CERS6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.32519023
2positive regulation by organism of defense response of other organism involved in symbiotic interact6.32519023
3modulation by symbiont of host immune response (GO:0052553)6.32519023
4positive regulation by symbiont of host defense response (GO:0052509)6.32519023
5modulation by symbiont of host defense response (GO:0052031)6.32519023
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.32519023
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.41805459
8response to peptidoglycan (GO:0032494)5.25726905
9neutrophil activation involved in immune response (GO:0002283)5.09661485
10macrophage activation involved in immune response (GO:0002281)4.81064220
11bundle of His cell to Purkinje myocyte communication (GO:0086069)4.76242195
12response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.55192482
13response to host immune response (GO:0052572)4.55192482
14desmosome organization (GO:0002934)4.52182584
15positive regulation of interferon-alpha production (GO:0032727)4.48522367
16regulation of interferon-alpha production (GO:0032647)4.22217109
17hydrogen peroxide biosynthetic process (GO:0050665)4.18796701
18positive regulation of cellular amide metabolic process (GO:0034250)4.14201148
19response to host (GO:0075136)4.08368131
20response to host defenses (GO:0052200)4.08368131
21response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.08368131
22regulation of interferon-beta biosynthetic process (GO:0045357)4.03692956
23immunoglobulin mediated immune response (GO:0016064)3.94185655
24respiratory burst (GO:0045730)3.89342262
25reactive oxygen species biosynthetic process (GO:1903409)3.88532480
26regulation of NFAT protein import into nucleus (GO:0051532)3.85385818
27positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.84987551
28cell communication involved in cardiac conduction (GO:0086065)3.79993290
29lipopolysaccharide-mediated signaling pathway (GO:0031663)3.76047729
30positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.75122796
31granulocyte activation (GO:0036230)3.73716088
32natural killer cell mediated cytotoxicity (GO:0042267)3.62973070
33natural killer cell mediated immunity (GO:0002228)3.62973070
34neutrophil activation (GO:0042119)3.62322272
35ventricular cardiac muscle cell action potential (GO:0086005)3.61946391
36positive regulation of chemokine biosynthetic process (GO:0045080)3.59919174
37superoxide anion generation (GO:0042554)3.59202228
38detection of molecule of bacterial origin (GO:0032490)3.59164868
39microglial cell activation (GO:0001774)3.52892783
40cellular response to interferon-alpha (GO:0035457)3.50049802
41response to muramyl dipeptide (GO:0032495)3.47995079
42layer formation in cerebral cortex (GO:0021819)3.37677786
43neutrophil mediated immunity (GO:0002446)3.35368595
44receptor recycling (GO:0001881)3.34260814
45intestinal epithelial cell development (GO:0060576)3.32382616
46regulation of dendritic cell antigen processing and presentation (GO:0002604)3.31321795
47positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.31033313
48positive regulation of mast cell activation involved in immune response (GO:0033008)3.29466338
49positive regulation of mast cell degranulation (GO:0043306)3.29466338
50production of molecular mediator involved in inflammatory response (GO:0002532)3.29412866
51I-kappaB phosphorylation (GO:0007252)3.29053999
52positive regulation of interferon-beta production (GO:0032728)3.27518616
53positive regulation of heat generation (GO:0031652)3.26848025
54cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.25433289
55response to interferon-alpha (GO:0035455)3.23367886
56type I interferon signaling pathway (GO:0060337)3.22630966
57cellular response to type I interferon (GO:0071357)3.22630966
58regulation of mononuclear cell migration (GO:0071675)3.22256341
59response to type I interferon (GO:0034340)3.19636877
60interferon-gamma-mediated signaling pathway (GO:0060333)3.17839682
61positive regulation of mast cell activation (GO:0033005)3.16348128
62embryonic retina morphogenesis in camera-type eye (GO:0060059)3.16193640
63apical protein localization (GO:0045176)3.15391135
64regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.15222705
65cytoskeletal anchoring at plasma membrane (GO:0007016)3.14707417
66macrophage activation (GO:0042116)3.14396280
67regulation of fever generation (GO:0031620)3.13544856
68negative regulation of neurotransmitter secretion (GO:0046929)3.13359348
69angiotensin maturation (GO:0002003)3.12678988
70negative regulation of dendrite morphogenesis (GO:0050774)3.12170670
71neuron recognition (GO:0008038)3.11275847
72myeloid cell activation involved in immune response (GO:0002275)3.11115176
73cell adhesion mediated by integrin (GO:0033627)3.10564931
74positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.10218137
75leukocyte mediated cytotoxicity (GO:0001909)3.09984425
76NIK/NF-kappaB signaling (GO:0038061)3.07573965
77G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.07062409
78hemidesmosome assembly (GO:0031581)3.05408034
79axonal fasciculation (GO:0007413)3.05169309
80cytoplasmic mRNA processing body assembly (GO:0033962)3.02105643
81positive regulation of type 2 immune response (GO:0002830)2.98818008
82negative regulation of viral genome replication (GO:0045071)2.97547638
83regulation of chemokine biosynthetic process (GO:0045073)2.96415524
84positive regulation of dendritic spine morphogenesis (GO:0061003)2.94806268
85regulation of bile acid biosynthetic process (GO:0070857)2.93020731
86regulation of T-helper 1 cell differentiation (GO:0045625)2.92742654
87positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.92230616
88B cell mediated immunity (GO:0019724)2.89651872
89cell communication by electrical coupling (GO:0010644)2.86787763
90positive regulation of leukocyte degranulation (GO:0043302)2.84708589
91positive regulation of interleukin-12 production (GO:0032735)2.84000213
92T-helper 1 type immune response (GO:0042088)2.82857749
93regulation of integrin activation (GO:0033623)2.81523070
94myeloid leukocyte mediated immunity (GO:0002444)2.81013073
95negative regulation of interleukin-12 production (GO:0032695)2.81001446
96cellular extravasation (GO:0045123)2.80370750
97leukocyte aggregation (GO:0070486)2.77944434
98positive regulation of antigen processing and presentation (GO:0002579)2.77302653
99regulation of mast cell degranulation (GO:0043304)2.76959866
100positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.76842044
101nerve growth factor signaling pathway (GO:0038180)2.75953078
102positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.74746792
103lymphocyte chemotaxis (GO:0048247)2.73785784
104regulation of interleukin-12 biosynthetic process (GO:0045075)2.72533740
105myeloid dendritic cell differentiation (GO:0043011)2.72457459
106mating behavior (GO:0007617)2.71382084
107detection of external biotic stimulus (GO:0098581)2.71170176
108positive regulation of natural killer cell differentiation (GO:0032825)2.69945181
109detection of other organism (GO:0098543)2.69907682
110negative regulation of interleukin-17 production (GO:0032700)2.69611290
111regulation of heart rate by cardiac conduction (GO:0086091)2.69363983
112endoplasmic reticulum organization (GO:0007029)2.69236339
113regulation of leukocyte degranulation (GO:0043300)2.67930851
114cardiac conduction (GO:0061337)2.67611773
115positive regulation of interleukin-6 production (GO:0032755)2.67297410
116positive regulation of glycoprotein biosynthetic process (GO:0010560)2.65684909
117cytokine secretion (GO:0050663)2.65048357
118regulation of mast cell activation involved in immune response (GO:0033006)2.63638067
119regulation of myeloid leukocyte mediated immunity (GO:0002886)2.62665956
120positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.62306130
121regulation of hypersensitivity (GO:0002883)2.61481236
122intestinal absorption (GO:0050892)2.60837488
123apoptotic cell clearance (GO:0043277)2.59582439
124sodium ion export (GO:0071436)2.58252825
125positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.58144069
126neutrophil chemotaxis (GO:0030593)2.57693168
127regulation of interleukin-8 biosynthetic process (GO:0045414)2.57459303
128regulation of RIG-I signaling pathway (GO:0039535)2.57374395
129phagosome maturation (GO:0090382)2.57189521
130carnitine shuttle (GO:0006853)2.56654596
131positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.56481055
132positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.56411111
133detection of biotic stimulus (GO:0009595)2.55106032
134negative regulation of fatty acid transport (GO:2000192)2.54541885
135negative regulation of keratinocyte proliferation (GO:0010839)2.52972138
136regulation of cholesterol homeostasis (GO:2000188)2.52616889
137positive regulation of glycoprotein metabolic process (GO:1903020)2.52568017
138regulation of pigment cell differentiation (GO:0050932)2.52488136
139carnitine transport (GO:0015879)2.50996960
140amino-acid betaine transport (GO:0015838)2.50996960
141auditory receptor cell differentiation (GO:0042491)2.50240496
142regulation of ARF protein signal transduction (GO:0032012)2.49710914
143negative regulation of dendrite development (GO:2000171)2.48408123
144peptidyl-threonine modification (GO:0018210)2.46809560
145neurotransmitter-gated ion channel clustering (GO:0072578)2.46258072
146dopamine receptor signaling pathway (GO:0007212)2.44165644
147COPII vesicle coating (GO:0048208)2.41817025
148regulation of RNA export from nucleus (GO:0046831)2.41140095
149cell migration in hindbrain (GO:0021535)2.38755844
150phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.38033874
151regulation of transforming growth factor beta2 production (GO:0032909)2.37902465
152adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.37373508
153negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.37244088
154dendritic spine morphogenesis (GO:0060997)2.36548321
155cellular sodium ion homeostasis (GO:0006883)2.35958285
156positive regulation of nitric-oxide synthase activity (GO:0051000)2.35562293
157intracellular lipid transport (GO:0032365)2.34736040
158asymmetric protein localization (GO:0008105)2.34505763
159establishment of nucleus localization (GO:0040023)2.34018189
160very-low-density lipoprotein particle assembly (GO:0034379)2.33620453
161detection of calcium ion (GO:0005513)2.33572065
162central nervous system projection neuron axonogenesis (GO:0021952)2.33451502
163ionotropic glutamate receptor signaling pathway (GO:0035235)2.33071155
164histone H3-K36 demethylation (GO:0070544)2.30993787
165regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.30029322
166carnitine transmembrane transport (GO:1902603)2.29896857
167glutamate secretion (GO:0014047)2.29373762
168regulation of short-term neuronal synaptic plasticity (GO:0048172)2.29353402
169negative regulation of cytosolic calcium ion concentration (GO:0051481)2.28715289
170presynaptic membrane assembly (GO:0097105)2.28320835
171regulation of nucleobase-containing compound transport (GO:0032239)2.27426813
172dendrite morphogenesis (GO:0048813)2.26415264
173positive regulation of glucose import (GO:0046326)2.25996503
174lipoprotein transport (GO:0042953)2.25411851
175vocalization behavior (GO:0071625)2.24633045
176positive regulation of glucose transport (GO:0010828)2.22466367
177insulin-like growth factor receptor signaling pathway (GO:0048009)2.22347117
178glucocorticoid biosynthetic process (GO:0006704)2.21712291
179peptidyl-threonine phosphorylation (GO:0018107)2.21655494
180neuron remodeling (GO:0016322)2.21548288
181epithelial cell-cell adhesion (GO:0090136)2.21542762
182cardiac muscle cell action potential (GO:0086001)2.21105006
183response to nerve growth factor (GO:1990089)2.20904298
184cellular response to nerve growth factor stimulus (GO:1990090)2.20904298
185cardiac muscle cell action potential involved in contraction (GO:0086002)2.19955503
186regulation of keratinocyte proliferation (GO:0010837)2.17506223
187gastrulation with mouth forming second (GO:0001702)2.17407583
188regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.16421641
189N-glycan processing (GO:0006491)2.15645921
190columnar/cuboidal epithelial cell development (GO:0002066)2.14425883
191negative regulation of potassium ion transmembrane transport (GO:1901380)2.13984768
192labyrinthine layer development (GO:0060711)2.13013978
193regulation of Rac protein signal transduction (GO:0035020)2.12832816
194glucocorticoid metabolic process (GO:0008211)2.12361736
195innervation (GO:0060384)2.12105750
196mitotic sister chromatid cohesion (GO:0007064)2.11259397
197regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.10847405
198nuclear pore complex assembly (GO:0051292)2.10140449
199Golgi to endosome transport (GO:0006895)2.09390022
200regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.09304184

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.83929041
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.76344739
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.43809272
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.99991949
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.69227674
6Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.63302414
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.39264405
8RBPJ_22232070_ChIP-Seq_NCS_Mouse3.30741311
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.12318163
