CES5A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They also participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene, also called CES5, is predominantly expressed in peripheral tissues, including brain, kidney, lung and testis. It encodes a secreted enzyme. Because of high levels in the urine of male domestic cats, this enzyme is also called cauxin (carboxylesterase-like urinary excreted protein). The enzyme functions in regulating the production of a pheromone precursor and may contribute to lipid and cholesterol transfer processes within male reproductive fluids. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tachykinin receptor signaling pathway (GO:0007217)8.09577557
2exogenous drug catabolic process (GO:0042738)6.14521521
3drug catabolic process (GO:0042737)6.07481323
4epoxygenase P450 pathway (GO:0019373)5.94787833
5glyoxylate metabolic process (GO:0046487)5.83591689
6regulation of protein activation cascade (GO:2000257)5.58064932
7drug metabolic process (GO:0017144)5.41710727
8regulation of complement activation (GO:0030449)5.31535337
9negative regulation of protein activation cascade (GO:2000258)5.29413573
10omega-hydroxylase P450 pathway (GO:0097267)5.23983840
11L-phenylalanine catabolic process (GO:0006559)5.16530398
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.16530398
13negative regulation of complement activation (GO:0045916)5.12949819
14bile acid biosynthetic process (GO:0006699)5.05732615
15cellular glucuronidation (GO:0052695)4.99191354
16flavonoid metabolic process (GO:0009812)4.98711112
17oxidative demethylation (GO:0070989)4.98455384
18glucuronate metabolic process (GO:0019585)4.77171326
19uronic acid metabolic process (GO:0006063)4.77171326
20cellular ketone body metabolic process (GO:0046950)4.76421328
21alkaloid metabolic process (GO:0009820)4.71060515
22complement activation, alternative pathway (GO:0006957)4.66558103
23phenylpropanoid metabolic process (GO:0009698)4.65551775
24regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.49426507
25signal peptide processing (GO:0006465)4.47547073
26erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.44992151
27L-phenylalanine metabolic process (GO:0006558)4.44992151
28amino-acid betaine metabolic process (GO:0006577)4.44622832
29regulation of fibrinolysis (GO:0051917)4.44481959
30aromatic amino acid family catabolic process (GO:0009074)4.29300281
31serine family amino acid catabolic process (GO:0009071)4.24621733
32regulation of triglyceride catabolic process (GO:0010896)4.22997458
33blood coagulation, intrinsic pathway (GO:0007597)4.22405237
34coenzyme catabolic process (GO:0009109)4.21220207
35ketone body metabolic process (GO:1902224)4.14956635
36bile acid metabolic process (GO:0008206)4.12442625
37negative regulation of fibrinolysis (GO:0051918)4.05200295
38xenobiotic catabolic process (GO:0042178)3.97878320
39negative regulation of humoral immune response (GO:0002921)3.87591917
40ethanol oxidation (GO:0006069)3.87428449
41S-adenosylmethionine metabolic process (GO:0046500)3.84615521
42ionotropic glutamate receptor signaling pathway (GO:0035235)3.84272237
43glycine metabolic process (GO:0006544)3.82974050
44presynaptic membrane assembly (GO:0097105)3.79807394
45neuron cell-cell adhesion (GO:0007158)3.79648613
46retina layer formation (GO:0010842)3.73305677
47glutamate receptor signaling pathway (GO:0007215)3.66056834
48fibrinolysis (GO:0042730)3.65921412
49amino acid salvage (GO:0043102)3.64567714
50L-methionine salvage (GO:0071267)3.64567714
51L-methionine biosynthetic process (GO:0071265)3.64567714
52G-protein coupled receptor internalization (GO:0002031)3.63529207
53protein activation cascade (GO:0072376)3.62458206
54righting reflex (GO:0060013)3.59728083
55keratinocyte development (GO:0003334)3.59149721
56limb bud formation (GO:0060174)3.58499630
57retinal cone cell development (GO:0046549)3.56623591
58triglyceride homeostasis (GO:0070328)3.52538706
59acylglycerol homeostasis (GO:0055090)3.52538706
60respiratory tube development (GO:0030323)3.52392382
61tryptophan catabolic process (GO:0006569)3.51762400
62indole-containing compound catabolic process (GO:0042436)3.51762400
63indolalkylamine catabolic process (GO:0046218)3.51762400
64axon ensheathment in central nervous system (GO:0032291)3.51440877
65central nervous system myelination (GO:0022010)3.51440877
66alpha-amino acid catabolic process (GO:1901606)3.45555177
67presynaptic membrane organization (GO:0097090)3.45544706
68regulation of timing of cell differentiation (GO:0048505)3.43318307
69cellular response to epinephrine stimulus (GO:0071872)3.42658943
70complement activation (GO:0006956)3.42234660
71triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.42079022
72long-chain fatty acid biosynthetic process (GO:0042759)3.40762835
73cofactor catabolic process (GO:0051187)3.39344430
74peptidyl-glutamic acid carboxylation (GO:0017187)3.38982035
75protein carboxylation (GO:0018214)3.38982035
76GPI anchor biosynthetic process (GO:0006506)3.36513415
77very long-chain fatty acid metabolic process (GO:0000038)3.35567914
78gamma-aminobutyric acid signaling pathway (GO:0007214)3.34869219
79serine family amino acid metabolic process (GO:0009069)3.29109071
80GPI anchor metabolic process (GO:0006505)3.21818811
81reverse cholesterol transport (GO:0043691)3.20377125
82negative regulation of synaptic transmission, GABAergic (GO:0032229)3.20202492
83bile acid and bile salt transport (GO:0015721)3.19598103
84response to misfolded protein (GO:0051788)3.17871248
85tyrosine metabolic process (GO:0006570)3.16554400
86superoxide anion generation (GO:0042554)3.16363488
87neuron recognition (GO:0008038)3.16073451
88import into cell (GO:0098657)3.14470011
89regulation of development, heterochronic (GO:0040034)3.13651831
