CERS4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)7.09420667
2cilium or flagellum-dependent cell motility (GO:0001539)6.23404916
3cilium movement (GO:0003341)5.21979766
4regulation of short-term neuronal synaptic plasticity (GO:0048172)4.91865048
5neuron cell-cell adhesion (GO:0007158)4.81582290
6protein localization to synapse (GO:0035418)4.79714101
7vocalization behavior (GO:0071625)4.77223943
8ethanol metabolic process (GO:0006067)4.76708896
9primary alcohol catabolic process (GO:0034310)4.42500695
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.35717577
11synaptic vesicle exocytosis (GO:0016079)4.35467155
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.32352006
13motile cilium assembly (GO:0044458)4.31079393
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.22417358
15ethanol oxidation (GO:0006069)4.19066851
16epithelial cilium movement (GO:0003351)4.18911622
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.10310613
18glutamate receptor signaling pathway (GO:0007215)4.03429398
19lung epithelium development (GO:0060428)4.03322186
20phospholipid efflux (GO:0033700)4.03092220
21positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.01877709
22regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.01384722
23regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.98896476
24axoneme assembly (GO:0035082)3.95091833
25presynaptic membrane assembly (GO:0097105)3.91796462
26regulation of glutamate receptor signaling pathway (GO:1900449)3.91362821
27negative regulation of cholesterol transport (GO:0032375)3.88149544
28negative regulation of sterol transport (GO:0032372)3.88149544
29gamma-aminobutyric acid signaling pathway (GO:0007214)3.84786373
30G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.83405705
31erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.80768840
32L-phenylalanine catabolic process (GO:0006559)3.80768840
33long-chain fatty acid biosynthetic process (GO:0042759)3.78029701
34positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.75689237
35vitamin transmembrane transport (GO:0035461)3.74825775
36glyoxylate metabolic process (GO:0046487)3.74340913
37regulation of synaptic vesicle exocytosis (GO:2000300)3.67822301
38membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.64669739
39neuron recognition (GO:0008038)3.64356453
40peptidyl-glutamic acid carboxylation (GO:0017187)3.63416099
41protein carboxylation (GO:0018214)3.63416099
42postsynaptic membrane organization (GO:0001941)3.62659708
43synaptic transmission, glutamatergic (GO:0035249)3.56096916
44serine family amino acid catabolic process (GO:0009071)3.53845421
45glutamate secretion (GO:0014047)3.53325735
46neuron-neuron synaptic transmission (GO:0007270)3.52347203
47drug catabolic process (GO:0042737)3.51939560
48presynaptic membrane organization (GO:0097090)3.48903830
49exogenous drug catabolic process (GO:0042738)3.48432375
50regulation of cholesterol esterification (GO:0010872)3.46989761
51detection of light stimulus involved in visual perception (GO:0050908)3.46050115
52detection of light stimulus involved in sensory perception (GO:0050962)3.46050115
53regulation of protein activation cascade (GO:2000257)3.40594504
54synaptic vesicle docking involved in exocytosis (GO:0016081)3.40402508
55negative regulation of synaptic transmission, GABAergic (GO:0032229)3.40261571
56amino-acid betaine metabolic process (GO:0006577)3.38087984
57regulation of excitatory postsynaptic membrane potential (GO:0060079)3.32941825
58regulation of postsynaptic membrane potential (GO:0060078)3.31275863
59membrane depolarization during action potential (GO:0086010)3.31236689
60L-phenylalanine metabolic process (GO:0006558)3.30722214
61erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.30722214
62synaptic vesicle maturation (GO:0016188)3.27946521
63response to histamine (GO:0034776)3.26716688
64neurotransmitter secretion (GO:0007269)3.26532002
65neuronal action potential propagation (GO:0019227)3.25827630
66regulation of complement activation (GO:0030449)3.25315549
67regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.24403116
68locomotory exploration behavior (GO:0035641)3.23958831
69carnitine metabolic process (GO:0009437)3.23919086
70axonal fasciculation (GO:0007413)3.23123161
71high-density lipoprotein particle remodeling (GO:0034375)3.22702127
72peptidyl-tyrosine autophosphorylation (GO:0038083)3.21078826
73membrane hyperpolarization (GO:0060081)3.19305766
74regulation of synaptic vesicle transport (GO:1902803)3.19082546
75pyrimidine nucleobase catabolic process (GO:0006208)3.18888463
76reverse cholesterol transport (GO:0043691)3.18758568
77exploration behavior (GO:0035640)3.18131991
78synapse assembly (GO:0007416)3.16828377
79regulation of synaptic transmission, glutamatergic (GO:0051966)3.13843132
80transmission of nerve impulse (GO:0019226)3.13435733
81regulation of cholesterol biosynthetic process (GO:0045540)3.12898149
82regulation of vesicle fusion (GO:0031338)3.11971440
83cerebellar Purkinje cell differentiation (GO:0021702)3.11690268
84phenylpropanoid metabolic process (GO:0009698)3.09601145
85startle response (GO:0001964)3.09525357
86fatty acid elongation (GO:0030497)3.09492385
87positive regulation of synapse assembly (GO:0051965)3.09117327
88regulation of neurotransmitter secretion (GO:0046928)3.08880692
89dendritic spine morphogenesis (GO:0060997)3.08828791
90membrane depolarization (GO:0051899)3.08593698
91neurotransmitter transport (GO:0006836)3.08349925
92positive regulation of synaptic transmission, GABAergic (GO:0032230)3.07060894
93cholesterol efflux (GO:0033344)3.05684327
94negative regulation of immunoglobulin mediated immune response (GO:0002890)3.04614589
95negative regulation of B cell mediated immunity (GO:0002713)3.04614589
96response to pheromone (GO:0019236)3.04040418
97regulation of glutamate secretion (GO:0014048)3.03891385
98negative regulation of lipase activity (GO:0060192)3.03736508
99neurotransmitter-gated ion channel clustering (GO:0072578)3.03086172
100positive regulation of potassium ion transmembrane transport (GO:1901381)3.02320873
101positive regulation of membrane potential (GO:0045838)3.02109346
102long-term memory (GO:0007616)3.00925023
103plasma lipoprotein particle assembly (GO:0034377)3.00653572
104regulation of long-term neuronal synaptic plasticity (GO:0048169)3.00494507
105regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.00431271
106left/right pattern formation (GO:0060972)3.00052363
107regulation of apoptotic cell clearance (GO:2000425)2.98951339
108proline metabolic process (GO:0006560)2.97327132
109regulation of fibrinolysis (GO:0051917)2.97309361
110regulation of rhodopsin mediated signaling pathway (GO:0022400)2.97201727
111righting reflex (GO:0060013)2.95812083
112long-term synaptic potentiation (GO:0060291)2.95278327
113multicellular organismal water homeostasis (GO:0050891)2.94647166
114positive regulation of synapse maturation (GO:0090129)2.94466536
115negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.94381724
116cellular potassium ion homeostasis (GO:0030007)2.93345827
117regulation of neuronal synaptic plasticity (GO:0048168)2.93187424
118triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.92662973
119regulation of respiratory system process (GO:0044065)2.92550253
120synaptic vesicle endocytosis (GO:0048488)2.89301838
121fear response (GO:0042596)2.88345164
122rhodopsin mediated signaling pathway (GO:0016056)2.87947533
123positive regulation of neurotransmitter transport (GO:0051590)2.87511195
124regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.87048689
125L-serine metabolic process (GO:0006563)2.87013930
126regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.86409162
127microtubule bundle formation (GO:0001578)2.85881270
128regulation of neurotransmitter transport (GO:0051588)2.85106345
129behavioral fear response (GO:0001662)2.84376102
130behavioral defense response (GO:0002209)2.84376102
131innervation (GO:0060384)2.83635062
132epoxygenase P450 pathway (GO:0019373)2.83327586
133negative regulation of cytosolic calcium ion concentration (GO:0051481)2.83157089
134regulation of cholesterol metabolic process (GO:0090181)2.82589479
135detection of calcium ion (GO:0005513)2.82293498
136complement activation, alternative pathway (GO:0006957)2.82093387
137regulation of synapse maturation (GO:0090128)2.81845067
138cell migration in hindbrain (GO:0021535)2.81414440
139establishment of apical/basal cell polarity (GO:0035089)2.81312034
140positive regulation of neurotransmitter secretion (GO:0001956)2.79615664
141retinal cone cell development (GO:0046549)2.79193120
142cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.78847813
143behavioral response to ethanol (GO:0048149)2.77869643
144glutamate metabolic process (GO:0006536)2.77533188
145regulation of gene silencing by RNA (GO:0060966)2.77250931
146regulation of posttranscriptional gene silencing (GO:0060147)2.77250931
147regulation of gene silencing by miRNA (GO:0060964)2.77250931
148regulation of respiratory gaseous exchange (GO:0043576)2.77193044
149retinal rod cell development (GO:0046548)2.75693658
150neuronal ion channel clustering (GO:0045161)2.74831407
151behavioral response to nicotine (GO:0035095)2.74350290
152layer formation in cerebral cortex (GO:0021819)2.73441329
153cellular response to epinephrine stimulus (GO:0071872)2.73054343
154striatum development (GO:0021756)2.72559412
155calcium ion import (GO:0070509)2.72274323
156eye photoreceptor cell development (GO:0042462)2.72203808
157synaptic transmission (GO:0007268)2.71544890
158plasma lipoprotein particle remodeling (GO:0034369)2.70501742
159protein-lipid complex remodeling (GO:0034368)2.70501742
160macromolecular complex remodeling (GO:0034367)2.70501742
161regulation of protein kinase A signaling (GO:0010738)2.70179547
162response to misfolded protein (GO:0051788)2.67319567
163establishment of monopolar cell polarity (GO:0061162)2.65515343
164establishment or maintenance of monopolar cell polarity (GO:0061339)2.65515343
165water homeostasis (GO:0030104)2.63056264
166biotin metabolic process (GO:0006768)2.57378009
167fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.55397447
168negative regulation of fibrinolysis (GO:0051918)2.54648750
169L-alpha-amino acid transmembrane transport (GO:1902475)2.52939698
170aldehyde catabolic process (GO:0046185)2.49072489
171regulation of autophagic vacuole assembly (GO:2000785)2.48240079
172nucleobase catabolic process (GO:0046113)2.46133393
173blood coagulation, intrinsic pathway (GO:0007597)2.46098708
174regulation of cholesterol homeostasis (GO:2000188)2.46001341
175apical protein localization (GO:0045176)2.45769059
176bile acid biosynthetic process (GO:0006699)2.45505499
177acetyl-CoA metabolic process (GO:0006084)2.45035166
178sodium ion homeostasis (GO:0055078)2.44650617
179phosphatidylethanolamine biosynthetic process (GO:0006646)2.43362269
180regulation of bile acid biosynthetic process (GO:0070857)2.42975678
181regulation of humoral immune response (GO:0002920)2.42653015
182primary alcohol metabolic process (GO:0034308)2.42366627
183cell-cell junction maintenance (GO:0045217)2.42173366
184protein-lipid complex assembly (GO:0065005)2.41579597
185intestinal cholesterol absorption (GO:0030299)2.41448275
186protein localization to cilium (GO:0061512)2.41336219
187urea metabolic process (GO:0019627)2.40698878
188alpha-amino acid catabolic process (GO:1901606)2.39551727
189negative regulation of humoral immune response (GO:0002921)2.39483293
190positive regulation of lipoprotein lipase activity (GO:0051006)2.38736748
191positive regulation of triglyceride lipase activity (GO:0061365)2.38736748
192axon ensheathment in central nervous system (GO:0032291)2.38014662

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.57932134
2GBX2_23144817_ChIP-Seq_PC3_Human3.98791799
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.82157777
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.98043356
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.95869554
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.90646449
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.82762212
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.66441685
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.55891740
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.55560002
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.53466428
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.50835862
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.50784412
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.50784412
15TAF15_26573619_Chip-Seq_HEK293_Human2.50759902
16CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.49802891
17EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.48475735
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.47708353
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.41923734
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.40693970
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.39862017
22TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.35050998
23LXR_22292898_ChIP-Seq_THP-1_Human2.26559174
24MTF2_20144788_ChIP-Seq_MESCs_Mouse2.25744675
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.23186192
26ESR2_21235772_ChIP-Seq_MCF-7_Human2.19500671
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.17692264
28REST_21632747_ChIP-Seq_MESCs_Mouse2.14827256
29ZFP57_27257070_Chip-Seq_ESCs_Mouse2.14598379
30EZH2_27294783_Chip-Seq_ESCs_Mouse2.13996346
31RXR_22158963_ChIP-Seq_LIVER_Mouse2.13780437
32SMC4_20622854_ChIP-Seq_HELA_Human2.12367263
33AR_21572438_ChIP-Seq_LNCaP_Human2.09348230
34SUZ12_27294783_Chip-Seq_ESCs_Mouse2.09267822
35BMI1_23680149_ChIP-Seq_NPCS_Mouse2.08142625
36CTBP1_25329375_ChIP-Seq_LNCAP_Human2.05582322
37CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05230973
38RNF2_27304074_Chip-Seq_ESCs_Mouse2.03621145
39ZFP281_18757296_ChIP-ChIP_E14_Mouse2.01482582
40PPARA_22158963_ChIP-Seq_LIVER_Mouse1.97653707
41* DROSHA_22980978_ChIP-Seq_HELA_Human1.94498665
42CTCF_27219007_Chip-Seq_Bcells_Human1.94044667
43P68_20966046_ChIP-Seq_HELA_Human1.91292728
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.91012155
45MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.88907728
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.81838156
47SMAD4_21799915_ChIP-Seq_A2780_Human1.80621288
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.77331461
49P300_19829295_ChIP-Seq_ESCs_Human1.76921256
50DNAJC2_21179169_ChIP-ChIP_NT2_Human1.75191189
51ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.74140646
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.73722555
53CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.71415991
54ESR1_21235772_ChIP-Seq_MCF-7_Human1.70883350
55KDM2B_26808549_Chip-Seq_SUP-B15_Human1.69574202
56CREB1_26743006_Chip-Seq_LNCaP_Human1.69033881
57ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.67059107
58PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.66943965
59REST_18959480_ChIP-ChIP_MESCs_Mouse1.66469622
60NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.66048914
61SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66030521
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65971410
63SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.64876264
64RACK7_27058665_Chip-Seq_MCF-7_Human1.64549435
65EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.64079127
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.60921818
67IGF1R_20145208_ChIP-Seq_DFB_Human1.59738879
68SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.59653883
69KDM2B_26808549_Chip-Seq_K562_Human1.53088382
70RARB_27405468_Chip-Seq_BRAIN_Mouse1.51210164
71FUS_26573619_Chip-Seq_HEK293_Human1.50489409
72ESR1_20079471_ChIP-ChIP_T-47D_Human1.48513176
73FOXA2_19822575_ChIP-Seq_HepG2_Human1.47019408
74SMAD_19615063_ChIP-ChIP_OVARY_Human1.46569577
75SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.45717289
76RUNX1_27514584_Chip-Seq_MCF-7_Human1.44138473
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.43931234
78RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.43379033
79SA1_27219007_Chip-Seq_ERYTHROID_Human1.43195520
80SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.43021351
81CDX2_19796622_ChIP-Seq_MESCs_Mouse1.42602006
82RNF2_27304074_Chip-Seq_NSC_Mouse1.42111307
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41723425
84AR_25329375_ChIP-Seq_VCAP_Human1.40873177
85TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39895701
86LXR_22158963_ChIP-Seq_LIVER_Mouse1.39575153
87CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.39041587
88ELF1_20517297_ChIP-Seq_JURKAT_Human1.37540865
89RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.34723717
90CTCF_20526341_ChIP-Seq_ESCs_Human1.33658694
91PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.32485166
92BCOR_27268052_Chip-Seq_Bcells_Human1.32106050
93VDR_22108803_ChIP-Seq_LS180_Human1.31620581
94TP63_22573176_ChIP-Seq_HFKS_Human1.31462402
95CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.29504257
96CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29502147
97RARB_24833708_ChIP-Seq_LIVER_Mouse1.29381548
98CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.27527373
99PHF8_20622854_ChIP-Seq_HELA_Human1.26976898
100OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26252566
101ZNF274_21170338_ChIP-Seq_K562_Hela1.26205483
102KDM2B_26808549_Chip-Seq_DND41_Human1.26043393
103ARNT_22903824_ChIP-Seq_MCF-7_Human1.25914784
104GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25913229
105TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.25390279
106EGR1_23403033_ChIP-Seq_LIVER_Mouse1.25135366
107UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24971795
108SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24956038
109RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.23340708
110NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.23184108
111OCT4_19829295_ChIP-Seq_ESCs_Human1.22793488
112AHR_22903824_ChIP-Seq_MCF-7_Human1.22555267
113NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20337382
114SOX2_21211035_ChIP-Seq_LN229_Gbm1.20140618
115BCAT_22108803_ChIP-Seq_LS180_Human1.19629521
116E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.18866224
117CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.18772251
118BCL6_27268052_Chip-Seq_Bcells_Human1.18745915
119P53_22127205_ChIP-Seq_FIBROBLAST_Human1.18650296
120OCT4_20526341_ChIP-Seq_ESCs_Human1.18392488
121SA1_27219007_Chip-Seq_Bcells_Human1.17573382
122SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17539172
123TCF7_22412390_ChIP-Seq_EML_Mouse1.17536052
124DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.17331155
125STAT3_23295773_ChIP-Seq_U87_Human1.17294557
126SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.15675858
127TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15109885
128E2F1_20622854_ChIP-Seq_HELA_Human1.14567307
129RING1B_27294783_Chip-Seq_ESCs_Mouse1.14487635
130ER_23166858_ChIP-Seq_MCF-7_Human1.14406122