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.02445611
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.91762196
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.73772558
13RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.72407121
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.68483348
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.65791352
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.56829664
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.56105023
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.54752462
19SMAD_19615063_ChIP-ChIP_OVARY_Human2.43688895
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.41213315
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.20003466
22GBX2_23144817_ChIP-Seq_PC3_Human2.14798536
23TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.13233358
24TP63_17297297_ChIP-ChIP_HaCaT_Human1.98966475
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.98954203
26VDR_24787735_ChIP-Seq_THP-1_Human1.87619618
27ESR1_20079471_ChIP-ChIP_T-47D_Human1.80625085
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.76881936
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.74707068
30TRIM28_21343339_ChIP-Seq_HEK293_Human1.60817613
31CTNNB1_20460455_ChIP-Seq_HCT116_Human1.60270973
32PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.59360935
33NRF2_20460467_ChIP-Seq_MEFs_Mouse1.55076856
34NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.55076856
35YAP1_20516196_ChIP-Seq_MESCs_Mouse1.54243390
36BRD4_27068464_Chip-Seq_AML-cells_Mouse1.52267154
37FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.52157401
38EP300_21415370_ChIP-Seq_HL-1_Mouse1.52137330
39SOX2_27498859_Chip-Seq_STOMACH_Mouse1.52086870
40PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.50767420
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.49851235
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.48186521
43NR3C1_23031785_ChIP-Seq_PC12_Mouse1.43331758
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.43293625
45SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.42576373
46STAT4_19710469_ChIP-ChIP_TH1__Mouse1.41239326
47PU_27001747_Chip-Seq_BMDM_Mouse1.40670190
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40010696
49WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.38202664
50STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.36034993
51RARB_27405468_Chip-Seq_BRAIN_Mouse1.35945813
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.35724784
53ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.34478019
54SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33993582
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33963601
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30938953
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.30444975
58CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.30262020
59AR_21572438_ChIP-Seq_LNCaP_Human1.29939211
60CJUN_26792858_Chip-Seq_BT549_Human1.29003993
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28592925
62SPI1_23127762_ChIP-Seq_K562_Human1.27471918
63JARID2_20064375_ChIP-Seq_MESCs_Mouse1.27125171
64ESR2_21235772_ChIP-Seq_MCF-7_Human1.26077698
65ZNF263_19887448_ChIP-Seq_K562_Human1.26036337
66DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.25887541
67FOXA2_19822575_ChIP-Seq_HepG2_Human1.25832361
68TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.25436486
69TP53_16413492_ChIP-PET_HCT116_Human1.25034565
70GATA2_21666600_ChIP-Seq_HMVEC_Human1.24732336
71AR_21909140_ChIP-Seq_LNCAP_Human1.23165373
72SOX2_20726797_ChIP-Seq_SW620_Human1.22515733
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.22206992
74CLOCK_20551151_ChIP-Seq_293T_Human1.20491963
75CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.20316396
76* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19939560
77STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.19473871
78EZH2_18974828_ChIP-Seq_MESCs_Mouse1.19428112
79RNF2_18974828_ChIP-Seq_MESCs_Mouse1.19428112
80TAF15_26573619_Chip-Seq_HEK293_Human1.19357735
81NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.18874292
82WT1_19549856_ChIP-ChIP_CCG9911_Human1.18092795
83TP53_18474530_ChIP-ChIP_U2OS_Human1.14973765
84DROSHA_22980978_ChIP-Seq_HELA_Human1.14540155
85GATA1_22025678_ChIP-Seq_K562_Human1.14243322
86EZH2_27304074_Chip-Seq_ESCs_Mouse1.14140046
87SOX2_21211035_ChIP-Seq_LN229_Gbm1.14035249
88AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.13960704
89TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13874499
90ISL1_27105846_Chip-Seq_CPCs_Mouse1.12775173
91SMAD3_21741376_ChIP-Seq_HESCs_Human1.11803406
92SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.11549336
93HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11325982
94PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.11064369
95CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10799574
96TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10767717
97REST_21632747_ChIP-Seq_MESCs_Mouse1.10088043
98ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.10085620
99FUS_26573619_Chip-Seq_HEK293_Human1.09889225
100SOX9_24532713_ChIP-Seq_HFSC_Mouse1.08874717
101* SPI1_23547873_ChIP-Seq_NB4_Human1.08343237
102ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.08251893
103RING1B_27294783_Chip-Seq_NPCs_Mouse1.08202617
104LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07893646
105RNF2_27304074_Chip-Seq_ESCs_Mouse1.07326517
106TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07279251
107STAT3_23295773_ChIP-Seq_U87_Human1.06099224
108NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.05826937
109RUNX_20019798_ChIP-Seq_JUKART_Human1.05799132
110SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.05612336
111SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05583547
112SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.05541935
113CBX2_27304074_Chip-Seq_ESCs_Mouse1.04983343
114FOXA1_25552417_ChIP-Seq_VCAP_Human1.04822902
115MTF2_20144788_ChIP-Seq_MESCs_Mouse1.04465172
116SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.04109124
117SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.04109124
118FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.03234367
119RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02959185
120NANOG_18555785_Chip-Seq_ESCs_Mouse1.02811129
121CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02764852
122SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.02691914
123IGF1R_20145208_ChIP-Seq_DFB_Human1.02397485
124ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01898818
125RXR_22108803_ChIP-Seq_LS180_Human1.01834432
126PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00774341
127FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.00479964
128AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00380089
129THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00048357
130BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99797528
131CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.98557026
132BRD4_25478319_ChIP-Seq_HGPS_Human0.97209464
133CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96638097
134VDR_24763502_ChIP-Seq_THP-1_Human0.96600931
135MYB_26560356_Chip-Seq_TH2_Human0.95504696
136TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90817547
137GATA3_26560356_Chip-Seq_TH2_Human0.90271192
138JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89943433
139CDX2_20551321_ChIP-Seq_CACO-2_Human0.88956642
140IKZF1_21737484_ChIP-ChIP_HCT116_Human0.87953334
141TP63_23658742_ChIP-Seq_EP156T_Human0.87143985
142CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86926161
143JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85380563
144SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.83269985
145TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.82687393
146FOXO3_23340844_ChIP-Seq_DLD1_Human0.79596812
147SALL4_18804426_ChIP-ChIP_XEN_Mouse0.79271085
148SMAD4_21799915_ChIP-Seq_A2780_Human0.79140286
149FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.78313474
150PIAS1_25552417_ChIP-Seq_VCAP_Human0.78126372
151RUNX1_22412390_ChIP-Seq_EML_Mouse0.77455618
152PPAR_26484153_Chip-Seq_NCI-H1993_Human0.76407789
153SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75909797
154PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.75906867
155SMRT_27268052_Chip-Seq_Bcells_Human0.75454232
156SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.72419912
157FOXM1_26456572_ChIP-Seq_MCF-7_Human0.72335152
158ARNT_22903824_ChIP-Seq_MCF-7_Human0.71806845
159AHR_22903824_ChIP-Seq_MCF-7_Human0.71370090
160MYB_26560356_Chip-Seq_TH1_Human0.71022337
161ESR1_21235772_ChIP-Seq_MCF-7_Human0.70907923
162GATA3_27048872_Chip-Seq_THYMUS_Human0.70831136
163GATA4_25053715_ChIP-Seq_YYC3_Human0.70396896
164TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.70267319
165TCF4_18268006_ChIP-ChIP_LS174T_Human0.68677686
166GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66979153
167E2F1_18555785_Chip-Seq_ESCs_Mouse0.66591890
168GATA2_19941826_ChIP-Seq_K562_Human0.66519603
169TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.66313961

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.31998795
2MP0003436_decreased_susceptibility_to3.97628968
3MP0001835_abnormal_antigen_presentation3.90089793
4MP0005409_darkened_coat_color3.85451874
5MP0003303_peritoneal_inflammation3.65402818
6MP0009785_altered_susceptibility_to3.47772910
7MP0004270_analgesia3.37243240
8MP0004264_abnormal_extraembryonic_tissu3.24625831
9MP0002148_abnormal_hypersensitivity_rea3.24592539
10MP0002419_abnormal_innate_immunity3.10062872
11MP0002009_preneoplasia2.87695377
12MP0002822_catalepsy2.76371239
13MP0005000_abnormal_immune_tolerance2.75314231
14MP0006082_CNS_inflammation2.69685223
15MP0005025_abnormal_response_to2.58055269
16MP0001188_hyperpigmentation2.53359594
17MP0005058_abnormal_lysosome_morphology2.53212622
18MP0004510_myositis2.50690147
19MP0003123_paternal_imprinting2.49138660
20MP0005387_immune_system_phenotype2.41710186
21MP0001790_abnormal_immune_system2.41710186
22MP0003724_increased_susceptibility_to2.41212908
23MP0003172_abnormal_lysosome_physiology2.25965295
24MP0002006_tumorigenesis2.24325717
25MP0002452_abnormal_antigen_presenting2.22586783
26MP0001533_abnormal_skeleton_physiology2.20554768
27MP0000685_abnormal_immune_system2.19748518
28MP0004947_skin_inflammation2.18926428
29MP0000566_synostosis2.14872820
30MP0005076_abnormal_cell_differentiation2.14161252
31MP0002909_abnormal_adrenal_gland2.13124407
32MP0003890_abnormal_embryonic-extraembry2.11907107
33MP0000537_abnormal_urethra_morphology2.05357744
34MP0003283_abnormal_digestive_organ2.01682824
35MP0001666_abnormal_nutrient_absorption1.99289208
36MP0002723_abnormal_immune_serum1.98418675
37MP0009764_decreased_sensitivity_to1.97150273
38MP0010678_abnormal_skin_adnexa1.94236347
39MP0000462_abnormal_digestive_system1.92421020
40MP0003941_abnormal_skin_development1.88493691
41MP0003448_altered_tumor_morphology1.86303131
42MP0009278_abnormal_bone_marrow1.84862610
43MP0001800_abnormal_humoral_immune1.84185303
44MP0000604_amyloidosis1.83551215
45MP0003315_abnormal_perineum_morphology1.81791342
46MP0002998_abnormal_bone_remodeling1.80418671
47MP0003868_abnormal_feces_composition1.80066107
48MP0001819_abnormal_immune_cell1.79044891
49MP0003183_abnormal_peptide_metabolism1.77997787
50MP0000858_altered_metastatic_potential1.76323043
51MP0003075_altered_response_to1.75937492
52MP0002420_abnormal_adaptive_immunity1.72412005
53MP0001845_abnormal_inflammatory_respons1.72103502
54MP0009780_abnormal_chondrocyte_physiolo1.70417839
55MP0003705_abnormal_hypodermis_morpholog1.70067858
56MP0003300_gastrointestinal_ulcer1.69059614
57MP0005464_abnormal_platelet_physiology1.64683678
58MP0005310_abnormal_salivary_gland1.64362197
59MP0010352_gastrointestinal_tract_polyps1.60368377
60MP0002166_altered_tumor_susceptibility1.57183670
61MP0010155_abnormal_intestine_physiology1.56792365
62MP0010307_abnormal_tumor_latency1.55402409
63MP0005671_abnormal_response_to1.51799178
64MP0003122_maternal_imprinting1.51187119
65MP0004858_abnormal_nervous_system1.50416518
66MP0003091_abnormal_cell_migration1.48800922
67MP0003787_abnormal_imprinting1.45892290
68MP0002139_abnormal_hepatobiliary_system1.45825350
69MP0002796_impaired_skin_barrier1.45727235
70MP0005360_urolithiasis1.42834247
71MP0008469_abnormal_protein_level1.40169166
72MP0003635_abnormal_synaptic_transmissio1.36937201
73MP0008438_abnormal_cutaneous_collagen1.36006106
74MP0000579_abnormal_nail_morphology1.35180754
75MP0000778_abnormal_nervous_system1.34739574
76MP0002405_respiratory_system_inflammati1.34556081
77MP0005166_decreased_susceptibility_to1.33577088
78MP0003880_abnormal_central_pattern1.31561136
79MP0003566_abnormal_cell_adhesion1.30901762
80MP0002098_abnormal_vibrissa_morphology1.29508952
81MP0002184_abnormal_innervation1.28459821
82MP0001664_abnormal_digestion1.28203863
83MP0000343_altered_response_to1.27350286
84MP0005164_abnormal_response_to1.27157610
85MP0010386_abnormal_urinary_bladder1.24238711
86MP0002277_abnormal_respiratory_mucosa1.22987806
87MP0009379_abnormal_foot_pigmentation1.21309502
88MP0005397_hematopoietic_system_phenotyp1.18806977
89MP0001545_abnormal_hematopoietic_system1.18806977
90MP0004084_abnormal_cardiac_muscle1.18718731
91MP0005390_skeleton_phenotype1.18296168
92MP0008057_abnormal_DNA_replication1.18091881
93MP0002734_abnormal_mechanical_nocicepti1.16456633
94MP0005167_abnormal_blood-brain_barrier1.15491239
