CERS3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the ceramide synthase family of genes. The ceramide synthase enzymes regulate sphingolipid synthesis by catalyzing the formation of ceramides from sphingoid base and acyl-coA substrates. This family member is involved in the synthesis of ceramides with ultra-long-chain acyl moieties (ULC-Cers), important to the epidermis in its role in creating a protective barrier from the environment. The protein encoded by this gene has also been implicated in modification of the lipid structures required for spermatogenesis. Mutations in this gene have been associated with male fertility defects, and epidermal defects, including ichthyosis. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptonemal complex organization (GO:0070193)9.64409203
2fusion of sperm to egg plasma membrane (GO:0007342)9.15123831
3synaptonemal complex assembly (GO:0007130)8.84559337
4DNA methylation involved in gamete generation (GO:0043046)8.80140003
5axonemal dynein complex assembly (GO:0070286)8.46111121
6desmosome organization (GO:0002934)8.08582878
7sperm motility (GO:0030317)7.87303255
8acrosome assembly (GO:0001675)7.46914052
9male meiosis I (GO:0007141)7.23102429
10acrosome reaction (GO:0007340)7.16584608
11multicellular organism reproduction (GO:0032504)7.15947740
12sperm-egg recognition (GO:0035036)7.08647083
13establishment of skin barrier (GO:0061436)7.04295692
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.95927417
15spermatid development (GO:0007286)6.88215867
16motile cilium assembly (GO:0044458)6.86426186
17plasma membrane fusion (GO:0045026)6.85755299
18keratinization (GO:0031424)6.78498679
19epithelial cilium movement (GO:0003351)6.74180276
20binding of sperm to zona pellucida (GO:0007339)6.62548540
21regulation of water loss via skin (GO:0033561)6.36587885
22cell-cell recognition (GO:0009988)6.22273203
23cilium movement (GO:0003341)6.19784947
24chromosome organization involved in meiosis (GO:0070192)6.17290867
25meiotic nuclear division (GO:0007126)5.89031125
26linoleic acid metabolic process (GO:0043651)5.86546286
27meiosis I (GO:0007127)5.82590824
28intermediate filament cytoskeleton organization (GO:0045104)5.81771045
29reproduction (GO:0000003)5.67962121
30regulation of meiosis I (GO:0060631)5.63739024
31intermediate filament-based process (GO:0045103)5.63176515
32phosphatidylinositol acyl-chain remodeling (GO:0036149)5.61860193
33negative regulation of inclusion body assembly (GO:0090084)5.60464119
34lipoxygenase pathway (GO:0019372)5.57587888
35cell wall macromolecule catabolic process (GO:0016998)5.56649599
36cell wall macromolecule metabolic process (GO:0044036)5.56649599
37phosphatidylserine acyl-chain remodeling (GO:0036150)5.55485427
38establishment of planar polarity (GO:0001736)5.31983032
39establishment of tissue polarity (GO:0007164)5.31983032
40skin morphogenesis (GO:0043589)5.10627424
41detection of bacterium (GO:0016045)5.06731870
42hemidesmosome assembly (GO:0031581)4.96610871
43interferon-gamma secretion (GO:0072643)4.85417619
44meiotic cell cycle (GO:0051321)4.82938625
45single fertilization (GO:0007338)4.82220053
46polarized epithelial cell differentiation (GO:0030859)4.76468698
47negative regulation of keratinocyte proliferation (GO:0010839)4.76364202
48fertilization (GO:0009566)4.75600812
49regulation of cilium movement (GO:0003352)4.73548452
50lateral sprouting from an epithelium (GO:0060601)4.72664741
51molting cycle (GO:0042303)4.62334225
52hair cycle (GO:0042633)4.62334225
53detection of other organism (GO:0098543)4.60085438
54phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.52149479
55genitalia morphogenesis (GO:0035112)4.47711120
56germ cell development (GO:0007281)4.42646348
57surfactant homeostasis (GO:0043129)4.38627925
58fatty acid elongation (GO:0030497)4.33041199
59epithelial cell differentiation involved in prostate gland development (GO:0060742)4.30869654
60hair follicle morphogenesis (GO:0031069)4.29823764
61* keratinocyte differentiation (GO:0030216)4.28858629
62cellular process involved in reproduction in multicellular organism (GO:0022412)4.28182559
63multicellular organismal water homeostasis (GO:0050891)4.27729418
64phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.27413814
65spermatogenesis (GO:0007283)4.26791297
66male gamete generation (GO:0048232)4.24917611
67gene silencing by RNA (GO:0031047)4.22007729
68regulation of inclusion body assembly (GO:0090083)4.21804783
69ventricular system development (GO:0021591)4.19278847
70regulation of glomerular filtration (GO:0003093)4.14483047
71phosphatidylcholine acyl-chain remodeling (GO:0036151)4.14129312
72sperm capacitation (GO:0048240)4.12239790
73protein localization to cilium (GO:0061512)4.10282025
74regulation of keratinocyte proliferation (GO:0010837)4.10105235
75negative regulation of interferon-gamma production (GO:0032689)4.07331645
76gamete generation (GO:0007276)3.95326419
77regulation of natural killer cell differentiation (GO:0032823)3.94168740
78chemical homeostasis within a tissue (GO:0048875)3.92418241
79epithelium development (GO:0060429)3.90535523
80organic cation transport (GO:0015695)3.85537640
81regulation of keratinocyte differentiation (GO:0045616)3.77392742
82peptide cross-linking (GO:0018149)3.72202055
83gap junction assembly (GO:0016264)3.71161188
84purine ribonucleotide transport (GO:0015868)3.67946267
85regulation of ruffle assembly (GO:1900027)3.67407122
86negative regulation of heart growth (GO:0061117)3.66751351
87negative regulation of cardiac muscle tissue growth (GO:0055022)3.66751351
88keratinocyte proliferation (GO:0043616)3.63157581
89positive regulation of epidermis development (GO:0045684)3.59307654
90synapsis (GO:0007129)3.58713314
