CES1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)7.63767827
2ethanol oxidation (GO:0006069)7.39031643
3negative regulation of fibrinolysis (GO:0051918)7.08482845
4drug catabolic process (GO:0042737)7.03135602
5primary alcohol catabolic process (GO:0034310)6.91558450
6regulation of fibrinolysis (GO:0051917)6.88449304
7regulation of protein activation cascade (GO:2000257)6.78824175
8complement activation, alternative pathway (GO:0006957)6.74994101
9polyketide metabolic process (GO:0030638)6.62201012
10doxorubicin metabolic process (GO:0044598)6.62201012
11daunorubicin metabolic process (GO:0044597)6.62201012
12ethanol metabolic process (GO:0006067)6.60679403
13regulation of complement activation (GO:0030449)6.45256134
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.38180062
15L-phenylalanine catabolic process (GO:0006559)6.38180062
16epoxygenase P450 pathway (GO:0019373)6.35420165
17cellular glucuronidation (GO:0052695)6.08705127
18erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.07580322
19L-phenylalanine metabolic process (GO:0006558)6.07580322
20aminoglycoside antibiotic metabolic process (GO:0030647)5.86356039
21omega-hydroxylase P450 pathway (GO:0097267)5.80372697
22protein carboxylation (GO:0018214)5.78723199
23peptidyl-glutamic acid carboxylation (GO:0017187)5.78723199
24glucuronate metabolic process (GO:0019585)5.76569954
25uronic acid metabolic process (GO:0006063)5.76569954
26glyoxylate metabolic process (GO:0046487)5.73312178
27fibrinolysis (GO:0042730)5.72759853
28urea metabolic process (GO:0019627)5.66801696
29nitrogen cycle metabolic process (GO:0071941)5.18228479
30drug metabolic process (GO:0017144)5.06291177
31blood coagulation, intrinsic pathway (GO:0007597)5.03201768
32urea cycle (GO:0000050)4.91387096
33negative regulation of cholesterol transport (GO:0032375)4.88905216
34negative regulation of sterol transport (GO:0032372)4.88905216
35bile acid biosynthetic process (GO:0006699)4.84801090
36axonemal dynein complex assembly (GO:0070286)4.82467703
37bile acid metabolic process (GO:0008206)4.75093527
38regulation of plasminogen activation (GO:0010755)4.55505273
39phenylpropanoid metabolic process (GO:0009698)4.51405023
40regulation of triglyceride catabolic process (GO:0010896)4.40075887
41negative regulation of blood coagulation (GO:0030195)4.35620044
42negative regulation of hemostasis (GO:1900047)4.35620044
43triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.35456367
44intestinal cholesterol absorption (GO:0030299)4.33779704
45aromatic amino acid family catabolic process (GO:0009074)4.32801397
46primary alcohol metabolic process (GO:0034308)4.29923483
47acute-phase response (GO:0006953)4.27407020
48regulation of humoral immune response (GO:0002920)4.24869896
49protein activation cascade (GO:0072376)4.24679850
50amino-acid betaine metabolic process (GO:0006577)4.23152628
51negative regulation of protein activation cascade (GO:2000258)4.21163079
52positive regulation of lipoprotein lipase activity (GO:0051006)4.12594216
53positive regulation of triglyceride lipase activity (GO:0061365)4.12594216
54triglyceride homeostasis (GO:0070328)4.08996415
55acylglycerol homeostasis (GO:0055090)4.08996415
56bile acid and bile salt transport (GO:0015721)4.05699980
57phospholipid efflux (GO:0033700)4.03540595
58flavonoid metabolic process (GO:0009812)4.02557913
59negative regulation of coagulation (GO:0050819)3.98984426
60positive regulation of blood coagulation (GO:0030194)3.97798479
61positive regulation of hemostasis (GO:1900048)3.97798479
62regulation of apoptotic cell clearance (GO:2000425)3.96707040
63complement activation (GO:0006956)3.94734878
64regulation of cholesterol esterification (GO:0010872)3.92534232
65cilium or flagellum-dependent cell motility (GO:0001539)3.92391136
66oxidative demethylation (GO:0070989)3.90115742
67protein-lipid complex remodeling (GO:0034368)3.88561249
68macromolecular complex remodeling (GO:0034367)3.88561249
69plasma lipoprotein particle remodeling (GO:0034369)3.88561249
70negative regulation of wound healing (GO:0061045)3.88229961
71serine family amino acid catabolic process (GO:0009071)3.88186875
72negative regulation of humoral immune response (GO:0002921)3.87530385
73plasma lipoprotein particle clearance (GO:0034381)3.87282562
74complement activation, classical pathway (GO:0006958)3.83613782
75very-low-density lipoprotein particle assembly (GO:0034379)3.81348096
76cholesterol efflux (GO:0033344)3.75737227
77negative regulation of lipase activity (GO:0060192)3.71846396
78positive regulation of coagulation (GO:0050820)3.68611066
79hormone catabolic process (GO:0042447)3.58669503
80high-density lipoprotein particle remodeling (GO:0034375)3.58519278
81negative regulation of complement activation (GO:0045916)3.55094809
82progesterone metabolic process (GO:0042448)3.53554357
83tyrosine metabolic process (GO:0006570)3.50510168
84xenobiotic metabolic process (GO:0006805)3.46626081
85glycoside metabolic process (GO:0016137)3.45709131
86glycine metabolic process (GO:0006544)3.44372258
87retinal metabolic process (GO:0042574)3.39277374
88response to mercury ion (GO:0046689)3.38678654
89positive regulation of extracellular matrix organization (GO:1903055)3.38630956
90acute inflammatory response (GO:0002526)3.32581996
91fat-soluble vitamin biosynthetic process (GO:0042362)3.32264012
92glutamate metabolic process (GO:0006536)3.30968419
93cysteine metabolic process (GO:0006534)3.29632662
94fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.29285854
95positive regulation of lipid catabolic process (GO:0050996)3.25066907
96S-adenosylmethionine metabolic process (GO:0046500)3.23837897
97disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.23138219
98killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.23138219
99cellular aldehyde metabolic process (GO:0006081)3.21228472
100positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.21091406

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.64267948
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.64020077
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.13240969
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.76342173
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.69179948
6* LXR_22158963_ChIP-Seq_LIVER_Mouse4.67063617
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.23552781
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.79104003
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.24751057
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.11884562
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.26776411
12FOXA2_19822575_ChIP-Seq_HepG2_Human2.19313034
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.09819601
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00598423
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.86985549
16ESR2_21235772_ChIP-Seq_MCF-7_Human1.84065492
17* HNF4A_19822575_ChIP-Seq_HepG2_Human1.79102644
18RARG_19884340_ChIP-ChIP_MEFs_Mouse1.70998061
19ESR1_20079471_ChIP-ChIP_T-47D_Human1.67850691
20TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.66299493
21CLOCK_20551151_ChIP-Seq_293T_Human1.64821972
22HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.59143077
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.59112975
24FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.56864114
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.52677605
26* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.48245047
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.43981953
28STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.39866618
29LXR_22292898_ChIP-Seq_THP-1_Human1.37196256
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.27185894
31Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.26434657
32AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.22621729
33FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.20398256
34SOX2_20726797_ChIP-Seq_SW620_Human1.18556490
35GATA4_25053715_ChIP-Seq_YYC3_Human1.18542261
36BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15423369
37SMC4_20622854_ChIP-Seq_HELA_Human1.12970214
38* CDX2_20551321_ChIP-Seq_CACO-2_Human1.12428077
39ESR1_21235772_ChIP-Seq_MCF-7_Human1.09227373
40* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.07476540
41STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.06661996
42TP63_17297297_ChIP-ChIP_HaCaT_Human1.02499073
43TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01931299
44PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.00684445
45P63_26484246_Chip-Seq_KERATINOCYTES_Human0.98358176
46IRF8_22096565_ChIP-ChIP_GC-B_Human0.98105031
47KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97178383
48TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96654614
49PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90497540
50FOXO3_23340844_ChIP-Seq_DLD1_Human0.89654827
51RAD21_21589869_ChIP-Seq_MESCs_Mouse0.89594133
52RACK7_27058665_Chip-Seq_MCF-7_Human0.89282618
53FOXA1_25552417_ChIP-Seq_VCAP_Human0.89140112
54IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.88899077
55ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88186926
56RXRA_24833708_ChIP-Seq_LIVER_Mouse0.86724885
57GATA6_25053715_ChIP-Seq_YYC3_Human0.85059763
58ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84969790
59SALL4_18804426_ChIP-ChIP_XEN_Mouse0.84525644
60DROSHA_22980978_ChIP-Seq_HELA_Human0.84236926
61SOX9_24532713_ChIP-Seq_HFSC_Mouse0.84152146
62NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.81589106
63ZNF263_19887448_ChIP-Seq_K562_Human0.81342116
64CEBPB_22108803_ChIP-Seq_LS180_Human0.81290760
65KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.80264586
66ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.79797798
67SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.78887743
68* ELF1_20517297_ChIP-Seq_JURKAT_Human0.76665752
69RUNX1_27514584_Chip-Seq_MCF-7_Human0.76634993
70TBX20_22328084_ChIP-Seq_HEART_Mouse0.76327679
71TBX20_22080862_ChIP-Seq_HEART_Mouse0.76327679
72GATA3_24758297_ChIP-Seq_MCF-7_Human0.76086975
73SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.75991722
74GATA2_21666600_ChIP-Seq_HMVEC_Human0.73327885
75SOX2_21211035_ChIP-Seq_LN229_Human0.73086666
76GATA1_19941827_ChIP-Seq_MEL_Mouse0.72958146
77NFIB_24661679_ChIP-Seq_LUNG_Mouse0.72586241
78E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.72146134
79FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.71038873
80GATA1_19941826_ChIP-Seq_K562_Human0.70465236
81SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.70399959
82HNFA_21074721_ChIP-Seq_CACO-2_Human0.68858798
83BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.68385432
84CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.67842207
85SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.66833250
86KAP1_22055183_ChIP-Seq_ESCs_Mouse0.66830243
87CTCF_27219007_Chip-Seq_Bcells_Human0.66604771
88IRF8_27001747_Chip-Seq_BMDM_Mouse0.65976871
89CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.64953278
90PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.64933828
91TP63_22573176_ChIP-Seq_HFKS_Human0.64443884
92PIAS1_25552417_ChIP-Seq_VCAP_Human0.64028708
93TP63_23658742_ChIP-Seq_EP156T_Human0.63947249
94CBP_21632823_ChIP-Seq_H3396_Human0.63776748
95ELK3_25401928_ChIP-Seq_HUVEC_Human0.62786515
96TP53_18474530_ChIP-ChIP_U2OS_Human0.62713123
97* P68_20966046_ChIP-Seq_HELA_Human0.62710697
98* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.62650750
99ERG_21242973_ChIP-ChIP_JURKAT_Human0.62240001
100CDX2_19796622_ChIP-Seq_MESCs_Mouse0.61626550

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.39623063
2MP0008875_abnormal_xenobiotic_pharmacok6.21424231
3MP0005365_abnormal_bile_salt5.56982562
4MP0005085_abnormal_gallbladder_physiolo5.35985893
5MP0005360_urolithiasis5.26343018
6MP0003195_calcinosis3.91848431
7MP0003252_abnormal_bile_duct3.34111755
8MP0003868_abnormal_feces_composition3.08466571
9MP0010329_abnormal_lipoprotein_level2.97646129
10MP0001666_abnormal_nutrient_absorption2.85600417
11MP0002138_abnormal_hepatobiliary_system2.83088572
12MP0003191_abnormal_cellular_cholesterol2.45984572
13MP0002876_abnormal_thyroid_physiology2.22571894
14MP0009840_abnormal_foam_cell2.16918567
15MP0003806_abnormal_nucleotide_metabolis2.14340238
16MP0002132_abnormal_respiratory_system2.11482101
17MP0005670_abnormal_white_adipose2.03700351
18MP0005332_abnormal_amino_acid1.91002568
19MP0004019_abnormal_vitamin_homeostasis1.88280418
20MP0000609_abnormal_liver_physiology1.87319465
21MP0002118_abnormal_lipid_homeostasis1.85102732
22MP0009697_abnormal_copulation1.53843337
23MP0001764_abnormal_homeostasis1.45836586
24MP0003656_abnormal_erythrocyte_physiolo1.41961277
25MP0002971_abnormal_brown_adipose1.39057332
26MP0009780_abnormal_chondrocyte_physiolo1.31349637
27MP0005666_abnormal_adipose_tissue1.24428351
28MP0005408_hypopigmentation1.22417829
29MP0005319_abnormal_enzyme/_coenzyme1.22233959
30MP0005058_abnormal_lysosome_morphology1.21977182
31MP0003186_abnormal_redox_activity1.18401684
32MP0009643_abnormal_urine_homeostasis1.16919558
33MP0001661_extended_life_span1.15649034
34MP0003690_abnormal_glial_cell1.14917335
35MP0010368_abnormal_lymphatic_system1.10707425
36MP0005164_abnormal_response_to1.09117172
37MP0005584_abnormal_enzyme/coenzyme_acti1.06570250
38MP0000604_amyloidosis1.05864981
39MP0005451_abnormal_body_composition1.05570449
40MP0000598_abnormal_liver_morphology0.99426153
41MP0004130_abnormal_muscle_cell0.98908221
42MP0009763_increased_sensitivity_to0.96733815
43MP0004883_abnormal_blood_vessel0.95864806
44MP0002168_other_aberrant_phenotype0.95073956
45MP0005464_abnormal_platelet_physiology0.91004617
46MP0008469_abnormal_protein_level0.90526084
47MP0003011_delayed_dark_adaptation0.90177992
48MP0001915_intracranial_hemorrhage0.89986122
49MP0005375_adipose_tissue_phenotype0.88733661
50MP0009115_abnormal_fat_cell0.87027171
51MP0003075_altered_response_to0.85363523
52MP0005376_homeostasis/metabolism_phenot0.83938922
53MP0005334_abnormal_fat_pad0.82648597
54MP0009642_abnormal_blood_homeostasis0.82074410
55MP0004782_abnormal_surfactant_physiolog0.81893280
56MP0005023_abnormal_wound_healing0.81200150
57MP0005636_abnormal_mineral_homeostasis0.80536683
58MP0000566_synostosis0.78485666
59MP0000858_altered_metastatic_potential0.78245497
60MP0003705_abnormal_hypodermis_morpholog0.76403572
61MP0000249_abnormal_blood_vessel0.76093217
62MP0009053_abnormal_anal_canal0.73304160
63MP0005395_other_phenotype0.70182884
64MP0005535_abnormal_body_temperature0.69891814
65MP0002909_abnormal_adrenal_gland0.69158581
66MP0003172_abnormal_lysosome_physiology0.63988444
67MP0002078_abnormal_glucose_homeostasis0.63012909
68MP0009785_altered_susceptibility_to0.60972872
69MP0002970_abnormal_white_adipose0.60893331
70MP0004185_abnormal_adipocyte_glucose0.60118456
71MP0003303_peritoneal_inflammation0.60026636
72MP0004043_abnormal_pH_regulation0.59992708
73MP0005083_abnormal_biliary_tract0.57183267
74MP0003959_abnormal_lean_body0.57016836
75MP0009764_decreased_sensitivity_to0.56631348
76MP0003638_abnormal_response/metabolism_0.55394633
77MP0003828_pulmonary_edema0.54920181
78MP0002282_abnormal_trachea_morphology0.54872498
79MP0002249_abnormal_larynx_morphology0.53770718
80MP0006036_abnormal_mitochondrial_physio0.53185539
81MP0003436_decreased_susceptibility_to0.53114228
82MP0003879_abnormal_hair_cell0.52593575
83MP0002419_abnormal_innate_immunity0.51248375
84MP0002136_abnormal_kidney_physiology0.50766586
85MP0003950_abnormal_plasma_membrane0.50341464
86MP0003566_abnormal_cell_adhesion0.50072299
87MP0005166_decreased_susceptibility_to0.48800010
88MP0000003_abnormal_adipose_tissue0.47948715
89MP0005448_abnormal_energy_balance0.47200903
90MP0003329_amyloid_beta_deposits0.46144508
91MP0001851_eye_inflammation0.44370991
92MP0005409_darkened_coat_color0.43692187
93MP0005167_abnormal_blood-brain_barrier0.43238041
94MP0005647_abnormal_sex_gland0.42766078
95MP0005165_increased_susceptibility_to0.41632613
96MP0002653_abnormal_ependyma_morphology0.41363284
97MP0008874_decreased_physiological_sensi0.41260688
98MP0009765_abnormal_xenobiotic_induced0.40362594
99MP0005025_abnormal_response_to0.40018133
100MP0001533_abnormal_skeleton_physiology0.38980113

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of monocarboxylic acid metabolism (HP:0010996)8.65697606
2Deep venous thrombosis (HP:0002625)8.15904856
3Complement deficiency (HP:0004431)7.74019658
4Prolonged partial thromboplastin time (HP:0003645)6.56841010
5Abnormality of complement system (HP:0005339)6.40625442
6Abnormality of aromatic amino acid family metabolism (HP:0004338)6.27274731
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.95357845
8Hypobetalipoproteinemia (HP:0003563)5.88037143
9Systemic lupus erythematosus (HP:0002725)5.59330096
10Conjugated hyperbilirubinemia (HP:0002908)5.22358284
11Abnormal respiratory motile cilium morphology (HP:0005938)5.16576438
12Abnormal respiratory epithelium morphology (HP:0012253)5.16576438
13Abnormal respiratory motile cilium physiology (HP:0012261)5.09532843
14Joint hemorrhage (HP:0005261)5.03970922
15Abnormal ciliary motility (HP:0012262)4.91684969
16Absent/shortened dynein arms (HP:0200106)4.89993650
17Dynein arm defect of respiratory motile cilia (HP:0012255)4.89993650
18Rhinitis (HP:0012384)4.88229827
19Glomerulonephritis (HP:0000099)4.85540656
20Xanthomatosis (HP:0000991)4.33152961
21Hyperlipoproteinemia (HP:0010980)4.24453544
22Abnormality of the common coagulation pathway (HP:0010990)4.19961859
23Recurrent gram-negative bacterial infections (HP:0005420)3.98470859
24Intrahepatic cholestasis (HP:0001406)3.97419591
25Chronic bronchitis (HP:0004469)3.63897369
26Hypolipoproteinemia (HP:0010981)3.59528684
27Hemorrhage of the eye (HP:0011885)3.45215082
28Nephritis (HP:0000123)3.42427525
29Spontaneous abortion (HP:0005268)3.37649475
30Fat malabsorption (HP:0002630)3.35829451
31Nasal polyposis (HP:0100582)3.34940335
32Bronchiectasis (HP:0002110)3.31763531
33Abnormality of pyrimidine metabolism (HP:0004353)3.18281754
34Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.18068746
35Rickets (HP:0002748)3.12765588
36Vascular calcification (HP:0004934)3.11735330
37Hypercholesterolemia (HP:0003124)3.08430065
38Purpura (HP:0000979)3.00585598
39Abnormality of the nasal mucosa (HP:0000433)2.91694147
40Mitral stenosis (HP:0001718)2.90489100
41Steatorrhea (HP:0002570)2.90182312
42Abnormality of glutamine family amino acid metabolism (HP:0010902)2.86420643
43Cardiovascular calcification (HP:0011915)2.76465095
44Myocardial infarction (HP:0001658)2.69102319
45Abnormality of the intrinsic pathway (HP:0010989)2.62603967
46Gingival bleeding (HP:0000225)2.61797252
47Hypoalphalipoproteinemia (HP:0003233)2.50836824
48Epidermoid cyst (HP:0200040)2.46911783
49Hyperammonemia (HP:0001987)2.37144856
50Bifid scrotum (HP:0000048)2.33663466
51Recurrent sinusitis (HP:0011108)2.32399452
52Amyloidosis (HP:0011034)2.30690326
53Osteomalacia (HP:0002749)2.26715185
54Recurrent otitis media (HP:0000403)2.24913407
55Thrombophlebitis (HP:0004418)2.19526240
56Generalized aminoaciduria (HP:0002909)2.17340719
57Menorrhagia (HP:0000132)2.13071087
58Hypertriglyceridemia (HP:0002155)2.09888252
59Skin nodule (HP:0200036)2.03505008
60Infertility (HP:0000789)2.02507443
61Bronchitis (HP:0012387)2.02173614
62Pulmonary embolism (HP:0002204)2.01697921
63Increased serum ferritin (HP:0003281)1.98670038
64Abnormality of methionine metabolism (HP:0010901)1.93291775
65Male infertility (HP:0003251)1.92661432
66Hepatocellular carcinoma (HP:0001402)1.91520616
67Abnormality of the Achilles tendon (HP:0005109)1.87742038
68Abnormality of nucleobase metabolism (HP:0010932)1.87068686
69Hyperbilirubinemia (HP:0002904)1.86169003
70Delayed CNS myelination (HP:0002188)1.85898648
71Hyperglycinemia (HP:0002154)1.83721222
72Abnormality of iron homeostasis (HP:0011031)1.82397601
73Abnormality of vitamin metabolism (HP:0100508)1.77689196
74Hypophosphatemic rickets (HP:0004912)1.74034452
75Back pain (HP:0003418)1.73754231
76Abnormality of glycine metabolism (HP:0010895)1.67936338
77Abnormality of serine family amino acid metabolism (HP:0010894)1.67936338
78Urinary glycosaminoglycan excretion (HP:0003541)1.64162927
79Mucopolysacchariduria (HP:0008155)1.64162927
80Gangrene (HP:0100758)1.62819035
81Abnormality of transition element cation homeostasis (HP:0011030)1.60217280
82Joint swelling (HP:0001386)1.58395633
83Elevated alkaline phosphatase (HP:0003155)1.56592746
84Chronic sinusitis (HP:0011109)1.55897055
85Abnormal enzyme/coenzyme activity (HP:0012379)1.55624371
86Abnormality of proline metabolism (HP:0010907)1.53888366
87Hydroxyprolinuria (HP:0003080)1.53888366
88Reduced antithrombin III activity (HP:0001976)1.53185831
89Polycythemia (HP:0001901)1.52532054
90Abnormality of carpal bone ossification (HP:0006257)1.51357163
91Polygenic inheritance (HP:0010982)1.50388254
92Abnormality of polysaccharide metabolism (HP:0011012)1.50106405
93Abnormality of glycosaminoglycan metabolism (HP:0004371)1.50106405
94Abnormality of mucopolysaccharide metabolism (HP:0011020)1.50106405
95Hyperglycinuria (HP:0003108)1.50029078
96Epistaxis (HP:0000421)1.49001564
97Atelectasis (HP:0100750)1.48957615
98Increased mean platelet volume (HP:0011877)1.48947645
99Flat acetabular roof (HP:0003180)1.48076300
100Metabolic acidosis (HP:0001942)1.45855719

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.71375416
2ERN13.82643619
3FGFR43.13968067
4TRIB32.96205084
5RIPK12.80074922
6EPHA22.76303812
7MAP3K32.12002573
8ICK2.09112824
9IRAK31.98958437
10MAP3K21.94677030
11MST1R1.89940421
12TBK11.84975837
13TYK21.81784757
14MAPKAPK31.78298689
15FGFR31.75487046
16RIPK41.71870144
17PRKAA21.67354828
18SMG11.58371141
19EEF2K1.58218901
20CSK1.53302749
21NEK91.48018421
22PRPF4B1.47314571
23SIK11.46804063
24PDPK11.40383520
25TGFBR21.35764614
26EPHA31.30153274
27CDK61.26108045
28EPHB11.25902665
29MST41.22753466
30ZAP701.22516922
31ABL21.19630853
32DDR21.12729642
33MAP3K131.10320921
34LATS11.04432603
35MAPK111.04064171
36LATS21.01998088
37MAP3K61.00996769
38PRKACG0.99257926
39MYLK0.96070123
40TRPM70.94825213
41MAP2K30.94761735
42STK380.89352448
43TESK10.88079748
44CDC42BPA0.86907583
45LRRK20.86618488
46DYRK1B0.86463611
47ERBB40.85785126
48MAP3K70.84854742
49MAP2K40.82910257
50MAP3K10.77431235
51KSR20.76978252
52PDGFRA0.76884888
53MARK20.75541414
54PDK10.74520397
55ERBB20.74152061
56PIK3CG0.73546147
57RET0.73325767
58IGF1R0.72638817
59BLK0.72305418
60JAK10.68973410
61CAMKK20.66599042
62CDK120.66525119
63ARAF0.64432100
64MAPK120.63791238
65STK240.63382725
66MET0.62087774
67STK100.61092680
68JAK20.61050364
69PKN20.60002550
70MAP3K120.55189272
71MAP3K140.54095844
72PTK60.53427754
73CSF1R0.52931813
74YES10.52915784
75GRK60.52373871
76MAP3K110.52363731
77PAK40.52109625
78PRKAA10.50775180
79SRC0.48845626
80CAMKK10.48760773
81PDGFRB0.47314662
82NLK0.46361529
83FER0.44985897
84CDK40.43721706
85CAMK1D0.43268705
86TIE10.42297908
87GSK3A0.42105969
88PRKG10.41258258
89SGK10.40906686
90MTOR0.40725868
91IRAK10.40712045
92MAPK40.39551463
93MAPK70.38203822
94PRKCZ0.37317843
95PTK20.36478715
96KIT0.33976689
97ABL10.33290267
98PRKCD0.33072543
99SGK30.32242787
100TAOK20.31588636

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046103.73520103
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.71719866
3Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.70122978
4Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.56992261
5Caffeine metabolism_Homo sapiens_hsa002323.53208920
6Primary bile acid biosynthesis_Homo sapiens_hsa001203.44996008
7Retinol metabolism_Homo sapiens_hsa008303.37117449
8Chemical carcinogenesis_Homo sapiens_hsa052043.33303826
9Phenylalanine metabolism_Homo sapiens_hsa003603.22711238
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.13620290
11Pentose and glucuronate interconversions_Homo sapiens_hsa000403.02736931
12Steroid hormone biosynthesis_Homo sapiens_hsa001402.77571426
13Tyrosine metabolism_Homo sapiens_hsa003502.76367627
14Histidine metabolism_Homo sapiens_hsa003402.61395720
15Fatty acid degradation_Homo sapiens_hsa000712.54209836
16* Drug metabolism - other enzymes_Homo sapiens_hsa009832.38401889
17Arginine biosynthesis_Homo sapiens_hsa002202.08273157
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.07964428
19PPAR signaling pathway_Homo sapiens_hsa033201.81734282
20Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.77254714
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.76281080
22Starch and sucrose metabolism_Homo sapiens_hsa005001.76088496
23Tryptophan metabolism_Homo sapiens_hsa003801.73069692
24beta-Alanine metabolism_Homo sapiens_hsa004101.71291842
25Bile secretion_Homo sapiens_hsa049761.67931204
26Butanoate metabolism_Homo sapiens_hsa006501.57878335
27Staphylococcus aureus infection_Homo sapiens_hsa051501.45495149
28Linoleic acid metabolism_Homo sapiens_hsa005911.36431207
29Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.36213401
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28419079
31Cyanoamino acid metabolism_Homo sapiens_hsa004601.26734590
32Peroxisome_Homo sapiens_hsa041461.25781923
33Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.06866825
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.04869342
35Pyruvate metabolism_Homo sapiens_hsa006201.04150851
36Vitamin B6 metabolism_Homo sapiens_hsa007501.03953113
37ABC transporters_Homo sapiens_hsa020100.99068133
38Arachidonic acid metabolism_Homo sapiens_hsa005900.98758858
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92703999
40Prion diseases_Homo sapiens_hsa050200.89563785
41Fat digestion and absorption_Homo sapiens_hsa049750.87517573
42Fatty acid metabolism_Homo sapiens_hsa012120.87453249
43Cysteine and methionine metabolism_Homo sapiens_hsa002700.87092888
44Arginine and proline metabolism_Homo sapiens_hsa003300.83994422
45Biosynthesis of amino acids_Homo sapiens_hsa012300.79399531
46Carbon metabolism_Homo sapiens_hsa012000.78516391
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.74729405
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.72944148
49Glutathione metabolism_Homo sapiens_hsa004800.71494726
50Glycerolipid metabolism_Homo sapiens_hsa005610.69430189
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68900831
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68037648
53Propanoate metabolism_Homo sapiens_hsa006400.67987911
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67691836
55Glycosaminoglycan degradation_Homo sapiens_hsa005310.61272738
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57723504
57Other glycan degradation_Homo sapiens_hsa005110.56474768
58Fructose and mannose metabolism_Homo sapiens_hsa000510.49882710
59Pertussis_Homo sapiens_hsa051330.45166793
60Lysine degradation_Homo sapiens_hsa003100.42977466
61Pentose phosphate pathway_Homo sapiens_hsa000300.42100532
62Sulfur metabolism_Homo sapiens_hsa009200.40470235
63Fatty acid biosynthesis_Homo sapiens_hsa000610.37294982
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.36417756
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.35059464
66* Metabolic pathways_Homo sapiens_hsa011000.33020112
67Insulin resistance_Homo sapiens_hsa049310.31014119
68Galactose metabolism_Homo sapiens_hsa000520.29177942
69Vitamin digestion and absorption_Homo sapiens_hsa049770.28087224
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.24473489
71Fatty acid elongation_Homo sapiens_hsa000620.23218439
72One carbon pool by folate_Homo sapiens_hsa006700.22261577
73Sulfur relay system_Homo sapiens_hsa041220.21550874
74Steroid biosynthesis_Homo sapiens_hsa001000.11811850
75AMPK signaling pathway_Homo sapiens_hsa041520.11438652
76Sphingolipid metabolism_Homo sapiens_hsa006000.11401356
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.10220307
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.09650237
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.09421159
80Renin-angiotensin system_Homo sapiens_hsa046140.09193325
81Amoebiasis_Homo sapiens_hsa051460.08065946
82Lysosome_Homo sapiens_hsa041420.07876786
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.05568462
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.00911402
85Glucagon signaling pathway_Homo sapiens_hsa049220.00294815
86Phagosome_Homo sapiens_hsa04145-0.1723856
87Malaria_Homo sapiens_hsa05144-0.1722721
88ECM-receptor interaction_Homo sapiens_hsa04512-0.1654989
89African trypanosomiasis_Homo sapiens_hsa05143-0.1620694
90Type II diabetes mellitus_Homo sapiens_hsa04930-0.1480654
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1324920
92Selenocompound metabolism_Homo sapiens_hsa00450-0.1221824
93Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1207245
94Folate biosynthesis_Homo sapiens_hsa00790-0.1095802
95Hepatitis C_Homo sapiens_hsa05160-0.0896186
96Insulin signaling pathway_Homo sapiens_hsa04910-0.0518886
97Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0357270
98Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0282352
99Mineral absorption_Homo sapiens_hsa04978-0.0133188
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0119597

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »