CERS5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to the TLC (TRAM, LAG1 and CLN8 homology domains) family of proteins. The encoded protein functions in the synthesis of ceramide, a lipid molecule that is involved in a several cellular signaling pathways. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.23921478
2behavioral response to nicotine (GO:0035095)5.09923904
3axon ensheathment in central nervous system (GO:0032291)4.64665104
4central nervous system myelination (GO:0022010)4.64665104
5negative regulation of telomere maintenance (GO:0032205)4.39328526
6fucose catabolic process (GO:0019317)4.31981549
7L-fucose metabolic process (GO:0042354)4.31981549
8L-fucose catabolic process (GO:0042355)4.31981549
9DNA deamination (GO:0045006)4.26636999
10nucleobase catabolic process (GO:0046113)4.11432437
11response to pheromone (GO:0019236)4.07051958
12protein localization to cilium (GO:0061512)3.72908580
13gamma-aminobutyric acid transport (GO:0015812)3.64272705
14behavioral response to ethanol (GO:0048149)3.51921700
15histone H2B ubiquitination (GO:0033523)3.49040974
16detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.45072931
17G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.38449525
18regulation of telomere maintenance (GO:0032204)3.36905726
19NADH dehydrogenase complex assembly (GO:0010257)3.36432714
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.36432714
21mitochondrial respiratory chain complex I assembly (GO:0032981)3.36432714
22kynurenine metabolic process (GO:0070189)3.31423614
23protein complex biogenesis (GO:0070271)3.30364208
24nonmotile primary cilium assembly (GO:0035058)3.29550296
25ribosomal small subunit biogenesis (GO:0042274)3.25963083
26tryptophan catabolic process (GO:0006569)3.25714709
27indole-containing compound catabolic process (GO:0042436)3.25714709
28indolalkylamine catabolic process (GO:0046218)3.25714709
29protein-cofactor linkage (GO:0018065)3.24801349
30negative regulation of mast cell activation (GO:0033004)3.23270284
31water-soluble vitamin biosynthetic process (GO:0042364)3.22127463
32indolalkylamine metabolic process (GO:0006586)3.21533516
33detection of light stimulus involved in sensory perception (GO:0050962)3.20913097
34detection of light stimulus involved in visual perception (GO:0050908)3.20913097
35neural tube formation (GO:0001841)3.18485290
36myelination (GO:0042552)3.15350989
37ensheathment of neurons (GO:0007272)3.14512828
38axon ensheathment (GO:0008366)3.14512828
39platelet dense granule organization (GO:0060155)3.13645311
40negative regulation of synaptic transmission, GABAergic (GO:0032229)3.13332802
41DNA double-strand break processing (GO:0000729)3.11891352
42presynaptic membrane organization (GO:0097090)3.04810815
43presynaptic membrane assembly (GO:0097105)3.03668676
44mitochondrial respiratory chain complex assembly (GO:0033108)3.02873203
45cornea development in camera-type eye (GO:0061303)3.00511621
46maturation of SSU-rRNA (GO:0030490)2.99591994
47postsynaptic membrane organization (GO:0001941)2.98310269
48epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.97126644
49L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.96400089
50long-chain fatty acid biosynthetic process (GO:0042759)2.96242678
51regulation of cilium movement (GO:0003352)2.95217496
52viral transcription (GO:0019083)2.93999383
53preassembly of GPI anchor in ER membrane (GO:0016254)2.91933115
54negative regulation of transcription regulatory region DNA binding (GO:2000678)2.90911470
55synaptic transmission, cholinergic (GO:0007271)2.88714681
56respiratory chain complex IV assembly (GO:0008535)2.88044301
57ubiquinone metabolic process (GO:0006743)2.87090267
58translational termination (GO:0006415)2.86309256
59mannosylation (GO:0097502)2.82779332
60ubiquinone biosynthetic process (GO:0006744)2.79269590
61axoneme assembly (GO:0035082)2.79176895
62protein deneddylation (GO:0000338)2.77653671
63kidney morphogenesis (GO:0060993)2.76728859
64negative regulation of translation, ncRNA-mediated (GO:0040033)2.75855172
65regulation of translation, ncRNA-mediated (GO:0045974)2.75855172
66negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.75855172
67cullin deneddylation (GO:0010388)2.74411625
68cellular ketone body metabolic process (GO:0046950)2.74075363
69tryptophan metabolic process (GO:0006568)2.73842650
70intraciliary transport (GO:0042073)2.72044790
71retinal cone cell development (GO:0046549)2.71134941
72cotranslational protein targeting to membrane (GO:0006613)2.70101328
73amine catabolic process (GO:0009310)2.69216473
74cellular biogenic amine catabolic process (GO:0042402)2.69216473
75cytochrome complex assembly (GO:0017004)2.68555201
76positive regulation of oligodendrocyte differentiation (GO:0048714)2.68103922
77positive regulation of mitochondrial fission (GO:0090141)2.64673006
78neuronal action potential (GO:0019228)2.64352882
79epithelial cilium movement (GO:0003351)2.63393671
80transmission of nerve impulse (GO:0019226)2.62938204
81regulation of development, heterochronic (GO:0040034)2.62900172
82protein targeting to ER (GO:0045047)2.62383033
83photoreceptor cell development (GO:0042461)2.62105070
84pyrimidine dimer repair (GO:0006290)2.61090956
85regulation of timing of cell differentiation (GO:0048505)2.59813074
86SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.58911782
87C4-dicarboxylate transport (GO:0015740)2.58398201
88ketone body metabolic process (GO:1902224)2.58140915
89glycosphingolipid biosynthetic process (GO:0006688)2.57441158
90regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.56185133
91establishment of protein localization to endoplasmic reticulum (GO:0072599)2.56092729
92RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.55386137
93sulfation (GO:0051923)2.54136760
94regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.53785147
95cilium organization (GO:0044782)2.53115992
96inner ear receptor stereocilium organization (GO:0060122)2.52628426
97photoreceptor cell maintenance (GO:0045494)2.52246243
98glutamate receptor signaling pathway (GO:0007215)2.50016915
99amino acid salvage (GO:0043102)2.49103567
100L-methionine salvage (GO:0071267)2.49103567
101L-methionine biosynthetic process (GO:0071265)2.49103567
102S-adenosylmethionine metabolic process (GO:0046500)2.48756287
103protein localization to endoplasmic reticulum (GO:0070972)2.48517850
104glycerophospholipid catabolic process (GO:0046475)2.48435688
105fucosylation (GO:0036065)2.47983330
106cilium assembly (GO:0042384)2.47913681
107regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.47609786
108negative regulation of DNA-dependent DNA replication (GO:2000104)2.47164489
109regulation of action potential (GO:0098900)2.46923852
110proline transport (GO:0015824)2.44809029
111negative regulation of cytosolic calcium ion concentration (GO:0051481)2.43492284
112DNA unwinding involved in DNA replication (GO:0006268)2.43120530
113neuron cell-cell adhesion (GO:0007158)2.42971237
114regulation of rhodopsin mediated signaling pathway (GO:0022400)2.41457531
115magnesium ion transport (GO:0015693)2.41309233
116neuronal action potential propagation (GO:0019227)2.41164428
117vocalization behavior (GO:0071625)2.40959623
118translational initiation (GO:0006413)2.38042368
119sensory perception of smell (GO:0007608)2.37697236
120cellular protein complex disassembly (GO:0043624)2.36217228
121translational elongation (GO:0006414)2.31420550
122fatty acid elongation (GO:0030497)2.30516634
123viral life cycle (GO:0019058)2.29937523
124activated T cell proliferation (GO:0050798)2.29789833
125negative regulation of execution phase of apoptosis (GO:1900118)2.27828002
126cell fate commitment involved in formation of primary germ layer (GO:0060795)2.24154629
127nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.23387675
128negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.21031474
129nuclear envelope reassembly (GO:0031468)2.19228320
130mitotic nuclear envelope reassembly (GO:0007084)2.19228320
131limb bud formation (GO:0060174)2.18535403
132negative regulation of neurotransmitter secretion (GO:0046929)2.17467550
133establishment of integrated proviral latency (GO:0075713)2.14428453
134blastocyst development (GO:0001824)2.13875581
135mesodermal cell differentiation (GO:0048333)2.13138483
136protein polyglutamylation (GO:0018095)2.12106316
137positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.11269860
138microtubule polymerization or depolymerization (GO:0031109)2.11135284
139establishment of mitochondrion localization (GO:0051654)2.09329196
140protein complex disassembly (GO:0043241)2.08927979
141facial nerve structural organization (GO:0021612)2.08882910
1427-methylguanosine mRNA capping (GO:0006370)2.07383459
143microtubule severing (GO:0051013)2.07358738
144oligodendrocyte differentiation (GO:0048709)2.06973843
145regulation of exit from mitosis (GO:0007096)2.06107777
146spindle assembly involved in mitosis (GO:0090307)2.06099337
147ear development (GO:0043583)2.05595518
148ribosomal small subunit assembly (GO:0000028)2.03255444
149establishment of protein localization to mitochondrial membrane (GO:0090151)2.02202915
150ribosomal large subunit biogenesis (GO:0042273)2.02003888
151myelin maintenance (GO:0043217)2.01973405
152regulation of oligodendrocyte differentiation (GO:0048713)2.01666013
153positive regulation of DNA-templated transcription, elongation (GO:0032786)2.01253562
154protein neddylation (GO:0045116)2.00766196
1557-methylguanosine RNA capping (GO:0009452)2.00104352
156RNA capping (GO:0036260)2.00104352
157negative regulation of neurotransmitter transport (GO:0051589)1.99518614
158positive regulation of glial cell differentiation (GO:0045687)1.99191153
159regulation of phospholipid biosynthetic process (GO:0071071)1.98994351
160regulation of collateral sprouting (GO:0048670)1.98156750
161protein targeting to membrane (GO:0006612)1.97182729
162dermatan sulfate biosynthetic process (GO:0030208)1.97122298
163establishment of viral latency (GO:0019043)1.96675995
164astrocyte development (GO:0014002)1.96218355
165regulation of female gonad development (GO:2000194)1.95044486
166nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)1.92979925
167macromolecular complex disassembly (GO:0032984)1.92871095
168exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 1.92602755
169dermatan sulfate metabolic process (GO:0030205)1.92086404
170negative regulation of axon extension involved in axon guidance (GO:0048843)1.91993046
171protein palmitoylation (GO:0018345)1.89260557
172negative regulation of axon guidance (GO:1902668)1.88537554
173enteric nervous system development (GO:0048484)1.86672974
174positive regulation of gliogenesis (GO:0014015)1.85625508
175negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)1.84126943
176negative regulation of ligase activity (GO:0051352)1.83988432
177negative regulation of ubiquitin-protein transferase activity (GO:0051444)1.83988432
178positive regulation of actin filament depolymerization (GO:0030836)1.80633746
179regulation of transcription elongation from RNA polymerase II promoter (GO:0034243)1.78812735
180proteasome assembly (GO:0043248)1.78795433
181neuron remodeling (GO:0016322)1.78399330
182cilium morphogenesis (GO:0060271)1.77658265
183substantia nigra development (GO:0021762)1.77564536
184anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:01.77301819
185DNA damage response, detection of DNA damage (GO:0042769)1.77293233
186histone monoubiquitination (GO:0010390)1.76917847
187regulation of homotypic cell-cell adhesion (GO:0034110)1.75173359
188wound healing, spreading of cells (GO:0044319)1.74655473
189nuclear-transcribed mRNA catabolic process (GO:0000956)1.74366074
190regulation of execution phase of apoptosis (GO:1900117)1.73437802
191transcription elongation from RNA polymerase III promoter (GO:0006385)1.72354480
192termination of RNA polymerase III transcription (GO:0006386)1.72354480
193gonadal mesoderm development (GO:0007506)1.72029749
194cortical actin cytoskeleton organization (GO:0030866)1.72009679
195glial cell development (GO:0021782)1.71858199
196leukocyte migration involved in inflammatory response (GO:0002523)1.71238153

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.76220337
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.33265210
3STAT6_21828071_ChIP-Seq_BEAS2B_Human3.51387263
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.31403837
5GBX2_23144817_ChIP-Seq_PC3_Human3.19921414
6VDR_22108803_ChIP-Seq_LS180_Human3.09570969
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.06668400
8E2F7_22180533_ChIP-Seq_HELA_Human2.95508070
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.78235249
10IGF1R_20145208_ChIP-Seq_DFB_Human2.74995720
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.51590285
12WT1_19549856_ChIP-ChIP_CCG9911_Human2.43813449
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.41864808
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.29379106
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.28393659
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.28278981
17EZH2_22144423_ChIP-Seq_EOC_Human2.28085161
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.27390604
19MYC_18555785_ChIP-Seq_MESCs_Mouse2.25990181
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.25967161
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.25435800
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.23239467
23CTBP1_25329375_ChIP-Seq_LNCAP_Human2.10580663
24FLI1_27457419_Chip-Seq_LIVER_Mouse2.10377796
25P300_19829295_ChIP-Seq_ESCs_Human2.01034558
26ETS1_20019798_ChIP-Seq_JURKAT_Human1.91687550
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.86572538
28IRF1_19129219_ChIP-ChIP_H3396_Human1.86143265
29MYC_19079543_ChIP-ChIP_MESCs_Mouse1.82865233
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79820987
31CREB1_15753290_ChIP-ChIP_HEK293T_Human1.78309382
32POU5F1_16153702_ChIP-ChIP_HESCs_Human1.75767523
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.72262458
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68491557
35MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.67862035
36E2F4_17652178_ChIP-ChIP_JURKAT_Human1.67540527
37TP53_22573176_ChIP-Seq_HFKS_Human1.66863175
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63135374
39REST_21632747_ChIP-Seq_MESCs_Mouse1.62757691
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.60180104
41HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.58910599
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.58498761
43ELK1_22589737_ChIP-Seq_MCF10A_Human1.58465170
44XRN2_22483619_ChIP-Seq_HELA_Human1.57280895
45ELK1_19687146_ChIP-ChIP_HELA_Human1.55418132
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.53969284
47JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.52151503
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51008487
49TRIM28_21343339_ChIP-Seq_HEK293_Human1.50129409
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.48767160
51TTF2_22483619_ChIP-Seq_HELA_Human1.45759741
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45661142
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.45477080
54AR_25329375_ChIP-Seq_VCAP_Human1.45361234
55IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41935059
56CBP_20019798_ChIP-Seq_JUKART_Human1.41935059
57AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39623373
58FOXM1_23109430_ChIP-Seq_U2OS_Human1.38318889
59E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.38278654
60NELFA_20434984_ChIP-Seq_ESCs_Mouse1.37451360
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.37115588
62BCAT_22108803_ChIP-Seq_LS180_Human1.37048467
63PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36895260
64STAT3_23295773_ChIP-Seq_U87_Human1.35708889
65VDR_23849224_ChIP-Seq_CD4+_Human1.34523881
66MYC_19030024_ChIP-ChIP_MESCs_Mouse1.34518792
67FUS_26573619_Chip-Seq_HEK293_Human1.34004392
68SMAD4_21799915_ChIP-Seq_A2780_Human1.32408543
69DCP1A_22483619_ChIP-Seq_HELA_Human1.30824311
70TP63_19390658_ChIP-ChIP_HaCaT_Human1.30635195
71SOX2_19829295_ChIP-Seq_ESCs_Human1.30181599
72NANOG_19829295_ChIP-Seq_ESCs_Human1.30181599
73FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.28372363
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28047904
75TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27829830
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27829830
77KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.27468866
78KLF5_20875108_ChIP-Seq_MESCs_Mouse1.27418649
79MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.27410833
80TCF4_23295773_ChIP-Seq_U87_Human1.27276975
81ETV2_25802403_ChIP-Seq_MESCs_Mouse1.27058332
82AR_21909140_ChIP-Seq_LNCAP_Human1.26919231
83GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26870158
84FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.25791401
85MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.25253605
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25233668
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24982017
88HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.24266413
89PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24221929
90SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23486785
91DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.23448373
92SMAD3_21741376_ChIP-Seq_EPCs_Human1.22792492
93TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22354187
94TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21968851
95SMAD_19615063_ChIP-ChIP_OVARY_Human1.20653712
96REST_18959480_ChIP-ChIP_MESCs_Mouse1.18978178
97SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18596823
98RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.17478003
99TCF4_22108803_ChIP-Seq_LS180_Human1.16971799
100OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16630897
101SOX2_16153702_ChIP-ChIP_HESCs_Human1.16456089
102RUNX2_22187159_ChIP-Seq_PCA_Human1.16321033
103MYC_18358816_ChIP-ChIP_MESCs_Mouse1.16151335
104NCOR_22424771_ChIP-Seq_293T_Human1.13712742
105ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11875693
106NFE2_27457419_Chip-Seq_LIVER_Mouse1.10530542
107SRF_21415370_ChIP-Seq_HL-1_Mouse1.09538402
108EZH2_27294783_Chip-Seq_NPCs_Mouse1.09074063
109FLI1_21867929_ChIP-Seq_TH2_Mouse1.08616671
110GATA3_21878914_ChIP-Seq_MCF-7_Human1.08116426
111FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07921891
112FOXA1_25329375_ChIP-Seq_VCAP_Human1.07921891
113FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.07921227
114SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.07749024
115EWS_26573619_Chip-Seq_HEK293_Human1.06880499
116RNF2_27304074_Chip-Seq_NSC_Mouse1.06614148
117EZH2_27304074_Chip-Seq_ESCs_Mouse1.06254022
118SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.04907871
119FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04304406
120EOMES_21245162_ChIP-Seq_HESCs_Human1.03750701
121PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.03417284
122E2F1_18555785_ChIP-Seq_MESCs_Mouse1.02335554
123CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02300024
124SMAD4_21741376_ChIP-Seq_EPCs_Human1.02067858
125PRDM14_20953172_ChIP-Seq_ESCs_Human1.01007830
126AR_20517297_ChIP-Seq_VCAP_Human0.99723648
127MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.99554847
128GABP_19822575_ChIP-Seq_HepG2_Human0.99403040
129BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98682913
130SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.97478787
131HOXB7_26014856_ChIP-Seq_BT474_Human0.97064660
132NANOG_18555785_Chip-Seq_ESCs_Mouse0.96386065
133THAP11_20581084_ChIP-Seq_MESCs_Mouse0.96131400
134EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.96002195
135CRX_20693478_ChIP-Seq_RETINA_Mouse0.95894140
136CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.95603286
137FOXP3_21729870_ChIP-Seq_TREG_Human0.95481578
138FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95127449
139SOX17_20123909_ChIP-Seq_XEN_Mouse0.94860383
140EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93784703
141KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.93070737
142YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92732613
143TAF15_26573619_Chip-Seq_HEK293_Human0.92593119
144HOXB4_20404135_ChIP-ChIP_EML_Mouse0.90049486
145CBX2_27304074_Chip-Seq_ESCs_Mouse0.90021284
146CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.89614176
147TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.89572223
148CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89519280
149CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.89509868
150TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.89416241
151EED_16625203_ChIP-ChIP_MESCs_Mouse0.88298104
152E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.87238594
153MYCN_18555785_ChIP-Seq_MESCs_Mouse0.86369750
154CIITA_25753668_ChIP-Seq_RAJI_Human0.85165935
155EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.81541680
156TFEB_21752829_ChIP-Seq_HELA_Human0.81452560
157JARID2_20064375_ChIP-Seq_MESCs_Mouse0.80222344
158POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.79289903
159TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.78199052
160KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.77575161
161DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.76779463
162MYC_18940864_ChIP-ChIP_HL60_Human0.76450034
163NANOG_16153702_ChIP-ChIP_HESCs_Human0.76225677
164CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.74809360
165CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.74465497
166ZFX_18555785_ChIP-Seq_MESCs_Mouse0.74413329
167NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.73754791
168SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.73654245
169SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.73506848
170SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.72362662
171WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.71828690
172EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.71651079
173RNF2_18974828_ChIP-Seq_MESCs_Mouse0.71587328
174EZH2_18974828_ChIP-Seq_MESCs_Mouse0.71587328
175ER_23166858_ChIP-Seq_MCF-7_Human0.70404119
176CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.70342782

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001968_abnormal_touch/_nociception2.82950149
2MP0008438_abnormal_cutaneous_collagen2.72008230
3MP0002736_abnormal_nociception_after2.65151366
4MP0008877_abnormal_DNA_methylation2.44972692
5MP0006292_abnormal_olfactory_placode2.38717357
6MP0003195_calcinosis2.31270798
7MP0005551_abnormal_eye_electrophysiolog2.28393078
8MP0000569_abnormal_digit_pigmentation2.23893510
9MP0005623_abnormal_meninges_morphology2.21592141
10MP0001986_abnormal_taste_sensitivity2.21309391
11MP0009046_muscle_twitch2.21288727
12MP0009745_abnormal_behavioral_response2.15677755
13MP0002653_abnormal_ependyma_morphology2.09172379
14MP0004133_heterotaxia1.92278296
15MP0003787_abnormal_imprinting1.88268918
16MP0005253_abnormal_eye_physiology1.84688810
17MP0002272_abnormal_nervous_system1.84595644
18MP0004272_abnormal_basement_membrane1.82823477
19MP0000920_abnormal_myelination1.81078505
20MP0004142_abnormal_muscle_tone1.75367596
21MP0009379_abnormal_foot_pigmentation1.73723995
22MP0004885_abnormal_endolymph1.72377435
23MP0003315_abnormal_perineum_morphology1.71062238
24MP0003635_abnormal_synaptic_transmissio1.67034204
25MP0004742_abnormal_vestibular_system1.65594787
26MP0005084_abnormal_gallbladder_morpholo1.64671266
27MP0001486_abnormal_startle_reflex1.64523728
28MP0001501_abnormal_sleep_pattern1.63407026
29MP0003937_abnormal_limbs/digits/tail_de1.61366089
30MP0002735_abnormal_chemical_nociception1.59667994
31MP0008057_abnormal_DNA_replication1.57662500
32MP0002572_abnormal_emotion/affect_behav1.56218050
33MP0001958_emphysema1.54920936
34MP0000372_irregular_coat_pigmentation1.54847014
35MP0008872_abnormal_physiological_respon1.53560188
36MP0002557_abnormal_social/conspecific_i1.49599621
37MP0003950_abnormal_plasma_membrane1.49112673
38MP0002064_seizures1.48587763
39MP0004043_abnormal_pH_regulation1.47998146
40MP0002876_abnormal_thyroid_physiology1.47846855
41MP0010030_abnormal_orbit_morphology1.47608502
42MP0002063_abnormal_learning/memory/cond1.44536435
43MP0003693_abnormal_embryo_hatching1.42339192
44MP0008932_abnormal_embryonic_tissue1.41742643
45MP0001970_abnormal_pain_threshold1.40482124
46MP0000778_abnormal_nervous_system1.39917292
47MP0001299_abnormal_eye_distance/1.39815044
48MP0000427_abnormal_hair_cycle1.39445259
49MP0005171_absent_coat_pigmentation1.39162568
50MP0008058_abnormal_DNA_repair1.38727670
51MP0002638_abnormal_pupillary_reflex1.35282309
52MP0002102_abnormal_ear_morphology1.35222318
53MP0009250_abnormal_appendicular_skeleto1.34999776
54MP0002733_abnormal_thermal_nociception1.34214778
55MP0002067_abnormal_sensory_capabilities1.33667173
56MP0005394_taste/olfaction_phenotype1.33376226
57MP0005499_abnormal_olfactory_system1.33376226
58MP0004924_abnormal_behavior1.30856586
59MP0005386_behavior/neurological_phenoty1.30856586
60MP0001727_abnormal_embryo_implantation1.30795057
61MP0005503_abnormal_tendon_morphology1.28557446
62MP0005646_abnormal_pituitary_gland1.28168963
63MP0004957_abnormal_blastocyst_morpholog1.26212146
64MP0003011_delayed_dark_adaptation1.25839697
65MP0005409_darkened_coat_color1.25279765
66MP0001529_abnormal_vocalization1.25035047
67MP0004147_increased_porphyrin_level1.24416141
68MP0003385_abnormal_body_wall1.23831079
69MP0005645_abnormal_hypothalamus_physiol1.23388855
70MP0003122_maternal_imprinting1.23364907
71MP0008875_abnormal_xenobiotic_pharmacok1.22134216
72MP0002837_dystrophic_cardiac_calcinosis1.21727243
73MP0001984_abnormal_olfaction1.20101745
74MP0004859_abnormal_synaptic_plasticity1.19432904
75MP0002734_abnormal_mechanical_nocicepti1.17678655
76MP0005423_abnormal_somatic_nervous1.15789495
77MP0000049_abnormal_middle_ear1.14174793
78MP0004134_abnormal_chest_morphology1.13062124
79MP0009384_cardiac_valve_regurgitation1.11461262
80MP0000428_abnormal_craniofacial_morphol1.11433156
81MP0002095_abnormal_skin_pigmentation1.10220661
82MP0003136_yellow_coat_color1.09584455
83MP0003119_abnormal_digestive_system1.09484727
84MP0005195_abnormal_posterior_eye1.08541192
85MP0003091_abnormal_cell_migration1.07304361
86MP0003634_abnormal_glial_cell1.07153813
87MP0002938_white_spotting1.07089955
88MP0000955_abnormal_spinal_cord1.05804111
89MP0002822_catalepsy1.04696047
90MP0000537_abnormal_urethra_morphology1.04148608
91MP0003755_abnormal_palate_morphology1.03971858
92MP0003646_muscle_fatigue1.03747207
93MP0010386_abnormal_urinary_bladder1.03466076
94MP0002177_abnormal_outer_ear1.03123441
95MP0008789_abnormal_olfactory_epithelium1.02944043
96MP0009333_abnormal_splenocyte_physiolog1.02245766
97MP0002234_abnormal_pharynx_morphology1.01845663
98MP0005508_abnormal_skeleton_morphology1.01157491
99MP0003077_abnormal_cell_cycle1.01125728
100MP0000026_abnormal_inner_ear1.00834901
101MP0002295_abnormal_pulmonary_circulatio1.00529804
102MP0001293_anophthalmia0.99788392
103MP0001905_abnormal_dopamine_level0.99288983
104MP0003880_abnormal_central_pattern0.98635027
105MP0000465_gastrointestinal_hemorrhage0.98074548
106MP0001324_abnormal_eye_pigmentation0.97433970
107MP0002233_abnormal_nose_morphology0.97326074
108MP0003938_abnormal_ear_development0.96029393
109MP0002751_abnormal_autonomic_nervous0.95121152
110MP0000762_abnormal_tongue_morphology0.92490385
111MP0001502_abnormal_circadian_rhythm0.91679828
112MP0002254_reproductive_system_inflammat0.91237205
113MP0005187_abnormal_penis_morphology0.90449813
114MP0008007_abnormal_cellular_replicative0.90118960
115MP0002229_neurodegeneration0.89416437
116MP0003279_aneurysm0.89045102
117MP0000383_abnormal_hair_follicle0.89002064
118MP0001919_abnormal_reproductive_system0.88624801
119MP0001485_abnormal_pinna_reflex0.88379296
120MP0005367_renal/urinary_system_phenotyp0.87800320
121MP0000516_abnormal_urinary_system0.87800320
122MP0003935_abnormal_craniofacial_develop0.87501929
123MP0003137_abnormal_impulse_conducting0.87500080
124MP0003890_abnormal_embryonic-extraembry0.86666834
125MP0001188_hyperpigmentation0.86564268
126MP0002932_abnormal_joint_morphology0.86270840
127MP0002184_abnormal_innervation0.84383648
128MP0001730_embryonic_growth_arrest0.83977419
129MP0003861_abnormal_nervous_system0.83897631
130MP0005389_reproductive_system_phenotype0.82751970
131MP0006072_abnormal_retinal_apoptosis0.82300926
132MP0005257_abnormal_intraocular_pressure0.81958079
133MP0004811_abnormal_neuron_physiology0.81947700
134MP0003718_maternal_effect0.81936793
135MP0008260_abnormal_autophagy0.81838685
136MP0002928_abnormal_bile_duct0.80884796
137MP0002933_joint_inflammation0.79343073
138MP0001963_abnormal_hearing_physiology0.79248972
139MP0002085_abnormal_embryonic_tissue0.77780533
140MP0000432_abnormal_head_morphology0.77701253
141MP0004270_analgesia0.77357516
142MP0001879_abnormal_lymphatic_vessel0.77286174
143MP0003121_genomic_imprinting0.75954819
144MP0001851_eye_inflammation0.75530500
145MP0003123_paternal_imprinting0.75178531
146MP0005275_abnormal_skin_tensile0.74027558
147MP0000733_abnormal_muscle_development0.73647072
148MP0002116_abnormal_craniofacial_bone0.73524649
149MP0000350_abnormal_cell_proliferation0.72942547
150MP0003942_abnormal_urinary_system0.72308226
151MP0002114_abnormal_axial_skeleton0.71654474
152MP0003567_abnormal_fetal_cardiomyocyte0.71277636
153MP0002752_abnormal_somatic_nervous0.70978052
154MP0000015_abnormal_ear_pigmentation0.70739188
155MP0000631_abnormal_neuroendocrine_gland0.70526798
156MP0002092_abnormal_eye_morphology0.69291649
157MP0002084_abnormal_developmental_patter0.68780907
158MP0003111_abnormal_nucleus_morphology0.68046488
159MP0000647_abnormal_sebaceous_gland0.67771403
160MP0002282_abnormal_trachea_morphology0.66478707
161MP0001697_abnormal_embryo_size0.63738084
162MP0002882_abnormal_neuron_morphology0.63471360
163MP0010678_abnormal_skin_adnexa0.63002437
164MP0001542_abnormal_bone_strength0.62934463
165MP0001340_abnormal_eyelid_morphology0.62013949
166MP0000462_abnormal_digestive_system0.60915020
167MP0003632_abnormal_nervous_system0.60816174
168MP0002210_abnormal_sex_determination0.60667463
169MP0000534_abnormal_ureter_morphology0.60550128
170MP0002249_abnormal_larynx_morphology0.60316311
171MP0005174_abnormal_tail_pigmentation0.59421506
172MP0006276_abnormal_autonomic_nervous0.58830317

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.59449240
2Pancreatic fibrosis (HP:0100732)3.86837202
3True hermaphroditism (HP:0010459)3.86346220
4Premature rupture of membranes (HP:0001788)3.84539586
5Congenital stationary night blindness (HP:0007642)3.63230685
6Nephronophthisis (HP:0000090)3.62558077
7Progressive inability to walk (HP:0002505)3.24989849
8Medial flaring of the eyebrow (HP:0010747)3.21024882
9Degeneration of the lateral corticospinal tracts (HP:0002314)3.07654458
10Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.07654458
11Abnormality of the renal medulla (HP:0100957)3.07281039
12Inability to walk (HP:0002540)3.06576166
13Lissencephaly (HP:0001339)3.01883001
14Hyperventilation (HP:0002883)2.96616985
15Parakeratosis (HP:0001036)2.90443363
16Gait imbalance (HP:0002141)2.84305396
17Abnormality of the renal cortex (HP:0011035)2.77508176
18Retinal dysplasia (HP:0007973)2.73404607
19Cerebellar dysplasia (HP:0007033)2.68487530
20Hypoplastic pelvis (HP:0008839)2.67588207
21Cerebral hypomyelination (HP:0006808)2.65337709
22Congenital primary aphakia (HP:0007707)2.64993567
23Abolished electroretinogram (ERG) (HP:0000550)2.63519547
24Cystic liver disease (HP:0006706)2.63094350
25Nephrogenic diabetes insipidus (HP:0009806)2.60260978
26Abnormal drinking behavior (HP:0030082)2.59099841
27Polydipsia (HP:0001959)2.59099841
28Aplasia/Hypoplasia of the tibia (HP:0005772)2.55621351
29Tubular atrophy (HP:0000092)2.55541253
30Pendular nystagmus (HP:0012043)2.54044102
31Attenuation of retinal blood vessels (HP:0007843)2.52365596
32Broad distal phalanx of finger (HP:0009836)2.42581156
33Sclerocornea (HP:0000647)2.40410962
34Abnormality of the labia minora (HP:0012880)2.36791615
35Peripheral hypomyelination (HP:0007182)2.31637669
36Abnormality of dentin (HP:0010299)2.28877184
37Severe muscular hypotonia (HP:0006829)2.28660850
38Pachygyria (HP:0001302)2.28160192
39Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.27674055
40Soft skin (HP:0000977)2.26503289
41Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.24570200
42Abnormality of alanine metabolism (HP:0010916)2.24570200
43Hyperalaninemia (HP:0003348)2.24570200
44Increased corneal curvature (HP:0100692)2.23165852
45Keratoconus (HP:0000563)2.23165852
46Adrenal hypoplasia (HP:0000835)2.22040061
47Acute necrotizing encephalopathy (HP:0006965)2.21098308
48Hemiparesis (HP:0001269)2.20999019
49Vaginal atresia (HP:0000148)2.19752224
50Aplasia/Hypoplasia of the tongue (HP:0010295)2.19552127
51Genital tract atresia (HP:0001827)2.19504812
52Broad-based gait (HP:0002136)2.19484406
53Sensory axonal neuropathy (HP:0003390)2.19019226
54Polyphagia (HP:0002591)2.17965228
55Abnormal biliary tract physiology (HP:0012439)2.17942572
56Bile duct proliferation (HP:0001408)2.17942572
57Aplasia/Hypoplasia of the patella (HP:0006498)2.16872301
58Mitochondrial inheritance (HP:0001427)2.15980451
59Patellar aplasia (HP:0006443)2.15811201
60Short tibia (HP:0005736)2.15528238
61Congenital hepatic fibrosis (HP:0002612)2.14527853
62Autoamputation (HP:0001218)2.11776578
63Increased CSF lactate (HP:0002490)2.11536395
64Decreased central vision (HP:0007663)2.11320976
65Absent speech (HP:0001344)2.11066196
66Protrusio acetabuli (HP:0003179)2.10527226
67Short nail (HP:0001799)2.07769980
68Chronic hepatic failure (HP:0100626)2.06989465
69Adactyly (HP:0009776)2.05825346
703-Methylglutaconic aciduria (HP:0003535)2.04421114
71Polyuria (HP:0000103)2.03871975
72Esophageal atresia (HP:0002032)2.03583741
73Occipital encephalocele (HP:0002085)2.02635128
74Decreased electroretinogram (ERG) amplitude (HP:0000654)2.01948485
75Febrile seizures (HP:0002373)2.01716809
76Postaxial foot polydactyly (HP:0001830)1.97432584
77Acute encephalopathy (HP:0006846)1.97162837
78Gaze-evoked nystagmus (HP:0000640)1.97020663
79Focal seizures (HP:0007359)1.96325523
80Hypoplasia of the pons (HP:0012110)1.96262840
81Progressive cerebellar ataxia (HP:0002073)1.95378391
82Intestinal atresia (HP:0011100)1.94891767
83Optic nerve hypoplasia (HP:0000609)1.94670785
84Shallow orbits (HP:0000586)1.93303015
85Anteriorly placed anus (HP:0001545)1.92855869
86Aplasia/Hypoplasia of the sacrum (HP:0008517)1.92708007
87Postaxial hand polydactyly (HP:0001162)1.92702776
88Hypoplasia of the iris (HP:0007676)1.92541746
89Abnormality of the pons (HP:0007361)1.91361900
90Progressive macrocephaly (HP:0004481)1.91194029
91Abnormality of the ileum (HP:0001549)1.90155232
92Methylmalonic aciduria (HP:0012120)1.89826147
93Neurofibrillary tangles (HP:0002185)1.89087278
94Focal motor seizures (HP:0011153)1.88588557
95Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.87699260
96Abnormal rod and cone electroretinograms (HP:0008323)1.87304403
97Wormian bones (HP:0002645)1.87181405
98Methylmalonic acidemia (HP:0002912)1.86952486
99Large for gestational age (HP:0001520)1.86770125
100Hepatocellular necrosis (HP:0001404)1.86439067
101Asplenia (HP:0001746)1.85035319
102Furrowed tongue (HP:0000221)1.82686742
103Meckel diverticulum (HP:0002245)1.82411574
104Aplasia/Hypoplasia of the spleen (HP:0010451)1.82052157
105Abnormal mitochondria in muscle tissue (HP:0008316)1.81015205
106Dandy-Walker malformation (HP:0001305)1.80823821
107Abnormality of the umbilical cord (HP:0010881)1.80567949
108Chorioretinal atrophy (HP:0000533)1.80091752
109Optic disc pallor (HP:0000543)1.79594696
110Tachypnea (HP:0002789)1.79317449
111Hypoplasia of the capital femoral epiphysis (HP:0003090)1.78802632
112Renal cortical cysts (HP:0000803)1.78198922
113Progressive microcephaly (HP:0000253)1.78159453
114Preaxial hand polydactyly (HP:0001177)1.77741184
115Aplasia/Hypoplasia of the uvula (HP:0010293)1.77614992
116Aortic dissection (HP:0002647)1.76206238
117Fibular aplasia (HP:0002990)1.75886444
118Astigmatism (HP:0000483)1.75295735
119CNS hypomyelination (HP:0003429)1.75011218
120Small epiphyses (HP:0010585)1.74601238
121Vascular tortuosity (HP:0004948)1.74496565
122Broad ribs (HP:0000885)1.74030101
123Limb dystonia (HP:0002451)1.73251247
124Wrist flexion contracture (HP:0001239)1.72042744
125Myelomeningocele (HP:0002475)1.71479559
126Molar tooth sign on MRI (HP:0002419)1.71034300
127Abnormality of midbrain morphology (HP:0002418)1.71034300
128Buphthalmos (HP:0000557)1.70561983
129Abnormality of the corticospinal tract (HP:0002492)1.70557945
130Short clavicles (HP:0000894)1.70271996
131Arterial tortuosity (HP:0005116)1.70187735
132Narrow forehead (HP:0000341)1.70093504
133Insidious onset (HP:0003587)1.69204028
134Termporal pattern (HP:0011008)1.69204028
135Specific learning disability (HP:0001328)1.67763708
136Aganglionic megacolon (HP:0002251)1.67144320
137Abnormality of the phalanges of the 2nd finger (HP:0009541)1.66951913
138Reticulocytopenia (HP:0001896)1.64991692
139Anencephaly (HP:0002323)1.64670175
140Cervical subluxation (HP:0003308)1.64556968
141Abnormality of the 2nd finger (HP:0004100)1.64043114
142Glossoptosis (HP:0000162)1.62389549
143Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.60783981
144Absent epiphyses (HP:0010577)1.60783981
145Broad face (HP:0000283)1.60777677
146Aplasia/Hypoplasia of the clavicles (HP:0006710)1.60580181
147Osteolytic defects of the hand bones (HP:0009699)1.59064115
148Osteolytic defects of the phalanges of the hand (HP:0009771)1.59064115
149Postnatal microcephaly (HP:0005484)1.58589529
150Facial hemangioma (HP:0000329)1.57356936
151Stenosis of the external auditory canal (HP:0000402)1.57279802
152Abnormality of the calcaneus (HP:0008364)1.56106735
153Split foot (HP:0001839)1.55900034
154Intellectual disability, moderate (HP:0002342)1.54082900
155Abnormal auditory evoked potentials (HP:0006958)1.53229986
156Delayed cranial suture closure (HP:0000270)1.51269669
157Elbow flexion contracture (HP:0002987)1.50994472
158Scapular winging (HP:0003691)1.49987048
159Alacrima (HP:0000522)1.48990167
160Abnormal umbilical cord blood vessels (HP:0011403)1.47952468
161Single umbilical artery (HP:0001195)1.47952468
162Abnormality of the fetal cardiovascular system (HP:0010948)1.47952468
163Persistence of primary teeth (HP:0006335)1.45774735
164Decreased lacrimation (HP:0000633)1.44842910
16511 pairs of ribs (HP:0000878)1.44491889
166Congenital glaucoma (HP:0001087)1.44165373
167Ankle contracture (HP:0006466)1.42706369
168Atelectasis (HP:0100750)1.42579893
169Breast hypoplasia (HP:0003187)1.42133612
170Stridor (HP:0010307)1.41196130
171Calcaneovalgus deformity (HP:0001848)1.40983370
172Bladder diverticulum (HP:0000015)1.40184974
173Prominent occiput (HP:0000269)1.40131243
174Colon cancer (HP:0003003)1.39654103
175Microglossia (HP:0000171)1.39642200
176Concave nail (HP:0001598)1.37714641
177Epiphyseal dysplasia (HP:0002656)1.37533322
178Flared iliac wings (HP:0002869)1.36872023
179Infantile muscular hypotonia (HP:0008947)1.36355815
180Mitral regurgitation (HP:0001653)1.36169735
181Type II lissencephaly (HP:0007260)1.35756550
182Abnormality of the odontoid process (HP:0003310)1.34421113
183Segmental peripheral demyelination/remyelination (HP:0003481)1.33368630
184Pterygium (HP:0001059)1.33207613
185Hypoplasia of the odontoid process (HP:0003311)1.32406853
186Patchy hypopigmentation of hair (HP:0011365)1.31759325
187Deformed tarsal bones (HP:0008119)1.31283122
188Secondary amenorrhea (HP:0000869)1.30511200
189Dilatation of the ascending aorta (HP:0005111)1.30474633
190Chin dimple (HP:0010751)1.30420958
191Abnormality of the proximal phalanges of the hand (HP:0009834)1.30196087
192Meningocele (HP:0002435)1.29886720

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.37460997
2STK393.56308722
3ADRBK23.42579039
4BUB13.27490227
5TESK22.96843646
6WNK32.93479640
7PNCK2.72985469
8LIMK12.66182703
9MAPKAPK52.44131334
10MOS2.36122100
11TLK12.32108508
12TRIM282.31282405
13MAP4K22.31127491
14OXSR12.30124628
15PINK12.10546558
16NUAK12.10130039
17ZAK2.04138556
18MAP3K42.03622338
19CSNK1G32.03107218
20GRK12.01710190
21EPHB11.84604885
22CSNK1A1L1.73695280
23PASK1.72933016
24MKNK11.71902111
25ACVR1B1.71635422
26EPHA41.68181193
27TAOK31.65689928
28DYRK21.65507310
29BCKDK1.65044586
30CSNK1G11.64230917
31TNIK1.57494765
32CSNK1G21.50407108
33MAP2K71.50326562
34INSRR1.48673775
35DAPK21.48583406
36PLK41.45867659
37ARAF1.44563519
38BCR1.43895495
39STK101.42565904
40CDC71.42410492
41MST41.39488240
42MET1.39247384
43CDK191.38157317
44NME21.29733363
45CASK1.21147236
46UHMK11.19809848
47ADRBK11.19496739
48ROCK21.18456688
49WEE11.17586133
50PRKCG1.17119730
51NEK21.16738589
52FGR1.16068664
53NTRK31.13764099
54TXK1.10000094
55PAK11.09334664
56PRKCE1.07955333
57ERBB31.07793755
58VRK11.07251859
59MAPK131.07243287
60CLK11.05304079
61SRPK11.05274801
62AURKA1.03309418
63RPS6KA51.03071271
64WNK41.00466061
65TGFBR20.99924454
66TSSK60.98632072
67TRPM70.97818902
68MARK20.95593684
69PAK20.93046163
70PKN10.90647558
71STK38L0.89410187
72CDK140.89308620
73GRK70.88508943
74TYRO30.87547902
75PAK40.87065115
76TTN0.86869005
77KDR0.84294721
78PAK30.83352447
79BMPR1B0.83274174
80TESK10.81987027
81TGFBR10.81596159
82SIK20.81312986
83CAMKK20.80515146
84EPHA30.79927011
85LRRK20.77797006
86CAMK2B0.76828326
87DDR20.75459329
88CDK80.75407636
89PBK0.73134632
90ILK0.72894671
91MAP2K20.72774884
92PRKD20.72486613
93DYRK1A0.72378474
94FES0.70841281
95DYRK30.69189491
96PLK30.67831993
97MAPK150.66955425
98MINK10.65009295
99PDGFRB0.64860890
100PHKG20.64807932
101PHKG10.64807932
102CDK150.64679982
103MKNK20.63634631
104NEK60.63330527
105NTRK20.63141143
106NTRK10.62695772
107CAMK2A0.60169280
108CDK11A0.59641510
109PRKD30.59180726
110NLK0.58718016
111CDK180.58295185
112AURKB0.58137815
113CAMK2D0.57938310
114FER0.55557477
115PRKCQ0.55375261
116CCNB10.54997295
117MELK0.53942589
118FGFR20.53061824
119MUSK0.52757450
120INSR0.52257930
121PAK60.51556699
122MAP2K60.50671594
123PIK3CA0.50504252
124CSNK1D0.49937003
125BRSK20.49539421
126EEF2K0.48912127
127CSNK1A10.48419722
128FLT30.47620739
129HIPK20.47162492
130EPHB20.47063957
131PLK10.46464394
132MAP3K60.45492365
133CAMK1G0.44355877
134CHEK20.44051824
135PRKCZ0.43760252
136CDK30.43649943
137PTK2B0.43454946
138WNK10.43100696
139PRKCI0.42874098
140PRKACA0.42561472
141TIE10.41988416
142RPS6KA40.41808481
143PIM20.40845580
144MARK10.40805943
145CDK50.40583866
146ATR0.40573421
147LCK0.40160258
148YES10.40026729
149PLK20.39762266
150KIT0.39502426
151CAMK10.39081094
152SCYL20.36445446
153MARK30.35015512
154MAP2K40.33173425
155SIK30.30572258
156IKBKB0.30248093
157GRK50.30150875
158PRKCA0.28953609
159PRKACB0.26943079
160ABL10.26222163

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.86051031
2Nicotine addiction_Homo sapiens_hsa050332.77093575
3Phototransduction_Homo sapiens_hsa047442.72928574
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.68751776
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.50780769
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.49107257
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.43450399
8Butanoate metabolism_Homo sapiens_hsa006502.35177851
9Ribosome_Homo sapiens_hsa030102.28068759
10Selenocompound metabolism_Homo sapiens_hsa004502.22324802
11Linoleic acid metabolism_Homo sapiens_hsa005912.20975759
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.08869567
13Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.93703026
14RNA polymerase_Homo sapiens_hsa030201.88436820
15Collecting duct acid secretion_Homo sapiens_hsa049661.74230523
16Proteasome_Homo sapiens_hsa030501.74200525
17Nitrogen metabolism_Homo sapiens_hsa009101.73395577
18Protein export_Homo sapiens_hsa030601.72564613
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.70522627
20Spliceosome_Homo sapiens_hsa030401.60067498
21Taste transduction_Homo sapiens_hsa047421.57589473
22Morphine addiction_Homo sapiens_hsa050321.56689832
23GABAergic synapse_Homo sapiens_hsa047271.52206078
24Basal transcription factors_Homo sapiens_hsa030221.39271997
25Glutamatergic synapse_Homo sapiens_hsa047241.36314890
26Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.35432973
27Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.34877924
28Ether lipid metabolism_Homo sapiens_hsa005651.32492646
29Tryptophan metabolism_Homo sapiens_hsa003801.31798234
30* Sphingolipid metabolism_Homo sapiens_hsa006001.29240068
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.29226351
32DNA replication_Homo sapiens_hsa030301.29061928
33Cell cycle_Homo sapiens_hsa041101.28988856
34Nucleotide excision repair_Homo sapiens_hsa034201.26898458
35Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.26004217
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.25155115
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.24820254
38Propanoate metabolism_Homo sapiens_hsa006401.24188390
39Circadian entrainment_Homo sapiens_hsa047131.23040767
40Steroid biosynthesis_Homo sapiens_hsa001001.19098493
41Axon guidance_Homo sapiens_hsa043601.18869751
42Regulation of autophagy_Homo sapiens_hsa041401.18167222
43ECM-receptor interaction_Homo sapiens_hsa045121.17317141
44RNA transport_Homo sapiens_hsa030131.17106038
45Mismatch repair_Homo sapiens_hsa034301.14342673
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.13619857
47Homologous recombination_Homo sapiens_hsa034401.10852749
48Synaptic vesicle cycle_Homo sapiens_hsa047211.08052125
49Non-homologous end-joining_Homo sapiens_hsa034501.03228619
50Primary bile acid biosynthesis_Homo sapiens_hsa001201.02785522
51Vibrio cholerae infection_Homo sapiens_hsa051101.02457847
52RNA degradation_Homo sapiens_hsa030181.02376814
53Renal cell carcinoma_Homo sapiens_hsa052111.00379669
54Olfactory transduction_Homo sapiens_hsa047400.97358153
55Peroxisome_Homo sapiens_hsa041460.96044961
56Oxidative phosphorylation_Homo sapiens_hsa001900.92957066
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.92268596
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.91909415
59Oocyte meiosis_Homo sapiens_hsa041140.91235976
60Ovarian steroidogenesis_Homo sapiens_hsa049130.90948828
61MicroRNAs in cancer_Homo sapiens_hsa052060.90911199
62Hedgehog signaling pathway_Homo sapiens_hsa043400.90503887
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88875116
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.88626357
65Caffeine metabolism_Homo sapiens_hsa002320.88311602
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88140660
67Dopaminergic synapse_Homo sapiens_hsa047280.87486566
68Serotonergic synapse_Homo sapiens_hsa047260.86669068
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.86090439
70Insulin secretion_Homo sapiens_hsa049110.85664838
71Base excision repair_Homo sapiens_hsa034100.84116498
72Alcoholism_Homo sapiens_hsa050340.83964066
73Shigellosis_Homo sapiens_hsa051310.83306750
74Focal adhesion_Homo sapiens_hsa045100.82486089
75Cardiac muscle contraction_Homo sapiens_hsa042600.81434454
76Phagosome_Homo sapiens_hsa041450.79392637
77Parkinsons disease_Homo sapiens_hsa050120.79051978
78Gap junction_Homo sapiens_hsa045400.78907240
79One carbon pool by folate_Homo sapiens_hsa006700.78333922
80Arachidonic acid metabolism_Homo sapiens_hsa005900.78212301
81Hippo signaling pathway_Homo sapiens_hsa043900.78106045
82Tight junction_Homo sapiens_hsa045300.77530030
83TGF-beta signaling pathway_Homo sapiens_hsa043500.76072917
84p53 signaling pathway_Homo sapiens_hsa041150.75882889
85Colorectal cancer_Homo sapiens_hsa052100.75801124
86Cocaine addiction_Homo sapiens_hsa050300.74609735
87Epstein-Barr virus infection_Homo sapiens_hsa051690.73784562
88Fanconi anemia pathway_Homo sapiens_hsa034600.73611648
89Lysosome_Homo sapiens_hsa041420.73458500
90mRNA surveillance pathway_Homo sapiens_hsa030150.73378899
91beta-Alanine metabolism_Homo sapiens_hsa004100.72884739
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.72417343
93Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.72182503
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.71415887
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.71380330
96Other glycan degradation_Homo sapiens_hsa005110.71275152
97* Sphingolipid signaling pathway_Homo sapiens_hsa040710.70428797
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70184166
99N-Glycan biosynthesis_Homo sapiens_hsa005100.68835731
100ABC transporters_Homo sapiens_hsa020100.68173719
101Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67991608
102PI3K-Akt signaling pathway_Homo sapiens_hsa041510.66175379
103Rheumatoid arthritis_Homo sapiens_hsa053230.66129260
104Endocytosis_Homo sapiens_hsa041440.66075854
105Platelet activation_Homo sapiens_hsa046110.65362359
106Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64957011
107Wnt signaling pathway_Homo sapiens_hsa043100.63700420
108Long-term depression_Homo sapiens_hsa047300.63569090
109Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62649969
110Ras signaling pathway_Homo sapiens_hsa040140.62458948
111Intestinal immune network for IgA production_Homo sapiens_hsa046720.62254658
112Amphetamine addiction_Homo sapiens_hsa050310.62134483
113Basal cell carcinoma_Homo sapiens_hsa052170.61998469
114Purine metabolism_Homo sapiens_hsa002300.61287166
115Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.61051045
116Malaria_Homo sapiens_hsa051440.60195854
117Proteoglycans in cancer_Homo sapiens_hsa052050.60169814
118Viral carcinogenesis_Homo sapiens_hsa052030.60122899
119Alzheimers disease_Homo sapiens_hsa050100.60079762
120* Metabolic pathways_Homo sapiens_hsa011000.59651824
121Dorso-ventral axis formation_Homo sapiens_hsa043200.59303862
122Huntingtons disease_Homo sapiens_hsa050160.57845831
123Pathways in cancer_Homo sapiens_hsa052000.57212290
124Vascular smooth muscle contraction_Homo sapiens_hsa042700.57131753
125Pyrimidine metabolism_Homo sapiens_hsa002400.57127007
126Calcium signaling pathway_Homo sapiens_hsa040200.56839921
127GnRH signaling pathway_Homo sapiens_hsa049120.55220178
128Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54308117
129Viral myocarditis_Homo sapiens_hsa054160.54031345
130SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53989854
131Antigen processing and presentation_Homo sapiens_hsa046120.53363101
132AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53315889
133Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52903230
134Notch signaling pathway_Homo sapiens_hsa043300.52579786
135Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52574665
136Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52368410
137Salivary secretion_Homo sapiens_hsa049700.51553104
138Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51526274
139Small cell lung cancer_Homo sapiens_hsa052220.51475518
140Circadian rhythm_Homo sapiens_hsa047100.51373688
141HTLV-I infection_Homo sapiens_hsa051660.51368911
142Steroid hormone biosynthesis_Homo sapiens_hsa001400.51164538
143Phospholipase D signaling pathway_Homo sapiens_hsa040720.50214117
144Pancreatic cancer_Homo sapiens_hsa052120.49810367
145T cell receptor signaling pathway_Homo sapiens_hsa046600.49411364
146Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49322475
147Rap1 signaling pathway_Homo sapiens_hsa040150.49242542
148Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49228568
149Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49032347
150Adherens junction_Homo sapiens_hsa045200.48906366
151Fatty acid elongation_Homo sapiens_hsa000620.48130015
152Salmonella infection_Homo sapiens_hsa051320.47736532
153Chemical carcinogenesis_Homo sapiens_hsa052040.44486254
154Primary immunodeficiency_Homo sapiens_hsa053400.41667935
155Asthma_Homo sapiens_hsa053100.39496896
156Type I diabetes mellitus_Homo sapiens_hsa049400.39052935
157Fatty acid metabolism_Homo sapiens_hsa012120.37471949
158Glycerolipid metabolism_Homo sapiens_hsa005610.36094465
159Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35157524
160Cholinergic synapse_Homo sapiens_hsa047250.34462787
161Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33290266
162cAMP signaling pathway_Homo sapiens_hsa040240.31738403
163Fat digestion and absorption_Homo sapiens_hsa049750.31177565
164Cysteine and methionine metabolism_Homo sapiens_hsa002700.29476751
165Glycerophospholipid metabolism_Homo sapiens_hsa005640.27737170
166Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.27028975

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