91positive regulation of epidermal cell differentiation (GO:0045606)3.56304933
92adenine nucleotide transport (GO:0051503)3.53618176
93phosphatidylserine metabolic process (GO:0006658)3.53537045
94meiotic cell cycle process (GO:1903046)3.48764144
95carnitine metabolic process (GO:0009437)3.45155442
96water homeostasis (GO:0030104)3.42379969
97renal system process involved in regulation of blood volume (GO:0001977)3.38159253
98* epidermal cell differentiation (GO:0009913)3.37156890
99cell-substrate junction assembly (GO:0007044)3.34465634
100positive regulation of monocyte chemotaxis (GO:0090026)3.31999829
101intermediate filament organization (GO:0045109)3.26751826
102regulation of epidermis development (GO:0045682)3.21720477
103seminiferous tubule development (GO:0072520)3.21010311
104ventricular cardiac muscle cell action potential (GO:0086005)3.20413873
105hair cycle process (GO:0022405)3.16697233
106molting cycle process (GO:0022404)3.16697233
107intraciliary transport (GO:0042073)3.15699057
108bundle of His cell to Purkinje myocyte communication (GO:0086069)3.14298644
109multicellular organismal reproductive process (GO:0048609)3.12308313
110regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.11425576
111epidermis development (GO:0008544)3.06261381
112DNA methylation (GO:0006306)3.06050816
113DNA alkylation (GO:0006305)3.06050816
114endothelium development (GO:0003158)3.05997089
115intestinal epithelial cell development (GO:0060576)3.05574294
116purine nucleotide transport (GO:0015865)3.01329923
117sex differentiation (GO:0007548)3.00986733
118regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.00374578
119positive regulation of meiotic cell cycle (GO:0051446)2.96067314
120positive regulation of keratinocyte differentiation (GO:0045618)2.93431787
121regulation of protein polyubiquitination (GO:1902914)2.92372772
122regulation of epidermal cell differentiation (GO:0045604)2.92149448
123cell recognition (GO:0008037)2.91614355
124cellular response to gamma radiation (GO:0071480)2.90979006
125phospholipid catabolic process (GO:0009395)2.89064479
126sequestering of metal ion (GO:0051238)2.88857315
127alditol phosphate metabolic process (GO:0052646)2.87569950
128left/right pattern formation (GO:0060972)2.87011339
129negative regulation of interleukin-17 production (GO:0032700)2.86938490
130planar cell polarity pathway involved in neural tube closure (GO:0090179)2.85711908
131eyelid development in camera-type eye (GO:0061029)2.85413391
132regulation of heart rate by cardiac conduction (GO:0086091)2.84425626
133atrial cardiac muscle cell action potential (GO:0086014)2.84016213
134keratinocyte development (GO:0003334)2.83856280
135skin development (GO:0043588)2.80627157
136ectoderm development (GO:0007398)2.79631336
137calcium ion-dependent exocytosis (GO:0017156)2.79524919
138carnitine transmembrane transport (GO:1902603)2.77718378
139regulation of T cell chemotaxis (GO:0010819)2.76667714
140positive regulation of T cell chemotaxis (GO:0010820)2.76667714
141regulation of response to osmotic stress (GO:0047484)2.75594923
142microtubule severing (GO:0051013)2.75030852
143G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.74934225
144long-chain fatty acid biosynthetic process (GO:0042759)2.74639518
145multicellular organismal development (GO:0007275)2.74120348
146renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.73641156
147negative regulation of epidermis development (GO:0045683)2.72448224
148regulation of axon regeneration (GO:0048679)2.70447420
149regulation of neuron projection regeneration (GO:0070570)2.70447420
150defense response to fungus (GO:0050832)2.62545961
151cell communication involved in cardiac conduction (GO:0086065)2.55255232
152cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.53575387
153detection of external biotic stimulus (GO:0098581)2.51139807
154atrioventricular valve morphogenesis (GO:0003181)2.49600235
155regulation of transforming growth factor beta1 production (GO:0032908)2.49127463
156regulation of hair cycle (GO:0042634)2.48689821
157epithelial cell proliferation (GO:0050673)2.45082609
158one-carbon compound transport (GO:0019755)2.44173619
159* epithelial cell differentiation (GO:0030855)2.41710588
160negative regulation of epidermal cell differentiation (GO:0045605)2.39889858
161regulation of monocyte chemotaxis (GO:0090025)2.38524744
162hair cell differentiation (GO:0035315)2.37058095
163retinol metabolic process (GO:0042572)2.33617126
164cardiac muscle cell action potential involved in contraction (GO:0086002)2.33207460
165mitotic G1 DNA damage checkpoint (GO:0031571)2.32769910
166phospholipid efflux (GO:0033700)2.32364269
167regulation of hair follicle development (GO:0051797)2.30907434
168positive regulation of cholesterol efflux (GO:0010875)2.30227898
169prostate gland epithelium morphogenesis (GO:0060740)2.27642161
170regulation of protein localization to cell surface (GO:2000008)2.26992168
171cardiac muscle cell action potential (GO:0086001)2.26356572
172cardiac conduction (GO:0061337)2.26322747
173polyol transport (GO:0015791)2.24792629
174cell-cell junction assembly (GO:0007043)2.23405693
175epithelial cell-cell adhesion (GO:0090136)2.21362325
176cilium or flagellum-dependent cell motility (GO:0001539)13.5630037
177piRNA metabolic process (GO:0034587)13.0317556
178male meiosis (GO:0007140)10.3829994

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.63575029
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.27422778
3EZH2_22144423_ChIP-Seq_EOC_Human4.92233132
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.27084354
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.77283395
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.76168320
