CES1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the carboxylesterase (CES) gene family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene does not encode a protein and the sequence is similar to the CES1 gene, so represents a pseudogene of the CES1 gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glyoxylate metabolic process (GO:0046487)8.29604823
2regulation of protein activation cascade (GO:2000257)8.11071352
3complement activation, alternative pathway (GO:0006957)7.70135113
4regulation of complement activation (GO:0030449)7.45363084
5regulation of fibrinolysis (GO:0051917)7.42156724
6L-phenylalanine catabolic process (GO:0006559)7.10770665
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.10770665
8drug catabolic process (GO:0042737)7.03119295
9negative regulation of fibrinolysis (GO:0051918)7.03055182
10urea metabolic process (GO:0019627)6.73902458
11protein carboxylation (GO:0018214)6.66176734
12peptidyl-glutamic acid carboxylation (GO:0017187)6.66176734
13L-phenylalanine metabolic process (GO:0006558)6.50903288
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.50903288
15phenylpropanoid metabolic process (GO:0009698)6.33175943
16blood coagulation, intrinsic pathway (GO:0007597)6.18677658
17bile acid biosynthetic process (GO:0006699)6.17198597
18urea cycle (GO:0000050)6.15173557
19fibrinolysis (GO:0042730)6.15058507
20nitrogen cycle metabolic process (GO:0071941)6.12202581
21epoxygenase P450 pathway (GO:0019373)6.09534411
22regulation of triglyceride catabolic process (GO:0010896)6.00450223
23exogenous drug catabolic process (GO:0042738)5.60215803
24serine family amino acid catabolic process (GO:0009071)5.47439261
25negative regulation of protein activation cascade (GO:2000258)5.46563155
26cellular glucuronidation (GO:0052695)5.42606070
27oxidative demethylation (GO:0070989)5.41041046
28acute-phase response (GO:0006953)5.40682460
29drug metabolic process (GO:0017144)5.39957575
30bile acid metabolic process (GO:0008206)5.39679716
31regulation of plasminogen activation (GO:0010755)5.38869565
32uronic acid metabolic process (GO:0006063)5.22557456
33glucuronate metabolic process (GO:0019585)5.22557456
34ethanol oxidation (GO:0006069)5.03163359
35omega-hydroxylase P450 pathway (GO:0097267)5.02278299
36protein activation cascade (GO:0072376)5.00154269
37negative regulation of complement activation (GO:0045916)4.91770072
38regulation of humoral immune response (GO:0002920)4.83305042
39triglyceride homeostasis (GO:0070328)4.81060685
40acylglycerol homeostasis (GO:0055090)4.81060685
41aromatic amino acid family catabolic process (GO:0009074)4.76711996
42glycine metabolic process (GO:0006544)4.73808781
43complement activation (GO:0006956)4.72349212
44negative regulation of blood coagulation (GO:0030195)4.71253334
45negative regulation of hemostasis (GO:1900047)4.71253334
46alkaloid metabolic process (GO:0009820)4.70718343
47negative regulation of sterol transport (GO:0032372)4.69844313
48negative regulation of cholesterol transport (GO:0032375)4.69844313
49triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.61942996
50positive regulation of lipoprotein lipase activity (GO:0051006)4.60434654
51positive regulation of triglyceride lipase activity (GO:0061365)4.60434654
52complement activation, classical pathway (GO:0006958)4.54340414
53arginine metabolic process (GO:0006525)4.52563915
54polyketide metabolic process (GO:0030638)4.48146675
55doxorubicin metabolic process (GO:0044598)4.48146675
56daunorubicin metabolic process (GO:0044597)4.48146675
57ethanol metabolic process (GO:0006067)4.47866478
58protein-lipid complex remodeling (GO:0034368)4.43509577
59macromolecular complex remodeling (GO:0034367)4.43509577
60plasma lipoprotein particle remodeling (GO:0034369)4.43509577
61cysteine metabolic process (GO:0006534)4.42109705
62negative regulation of wound healing (GO:0061045)4.38474166
63acute inflammatory response (GO:0002526)4.37114712
64phospholipid efflux (GO:0033700)4.32283004
65negative regulation of humoral immune response (GO:0002921)4.31981915
66regulation of cholesterol esterification (GO:0010872)4.31782775
67negative regulation of coagulation (GO:0050819)4.30929812
68hormone catabolic process (GO:0042447)4.23248215
69primary alcohol catabolic process (GO:0034310)4.19324170
70regulation of bile acid biosynthetic process (GO:0070857)4.19033712
71bile acid and bile salt transport (GO:0015721)4.18396300
72amino-acid betaine metabolic process (GO:0006577)4.15628326
73serine family amino acid metabolic process (GO:0009069)4.11929242
74sulfur amino acid catabolic process (GO:0000098)4.05393521
75steroid catabolic process (GO:0006706)4.02565809
76tyrosine metabolic process (GO:0006570)4.00664094
77aminoglycoside antibiotic metabolic process (GO:0030647)3.95325124
78positive regulation of blood coagulation (GO:0030194)3.89275414
79positive regulation of hemostasis (GO:1900048)3.89275414
80high-density lipoprotein particle remodeling (GO:0034375)3.89033223
81regulation of lipoprotein particle clearance (GO:0010984)3.87269014
82negative regulation of lipase activity (GO:0060192)3.85925095
83aldehyde catabolic process (GO:0046185)3.81376260
84cholesterol efflux (GO:0033344)3.76532916
85retinal metabolic process (GO:0042574)3.68209504
86cytolysis (GO:0019835)3.67927657
87positive regulation of fatty acid biosynthetic process (GO:0045723)3.67662726
88positive regulation of coagulation (GO:0050820)3.61462696
89regulation of acute inflammatory response (GO:0002673)3.58954498
90arginine catabolic process (GO:0006527)3.57615999
91reverse cholesterol transport (GO:0043691)3.57605888
92xenobiotic metabolic process (GO:0006805)3.57010129
93heme transport (GO:0015886)3.55649360
94serine family amino acid biosynthetic process (GO:0009070)3.52958136
95opsonization (GO:0008228)3.52170267
96very-low-density lipoprotein particle assembly (GO:0034379)3.50314418
97positive regulation of lipid catabolic process (GO:0050996)3.50245072
98alpha-amino acid catabolic process (GO:1901606)3.48924740
99carnitine metabolic process (GO:0009437)3.46105589
100flavonoid metabolic process (GO:0009812)3.45204979

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.66007282
2EGR1_23403033_ChIP-Seq_LIVER_Mouse6.82774511
3RXR_22158963_ChIP-Seq_LIVER_Mouse6.27072992
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.09989840
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.01719866
6LXR_22158963_ChIP-Seq_LIVER_Mouse4.81906412
7CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.65832791
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.84819907
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.81780584
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.41065441
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.95707154
12HNF4A_19822575_ChIP-Seq_HepG2_Human1.88293416
13FOXA2_19822575_ChIP-Seq_HepG2_Human1.84770053
14TRIM28_21343339_ChIP-Seq_HEK293_Human1.80771308
15TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.61192257
16NFE2_27457419_Chip-Seq_LIVER_Mouse1.55162469
17IRF8_22096565_ChIP-ChIP_GC-B_Human1.48492852
18HTT_18923047_ChIP-ChIP_STHdh_Human1.44651911
19STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.37601688
20ESR1_20079471_ChIP-ChIP_T-47D_Human1.37243981
21SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36891392
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.32849844
23PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26022784
24EZH2_27294783_Chip-Seq_NPCs_Mouse1.23691614
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20583728
26BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19763249
27PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.17926615
28CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.14897353
29TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14545726
30AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.12785944
31FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11167594
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08363981
33HNFA_21074721_ChIP-Seq_CACO-2_Human1.05945085
34GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.05834889
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04247263
36FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.02896806
37SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.00690750
38RXRA_24833708_ChIP-Seq_LIVER_Mouse1.00447201
39GATA6_21074721_ChIP-Seq_CACO-2_Human0.98303396
40PHF8_20622853_ChIP-Seq_HELA_Human0.97333709
41GATA1_22025678_ChIP-Seq_K562_Human0.97129389
42RUNX1_27457419_Chip-Seq_LIVER_Mouse0.97106711
43IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.96608984
44AR_20517297_ChIP-Seq_VCAP_Human0.95502349
45CRX_20693478_ChIP-Seq_RETINA_Mouse0.94837338
46GATA4_25053715_ChIP-Seq_YYC3_Human0.94543707
47CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.92414287
48RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.91455523
49EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.90039069
50MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.89807485
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89502553
52SOX2_20726797_ChIP-Seq_SW620_Human0.89033167
53PU1_27457419_Chip-Seq_LIVER_Mouse0.87976761
54BCAT_22108803_ChIP-Seq_LS180_Human0.86894864
55ER_23166858_ChIP-Seq_MCF-7_Human0.86405811
56OCT4_21477851_ChIP-Seq_ESCs_Mouse0.86015124
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.85942069
58SOX2_21211035_ChIP-Seq_LN229_Human0.85603146
59ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85399990
60NFYA_21822215_ChIP-Seq_K562_Human0.84741874
61ETV1_20927104_ChIP-Seq_GIST48_Human0.83941821
62ESRRB_18555785_Chip-Seq_ESCs_Mouse0.82554487
63KAP1_22055183_ChIP-Seq_ESCs_Mouse0.82313991
64PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.81853019
65RBPJ_21746931_ChIP-Seq_IB4_Human0.81737479
66CBX2_22325352_ChIP-Seq_293T-Rex_Human0.81688211
67EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.81587801
68OCT4_18555785_Chip-Seq_ESCs_Mouse0.81138899
69PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.81137978
70SMAD1_18555785_Chip-Seq_ESCs_Mouse0.80785282
71ESR2_21235772_ChIP-Seq_MCF-7_Human0.80162384
72CEBPB_22108803_ChIP-Seq_LS180_Human0.79339574
73EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.78959525
74STAT3_18555785_Chip-Seq_ESCs_Mouse0.78888095
75ZFX_18555785_Chip-Seq_ESCs_Mouse0.78707349
76P300_18555785_Chip-Seq_ESCs_Mouse0.77619177
77P53_22387025_ChIP-Seq_ESCs_Mouse0.75858726
78KLF4_18555785_Chip-Seq_ESCs_Mouse0.75232917
79FOXA1_25552417_ChIP-Seq_VCAP_Human0.73978309
80SOX2_18555785_Chip-Seq_ESCs_Mouse0.73583679
81P53_21459846_ChIP-Seq_SAOS-2_Human0.73233680
82GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.72706131
83RAD21_21589869_ChIP-Seq_MESCs_Mouse0.71697068
84E2F1_18555785_Chip-Seq_ESCs_Mouse0.71543527
85ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.71498875
86GATA3_21878914_ChIP-Seq_MCF-7_Human0.71002707
87ESR1_15608294_ChIP-ChIP_MCF-7_Human0.69896634
88NCOR_22424771_ChIP-Seq_293T_Human0.68578301
89CTCF_18555785_Chip-Seq_ESCs_Mouse0.68048499
90RAC3_21632823_ChIP-Seq_H3396_Human0.67296240
91PIAS1_25552417_ChIP-Seq_VCAP_Human0.65986886
92OCT4_20526341_ChIP-Seq_ESCs_Human0.65665213
93Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.65660000
94ERA_21632823_ChIP-Seq_H3396_Human0.65631628
95ETV2_25802403_ChIP-Seq_MESCs_Mouse0.65121272
96SUZ12_18555785_Chip-Seq_ESCs_Mouse0.64124669
97ELF1_20517297_ChIP-Seq_JURKAT_Human0.63785843
98TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.63670543
99SRY_22984422_ChIP-ChIP_TESTIS_Rat0.63330643
100FOXH1_21741376_ChIP-Seq_EPCs_Human0.63313969

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.19609725
2MP0005360_urolithiasis6.73257943
3MP0005085_abnormal_gallbladder_physiolo6.16889795
4MP0005365_abnormal_bile_salt5.64346829
5MP0008875_abnormal_xenobiotic_pharmacok5.38517668
6MP0003195_calcinosis5.09224727
7MP0002138_abnormal_hepatobiliary_system5.00860908
8MP0003868_abnormal_feces_composition4.57690488
9MP0009697_abnormal_copulation3.70434057
10MP0003252_abnormal_bile_duct3.40877614
11MP0001666_abnormal_nutrient_absorption3.13291692
12MP0003806_abnormal_nucleotide_metabolis2.88883770
13MP0002876_abnormal_thyroid_physiology2.74459891
14MP0010329_abnormal_lipoprotein_level2.45943005
15MP0009840_abnormal_foam_cell2.24514132
16MP0001764_abnormal_homeostasis2.11735014
17MP0005332_abnormal_amino_acid2.09067976
18MP0004019_abnormal_vitamin_homeostasis2.08444868
19MP0000609_abnormal_liver_physiology1.70709689
20MP0002118_abnormal_lipid_homeostasis1.68775752
21MP0003191_abnormal_cellular_cholesterol1.63281782
22MP0003186_abnormal_redox_activity1.36004755
23MP0002132_abnormal_respiratory_system1.28690296
24MP0005408_hypopigmentation1.17579573
25MP0005319_abnormal_enzyme/_coenzyme1.06570987
26MP0000604_amyloidosis1.04430304
27MP0005584_abnormal_enzyme/coenzyme_acti1.00437023
28MP0009643_abnormal_urine_homeostasis0.99527239
29MP0005376_homeostasis/metabolism_phenot0.97603644
30MP0000598_abnormal_liver_morphology0.96731383
31MP0005187_abnormal_penis_morphology0.96510769
32MP0002090_abnormal_vision0.95913470
33MP0010386_abnormal_urinary_bladder0.94383893
34MP0005636_abnormal_mineral_homeostasis0.89440834
35MP0009763_increased_sensitivity_to0.88183705
36MP0009642_abnormal_blood_homeostasis0.85145468
37MP0009764_decreased_sensitivity_to0.84125261
38MP0005395_other_phenotype0.82891434
39MP0002971_abnormal_brown_adipose0.82799576
40MP0001915_intracranial_hemorrhage0.82662204
41MP0003656_abnormal_erythrocyte_physiolo0.80258978
42MP0003011_delayed_dark_adaptation0.78743479
43MP0002168_other_aberrant_phenotype0.78734750
44MP0008469_abnormal_protein_level0.77721882
45MP0001661_extended_life_span0.77183281
46MP0005058_abnormal_lysosome_morphology0.76397234
47MP0010368_abnormal_lymphatic_system0.75183190
48MP0005464_abnormal_platelet_physiology0.70076617
49MP0006036_abnormal_mitochondrial_physio0.68889415
50MP0005535_abnormal_body_temperature0.65360533
51MP0005164_abnormal_response_to0.63409251
52MP0008874_decreased_physiological_sensi0.62124847
53MP0005167_abnormal_blood-brain_barrier0.61913023
54MP0009785_altered_susceptibility_to0.60679119
55MP0000249_abnormal_blood_vessel0.57223908
56MP0003638_abnormal_response/metabolism_0.57167130
57MP0008872_abnormal_physiological_respon0.55895592
58MP0003075_altered_response_to0.53154168
59MP0002078_abnormal_glucose_homeostasis0.53017566
60MP0005451_abnormal_body_composition0.50785734
61MP0002837_dystrophic_cardiac_calcinosis0.50073622
62MP0009053_abnormal_anal_canal0.48640606
63MP0003690_abnormal_glial_cell0.48535681
64MP0005083_abnormal_biliary_tract0.48243922
65MP0005645_abnormal_hypothalamus_physiol0.47664855
66MP0005166_decreased_susceptibility_to0.47360685
67MP0005266_abnormal_metabolism0.47120889
68MP0001845_abnormal_inflammatory_respons0.45329130
69MP0003879_abnormal_hair_cell0.45201428
70MP0002282_abnormal_trachea_morphology0.42861124
71MP0005334_abnormal_fat_pad0.41968431
72MP0004043_abnormal_pH_regulation0.39471820
73MP0002136_abnormal_kidney_physiology0.38374465
74MP0001986_abnormal_taste_sensitivity0.36403726
75MP0004883_abnormal_blood_vessel0.35784047
76MP0005410_abnormal_fertilization0.34763668
77MP0009115_abnormal_fat_cell0.34667160
78MP0002419_abnormal_innate_immunity0.33965267
79MP0003959_abnormal_lean_body0.31893242
80MP0004036_abnormal_muscle_relaxation0.31890317
81MP0009765_abnormal_xenobiotic_induced0.31269946
82MP0002089_abnormal_postnatal_growth/wei0.30991257
83MP0003953_abnormal_hormone_level0.30745816
84MP0004084_abnormal_cardiac_muscle0.29214327
85MP0003633_abnormal_nervous_system0.29159408
86MP0008873_increased_physiological_sensi0.28728693
87MP0005670_abnormal_white_adipose0.28673350
88MP0003950_abnormal_plasma_membrane0.28659935
89MP0003172_abnormal_lysosome_physiology0.28359045
90MP0004215_abnormal_myocardial_fiber0.28320090
91MP0005025_abnormal_response_to0.27516199
92MP0005084_abnormal_gallbladder_morpholo0.26787936
93MP0005330_cardiomyopathy0.26769671
94MP0003436_decreased_susceptibility_to0.24106954
95MP0004130_abnormal_muscle_cell0.24023708
96MP0003631_nervous_system_phenotype0.23560749
97MP0002970_abnormal_white_adipose0.23036904
98MP0000920_abnormal_myelination0.22927556
99MP0005023_abnormal_wound_healing0.22692813
100MP0005448_abnormal_energy_balance0.21768898

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of monocarboxylic acid metabolism (HP:0010996)9.54913815
2Prolonged partial thromboplastin time (HP:0003645)8.69646118
3Complement deficiency (HP:0004431)7.92824969
4Hypobetalipoproteinemia (HP:0003563)7.22737922
5Abnormality of aromatic amino acid family metabolism (HP:0004338)6.79323910
6Systemic lupus erythematosus (HP:0002725)6.36607446
7Abnormality of complement system (HP:0005339)6.24236776
8Joint hemorrhage (HP:0005261)5.75225692
9Abnormality of pyrimidine metabolism (HP:0004353)5.15962240
10Hyperlipoproteinemia (HP:0010980)5.07049973
11Intrahepatic cholestasis (HP:0001406)4.84304467
12Glomerulonephritis (HP:0000099)4.67992494
13Abnormality of the common coagulation pathway (HP:0010990)4.45401470
14Spontaneous abortion (HP:0005268)4.41969633
15Xanthomatosis (HP:0000991)4.35388503
16Recurrent gram-negative bacterial infections (HP:0005420)4.22025851
17Hypolipoproteinemia (HP:0010981)4.06911919
18Reduced antithrombin III activity (HP:0001976)3.95673570
19Conjugated hyperbilirubinemia (HP:0002908)3.95520289
20Generalized aminoaciduria (HP:0002909)3.62503750
21Abnormality of glutamine family amino acid metabolism (HP:0010902)3.52939324
22Hyperammonemia (HP:0001987)3.47725698
23Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.43669541
24Abnormality of the intrinsic pathway (HP:0010989)3.34903853
25Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.23887828
26Nephritis (HP:0000123)3.09769922
27Gingival bleeding (HP:0000225)3.04760369
28Purpura (HP:0000979)2.91777416
29Hyperglycinemia (HP:0002154)2.88727195
30Hypoalphalipoproteinemia (HP:0003233)2.86815099
31Osteomalacia (HP:0002749)2.80280034
32Fat malabsorption (HP:0002630)2.79779394
33Abnormality of nucleobase metabolism (HP:0010932)2.75820495
34Abnormality of serum amino acid levels (HP:0003112)2.68860892
35Delayed CNS myelination (HP:0002188)2.62454268
36Abnormal respiratory motile cilium physiology (HP:0012261)2.61886610
37Metabolic acidosis (HP:0001942)2.57693330
38Abnormal respiratory motile cilium morphology (HP:0005938)2.55946530
39Abnormal respiratory epithelium morphology (HP:0012253)2.55946530
40Pulmonary embolism (HP:0002204)2.55823794
41Abnormal gallbladder physiology (HP:0012438)2.54551136
42Cholecystitis (HP:0001082)2.54551136
43Dynein arm defect of respiratory motile cilia (HP:0012255)2.53244422
44Absent/shortened dynein arms (HP:0200106)2.53244422
45Abnormality of serine family amino acid metabolism (HP:0010894)2.53086606
46Abnormality of glycine metabolism (HP:0010895)2.53086606
47Hemorrhage of the eye (HP:0011885)2.49887511
48Thrombophlebitis (HP:0004418)2.48375402
49Rhinitis (HP:0012384)2.46183466
50Epidermoid cyst (HP:0200040)2.45620193
51Arthropathy (HP:0003040)2.45522521
52Menorrhagia (HP:0000132)2.39966243
53Abnormality of iron homeostasis (HP:0011031)2.39085392
54Increased serum ferritin (HP:0003281)2.37816891
55Steatorrhea (HP:0002570)2.36980324
56Atrioventricular block (HP:0001678)2.36179215
57Bile duct proliferation (HP:0001408)2.34961979
58Abnormal biliary tract physiology (HP:0012439)2.34961979
59Abnormal ciliary motility (HP:0012262)2.34926913
60Vascular calcification (HP:0004934)2.27957436
61Gangrene (HP:0100758)2.24460156
62Hyperglycinuria (HP:0003108)2.23171469
63Abnormality of transition element cation homeostasis (HP:0011030)2.20841818
64Rickets (HP:0002748)2.15172047
65Hepatocellular carcinoma (HP:0001402)2.10432933
66Abnormality of methionine metabolism (HP:0010901)2.09721830
67Irritability (HP:0000737)2.08307306
68Hyperphosphaturia (HP:0003109)2.07828375
69Abnormality of fatty-acid metabolism (HP:0004359)2.07769605
70Abnormality of the Achilles tendon (HP:0005109)2.06822278
71Glycosuria (HP:0003076)2.03432065
72Abnormality of urine glucose concentration (HP:0011016)2.03432065
73Deep venous thrombosis (HP:0002625)10.5418213
74Fair hair (HP:0002286)1.98795250
75Cardiovascular calcification (HP:0011915)1.95665875
76Ketosis (HP:0001946)1.93275886
77Alkalosis (HP:0001948)1.93264687
78Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.92068963
79Abnormality of aspartate family amino acid metabolism (HP:0010899)1.91210835
80Hyperbilirubinemia (HP:0002904)1.90339329
81Mitral stenosis (HP:0001718)1.90124267
82Chronic bronchitis (HP:0004469)1.86406018
83Elevated alkaline phosphatase (HP:0003155)1.83099608
84Hypercholesterolemia (HP:0003124)1.79055456
85Lethargy (HP:0001254)1.78292236
86Myocardial infarction (HP:0001658)1.77402973
87Abnormal enzyme/coenzyme activity (HP:0012379)1.74804868
88Increased serum pyruvate (HP:0003542)1.74704989
89Retinal atrophy (HP:0001105)1.73287997
90Abnormality of alkaline phosphatase activity (HP:0004379)1.73161822
91Vomiting (HP:0002013)1.73135469
92Abnormal pupillary function (HP:0007686)1.72513276
93Cerebral edema (HP:0002181)1.70177142
94Pancreatitis (HP:0001733)1.70130575
95Proximal tubulopathy (HP:0000114)1.67613235
96Cholelithiasis (HP:0001081)1.67507531
97Abnormality of purine metabolism (HP:0004352)1.65755529
98Joint swelling (HP:0001386)1.64611729
99Abnormal urine phosphate concentration (HP:0012599)1.63329794
100Abnormal gallbladder morphology (HP:0012437)1.61980160

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK154.17700495
2ERN13.84529927
3PIK3CG2.72948447
4ACVR1B2.70763528
5FGFR42.58202720
6TBK12.51490162
7BCKDK2.40301622
8MUSK2.13339391
9MAPKAPK32.00730344
10NEK91.93401944
11PRKACG1.91457915
12PINK11.90372786
13TYK21.87826427
14MAP3K31.83784032
15BLK1.81902086
16MAP3K121.81304474
17CAMKK21.77426237
18TIE11.74021606
19PDK21.72860003
20MYLK1.63083372
21PRKAA21.56454080
22GRK11.55096946
23PIK3CA1.51560345
24TAOK31.44401265
25ABL21.43506033
26PRKCG1.41927902
27IRAK31.41311442
28ADRBK21.38588068
29EPHA31.34430406
30MAP3K51.18618094
31PKN21.17952385
32PRKG11.15354152
33FRK1.13489296
34FGFR31.10441727
35ZAP701.10057961
36RIPK11.07609532
37PDPK11.06674398
38CDC42BPA1.05394494
39WNK31.05211061
40INSRR1.04222044
41FLT31.03886343
42PRKACA1.03572112
43PRKCE1.01574441
44MAP2K41.01248186
45MAP2K30.95111179
46CAMKK10.90848736
47IGF1R0.90400735
48MST40.79336708
49PRKCA0.77969191
50MAP4K20.76534046
51SGK10.74339079
52GRK60.74220213
53MAP3K60.69921094
54BMPR20.69009332
55PRKCZ0.68966256
56JAK10.68946033
57MAPK110.68644784
58SCYL20.67563830
59PDK10.66060608
60MAP3K20.65051574
61EPHA40.64726125
62PRKACB0.62679018
63DAPK30.62136537
64STK38L0.61746247
65NTRK30.61456101
66MST1R0.60352245
67PIM20.60016084
68TNK20.59977178
69CSNK1D0.59520958
70TGFBR20.59375113
71PRKCB0.59364153
72MAPK120.57627262
73STK380.57334525
74ERBB20.56735683
75RPS6KA30.55563741
76TRPM70.55425311
77CAMK2G0.54765532
78EIF2AK30.54758038
79TAOK20.53784833
80PRKAA10.53046637
81ARAF0.52620776
82BRSK20.51919889
83IKBKB0.50549476
84ERBB40.49109869
85JAK20.47982077
86CSK0.46596611
87MAPK40.46452689
88STK160.45907627
89MAP3K70.45428134
90EPHB10.44222845
91MET0.43668031
92FER0.43341647
93CSNK2A20.42653247
94OBSCN0.42469111
95JAK30.41333600
96MAP2K60.41178880
97EIF2AK10.39148603
98IKBKE0.38727210
99TAOK10.38294588
100PRKD10.37805219

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.66558451
2Complement and coagulation cascades_Homo sapiens_hsa046104.28641207
3Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.38421382
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.26552439
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.06675136
6Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.01606477
7Retinol metabolism_Homo sapiens_hsa008302.95064096
8Steroid hormone biosynthesis_Homo sapiens_hsa001402.90437705
9Caffeine metabolism_Homo sapiens_hsa002322.89341147
10Phenylalanine metabolism_Homo sapiens_hsa003602.88633992
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.87920097
12Chemical carcinogenesis_Homo sapiens_hsa052042.85193889
13Arginine biosynthesis_Homo sapiens_hsa002202.79962042
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.67526343
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.43913147
16Drug metabolism - other enzymes_Homo sapiens_hsa009832.26452973
17Tyrosine metabolism_Homo sapiens_hsa003502.10948604
18Fatty acid degradation_Homo sapiens_hsa000712.03021909
19Histidine metabolism_Homo sapiens_hsa003401.96112272
20Bile secretion_Homo sapiens_hsa049761.85714447
21Linoleic acid metabolism_Homo sapiens_hsa005911.77726861
22Peroxisome_Homo sapiens_hsa041461.77462602
23PPAR signaling pathway_Homo sapiens_hsa033201.63865399
24Butanoate metabolism_Homo sapiens_hsa006501.62833578
25Tryptophan metabolism_Homo sapiens_hsa003801.61805600
26Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.59099868
27beta-Alanine metabolism_Homo sapiens_hsa004101.49119276
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.48173175
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.46811265
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.43268847
31Starch and sucrose metabolism_Homo sapiens_hsa005001.40915578
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.35037385
33Staphylococcus aureus infection_Homo sapiens_hsa051501.30646762
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.30422990
35Sulfur metabolism_Homo sapiens_hsa009201.27544481
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.26333518
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.23522268
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.22015420
39Arachidonic acid metabolism_Homo sapiens_hsa005901.19741247
40Arginine and proline metabolism_Homo sapiens_hsa003301.15582227
41Sulfur relay system_Homo sapiens_hsa041221.15057205
42Biosynthesis of amino acids_Homo sapiens_hsa012301.12726694
43Prion diseases_Homo sapiens_hsa050201.06643980
44Pyruvate metabolism_Homo sapiens_hsa006201.04078580
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.03206199
46Carbon metabolism_Homo sapiens_hsa012000.88390188
47Fat digestion and absorption_Homo sapiens_hsa049750.87177850
48Propanoate metabolism_Homo sapiens_hsa006400.86316375
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83772781
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78866573
51Vitamin B6 metabolism_Homo sapiens_hsa007500.76793202
52Fatty acid metabolism_Homo sapiens_hsa012120.70658050
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.63291440
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61959909
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.61267924
56Fatty acid elongation_Homo sapiens_hsa000620.59218377
57ABC transporters_Homo sapiens_hsa020100.58514445
58One carbon pool by folate_Homo sapiens_hsa006700.57989708
59Glutathione metabolism_Homo sapiens_hsa004800.52406179
60Fructose and mannose metabolism_Homo sapiens_hsa000510.50217426
61Glycosaminoglycan degradation_Homo sapiens_hsa005310.49746282
62Metabolic pathways_Homo sapiens_hsa011000.48128080
63Pertussis_Homo sapiens_hsa051330.41520065
64Glycerolipid metabolism_Homo sapiens_hsa005610.40057039
65Other glycan degradation_Homo sapiens_hsa005110.34478739
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34076859
67Lysine degradation_Homo sapiens_hsa003100.33886458
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32628705
69Vitamin digestion and absorption_Homo sapiens_hsa049770.26031964
70Steroid biosynthesis_Homo sapiens_hsa001000.24946397
71Pentose phosphate pathway_Homo sapiens_hsa000300.23942501
72Insulin resistance_Homo sapiens_hsa049310.19580909
73Mineral absorption_Homo sapiens_hsa049780.15050267
74Renin-angiotensin system_Homo sapiens_hsa046140.11512973
75Glucagon signaling pathway_Homo sapiens_hsa049220.07985427
76Systemic lupus erythematosus_Homo sapiens_hsa053220.07914546
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.07439883
78Sphingolipid metabolism_Homo sapiens_hsa006000.06709363
79Folate biosynthesis_Homo sapiens_hsa007900.05030436
80Amoebiasis_Homo sapiens_hsa051460.04327604
81Ovarian steroidogenesis_Homo sapiens_hsa049130.04155847
82Fatty acid biosynthesis_Homo sapiens_hsa000610.04136234
83Galactose metabolism_Homo sapiens_hsa000520.02318900
84Nitrogen metabolism_Homo sapiens_hsa009100.01671659
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.01477404
86Serotonergic synapse_Homo sapiens_hsa047260.01100817
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060-0.1755607
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.1746966
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1709462
90Circadian rhythm_Homo sapiens_hsa04710-0.1507224
91N-Glycan biosynthesis_Homo sapiens_hsa00510-0.1222536
92AMPK signaling pathway_Homo sapiens_hsa04152-0.1180902
93Lysosome_Homo sapiens_hsa04142-0.1092260
94Ether lipid metabolism_Homo sapiens_hsa00565-0.0988513
95African trypanosomiasis_Homo sapiens_hsa05143-0.0928243
96Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0539228
97Selenocompound metabolism_Homo sapiens_hsa00450-0.0397381
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0250460
99Adipocytokine signaling pathway_Homo sapiens_hsa04920-0.0189332
100Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0012818

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