017187)3.42046313
55protein carboxylation (GO:0018214)3.42046313
56aromatic amino acid family metabolic process (GO:0009072)3.42001746
57indole-containing compound catabolic process (GO:0042436)3.40968815
58indolalkylamine catabolic process (GO:0046218)3.40968815
59tryptophan catabolic process (GO:0006569)3.40968815
60aldehyde catabolic process (GO:0046185)3.39313373
61long-chain fatty acid biosynthetic process (GO:0042759)3.38543685
62opsonization (GO:0008228)3.38423054
63positive regulation of cellular amine metabolic process (GO:0033240)3.37790602
64cholesterol metabolic process (GO:0008203)3.37702627
65positive regulation of triglyceride lipase activity (GO:0061365)3.37484334
66positive regulation of lipoprotein lipase activity (GO:0051006)3.37484334
67isoprenoid biosynthetic process (GO:0008299)3.36554016
68sulfur amino acid catabolic process (GO:0000098)3.33983984
69iron coordination entity transport (GO:1901678)3.32609114
70acetyl-CoA metabolic process (GO:0006084)3.31284015
71glycerophospholipid catabolic process (GO:0046475)3.29626003
72fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.28546688
73epoxygenase P450 pathway (GO:0019373)3.28475063
74response to lipoprotein particle (GO:0055094)3.25357546
75pentose-phosphate shunt (GO:0006098)3.24967539
76negative regulation of cholesterol transport (GO:0032375)3.24129730
77negative regulation of sterol transport (GO:0032372)3.24129730
78nucleotide transmembrane transport (GO:1901679)3.22899201
79negative regulation of fibrinolysis (GO:0051918)3.22833537
80tryptophan metabolic process (GO:0006568)3.21851142
81phospholipid efflux (GO:0033700)3.21557651
82kynurenine metabolic process (GO:0070189)3.18005901
83glucose 6-phosphate metabolic process (GO:0051156)3.17246066
84retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.17128791
85response to mercury ion (GO:0046689)3.16471380
86regulation of plasminogen activation (GO:0010755)3.16033470
87short-chain fatty acid metabolic process (GO:0046459)3.15915626
88sterol metabolic process (GO:0016125)3.14034747
89blood coagulation, intrinsic pathway (GO:0007597)3.11765424
90regulation of triglyceride catabolic process (GO:0010896)3.11076839
91regulation of glucose import in response to insulin stimulus (GO:2001273)3.10693554
92complement activation, alternative pathway (GO:0006957)3.10597313
93regulation of cholesterol homeostasis (GO:2000188)3.10430212
94regulation of cholesterol biosynthetic process (GO:0045540)3.10361299
95glutamine family amino acid biosynthetic process (GO:0009084)3.09605134
96positive regulation of extracellular matrix organization (GO:1903055)3.09521707
97high-density lipoprotein particle remodeling (GO:0034375)3.07683876
98steroid biosynthetic process (GO:0006694)3.06428108
99serine family amino acid metabolic process (GO:0009069)3.04533927
100regulation of protein activation cascade (GO:2000257)3.04237832
101regulation of fibrinolysis (GO:0051917)3.02702350
102glutathione derivative metabolic process (GO:1901685)3.00369454
103glutathione derivative biosynthetic process (GO:1901687)3.00369454
104basement membrane organization (GO:0071711)3.00175374
105cholesterol efflux (GO:0033344)2.99438479
106negative regulation of fatty acid transport (GO:2000192)2.97389071
107negative regulation of fatty acid biosynthetic process (GO:0045717)2.97278971
108response to lead ion (GO:0010288)2.96072195
109negative regulation of lipid transport (GO:0032369)2.94931732
110regulation of cholesterol esterification (GO:0010872)2.94491215
111plasma lipoprotein particle assembly (GO:0034377)2.93649400
112import into cell (GO:0098657)2.92889883
113maternal placenta development (GO:0001893)2.92052990
114NADPH regeneration (GO:0006740)2.91926281
115cholesterol homeostasis (GO:0042632)2.91733384
116pinocytosis (GO:0006907)2.91327754
117ethanol metabolic process (GO:0006067)2.91078940
118negative regulation of blood coagulation (GO:0030195)2.91068566
119negative regulation of hemostasis (GO:1900047)2.91068566
120very-low-density lipoprotein particle assembly (GO:0034379)2.91025437
121pyrimidine-containing compound transmembrane transport (GO:0072531)2.90337598
122omega-hydroxylase P450 pathway (GO:0097267)2.90066381
123oligodendrocyte differentiation (GO:0048709)2.89195531
124adhesion of symbiont to host cell (GO:0044650)2.88410647
125virion attachment to host cell (GO:0019062)2.88410647
126response to nitrosative stress (GO:0051409)2.88000204
127alpha-amino acid catabolic process (GO:1901606)2.87435337
128cell-substrate adherens junction assembly (GO:0007045)2.86835909
129focal adhesion assembly (GO:0048041)2.86835909
130aspartate family amino acid catabolic process (GO:0009068)2.86650067
131sterol homeostasis (GO:0055092)2.85997728
132regulation of complement activation (GO:0030449)2.85853906
133cellular glucuronidation (GO:0052695)2.85410858
134glucose catabolic process (GO:0006007)2.84130950
135cellular ketone body metabolic process (GO:0046950)2.83876492
136drug transmembrane transport (GO:0006855)2.79292997
137protein localization to endosome (GO:0036010)2.78812578
138negative regulation of neurotransmitter secretion (GO:0046929)2.77345650
139protein-lipid complex assembly (GO:0065005)2.77256818
140COPII vesicle coating (GO:0048208)2.77113910
141triglyceride biosynthetic process (GO:0019432)2.75398009
142adherens junction assembly (GO:0034333)2.73217884
143negative regulation of coagulation (GO:0050819)2.71233062
144negative regulation of wound healing (GO:0061045)2.68351106
145regulation of early endosome to late endosome transport (GO:2000641)2.67705156
146regulation of apoptotic cell clearance (GO:2000425)2.66014221