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.49651462
8VDR_22108803_ChIP-Seq_LS180_Human2.32962503
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.78657628
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.76622201
11BCAT_22108803_ChIP-Seq_LS180_Human1.73400006
12ESR2_21235772_ChIP-Seq_MCF-7_Human1.72667124
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.72255904
14PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.70172269
15HIF1A_21447827_ChIP-Seq_MCF-7_Human1.69976498
16RXR_22108803_ChIP-Seq_LS180_Human1.69284676
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62470547
18PCGF2_27294783_Chip-Seq_NPCs_Mouse1.60240406
19TCF4_18268006_ChIP-ChIP_LS174T_Human1.58219513
20ESR1_21235772_ChIP-Seq_MCF-7_Human1.56657541
21TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.51750529
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.51545899
23ELK4_26923725_Chip-Seq_MESODERM_Mouse1.50768004
24SOX9_24532713_ChIP-Seq_HFSC_Mouse1.50635234
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49396949
26EGR1_19032775_ChIP-ChIP_M12_Human1.40362720
27RNF2_27304074_Chip-Seq_NSC_Mouse1.39802549
28ZNF274_21170338_ChIP-Seq_K562_Hela1.38126046
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.37908000
30P63_26484246_Chip-Seq_KERATINOCYTES_Human1.35556656
31KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.34104529
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.31871682
33GATA1_26923725_Chip-Seq_HPCs_Mouse1.31645979
34NFE2_27457419_Chip-Seq_LIVER_Mouse1.29180130
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26848031
36ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.24323717
37ZNF263_19887448_ChIP-Seq_K562_Human1.22151458
38UBF1/2_26484160_Chip-Seq_HMECs_Human1.21691796
39SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21389063
40ESR1_20079471_ChIP-ChIP_T-47D_Human1.20909472
41TAL1_26923725_Chip-Seq_HPCs_Mouse1.19521728
42RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.18706875
43SOX2_20726797_ChIP-Seq_SW620_Human1.17392684
44KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16364521
45TP63_23658742_ChIP-Seq_EP156T_Human1.15905650
46TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15668570
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.15341652
48KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13870467
49FOXO3_23340844_ChIP-Seq_DLD1_Human1.12935548
50ATF3_27146783_Chip-Seq_COLON_Human1.12708222
51TP53_18474530_ChIP-ChIP_U2OS_Human1.12340566
52GATA3_24758297_ChIP-Seq_MCF-7_Human1.08606288
53EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08425205
54SUZ12_27294783_Chip-Seq_ESCs_Mouse1.08043495
55FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.07526229
56PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.07381105
57WDR5_24793694_ChIP-Seq_LNCAP_Human1.06980382
58SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.06639241
59SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.06639241
60KDM2B_26808549_Chip-Seq_REH_Human1.05320701
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04156959
62CBP_20019798_ChIP-Seq_JUKART_Human1.04156959
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.03602279
64SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.03056217
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02112925
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02112925
67RUNX1_27514584_Chip-Seq_MCF-7_Human1.01986673
68CTBP2_25329375_ChIP-Seq_LNCAP_Human1.01906528
69OCT4_18555785_Chip-Seq_ESCs_Mouse1.01813994
70TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01303871
71CRX_20693478_ChIP-Seq_RETINA_Mouse1.01234666
72CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00456918
73AR_21572438_ChIP-Seq_LNCaP_Human0.99809630
74EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99477727
75STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.99474272
76NANOG_18555785_Chip-Seq_ESCs_Mouse0.99391522
77RARG_19884340_ChIP-ChIP_MEFs_Mouse0.98934108
78CTCF_27219007_Chip-Seq_Bcells_Human0.97880562
79CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97810590
80GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.97486937
81PPAR_26484153_Chip-Seq_NCI-H1993_Human0.97266634
82ERG_20517297_ChIP-Seq_VCAP_Human0.97110517
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96805617
84RNF2_27304074_Chip-Seq_ESCs_Mouse0.96686416
85ZFP57_27257070_Chip-Seq_ESCs_Mouse0.96607225
86BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96193826
87GATA6_21074721_ChIP-Seq_CACO-2_Human0.96049549
88ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95914967
89KLF4_18555785_Chip-Seq_ESCs_Mouse0.95815843
90TBL1_22424771_ChIP-Seq_293T_Human0.95319904
91TP63_22573176_ChIP-Seq_HFKS_Human0.95301483
92ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95282768
93ARNT_22903824_ChIP-Seq_MCF-7_Human0.95090791
94FOXA1_27270436_Chip-Seq_PROSTATE_Human0.94319554
95FOXA1_25329375_ChIP-Seq_VCAP_Human0.94319554
96VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.93985189
97AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93824913
98P300_18555785_Chip-Seq_ESCs_Mouse0.93660938
99BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.92830783
100TCF4_22108803_ChIP-Seq_LS180_Human0.92524057
101CDX2_22108803_ChIP-Seq_LS180_Human0.91858986
102CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.91771122
103SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91759496
104GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.91239242
105STAT3_18555785_Chip-Seq_ESCs_Mouse0.91098949
106EZH2_27294783_Chip-Seq_ESCs_Mouse0.91095586
107ZNF217_24962896_ChIP-Seq_MCF-7_Human0.91066437
108SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.89861478
109P53_22387025_ChIP-Seq_ESCs_Mouse0.89776399
110SMAD3_21741376_ChIP-Seq_EPCs_Human0.89525240
111CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.89211534
112UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.88795848
113TCF4_23295773_ChIP-Seq_U87_Human0.88451252
114MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88136967
115PHF8_20622853_ChIP-Seq_HELA_Human0.88125072
116AHR_22903824_ChIP-Seq_MCF-7_Human0.87351593
117JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86438296
118GATA3_21867929_ChIP-Seq_TH1_Mouse0.86156264
119EZH2_27304074_Chip-Seq_ESCs_Mouse0.85941901
120ETV1_20927104_ChIP-Seq_GIST48_Human0.85776728
121OCT4_21477851_ChIP-Seq_ESCs_Mouse0.85525813
122CTBP1_25329375_ChIP-Seq_LNCAP_Human0.85305730
123AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.85183086
124RACK7_27058665_Chip-Seq_MCF-7_Human0.84470240
125STAT1_17558387_ChIP-Seq_HELA_Human0.84374900
126CJUN_26792858_Chip-Seq_BT549_Human0.84081084
127FOXM1_26456572_ChIP-Seq_MCF-7_Human0.83911066
128CMYC_18555785_Chip-Seq_ESCs_Mouse0.83377141
129KLF5_25053715_ChIP-Seq_YYC3_Human0.83108367
130P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.83029812
131FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.82961669
132PU1_27457419_Chip-Seq_LIVER_Mouse0.82959189
133UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.82713585
134SUZ12_18555785_Chip-Seq_ESCs_Mouse0.82225241
135RBPJ_21746931_ChIP-Seq_IB4_Human0.82090117
136EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.81880800
137P53_21459846_ChIP-Seq_SAOS-2_Human0.81820742
138GATA4_25053715_ChIP-Seq_YYC3_Human0.80977930
139CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.78788747
140SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.77883924
141JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77159515
142NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.75853886
143NRF2_20460467_ChIP-Seq_MEFs_Mouse0.75853886
144SMC4_20622854_ChIP-Seq_HELA_Human0.74573962
145HNFA_21074721_ChIP-Seq_CACO-2_Human0.74231225
146BCOR_27268052_Chip-Seq_Bcells_Human0.71708995
147CLOCK_20551151_ChIP-Seq_293T_Human0.71411791
148GATA6_25053715_ChIP-Seq_YYC3_Human0.70237977
149CTCF_20526341_ChIP-Seq_ESCs_Human0.69274845
150CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.67946597
151E2F1_20622854_ChIP-Seq_HELA_Human0.67403530
152HTT_18923047_ChIP-ChIP_STHdh_Human0.67128504
153TP53_16413492_ChIP-PET_HCT116_Human0.66610875
154TBX20_22080862_ChIP-Seq_HEART_Mouse0.66028585
155TBX20_22328084_ChIP-Seq_HEART_Mouse0.66028585
156DNAJC2_21179169_ChIP-ChIP_NT2_Human0.65750162
157FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.65178604
158CEBPB_22108803_ChIP-Seq_LS180_Human0.65026473
159SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.63729483
160BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.63276256
161GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.59985065
162RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.59017283
163CBX2_22325352_ChIP-Seq_293T-Rex_Human0.58804034
164PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.57298756
165P300_27058665_Chip-Seq_ZR-75-30cells_Human0.55527492
166SMAD3_21741376_ChIP-Seq_HESCs_Human0.55237489
167PIAS1_25552417_ChIP-Seq_VCAP_Human0.52585566
168VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.52127223
169TAF2_19829295_ChIP-Seq_ESCs_Human0.51730366
170GATA2_21666600_ChIP-Seq_HMVEC_Human0.51203534

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.27065266
2MP0002796_impaired_skin_barrier6.79813426
3MP0003941_abnormal_skin_development4.15810061
4MP0005501_abnormal_skin_physiology4.12636546
5MP0008877_abnormal_DNA_methylation4.05993953
6MP0005275_abnormal_skin_tensile3.54978533
7MP0000566_synostosis3.26770668
8MP0000579_abnormal_nail_morphology3.20227129
9MP0000383_abnormal_hair_follicle3.18981629
10MP0003698_abnormal_male_reproductive3.18216983
11MP0010234_abnormal_vibrissa_follicle3.05820913
12MP0009379_abnormal_foot_pigmentation2.97529370
13MP0001929_abnormal_gametogenesis2.89916643
14MP0004381_abnormal_hair_follicle2.82001327
15MP0001216_abnormal_epidermal_layer2.78606176
16MP0000647_abnormal_sebaceous_gland2.78048336
17MP0010678_abnormal_skin_adnexa2.69813597
18MP0002210_abnormal_sex_determination2.43847911
19MP0000427_abnormal_hair_cycle2.41829603
20MP0010771_integument_phenotype2.39747862
21MP0003011_delayed_dark_adaptation2.30858986
22MP0009780_abnormal_chondrocyte_physiolo2.28245291
23MP0000467_abnormal_esophagus_morphology2.24439902
24MP0002060_abnormal_skin_morphology2.23135223
25MP0002098_abnormal_vibrissa_morphology2.15430281
26MP0002254_reproductive_system_inflammat2.10605304
27MP0000377_abnormal_hair_follicle2.04374560
28MP0003453_abnormal_keratinocyte_physiol2.03981278
29MP0009384_cardiac_valve_regurgitation2.03066816
30MP0008057_abnormal_DNA_replication1.99017356
31MP0001188_hyperpigmentation1.97315027
32MP0004885_abnormal_endolymph1.96941013
33MP0001145_abnormal_male_reproductive1.92026484
34MP0002009_preneoplasia1.69001311
35MP0000653_abnormal_sex_gland1.65642919
36MP0004782_abnormal_surfactant_physiolog1.63168170
37MP0002095_abnormal_skin_pigmentation1.62634507
38MP0004947_skin_inflammation1.57546662
39MP0003191_abnormal_cellular_cholesterol1.54552425
40MP0002161_abnormal_fertility/fecundity1.49376260
41MP0003136_yellow_coat_color1.42398402
42MP0002653_abnormal_ependyma_morphology1.40771795
43MP0000762_abnormal_tongue_morphology1.40255247
44MP0001191_abnormal_skin_condition1.36069941
45MP0005409_darkened_coat_color1.32140620
46MP0002234_abnormal_pharynx_morphology1.31996418
47MP0001346_abnormal_lacrimal_gland1.28661237
48MP0000537_abnormal_urethra_morphology1.26176799
49MP0005646_abnormal_pituitary_gland1.23513363
50MP0003950_abnormal_plasma_membrane1.19243483
51MP0009931_abnormal_skin_appearance1.14200427
52MP0005647_abnormal_sex_gland1.10498520
53MP0000465_gastrointestinal_hemorrhage1.03221611