90serine family amino acid biosynthetic process (GO:0009070)3.13149264
91regulation of humoral immune response (GO:0002920)3.12577337
92glutamate metabolic process (GO:0006536)3.12146905
93cell morphogenesis involved in neuron differentiation (GO:0048667)3.10782416
94cranial nerve morphogenesis (GO:0021602)3.07428644
95L-amino acid import (GO:0043092)3.06945578
96response to epinephrine (GO:0071871)3.06262529
97complement activation, classical pathway (GO:0006958)3.06181175
98tryptophan metabolic process (GO:0006568)3.05585796
99transmission of nerve impulse (GO:0019226)3.05187212
100neuronal action potential propagation (GO:0019227)3.04673410
101postsynaptic membrane organization (GO:0001941)3.02650852
102aromatic amino acid family metabolic process (GO:0009072)3.02603914
103regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.99818560
104preassembly of GPI anchor in ER membrane (GO:0016254)2.98571819
105cerebral cortex radially oriented cell migration (GO:0021799)2.97949824
106ethanol metabolic process (GO:0006067)2.97869455
107polyol transport (GO:0015791)2.97134169
108eye photoreceptor cell differentiation (GO:0001754)2.96844267
109photoreceptor cell differentiation (GO:0046530)2.96844267
110dicarboxylic acid catabolic process (GO:0043649)2.96732225
111cellular amino acid catabolic process (GO:0009063)2.94632416
112xenobiotic metabolic process (GO:0006805)2.94384101
113G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.93881300
114negative regulation of blood coagulation (GO:0030195)2.93557314
115negative regulation of hemostasis (GO:1900047)2.93557314
116startle response (GO:0001964)2.93209858
117amine catabolic process (GO:0009310)2.92556940
118cellular biogenic amine catabolic process (GO:0042402)2.92556940
119tetrahydrofolate metabolic process (GO:0046653)2.92341439
120methionine biosynthetic process (GO:0009086)2.91271872
121neuron remodeling (GO:0016322)2.89898030
122negative regulation of B cell mediated immunity (GO:0002713)2.89582534
123negative regulation of immunoglobulin mediated immune response (GO:0002890)2.89582534
124C4-dicarboxylate transport (GO:0015740)2.85232405
125lysine catabolic process (GO:0006554)2.85139652
126lysine metabolic process (GO:0006553)2.85139652
127positive regulation of protein kinase C signaling (GO:0090037)2.84800067
128dendritic spine morphogenesis (GO:0060997)2.84497381
129plasma lipoprotein particle remodeling (GO:0034369)2.84292041
130protein-lipid complex remodeling (GO:0034368)2.84292041
131macromolecular complex remodeling (GO:0034367)2.84292041
132opsonization (GO:0008228)2.84178307
133negative regulation of cholesterol transport (GO:0032375)2.84092722
134negative regulation of sterol transport (GO:0032372)2.84092722
135acute-phase response (GO:0006953)2.83687647
136regulation of phospholipase A2 activity (GO:0032429)2.83636223
137protein localization to synapse (GO:0035418)2.80895596
138reflex (GO:0060004)2.80045449
139arginine metabolic process (GO:0006525)2.79553182
140positive regulation of action potential (GO:0045760)2.79414423
141urea metabolic process (GO:0019627)2.79368308
142regulation of acrosome reaction (GO:0060046)2.79121721
143positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.78598220
144regulation of non-canonical Wnt signaling pathway (GO:2000050)2.76569201
145synaptic transmission, glutamatergic (GO:0035249)2.74220412
146vocalization behavior (GO:0071625)2.74057026
147photoreceptor cell maintenance (GO:0045494)2.72372940
148regulation of feeding behavior (GO:0060259)2.72014010
149short-term memory (GO:0007614)2.71058436
150axonal fasciculation (GO:0007413)2.69018149
151regulation of pigment cell differentiation (GO:0050932)2.68348278
152neuron-neuron synaptic transmission (GO:0007270)2.67975624
153auditory receptor cell stereocilium organization (GO:0060088)2.67237078
154inner ear receptor stereocilium organization (GO:0060122)2.66434691
155positive regulation of synapse assembly (GO:0051965)2.63924815
156organ growth (GO:0035265)2.63803104
157regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.62702142
158negative regulation of execution phase of apoptosis (GO:1900118)2.61387562
159cilium movement (GO:0003341)2.60326526
160positive regulation of dendritic spine development (GO:0060999)2.60270306
161amino acid import (GO:0043090)2.59650423
162calcium ion import (GO:0070509)2.58336578
163cranial nerve development (GO:0021545)2.57648090
164cellular response to ATP (GO:0071318)2.56738762
165head development (GO:0060322)2.55569600
166sphingoid metabolic process (GO:0046519)2.55395250
167mesenchymal cell differentiation involved in kidney development (GO:0072161)2.53041295
168mesenchymal cell differentiation involved in renal system development (GO:2001012)2.53041295
169cranial nerve structural organization (GO:0021604)2.49677693
170artery smooth muscle contraction (GO:0014824)2.49634962
171diol metabolic process (GO:0034311)2.48765962
172regulation of respiratory system process (GO:0044065)2.48494729
173cell proliferation in forebrain (GO:0021846)2.48262670
174positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.46042467
175developmental pigmentation (GO:0048066)2.45760313
176positive regulation of odontogenesis (GO:0042482)2.44657655
177glycolipid biosynthetic process (GO:0009247)2.44508269
178regulation of respiratory gaseous exchange (GO:0043576)2.43489563
179positive regulation of dendritic spine morphogenesis (GO:0061003)2.43327696
180regulation of synapse assembly (GO:0051963)2.42377601
181spinal cord association neuron differentiation (GO:0021527)2.41645653
182positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.41614353
183regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.41330209