131YY1_22570637_ChIP-Seq_MALME-3M_Human1.14316054
132KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.13267173
133TCF4_23295773_ChIP-Seq_U87_Human1.12908982
134AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12015572
135TET1_21490601_ChIP-Seq_MESCs_Mouse1.11755645
136TP53_18474530_ChIP-ChIP_U2OS_Human1.11529626
137PRDM14_20953172_ChIP-Seq_ESCs_Human1.11265523
138NANOG_18555785_Chip-Seq_ESCs_Mouse1.11247274
139TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09297704
140POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09297704
141RUNX2_22187159_ChIP-Seq_PCA_Human1.09075794
142PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08341654
143NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.08168214
144TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06885320
145MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06648675
146OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.06222535
147ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.05826748
148EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04912177
149AR_19668381_ChIP-Seq_PC3_Human1.04337437
150RARA_24833708_ChIP-Seq_LIVER_Mouse1.03839223
151E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.02222517
152TET1_21451524_ChIP-Seq_MESCs_Mouse1.02138239
153VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.02133312
154SOX3_22085726_ChIP-Seq_NPCs_Mouse1.01455582
155FLI1_27457419_Chip-Seq_LIVER_Mouse1.01330410
156ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01268264
157MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00560914
158TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99103464
159ZFP281_27345836_Chip-Seq_ESCs_Mouse0.98647233
160E2F1_18555785_Chip-Seq_ESCs_Mouse0.98472905
161EWS_26573619_Chip-Seq_HEK293_Human0.97792460
162YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96932217
163KDM2B_26808549_Chip-Seq_REH_Human0.96844128
164SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.96062584
165P63_26484246_Chip-Seq_KERATINOCYTES_Human0.95792618
166NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95283475
167RING1B_27294783_Chip-Seq_NPCs_Mouse0.95235997
168POU5F1_16518401_ChIP-PET_MESCs_Mouse0.94872228
169RXRA_24833708_ChIP-Seq_LIVER_Mouse0.94819258
170ERG_21242973_ChIP-ChIP_JURKAT_Human0.93894641
171GATA1_19941827_ChIP-Seq_MEL_Mouse0.93604136
172MYC_27129775_Chip-Seq_CORNEA_Mouse0.93241350
173FLI1_21867929_ChIP-Seq_CD8_Mouse0.92942862
174P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.92322108
175FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.92225697
176JUN_21703547_ChIP-Seq_K562_Human0.92156408
177SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92155175
178CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91862653
179TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.91480349
180P53_22387025_ChIP-Seq_ESCs_Mouse0.91322376
181NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.91281608
182RAD21_21589869_ChIP-Seq_MESCs_Mouse0.91105503
183SMAD3_21741376_ChIP-Seq_ESCs_Human0.90527626
184CMYC_18555785_Chip-Seq_ESCs_Mouse0.90511711
185EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.89730873
186ERA_21632823_ChIP-Seq_H3396_Human0.88944608
187SMAD3_21741376_ChIP-Seq_HESCs_Human0.88200579

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.61222223
2MP0004859_abnormal_synaptic_plasticity3.90183735
3MP0002653_abnormal_ependyma_morphology3.50830945
4MP0003635_abnormal_synaptic_transmissio3.16354445
5MP0003878_abnormal_ear_physiology3.14800954
6MP0005377_hearing/vestibular/ear_phenot3.14800954
7MP0008875_abnormal_xenobiotic_pharmacok3.13082404
8MP0005423_abnormal_somatic_nervous3.03164150
9MP0001968_abnormal_touch/_nociception2.95059785
10MP0009745_abnormal_behavioral_response2.93043634
11MP0000566_synostosis2.86658767
12MP0002139_abnormal_hepatobiliary_system2.79388732
13MP0005551_abnormal_eye_electrophysiolog2.78405026
14MP0002254_reproductive_system_inflammat2.76219909
15MP0006276_abnormal_autonomic_nervous2.75608205
16MP0005365_abnormal_bile_salt2.70492191
17MP0004133_heterotaxia2.67648114
18MP0002064_seizures2.61318280
19MP0002063_abnormal_learning/memory/cond2.53274812
20MP0004270_analgesia2.51983413
21MP0001501_abnormal_sleep_pattern2.43094907
22MP0002572_abnormal_emotion/affect_behav2.42462027
23MP0003011_delayed_dark_adaptation2.40874449
24MP0002736_abnormal_nociception_after2.39908532
25MP0002822_catalepsy2.37250771
26MP0002272_abnormal_nervous_system2.34886765
27MP0009046_muscle_twitch2.33240301
28MP0002734_abnormal_mechanical_nocicepti2.32602843
29MP0002735_abnormal_chemical_nociception2.30661284
30MP0001188_hyperpigmentation2.24898923
31MP0001486_abnormal_startle_reflex2.19805984
32MP0001984_abnormal_olfaction2.15022919
33MP0001440_abnormal_grooming_behavior2.02274870
34MP0006072_abnormal_retinal_apoptosis2.02232066
35MP0003195_calcinosis2.00607347
36MP0002067_abnormal_sensory_capabilities1.96851008
37MP0003329_amyloid_beta_deposits1.84022550
38MP0002638_abnormal_pupillary_reflex1.83150510
39MP0000751_myopathy1.82865900
40MP0005253_abnormal_eye_physiology1.81647090
41MP0001970_abnormal_pain_threshold1.80096702
42MP0005085_abnormal_gallbladder_physiolo1.77589182
43MP0002733_abnormal_thermal_nociception1.74920094
44MP0002184_abnormal_innervation1.73968601
45MP0001529_abnormal_vocalization1.72383246
46MP0004264_abnormal_extraembryonic_tissu1.63809945
47MP0010329_abnormal_lipoprotein_level1.63547483
48MP0001905_abnormal_dopamine_level1.63499521
49MP0001502_abnormal_circadian_rhythm1.61783014
50MP0001666_abnormal_nutrient_absorption1.60936200
51MP0002557_abnormal_social/conspecific_i1.60396154
52MP0000778_abnormal_nervous_system1.59229232
53MP0005646_abnormal_pituitary_gland1.58765793
54MP0003122_maternal_imprinting1.58341833
55MP0005386_behavior/neurological_phenoty1.56115513
56MP0004924_abnormal_behavior1.56115513
57MP0004043_abnormal_pH_regulation1.55990284
58MP0003787_abnormal_imprinting1.54274969
59MP0005645_abnormal_hypothalamus_physiol1.52918956
60MP0008569_lethality_at_weaning1.48136419
61MP0010386_abnormal_urinary_bladder1.44258848
62MP0005409_darkened_coat_color1.40151293
63MP0004142_abnormal_muscle_tone1.40066221
64MP0004215_abnormal_myocardial_fiber1.38495921
65MP0002132_abnormal_respiratory_system1.37113185
66MP0003172_abnormal_lysosome_physiology1.34840919
67MP0002837_dystrophic_cardiac_calcinosis1.33338893
68MP0004019_abnormal_vitamin_homeostasis1.31332612