54MP0003786_premature_aging1.00750748
55MP0001853_heart_inflammation1.00742555
56MP0005023_abnormal_wound_healing1.00187644
57MP0000367_abnormal_coat/_hair0.99301677
58MP0008995_early_reproductive_senescence0.97191622
59MP0002160_abnormal_reproductive_system0.95599069
60MP0000015_abnormal_ear_pigmentation0.93177854
61MP0002282_abnormal_trachea_morphology0.92554499
62MP0009053_abnormal_anal_canal0.87034376
63MP0003566_abnormal_cell_adhesion0.86019845
64MP0001440_abnormal_grooming_behavior0.85889123
65MP0000750_abnormal_muscle_regeneration0.85291230
66MP0005451_abnormal_body_composition0.83343876
67MP0001340_abnormal_eyelid_morphology0.82536341
68MP0005174_abnormal_tail_pigmentation0.80069909
69MP0003880_abnormal_central_pattern0.78653589
70MP0005623_abnormal_meninges_morphology0.77957210
71MP0004134_abnormal_chest_morphology0.75969191
72MP0001851_eye_inflammation0.72112463
73MP0005670_abnormal_white_adipose0.70910629
74MP0005075_abnormal_melanosome_morpholog0.67819556
75MP0002876_abnormal_thyroid_physiology0.62992712
76MP0004858_abnormal_nervous_system0.61575778
77MP0001243_abnormal_dermal_layer0.60896480
78MP0001661_extended_life_span0.60329664
79MP0000627_abnormal_mammary_gland0.59959488
80MP0003938_abnormal_ear_development0.59392574
81MP0002177_abnormal_outer_ear0.56420234
82MP0004043_abnormal_pH_regulation0.56342956
83MP0008007_abnormal_cellular_replicative0.55542071
84MP0003183_abnormal_peptide_metabolism0.54672657
85MP0003279_aneurysm0.54121966
86MP0001984_abnormal_olfaction0.54054835
87MP0008789_abnormal_olfactory_epithelium0.52341486
88MP0003936_abnormal_reproductive_system0.52247585
89MP0005377_hearing/vestibular/ear_phenot0.50766318
90MP0003878_abnormal_ear_physiology0.50766318
91MP0004272_abnormal_basement_membrane0.50087308
92MP0010030_abnormal_orbit_morphology0.49963989
93MP0000432_abnormal_head_morphology0.48819070
94MP0001784_abnormal_fluid_regulation0.48606327
95MP0001542_abnormal_bone_strength0.48584602
96MP0003690_abnormal_glial_cell0.48091781
97MP0003718_maternal_effect0.47319240
98MP0003315_abnormal_perineum_morphology0.46981043
99MP0003045_fibrosis0.45930501
100MP0004185_abnormal_adipocyte_glucose0.43397323
101MP0003705_abnormal_hypodermis_morpholog0.42438039
102MP0003329_amyloid_beta_deposits0.40842621
103MP0002111_abnormal_tail_morphology0.40722769
104MP0001849_ear_inflammation0.40686477
105MP0005499_abnormal_olfactory_system0.40543847
106MP0005394_taste/olfaction_phenotype0.40543847
107MP0002877_abnormal_melanocyte_morpholog0.40050554
108MP0002233_abnormal_nose_morphology0.39936888
109MP0003879_abnormal_hair_cell0.38974934
110MP0003763_abnormal_thymus_physiology0.37708591
111MP0004264_abnormal_extraembryonic_tissu0.37436216
112MP0009046_muscle_twitch0.36687023
113MP0005257_abnormal_intraocular_pressure0.36504571
114MP0005551_abnormal_eye_electrophysiolog0.35619384
115MP0005666_abnormal_adipose_tissue0.35348805
116MP0010352_gastrointestinal_tract_polyps0.35242746
117MP0008260_abnormal_autophagy0.34669859
118MP0003638_abnormal_response/metabolism_0.34133613
119MP0003755_abnormal_palate_morphology0.33928377
120MP0003300_gastrointestinal_ulcer0.32684674
121MP0002133_abnormal_respiratory_system0.32125092
122MP0005388_respiratory_system_phenotype0.32125092
123MP0008004_abnormal_stomach_pH0.32124578
124MP0000470_abnormal_stomach_morphology0.32117172
125MP0005253_abnormal_eye_physiology0.31532774
126MP0002109_abnormal_limb_morphology0.29477557
127MP0005389_reproductive_system_phenotype0.28436283
128MP0001177_atelectasis0.26305380
129MP0001299_abnormal_eye_distance/0.24705739
130MP0001186_pigmentation_phenotype0.23976559
131MP0005503_abnormal_tendon_morphology0.23603367
132MP0004019_abnormal_vitamin_homeostasis0.21934587
133MP0004197_abnormal_fetal_growth/weight/0.21833299
134MP0005193_abnormal_anterior_eye0.20716406
135MP0005076_abnormal_cell_differentiation0.20648015
136MP0002006_tumorigenesis0.20179141
137MP0000428_abnormal_craniofacial_morphol0.19994232
138MP0000678_abnormal_parathyroid_gland0.19074248
139MP0003828_pulmonary_edema0.18308795
140MP0008569_lethality_at_weaning0.17448129
141MP0008438_abnormal_cutaneous_collagen0.15463202
142MP0005508_abnormal_skeleton_morphology0.14959913
143MP0006138_congestive_heart_failure0.14461916
144MP0005197_abnormal_uvea_morphology0.14149164
145MP0000569_abnormal_digit_pigmentation0.13053150

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.43142378
2Absent/shortened dynein arms (HP:0200106)8.09061892
3Dynein arm defect of respiratory motile cilia (HP:0012255)8.09061892
4Abnormal respiratory motile cilium physiology (HP:0012261)6.19334733
5Oral leukoplakia (HP:0002745)5.94184669
6Chronic bronchitis (HP:0004469)5.44819776
7Abnormal respiratory epithelium morphology (HP:0012253)5.36924385
8Abnormal respiratory motile cilium morphology (HP:0005938)5.36924385
9Rhinitis (HP:0012384)5.23904069
10Selective tooth agenesis (HP:0001592)5.08532237
11Abnormal ciliary motility (HP:0012262)4.70941933
12Fragile nails (HP:0001808)4.55429148
13Aplasia involving bones of the upper limbs (HP:0009823)4.49479974
14Aplasia of the phalanges of the hand (HP:0009802)4.49479974
15Aplasia involving bones of the extremities (HP:0009825)4.49479974
16Hypotrichosis (HP:0001006)4.05363384
17Abnormality of the lower motor neuron (HP:0002366)4.05202120
18Nasal polyposis (HP:0100582)4.04587365
19Absent eyelashes (HP:0000561)3.97228379
20Infertility (HP:0000789)3.87080028
21* Palmoplantar keratoderma (HP:0000982)3.85795819
22Dry hair (HP:0011359)3.84578172
23Abnormal hair laboratory examination (HP:0003328)3.70264804
24Plantar hyperkeratosis (HP:0007556)3.68764712
25Parakeratosis (HP:0001036)3.55802437
26Sparse scalp hair (HP:0002209)3.52782313
27Abnormality of nail color (HP:0100643)3.51569457
28Palmoplantar hyperkeratosis (HP:0000972)3.51122046
29Gangrene (HP:0100758)3.35023549
30Abnormality of permanent molar morphology (HP:0011071)3.34415674
31Abnormality of the dental root (HP:0006486)3.34415674
32Taurodontia (HP:0000679)3.34415674
33Gonadotropin excess (HP:0000837)3.31344914
34Short middle phalanx of the 5th finger (HP:0004220)3.28073060
35Palmar hyperkeratosis (HP:0010765)3.27232868
36Hypoplasia of dental enamel (HP:0006297)3.26765811
37Congenital ichthyosiform erythroderma (HP:0007431)3.23066075
38* Hypohidrosis (HP:0000966)3.21922403
39Absent hair (HP:0002298)3.21208194
40Abnormality of molar morphology (HP:0011070)3.21151823
41Abnormality of molar (HP:0011077)3.21151823
42Abnormality of the nasal mucosa (HP:0000433)3.16870666
43Onycholysis (HP:0001806)3.15461284
44Fibular hypoplasia (HP:0003038)3.14705533
45Median cleft lip (HP:0000161)3.11552059
4611 pairs of ribs (HP:0000878)3.09983038
47Abnormality of the dental pulp (HP:0006479)3.06436416
48Woolly hair (HP:0002224)3.02713133
49Amyotrophic lateral sclerosis (HP:0007354)3.02314926
50Follicular hyperkeratosis (HP:0007502)2.98085284
51Lip pit (HP:0100267)2.95673077
52Nephronophthisis (HP:0000090)2.95116049
53Ridged nail (HP:0001807)2.88973407
54Bronchiectasis (HP:0002110)2.88380416
55Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.79300960
56Milia (HP:0001056)2.74639046
57Bronchitis (HP:0012387)2.69142082
58Hypoplastic labia majora (HP:0000059)2.64289841
59Blepharitis (HP:0000498)2.64017960
60Tetraparesis (HP:0002273)2.60199345
61Thick nail (HP:0001805)2.60127705
62Increased IgE level (HP:0003212)2.58049293
63Abnormality of placental membranes (HP:0011409)2.57184037
64Amniotic constriction ring (HP:0009775)2.57184037
65Tubulointerstitial nephritis (HP:0001970)2.52819144
66Hamartoma of the eye (HP:0010568)2.50456137
67Right ventricular cardiomyopathy (HP:0011663)2.44239591
68Abnormality of the renal medulla (HP:0100957)2.41584655
69Pili torti (HP:0003777)2.41132677
70Brittle hair (HP:0002299)2.39257706
71Erythroderma (HP:0001019)2.38196078
72Long nose (HP:0003189)2.36907813
73Impaired proprioception (HP:0010831)2.35421069
74Abnormality of the labia majora (HP:0012881)2.35408321
75Atrophic scars (HP:0001075)2.34575508
76Ectropion (HP:0000656)2.34190740
77Pustule (HP:0200039)2.27899939
78Tubular atrophy (HP:0000092)2.24356388
79Furrowed tongue (HP:0000221)2.23262455
80Eczematoid dermatitis (HP:0000976)2.18564927
81Cutaneous syndactyly (HP:0012725)2.18420003
82Alopecia of scalp (HP:0002293)2.17037848
83Hyperhidrosis (HP:0000975)2.15336549
84Nail dystrophy (HP:0008404)2.14519903
85* Pruritus (HP:0000989)2.14039423
86Hyporeflexia of lower limbs (HP:0002600)2.12421475
87Split foot (HP:0001839)2.09855085
88Renal dysplasia (HP:0000110)2.08319761
89Erythema (HP:0010783)2.07506070
90Broad alveolar ridges (HP:0000187)2.06207063
91Oligodontia (HP:0000677)2.06009866
92Advanced eruption of teeth (HP:0006288)2.05836654
93Xerostomia (HP:0000217)2.05221935
94Aplasia/Hypoplasia of the fibula (HP:0006492)2.05029395
95Upper motor neuron abnormality (HP:0002127)2.05016447
96Laryngomalacia (HP:0001601)2.04383502
97Microglossia (HP:0000171)2.03968854
98Tubulointerstitial abnormality (HP:0001969)2.01246365
99Conical tooth (HP:0000698)2.00815453
100Nasolacrimal duct obstruction (HP:0000579)2.00593742
101Anonychia (HP:0001798)1.99752739
102Melanocytic nevus (HP:0000995)1.99194243
103Natal tooth (HP:0000695)1.99002901
104Abnormal finger flexion creases (HP:0006143)1.98946059
105Dehydration (HP:0001944)1.98009376
106Popliteal pterygium (HP:0009756)1.97547314
107Duplicated collecting system (HP:0000081)1.97450401
108Azoospermia (HP:0000027)1.95931410
109Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.94513544
110Lack of skin elasticity (HP:0100679)1.92987154
111Male infertility (HP:0003251)1.90550867
112Fine hair (HP:0002213)1.87326623
113Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.86757503
114Septate vagina (HP:0001153)1.85587570
115Hypoplastic left heart (HP:0004383)1.83894153
116* Corneal erosion (HP:0200020)1.83354728
117Carious teeth (HP:0000670)1.82967511
118Multifactorial inheritance (HP:0001426)1.81953748
119Recurrent corneal erosions (HP:0000495)1.81788517
120Skin ulcer (HP:0200042)1.81094970
121Abnormal spermatogenesis (HP:0008669)1.81091491
122Abnormal blistering of the skin (HP:0008066)1.80640937
123Acanthosis nigricans (HP:0000956)1.78715060
124Recurrent otitis media (HP:0000403)1.78487255
125Autoamputation (HP:0001218)1.78256942
126Hypergammaglobulinemia (HP:0010702)1.77386985
127Abnormality of secondary sexual hair (HP:0009888)1.77273782
128Abnormality of the axillary hair (HP:0100134)1.77273782
129Sparse eyelashes (HP:0000653)1.77216174
130Hypodontia (HP:0000668)1.74838545
131Abnormality of the phalanges of the 5th finger (HP:0004213)1.74167607
132Premature loss of primary teeth (HP:0006323)1.73886233
133Abnormality of hair growth rate (HP:0011363)1.73696238
134Slow-growing hair (HP:0002217)1.73696238
135Abnormality of the alveolar ridges (HP:0006477)1.72919523
136Postaxial foot polydactyly (HP:0001830)1.70426907
137Short hallux (HP:0010109)1.69738187
138Abnormality of the salivary glands (HP:0010286)1.69240853
139Urticaria (HP:0001025)1.69069436
140Missing ribs (HP:0000921)1.68099226
141Depressed nasal tip (HP:0000437)1.68060163
142Conjunctival hamartoma (HP:0100780)1.67347584
143Abnormality of the renal collecting system (HP:0004742)1.67173137
144Abnormality of the neuromuscular junction (HP:0003398)1.66832802
145Fatigable weakness (HP:0003473)1.66832802
146Hypoalphalipoproteinemia (HP:0003233)1.66582804
147Breast hypoplasia (HP:0003187)1.65470452
148Abnormality of the fingernails (HP:0001231)1.63030754
149Abnormality of the lacrimal duct (HP:0011481)1.61838240
150Curly hair (HP:0002212)1.61138804
151Ventricular tachycardia (HP:0004756)1.60909799
152Corneal dystrophy (HP:0001131)1.59704735

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.65655904
2PDK38.65655904
3PDK26.18187626
4TGFBR15.68697968
5STK245.29240139
6MAP3K63.76981567
7TESK13.15779572
8RIPK12.60665087
9STK392.36677950
10MAP3K92.18354032
11CDC72.06833131
12NEK61.97769420
13PTK2B1.96458212
14WNK41.82135802
15ICK1.80552334
16PNCK1.69606853
17MST41.68477148
18MAP3K21.55618763
19PRKD31.53624432
20MAP3K31.46352279
21FER1.45528439
22EPHA21.44067948
23SGK2231.40701442
24SGK4941.40701442
25SIK11.29327490
26EPHA31.24378795
27CDK121.22579529
28FGFR21.15685646
29MAPK121.14483034
30MST1R1.13357685
31IKBKB1.12376465
32MAP3K11.11313623
33MAPK71.11011314
34TYRO31.10680046
35MAPKAPK31.09558211
36NEK21.04678698
37PIM21.00017481
38LATS20.99941980
39ARAF0.99353856
40STK30.97228869
41ERN10.93488831
42WNK10.91179243
43GRK60.90996116
44MAPK150.90533619
45PRPF4B0.89948585
46BCR0.89094501
47NTRK20.87785184
48NLK0.81743779
49TGFBR20.80695497
50CDK60.80129438
51DYRK1B0.79043797
52GRK10.78783395
53MAPKAPK50.77118437
54KSR20.76710471
55STK380.75862006
56PRKCG0.73270475
57RET0.67383819
58ERBB30.66437752
59BLK0.66114543
60LATS10.65194743
61MAP3K70.64077190
62MET0.64041310
63PDK10.61581319
64PBK0.58176261
65PDGFRA0.57709186
66SGK20.54931518
67MAPKAPK20.54404000
68ADRBK10.53763826
69BMX0.53042713
70DMPK0.51890837
71MAP3K120.50310107
72RIPK40.49830528
73PRKD20.49578440
74SGK30.49472022
75PIK3CG0.48235731
76MAP3K130.47397438
77CASK0.47056921
78SGK10.46173774
79BRD40.44624262
80CCNB10.42876425
81MOS0.42841284
82CSNK1D0.42729160
83NTRK10.42228730
84PRKCE0.38998763
85PRKAA20.38902563
86FGR0.38573123
87YES10.38002973
88TTN0.37420962
89RPS6KB20.37356456
90FGFR10.37263962
91FGFR40.37199541
92TTK0.37047523
93GSK3A0.36317835
94MUSK0.35823461
95PASK0.35695118
96CAMK1G0.33366037
97TRPM70.31868328
98RPS6KA20.30978832
99FRK0.30957360
100EPHB20.30493762
101PAK30.29962664
102DYRK30.29251212
103BMPR1B0.28913765
104PKN10.27676767
105PRKCI0.27629155
106EEF2K0.26505904
107ABL20.26414686
108PIK3CA0.26289553
109JAK30.26257636
110CHEK10.25866226
111KIT0.24990854
112ABL10.24767198
113ATR0.24104633
114BRAF0.24039116
115TNK20.23656201
116PINK10.23476706
117CDC42BPA0.22986242
118MTOR0.22840076
119DDR20.22610378
120MAP2K60.22406740
121PDGFRB0.22310611
122LMTK20.22155114
123DYRK1A0.21706016
124CDK30.21503707
125MAPK90.21274983
126MAP2K40.21062619
127GRK70.20591828
128PTK20.20396675
129IRAK10.20379333
130JAK10.20102212
131AKT30.19560547
132STK100.17834171
133RAF10.17302841
134MAPK80.16876382
135STK38L0.15142894
136OXSR10.14867158
137ATM0.14727005
138PDPK10.14560407
139PTK60.14201561
140EPHB10.13378878
141PRKCA0.12991811
142TAOK10.12938734
143WNK30.12904026
144STK110.12363122
145FGFR30.12298305
146MARK20.11657176
147RPS6KB10.11245613
148PRKACB0.10534614
149PRKCB0.10321911
150CAMK2A0.09696817
151CSNK1E0.09666263
152SRC0.09399989
153MAPK10.08751549
154IGF1R0.08392833
155ROCK10.07339706
156PRKAA10.06975794
157GSK3B0.06747062

Predicted pathways (KEGG)

RankGene SetZ-score
1Dorso-ventral axis formation_Homo sapiens_hsa043204.05724349
2Linoleic acid metabolism_Homo sapiens_hsa005913.42396880
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.39828936
4Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.86956920
5Pyruvate metabolism_Homo sapiens_hsa006202.79471640
6* Sphingolipid metabolism_Homo sapiens_hsa006002.71600998
7Ether lipid metabolism_Homo sapiens_hsa005652.46679967
8Vitamin B6 metabolism_Homo sapiens_hsa007502.33498140
9Fatty acid biosynthesis_Homo sapiens_hsa000612.31628945
10GnRH signaling pathway_Homo sapiens_hsa049122.24629122
11Propanoate metabolism_Homo sapiens_hsa006402.21828953
12Arachidonic acid metabolism_Homo sapiens_hsa005902.13345002
13Glucagon signaling pathway_Homo sapiens_hsa049222.03800965
14Ovarian steroidogenesis_Homo sapiens_hsa049132.02974313
15Basal cell carcinoma_Homo sapiens_hsa052171.92253485
16Basal transcription factors_Homo sapiens_hsa030221.76937627
17Mineral absorption_Homo sapiens_hsa049781.70927551
18Long-term depression_Homo sapiens_hsa047301.69999158
19Fanconi anemia pathway_Homo sapiens_hsa034601.69657856
20Renin secretion_Homo sapiens_hsa049241.67246693
21Fatty acid elongation_Homo sapiens_hsa000621.61727912
22Glycerophospholipid metabolism_Homo sapiens_hsa005641.61082303
23Steroid biosynthesis_Homo sapiens_hsa001001.56221256
24Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.53521124
25Glycerolipid metabolism_Homo sapiens_hsa005611.53293796
26Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.50700612
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.46214394
28Circadian rhythm_Homo sapiens_hsa047101.44163424
29Vitamin digestion and absorption_Homo sapiens_hsa049771.42223257
30Retinol metabolism_Homo sapiens_hsa008301.40164845
31Staphylococcus aureus infection_Homo sapiens_hsa051501.39622840
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.32859379
33Pentose phosphate pathway_Homo sapiens_hsa000301.27157803
34Oocyte meiosis_Homo sapiens_hsa041141.24378027
35Tight junction_Homo sapiens_hsa045301.23477883
36Choline metabolism in cancer_Homo sapiens_hsa052311.23121224
37Serotonergic synapse_Homo sapiens_hsa047261.23071359
38Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.20902900
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.20886854
40ABC transporters_Homo sapiens_hsa020101.20349256
41Selenocompound metabolism_Homo sapiens_hsa004501.19068187
42Inositol phosphate metabolism_Homo sapiens_hsa005621.14463576
43Hedgehog signaling pathway_Homo sapiens_hsa043401.13434249
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05328996
45Amphetamine addiction_Homo sapiens_hsa050311.05297481
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.04309421
47Fat digestion and absorption_Homo sapiens_hsa049751.02727354
48Axon guidance_Homo sapiens_hsa043601.02031363
49ECM-receptor interaction_Homo sapiens_hsa045121.01899259
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.00142231
51Histidine metabolism_Homo sapiens_hsa003400.97105337
52Glioma_Homo sapiens_hsa052140.96181276
53Platelet activation_Homo sapiens_hsa046110.95388418
54Wnt signaling pathway_Homo sapiens_hsa043100.95374322
55Chemical carcinogenesis_Homo sapiens_hsa052040.92970505
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89009103
57MicroRNAs in cancer_Homo sapiens_hsa052060.88212912
58p53 signaling pathway_Homo sapiens_hsa041150.87066698
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86593131
60Acute myeloid leukemia_Homo sapiens_hsa052210.86300951
61VEGF signaling pathway_Homo sapiens_hsa043700.86230251
62Small cell lung cancer_Homo sapiens_hsa052220.86226613
63Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.83861765
64Salivary secretion_Homo sapiens_hsa049700.83708962
65Huntingtons disease_Homo sapiens_hsa050160.83204915
66Phenylalanine metabolism_Homo sapiens_hsa003600.82176582
67Cardiac muscle contraction_Homo sapiens_hsa042600.80362690
68Toxoplasmosis_Homo sapiens_hsa051450.79463807
69Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.78982329
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78760802
71Gastric acid secretion_Homo sapiens_hsa049710.78162711
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.77702543
73Calcium signaling pathway_Homo sapiens_hsa040200.77410720
74Bladder cancer_Homo sapiens_hsa052190.76734519
75Focal adhesion_Homo sapiens_hsa045100.76633168
76Phototransduction_Homo sapiens_hsa047440.74812210
77Melanogenesis_Homo sapiens_hsa049160.74353686
78Hippo signaling pathway_Homo sapiens_hsa043900.74203506
79PPAR signaling pathway_Homo sapiens_hsa033200.71565071
80Thyroid cancer_Homo sapiens_hsa052160.71191272
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70504474
82Pancreatic secretion_Homo sapiens_hsa049720.69775090
83Endocytosis_Homo sapiens_hsa041440.69713736
84Long-term potentiation_Homo sapiens_hsa047200.68767431
85Estrogen signaling pathway_Homo sapiens_hsa049150.68043753
86Notch signaling pathway_Homo sapiens_hsa043300.66666971
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.66576441
88Pertussis_Homo sapiens_hsa051330.65298080
89Glutamatergic synapse_Homo sapiens_hsa047240.63238455
90Protein digestion and absorption_Homo sapiens_hsa049740.60501567
91Legionellosis_Homo sapiens_hsa051340.58410798
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58143332
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56199775
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.55746831
95Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53655977
96Rap1 signaling pathway_Homo sapiens_hsa040150.53323602
97Renal cell carcinoma_Homo sapiens_hsa052110.53198764
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52847404
99Pathways in cancer_Homo sapiens_hsa052000.52263366
100Antigen processing and presentation_Homo sapiens_hsa046120.51983504
101MAPK signaling pathway_Homo sapiens_hsa040100.51782700
102Insulin signaling pathway_Homo sapiens_hsa049100.51233386
103Tyrosine metabolism_Homo sapiens_hsa003500.50106442
104mRNA surveillance pathway_Homo sapiens_hsa030150.49828434
105Adherens junction_Homo sapiens_hsa045200.49682763
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49137407
107* Sphingolipid signaling pathway_Homo sapiens_hsa040710.48533558
108Tuberculosis_Homo sapiens_hsa051520.48214714
109cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48165238
110NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47658172
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47506551
112Fatty acid metabolism_Homo sapiens_hsa012120.46905953
113Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.43364000
114Pancreatic cancer_Homo sapiens_hsa052120.42993337
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41886566
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.40899910
117Proteoglycans in cancer_Homo sapiens_hsa052050.39904397
118Hepatitis C_Homo sapiens_hsa051600.38213860
119Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37224249
120Lysine degradation_Homo sapiens_hsa003100.37081864
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.35641289
122Glutathione metabolism_Homo sapiens_hsa004800.34940308
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.32548515
124Salmonella infection_Homo sapiens_hsa051320.32394618
125Aldosterone synthesis and secretion_Homo sapiens_hsa049250.30687151
126Amoebiasis_Homo sapiens_hsa051460.29362344
127Fatty acid degradation_Homo sapiens_hsa000710.29246596
128Circadian entrainment_Homo sapiens_hsa047130.28710245
129Olfactory transduction_Homo sapiens_hsa047400.28193758
130Influenza A_Homo sapiens_hsa051640.27864202
131AMPK signaling pathway_Homo sapiens_hsa041520.27621587
132ErbB signaling pathway_Homo sapiens_hsa040120.27423156
133Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.27379942
134Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26375512
135AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.25676482
136Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.25285094
137Oxytocin signaling pathway_Homo sapiens_hsa049210.25187788
138Jak-STAT signaling pathway_Homo sapiens_hsa046300.25097266
139Ras signaling pathway_Homo sapiens_hsa040140.22684830
140Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.21656843
141Gap junction_Homo sapiens_hsa045400.19402059
142SNARE interactions in vesicular transport_Homo sapiens_hsa041300.18909321

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