184cyclic nucleotide catabolic process (GO:0009214)2.40698484
185neuronal ion channel clustering (GO:0045161)2.39755439
186forebrain neuron differentiation (GO:0021879)2.39249326
187histone H2B ubiquitination (GO:0033523)2.35392072
188response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.34155174
189tonic smooth muscle contraction (GO:0014820)2.33965622
190epithelial cilium movement (GO:0003351)2.33260578
191positive regulation of digestive system process (GO:0060456)2.33253682
192amino sugar catabolic process (GO:0046348)2.33045592
193spinal cord motor neuron differentiation (GO:0021522)2.32998790
194adenosine metabolic process (GO:0046085)2.32995725
195glycerophospholipid catabolic process (GO:0046475)2.32332897
196response to redox state (GO:0051775)2.31969095

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.96740402
2GBX2_23144817_ChIP-Seq_PC3_Human3.84830377
3EGR1_23403033_ChIP-Seq_LIVER_Mouse3.38028781
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.35726812
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.70491671
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.49267706
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.47705752
8BMI1_23680149_ChIP-Seq_NPCS_Mouse2.44457190
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.39008045
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.31190873
11TAF15_26573619_Chip-Seq_HEK293_Human2.29796563
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.28836438
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.22446960
14CBX2_27304074_Chip-Seq_ESCs_Mouse2.22355222
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.21616170
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.18179638
17PCGF2_27294783_Chip-Seq_ESCs_Mouse2.17621847
18LXR_22158963_ChIP-Seq_LIVER_Mouse2.10995726
19IGF1R_20145208_ChIP-Seq_DFB_Human2.10592622
20EZH2_18974828_ChIP-Seq_MESCs_Mouse2.10241434
21RNF2_18974828_ChIP-Seq_MESCs_Mouse2.10241434
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.06536814
23FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.04817614
24JARID2_20075857_ChIP-Seq_MESCs_Mouse2.01371901
25FLI1_27457419_Chip-Seq_LIVER_Mouse2.01145514
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.96779529
27RXR_22158963_ChIP-Seq_LIVER_Mouse1.94183092
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.89360446
29SUZ12_27294783_Chip-Seq_NPCs_Mouse1.87920590
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.86584503
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.84573026
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.80040665
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78562108
34BCAT_22108803_ChIP-Seq_LS180_Human1.77329431
35NFE2_27457419_Chip-Seq_LIVER_Mouse1.77109617
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.77041702
37P300_19829295_ChIP-Seq_ESCs_Human1.74339412
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.73184188
39MTF2_20144788_ChIP-Seq_MESCs_Mouse1.72430453
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72187308
41E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.71675488
42VDR_22108803_ChIP-Seq_LS180_Human1.71413707
43RNF2_27304074_Chip-Seq_ESCs_Mouse1.70748100
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.70183671
45ZNF274_21170338_ChIP-Seq_K562_Hela1.68833177
46SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.68376923
47AR_21572438_ChIP-Seq_LNCaP_Human1.68197835
48SUZ12_27294783_Chip-Seq_ESCs_Mouse1.68005498
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.67871726
50EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.65271184
51TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.62691690
52NANOG_18555785_Chip-Seq_ESCs_Mouse1.62055017
53RNF2_27304074_Chip-Seq_NSC_Mouse1.60390824
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.59079240
55TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57701719
56DROSHA_22980978_ChIP-Seq_HELA_Human1.56584237
57SMAD4_21799915_ChIP-Seq_A2780_Human1.55570321
58NR3C1_21868756_ChIP-Seq_MCF10A_Human1.55025412
59E2F1_18555785_Chip-Seq_ESCs_Mouse1.54531924
60PPARA_22158963_ChIP-Seq_LIVER_Mouse1.54492672
61RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.54131029
62P53_22387025_ChIP-Seq_ESCs_Mouse1.52648879
63SUZ12_18555785_Chip-Seq_ESCs_Mouse1.51586478
64FUS_26573619_Chip-Seq_HEK293_Human1.49649573
65EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.49580572
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.48919495
67NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.48861092
68EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.48188425
69PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45700717
70TCF4_22108803_ChIP-Seq_LS180_Human1.45274438
71KLF5_20875108_ChIP-Seq_MESCs_Mouse1.43410892
72P300_18555785_Chip-Seq_ESCs_Mouse1.43032791
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42200365
74* REST_21632747_ChIP-Seq_MESCs_Mouse1.41572873
75UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41360648
76CMYC_18555785_Chip-Seq_ESCs_Mouse1.40207109
77NMYC_18555785_Chip-Seq_ESCs_Mouse1.37080012
78ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.36805802
79STAT3_18555785_Chip-Seq_ESCs_Mouse1.36157156
80TP53_18474530_ChIP-ChIP_U2OS_Human1.35578073
81OCT4_18555785_Chip-Seq_ESCs_Mouse1.34888414
82CBP_20019798_ChIP-Seq_JUKART_Human1.34623904
83IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34623904
84CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.33852077
85RUNX1_27457419_Chip-Seq_LIVER_Mouse1.33007613
86SALL1_21062744_ChIP-ChIP_HESCs_Human1.32825273
87TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32382759
88CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30726039
89CDX2_22108803_ChIP-Seq_LS180_Human1.30231279
90KLF4_18555785_Chip-Seq_ESCs_Mouse1.30187987
91SOX2_18555785_Chip-Seq_ESCs_Mouse1.30172158
92HTT_18923047_ChIP-ChIP_STHdh_Human1.28215830
93ZFX_18555785_Chip-Seq_ESCs_Mouse1.28147064
94TAL1_26923725_Chip-Seq_HPCs_Mouse1.26981578
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26789405
96TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26789405
97REST_18959480_ChIP-ChIP_MESCs_Mouse1.26296585
98CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.25737992
99ESRRB_18555785_Chip-Seq_ESCs_Mouse1.25196033
100SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24447633
101BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.24329223
102STAT3_23295773_ChIP-Seq_U87_Human1.23445320
103MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22824063
104KDM2B_26808549_Chip-Seq_REH_Human1.22568077
105AUTS2_25519132_ChIP-Seq_293T-REX_Human1.22517942
106PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.22371793
107CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.22362290
108CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.22339870
109NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.21933691
110ER_23166858_ChIP-Seq_MCF-7_Human1.21459663
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21269918
112PU1_27457419_Chip-Seq_LIVER_Mouse1.21096064
113RUNX2_22187159_ChIP-Seq_PCA_Human1.19548725
114SMAD1_18555785_Chip-Seq_ESCs_Mouse1.18061499
115CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.16697178
116TP53_16413492_ChIP-PET_HCT116_Human1.16580748
117TCF4_23295773_ChIP-Seq_U87_Human1.16316090
118AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16182392
119CTCF_18555785_Chip-Seq_ESCs_Mouse1.16070926
120OCT4_21477851_ChIP-Seq_ESCs_Mouse1.15642018
121TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14901945
122OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14693012
123SOX2_19829295_ChIP-Seq_ESCs_Human1.13972698
124NANOG_19829295_ChIP-Seq_ESCs_Human1.13972698
125CRX_20693478_ChIP-Seq_RETINA_Mouse1.13428151
126POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11929723
127AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.10486966
128TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09793558
129SOX2_21211035_ChIP-Seq_LN229_Gbm1.09212424
130IKZF1_21737484_ChIP-ChIP_HCT116_Human1.07559642
131FOXH1_21741376_ChIP-Seq_EPCs_Human1.07155430
132AR_25329375_ChIP-Seq_VCAP_Human1.06151235
133KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04781758
134ARNT_22903824_ChIP-Seq_MCF-7_Human1.04641273
135AHR_22903824_ChIP-Seq_MCF-7_Human1.04056684
136FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01881317
137ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01762432
138SMAD4_21741376_ChIP-Seq_EPCs_Human1.01236256
139SMAD3_21741376_ChIP-Seq_HESCs_Human0.99971966
140NOTCH1_21737748_ChIP-Seq_TLL_Human0.99645135
141PRDM14_20953172_ChIP-Seq_ESCs_Human0.98239277
142VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97921549
143CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97911460

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.73710504
2MP0003195_calcinosis5.09783635
3MP0005085_abnormal_gallbladder_physiolo4.12633678
4MP0003880_abnormal_central_pattern3.86695256
5MP0001188_hyperpigmentation3.85190913
6MP0005365_abnormal_bile_salt3.78446835
7MP0008875_abnormal_xenobiotic_pharmacok3.73211025
8MP0002138_abnormal_hepatobiliary_system3.56972102
9MP0005360_urolithiasis3.29976742
10MP0003136_yellow_coat_color3.24795352
11MP0006292_abnormal_olfactory_placode3.23343742
12MP0002102_abnormal_ear_morphology2.73055011
13MP0009053_abnormal_anal_canal2.62523467
14MP0005423_abnormal_somatic_nervous2.62468297
15MP0005409_darkened_coat_color2.59288445
16MP0009379_abnormal_foot_pigmentation2.58700508
17MP0001486_abnormal_startle_reflex2.57121820
18MP0003252_abnormal_bile_duct2.56971418
19MP0004742_abnormal_vestibular_system2.21330461
20MP0004381_abnormal_hair_follicle2.20089718
21MP0003868_abnormal_feces_composition2.19439074
22MP0010329_abnormal_lipoprotein_level2.17506018
23MP0000566_synostosis2.16652316
24MP0008004_abnormal_stomach_pH2.11341353
25MP0005551_abnormal_eye_electrophysiolog2.06230892
26MP0001968_abnormal_touch/_nociception2.05981332
27MP0006072_abnormal_retinal_apoptosis2.00934401
28MP0009697_abnormal_copulation1.99010741
29MP0009745_abnormal_behavioral_response1.97974966
30MP0006276_abnormal_autonomic_nervous1.95196989
31MP0002735_abnormal_chemical_nociception1.94549581
32MP0003646_muscle_fatigue1.93889024
33MP0001501_abnormal_sleep_pattern1.86880173
34MP0005332_abnormal_amino_acid1.85676094
35MP0003938_abnormal_ear_development1.84610990
36MP0001984_abnormal_olfaction1.84355262
37MP0004270_analgesia1.84239885
38MP0009046_muscle_twitch1.82408714
39MP0003787_abnormal_imprinting1.80453927
40MP0000462_abnormal_digestive_system1.78942043
41MP0003635_abnormal_synaptic_transmissio1.78881763
42MP0005451_abnormal_body_composition1.78351887
43MP0000026_abnormal_inner_ear1.77357927
44MP0001485_abnormal_pinna_reflex1.76227819
45MP0002736_abnormal_nociception_after1.75531975
46MP0010386_abnormal_urinary_bladder1.73234154
47MP0002272_abnormal_nervous_system1.72319587
48MP0004859_abnormal_synaptic_plasticity1.71980792
49MP0001440_abnormal_grooming_behavior1.66988923
50MP0002572_abnormal_emotion/affect_behav1.62634600
51MP0002249_abnormal_larynx_morphology1.62049014
52MP0010368_abnormal_lymphatic_system1.60498500
53MP0001666_abnormal_nutrient_absorption1.56813927
54MP0005379_endocrine/exocrine_gland_phen1.56723755
55MP0002277_abnormal_respiratory_mucosa1.54278010
56MP0004142_abnormal_muscle_tone1.53460551
57MP0002734_abnormal_mechanical_nocicepti1.51036423
58MP0002909_abnormal_adrenal_gland1.50449554
59MP0008872_abnormal_physiological_respon1.50377960
60MP0002067_abnormal_sensory_capabilities1.48803554
61MP0005253_abnormal_eye_physiology1.48526045
62MP0002064_seizures1.47667084
63MP0005645_abnormal_hypothalamus_physiol1.44977063
64MP0001963_abnormal_hearing_physiology1.44359035
65MP0008995_early_reproductive_senescence1.43155976
66MP0005174_abnormal_tail_pigmentation1.40228267
67MP0002118_abnormal_lipid_homeostasis1.38982243
68MP0005171_absent_coat_pigmentation1.38164031
69MP0001764_abnormal_homeostasis1.37792486
70MP0002557_abnormal_social/conspecific_i1.37386779
71MP0000778_abnormal_nervous_system1.36578900
72MP0002638_abnormal_pupillary_reflex1.35500932
73MP0000049_abnormal_middle_ear1.34580377
74MP0002752_abnormal_somatic_nervous1.32537262
75MP0003941_abnormal_skin_development1.31358335
76MP0002063_abnormal_learning/memory/cond1.31220015
77MP0001986_abnormal_taste_sensitivity1.29732777
78MP0000383_abnormal_hair_follicle1.25916123
79MP0005670_abnormal_white_adipose1.18163023
80MP0002733_abnormal_thermal_nociception1.14485157
81MP0000015_abnormal_ear_pigmentation1.13955766
82MP0003950_abnormal_plasma_membrane1.10169302
83MP0005410_abnormal_fertilization1.10069890
84MP0000631_abnormal_neuroendocrine_gland1.09640450
85MP0001970_abnormal_pain_threshold1.09276110
86MP0002184_abnormal_innervation1.08518169
87MP0001664_abnormal_digestion1.07880589
88MP0004145_abnormal_muscle_electrophysio1.03961766
89MP0000538_abnormal_urinary_bladder1.00122684
90MP0004019_abnormal_vitamin_homeostasis0.99880670
91MP0000579_abnormal_nail_morphology0.99508526
92MP0002882_abnormal_neuron_morphology0.98195445
93MP0001661_extended_life_span0.97942129
94MP0000762_abnormal_tongue_morphology0.96765572
95MP0003633_abnormal_nervous_system0.96212026
96MP0002090_abnormal_vision0.95547470
97MP0005195_abnormal_posterior_eye0.94860571
98MP0001529_abnormal_vocalization0.94062279
99MP0002876_abnormal_thyroid_physiology0.93739807
100MP0002234_abnormal_pharynx_morphology0.91264061
101MP0000609_abnormal_liver_physiology0.90849424
102MP0005646_abnormal_pituitary_gland0.90704581
103MP0003879_abnormal_hair_cell0.90295301
104MP0000427_abnormal_hair_cycle0.89750020
105MP0000613_abnormal_salivary_gland0.88619444
106MP0002229_neurodegeneration0.87770456
107MP0004043_abnormal_pH_regulation0.87464280
108MP0003315_abnormal_perineum_morphology0.85076363
109MP0005595_abnormal_vascular_smooth0.85048415
110MP0003718_maternal_effect0.84849492
111MP0000678_abnormal_parathyroid_gland0.83746351
112MP0004484_altered_response_of0.83727774
113MP0003011_delayed_dark_adaptation0.82672600
114MP0002098_abnormal_vibrissa_morphology0.82298345
115MP0005310_abnormal_salivary_gland0.81689406
116MP0003283_abnormal_digestive_organ0.80958625
117MP0004133_heterotaxia0.80305154
118MP0003690_abnormal_glial_cell0.79803184
119MP0001346_abnormal_lacrimal_gland0.77322579
120MP0008874_decreased_physiological_sensi0.77190545
121MP0005408_hypopigmentation0.75810180
122MP0005395_other_phenotype0.75803934
123MP0010678_abnormal_skin_adnexa0.75689755
124MP0005381_digestive/alimentary_phenotyp0.75555843
125MP0001905_abnormal_dopamine_level0.75482335
126MP0000920_abnormal_myelination0.75460006
127MP0002233_abnormal_nose_morphology0.74624255
128MP0002066_abnormal_motor_capabilities/c0.74208857
129MP0005391_vision/eye_phenotype0.74059106
130MP0004885_abnormal_endolymph0.73540811
131MP0003878_abnormal_ear_physiology0.72699252
132MP0005377_hearing/vestibular/ear_phenot0.72699252
133MP0000955_abnormal_spinal_cord0.72194076
134MP0008260_abnormal_autophagy0.71995222
135MP0005636_abnormal_mineral_homeostasis0.71024411
136MP0005167_abnormal_blood-brain_barrier0.70770861
137MP0004130_abnormal_muscle_cell0.70684241
138MP0002938_white_spotting0.70568427
139MP0000467_abnormal_esophagus_morphology0.69424453
140MP0000647_abnormal_sebaceous_gland0.69129269
141MP0004510_myositis0.66567889
142MP0004233_abnormal_muscle_weight0.65720126
143MP0003631_nervous_system_phenotype0.64847182
144MP0003115_abnormal_respiratory_system0.64550782
145MP0002971_abnormal_brown_adipose0.64465817
146MP0009780_abnormal_chondrocyte_physiolo0.63691627
147MP0003698_abnormal_male_reproductive0.59310880
148MP0009764_decreased_sensitivity_to0.58982741
149MP0009643_abnormal_urine_homeostasis0.56979517
150MP0009115_abnormal_fat_cell0.55957222
151MP0005535_abnormal_body_temperature0.55305821

Predicted human phenotypes

RankGene SetZ-score
1Complement deficiency (HP:0004431)5.44102956
2Abnormality of monocarboxylic acid metabolism (HP:0010996)5.13529866
3Abnormality of aromatic amino acid family metabolism (HP:0004338)4.85898038
4Prolonged partial thromboplastin time (HP:0003645)4.83755992
5Deep venous thrombosis (HP:0002625)4.70222702
6Duplicated collecting system (HP:0000081)4.57769103
7Hypobetalipoproteinemia (HP:0003563)4.45178208
8Chromosomal breakage induced by crosslinking agents (HP:0003221)4.44168829
9Abnormality of the renal collecting system (HP:0004742)4.29661047
10Abnormality of macular pigmentation (HP:0008002)4.20088929
11Hyperlipoproteinemia (HP:0010980)4.16506746
12Abnormality of complement system (HP:0005339)4.03161312
13Upper limb muscle weakness (HP:0003484)3.99762853
14Conjugated hyperbilirubinemia (HP:0002908)3.90288063
15Hyperglycinuria (HP:0003108)3.89003518
16Absent/shortened dynein arms (HP:0200106)3.87171340
17Dynein arm defect of respiratory motile cilia (HP:0012255)3.87171340
18Chromsome breakage (HP:0040012)3.81567087
19Decreased central vision (HP:0007663)3.75648462
20Abnormality of glycine metabolism (HP:0010895)3.73232255
21Abnormality of serine family amino acid metabolism (HP:0010894)3.73232255
22Systemic lupus erythematosus (HP:0002725)3.73182882
23Abnormal ciliary motility (HP:0012262)3.71022721
24Hyperglycinemia (HP:0002154)3.64278213
25Focal motor seizures (HP:0011153)3.62878485
26Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.48594575
27Spontaneous abortion (HP:0005268)3.43063538
28Intrahepatic cholestasis (HP:0001406)3.42982422
29Joint hemorrhage (HP:0005261)3.40483937
30Tubulointerstitial nephritis (HP:0001970)3.38913567
31Febrile seizures (HP:0002373)3.36944142
32Congenital sensorineural hearing impairment (HP:0008527)3.35561381
33Abnormality of methionine metabolism (HP:0010901)3.25832324
34Congenital stationary night blindness (HP:0007642)3.22918720
35Septo-optic dysplasia (HP:0100842)3.09223518
36Abnormal respiratory motile cilium physiology (HP:0012261)3.05384181
37Mitral stenosis (HP:0001718)3.02622362
38Status epilepticus (HP:0002133)2.95683020
39Abnormality of glutamine family amino acid metabolism (HP:0010902)2.92821436
40Hemorrhage of the eye (HP:0011885)2.91216682
41Duplication of thumb phalanx (HP:0009942)2.90985429
42Abnormality of proline metabolism (HP:0010907)2.89943321
43Hydroxyprolinuria (HP:0003080)2.89943321
44Glomerulonephritis (HP:0000099)2.87136687
45Abnormal rod and cone electroretinograms (HP:0008323)2.85699597
46Abnormal respiratory epithelium morphology (HP:0012253)2.84090770
47Abnormal respiratory motile cilium morphology (HP:0005938)2.84090770
48Aplasia cutis congenita (HP:0001057)2.82814677
49Pendular nystagmus (HP:0012043)2.82247705
50Abnormality of aspartate family amino acid metabolism (HP:0010899)2.81314174
51Xanthomatosis (HP:0000991)2.80330726
52Epidermoid cyst (HP:0200040)2.79691981
53Nephritis (HP:0000123)2.72408810
54Abnormal biliary tract physiology (HP:0012439)2.71769019
55Bile duct proliferation (HP:0001408)2.71769019
56Abnormality of binocular vision (HP:0011514)2.65979086
57Diplopia (HP:0000651)2.65979086
58Atonic seizures (HP:0010819)2.64465783
59Vascular calcification (HP:0004934)2.64119537
60Abnormality of the common coagulation pathway (HP:0010990)2.62424144
61Gait imbalance (HP:0002141)2.61978359
62Ketosis (HP:0001946)2.58016741
63Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.57812042
64Overfolded helix (HP:0000396)2.53825279
65Bony spicule pigmentary retinopathy (HP:0007737)2.51873850
66Ketoacidosis (HP:0001993)2.51606465
67Facial shape deformation (HP:0011334)2.51349151
68Potter facies (HP:0002009)2.51349151
69Nasolacrimal duct obstruction (HP:0000579)2.50787310
70Abnormality of secondary sexual hair (HP:0009888)2.47237435
71Abnormality of the axillary hair (HP:0100134)2.47237435
72Medial flaring of the eyebrow (HP:0010747)2.46707708
73Fair hair (HP:0002286)2.45258846
74Attenuation of retinal blood vessels (HP:0007843)2.45252927
75Recurrent pneumonia (HP:0006532)2.44898890
76Atelectasis (HP:0100750)2.44841339
77Congenital primary aphakia (HP:0007707)2.44114096
78Hypolipoproteinemia (HP:0010981)2.42906552
79Abnormality of the intrinsic pathway (HP:0010989)2.42866030
80Poikiloderma (HP:0001029)2.42046102
81Oligodactyly (hands) (HP:0001180)2.41351704
82Anal stenosis (HP:0002025)2.41101219
83Absent rod-and cone-mediated responses on ERG (HP:0007688)2.38587866
84Methylmalonic acidemia (HP:0002912)2.38486944
85Abnormality of the renal medulla (HP:0100957)2.38288252
86Abnormality of DNA repair (HP:0003254)2.37101143
87Osteomalacia (HP:0002749)2.36101767
88Dyschromatopsia (HP:0007641)2.34920809
89Hyperammonemia (HP:0001987)2.33397440
90Parakeratosis (HP:0001036)2.31915543
91Abnormality of sulfur amino acid metabolism (HP:0004339)2.31721896
92Nephronophthisis (HP:0000090)2.26903268
93Nephrogenic diabetes insipidus (HP:0009806)2.26874135
94Dialeptic seizures (HP:0011146)2.26386679
95Retinal atrophy (HP:0001105)2.26186525
96Decreased electroretinogram (ERG) amplitude (HP:0000654)2.24342674
97Epileptic encephalopathy (HP:0200134)2.23466707
98Methylmalonic aciduria (HP:0012120)2.22169293
99Cardiovascular calcification (HP:0011915)2.22143985
100Abnormality of the lacrimal duct (HP:0011481)2.21513550
101Abnormality of serum amino acid levels (HP:0003112)2.20654026
102Degeneration of the lateral corticospinal tracts (HP:0002314)2.20406074
103Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.20406074
104Pheochromocytoma (HP:0002666)2.20160184
105Genital tract atresia (HP:0001827)2.19230973
106Horizontal nystagmus (HP:0000666)2.19038608
107Renal agenesis (HP:0000104)2.18572323
108Generalized aminoaciduria (HP:0002909)2.18042959
109Vaginal atresia (HP:0000148)2.17486042
110Absence seizures (HP:0002121)2.17361400
111Thyroid-stimulating hormone excess (HP:0002925)2.17027811
112Broad foot (HP:0001769)2.16734905
113Fat malabsorption (HP:0002630)2.15086860
114Hemiparesis (HP:0001269)2.14939492
115Abnormally folded helix (HP:0008544)2.14613619
116Broad-based gait (HP:0002136)2.14547462
117Hypophosphatemic rickets (HP:0004912)2.12903849
118Reticulocytopenia (HP:0001896)2.12624402
119Renal cortical cysts (HP:0000803)2.11930469
120Metabolic alkalosis (HP:0200114)2.09890128
121Neoplasm of the heart (HP:0100544)2.08984917
122Absent septum pellucidum (HP:0001331)2.08980961
123Optic nerve hypoplasia (HP:0000609)2.08967728
124Abnormality of vitamin metabolism (HP:0100508)2.08197606
125Confusion (HP:0001289)2.08151869
126Focal seizures (HP:0007359)2.07571169
127Arthropathy (HP:0003040)2.07309447
128Neuroendocrine neoplasm (HP:0100634)2.07269995
129Abnormality of pyrimidine metabolism (HP:0004353)2.05299003
130Absent speech (HP:0001344)2.03477017
131Atrioventricular block (HP:0001678)2.03084801
132Stage 5 chronic kidney disease (HP:0003774)2.03022952
133Macular degeneration (HP:0000608)2.02959034
134Abnormality of the septum pellucidum (HP:0007375)2.01742799
135Abnormality of the nasolacrimal system (HP:0000614)1.99490031
136Congenital, generalized hypertrichosis (HP:0004540)1.99232238
137Abolished electroretinogram (ERG) (HP:0000550)1.98558771
138Hyperkalemia (HP:0002153)1.98001830
139Male pseudohermaphroditism (HP:0000037)1.95442450
140Generalized hypopigmentation of hair (HP:0011358)1.94184975
141Proximal tubulopathy (HP:0000114)1.93923597
142Stenosis of the external auditory canal (HP:0000402)1.93849016
143Morphological abnormality of the middle ear (HP:0008609)1.93615335
144Tubulointerstitial abnormality (HP:0001969)1.93435113
145Generalized tonic-clonic seizures (HP:0002069)1.91920045
146Clumsiness (HP:0002312)1.90397953
147Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.90048647
148White forelock (HP:0002211)1.89287020
149Chronic hepatic failure (HP:0100626)1.89224067
150Steatorrhea (HP:0002570)1.87610970
151Abnormality of the fovea (HP:0000493)1.87443629
152Absent radius (HP:0003974)1.85638021
153Menorrhagia (HP:0000132)1.84904509
154Congenital hepatic fibrosis (HP:0002612)1.84580171
155Aplasia involving forearm bones (HP:0009822)1.84059231
156Absent forearm bone (HP:0003953)1.84059231
157Xerostomia (HP:0000217)1.83468848
158Neurofibrillary tangles (HP:0002185)1.82670213
159Lethargy (HP:0001254)1.81047182
160Increased corneal curvature (HP:0100692)1.79194408
161Keratoconus (HP:0000563)1.79194408
162Abnormality of the preputium (HP:0100587)1.76870134
163Abnormality of salivation (HP:0100755)1.75999097
164Conjunctival telangiectasia (HP:0000524)1.75949261
165Generalized myoclonic seizures (HP:0002123)1.75914216
166Gingival bleeding (HP:0000225)1.74903701
167Abnormality of the vitamin B12 metabolism (HP:0004341)1.73837591
168Abnormality of the renal cortex (HP:0011035)1.73016304
169Gastroesophageal reflux (HP:0002020)1.73007829
170Median cleft lip (HP:0000161)1.72907575
171Patchy hypopigmentation of hair (HP:0011365)1.72336909
172Excessive salivation (HP:0003781)1.72264222
173Drooling (HP:0002307)1.72264222
174Choroideremia (HP:0001139)1.71513658
175Poor coordination (HP:0002370)1.71477362
176Rickets (HP:0002748)1.71392348
177Mesomelia (HP:0003027)1.71038238
178Blue irides (HP:0000635)1.70353705
179Aplasia/Hypoplasia of the lens (HP:0008063)1.70128852
180Neonatal respiratory distress (HP:0002643)1.69947433
181Exotropia (HP:0000577)1.69632834
182Fetal akinesia sequence (HP:0001989)1.69282353
183Conical tooth (HP:0000698)1.69169735
184Retinal dysplasia (HP:0007973)1.69004322
185Hyperventilation (HP:0002883)1.67626460
186Cupped ear (HP:0000378)1.67527154
187Anomalous pulmonary venous return (HP:0010772)1.66961101
188Chin dimple (HP:0010751)1.66768215
189Anal atresia (HP:0002023)1.66538893
190Decreased lacrimation (HP:0000633)1.65090128
191Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.61853558

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.50672119
2CASK4.34028919
3PDK24.24126121
4BLK3.97812828
5TNIK3.94612511
6STK163.30817799
7ERBB42.79272978
8GRK12.67080844
9IRAK32.62319793
10INSRR2.53312605
11NTRK32.40296283
12EPHA42.36141237
13STK392.08367963
14PIK3CG1.95555541
15EIF2AK21.93973060
16RIPK41.80654205
17IRAK21.72613622
18PKN11.66376854
19IRAK11.65610713
20ICK1.62292916
21TAOK31.61750291
22NEK61.58780073
23PBK1.57711623
24MKNK21.55725678
25OXSR11.54421930
26SRPK11.49839656
27PNCK1.43491389
28SIK21.42781853
29BCR1.41690412
30GRK71.38469380
31ADRBK21.35820065
32NUAK11.34322017
33MAPK131.33522861
34FGR1.31220184
35FES1.24105171
36IRAK41.22167693
37TLK11.17951035
38ERBB21.14568758
39TNK21.11504506
40PINK11.07128577
41MAP2K71.06199648
42BMPR21.04244416
43PRKD31.00325846
44CAMK2B0.95650335
45CSNK1G20.94280551
46NTRK20.94225558
47MAPK150.94185668
48NME10.93365098
49AKT30.93176877
50PIK3CA0.92266152
51MAP3K90.90078653
52MARK10.89345359
53WNK40.89298955
54CAMK2A0.88964495
55YES10.88361767
56MAP3K60.87979147
57MATK0.87526696
58PRKCE0.87134797
59CAMK1G0.86387989
60BMPR1B0.83868466
61MAPK70.82625908
62MAPK110.81960288
63PTK2B0.78858836
64CSNK1G30.78307107
65CLK10.77232192
66CDK30.77164540
67CSNK1G10.74588627
68WNK10.73836378
69MAP3K130.72335982
70MKNK10.71158475
71CDC42BPA0.70957446
72EPHB20.70762172
73CAMK10.67992517
74CAMK2D0.67754998
75SGK10.64972095
76WNK30.64295444
77DAPK20.63675293
78FER0.63245990
79MAP3K40.61909682
80MARK20.61404611
81MAPK120.60831973
82PRKD20.60755925
83DYRK20.60399793
84PRKCQ0.59070579
85PRKAA20.59060940
86CSNK1D0.58810653
87PRKG10.58785883
88GRK50.57274372
89MAP3K140.55417097
90PDK10.55059998
91PLK40.55017940
92BRD40.54449477
93DYRK1A0.53250117
94TTK0.50166116
95PLK20.49790141
96STK38L0.48375940
97PRKCG0.47501710
98PRKACA0.47423024
99PRKCZ0.47402630
100MAPKAPK50.46563275
101PRKACG0.46553545
102PAK30.46202295
103TXK0.45572187
104DMPK0.45511681
105KIT0.44727471
106STK110.44201929
107MST40.44187366
108FYN0.43865061
109CAMK1D0.43374473
110CDK50.43168500
111ALK0.43102033
112PRKCB0.42752549
113MAP4K20.42736525
114ROCK20.42175780
115CAMK2G0.41837614
116MAP2K40.41633625
117CSNK1A10.41502289
118MAP3K50.41211985
119PAK60.40554200
120NTRK10.40258461
121EPHB10.40026988
122PDPK10.39985004
123LYN0.39961089
124CSNK1E0.39409463
125ADRBK10.38754723
126EPHA30.38691535
127LMTK20.38614393
128ATM0.38457540
129MAP2K60.37482434
130CDK90.36904495
131CSNK1A1L0.35842238
132JAK20.35830208
133STK380.35430895
134UHMK10.34892244
135PRKCA0.33793590
136PRKCH0.33523094
137RPS6KA30.33409295
138MAPK90.32091009
139IGF1R0.30555081
140PRKDC0.29448195
141JAK10.28974640
142INSR0.28968794
143GSK3A0.28441908
144RET0.26625889
145NEK90.26426453
146ABL10.26419593
147SYK0.26272945
148IKBKB0.25755524

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.23834743
2Caffeine metabolism_Homo sapiens_hsa002323.96940809
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.95446026
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.61151056
5Phototransduction_Homo sapiens_hsa047443.27692702
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.04657115
7Complement and coagulation cascades_Homo sapiens_hsa046102.83149840
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.79394254