95MP0000383_abnormal_hair_follicle1.13712100
96MP0001958_emphysema1.12691212
97MP0002877_abnormal_melanocyte_morpholog1.09550269
98MP0000716_abnormal_immune_system1.09235615
99MP0005257_abnormal_intraocular_pressure1.08499799
100MP0002063_abnormal_learning/memory/cond1.08480651
101MP0005187_abnormal_penis_morphology1.08166548
102MP0002254_reproductive_system_inflammat1.07743333
103MP0001853_heart_inflammation1.05070391
104MP0003191_abnormal_cellular_cholesterol1.03214423
105MP0000371_diluted_coat_color1.02287869
106MP0005174_abnormal_tail_pigmentation1.01829694
107MP0003121_genomic_imprinting1.01614184
108MP0002896_abnormal_bone_mineralization0.97098185
109MP0005386_behavior/neurological_phenoty0.95784783
110MP0004924_abnormal_behavior0.95784783
111MP0004782_abnormal_surfactant_physiolog0.95008114
112MP0000538_abnormal_urinary_bladder0.94391448
113MP0005085_abnormal_gallbladder_physiolo0.93593651
114MP0004185_abnormal_adipocyte_glucose0.93354269
115MP0002138_abnormal_hepatobiliary_system0.93256665
116MP0003045_fibrosis0.91150808
117MP0004811_abnormal_neuron_physiology0.90307379
118MP0002398_abnormal_bone_marrow0.88561285
119MP0000955_abnormal_spinal_cord0.88045505
120MP0001944_abnormal_pancreas_morphology0.87987486
121MP0000015_abnormal_ear_pigmentation0.87861435
122MP0004883_abnormal_blood_vessel0.87088808
123MP0004215_abnormal_myocardial_fiber0.86519080
124MP0002064_seizures0.86230717
125MP0001216_abnormal_epidermal_layer0.84154361
126MP0003453_abnormal_keratinocyte_physiol0.83338449
127MP0005220_abnormal_exocrine_pancreas0.80885156
128MP0009763_increased_sensitivity_to0.80403445
129MP0000762_abnormal_tongue_morphology0.80363351
130MP0000377_abnormal_hair_follicle0.80313227
131MP0001501_abnormal_sleep_pattern0.77897337
132MP0001348_abnormal_lacrimal_gland0.77671728
133MP0001177_atelectasis0.77446678
134MP0005666_abnormal_adipose_tissue0.77061273
135MP0003632_abnormal_nervous_system0.76849252
136MP0005023_abnormal_wound_healing0.75430668
137MP0000477_abnormal_intestine_morphology0.75088518
138MP0000534_abnormal_ureter_morphology0.74938662
139MP0002429_abnormal_blood_cell0.74755805
140MP0003795_abnormal_bone_structure0.74578048
141MP0004484_altered_response_of0.74204450
142MP0003828_pulmonary_edema0.74042788
143MP0010630_abnormal_cardiac_muscle0.73837213
144MP0003634_abnormal_glial_cell0.73671417
145MP0003385_abnormal_body_wall0.73507792
146MP0004085_abnormal_heartbeat0.72919421
147MP0000767_abnormal_smooth_muscle0.71996707
148MP0000249_abnormal_blood_vessel0.71393239
149MP0003943_abnormal_hepatobiliary_system0.71005925
150MP0003935_abnormal_craniofacial_develop0.70910757
151MP0002295_abnormal_pulmonary_circulatio0.70820033
152MP0005365_abnormal_bile_salt0.70560212
153MP0001984_abnormal_olfaction0.69822334
154MP0009703_decreased_birth_body0.68785439
155MP0003329_amyloid_beta_deposits0.68606089
156MP0002136_abnormal_kidney_physiology0.68535902
157MP0003861_abnormal_nervous_system0.68470282
158MP0002882_abnormal_neuron_morphology0.67924079
159MP0005248_abnormal_Harderian_gland0.67206456
160MP0009672_abnormal_birth_weight0.67015714
161MP0005197_abnormal_uvea_morphology0.66945109
162MP0004859_abnormal_synaptic_plasticity0.66923814
163MP0008004_abnormal_stomach_pH0.66555356
164MP0001765_abnormal_ion_homeostasis0.66265573
165MP0000470_abnormal_stomach_morphology0.65701151
166MP0002572_abnormal_emotion/affect_behav0.65658459
167MP0006054_spinal_hemorrhage0.65636711
168MP0002876_abnormal_thyroid_physiology0.65374732
169MP0009840_abnormal_foam_cell0.63798317
170MP0003195_calcinosis0.63368784
171MP0002081_perinatal_lethality0.63137607
172MP0002557_abnormal_social/conspecific_i0.62960822
173MP0002735_abnormal_chemical_nociception0.61986855
174MP0008569_lethality_at_weaning0.61706621
175MP0002168_other_aberrant_phenotype0.61454378
176MP0000427_abnormal_hair_cycle0.61241813
177MP0000516_abnormal_urinary_system0.59430856
178MP0005367_renal/urinary_system_phenotyp0.59430856
179MP0000689_abnormal_spleen_morphology0.56985925
180MP0000627_abnormal_mammary_gland0.56135557
181MP0002722_abnormal_immune_system0.55788659
182MP0010234_abnormal_vibrissa_follicle0.55564513

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.90254795
2Recurrent bacterial skin infections (HP:0005406)6.57444363
3Eczematoid dermatitis (HP:0000976)6.47129126
4Recurrent gram-negative bacterial infections (HP:0005420)5.75155928
5Right ventricular cardiomyopathy (HP:0011663)5.12509582
6Autoimmune thrombocytopenia (HP:0001973)4.89297053
7Mediastinal lymphadenopathy (HP:0100721)4.72055156
8Prostate neoplasm (HP:0100787)4.47348860
9Abnormality of macrophages (HP:0004311)4.37266367
10Gingivitis (HP:0000230)4.23447089
11Papillary thyroid carcinoma (HP:0002895)3.76199535
12Orchitis (HP:0100796)3.64516336
13Periodontitis (HP:0000704)3.63687858
14Recurrent skin infections (HP:0001581)3.57661716
15Optic neuritis (HP:0100653)3.57006325
16Retrobulbar optic neuritis (HP:0100654)3.57006325
17Disinhibition (HP:0000734)3.46115051
18Absent frontal sinuses (HP:0002688)3.37970184
19Myositis (HP:0100614)3.34187306
20Vacuolated lymphocytes (HP:0001922)3.33956140
21Insidious onset (HP:0003587)3.25165728
22Termporal pattern (HP:0011008)3.25165728
23Recurrent fungal infections (HP:0002841)3.23297273
24Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.23149662
25Flat acetabular roof (HP:0003180)3.11753853
26Asymmetry of the thorax (HP:0001555)3.08972901
27Obstructive lung disease (HP:0006536)3.07195621
28Chronic obstructive pulmonary disease (HP:0006510)3.07195621
29Elevated erythrocyte sedimentation rate (HP:0003565)3.04904343
30Increased cerebral lipofuscin (HP:0011813)3.03673587
31Increased IgM level (HP:0003496)3.01680811
32Macroorchidism (HP:0000053)3.01027781
33Curly hair (HP:0002212)3.00197226
34Germ cell neoplasia (HP:0100728)2.97573080
35Systemic lupus erythematosus (HP:0002725)2.96845505
36Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.92652957
37Thick nail (HP:0001805)2.86872562
38Thyroid carcinoma (HP:0002890)2.85917015
39Stomatitis (HP:0010280)2.83715948
40Spinal cord lesions (HP:0100561)2.82633239
41Syringomyelia (HP:0003396)2.82633239
42Hepatoblastoma (HP:0002884)2.77702281
43Increased neuronal autofluorescent lipopigment (HP:0002074)2.73698412
44Recurrent viral infections (HP:0004429)2.71404161
45Vasculitis (HP:0002633)2.68997659
46Pulmonary infiltrates (HP:0002113)2.65254499
47Urinary urgency (HP:0000012)2.57724681
48Peritonitis (HP:0002586)2.57644660
49Basal ganglia calcification (HP:0002135)2.57468652
50Abnormal pancreas size (HP:0012094)2.56295749
51Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.55281090
52Syncope (HP:0001279)2.54815937
53Arterial thrombosis (HP:0004420)2.50782817
54Spondylolisthesis (HP:0003302)2.49391342
55Myocardial infarction (HP:0001658)2.49349252
56Dysmetric saccades (HP:0000641)2.46670976
57Sudden death (HP:0001699)2.46248748
58Tetraparesis (HP:0002273)2.45977653
59Thin bony cortex (HP:0002753)2.44847589
60Agnosia (HP:0010524)2.44006238
61Premature loss of primary teeth (HP:0006323)2.42029945
62Glomerulonephritis (HP:0000099)2.41453595
63Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.40306654
64Osteolytic defects of the hand bones (HP:0009699)2.38152186
65Osteolytic defects of the phalanges of the hand (HP:0009771)2.38152186
66Pheochromocytoma (HP:0002666)2.34947790
67Cortical dysplasia (HP:0002539)2.34257989
68Neonatal hypoglycemia (HP:0001998)2.33191254
69Heterotopia (HP:0002282)2.30802514
70Dysostosis multiplex (HP:0000943)2.30270225
71Hypoglycemic seizures (HP:0002173)2.29316767
72Axonal loss (HP:0003447)2.29057481
73Ankyloglossia (HP:0010296)2.27957615
74Action tremor (HP:0002345)2.27690532
75Bundle branch block (HP:0011710)2.27597785
76Urticaria (HP:0001025)2.25976270
77Pustule (HP:0200039)2.25525705
78Hematochezia (HP:0002573)2.25383065
79Abnormality of the frontal sinuses (HP:0002687)2.22544841
80Inappropriate behavior (HP:0000719)2.22483239
81Subacute progressive viral hepatitis (HP:0006572)2.21508872
82Bone pain (HP:0002653)2.21383239
83Absent eyebrow (HP:0002223)2.21163358
84Urinary glycosaminoglycan excretion (HP:0003541)2.19274541
85Mucopolysacchariduria (HP:0008155)2.19274541
86Nephritis (HP:0000123)2.18593845
87Thoracic kyphosis (HP:0002942)2.17662229
88Abnormality of the gastric mucosa (HP:0004295)2.16480707
89Abnormality of the prostate (HP:0008775)2.16123133
90Hypoplasia of dental enamel (HP:0006297)2.15919406
91Osteomyelitis (HP:0002754)2.15471847
92Frequent falls (HP:0002359)2.14548913
93Abnormality of glycolipid metabolism (HP:0010969)2.12969899
94Abnormality of liposaccharide metabolism (HP:0010968)2.12969899
95Abnormality of glycosphingolipid metabolism (HP:0004343)2.12969899
96Abnormality of glycosaminoglycan metabolism (HP:0004371)2.11381996
97Abnormality of mucopolysaccharide metabolism (HP:0011020)2.11381996
98Abnormality of polysaccharide metabolism (HP:0011012)2.11381996
99Abnormality of the pericardium (HP:0001697)2.10643314
100Vertebral compression fractures (HP:0002953)2.09826344
101Neurofibrillary tangles (HP:0002185)2.07301001
102Interstitial pulmonary disease (HP:0006530)2.07024382
103Symptomatic seizures (HP:0011145)2.06645750
104Acute lymphatic leukemia (HP:0006721)2.06540795
105Hyperparathyroidism (HP:0000843)2.03607166
106Abnormality of the thoracic spine (HP:0100711)2.03304633
107Chronic mucocutaneous candidiasis (HP:0002728)2.01544195
108Recurrent cutaneous fungal infections (HP:0011370)2.01544195
109Abnormality of proline metabolism (HP:0010907)2.01080275
110Hydroxyprolinuria (HP:0003080)2.01080275
111Joint hemorrhage (HP:0005261)2.00549320
112Hypergammaglobulinemia (HP:0010702)2.00113758
113Leukocytosis (HP:0001974)1.99988932
114Bilateral sensorineural hearing impairment (HP:0008619)1.99328863
115Drooling (HP:0002307)1.98971724
116Keratoconjunctivitis sicca (HP:0001097)1.98432061
117Urinary bladder sphincter dysfunction (HP:0002839)1.97043725
118Cellulitis (HP:0100658)1.96936511
119Testicular neoplasm (HP:0010788)1.96514393
120Hyperventilation (HP:0002883)1.96254561
121Ventricular fibrillation (HP:0001663)1.95400819
122Abnormality of the nasal septum (HP:0000419)1.95152179
123Gingival bleeding (HP:0000225)1.95056927
124Impaired vibration sensation in the lower limbs (HP:0002166)1.94553268
125Hypoglycemic coma (HP:0001325)1.93990836
126Relative macrocephaly (HP:0004482)1.93264804
127Resting tremor (HP:0002322)1.93125232
128Malnutrition (HP:0004395)1.91385387
129Cerebral inclusion bodies (HP:0100314)1.91056520
130Abnormality of the corticospinal tract (HP:0002492)1.87236658
131Cystic hygroma (HP:0000476)1.87104604
132Ankle clonus (HP:0011448)1.86172016
133Enlarged penis (HP:0000040)1.86098510
134Milia (HP:0001056)1.85904110
135Pathologic fracture (HP:0002756)1.82695015
136Gastrointestinal infarctions (HP:0005244)1.82590202
137Excessive salivation (HP:0003781)1.81513533
138Recurrent pneumonia (HP:0006532)1.81409378
139Apathy (HP:0000741)1.79426881
140Cervical subluxation (HP:0003308)1.78943448
141Ventricular tachycardia (HP:0004756)1.78523376
142Dysdiadochokinesis (HP:0002075)1.77783262
143Hemoptysis (HP:0002105)1.76857347
144Abnormality of the left ventricular outflow tract (HP:0011103)1.75887036
145Subaortic stenosis (HP:0001682)1.75887036
146Plantar hyperkeratosis (HP:0007556)1.75279502
147Keratoconjunctivitis (HP:0001096)1.73460647
148Akinesia (HP:0002304)1.73216500
149Proximal tubulopathy (HP:0000114)1.72851944
150Diminished motivation (HP:0000745)1.72482594
151Meningitis (HP:0001287)1.71821790
152Abnormal tarsal ossification (HP:0008369)1.71372753
153Absent eyelashes (HP:0000561)1.71270771
154Depression (HP:0000716)1.70646522
155Progressive visual loss (HP:0000529)1.69778136
156Hyperinsulinemic hypoglycemia (HP:0000825)1.69365456
157Eosinophilia (HP:0001880)1.69164195
158Joint swelling (HP:0001386)1.69070703
159Cubitus valgus (HP:0002967)1.68227161
160Epileptiform EEG discharges (HP:0011182)1.67726650
161Vertebral arch anomaly (HP:0008438)1.67597427
162Abnormal foot bone ossification (HP:0010675)1.67370534
163Coarse hair (HP:0002208)1.66938824
164Absent speech (HP:0001344)1.66787110
165Abdominal distention (HP:0003270)1.66538976
166Pili torti (HP:0003777)1.65930987
167Febrile seizures (HP:0002373)1.65680354
168Abnormality of the pancreatic islet cells (HP:0006476)1.65401103
169Abnormality of endocrine pancreas physiology (HP:0012093)1.65401103
170Exotropia (HP:0000577)1.65119732
171Abnormality of the distal phalanx of the thumb (HP:0009617)1.65096794
172Lower limb asymmetry (HP:0100559)1.64537298
173EEG with generalized epileptiform discharges (HP:0011198)1.64379273
174Visceral angiomatosis (HP:0100761)1.64324366
175Porencephaly (HP:0002132)1.64241841
176Widely patent fontanelles and sutures (HP:0004492)1.63365246
177Abnormality of calcium-phosphate metabolism (HP:0100530)1.63347394
178Lower limb hyperreflexia (HP:0002395)1.62252031
179Open mouth (HP:0000194)1.62039162
180Hemangiomatosis (HP:0007461)1.61393338
181Abnormality of the lumbar spine (HP:0100712)1.61015750
182Hyperactive renin-angiotensin system (HP:0000841)1.60804237
183Focal seizures (HP:0007359)1.60672052
184Leiomyosarcoma (HP:0100243)1.60494932
185Sporadic (HP:0003745)1.59821398
186Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.59335219
187Degeneration of the lateral corticospinal tracts (HP:0002314)1.59335219
188Hypsarrhythmia (HP:0002521)1.59066449
189Buphthalmos (HP:0000557)1.58345348
190Abnormal cortical bone morphology (HP:0003103)1.57888819
191Thickened calvaria (HP:0002684)1.57119475
192Hypercortisolism (HP:0001578)1.55423635
193Neoplasm of the thyroid gland (HP:0100031)1.55315459
194Protruding tongue (HP:0010808)1.54123254
195Lower limb muscle weakness (HP:0007340)1.52380098
196Broad-based gait (HP:0002136)1.52248373
197Fat malabsorption (HP:0002630)1.51856629
198Overgrowth (HP:0001548)1.51731788
199Impaired vibratory sensation (HP:0002495)1.51457053

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.07366220
2MAP3K144.53378390
3CASK4.44631278
4TYK22.75024201
5MAP3K132.72585324
6TBK12.64466872
7IRAK32.58089613
8IRAK42.50612501
9LATS22.44474824
10BLK2.43143049
11JAK12.26184359
12EEF2K2.18648142
13JAK32.17401334
14IKBKE2.17308780
15TAOK32.02387451
16TRIB32.02263755
17ICK1.99705544
18MST1R1.96833136
19SCYL21.96220089
20IKBKB1.87228196
21ERBB31.76430477
22STK241.72025382
23PKN21.70241651
24EPHA41.70219740
25MAP3K41.66642921
26MAP3K91.64080409
27CHUK1.63821778
28RIPK11.57552967
29BMPR21.56019198
30PBK1.55970959
31FRK1.52549672
32MAP3K101.52231192
33CAMK1G1.44933150
34PINK11.43710349
35EPHA21.39339047
36MAP2K71.39005311
37STK391.36577734
38BRD41.35693592
39RET1.33994426
40EIF2AK31.31736173
41ERN11.31548188
42SIK31.29217078
43SGK2231.27764783
44SGK4941.27764783
45FGFR31.27242209
46MAP3K121.26798893
47FGFR21.24757305
48MAP3K61.24747462
49TXK1.23596156
50CSK1.21359956
51MAP3K51.20724491
52NEK91.17147312
53PIM21.15706569
54TNIK1.14525258
55PRKD31.13992605
56KIT1.10724137
57MAP3K21.10408802
58KSR21.09944772
59DAPK21.09651806
60BMX1.08160907
61JAK21.07269557
62PTK61.05481837
63EIF2AK21.04968177
64MAP2K41.03710238
65MET1.03457950
66HCK1.03303137
67STK31.03084215
68MINK11.00572251
69LATS10.98792961
70RPS6KA40.97950829
71KSR10.95672656
72ACVR1B0.95384172
73PLK20.95314792
74NUAK10.94361089
75RPS6KB10.94285618
76NTRK10.93814147
77YES10.90140030
78FGR0.88847016
79PIK3CA0.88191873
80BMPR1B0.86622406
81CDK50.85645318
82SIK10.85322049
83ABL20.84471752
84TAOK10.82250629
85SYK0.81818837
86PRKG20.80775190
87TRPM70.75636488
88PIM10.75035247
89RPS6KA20.74566645
90FER0.73420053
91MAP3K10.73192508
92UHMK10.72824422
93SIK20.72802893
94NTRK20.72720830
95ERBB40.72640395
96CDK120.71145500
97NTRK30.70316236
98MTOR0.70005977
99TESK10.69514308
100SGK30.69350759
101MAPK100.69242105
102STK38L0.68664402
103EGFR0.66281848
104SGK20.65977380
105WNK10.65027767
106PRKCD0.64799597
107EPHB20.64461993
108FGFR40.64309579
109CSNK1E0.63286587
110MARK30.61547007
111MARK10.59097402
112CSNK1G20.58741978
113SGK10.57619457
114LYN0.57562338
115AKT30.57213615
116CAMKK10.57187914
117CSNK1A1L0.56727433
118ABL10.56468899
119PNCK0.55565707
120FES0.54459521
121MATK0.54185979
122MOS0.53112738
123MKNK20.53015676
124LCK0.51718972
125CDK30.50768540
126TTN0.50680411
127HIPK20.50585752
128STK110.50287606
129ARAF0.48876696
130ZAP700.48486232
131DAPK10.47512212
132ERBB20.46909248
133PDPK10.46835860
134PRKCE0.46492488
135MST40.46470822
136PASK0.46259083
137RPS6KB20.46094049
138ALK0.45112995
139CDK60.44899654
140PDGFRA0.44688805
141PRKCH0.44600224
142PIK3CG0.44590076
143LMTK20.44096652
144PDGFRB0.43669135
145BCR0.43174741
146FYN0.42567233
147EPHA30.42501810
148CSF1R0.42455422
149CAMK1D0.41552403
150DDR20.39775111
151TAF10.39745229
152DMPK0.39694220
153PDK10.37460903
154NEK60.36594369
155STK40.36359250
156RPS6KA30.36112847
157PRKCZ0.36023864
158RAF10.35727751
159PRKAA10.35607468
160PRKAA20.35050644
161TYRO30.34997382
162CDK140.34508313
163PRPF4B0.33962419
164EPHB10.33752472
165STK100.32934934

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.09475274
2Graft-versus-host disease_Homo sapiens_hsa053322.82999487
3Toll-like receptor signaling pathway_Homo sapiens_hsa046202.56089069
4Staphylococcus aureus infection_Homo sapiens_hsa051502.50356540
5NOD-like receptor signaling pathway_Homo sapiens_hsa046212.21520512
6Tuberculosis_Homo sapiens_hsa051522.14532900
7Legionellosis_Homo sapiens_hsa051342.06695522
8TNF signaling pathway_Homo sapiens_hsa046682.06587208
9Osteoclast differentiation_Homo sapiens_hsa043802.02688832
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.00909139
11Pertussis_Homo sapiens_hsa051332.00488582
12Allograft rejection_Homo sapiens_hsa053301.90132053
13Rheumatoid arthritis_Homo sapiens_hsa053231.87141658
14Type I diabetes mellitus_Homo sapiens_hsa049401.87053262
15Influenza A_Homo sapiens_hsa051641.83904827
16Long-term potentiation_Homo sapiens_hsa047201.82929487
17Malaria_Homo sapiens_hsa051441.79969554
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.78511477
19Renin secretion_Homo sapiens_hsa049241.77516060
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.75381529
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.72319403
22Salmonella infection_Homo sapiens_hsa051321.69245856
23Phagosome_Homo sapiens_hsa041451.68273781
24Measles_Homo sapiens_hsa051621.65729144
25Vitamin digestion and absorption_Homo sapiens_hsa049771.59248415
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.57444727
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.52314974
28Amphetamine addiction_Homo sapiens_hsa050311.50965050
29Toxoplasmosis_Homo sapiens_hsa051451.48575395
30Gap junction_Homo sapiens_hsa045401.47976850
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.46974193
32Cocaine addiction_Homo sapiens_hsa050301.46838939
33Asthma_Homo sapiens_hsa053101.42849663
34Estrogen signaling pathway_Homo sapiens_hsa049151.42409423
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.41825645
36African trypanosomiasis_Homo sapiens_hsa051431.41725467
37Lysosome_Homo sapiens_hsa041421.39066534
38Insulin secretion_Homo sapiens_hsa049111.37396263
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.35397470
40Long-term depression_Homo sapiens_hsa047301.32670836
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.31682056
42Chemokine signaling pathway_Homo sapiens_hsa040621.29614078
43Dopaminergic synapse_Homo sapiens_hsa047281.26968022
44Amoebiasis_Homo sapiens_hsa051461.24938140
45Shigellosis_Homo sapiens_hsa051311.23110182
46Apoptosis_Homo sapiens_hsa042101.21988585
47Thyroid hormone synthesis_Homo sapiens_hsa049181.18943208
48Circadian entrainment_Homo sapiens_hsa047131.18804381
49Aldosterone synthesis and secretion_Homo sapiens_hsa049251.18295516
50Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.18008690
51Herpes simplex infection_Homo sapiens_hsa051681.17409868
52Pancreatic secretion_Homo sapiens_hsa049721.15948291
53Type II diabetes mellitus_Homo sapiens_hsa049301.14385066
54Inositol phosphate metabolism_Homo sapiens_hsa005621.14174260
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.13526588
56Bile secretion_Homo sapiens_hsa049761.13388826
57Nicotine addiction_Homo sapiens_hsa050331.13124770
58Fat digestion and absorption_Homo sapiens_hsa049751.13063086
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.12013400
60Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11628394
61Glutamatergic synapse_Homo sapiens_hsa047241.10272150
62Hepatitis B_Homo sapiens_hsa051611.09569219
63Viral myocarditis_Homo sapiens_hsa054161.07631251
64Hepatitis C_Homo sapiens_hsa051601.07477429
65Fatty acid biosynthesis_Homo sapiens_hsa000611.07100777
66Glycosaminoglycan degradation_Homo sapiens_hsa005311.06401741
67Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.04643973
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03923559
69Thyroid hormone signaling pathway_Homo sapiens_hsa049191.03831449
70Glucagon signaling pathway_Homo sapiens_hsa049221.02137826
71cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01050862
72Cholinergic synapse_Homo sapiens_hsa047251.00317750
73Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.98733833
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.98058467
75B cell receptor signaling pathway_Homo sapiens_hsa046620.97095579
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.96839048
77Insulin signaling pathway_Homo sapiens_hsa049100.96313844
78Salivary secretion_Homo sapiens_hsa049700.96260588
79Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.95856149
80Hematopoietic cell lineage_Homo sapiens_hsa046400.95091171
81Renal cell carcinoma_Homo sapiens_hsa052110.93891062
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.92675943
83Gastric acid secretion_Homo sapiens_hsa049710.92337211
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.91950424
85Histidine metabolism_Homo sapiens_hsa003400.91652609
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91164114
87Choline metabolism in cancer_Homo sapiens_hsa052310.90891620
88AMPK signaling pathway_Homo sapiens_hsa041520.90092156
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.89570357
90Tight junction_Homo sapiens_hsa045300.88602191
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.88408046
92Axon guidance_Homo sapiens_hsa043600.88272690
93Renin-angiotensin system_Homo sapiens_hsa046140.87496788
94PPAR signaling pathway_Homo sapiens_hsa033200.87307030
95Autoimmune thyroid disease_Homo sapiens_hsa053200.86564815
96Protein digestion and absorption_Homo sapiens_hsa049740.85965003
97Pancreatic cancer_Homo sapiens_hsa052120.85488994
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.83885002
99Thyroid cancer_Homo sapiens_hsa052160.83399058
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83377700
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81900169
102Starch and sucrose metabolism_Homo sapiens_hsa005000.81320955
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81246388
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80517972
105Other glycan degradation_Homo sapiens_hsa005110.78827338
106Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78137484
107Chronic myeloid leukemia_Homo sapiens_hsa052200.77065412
108Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.76590582
109Mineral absorption_Homo sapiens_hsa049780.75988971
110Prolactin signaling pathway_Homo sapiens_hsa049170.75830027
111Dilated cardiomyopathy_Homo sapiens_hsa054140.75521296
112Arginine biosynthesis_Homo sapiens_hsa002200.74521289
113* Sphingolipid metabolism_Homo sapiens_hsa006000.74087703
114Melanogenesis_Homo sapiens_hsa049160.73373051
115Antigen processing and presentation_Homo sapiens_hsa046120.70649425
116Cyanoamino acid metabolism_Homo sapiens_hsa004600.70368430
117Small cell lung cancer_Homo sapiens_hsa052220.68664037
118Fatty acid metabolism_Homo sapiens_hsa012120.68007438
119Proteoglycans in cancer_Homo sapiens_hsa052050.67576388
120cAMP signaling pathway_Homo sapiens_hsa040240.67005493
121Oxytocin signaling pathway_Homo sapiens_hsa049210.66308027
122Taste transduction_Homo sapiens_hsa047420.65587651
123Collecting duct acid secretion_Homo sapiens_hsa049660.64818646
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.64252177
125Fatty acid degradation_Homo sapiens_hsa000710.63898629
126Non-small cell lung cancer_Homo sapiens_hsa052230.63532766
127Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63266553
128Circadian rhythm_Homo sapiens_hsa047100.61651188
129Acute myeloid leukemia_Homo sapiens_hsa052210.61313439
130Prion diseases_Homo sapiens_hsa050200.59997109
131mTOR signaling pathway_Homo sapiens_hsa041500.59504625
132Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57396415
133Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57377066
134Platelet activation_Homo sapiens_hsa046110.57008825
135Lysine degradation_Homo sapiens_hsa003100.56665814
136Glioma_Homo sapiens_hsa052140.56548584
137Central carbon metabolism in cancer_Homo sapiens_hsa052300.56484676
138Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56477121
139Adherens junction_Homo sapiens_hsa045200.56262335
140Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55942692
141MicroRNAs in cancer_Homo sapiens_hsa052060.55243753
142Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55218878
143Vascular smooth muscle contraction_Homo sapiens_hsa042700.52105513
144Complement and coagulation cascades_Homo sapiens_hsa046100.51698776
145Endometrial cancer_Homo sapiens_hsa052130.50769553
146GABAergic synapse_Homo sapiens_hsa047270.50018774
147Dorso-ventral axis formation_Homo sapiens_hsa043200.49636145
148Alcoholism_Homo sapiens_hsa050340.49432121
149Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.48888564
150T cell receptor signaling pathway_Homo sapiens_hsa046600.48001126
151HIF-1 signaling pathway_Homo sapiens_hsa040660.47478994
152Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.47312575
153FoxO signaling pathway_Homo sapiens_hsa040680.46998707
154Insulin resistance_Homo sapiens_hsa049310.45784441
155Adipocytokine signaling pathway_Homo sapiens_hsa049200.44802718
156Focal adhesion_Homo sapiens_hsa045100.42167604
157Caffeine metabolism_Homo sapiens_hsa002320.42167239
158Vibrio cholerae infection_Homo sapiens_hsa051100.42125722
159ErbB signaling pathway_Homo sapiens_hsa040120.40679497
160VEGF signaling pathway_Homo sapiens_hsa043700.38771472
161Synaptic vesicle cycle_Homo sapiens_hsa047210.38016702
162Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.37053855
163Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36912690
164* Sphingolipid signaling pathway_Homo sapiens_hsa040710.35977579
165Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35390845
166MAPK signaling pathway_Homo sapiens_hsa040100.34800304
167Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33376488
168Colorectal cancer_Homo sapiens_hsa052100.32781351
169GnRH signaling pathway_Homo sapiens_hsa049120.31568230
170Prostate cancer_Homo sapiens_hsa052150.30627478

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »