CES4A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They also participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene, also called CES6, encodes a secreted enzyme, and may play a role in the detoxification of drugs and xenobiotics in neural and other tissues of the body and in the cerebrospinal fluid. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature and/or biological validity of some variants have not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)8.99589206
2hair cycle (GO:0042633)8.23432814
3molting cycle (GO:0042303)8.23432814
4cilium or flagellum-dependent cell motility (GO:0001539)7.79974798
5cilium movement (GO:0003341)7.10537705
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.86917663
7keratinization (GO:0031424)6.71988405
8epithelial cilium movement (GO:0003351)6.29301653
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.81005058
10L-phenylalanine catabolic process (GO:0006559)5.81005058
11motile cilium assembly (GO:0044458)5.79090430
12axoneme assembly (GO:0035082)5.69085292
13aromatic amino acid family catabolic process (GO:0009074)5.68913966
14indole-containing compound catabolic process (GO:0042436)5.58742930
15indolalkylamine catabolic process (GO:0046218)5.58742930
16tryptophan catabolic process (GO:0006569)5.58742930
17L-phenylalanine metabolic process (GO:0006558)5.47293196
18erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.47293196
19kynurenine metabolic process (GO:0070189)5.33887868
20tryptophan metabolic process (GO:0006568)5.17555716
21gap junction assembly (GO:0016264)5.08489618
22bile acid biosynthetic process (GO:0006699)5.05749737
23complement activation, alternative pathway (GO:0006957)5.02473935
24regulation of protein activation cascade (GO:2000257)4.95024668
25fibrinolysis (GO:0042730)4.82094432
26regulation of fibrinolysis (GO:0051917)4.79188476
27regulation of complement activation (GO:0030449)4.73517507
28urea metabolic process (GO:0019627)4.68175362
29urea cycle (GO:0000050)4.68175362
30fatty acid elongation (GO:0030497)4.65204791
31desmosome organization (GO:0002934)4.60752956
32glyoxylate metabolic process (GO:0046487)4.51076175
33protein carboxylation (GO:0018214)4.49990377
34peptidyl-glutamic acid carboxylation (GO:0017187)4.49990377
35triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.49468664
36synaptic vesicle maturation (GO:0016188)4.49207705
37regulation of cilium movement (GO:0003352)4.48290734
38establishment of skin barrier (GO:0061436)4.47227909
39gamma-aminobutyric acid transport (GO:0015812)4.39047741
40bile acid metabolic process (GO:0008206)4.31764614
41nitrogen cycle metabolic process (GO:0071941)4.23912426
42negative regulation of fibrinolysis (GO:0051918)4.23349430
43membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.17251861
44alpha-linolenic acid metabolic process (GO:0036109)4.16837812
45regulation of short-term neuronal synaptic plasticity (GO:0048172)4.14515792
46fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.13661554
47skin morphogenesis (GO:0043589)4.13057963
48high-density lipoprotein particle remodeling (GO:0034375)4.10275461
49glutamate secretion (GO:0014047)4.08722644
50phospholipid efflux (GO:0033700)4.05971311
51aromatic amino acid family metabolic process (GO:0009072)4.03298460
52synaptic vesicle docking involved in exocytosis (GO:0016081)3.99646399
53neurotransmitter secretion (GO:0007269)3.95743003
54intermediate filament organization (GO:0045109)3.93417343
55hemidesmosome assembly (GO:0031581)3.92187158
56negative regulation of synaptic transmission, GABAergic (GO:0032229)3.91992120
57cysteine metabolic process (GO:0006534)3.90559147
58protein localization to cilium (GO:0061512)3.90193333
59imidazole-containing compound metabolic process (GO:0052803)3.89363654
60bundle of His cell to Purkinje myocyte communication (GO:0086069)3.88218818
61homocysteine metabolic process (GO:0050667)3.84133292
62sulfur amino acid catabolic process (GO:0000098)3.83643894
63bile acid and bile salt transport (GO:0015721)3.83434478
64amine catabolic process (GO:0009310)3.82827465
65cellular biogenic amine catabolic process (GO:0042402)3.82827465
66tyrosine metabolic process (GO:0006570)3.81542380
67regulation of triglyceride catabolic process (GO:0010896)3.80979874
68synaptic vesicle exocytosis (GO:0016079)3.78031364
69indolalkylamine metabolic process (GO:0006586)3.77509002
70blood coagulation, intrinsic pathway (GO:0007597)3.76244089
71regulation of water loss via skin (GO:0033561)3.76115610
72reverse cholesterol transport (GO:0043691)3.68230909
73coenzyme catabolic process (GO:0009109)3.67219356
74central nervous system myelination (GO:0022010)3.64321301
75axon ensheathment in central nervous system (GO:0032291)3.64321301
76dicarboxylic acid biosynthetic process (GO:0043650)3.62321620
77acetyl-CoA metabolic process (GO:0006084)3.60106338
78triglyceride homeostasis (GO:0070328)3.59864419
79acylglycerol homeostasis (GO:0055090)3.59864419
80regulation of microtubule-based movement (GO:0060632)3.59049624
81positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.57874727
82protein activation cascade (GO:0072376)3.54278779
83linoleic acid metabolic process (GO:0043651)3.53776320
84complement activation (GO:0006956)3.53685830
85plasma lipoprotein particle remodeling (GO:0034369)3.53563176
86protein-lipid complex remodeling (GO:0034368)3.53563176
87macromolecular complex remodeling (GO:0034367)3.53563176
88fatty-acyl-CoA biosynthetic process (GO:0046949)3.53463034
89plasma lipoprotein particle clearance (GO:0034381)3.53147072
90ionotropic glutamate receptor signaling pathway (GO:0035235)3.52368156
91microtubule bundle formation (GO:0001578)3.52229903
92very long-chain fatty acid metabolic process (GO:0000038)3.51886021
93vocalization behavior (GO:0071625)3.51491019
94cholesterol efflux (GO:0033344)3.49685288
95alpha-amino acid catabolic process (GO:1901606)3.49492780
96cellular modified amino acid catabolic process (GO:0042219)3.41298179
97negative regulation of hemostasis (GO:1900047)3.38257468
98negative regulation of blood coagulation (GO:0030195)3.38257468
99cytolysis (GO:0019835)3.37781825
100positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.37000016
101cilium organization (GO:0044782)3.35411008
102long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.35097461
103regulation of synapse structural plasticity (GO:0051823)3.35016610
104regulation of neurotransmitter levels (GO:0001505)3.34174781
105amino-acid betaine metabolic process (GO:0006577)3.33343399
106serine family amino acid catabolic process (GO:0009071)3.33159018
107left/right pattern formation (GO:0060972)3.32882311
108synaptic transmission, glutamatergic (GO:0035249)3.31940784
109benzene-containing compound metabolic process (GO:0042537)3.30802356
110lysine catabolic process (GO:0006554)3.28703378
111lysine metabolic process (GO:0006553)3.28703378
112transmission of nerve impulse (GO:0019226)3.28204780
113positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.28170607
114cilium assembly (GO:0042384)3.26677261
115arginine metabolic process (GO:0006525)3.25150451
116complement activation, classical pathway (GO:0006958)3.24650517
117neuronal action potential propagation (GO:0019227)3.23041230
118regulation of cholesterol esterification (GO:0010872)3.22869437
119glutamate metabolic process (GO:0006536)3.21864772
120purine ribonucleotide transport (GO:0015868)3.20652742
121drug catabolic process (GO:0042737)3.17850587
122cellular amino acid catabolic process (GO:0009063)3.16235202
123negative regulation of sterol transport (GO:0032372)3.16088131
124negative regulation of cholesterol transport (GO:0032375)3.16088131
125cellular glucuronidation (GO:0052695)3.14706660
126phospholipid homeostasis (GO:0055091)3.14706223
127purine nucleotide transport (GO:0015865)3.14322127
128exogenous drug catabolic process (GO:0042738)3.13837041
129neurotransmitter transport (GO:0006836)3.12576044
130cofactor catabolic process (GO:0051187)3.11122097
131peptide cross-linking (GO:0018149)3.10962536
132negative regulation of wound healing (GO:0061045)3.09043815
133negative regulation of lipase activity (GO:0060192)3.08096610
134glutamate receptor signaling pathway (GO:0007215)3.07508992
135plasma lipoprotein particle assembly (GO:0034377)3.07384248
136negative regulation of coagulation (GO:0050819)3.06528999
137ventricular system development (GO:0021591)3.04319171
138one-carbon compound transport (GO:0019755)2.98546244
139regulation of synaptic vesicle exocytosis (GO:2000300)2.93141335
140auditory behavior (GO:0031223)2.91485210
141neuron-neuron synaptic transmission (GO:0007270)2.90620997
142regulation of synaptic vesicle transport (GO:1902803)2.89366159
143membrane depolarization during action potential (GO:0086010)2.88074183
144neuron cell-cell adhesion (GO:0007158)2.86691839
145retinal cone cell development (GO:0046549)2.84958808
146intraciliary transport (GO:0042073)2.84239749
147proline transport (GO:0015824)2.81408456
148negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.80488860
149primary alcohol catabolic process (GO:0034310)2.77457539
150dendritic spine morphogenesis (GO:0060997)2.77397407
151regulation of voltage-gated calcium channel activity (GO:1901385)2.74077537
152negative regulation of inclusion body assembly (GO:0090084)2.72964901
153protein localization to synapse (GO:0035418)2.72836986
154neurotransmitter catabolic process (GO:0042135)2.72759435
155cilium morphogenesis (GO:0060271)2.71883215
156regulation of neuronal synaptic plasticity (GO:0048168)2.71076375
157regulation of vesicle fusion (GO:0031338)2.70418366
158left/right axis specification (GO:0070986)2.70032242
159neuronal action potential (GO:0019228)2.68883502
160ethanol metabolic process (GO:0006067)2.67506821
161locomotory exploration behavior (GO:0035641)2.66485613
162detection of calcium ion (GO:0005513)2.66346377
163regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.65772224
164cellular component assembly involved in morphogenesis (GO:0010927)2.64216446
165primary amino compound metabolic process (GO:1901160)2.63946844
166regulation of long-term neuronal synaptic plasticity (GO:0048169)2.63475051
167positive regulation of membrane potential (GO:0045838)2.62572067
168regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.60048797
169regulation of germinal center formation (GO:0002634)2.59096522
170cochlea development (GO:0090102)2.57846759
171regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.57375842
172serotonin metabolic process (GO:0042428)2.56903749
173phosphorelay signal transduction system (GO:0000160)2.56171384
174response to amphetamine (GO:0001975)2.55732231
175vitamin transmembrane transport (GO:0035461)2.55555107
176cellular potassium ion homeostasis (GO:0030007)2.53353013
177exploration behavior (GO:0035640)2.52509144
178postsynaptic membrane organization (GO:0001941)2.52425549
179potassium ion transmembrane transport (GO:0071805)2.52385620
180cellular potassium ion transport (GO:0071804)2.52385620
181urinary tract smooth muscle contraction (GO:0014848)2.52154564
182glycosphingolipid biosynthetic process (GO:0006688)2.51753655
183neurotransmitter metabolic process (GO:0042133)2.51443119
184lung epithelium development (GO:0060428)2.51184740
185neuromuscular process controlling posture (GO:0050884)2.50601311
186cellular ketone body metabolic process (GO:0046950)2.49754622
187positive regulation of vesicle fusion (GO:0031340)2.48683367
188negative regulation of cytosolic calcium ion concentration (GO:0051481)2.48569759
189synaptic transmission (GO:0007268)2.48347866
190regulation of neurotransmitter transport (GO:0051588)2.44922667
191neurotransmitter-gated ion channel clustering (GO:0072578)2.44662379
192potassium ion homeostasis (GO:0055075)2.43767359
193behavioral response to nicotine (GO:0035095)2.43681025
194cerebellar granule cell differentiation (GO:0021707)2.42387274
195membrane depolarization (GO:0051899)2.42368447
196regulation of neurotransmitter secretion (GO:0046928)2.41593433
197regulation of glutamate receptor signaling pathway (GO:1900449)2.41517575
198positive regulation of neurotransmitter transport (GO:0051590)2.41273937

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.49936953
2TP63_17297297_ChIP-ChIP_HaCaT_Human6.71217508
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.08257027
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.46433822
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.41280081
6LXR_22158963_ChIP-Seq_LIVER_Mouse4.18337805
7EZH2_22144423_ChIP-Seq_EOC_Human3.89276992
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.35693070
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.11742984
10GATA1_22025678_ChIP-Seq_K562_Human3.08034226
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.05210609
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.67509828
13REST_21632747_ChIP-Seq_MESCs_Mouse2.47173542
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.46842163
15* CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.28587448
16GBX2_23144817_ChIP-Seq_PC3_Human2.26248168
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.07042816
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.86806979
19IRF8_22096565_ChIP-ChIP_GC-B_Human1.82149296
20JARID2_20064375_ChIP-Seq_MESCs_Mouse1.82130503
21TRIM28_21343339_ChIP-Seq_HEK293_Human1.81212556
22ZNF274_21170338_ChIP-Seq_K562_Hela1.80896712
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.80053269
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79405061
25VDR_22108803_ChIP-Seq_LS180_Human1.79276335
26REST_18959480_ChIP-ChIP_MESCs_Mouse1.76025022
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.72228586
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72095228
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.69978660
30EZH2_27304074_Chip-Seq_ESCs_Mouse1.65113600
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.61933606
32P63_26484246_Chip-Seq_KERATINOCYTES_Human1.60369816
33PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.56164547
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.52242684
35CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.49583014
36TAF15_26573619_Chip-Seq_HEK293_Human1.43416118
37EZH2_18974828_ChIP-Seq_MESCs_Mouse1.41647314
38RNF2_18974828_ChIP-Seq_MESCs_Mouse1.41647314
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.39312856
40SMAD4_21799915_ChIP-Seq_A2780_Human1.38600073
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.38019784
42IGF1R_20145208_ChIP-Seq_DFB_Human1.37983895
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37178893
44PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36841901
45AR_21572438_ChIP-Seq_LNCaP_Human1.31195818
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30921603
47TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.30131624
48RARB_27405468_Chip-Seq_BRAIN_Mouse1.28630010
49THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27086347
50P300_19829295_ChIP-Seq_ESCs_Human1.25900863
51BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.25676005
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25286817
53CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.25245621
54NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24479982
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24323333
56CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.23457388
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22673567
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.22065949
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21286647
60STAT3_23295773_ChIP-Seq_U87_Human1.19807292
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.18120013
62ESR1_21235772_ChIP-Seq_MCF-7_Human1.17214823
63RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.16561227
64AR_25329375_ChIP-Seq_VCAP_Human1.16551821
65PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.15177882
66TCF4_23295773_ChIP-Seq_U87_Human1.14911796
67FLI1_27457419_Chip-Seq_LIVER_Mouse1.14668272
68CLOCK_20551151_ChIP-Seq_293T_Human1.14653550
69RNF2_27304074_Chip-Seq_NSC_Mouse1.14256925
70TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.13205318
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13127396
72ER_23166858_ChIP-Seq_MCF-7_Human1.13094288
73HTT_18923047_ChIP-ChIP_STHdh_Human1.07570573
74PRDM14_20953172_ChIP-Seq_ESCs_Human1.07110900
75CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05469965
76MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05441877
77FUS_26573619_Chip-Seq_HEK293_Human1.04309091
78PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03781075
79RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03353262
80SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03254453
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02863795
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02863795
83CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02422206
84RUNX2_22187159_ChIP-Seq_PCA_Human1.01920047
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01282320
86CBP_20019798_ChIP-Seq_JUKART_Human1.01282320
87TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01063983
88SOX2_21211035_ChIP-Seq_LN229_Gbm1.00304216
89TCF4_22108803_ChIP-Seq_LS180_Human0.99424129
90FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99188791
91EGR1_19032775_ChIP-ChIP_M12_Human0.99102782
92FOXA2_19822575_ChIP-Seq_HepG2_Human0.99072357
93STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.98571746
94RING1B_27294783_Chip-Seq_ESCs_Mouse0.95694103
95TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94646713
96SMAD4_21741376_ChIP-Seq_EPCs_Human0.94591142
97BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94425453
98SOX9_24532713_ChIP-Seq_HFSC_Mouse0.94192642
99ETV2_25802403_ChIP-Seq_MESCs_Mouse0.93530630
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93528362
101ARNT_22903824_ChIP-Seq_MCF-7_Human0.93097560
102MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.92082039
103TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91787835
104SUZ12_27294783_Chip-Seq_ESCs_Mouse0.91380280
105FOXA1_27270436_Chip-Seq_PROSTATE_Human0.91198697
106FOXA1_25329375_ChIP-Seq_VCAP_Human0.91198697
107FOXO3_23340844_ChIP-Seq_DLD1_Human0.91049781
108NANOG_19829295_ChIP-Seq_ESCs_Human0.90933190
109SOX2_19829295_ChIP-Seq_ESCs_Human0.90933190
110Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.90909432
111AR_19668381_ChIP-Seq_PC3_Human0.90718430
112CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.90700146
113SMAD3_21741376_ChIP-Seq_ESCs_Human0.90238164
114SMAD3_21741376_ChIP-Seq_HESCs_Human0.90137862
115NANOG_18555785_Chip-Seq_ESCs_Mouse0.89980999
116P53_22387025_ChIP-Seq_ESCs_Mouse0.89833708
117SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.89499222
118AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.89380831
119UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89273010
120SMAD4_21741376_ChIP-Seq_HESCs_Human0.88715249
121EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.87751727
122GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86722858
123SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.86690277
124EED_16625203_ChIP-ChIP_MESCs_Mouse0.86165187
125CTCF_27219007_Chip-Seq_Bcells_Human0.84935360
126ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.84934223
127SOX2_20726797_ChIP-Seq_SW620_Human0.84736061
128RXRA_24833708_ChIP-Seq_LIVER_Mouse0.84525721
129SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.84200076
130LXR_22292898_ChIP-Seq_THP-1_Human0.83917896
131EZH2_27294783_Chip-Seq_ESCs_Mouse0.83495535
132BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.83120536
133RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.83026842
134PIAS1_25552417_ChIP-Seq_VCAP_Human0.82316432
135HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.81452999
136ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.81112620
137GATA4_25053715_ChIP-Seq_YYC3_Human0.80903962
138GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.79888674
139CJUN_26792858_Chip-Seq_BT549_Human0.79767673
140JARID2_20075857_ChIP-Seq_MESCs_Mouse0.78542299
141SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.78368579
142SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.77829177
143TP63_23658742_ChIP-Seq_EP156T_Human0.77636695
144MTF2_20144788_ChIP-Seq_MESCs_Mouse0.77521048
145ZNF217_24962896_ChIP-Seq_MCF-7_Human0.77065759
146ERG_21242973_ChIP-ChIP_JURKAT_Human0.76717822
147TAF2_19829295_ChIP-Seq_ESCs_Human0.76596292
148RARG_19884340_ChIP-ChIP_MEFs_Mouse0.75018292
149SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.74033898
150SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.74033898
151BCAT_22108803_ChIP-Seq_LS180_Human0.73922280
152TP53_20018659_ChIP-ChIP_R1E_Mouse0.72902294
153CEBPB_22108803_ChIP-Seq_LS180_Human0.72251480
154P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.71634243
155CSB_26484114_Chip-Seq_FIBROBLAST_Human0.70911117
156SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.70505655
157SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.69723836
158DNAJC2_21179169_ChIP-ChIP_NT2_Human0.69270983
159TP53_18474530_ChIP-ChIP_U2OS_Human0.69223181
160E2F1_20622854_ChIP-Seq_HELA_Human0.68911156
161TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.68883607
162RACK7_27058665_Chip-Seq_MCF-7_Human0.68836162
163DROSHA_22980978_ChIP-Seq_HELA_Human0.68550699
164GATA6_21074721_ChIP-Seq_CACO-2_Human0.67960750
165RNF2_27304074_Chip-Seq_ESCs_Mouse0.67921945
166TP63_22573176_ChIP-Seq_HFKS_Human0.67174736
167SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.66833654
168RXR_22108803_ChIP-Seq_LS180_Human0.65538203
169CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.64945903
170TBX20_22080862_ChIP-Seq_HEART_Mouse0.64189836
171TBX20_22328084_ChIP-Seq_HEART_Mouse0.64189836
172CTCF_20526341_ChIP-Seq_ESCs_Human0.63713520
173RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63449100
174HNF4A_19822575_ChIP-Seq_HepG2_Human0.63410811
175GATA2_19941826_ChIP-Seq_K562_Human0.63049627
176AHR_22903824_ChIP-Seq_MCF-7_Human0.62979514
177JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.62564992
178AUTS2_25519132_ChIP-Seq_293T-REX_Human0.62277813
179GATA3_24758297_ChIP-Seq_MCF-7_Human0.62114234

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology5.91606500
2MP0002139_abnormal_hepatobiliary_system5.56171631
3MP0005360_urolithiasis5.14659745
4MP0005085_abnormal_gallbladder_physiolo4.84351119
5MP0002796_impaired_skin_barrier4.76435212
6MP0005365_abnormal_bile_salt4.40025920
7MP0004859_abnormal_synaptic_plasticity3.75610778
8MP0003880_abnormal_central_pattern3.56288825
9MP0005275_abnormal_skin_tensile3.29352402
10MP0002653_abnormal_ependyma_morphology3.27475509
11MP0004381_abnormal_hair_follicle3.16402714
12MP0000467_abnormal_esophagus_morphology3.06755463
13MP0009745_abnormal_behavioral_response3.01036186
14MP0003252_abnormal_bile_duct2.96149747
15MP0008875_abnormal_xenobiotic_pharmacok2.88362940
16MP0002064_seizures2.80948047
17MP0003635_abnormal_synaptic_transmissio2.77551600
18MP0009046_muscle_twitch2.71501557
19MP0001968_abnormal_touch/_nociception2.68891586
20MP0004270_analgesia2.66649618
21MP0005501_abnormal_skin_physiology2.64915510
22MP0002272_abnormal_nervous_system2.56803085
23MP0001984_abnormal_olfaction2.44753571
24MP0001486_abnormal_startle_reflex2.44617677
25MP0003705_abnormal_hypodermis_morpholog2.39441820
26MP0010329_abnormal_lipoprotein_level2.35175830
27MP0002063_abnormal_learning/memory/cond2.34753092
28MP0002734_abnormal_mechanical_nocicepti2.34588731
29MP0002572_abnormal_emotion/affect_behav2.31018311
30MP0001501_abnormal_sleep_pattern2.27963291
31MP0002735_abnormal_chemical_nociception2.23371009
32MP0002254_reproductive_system_inflammat2.19030525
33MP0002060_abnormal_skin_morphology2.12557000
34MP0005423_abnormal_somatic_nervous2.09916125
35MP0003191_abnormal_cellular_cholesterol2.09581179
36MP0001216_abnormal_epidermal_layer2.03392838
37MP0000647_abnormal_sebaceous_gland2.01503905
38MP0010234_abnormal_vibrissa_follicle2.01097602
39MP0000383_abnormal_hair_follicle2.00040165
40MP0003787_abnormal_imprinting1.99109661
41MP0009780_abnormal_chondrocyte_physiolo1.93630742
42MP0001970_abnormal_pain_threshold1.90990439
43MP0002736_abnormal_nociception_after1.83658917
44MP0005451_abnormal_body_composition1.83526539
45MP0003806_abnormal_nucleotide_metabolis1.82477336
46MP0001666_abnormal_nutrient_absorption1.80106537
47MP0005551_abnormal_eye_electrophysiolog1.79710788
48MP0004947_skin_inflammation1.78488501
49MP0000377_abnormal_hair_follicle1.77198474
50MP0010678_abnormal_skin_adnexa1.73838858
51MP0004019_abnormal_vitamin_homeostasis1.73040624
52MP0004133_heterotaxia1.72963689
53MP0002098_abnormal_vibrissa_morphology1.72735868
54MP0005083_abnormal_biliary_tract1.72455712
55MP0004043_abnormal_pH_regulation1.71376480
56MP0010771_integument_phenotype1.70787572
57MP0003453_abnormal_keratinocyte_physiol1.70613073
58MP0005646_abnormal_pituitary_gland1.69185830
59MP0002638_abnormal_pupillary_reflex1.68895698
60MP0009840_abnormal_foam_cell1.68768879
61MP0001905_abnormal_dopamine_level1.65686246
62MP0003195_calcinosis1.65020755
63MP0002557_abnormal_social/conspecific_i1.63687684
64MP0008877_abnormal_DNA_methylation1.63122783
65MP0005332_abnormal_amino_acid1.61751813
66MP0002733_abnormal_thermal_nociception1.59967108
67MP0001502_abnormal_circadian_rhythm1.57071406
68MP0000427_abnormal_hair_cycle1.55608660
69MP0000762_abnormal_tongue_morphology1.53678696
70MP0003868_abnormal_feces_composition1.52873883
71MP0002277_abnormal_respiratory_mucosa1.52577823
72MP0002067_abnormal_sensory_capabilities1.52568685
73MP0004142_abnormal_muscle_tone1.51665943
74MP0002909_abnormal_adrenal_gland1.50720723
75MP0008872_abnormal_physiological_respon1.43406528
76MP0000609_abnormal_liver_physiology1.41896736
77MP0002138_abnormal_hepatobiliary_system1.41212202
78MP0001986_abnormal_taste_sensitivity1.39104771
79MP0002118_abnormal_lipid_homeostasis1.38812930
80MP0005409_darkened_coat_color1.36403733
81MP0005386_behavior/neurological_phenoty1.33871750
82MP0004924_abnormal_behavior1.33871750
83MP0001440_abnormal_grooming_behavior1.33225727
84MP0001485_abnormal_pinna_reflex1.32918947
85MP0003633_abnormal_nervous_system1.30894852
86MP0002822_catalepsy1.30474946
87MP0008569_lethality_at_weaning1.29831917
88MP0005645_abnormal_hypothalamus_physiol1.27900825
89MP0003879_abnormal_hair_cell1.26046863
90MP0006054_spinal_hemorrhage1.21346583
91MP0000604_amyloidosis1.20959804
92MP0004742_abnormal_vestibular_system1.20752224
93MP0002229_neurodegeneration1.20110376
94MP0000569_abnormal_digit_pigmentation1.19598732
95MP0006276_abnormal_autonomic_nervous1.18149050
96MP0005319_abnormal_enzyme/_coenzyme1.13046647
97MP0003724_increased_susceptibility_to1.11617303
98MP0003631_nervous_system_phenotype1.11548418
99MP0001243_abnormal_dermal_layer1.11197833
100MP0002102_abnormal_ear_morphology1.11120564
101MP0003329_amyloid_beta_deposits1.11057285
102MP0002066_abnormal_motor_capabilities/c1.10815143
103MP0002882_abnormal_neuron_morphology1.10259210
104MP0000955_abnormal_spinal_cord1.09371225
105MP0001963_abnormal_hearing_physiology1.07307992
106MP0010386_abnormal_urinary_bladder1.06631356
107MP0000778_abnormal_nervous_system1.05963697
108MP0009764_decreased_sensitivity_to1.05264856
109MP0009931_abnormal_skin_appearance1.02483733
110MP0000367_abnormal_coat/_hair1.01434307
111MP0003878_abnormal_ear_physiology1.00721281
112MP0005377_hearing/vestibular/ear_phenot1.00721281
113MP0001765_abnormal_ion_homeostasis1.00257313
114MP0002184_abnormal_innervation0.99541819
115MP0005253_abnormal_eye_physiology0.99320940
116MP0001529_abnormal_vocalization0.97898954
117MP0003122_maternal_imprinting0.96908100
118MP0004811_abnormal_neuron_physiology0.96576420
119MP0002132_abnormal_respiratory_system0.95049622
120MP0000566_synostosis0.94206612
121MP0003011_delayed_dark_adaptation0.93558727
122MP0003566_abnormal_cell_adhesion0.93523259
123MP0003136_yellow_coat_color0.92600702
124MP0002837_dystrophic_cardiac_calcinosis0.91066583
125MP0000026_abnormal_inner_ear0.90859660
126MP0005670_abnormal_white_adipose0.89486157
127MP0004185_abnormal_adipocyte_glucose0.88568525
128MP0003632_abnormal_nervous_system0.88034077
129MP0008438_abnormal_cutaneous_collagen0.85226400
130MP0000631_abnormal_neuroendocrine_gland0.84603453
131MP0001851_eye_inflammation0.82633204
132MP0005647_abnormal_sex_gland0.82387617
133MP0002282_abnormal_trachea_morphology0.81816118
134MP0003075_altered_response_to0.81687237
135MP0001191_abnormal_skin_condition0.80521305
136MP0000920_abnormal_myelination0.79029959
137MP0006072_abnormal_retinal_apoptosis0.78958579
138MP0003436_decreased_susceptibility_to0.78821175
139MP0003283_abnormal_digestive_organ0.78509566
140MP0004147_increased_porphyrin_level0.77720318
141MP0002069_abnormal_eating/drinking_beha0.76011551
142MP0003656_abnormal_erythrocyte_physiolo0.75842825
143MP0005167_abnormal_blood-brain_barrier0.75747701
144MP0005584_abnormal_enzyme/coenzyme_acti0.75268215
145MP0002752_abnormal_somatic_nervous0.74394231
146MP0005499_abnormal_olfactory_system0.73695932
147MP0005394_taste/olfaction_phenotype0.73695932
148MP0005023_abnormal_wound_healing0.71154503
149MP0002876_abnormal_thyroid_physiology0.70711824
150MP0009053_abnormal_anal_canal0.70098211
151MP0003045_fibrosis0.69763542
152MP0008789_abnormal_olfactory_epithelium0.69617000
153MP0002152_abnormal_brain_morphology0.69566057
154MP0003938_abnormal_ear_development0.69172500
155MP0001346_abnormal_lacrimal_gland0.68833556
156MP0001944_abnormal_pancreas_morphology0.67994868
157MP0005666_abnormal_adipose_tissue0.67255238
158MP0008469_abnormal_protein_level0.65794984
159MP0001764_abnormal_homeostasis0.65656488
160MP0009763_increased_sensitivity_to0.65112845
161MP0009643_abnormal_urine_homeostasis0.63953736
162MP0004782_abnormal_surfactant_physiolog0.62752405
163MP0005165_increased_susceptibility_to0.60519253
164MP0005535_abnormal_body_temperature0.58848593
165MP0004130_abnormal_muscle_cell0.57874224
166MP0003941_abnormal_skin_development0.57851589
167MP0000598_abnormal_liver_morphology0.57042602
168MP0009384_cardiac_valve_regurgitation0.54232632
169MP0002332_abnormal_exercise_endurance0.54150996
170MP0004885_abnormal_endolymph0.51546237
171MP0000465_gastrointestinal_hemorrhage0.48991604
172MP0002234_abnormal_pharynx_morphology0.48954401
173MP0009642_abnormal_blood_homeostasis0.48086989
174MP0001661_extended_life_span0.47647034
175MP0002971_abnormal_brown_adipose0.46947265
176MP0003690_abnormal_glial_cell0.46463169
177MP0006138_congestive_heart_failure0.45192836
178MP0003303_peritoneal_inflammation0.44542976
179MP0005595_abnormal_vascular_smooth0.42004957
180MP0001756_abnormal_urination0.41460728
181MP0005464_abnormal_platelet_physiology0.41232141
182MP0001340_abnormal_eyelid_morphology0.40977884
183MP0002928_abnormal_bile_duct0.39620092
184MP0002896_abnormal_bone_mineralization0.37649812
185MP0002090_abnormal_vision0.36548759
186MP0000627_abnormal_mammary_gland0.36308901
187MP0000767_abnormal_smooth_muscle0.36264040
188MP0010368_abnormal_lymphatic_system0.35491721

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of nail color (HP:0100643)9.02432883
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.54422940
3Absent/shortened dynein arms (HP:0200106)7.84405383
4Dynein arm defect of respiratory motile cilia (HP:0012255)7.84405383
5Abnormal respiratory motile cilium morphology (HP:0005938)7.76762338
6Abnormal respiratory epithelium morphology (HP:0012253)7.76762338
7Abnormal respiratory motile cilium physiology (HP:0012261)7.45637234
8Abnormal ciliary motility (HP:0012262)7.44370900
9Rhinitis (HP:0012384)6.88423225
10Thick nail (HP:0001805)6.71417119
11Intrahepatic cholestasis (HP:0001406)5.90028756
12Prolonged partial thromboplastin time (HP:0003645)5.52950243
13Alopecia of scalp (HP:0002293)5.31410709
14Deep venous thrombosis (HP:0002625)5.16297720
15Chronic bronchitis (HP:0004469)4.99375771
16Bronchiectasis (HP:0002110)4.86399766
17Palmoplantar hyperkeratosis (HP:0000972)4.83175660
18Abnormality of monocarboxylic acid metabolism (HP:0010996)4.78446061
19Abnormality of aromatic amino acid family metabolism (HP:0004338)4.67223704
20Complement deficiency (HP:0004431)4.64043289
21Xanthomatosis (HP:0000991)4.57508298
22Plantar hyperkeratosis (HP:0007556)4.54091765
23Palmar hyperkeratosis (HP:0010765)4.50684103
24Hypotrichosis (HP:0001006)4.35704775
25Oral leukoplakia (HP:0002745)4.23674512
26Increased IgE level (HP:0003212)4.06678926
27Nasal polyposis (HP:0100582)3.96458364
28Epidermoid cyst (HP:0200040)3.90728861
29Focal motor seizures (HP:0011153)3.88512504
30Pancreatic fibrosis (HP:0100732)3.86775368
31Joint hemorrhage (HP:0005261)3.81982584
32True hermaphroditism (HP:0010459)3.79521693
33Woolly hair (HP:0002224)3.74856537
34Myocardial infarction (HP:0001658)3.73805734
35Follicular hyperkeratosis (HP:0007502)3.73301962
36Pancreatic cysts (HP:0001737)3.71967657
37Hypobetalipoproteinemia (HP:0003563)3.56251342
38Onycholysis (HP:0001806)3.46728730
39Hyperlipoproteinemia (HP:0010980)3.46285034
40Fat malabsorption (HP:0002630)3.43833974
41Abnormality of complement system (HP:0005339)3.39762020
42Nephronophthisis (HP:0000090)3.35304877
43Molar tooth sign on MRI (HP:0002419)3.33343695
44Abnormality of midbrain morphology (HP:0002418)3.33343695
45Focal seizures (HP:0007359)3.30430081
46Abnormality of the common coagulation pathway (HP:0010990)3.14340318
47Abnormality of the nasal mucosa (HP:0000433)3.14152578
48Cystic liver disease (HP:0006706)3.09099061
49Fragile nails (HP:0001808)3.06260271
50Myokymia (HP:0002411)3.05761668
51Chronic sinusitis (HP:0011109)3.05680596
52Occipital encephalocele (HP:0002085)3.05056058
53Milia (HP:0001056)3.04669955
54Febrile seizures (HP:0002373)3.04555127
55Hypoalphalipoproteinemia (HP:0003233)3.04437908
56Right ventricular cardiomyopathy (HP:0011663)3.03999934
57Hypolipoproteinemia (HP:0010981)3.01067516
58Neonatal onset (HP:0003623)2.97085627
59Recurrent sinusitis (HP:0011108)2.96763896
60Recurrent gram-negative bacterial infections (HP:0005420)2.95732417
61Epileptic encephalopathy (HP:0200134)2.95560261
62Erythroderma (HP:0001019)2.95412505
63Bronchitis (HP:0012387)2.84834791
64Infertility (HP:0000789)2.78099452
65Metaphyseal dysplasia (HP:0100255)2.75842307
66Ketosis (HP:0001946)2.75699690
67Steatorrhea (HP:0002570)2.74401467
68Abnormality of methionine metabolism (HP:0010901)2.71931449
69Limb dystonia (HP:0002451)2.71543880
70Spontaneous abortion (HP:0005268)2.70376247
71Abnormality of sulfur amino acid metabolism (HP:0004339)2.69997468
72Nail dystrophy (HP:0008404)2.69138217
73Medial flaring of the eyebrow (HP:0010747)2.69117577
74Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.68746262
75Abnormality of the renal medulla (HP:0100957)2.66337167
76Gait imbalance (HP:0002141)2.65825709
77Pili torti (HP:0003777)2.64571229
78Abnormality of aspartate family amino acid metabolism (HP:0010899)2.62014420
79Abnormality of glutamine family amino acid metabolism (HP:0010902)2.60049731
80Systemic lupus erythematosus (HP:0002725)2.57761101
81Decreased circulating renin level (HP:0003351)2.57625593
82Abnormal blistering of the skin (HP:0008066)2.57559334
83Hypercholesterolemia (HP:0003124)2.51141299
84Atonic seizures (HP:0010819)2.50416994
85Hyperammonemia (HP:0001987)2.50002153
86Progressive cerebellar ataxia (HP:0002073)2.48689353
87Recurrent bacterial skin infections (HP:0005406)2.39955155
88Conjugated hyperbilirubinemia (HP:0002908)2.38990324
89Erythema (HP:0010783)2.36929405
90Recurrent otitis media (HP:0000403)2.35733166
91Chronic otitis media (HP:0000389)2.33215136
92Absent speech (HP:0001344)2.32745714
93Palmoplantar keratoderma (HP:0000982)2.31948920
94Ridged nail (HP:0001807)2.31542329
95Dialeptic seizures (HP:0011146)2.31254690
96Hyperglycinemia (HP:0002154)2.31147781
97Abnormal drinking behavior (HP:0030082)2.31092847
98Polydipsia (HP:0001959)2.31092847
99Chronic hepatic failure (HP:0100626)2.30277407
100Abnormal hair laboratory examination (HP:0003328)2.28812169
101Hypoglycemic coma (HP:0001325)2.27411391
102Laryngomalacia (HP:0001601)2.27225655
103Hyperglycinuria (HP:0003108)2.26401187
104Pruritus (HP:0000989)2.25420317
105Tubular atrophy (HP:0000092)2.25160637
106Abnormality of glycine metabolism (HP:0010895)2.24426577
107Abnormality of serine family amino acid metabolism (HP:0010894)2.24426577
108Abnormality of pyrimidine metabolism (HP:0004353)2.23025823
109Skin nodule (HP:0200036)2.22280080
110Congenital hepatic fibrosis (HP:0002612)2.19563145
111Congenital primary aphakia (HP:0007707)2.18269580
112Polyphagia (HP:0002591)2.17414665
113Prostate neoplasm (HP:0100787)2.17194879
114Hyperactive renin-angiotensin system (HP:0000841)2.15975277
115Absence seizures (HP:0002121)2.15687277
116Conjunctival hamartoma (HP:0100780)2.14836929
117Abnormality of the intrinsic pathway (HP:0010989)2.14171669
118Hemiparesis (HP:0001269)2.10195335
119Polycythemia (HP:0001901)2.09941691
120Gangrene (HP:0100758)2.09893841
121Hyperventilation (HP:0002883)2.09557533
122Congenital stationary night blindness (HP:0007642)2.08353855
123Generalized tonic-clonic seizures (HP:0002069)2.07043534
124Postaxial foot polydactyly (HP:0001830)2.06089660
125Furrowed tongue (HP:0000221)2.04331274
126Abnormality of the renal cortex (HP:0011035)2.04233383
127Anencephaly (HP:0002323)2.04212084
128Abnormality of renin-angiotensin system (HP:0000847)2.02949369
129Abnormal eating behavior (HP:0100738)2.02825846
130Nephrogenic diabetes insipidus (HP:0009806)2.01368680
131Sleep apnea (HP:0010535)2.01129753
132Congenital ichthyosiform erythroderma (HP:0007431)2.01050865
133Glomerulonephritis (HP:0000099)2.00932103
134Decreased central vision (HP:0007663)1.99620057
135Male pseudohermaphroditism (HP:0000037)1.98383804
136Spastic diplegia (HP:0001264)1.97444605
137Hyperbilirubinemia (HP:0002904)1.95837459
138Eczematoid dermatitis (HP:0000976)1.92298810
139Broad-based gait (HP:0002136)1.92259730
140Gingival bleeding (HP:0000225)1.91651915
141Torticollis (HP:0000473)1.91050986
142Neonatal respiratory distress (HP:0002643)1.89746629
143Vascular calcification (HP:0004934)1.89692305
144Ankle clonus (HP:0011448)1.89230256
145Abnormality of binocular vision (HP:0011514)1.89184530
146Diplopia (HP:0000651)1.89184530
147Renal cortical cysts (HP:0000803)1.87863106
148Neurofibrillary tangles (HP:0002185)1.87075470
149Amyloidosis (HP:0011034)1.87009690
150Abnormality of the parietal bone (HP:0002696)1.86692330
151Hyperaldosteronism (HP:0000859)1.86382226
152Corneal erosion (HP:0200020)1.85965661
153Status epilepticus (HP:0002133)1.85850163
154Esophageal varix (HP:0002040)1.85350112
155Papilledema (HP:0001085)1.85049051
156Ketoacidosis (HP:0001993)1.84671948
157Abnormality of nucleobase metabolism (HP:0010932)1.84185620
158Sclerocornea (HP:0000647)1.81857364
159Male infertility (HP:0003251)1.81731979
160Progressive external ophthalmoplegia (HP:0000590)1.80111156
161Peritonitis (HP:0002586)1.79382460
162Mutism (HP:0002300)1.79279102
163Corneal dystrophy (HP:0001131)1.77973162
164Brittle hair (HP:0002299)1.77839485
165Hyporeflexia of lower limbs (HP:0002600)1.77305618
166Abnormality of macular pigmentation (HP:0008002)1.76938875
167Cardiovascular calcification (HP:0011915)1.76897109
168Stroke (HP:0001297)1.75930547
169Aplasia/Hypoplasia of the spleen (HP:0010451)1.75605816
170Aplasia/Hypoplasia of the tongue (HP:0010295)1.75037238
171Spinal cord lesions (HP:0100561)1.74503102
172Syringomyelia (HP:0003396)1.74503102
173Visual hallucinations (HP:0002367)1.73455412
174Menorrhagia (HP:0000132)1.73294091
175Abnormal gallbladder morphology (HP:0012437)1.71888566
176Renal salt wasting (HP:0000127)1.71665288
177Asplenia (HP:0001746)1.71391493
178Ventricular fibrillation (HP:0001663)1.71037974
179Type II lissencephaly (HP:0007260)1.70788498
180Hypokalemic alkalosis (HP:0001949)1.69484163
181Hypohidrosis (HP:0000966)1.69369365
182Abnormal rod and cone electroretinograms (HP:0008323)1.68266728
183Cholelithiasis (HP:0001081)1.67915631
184Focal dystonia (HP:0004373)1.67815785
185Genital tract atresia (HP:0001827)1.67657850
186Vaginal atresia (HP:0000148)1.66907378
187Epileptiform EEG discharges (HP:0011182)1.66023281
188Gaze-evoked nystagmus (HP:0000640)1.65710000
189Urticaria (HP:0001025)1.64846575
190Hemiplegia (HP:0002301)1.61707466
191Increased circulating renin level (HP:0000848)1.60867028
192Postaxial hand polydactyly (HP:0001162)1.60704490
193Bile duct proliferation (HP:0001408)1.60305983
194Abnormal biliary tract physiology (HP:0012439)1.60305983
195Large for gestational age (HP:0001520)1.59717921
196Polyuria (HP:0000103)1.59714082
197Prolonged QT interval (HP:0001657)1.57657926
198Supranuclear gaze palsy (HP:0000605)1.57400698
199Nephropathy (HP:0000112)1.57274901
200EEG with generalized epileptiform discharges (HP:0011198)1.56208342

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.50486718
2PIK3CG4.19153423
3MST1R3.77439139
4MARK13.40373707
5FGFR43.01261792
6EPHA42.97295892
7MAPK132.87230039
8NTRK32.87120687
9SIK12.74306409
10ERBB42.36713484
11PINK12.23293125
12BCKDK2.12581180
13FRK2.08660259
14UHMK12.08132532
15PAK62.01211900
16TYK21.92771023
17ADRBK21.88430704
18TAOK31.82310537
19PNCK1.80750098
20CAMKK11.78783033
21MYLK1.77171987
22MAPK111.72302009
23MAP3K41.68779863
24MET1.62684236
25INSRR1.58999314
26FER1.58007018
27CDK61.57926255
28DMPK1.57888205
29CAMKK21.52072718
30PAK21.51548953
31JAK31.49939904
32WNK31.44391605
33OXSR11.44309297
34CSK1.44249475
35RIPK11.40649460
36PRKCG1.39110450
37MAP3K61.31344633
38OBSCN1.30803117
39MINK11.30577678
40MAP4K21.30163745
41NME11.27532207
42MAP2K41.26469772
43TRIB31.23264506
44JAK11.21975098
45PLK21.20325172
46MAP3K141.19020272
47CASK1.18335885
48GRK51.18199963
49MST41.14048128
50BLK1.11651759
51MAP2K71.10882625
52TTN1.10730733
53CAMK11.10237022
54PKN11.09616598
55CDK191.09330789
56TXK1.08472867
57MAPKAPK31.07903265
58MAPKAPK51.07802646
59ZAP701.06231130
60MAPK41.05527881
61JAK21.03340555
62DYRK21.02895680
63PTK2B1.01662924
64CDK50.99204179
65PRKD30.98139741
66CAMK2A0.97961891
67CAMK1D0.97577063
68MAP3K70.94652624
69BMX0.92943510
70IRAK30.91108590
71LATS10.88295879
72FLT30.86432392
73PHKG20.85981675
74PHKG10.85981675
75EPHB10.85447705
76ERBB20.85374702
77NEK90.83945348
78PRKCE0.83785578
79WNK40.83712255
80PRKCH0.83599049
81PRKCZ0.82248406
82EPHB20.80808622
83MARK20.79384561
84RET0.78259504
85PAK30.78102679
86IKBKB0.78016230
87TNIK0.76401323
88MAPK120.75705629
89IKBKE0.74737934
90SGK4940.74547159
91SGK2230.74547159
92PTK20.73909762
93RIPK40.73684516
94CAMK2B0.73582105
95DAPK30.73448112
96PTK60.72727710
97TAOK10.72364681
98GRK60.71794981
99DAPK10.71765414
100KDR0.69073018
101MAP3K20.68633460
102PRKACG0.68468626
103DAPK20.67651584
104FGFR10.67194234
105BMPR1B0.67146718
106NEK60.66092078
107PRKCQ0.65389882
108MAP2K10.65238070
109SGK10.63768859
110PRKAA20.63403332
111MAP3K10.63185251
112TNK20.62827300
113PRKCI0.62549445
114ABL20.62042307
115GRK10.61916173
116STK380.61409521
117FGFR20.61353914
118TBK10.61253259
119PDPK10.61170324
120MAP3K120.59366550
121YES10.58972039
122CAMK2G0.58796086
123GRK70.58450942
124PIK3CA0.58098801
125STK390.57515273
126STK110.56522539
127NTRK20.56088547
128PKN20.55858313
129CSNK1G20.55573954
130CAMK1G0.55402175
131PRKCA0.55296470
132LATS20.54883869
133MAP3K80.54759984
134TLK10.51368306
135ADRBK10.50348903
136SIK20.50193175
137CSNK1D0.49630384
138MAPK150.48744383
139FGFR30.47135316
140KIT0.46210980
141EPHA20.46113434
142CAMK40.45582580
143MAP2K60.45251509
144CAMK2D0.43574307
145ROCK10.43378927
146CSNK1A10.43112733
147MAP2K20.42997326
148ABL10.42086948
149PRKG10.41120415
150SYK0.41055635
151TIE10.40482508
152SGK20.40093568
153RPS6KA30.40078208
154RPS6KL10.39939455
155RPS6KC10.39939455
156TGFBR20.39921811
157DYRK1A0.38077606
158RPS6KA20.37668334
159FES0.37582108
160NTRK10.37438779
161MAP3K110.36506853
162PRKACA0.35617746
163PDK10.34663926
164PRKAA10.33758117
165ERBB30.33170196
166MAP3K90.32749036
167LIMK10.32264389
168CDK30.31578344

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.83748235
2Nicotine addiction_Homo sapiens_hsa050333.77442846
3Nitrogen metabolism_Homo sapiens_hsa009103.33019824
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.12816378
5Arginine biosynthesis_Homo sapiens_hsa002203.03690733
6Complement and coagulation cascades_Homo sapiens_hsa046103.01956339
7Tryptophan metabolism_Homo sapiens_hsa003802.64153977
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.63303921
9Synaptic vesicle cycle_Homo sapiens_hsa047212.60481542
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.58469361
11Staphylococcus aureus infection_Homo sapiens_hsa051502.33015410
12Fatty acid degradation_Homo sapiens_hsa000712.30765240
13Fatty acid elongation_Homo sapiens_hsa000622.27770475
14Circadian entrainment_Homo sapiens_hsa047132.17949525
15GABAergic synapse_Homo sapiens_hsa047272.15091494
16Morphine addiction_Homo sapiens_hsa050322.13008523
17Histidine metabolism_Homo sapiens_hsa003402.11008050
18Steroid hormone biosynthesis_Homo sapiens_hsa001402.10731495
19Insulin secretion_Homo sapiens_hsa049112.08736715
20Steroid biosynthesis_Homo sapiens_hsa001002.04792620
21Amphetamine addiction_Homo sapiens_hsa050312.03859380
22PPAR signaling pathway_Homo sapiens_hsa033202.03572154
23Glutamatergic synapse_Homo sapiens_hsa047242.02478068
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.01449326
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.99403602
26Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.95244126
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.94399431
28Phototransduction_Homo sapiens_hsa047441.92210669
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.91399023
30Peroxisome_Homo sapiens_hsa041461.90872940
31Butanoate metabolism_Homo sapiens_hsa006501.87976338
32Caffeine metabolism_Homo sapiens_hsa002321.84977886
33Bile secretion_Homo sapiens_hsa049761.80600088
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.79926801
35Fatty acid metabolism_Homo sapiens_hsa012121.79820645
36beta-Alanine metabolism_Homo sapiens_hsa004101.77172804
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.72639628
38Taste transduction_Homo sapiens_hsa047421.70815629
39Pentose and glucuronate interconversions_Homo sapiens_hsa000401.67831302
40Propanoate metabolism_Homo sapiens_hsa006401.64526365
41Cocaine addiction_Homo sapiens_hsa050301.63339741
42Salivary secretion_Homo sapiens_hsa049701.62098210
43Phenylalanine metabolism_Homo sapiens_hsa003601.61446870
44Retinol metabolism_Homo sapiens_hsa008301.60330062
45Chemical carcinogenesis_Homo sapiens_hsa052041.55568692
46Dopaminergic synapse_Homo sapiens_hsa047281.55332631
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.54045527
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.51761554
49Collecting duct acid secretion_Homo sapiens_hsa049661.51632671
50Serotonergic synapse_Homo sapiens_hsa047261.46343774
51Tyrosine metabolism_Homo sapiens_hsa003501.43224998
52ABC transporters_Homo sapiens_hsa020101.40815114
53Gastric acid secretion_Homo sapiens_hsa049711.34406831
54Fat digestion and absorption_Homo sapiens_hsa049751.33178571
55Olfactory transduction_Homo sapiens_hsa047401.33115645
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.32441325
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.30566607
58Cardiac muscle contraction_Homo sapiens_hsa042601.28402917
59Aldosterone synthesis and secretion_Homo sapiens_hsa049251.26261323
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25953022
61Calcium signaling pathway_Homo sapiens_hsa040201.22872548
62Oxidative phosphorylation_Homo sapiens_hsa001901.22847243
63Drug metabolism - other enzymes_Homo sapiens_hsa009831.18466804
64Starch and sucrose metabolism_Homo sapiens_hsa005001.15537299
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.14563204
66Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.12876108
67cAMP signaling pathway_Homo sapiens_hsa040241.09865527
68Oxytocin signaling pathway_Homo sapiens_hsa049211.09500419
69Huntingtons disease_Homo sapiens_hsa050161.05814025
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.05071275
71Cholinergic synapse_Homo sapiens_hsa047251.04713843
72Renin secretion_Homo sapiens_hsa049241.04124943
73Long-term potentiation_Homo sapiens_hsa047201.01374527
74Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97275032
75Vitamin digestion and absorption_Homo sapiens_hsa049770.97112093
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.96292298
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95679849
782-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.95670356
79Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.92906061
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92762286
81Regulation of autophagy_Homo sapiens_hsa041400.90690881
82Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.88962027
83Long-term depression_Homo sapiens_hsa047300.88169636
84Vitamin B6 metabolism_Homo sapiens_hsa007500.87414037
85Fatty acid biosynthesis_Homo sapiens_hsa000610.86214006
86Selenocompound metabolism_Homo sapiens_hsa004500.85627989
87Pyruvate metabolism_Homo sapiens_hsa006200.84488923
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.82378826
89Circadian rhythm_Homo sapiens_hsa047100.80997637
90Prion diseases_Homo sapiens_hsa050200.79986892
91Arginine and proline metabolism_Homo sapiens_hsa003300.79101352
92Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.78809618
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77931417
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.77513602
95Parkinsons disease_Homo sapiens_hsa050120.75301717
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75012900
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74597030
98Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74355886
99Alzheimers disease_Homo sapiens_hsa050100.73342262
100Lysine degradation_Homo sapiens_hsa003100.72957430
101Sulfur metabolism_Homo sapiens_hsa009200.70995113
102Carbon metabolism_Homo sapiens_hsa012000.69055556
103Pancreatic secretion_Homo sapiens_hsa049720.66272352
104Linoleic acid metabolism_Homo sapiens_hsa005910.65455970
105Biosynthesis of amino acids_Homo sapiens_hsa012300.65203834
106Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.65134800
107Glycerolipid metabolism_Homo sapiens_hsa005610.64488049
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.63305097
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62781691
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61673226
111Ovarian steroidogenesis_Homo sapiens_hsa049130.58060626
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55057843
113Glutathione metabolism_Homo sapiens_hsa004800.53180306
114Type II diabetes mellitus_Homo sapiens_hsa049300.52770749
115Axon guidance_Homo sapiens_hsa043600.47715401
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47699003
117Folate biosynthesis_Homo sapiens_hsa007900.47626202
118Type I diabetes mellitus_Homo sapiens_hsa049400.44097188
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43638267
120GnRH signaling pathway_Homo sapiens_hsa049120.42850518
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41048696
122Sphingolipid metabolism_Homo sapiens_hsa006000.41018635
123Insulin resistance_Homo sapiens_hsa049310.39780589
124cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39726747
125Dorso-ventral axis formation_Homo sapiens_hsa043200.37612873
126Amoebiasis_Homo sapiens_hsa051460.35223012
127Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35164100
128Arachidonic acid metabolism_Homo sapiens_hsa005900.34774510
129Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32910834
130Adipocytokine signaling pathway_Homo sapiens_hsa049200.30627540
131Melanogenesis_Homo sapiens_hsa049160.30619166
132Estrogen signaling pathway_Homo sapiens_hsa049150.30130368
133Vascular smooth muscle contraction_Homo sapiens_hsa042700.25469930
134Metabolic pathways_Homo sapiens_hsa011000.22816335
135Sulfur relay system_Homo sapiens_hsa041220.21131784
136Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.20122156
137Pertussis_Homo sapiens_hsa051330.19262859
138Pentose phosphate pathway_Homo sapiens_hsa000300.16511452
139Glucagon signaling pathway_Homo sapiens_hsa049220.15949185
140African trypanosomiasis_Homo sapiens_hsa051430.15682380
141Graft-versus-host disease_Homo sapiens_hsa053320.14727460
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.14119066
143ECM-receptor interaction_Homo sapiens_hsa045120.11352280
144Hepatitis C_Homo sapiens_hsa051600.09527404
145Ether lipid metabolism_Homo sapiens_hsa005650.07430693
146Platelet activation_Homo sapiens_hsa046110.03600169
147RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.01883900
148Malaria_Homo sapiens_hsa051440.01747830
149Thyroid hormone synthesis_Homo sapiens_hsa049180.01126530
150Mineral absorption_Homo sapiens_hsa049780.00118181
151Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.0780569
152Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0775866
153Adherens junction_Homo sapiens_hsa04520-0.0745585
154Notch signaling pathway_Homo sapiens_hsa04330-0.0568747
155Insulin signaling pathway_Homo sapiens_hsa04910-0.0491667
156One carbon pool by folate_Homo sapiens_hsa00670-0.0297678
157Protein digestion and absorption_Homo sapiens_hsa04974-0.0296534
158Dilated cardiomyopathy_Homo sapiens_hsa05414-0.0213329
159Leishmaniasis_Homo sapiens_hsa05140-0.0146257

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