69MP0002882_abnormal_neuron_morphology1.30781919
70MP0002249_abnormal_larynx_morphology1.29616646
71MP0004145_abnormal_muscle_electrophysio1.28762917
72MP0006292_abnormal_olfactory_placode1.24971647
73MP0005499_abnormal_olfactory_system1.22368508
74MP0005394_taste/olfaction_phenotype1.22368508
75MP0010234_abnormal_vibrissa_follicle1.19673646
76MP0009672_abnormal_birth_weight1.18602255
77MP0002089_abnormal_postnatal_growth/wei1.17379346
78MP0008260_abnormal_autophagy1.17005200
79MP0009840_abnormal_foam_cell1.15211111
80MP0009780_abnormal_chondrocyte_physiolo1.15081744
81MP0003123_paternal_imprinting1.14421662
82MP0003136_yellow_coat_color1.13925319
83MP0002752_abnormal_somatic_nervous1.13221632
84MP0003890_abnormal_embryonic-extraembry1.12995101
85MP0002090_abnormal_vision1.12881871
86MP0004858_abnormal_nervous_system1.12406929
87MP0003879_abnormal_hair_cell1.11399915
88MP0003690_abnormal_glial_cell1.11298321
89MP0004085_abnormal_heartbeat1.10936546
90MP0009379_abnormal_foot_pigmentation1.09295420
91MP0000604_amyloidosis1.08201207
92MP0002066_abnormal_motor_capabilities/c1.06264525
93MP0002909_abnormal_adrenal_gland1.05150404
94MP0004811_abnormal_neuron_physiology1.05085341
95MP0002229_neurodegeneration1.01758655
96MP0000631_abnormal_neuroendocrine_gland1.00865966
97MP0002118_abnormal_lipid_homeostasis0.99938897
98MP0000955_abnormal_spinal_cord0.98237631
99MP0002102_abnormal_ear_morphology0.97104331
100MP0002876_abnormal_thyroid_physiology0.96218868
101MP0001986_abnormal_taste_sensitivity0.95598859
102MP0005360_urolithiasis0.95039650
103MP0005220_abnormal_exocrine_pancreas0.94837142
104MP0003137_abnormal_impulse_conducting0.94686842
105MP0004742_abnormal_vestibular_system0.92756394
106MP0005195_abnormal_posterior_eye0.91749208
107MP0002098_abnormal_vibrissa_morphology0.89009205
108MP0004484_altered_response_of0.88859251
109MP0005075_abnormal_melanosome_morpholog0.88712420
110MP0003938_abnormal_ear_development0.87888260
111MP0001963_abnormal_hearing_physiology0.86244653
112MP0009278_abnormal_bone_marrow0.84079568
113MP0008872_abnormal_physiological_respon0.82327856
114MP0008789_abnormal_olfactory_epithelium0.80815129
115MP0005332_abnormal_amino_acid0.80358221
116MP0000383_abnormal_hair_follicle0.80107532
117MP0005167_abnormal_blood-brain_barrier0.78412710
118MP0004782_abnormal_surfactant_physiolog0.78247519
119MP0000013_abnormal_adipose_tissue0.77761444
120MP0002152_abnormal_brain_morphology0.77602323
121MP0001664_abnormal_digestion0.76595311
122MP0002069_abnormal_eating/drinking_beha0.76460618
123MP0004885_abnormal_endolymph0.76250356
124MP0001764_abnormal_homeostasis0.75764652
125MP0009703_decreased_birth_body0.75568574
126MP0003633_abnormal_nervous_system0.74981379
127MP0002751_abnormal_autonomic_nervous0.73495520
128MP0000026_abnormal_inner_ear0.72516754
129MP0005647_abnormal_sex_gland0.72417162
130MP0003634_abnormal_glial_cell0.72032624
131MP0008995_early_reproductive_senescence0.70913339
132MP0002796_impaired_skin_barrier0.70557836
133MP0004036_abnormal_muscle_relaxation0.70504526
134MP0005620_abnormal_muscle_contractility0.70101877
135MP0005535_abnormal_body_temperature0.69817847
136MP0003119_abnormal_digestive_system0.67494712
137MP0003121_genomic_imprinting0.66049495
138MP0004381_abnormal_hair_follicle0.62793763
139MP0002332_abnormal_exercise_endurance0.62656735
140MP0003183_abnormal_peptide_metabolism0.62015675
141MP0002127_abnormal_cardiovascular_syste0.60625682
142MP0003950_abnormal_plasma_membrane0.60196731
143MP0003631_nervous_system_phenotype0.59756117
144MP0005379_endocrine/exocrine_gland_phen0.56223834
145MP0008874_decreased_physiological_sensi0.54851579
146MP0005595_abnormal_vascular_smooth0.52870106

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.88996900
2Abnormal respiratory motile cilium morphology (HP:0005938)6.50591130
3Abnormal respiratory epithelium morphology (HP:0012253)6.50591130
4Abnormal respiratory motile cilium physiology (HP:0012261)5.90699332
5Focal motor seizures (HP:0011153)5.87408651
6Rhinitis (HP:0012384)5.58527418
7Chronic bronchitis (HP:0004469)5.25892417
8Congenital stationary night blindness (HP:0007642)5.11458695
9Febrile seizures (HP:0002373)5.03535591
10Epileptic encephalopathy (HP:0200134)4.44500857
11Deep venous thrombosis (HP:0002625)4.42131635
12Bronchiectasis (HP:0002110)4.36936693
13Focal seizures (HP:0007359)4.27865901
14Atonic seizures (HP:0010819)4.26980950
15Progressive cerebellar ataxia (HP:0002073)4.12051155
16Recurrent sinusitis (HP:0011108)4.07158449
17Myokymia (HP:0002411)4.03186012
18Visual hallucinations (HP:0002367)3.87650151
19Absence seizures (HP:0002121)3.64903675
20Nasal polyposis (HP:0100582)3.58651992
21Abnormal rod and cone electroretinograms (HP:0008323)3.52557375
22Prolonged partial thromboplastin time (HP:0003645)3.51095402
23Abnormality of monocarboxylic acid metabolism (HP:0010996)3.48282985
24Bony spicule pigmentary retinopathy (HP:0007737)3.45135185
25Broad-based gait (HP:0002136)3.44781089
26Dialeptic seizures (HP:0011146)3.33290747
27Hypothermia (HP:0002045)3.29484129
28Central scotoma (HP:0000603)3.25163139
29Recurrent otitis media (HP:0000403)3.15409758
30Generalized tonic-clonic seizures (HP:0002069)3.08127326
31Bronchomalacia (HP:0002780)3.03317433
32Absent rod-and cone-mediated responses on ERG (HP:0007688)2.96079776
33Hyperventilation (HP:0002883)2.93706029
34Abnormality of macular pigmentation (HP:0008002)2.92189049
35Severe visual impairment (HP:0001141)2.92007205
36Obstructive sleep apnea (HP:0002870)2.88397269
37Amblyopia (HP:0000646)2.78339658
38Complement deficiency (HP:0004431)2.76512083
39Bronchitis (HP:0012387)2.65477098
40Decreased central vision (HP:0007663)2.63902535
41Gait imbalance (HP:0002141)2.59817369
42Abnormality of the nasal mucosa (HP:0000433)2.58794903
43Attenuation of retinal blood vessels (HP:0007843)2.58361437
44Gaze-evoked nystagmus (HP:0000640)2.54621206
45Hyperglycinuria (HP:0003108)2.54601204
46Polyphagia (HP:0002591)2.49486101
47Truncal ataxia (HP:0002078)2.47485938
48Hepatoblastoma (HP:0002884)2.46616369
49Drooling (HP:0002307)2.45827094
50Excessive salivation (HP:0003781)2.45827094
51Scotoma (HP:0000575)2.45618747
52Exotropia (HP:0000577)2.45313157
53Limb dystonia (HP:0002451)2.43236373
54Joint hemorrhage (HP:0005261)2.39406585
55Hypoventilation (HP:0002791)2.37157905
56Optic disc pallor (HP:0000543)2.36957250