147positive regulation of blood coagulation (GO:0030194)2.65695105
148positive regulation of hemostasis (GO:1900048)2.65695105
149acute-phase response (GO:0006953)2.62827613
150epithelial cell-cell adhesion (GO:0090136)2.62589698
151uronic acid metabolic process (GO:0006063)2.61200655
152glucuronate metabolic process (GO:0019585)2.61200655
153positive regulation of Cdc42 GTPase activity (GO:0043089)2.60035101
154activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.59775707
155protein maturation by protein folding (GO:0022417)2.58385202
156embryonic process involved in female pregnancy (GO:0060136)2.56699019
157positive regulation of coagulation (GO:0050820)2.56031962
158negative regulation of cell size (GO:0045792)2.55871584
159intestinal cholesterol absorption (GO:0030299)2.55649187
160regulation of bile acid biosynthetic process (GO:0070857)2.54035573
161cell-substrate junction assembly (GO:0007044)2.53497663
162regulation of mammary gland epithelial cell proliferation (GO:0033599)2.52162613
163regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.51895673
164macromolecular complex remodeling (GO:0034367)2.51834645
165plasma lipoprotein particle remodeling (GO:0034369)2.51834645
166protein-lipid complex remodeling (GO:0034368)2.51834645
167vesicle coating (GO:0006901)2.51602484
168positive regulation of nuclease activity (GO:0032075)2.50947839
169NADH metabolic process (GO:0006734)2.49961468
170hormone catabolic process (GO:0042447)2.49188906
171hyaluronan catabolic process (GO:0030214)2.49034537
172positive regulation of lipid catabolic process (GO:0050996)2.48910761
173cell adhesion mediated by integrin (GO:0033627)2.48310183
174desmosome organization (GO:0002934)2.46098286
175skin morphogenesis (GO:0043589)2.45500230

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.97284525
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.54637680
3EGR1_23403033_ChIP-Seq_LIVER_Mouse4.86693036
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.58917984
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.45083337
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.20520218
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.82097901
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.63155688
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.48031544
10TP63_17297297_ChIP-ChIP_HaCaT_Human3.11392281
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.09024626
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.76287482
13ZNF263_19887448_ChIP-Seq_K562_Human2.48513189
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.37785547
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.34619185
16RACK7_27058665_Chip-Seq_MCF-7_Human2.28271851
17PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.26780810
18NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.20173366
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.18875392
20E2F7_22180533_ChIP-Seq_HELA_Human2.17460199
21ELK3_25401928_ChIP-Seq_HUVEC_Human2.17324374
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.16390081
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.14289017
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.00942864
25LXR_22292898_ChIP-Seq_THP-1_Human2.00625386
26EGR1_19374776_ChIP-ChIP_THP-1_Human2.00426534
27ESR1_21235772_ChIP-Seq_MCF-7_Human1.92989651
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.92627037
29MYC_22102868_ChIP-Seq_BL_Human1.88587640
30KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.87527609
31ESR1_20079471_ChIP-ChIP_T-47D_Human1.80176339
32VDR_21846776_ChIP-Seq_THP-1_Human1.79443430
33ESR1_15608294_ChIP-ChIP_MCF-7_Human1.77933600
34PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.74308335
35SCL_19346495_ChIP-Seq_HPC-7_Human1.72628625
36IRF8_21731497_ChIP-ChIP_J774_Mouse1.70480215
37FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.67874849
38KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.67735263
39TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65450208
40KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.61837998
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.59546664
42HTT_18923047_ChIP-ChIP_STHdh_Human1.55315612
43TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53365893
44DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.53230672
45TCF7_22412390_ChIP-Seq_EML_Mouse1.53171648
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.52762608
47HIF1A_21447827_ChIP-Seq_MCF-7_Human1.52662511
48AR_21909140_ChIP-Seq_LNCAP_Human1.48112503
49GATA1_22025678_ChIP-Seq_K562_Human1.47622433
50RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.46393453
51SOX2_27498859_Chip-Seq_STOMACH_Mouse1.46314584
52SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44248551
53TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.42661705
54PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.40327504
55ATF3_27146783_Chip-Seq_COLON_Human1.39289931
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38644399
57FOXM1_23109430_ChIP-Seq_U2OS_Human1.38524399
58ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.37853695
59KLF4_18555785_ChIP-Seq_MESCs_Mouse1.36780517
60HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.36302448
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35898614
62SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.35002352
63P300_27058665_Chip-Seq_ZR-75-30cells_Human1.34634220
64VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.34468914
65BP1_19119308_ChIP-ChIP_Hs578T_Human1.32755434
66GATA1_19941826_ChIP-Seq_K562_Human1.31582622
67ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.31570684
68KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.31131030
69IRF8_22096565_ChIP-ChIP_GC-B_Human1.29261061
70FOXA2_19822575_ChIP-Seq_HepG2_Human1.28073924
71ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.27131811
72IRF8_27001747_Chip-Seq_BMDM_Mouse1.26502597
73NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.26348715
74SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.25337559
75LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.24942960
76RUNX1_27514584_Chip-Seq_MCF-7_Human1.24873029
77GATA6_25053715_ChIP-Seq_YYC3_Human1.23586395
78PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.23302582
79KDM2B_26808549_Chip-Seq_DND41_Human1.21662307
80MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.21548279
81STAT3_1855785_ChIP-Seq_MESCs_Mouse1.21266065
82HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.20765476
83TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20438282
84Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.20119283
85MYC_18555785_ChIP-Seq_MESCs_Mouse1.19885687
86SRY_22984422_ChIP-ChIP_TESTIS_Rat1.18952485
87NRF2_20460467_ChIP-Seq_MEFs_Mouse1.18347099
88NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.18347099
89CLOCK_20551151_ChIP-Seq_293T_Human1.18179381
90HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.17577437
91GATA2_21666600_ChIP-Seq_HMVEC_Human1.16958911
92MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.16893845
93SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.16826061
94SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.16811205
95FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.15695295
96NCOR1_26117541_ChIP-Seq_K562_Human1.15531833
97TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.15524589
98CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15520799
99TET1_21451524_ChIP-Seq_MESCs_Mouse1.14413855
100SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.13995544
101TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12148728
102KDM2B_26808549_Chip-Seq_K562_Human1.11476708
103UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.10585197
104RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08868696
105NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.08386900
106CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08132714
107POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.07872146
108ZFP281_18757296_ChIP-ChIP_E14_Mouse1.06333589
109ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.06188928
110ESR2_21235772_ChIP-Seq_MCF-7_Human1.05758212
111RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.05263141
112SALL4_18804426_ChIP-ChIP_XEN_Mouse1.05247370
113ELF1_17652178_ChIP-ChIP_JURKAT_Human1.05000567
114STAT6_21828071_ChIP-Seq_BEAS2B_Human1.04910334
115CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04569780
116WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04094386
117MYB_21317192_ChIP-Seq_ERMYB_Mouse1.03924174
118CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.02836749
119CHD1_26751641_Chip-Seq_LNCaP_Human1.02327500
120CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.01843622
121IRF1_19129219_ChIP-ChIP_H3396_Human1.00176052
122MYC_19079543_ChIP-ChIP_MESCs_Mouse0.99590794
123EOMES_21245162_ChIP-Seq_HESCs_Human0.99265686
124GATA4_25053715_ChIP-Seq_YYC3_Human0.99143132
125KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99127551
126CREB1_26743006_Chip-Seq_LNCaP_Human0.98488391
127UBF1/2_26484160_Chip-Seq_HMECs_Human0.98425725
128STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97609002
129FOXO3_23340844_ChIP-Seq_DLD1_Human0.97502651
130TFEB_21752829_ChIP-Seq_HELA_Human0.97278330
131RUNX1_22412390_ChIP-Seq_EML_Mouse0.97171001
132CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96535237
133GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96204007
134SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.94542147
135SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.93811562
136FOXA1_25552417_ChIP-Seq_VCAP_Human0.93072950
137EGR1_19032775_ChIP-ChIP_M12_Human0.92238675
138SOX2_20726797_ChIP-Seq_SW620_Human0.90520918
139IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.90351616
140FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.90153447
141NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.88706489
142SRF_21415370_ChIP-Seq_HL-1_Mouse0.87698652
143RUNX_20019798_ChIP-Seq_JUKART_Human0.87585091
144GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.87559068
145GATA2_19941826_ChIP-Seq_K562_Human0.86529350
146SOX17_20123909_ChIP-Seq_XEN_Mouse0.86470832
147AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.85550339
148CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85101587
149EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.84360828
150P63_26484246_Chip-Seq_KERATINOCYTES_Human0.83022300
151GATA1_19941827_ChIP-Seq_MEL_Mouse0.82173602
152CREB1_15753290_ChIP-ChIP_HEK293T_Human0.82079253
153HNF4A_19822575_ChIP-Seq_HepG2_Human0.82002118
154PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79317890
155MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.77212477
156CBP_21632823_ChIP-Seq_H3396_Human0.76251741
157ERG_20887958_ChIP-Seq_HPC-7_Mouse0.74840696
158PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.74366784
159CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.73281929
160PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.73249697
161CTCF_20526341_ChIP-Seq_ESCs_Human0.73203868
162PPAR_26484153_Chip-Seq_NCI-H1993_Human0.73165240
163TRIM28_21343339_ChIP-Seq_HEK293_Human0.72324755
164OCT4_20526341_ChIP-Seq_ESCs_Human0.70586797
165NANOG_20526341_ChIP-Seq_ESCs_Human0.70384106
166BRD4_27068464_Chip-Seq_AML-cells_Mouse0.69020537
167FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.68510587
168CEBPB_22108803_ChIP-Seq_LS180_Human0.68420953
169GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.67910190
170VDR_24763502_ChIP-Seq_THP-1_Human0.67645953
171WT1_19549856_ChIP-ChIP_CCG9911_Human0.67480565
172OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.66369332
173PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.65762177
174STAT1_20625510_ChIP-Seq_HELA_Human0.65632824

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.36004280
2MP0005360_urolithiasis4.90106365
3MP0003806_abnormal_nucleotide_metabolis4.74776879
4MP0000920_abnormal_myelination4.22916055
5MP0009840_abnormal_foam_cell3.91196133
6MP0003705_abnormal_hypodermis_morpholog3.75126543
7MP0005085_abnormal_gallbladder_physiolo3.73527825
8MP0008875_abnormal_xenobiotic_pharmacok3.59381235
9MP0005365_abnormal_bile_salt3.58618881
10MP0003195_calcinosis2.89287759
11MP0003690_abnormal_glial_cell2.73525843
12MP0003950_abnormal_plasma_membrane2.70629694
13MP0002877_abnormal_melanocyte_morpholog2.60054016
14MP0003566_abnormal_cell_adhesion2.52794511
15MP0005083_abnormal_biliary_tract2.38121546
16MP0005058_abnormal_lysosome_morphology2.35885797
17MP0003656_abnormal_erythrocyte_physiolo2.32240673
18MP0005332_abnormal_amino_acid2.31645801
19MP0005451_abnormal_body_composition2.30463624
20MP0003191_abnormal_cellular_cholesterol2.27940562
21MP0003252_abnormal_bile_duct2.14334910
22MP0010234_abnormal_vibrissa_follicle2.13408311
23MP0010329_abnormal_lipoprotein_level2.08988653
24MP0004264_abnormal_extraembryonic_tissu2.08884635
25MP0003329_amyloid_beta_deposits2.06439501
26MP0005076_abnormal_cell_differentiation1.97468078
27MP0004147_increased_porphyrin_level1.97349544
28MP0004272_abnormal_basement_membrane1.96934096
29MP0001666_abnormal_nutrient_absorption1.96144046
30MP0000604_amyloidosis1.90881599
31MP0002118_abnormal_lipid_homeostasis1.87299077
32MP0003186_abnormal_redox_activity1.76514230
33MP0004233_abnormal_muscle_weight1.72792361
34MP0001849_ear_inflammation1.70216567
35MP0005584_abnormal_enzyme/coenzyme_acti1.65258634
36MP0005408_hypopigmentation1.62311266
37MP0006082_CNS_inflammation1.60939054
38MP0002796_impaired_skin_barrier1.60225691
39MP0004185_abnormal_adipocyte_glucose1.57329877
40MP0000609_abnormal_liver_physiology1.47386840
41MP0010352_gastrointestinal_tract_polyps1.46804811
42MP0001661_extended_life_span1.45067658
43MP0003724_increased_susceptibility_to1.38452941
44MP0000858_altered_metastatic_potential1.37965303
45MP0004381_abnormal_hair_follicle1.36515952
46MP0005023_abnormal_wound_healing1.34691412
47MP0008438_abnormal_cutaneous_collagen1.33422650
48MP0004885_abnormal_endolymph1.31347803
49MP0003634_abnormal_glial_cell1.28164439
50MP0005257_abnormal_intraocular_pressure1.26607834
51MP0009643_abnormal_urine_homeostasis1.26093625
52MP0005501_abnormal_skin_physiology1.25387628
53MP0002089_abnormal_postnatal_growth/wei1.25333684
54MP0003300_gastrointestinal_ulcer1.24850915
55MP0010678_abnormal_skin_adnexa1.23097159
56MP0004019_abnormal_vitamin_homeostasis1.21399089
57MP0003011_delayed_dark_adaptation1.21202732
58MP0004782_abnormal_surfactant_physiolog1.17905929
59MP0001915_intracranial_hemorrhage1.16310189
60MP0002138_abnormal_hepatobiliary_system1.15982378
61MP0009780_abnormal_chondrocyte_physiolo1.15205071
62MP0000383_abnormal_hair_follicle1.14591236
63MP0008260_abnormal_autophagy1.14230941
64MP0003091_abnormal_cell_migration1.14144130
65MP0003632_abnormal_nervous_system1.13736700
66MP0003941_abnormal_skin_development1.13592134
67MP0004043_abnormal_pH_regulation1.13517439
68MP0005319_abnormal_enzyme/_coenzyme1.12655739
69MP0001764_abnormal_homeostasis1.12090058
70MP0002060_abnormal_skin_morphology1.11840304
71MP0000465_gastrointestinal_hemorrhage1.07221639
72MP0001730_embryonic_growth_arrest1.06584305
73MP0004858_abnormal_nervous_system1.04088591
74MP0003868_abnormal_feces_composition1.03599716
75MP0001905_abnormal_dopamine_level1.01770565
76MP0008469_abnormal_protein_level1.00964922
77MP0005464_abnormal_platelet_physiology1.00146486
78MP0000537_abnormal_urethra_morphology1.00048823
79MP0005666_abnormal_adipose_tissue0.98827538
80MP0009763_increased_sensitivity_to0.98792706
81MP0000678_abnormal_parathyroid_gland0.96869787
82MP0002419_abnormal_innate_immunity0.95302183
83MP0009672_abnormal_birth_weight0.95115741
84MP0001881_abnormal_mammary_gland0.94183645
85MP0009765_abnormal_xenobiotic_induced0.93124192
86MP0005171_absent_coat_pigmentation0.93018750
87MP0002229_neurodegeneration0.92454383
88MP0000003_abnormal_adipose_tissue0.92274982
89MP0000627_abnormal_mammary_gland0.92211324
90MP0004742_abnormal_vestibular_system0.90505645
91MP0000598_abnormal_liver_morphology0.89811938
92MP0005075_abnormal_melanosome_morpholog0.89575051
93MP0001851_eye_inflammation0.89079840
94MP0009053_abnormal_anal_canal0.88870751
95MP0005636_abnormal_mineral_homeostasis0.88577309
96MP0004142_abnormal_muscle_tone0.88412330
97MP0002086_abnormal_extraembryonic_tissu0.87548228
98MP0002933_joint_inflammation0.86625390
99MP0005375_adipose_tissue_phenotype0.85568995
100MP0002295_abnormal_pulmonary_circulatio0.85348302
101MP0001216_abnormal_epidermal_layer0.84318413
102MP0006036_abnormal_mitochondrial_physio0.83962529
103MP0005025_abnormal_response_to0.83783735
104MP0000747_muscle_weakness0.83547920
105MP0005621_abnormal_cell_physiology0.78986997
106MP0000467_abnormal_esophagus_morphology0.78256849
107MP0002098_abnormal_vibrissa_morphology0.77924153
108MP0009931_abnormal_skin_appearance0.77694720
109MP0009785_altered_susceptibility_to0.77497538
110MP0004947_skin_inflammation0.76874842
111MP0002896_abnormal_bone_mineralization0.76627329
112MP0005410_abnormal_fertilization0.76509760
113MP0003075_altered_response_to0.74331345