57Prolonged QT interval (HP:0001657)2.36620219
58Abnormality of aromatic amino acid family metabolism (HP:0004338)2.36543082
59Hemiparesis (HP:0001269)2.33385876
60Abnormality of serine family amino acid metabolism (HP:0010894)2.31674698
61Abnormality of glycine metabolism (HP:0010895)2.31674698
62Protruding tongue (HP:0010808)2.30014744
63Medial flaring of the eyebrow (HP:0010747)2.29722195
64Syncope (HP:0001279)2.29595361
65Acute necrotizing encephalopathy (HP:0006965)2.29541377
66Congenital primary aphakia (HP:0007707)2.28829333
67Bifid scrotum (HP:0000048)2.26904669
68Increased corneal curvature (HP:0100692)2.24305344
69Keratoconus (HP:0000563)2.24305344
70Occipital encephalocele (HP:0002085)2.23841573
71Progressive inability to walk (HP:0002505)2.21971759
72Abnormal eating behavior (HP:0100738)2.21140252
73Retinal dysplasia (HP:0007973)2.20862339
74Sleep apnea (HP:0010535)2.20736341
75Nephrogenic diabetes insipidus (HP:0009806)2.20482715
76Genetic anticipation (HP:0003743)2.19705285
77Abnormal EKG (HP:0003115)2.15192591
78Dysdiadochokinesis (HP:0002075)2.14412348
79Choanal stenosis (HP:0000452)2.13928952
80Progressive macrocephaly (HP:0004481)2.11631468
81Diplopia (HP:0000651)2.10827477
82Abnormality of binocular vision (HP:0011514)2.10827477
83Abnormal hair whorl (HP:0010721)2.10634796
84Intrahepatic cholestasis (HP:0001406)2.09969883
85Infertility (HP:0000789)2.09484744
86Anxiety (HP:0000739)2.08997881
87Action tremor (HP:0002345)2.07891365
88Chronic sinusitis (HP:0011109)2.07489980
89Esotropia (HP:0000565)2.05445003
90Abnormal mitochondria in muscle tissue (HP:0008316)2.04128325
91Hyperglycinemia (HP:0002154)2.03277763
92Atelectasis (HP:0100750)2.02692306
93Hyperthyroidism (HP:0000836)2.01343159
94Genital tract atresia (HP:0001827)2.01221297
95Decreased circulating renin level (HP:0003351)1.99947462
96Ventricular fibrillation (HP:0001663)1.99706796
97Abnormality of the aortic arch (HP:0012303)1.99633805
98Inability to walk (HP:0002540)1.99425038
99Abnormal ciliary motility (HP:0012262)1.99379470
100Hand muscle atrophy (HP:0009130)1.98668884
101Septo-optic dysplasia (HP:0100842)1.97802785
102Primary atrial arrhythmia (HP:0001692)1.95104355
103Partial agenesis of the corpus callosum (HP:0001338)1.94592344
104Absent speech (HP:0001344)1.94479277
105Cystic liver disease (HP:0006706)1.94443215
106Absent/shortened dynein arms (HP:0200106)1.93946462
107Dynein arm defect of respiratory motile cilia (HP:0012255)1.93946462
108Stridor (HP:0010307)1.93367006
109Vaginal atresia (HP:0000148)1.93062988
110Hyperactive renin-angiotensin system (HP:0000841)1.92179284
111Ulnar claw (HP:0001178)1.91248091
112Poor eye contact (HP:0000817)1.90880911
113Abolished electroretinogram (ERG) (HP:0000550)1.90513225
114Bradycardia (HP:0001662)1.90213318
115Atrial fibrillation (HP:0005110)1.90131578
116Aplasia/Hypoplasia of the brainstem (HP:0007362)1.89553759
117Hypoplasia of the brainstem (HP:0002365)1.89553759
118Chorioretinal atrophy (HP:0000533)1.89544875
119Increased IgE level (HP:0003212)1.87969598
120Abnormality of salivation (HP:0100755)1.87162298
121Ankle clonus (HP:0011448)1.86683174
122Chronic hepatic failure (HP:0100626)1.86636748
123Supraventricular tachycardia (HP:0004755)1.85420167
124Chronic otitis media (HP:0000389)1.84504699
125Pendular nystagmus (HP:0012043)1.84131658
126Anosmia (HP:0000458)1.83570650
127Systemic lupus erythematosus (HP:0002725)1.83510030
128Dysmetria (HP:0001310)1.83415943
129Narrow nasal bridge (HP:0000446)1.83346816
130Abnormality of complement system (HP:0005339)1.83112171
131Dyschromatopsia (HP:0007641)1.80569931
132Flat acetabular roof (HP:0003180)1.80225143
133Sudden death (HP:0001699)1.80186617
134Supraventricular arrhythmia (HP:0005115)1.78828712
135Alacrima (HP:0000522)1.77808335
136Xanthomatosis (HP:0000991)1.77365119
137Muscle hypertrophy of the lower extremities (HP:0008968)1.77289485
138Molar tooth sign on MRI (HP:0002419)1.76274735
139Abnormality of midbrain morphology (HP:0002418)1.76274735
140Mitochondrial inheritance (HP:0001427)1.76213349
141Hypobetalipoproteinemia (HP:0003563)1.75362713
142Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.74650725
143Glomerulonephritis (HP:0000099)1.74237655
144Severe Myopia (HP:0011003)1.73606305
145Specific learning disability (HP:0001328)1.73043124
146Aplasia/Hypoplasia of the lens (HP:0008063)1.72887310
147Agitation (HP:0000713)1.71914822
148Vitreoretinal degeneration (HP:0000655)1.71314530
149Abnormality of the periventricular white matter (HP:0002518)1.70986067
150Epileptiform EEG discharges (HP:0011182)1.70932917
151Abnormality of the calf musculature (HP:0001430)1.70902699
152Aplasia/Hypoplasia of the spleen (HP:0010451)1.70041611
153Impaired vibration sensation in the lower limbs (HP:0002166)1.69951154
154Abnormality of permanent molar morphology (HP:0011071)1.69852868
155Abnormality of the dental root (HP:0006486)1.69852868
156Taurodontia (HP:0000679)1.69852868
157Retinitis pigmentosa (HP:0000510)1.68800634
158Hyperlipoproteinemia (HP:0010980)1.66446362
159Asplenia (HP:0001746)1.65767427
160Tubulointerstitial nephritis (HP:0001970)1.65729348
161Spastic gait (HP:0002064)1.65319934
162True hermaphroditism (HP:0010459)1.64627489
163Lymphangioma (HP:0100764)1.63790458
164Bile duct proliferation (HP:0001408)1.62300805
165Abnormal biliary tract physiology (HP:0012439)1.62300805
166Peripheral hypomyelination (HP:0007182)1.61840234
167Renal salt wasting (HP:0000127)1.59447979
168Amelogenesis imperfecta (HP:0000705)1.58648478
169Germ cell neoplasia (HP:0100728)1.58319676
170Male infertility (HP:0003251)1.56218230
171Abnormality of the dental pulp (HP:0006479)1.51686743
172Broad alveolar ridges (HP:0000187)1.51083013
173Urinary bladder sphincter dysfunction (HP:0002839)1.50904269
174Labial hypoplasia (HP:0000066)1.50758366
175Metaphyseal cupping (HP:0003021)1.49194702
176Diaphragmatic weakness (HP:0009113)1.45230623
177Pancreatic fibrosis (HP:0100732)1.45024914
178Carpal bone hypoplasia (HP:0001498)1.43955094
179Hemorrhage of the eye (HP:0011885)1.43827987
180Hypercholesterolemia (HP:0003124)1.43389545
181Osteomalacia (HP:0002749)1.42306658
182Testicular neoplasm (HP:0010788)1.40805402
183Torticollis (HP:0000473)1.38474247
184Abnormality of molar (HP:0011077)1.37798324
185Abnormality of molar morphology (HP:0011070)1.37798324
186Restlessness (HP:0000711)1.36876547
187Neoplasm of the heart (HP:0100544)1.36250862
188Neurofibrillary tangles (HP:0002185)1.35510363
189Supranuclear gaze palsy (HP:0000605)1.33424764
190Status epilepticus (HP:0002133)1.32260751

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.33364934
2NTRK34.23625325
3EEF2K3.32416497
4TRIB33.28820818
5FGFR43.22968124
6MAP2K72.98518932
7PRKD32.93790500
8MAPK152.92690414
9EPHA42.90211742
10SMG12.86217432
11MAP3K42.79768279
12MAP3K122.62874155
13MARK12.60360971
14TNIK2.55464465
15FGFR22.19202413
16NTRK22.06334997
17ICK2.05452819
18MAPK132.03524633
19MINK11.99640932
20MAP3K91.89228225
21EPHA31.82949600
22GRK51.74000647
23MAP2K41.69974653
24SIK21.67589758
25MAPKAPK31.64237784
26CAMKK11.63733237
27PNCK1.60605814
28ERN11.59904082
29GRK71.57333972
30PHKG21.52280066
31PHKG11.52280066
32PLK21.50836981
33TYRO31.48018106
34CAMK1D1.47010725
35TAOK11.43460264
36MAP3K111.37569863
37LMTK21.36460274
38PKN21.34945266
39NME11.31176528
40EPHA21.30828269
41TNK21.29997817
42CDK191.29689251
43DYRK21.29339294
44MAP4K11.26659873
45FGFR31.24839222
46MUSK1.24776948
47CAMK2A1.23654529
48GRK11.22459736
49DAPK21.21956376
50SIK31.21786202
51CDK51.21058476
52DYRK1B1.20372179
53FES1.18092177
54RIPK11.16200215
55MAP3K131.15147294
56PRPF4B1.14493025
57RIPK41.14211400
58PRKD21.13232380
59PAK61.12268287
60CAMK11.10043312
61NTRK11.07817842
62UHMK11.06405821
63MARK21.05731955
64INSRR1.02330826
65SIK11.02031003
66CDK31.00847704
67PRKCZ1.00040640
68DYRK1A0.98012745
69SGK20.95861142
70PRKCE0.94963800
71ADRBK20.94493413
72RPS6KA20.93355947
73EPHB10.93249833
74PRKCG0.92976894
75DYRK30.92668876
76SGK4940.92588255
77SGK2230.92588255
78CAMK2B0.92312919
79FER0.89545519
80CAMK2D0.88703094
81ERBB20.87337518
82CAMK1G0.85982941
83HIPK20.85662725
84AKT30.85370233
85MAPKAPK50.84831829
86PTK60.84072260
87SGK30.84028850
88TIE10.83995765
89PTK2B0.83760769
90MYLK0.83355205
91KSR10.81935948
92IRAK20.80696519
93DAPK10.79900326
94ADRBK10.79697051
95GRK60.79226529
96OXSR10.78553612
97BMPR20.76512715
98PRKCI0.73422436
99PINK10.70416750
100PIK3CA0.70280411
101MAPK120.67808506
102PAK30.65426873
103SGK10.64758613
104ARAF0.64120818
105PDPK10.63365210
106FGR0.62912744
107BCR0.62442295
108CSNK1G20.61833604
109STK380.61689052
110PRKAA20.61304151
111ALK0.60065071
112BCKDK0.60064922
113MAP2K20.59275800
114PRKAA10.58228967
115PRKACA0.58062775
116CAMKK20.57283692
117STK110.56977393
118MAP3K70.55886322
119PDK10.55726828
120CDK180.55354075
121PKN10.55160637
122RET0.54811625
123NEK60.54802931
124CDC42BPA0.54120877
125CAMK40.52638980
126BMPR1B0.52519030
127MAP3K60.51024881
128CDK150.50457990
129PRKD10.49690847
130EPHB20.49572040
131DMPK0.49058918
132OBSCN0.47602718
133PRKG10.47273028
134MAP2K60.47044069
135CDK140.46364342
136PRKCH0.45665588
137WNK10.45505371
138YES10.45153056
139MAPK100.44716809
140CDK11A0.44389725
141MATK0.44207252
142WNK30.43012563
143CAMK2G0.42767410
144RPS6KA10.42030879
145FGFR10.41902985
146MTOR0.40667939
147MAPK80.39321195
148PRKCB0.39189478
149CSNK1A1L0.38929016
150CSNK1A10.38737015
151MAP2K10.38729894
152STK160.38447656
153TESK20.38090706
154RPS6KC10.35597730

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.46056859
2Phototransduction_Homo sapiens_hsa047443.35678490
3Histidine metabolism_Homo sapiens_hsa003403.25669003
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.97019551
5Synaptic vesicle cycle_Homo sapiens_hsa047212.89248707
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.75728709
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.62462269
8GABAergic synapse_Homo sapiens_hsa047272.62331290
9Circadian entrainment_Homo sapiens_hsa047132.59392292
10Morphine addiction_Homo sapiens_hsa050322.56586904
11Primary bile acid biosynthesis_Homo sapiens_hsa001202.42067994
12Glutamatergic synapse_Homo sapiens_hsa047242.39784046
13Olfactory transduction_Homo sapiens_hsa047402.35105354
14Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.25344902
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.21510234
16Taste transduction_Homo sapiens_hsa047422.20586262
17Tyrosine metabolism_Homo sapiens_hsa003502.19007668
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.16112496
19beta-Alanine metabolism_Homo sapiens_hsa004102.16088071
20Amphetamine addiction_Homo sapiens_hsa050312.13563772
21Serotonergic synapse_Homo sapiens_hsa047262.08860113
22Complement and coagulation cascades_Homo sapiens_hsa046102.06999477
23Long-term potentiation_Homo sapiens_hsa047201.98220106
24Salivary secretion_Homo sapiens_hsa049701.98003960
25Dopaminergic synapse_Homo sapiens_hsa047281.90393326
26Oxidative phosphorylation_Homo sapiens_hsa001901.83631191
27Renin secretion_Homo sapiens_hsa049241.82124429
28Chemical carcinogenesis_Homo sapiens_hsa052041.81694261
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.81505854
30Cardiac muscle contraction_Homo sapiens_hsa042601.81075038
31Cholinergic synapse_Homo sapiens_hsa047251.80254468
32Insulin secretion_Homo sapiens_hsa049111.78180934
33Collecting duct acid secretion_Homo sapiens_hsa049661.74099303
34Calcium signaling pathway_Homo sapiens_hsa040201.73314918
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.72989201
36Retinol metabolism_Homo sapiens_hsa008301.71129053
37Arginine biosynthesis_Homo sapiens_hsa002201.71014230
38Fatty acid degradation_Homo sapiens_hsa000711.68633960
39Linoleic acid metabolism_Homo sapiens_hsa005911.66883844
40Long-term depression_Homo sapiens_hsa047301.59104299
41Oxytocin signaling pathway_Homo sapiens_hsa049211.58211946
42Caffeine metabolism_Homo sapiens_hsa002321.57337136
43Cocaine addiction_Homo sapiens_hsa050301.56280107
44Aldosterone synthesis and secretion_Homo sapiens_hsa049251.54403479
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.52212608
46Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.51464455
47Gastric acid secretion_Homo sapiens_hsa049711.49314393
48Alzheimers disease_Homo sapiens_hsa050101.44720089
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.43985463
50Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.42081281
51Parkinsons disease_Homo sapiens_hsa050121.41613698
52Butanoate metabolism_Homo sapiens_hsa006501.41370327
53Steroid biosynthesis_Homo sapiens_hsa001001.40331808
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.35551717
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.33895426
56Arginine and proline metabolism_Homo sapiens_hsa003301.31728797
572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.28477572
58Bile secretion_Homo sapiens_hsa049761.27866531
59Fatty acid elongation_Homo sapiens_hsa000621.26133809
60GnRH signaling pathway_Homo sapiens_hsa049121.23045219
61Peroxisome_Homo sapiens_hsa041461.22644161
62cAMP signaling pathway_Homo sapiens_hsa040241.22150476
63ABC transporters_Homo sapiens_hsa020101.15248364
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.15212277
65Fatty acid metabolism_Homo sapiens_hsa012121.15024031
66Notch signaling pathway_Homo sapiens_hsa043301.14826996
67Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.14250007
68Dilated cardiomyopathy_Homo sapiens_hsa054141.13543175
69Axon guidance_Homo sapiens_hsa043601.11573683
70Vascular smooth muscle contraction_Homo sapiens_hsa042701.09262044
71Pentose and glucuronate interconversions_Homo sapiens_hsa000401.08057335
72Gap junction_Homo sapiens_hsa045401.07931765
73cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06284506
74PPAR signaling pathway_Homo sapiens_hsa033201.03842110
75Circadian rhythm_Homo sapiens_hsa047101.03632061
76Arachidonic acid metabolism_Homo sapiens_hsa005901.01332497
77Vibrio cholerae infection_Homo sapiens_hsa051101.01010193
78Steroid hormone biosynthesis_Homo sapiens_hsa001401.00607414
79Vitamin B6 metabolism_Homo sapiens_hsa007500.98059652
80Huntingtons disease_Homo sapiens_hsa050160.97986985
81Biosynthesis of amino acids_Homo sapiens_hsa012300.96929083
82Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.90050784
83Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.89474122
84Pancreatic secretion_Homo sapiens_hsa049720.88669448
85Fat digestion and absorption_Homo sapiens_hsa049750.88335608
86Vitamin digestion and absorption_Homo sapiens_hsa049770.88281956
87Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.87982760
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87292896
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86514936
90Staphylococcus aureus infection_Homo sapiens_hsa051500.86018752
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85717185
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83819131
93Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.83065465
94Ether lipid metabolism_Homo sapiens_hsa005650.81878461
95Melanogenesis_Homo sapiens_hsa049160.81570623
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80716996
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79215758
98Tryptophan metabolism_Homo sapiens_hsa003800.76046844
99Type II diabetes mellitus_Homo sapiens_hsa049300.75598408
100Lysine degradation_Homo sapiens_hsa003100.74304934
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70364900
102ErbB signaling pathway_Homo sapiens_hsa040120.69993526
103Glycosaminoglycan degradation_Homo sapiens_hsa005310.69654969
104Estrogen signaling pathway_Homo sapiens_hsa049150.69312463
105Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68362393
106* Sphingolipid metabolism_Homo sapiens_hsa006000.67360994
107Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66433901
108MAPK signaling pathway_Homo sapiens_hsa040100.63148837
109Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62487850
110Ovarian steroidogenesis_Homo sapiens_hsa049130.61023029
111AMPK signaling pathway_Homo sapiens_hsa041520.59149944
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.57780543
113Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55814157
114Tight junction_Homo sapiens_hsa045300.55336065
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54087586
116Cysteine and methionine metabolism_Homo sapiens_hsa002700.53675490
117Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.52877603
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52143286
119Ras signaling pathway_Homo sapiens_hsa040140.51667080
120Dorso-ventral axis formation_Homo sapiens_hsa043200.48730429
121African trypanosomiasis_Homo sapiens_hsa051430.47708159
122Rheumatoid arthritis_Homo sapiens_hsa053230.47506373
123Regulation of autophagy_Homo sapiens_hsa041400.46402231
124Choline metabolism in cancer_Homo sapiens_hsa052310.46241230
125Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45526895
126Glycerolipid metabolism_Homo sapiens_hsa005610.44630829
127Drug metabolism - other enzymes_Homo sapiens_hsa009830.42636422
128Glioma_Homo sapiens_hsa052140.42486323
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40496496
130Propanoate metabolism_Homo sapiens_hsa006400.40410199
131Insulin signaling pathway_Homo sapiens_hsa049100.40328772
132Carbon metabolism_Homo sapiens_hsa012000.40202485
133Wnt signaling pathway_Homo sapiens_hsa043100.39570036
134Rap1 signaling pathway_Homo sapiens_hsa040150.39499490
135Insulin resistance_Homo sapiens_hsa049310.38771183
136Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36521634
137SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36116428
138Thyroid hormone synthesis_Homo sapiens_hsa049180.36015999
139Glucagon signaling pathway_Homo sapiens_hsa049220.35877816
140Lysosome_Homo sapiens_hsa041420.35670777
141Fructose and mannose metabolism_Homo sapiens_hsa000510.35436688
142Inositol phosphate metabolism_Homo sapiens_hsa005620.35178811
143Other glycan degradation_Homo sapiens_hsa005110.34788782
144Starch and sucrose metabolism_Homo sapiens_hsa005000.34446266
145Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34403776
146Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34135484
147Alcoholism_Homo sapiens_hsa050340.33202941
148Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28841782
149Oocyte meiosis_Homo sapiens_hsa041140.27810774
150Melanoma_Homo sapiens_hsa052180.23512456
151Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23266780
152* Sphingolipid signaling pathway_Homo sapiens_hsa040710.21082870
153Phenylalanine metabolism_Homo sapiens_hsa003600.19000344
154Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.16381989
155Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.16319237
156Fatty acid biosynthesis_Homo sapiens_hsa000610.16064601
157VEGF signaling pathway_Homo sapiens_hsa043700.15918333
158Mineral absorption_Homo sapiens_hsa049780.15819817
159Neurotrophin signaling pathway_Homo sapiens_hsa047220.14740969
160Platelet activation_Homo sapiens_hsa046110.14401102
161Glycerophospholipid metabolism_Homo sapiens_hsa005640.14112024

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