114MP0003172_abnormal_lysosome_physiology0.74312208
115MP0009764_decreased_sensitivity_to0.73585099
116MP0004808_abnormal_hematopoietic_stem0.72916296
117MP0000462_abnormal_digestive_system0.72493137
118MP0003436_decreased_susceptibility_to0.71401209
119MP0002080_prenatal_lethality0.68787859
120MP0001529_abnormal_vocalization0.68716107
121MP0003183_abnormal_peptide_metabolism0.68372819
122MP0002998_abnormal_bone_remodeling0.68225715
123MP0008873_increased_physiological_sensi0.68210240
124MP0004957_abnormal_blastocyst_morpholog0.68048906
125MP0000647_abnormal_sebaceous_gland0.67557440
126MP0004134_abnormal_chest_morphology0.67508391
127MP0000377_abnormal_hair_follicle0.67403921
128MP0000639_abnormal_adrenal_gland0.67398174
129MP0005164_abnormal_response_to0.67283306
130MP0009384_cardiac_valve_regurgitation0.66994396
131MP0003984_embryonic_growth_retardation0.66493138
132MP0003631_nervous_system_phenotype0.66440789
133MP0001485_abnormal_pinna_reflex0.65991917
134MP0005409_darkened_coat_color0.64780320
135MP0002396_abnormal_hematopoietic_system0.64535910
136MP0002088_abnormal_embryonic_growth/wei0.62998424
137MP0001790_abnormal_immune_system0.62773740
138MP0005387_immune_system_phenotype0.62773740
139MP0001958_emphysema0.62581673
140MP0005380_embryogenesis_phenotype0.62434516
141MP0001672_abnormal_embryogenesis/_devel0.62434516
142MP0003136_yellow_coat_color0.62227488
143MP0000350_abnormal_cell_proliferation0.62168572
144MP0001243_abnormal_dermal_layer0.61270038
145MP0003115_abnormal_respiratory_system0.60546707
146MP0000685_abnormal_immune_system0.59899595
147MP0009642_abnormal_blood_homeostasis0.58896231
148MP0005376_homeostasis/metabolism_phenot0.58894306
149MP0001533_abnormal_skeleton_physiology0.58551392
150MP0005647_abnormal_sex_gland0.55242355
151MP0005000_abnormal_immune_tolerance0.54710957
152MP0002132_abnormal_respiratory_system0.54038697
153MP0009333_abnormal_splenocyte_physiolog0.53483298
154MP0002723_abnormal_immune_serum0.53233502
155MP0003453_abnormal_keratinocyte_physiol0.52944001
156MP0009697_abnormal_copulation0.51949384
157MP0010368_abnormal_lymphatic_system0.51047899
158MP0002136_abnormal_kidney_physiology0.50895168

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.58881260
2Intrahepatic cholestasis (HP:0001406)5.19167656
3Neurofibrillary tangles (HP:0002185)4.64954187
4Deep venous thrombosis (HP:0002625)4.59387216
5Xanthomatosis (HP:0000991)4.35307524
6Hyperlipoproteinemia (HP:0010980)4.33606464
7Degeneration of the lateral corticospinal tracts (HP:0002314)4.14596453
8Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.14596453
9Prolonged partial thromboplastin time (HP:0003645)3.81636078
10Parakeratosis (HP:0001036)3.72804963
11Abnormality of monocarboxylic acid metabolism (HP:0010996)3.52507133
12Hypobetalipoproteinemia (HP:0003563)3.52303526
13Spastic paraparesis (HP:0002313)3.37369425
14Vertebral compression fractures (HP:0002953)3.29694242
15Abnormality of methionine metabolism (HP:0010901)3.28560038
16Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.21723364
17Cerebral inclusion bodies (HP:0100314)3.12348317
18Asymmetry of the thorax (HP:0001555)3.09562348
19Sensory axonal neuropathy (HP:0003390)3.03169744
20Fat malabsorption (HP:0002630)3.02395953
21Abnormality of aspartate family amino acid metabolism (HP:0010899)3.01558280
22Complement deficiency (HP:0004431)2.97317817
23Protrusio acetabuli (HP:0003179)2.94944718
24Cerebral hypomyelination (HP:0006808)2.94041238
25Hepatosplenomegaly (HP:0001433)2.91623354
26Axonal loss (HP:0003447)2.85687397
27Abnormality of glycolysis (HP:0004366)2.85588303
28Increased serum pyruvate (HP:0003542)2.85588303
29J-shaped sella turcica (HP:0002680)2.84638117
30Steatorrhea (HP:0002570)2.84328083
31Abnormality of serine family amino acid metabolism (HP:0010894)2.82043656
32Abnormality of glycine metabolism (HP:0010895)2.82043656
33Abnormality of fatty-acid metabolism (HP:0004359)2.80067580
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.79770259
35Flat acetabular roof (HP:0003180)2.77364049
36Abnormality of the corticospinal tract (HP:0002492)2.77231621
37Joint hemorrhage (HP:0005261)2.75857463
38Abnormality of the Achilles tendon (HP:0005109)2.75619607
39Hyperammonemia (HP:0001987)2.75390971
40Premature rupture of membranes (HP:0001788)2.71439081
41Onion bulb formation (HP:0003383)2.66678081
42Hemorrhage of the eye (HP:0011885)2.65011153
43Glomerulonephritis (HP:0000099)2.64530029
44Abnormality of sulfur amino acid metabolism (HP:0004339)2.64523685
45Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.64091676
46Peripheral hypomyelination (HP:0007182)2.62224332
47Epidermoid cyst (HP:0200040)2.61704082
48Menorrhagia (HP:0000132)2.59808448
49Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.58605552
50Cerebral hemorrhage (HP:0001342)2.57868885
51Mitral stenosis (HP:0001718)2.53855154
52Vascular calcification (HP:0004934)2.53514921
53Paraparesis (HP:0002385)2.51147563
54Abnormality of the common coagulation pathway (HP:0010990)2.48208564
55Purpura (HP:0000979)2.47006783
56Prolonged neonatal jaundice (HP:0006579)2.44123850
57Vacuolated lymphocytes (HP:0001922)2.40486232
58Stridor (HP:0010307)2.39247619
59Achilles tendon contracture (HP:0001771)2.39113699
60Back pain (HP:0003418)2.37382349
61Amyloidosis (HP:0011034)2.37011332
62Hyperglycinemia (HP:0002154)2.36634355
63Hypolipoproteinemia (HP:0010981)2.34168813
64Congenital ichthyosiform erythroderma (HP:0007431)2.32764651
65Ketosis (HP:0001946)2.32056016
66Opisthotonus (HP:0002179)2.30571330
67Abnormal auditory evoked potentials (HP:0006958)2.29690473
68Cervical subluxation (HP:0003308)2.29454494
69Hyperacusis (HP:0010780)2.28953600
70Slow saccadic eye movements (HP:0000514)2.28728809
71Gingival bleeding (HP:0000225)2.27594517
72Segmental peripheral demyelination/remyelination (HP:0003481)2.26388467
73Conjugated hyperbilirubinemia (HP:0002908)2.26051127
74Myocardial infarction (HP:0001658)2.25173736
75Cardiovascular calcification (HP:0011915)2.22227205
76Dicarboxylic aciduria (HP:0003215)2.20857643
77Abnormality of dicarboxylic acid metabolism (HP:0010995)2.20857643
78Hyperbilirubinemia (HP:0002904)2.20418500
79Autoamputation (HP:0001218)2.19152856
80Abnormal gallbladder physiology (HP:0012438)2.17333285
81Cholecystitis (HP:0001082)2.17333285
82Increased serum ferritin (HP:0003281)2.17234862
83Acanthocytosis (HP:0001927)2.16769965
84Osteolytic defects of the phalanges of the hand (HP:0009771)2.15886587
85Osteolytic defects of the hand bones (HP:0009699)2.15886587
86Abnormality of the intrinsic pathway (HP:0010989)2.15022691
87Methylmalonic acidemia (HP:0002912)2.14778781
88Urinary glycosaminoglycan excretion (HP:0003541)2.12937101
89Mucopolysacchariduria (HP:0008155)2.12937101
90Premature skin wrinkling (HP:0100678)2.12934443
91Dysostosis multiplex (HP:0000943)2.12322211
92Peripheral demyelination (HP:0011096)2.12140994
93Loss of speech (HP:0002371)2.10590659
94Reticulocytosis (HP:0001923)2.10390603
95Increased mean platelet volume (HP:0011877)2.10254940
96Distal lower limb muscle weakness (HP:0009053)2.09669019
97Leukodystrophy (HP:0002415)2.09096670
983-Methylglutaconic aciduria (HP:0003535)2.09015056
99Intention tremor (HP:0002080)2.07506293
100Ileus (HP:0002595)2.06674981
101Abnormality of iron homeostasis (HP:0011031)2.06277307
102Hypophosphatemic rickets (HP:0004912)2.06204899
103Abnormality of carpal bone ossification (HP:0006257)2.06031190
104Abnormal gallbladder morphology (HP:0012437)2.05781929
105Thin bony cortex (HP:0002753)2.05617534
106Increased neuronal autofluorescent lipopigment (HP:0002074)2.03900900
107Hypercholesterolemia (HP:0003124)2.03480790
108Cerebral aneurysm (HP:0004944)2.02303968
109Abnormality of glutamine family amino acid metabolism (HP:0010902)1.99804762
110Delayed CNS myelination (HP:0002188)1.99167945
111Ulnar bowing (HP:0003031)1.99041151
112Abnormality of pyrimidine metabolism (HP:0004353)1.98553903
113Abnormality of complement system (HP:0005339)1.98431142
114Brushfield spots (HP:0001088)1.97750372
115Systemic lupus erythematosus (HP:0002725)1.97312286
116Renal Fanconi syndrome (HP:0001994)1.97210847
117Spastic tetraparesis (HP:0001285)1.96501390
118Hyperglycinuria (HP:0003108)1.95957138
119Abnormal platelet volume (HP:0011876)1.95115435
120Bone pain (HP:0002653)1.93280927
121Abnormality of macrophages (HP:0004311)1.92820751
122Spastic gait (HP:0002064)1.92215812
123Abnormality of serum amino acid levels (HP:0003112)1.90346920
124Abnormality of glycosaminoglycan metabolism (HP:0004371)1.89657562
125Abnormality of mucopolysaccharide metabolism (HP:0011020)1.89657562
126Abnormality of polysaccharide metabolism (HP:0011012)1.89657562
127Short nail (HP:0001799)1.89633312
128Abnormality of transition element cation homeostasis (HP:0011030)1.88933213
129CNS hypomyelination (HP:0003429)1.88453494
130Hypoglycemic coma (HP:0001325)1.88147336
131Abnormal ossification of hand bones (HP:0005921)1.87780083
132Abdominal distention (HP:0003270)1.87288425
133Broad face (HP:0000283)1.85786301
134Abnormality of the distal phalanges of the toes (HP:0010182)1.84499682
135Impaired platelet aggregation (HP:0003540)1.84346466
136Abnormal platelet function (HP:0011869)1.84346466
137Hypokalemic alkalosis (HP:0001949)1.83285917
138Supranuclear gaze palsy (HP:0000605)1.83275820
139Nephritis (HP:0000123)1.82259362
140Blue sclerae (HP:0000592)1.81939264
141Elevated alkaline phosphatase (HP:0003155)1.81534087
142Lethargy (HP:0001254)1.81046160
143Abnormality of the heme biosynthetic pathway (HP:0010472)1.80785968
144Distal lower limb amyotrophy (HP:0008944)1.80453580
145Erythroderma (HP:0001019)1.79951587
146Arterial tortuosity (HP:0005116)1.79518680
147Abnormality of the thoracic spine (HP:0100711)1.77453539
148Hyperparathyroidism (HP:0000843)1.76911771
149Upper limb amyotrophy (HP:0009129)1.75512216
150Distal upper limb amyotrophy (HP:0007149)1.75512216
151Ankyloglossia (HP:0010296)1.74956692
152Termporal pattern (HP:0011008)1.73212961
153Insidious onset (HP:0003587)1.73212961
154Esophageal varix (HP:0002040)1.72537684
155Abnormal delivery (HP:0001787)1.71334890
156Cholelithiasis (HP:0001081)1.71197574
157Abnormality of the acetabulum (HP:0003170)1.71078387
158Hepatocellular carcinoma (HP:0001402)1.70749414
159Abnormal tarsal ossification (HP:0008369)1.69080614
160Polycythemia (HP:0001901)1.68762929
161Rickets (HP:0002748)1.66750450
162Abnormal enzyme/coenzyme activity (HP:0012379)1.66224617
163Spinal cord compression (HP:0002176)1.66096183
164Disproportionate tall stature (HP:0001519)1.66069629
165Abnormality of alkaline phosphatase activity (HP:0004379)1.65208344
166Micronodular cirrhosis (HP:0001413)1.65143791
167Deformed sella turcica (HP:0002681)1.64726704
168Abnormal foot bone ossification (HP:0010675)1.64123827
169Hypophosphatemia (HP:0002148)1.62536972
170Aneurysm (HP:0002617)1.61416044
171Interstitial pulmonary disease (HP:0006530)1.61384867
172Abnormality of oral frenula (HP:0000190)1.61238637
173Pathologic fracture (HP:0002756)1.61095883

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.81770262
2TRIB35.16356931
3EPHB14.62160474
4OXSR14.31222425
5IRAK32.98357986
6SMG12.95179595
7PBK2.89274045
8MET2.86087771
9EPHA22.80764186
10TESK22.74008412
11SCYL22.69295654
12PKN22.44174795
13BCKDK2.42372660
14EEF2K2.33597625
15MAPKAPK52.32691162
16FGFR22.31188041
17WNK42.25362593
18CDK192.14142794
19CSNK1G32.11572507
20PKN12.06142262
21CSNK1A1L2.04792119
22RIPK12.02773812
23CDK121.98989352
24PAK41.92214448
25BCR1.88608984
26LIMK11.87490988
27PRPF4B1.80648985
28PDGFRA1.79055395
29CSNK1G11.70959755
30MST41.58765346
31EIF2AK11.58405228
32TESK11.57024878
33RPS6KB21.47340111
34TNIK1.40786961
35PTK21.34183824
36CSNK1G21.31856208
37KSR21.29759728
38CLK11.27946368
39BLK1.25224104
40MAP3K31.24245644
41LATS21.21044509
42PTK61.20322478
43FGFR41.20041651
44TAOK21.19342219
45STK161.18573748
46NEK61.16049375
47WNK11.13268715
48SIK11.12620329
49MTOR1.12285482
50TTN1.11683003
51MAP4K11.09149088
52ERN11.07175677
53ROCK21.06079495
54ERBB41.04354399
55CSF1R1.03991770
56KDR1.02916393
57CAMK2B1.02188327
58TRPM71.01085710
59MAPKAPK30.99998740
60ARAF0.99824300
61ICK0.99641989
62KIT0.99561670
63TAOK30.98413009
64PRKCQ0.97174114
65LMTK20.95531763
66ILK0.94288513
67MAP3K100.92521713
68MAP3K10.92300619
69CDK70.92071583
70MAPK150.90440281
71RET0.90108828
72MAP3K20.89653580
73ITK0.89379124
74CAMK2D0.87499625
75CAMK2G0.86818733
76TIE10.83066485
77NTRK10.80355305
78STK100.78570743
79TBK10.78448322
80FGR0.77651215
81LRRK20.76696416
82MAP3K80.76288699
83GSK3A0.75790268
84CSK0.75696014
85IRAK40.74294295
86CDK60.74260720
87PDPK10.73491174
88SIK30.72631404
89NME20.70695301
90BTK0.69699113
91ABL20.69421992
92UHMK10.67324338
93TYK20.66091904
94FGFR30.64896647
95PRKD10.63951761
96PRKG20.59111936
97RPS6KA50.58717363
98PIK3CG0.57428921
99DYRK20.57120872
100SGK4940.56972104
101SGK2230.56972104
102MAP2K20.56242097
103LCK0.54266906
104MELK0.53544745
105MST1R0.52418018
106PRKD20.51964352
107GRK60.51963863
108CDC42BPA0.51536904
109RPS6KA20.50854104
110STK380.50493189
111MYLK0.50268125
112IKBKE0.48688669
113BUB10.47546993
114CDK40.47222194
115PDGFRB0.47104862
116LATS10.47045512
117MUSK0.46772950
118IRAK10.45471628
119MAP3K130.45334677
120MAP3K140.43178673
121MAPKAPK20.43005029
122MAP2K10.42619991
123BRAF0.42371177
124NEK90.42221449
125MAP3K90.41777074
126IRAK20.41569569
127PAK10.41081672
128ALK0.40145413
129TTK0.39487317
130EIF2AK30.38876551
131MAP2K30.38867867
132TAOK10.38579709
133HIPK20.38216914
134ABL10.37720061
135ZAP700.37532249
136IKBKB0.37416918
137FYN0.37322158
138CDK80.37003720
139LYN0.36807989
140MAP3K120.36318666
141JAK20.35874591
142AKT20.35631770
143MAPK40.35198392
144DMPK0.35035564
145CDK90.34897321
146BRSK10.34550970
147PRKD30.34485957
148RAF10.33938971
149MAP3K110.33381714
150PAK30.32746681
151MAP3K60.32052488
152MARK20.31991584
153TGFBR20.31854200
154PDK10.31707538
155STK40.31309191
156YES10.31103662
157RPS6KL10.31009763
158RPS6KC10.31009763
159PIK3CA0.30561959
160PRKACB0.30305824
161BMX0.29901989
162BMPR1B0.29871906
163DDR20.29539030
164PAK20.29316201
165CSNK1D0.29083625
166MAPK110.28429846
167PIM20.27851114
168CSNK1A10.27151015
169MAPK70.26477860

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001003.73727028
2Fatty acid elongation_Homo sapiens_hsa000623.72411565
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.38308618
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.20192189
5Primary bile acid biosynthesis_Homo sapiens_hsa001203.12235808
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.86997638
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.85824664
8Nitrogen metabolism_Homo sapiens_hsa009102.59675241
9Histidine metabolism_Homo sapiens_hsa003402.45325747
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.33903586
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.17747318
12Vitamin B6 metabolism_Homo sapiens_hsa007502.13108024
13Butanoate metabolism_Homo sapiens_hsa006502.06823861
14Sulfur metabolism_Homo sapiens_hsa009202.01659056
15Peroxisome_Homo sapiens_hsa041462.00201273
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.99929310
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.98135616
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.94591646
19Complement and coagulation cascades_Homo sapiens_hsa046101.92382313
20Fatty acid metabolism_Homo sapiens_hsa012121.85445412
21Fatty acid degradation_Homo sapiens_hsa000711.85242060
22Folate biosynthesis_Homo sapiens_hsa007901.83551170
23Propanoate metabolism_Homo sapiens_hsa006401.83371871
24Tryptophan metabolism_Homo sapiens_hsa003801.74951665
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.72411923
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.71160860
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.68127703
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.65955218
29Chemical carcinogenesis_Homo sapiens_hsa052041.61717595
30Pentose and glucuronate interconversions_Homo sapiens_hsa000401.59697529
31Thyroid cancer_Homo sapiens_hsa052161.57765584
32Fructose and mannose metabolism_Homo sapiens_hsa000511.56221675
33Arginine biosynthesis_Homo sapiens_hsa002201.53320376
34Retinol metabolism_Homo sapiens_hsa008301.48704903
35Galactose metabolism_Homo sapiens_hsa000521.47115303
36Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.44789381
37beta-Alanine metabolism_Homo sapiens_hsa004101.44482682
38Central carbon metabolism in cancer_Homo sapiens_hsa052301.44116013
39Staphylococcus aureus infection_Homo sapiens_hsa051501.43228814
40Chronic myeloid leukemia_Homo sapiens_hsa052201.41789327
41Ether lipid metabolism_Homo sapiens_hsa005651.40682530
42Protein export_Homo sapiens_hsa030601.39697822
43Arginine and proline metabolism_Homo sapiens_hsa003301.39446241
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.37387385
45PPAR signaling pathway_Homo sapiens_hsa033201.32586698
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.31039332
47Glutathione metabolism_Homo sapiens_hsa004801.28636971
48Caffeine metabolism_Homo sapiens_hsa002321.28004843
49Bladder cancer_Homo sapiens_hsa052191.25460884
50Acute myeloid leukemia_Homo sapiens_hsa052211.24176593
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.24111592
52Vitamin digestion and absorption_Homo sapiens_hsa049771.23854369
53Non-small cell lung cancer_Homo sapiens_hsa052231.19323865
54Drug metabolism - other enzymes_Homo sapiens_hsa009831.11115023
55Tyrosine metabolism_Homo sapiens_hsa003501.08072702
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.07729350
57Pyruvate metabolism_Homo sapiens_hsa006201.07084489
58Endometrial cancer_Homo sapiens_hsa052131.04526441
59N-Glycan biosynthesis_Homo sapiens_hsa005101.04522360
60ABC transporters_Homo sapiens_hsa020101.04023981
61Pancreatic cancer_Homo sapiens_hsa052121.03011233
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.02377745
63Cysteine and methionine metabolism_Homo sapiens_hsa002701.01911306
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98976202
65Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.97631278
66Linoleic acid metabolism_Homo sapiens_hsa005910.97487273
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94143861
68Selenocompound metabolism_Homo sapiens_hsa004500.88594712
69Sulfur relay system_Homo sapiens_hsa041220.86577839
70Fat digestion and absorption_Homo sapiens_hsa049750.82013938
71Insulin signaling pathway_Homo sapiens_hsa049100.81273535
72Insulin resistance_Homo sapiens_hsa049310.78803598
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78716294
74Bile secretion_Homo sapiens_hsa049760.78575699
75Lysosome_Homo sapiens_hsa041420.78181716
76Phenylalanine metabolism_Homo sapiens_hsa003600.77002958
77VEGF signaling pathway_Homo sapiens_hsa043700.74603606
78Small cell lung cancer_Homo sapiens_hsa052220.74034158
79Pentose phosphate pathway_Homo sapiens_hsa000300.73632563
80Biosynthesis of amino acids_Homo sapiens_hsa012300.73067519
81Proteoglycans in cancer_Homo sapiens_hsa052050.71657491
82Focal adhesion_Homo sapiens_hsa045100.69877030
83AMPK signaling pathway_Homo sapiens_hsa041520.68899468
84Carbon metabolism_Homo sapiens_hsa012000.68556323
85Prostate cancer_Homo sapiens_hsa052150.67832090
86Amoebiasis_Homo sapiens_hsa051460.67395613
87* Metabolic pathways_Homo sapiens_hsa011000.67384640
88Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67306780
89mTOR signaling pathway_Homo sapiens_hsa041500.65949828
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65703539
91Starch and sucrose metabolism_Homo sapiens_hsa005000.65354992
92Vibrio cholerae infection_Homo sapiens_hsa051100.61098562
93Glycerolipid metabolism_Homo sapiens_hsa005610.60534168
94Adherens junction_Homo sapiens_hsa045200.60046342
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.57379596
96Glioma_Homo sapiens_hsa052140.57169874
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56557749
98ErbB signaling pathway_Homo sapiens_hsa040120.55266569
992-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.53967117
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52245305
101Notch signaling pathway_Homo sapiens_hsa043300.51827078
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50605575
103Fatty acid biosynthesis_Homo sapiens_hsa000610.48970214
104Arachidonic acid metabolism_Homo sapiens_hsa005900.48650190
105Malaria_Homo sapiens_hsa051440.46691934
106Cyanoamino acid metabolism_Homo sapiens_hsa004600.46096408
107* Sphingolipid metabolism_Homo sapiens_hsa006000.45966461
108Apoptosis_Homo sapiens_hsa042100.44127439
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.42948515
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41625483
111Inositol phosphate metabolism_Homo sapiens_hsa005620.40824677
112Choline metabolism in cancer_Homo sapiens_hsa052310.39604168
113HIF-1 signaling pathway_Homo sapiens_hsa040660.38994230
114Maturity onset diabetes of the young_Homo sapiens_hsa049500.38681913
115Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38061342
116Prolactin signaling pathway_Homo sapiens_hsa049170.37614826
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37320222
118Other glycan degradation_Homo sapiens_hsa005110.33965631
119Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.28376773
120Oxidative phosphorylation_Homo sapiens_hsa001900.28244905
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26359637
122Lysine degradation_Homo sapiens_hsa003100.23225799
123Regulation of autophagy_Homo sapiens_hsa041400.19238552
124Prion diseases_Homo sapiens_hsa050200.17580445
125Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.15582831
126Phagosome_Homo sapiens_hsa041450.15403310
127Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.11989562
128Glycosaminoglycan degradation_Homo sapiens_hsa005310.11166357
129Mineral absorption_Homo sapiens_hsa049780.10832746
130Autoimmune thyroid disease_Homo sapiens_hsa053200.10358722
131Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.09090140
132Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.08923518
133Parkinsons disease_Homo sapiens_hsa050120.07611352
134Ovarian steroidogenesis_Homo sapiens_hsa049130.07546945
135Renin-angiotensin system_Homo sapiens_hsa046140.07542009
136Proteasome_Homo sapiens_hsa030500.07304332
137Pertussis_Homo sapiens_hsa051330.07273114
138Renal cell carcinoma_Homo sapiens_hsa052110.06553217
139ECM-receptor interaction_Homo sapiens_hsa045120.05266936
140One carbon pool by folate_Homo sapiens_hsa006700.04782098
141Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.04595584
142Hepatitis C_Homo sapiens_hsa051600.02441707
143Alzheimers disease_Homo sapiens_hsa050100.01532297
144Leukocyte transendothelial migration_Homo sapiens_hsa046700.01348386

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