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.70470526
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.62328987
11Butanoate metabolism_Homo sapiens_hsa006502.52278952
12Chemical carcinogenesis_Homo sapiens_hsa052042.42695621
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.40663725
14Taste transduction_Homo sapiens_hsa047422.35704126
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.35435202
16Morphine addiction_Homo sapiens_hsa050322.35371897
17Pentose and glucuronate interconversions_Homo sapiens_hsa000402.33222552
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.31323983
19Fatty acid degradation_Homo sapiens_hsa000712.22505339
20Glutamatergic synapse_Homo sapiens_hsa047242.18016960
21Tryptophan metabolism_Homo sapiens_hsa003802.16238607
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.03254257
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.02273069
24Salivary secretion_Homo sapiens_hsa049702.02121982
25Phenylalanine metabolism_Homo sapiens_hsa003602.01808088
26Serotonergic synapse_Homo sapiens_hsa047261.99333939
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.97227310
28Fanconi anemia pathway_Homo sapiens_hsa034601.92726917
29Calcium signaling pathway_Homo sapiens_hsa040201.77474908
30Sphingolipid metabolism_Homo sapiens_hsa006001.76072765
31GABAergic synapse_Homo sapiens_hsa047271.72461430
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.68976694
33Glycerolipid metabolism_Homo sapiens_hsa005611.67500140
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.66684192
35Bile secretion_Homo sapiens_hsa049761.65660314
36Tyrosine metabolism_Homo sapiens_hsa003501.61575765
37One carbon pool by folate_Homo sapiens_hsa006701.60243732
38Arginine biosynthesis_Homo sapiens_hsa002201.57597033
39Circadian entrainment_Homo sapiens_hsa047131.57352092
40Ether lipid metabolism_Homo sapiens_hsa005651.53578074
41Axon guidance_Homo sapiens_hsa043601.51418921
42ABC transporters_Homo sapiens_hsa020101.50611502
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.50308398
44Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.48564283
45Peroxisome_Homo sapiens_hsa041461.42616032
46Steroid biosynthesis_Homo sapiens_hsa001001.41764300
47Arachidonic acid metabolism_Homo sapiens_hsa005901.37803548
48Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.37067008
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.36455239
50Amphetamine addiction_Homo sapiens_hsa050311.35175223
51PPAR signaling pathway_Homo sapiens_hsa033201.34503605
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31791829
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.31620293
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.30233399
55Starch and sucrose metabolism_Homo sapiens_hsa005001.26700068
56Propanoate metabolism_Homo sapiens_hsa006401.22636986
57Vitamin digestion and absorption_Homo sapiens_hsa049771.22525236
58Long-term depression_Homo sapiens_hsa047301.21873625
59Renin secretion_Homo sapiens_hsa049241.20880290
60Linoleic acid metabolism_Homo sapiens_hsa005911.19973879
61cAMP signaling pathway_Homo sapiens_hsa040241.18942489
62Insulin secretion_Homo sapiens_hsa049111.18637957
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.18450086
64Gastric acid secretion_Homo sapiens_hsa049711.17911595
65Oxidative phosphorylation_Homo sapiens_hsa001901.14582597
66Pancreatic secretion_Homo sapiens_hsa049721.11939683
67Fatty acid elongation_Homo sapiens_hsa000621.10924963
68Mineral absorption_Homo sapiens_hsa049781.07508249
69Cocaine addiction_Homo sapiens_hsa050301.07077357
70Vascular smooth muscle contraction_Homo sapiens_hsa042701.04863314
71Cholinergic synapse_Homo sapiens_hsa047251.04457627
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03132555
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03051832
74Dopaminergic synapse_Homo sapiens_hsa047281.02876877
75Autoimmune thyroid disease_Homo sapiens_hsa053201.01243937
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.98269665
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.96350551
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.95937745
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.95749639
80Cardiac muscle contraction_Homo sapiens_hsa042600.94878915
81Fatty acid metabolism_Homo sapiens_hsa012120.92860052
82Alzheimers disease_Homo sapiens_hsa050100.92318522
83Nitrogen metabolism_Homo sapiens_hsa009100.90354792
84Non-homologous end-joining_Homo sapiens_hsa034500.89024704
85Pyruvate metabolism_Homo sapiens_hsa006200.88506803
86Other glycan degradation_Homo sapiens_hsa005110.86999281
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.86561400
88Lysine degradation_Homo sapiens_hsa003100.85981771
89Oxytocin signaling pathway_Homo sapiens_hsa049210.84212750
90Ovarian steroidogenesis_Homo sapiens_hsa049130.82843796
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.82775031
92Protein digestion and absorption_Homo sapiens_hsa049740.80566914
93Melanogenesis_Homo sapiens_hsa049160.80144932
94Choline metabolism in cancer_Homo sapiens_hsa052310.79785294
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79632575
96Basal cell carcinoma_Homo sapiens_hsa052170.79629887
97Staphylococcus aureus infection_Homo sapiens_hsa051500.79006143
98African trypanosomiasis_Homo sapiens_hsa051430.76084215
99Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.73616382
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73413271
101Long-term potentiation_Homo sapiens_hsa047200.73327037
102Hedgehog signaling pathway_Homo sapiens_hsa043400.72343302
103Olfactory transduction_Homo sapiens_hsa047400.70316512
104Steroid hormone biosynthesis_Homo sapiens_hsa001400.69573443
105Retinol metabolism_Homo sapiens_hsa008300.69123427
106Ras signaling pathway_Homo sapiens_hsa040140.67825286
107Wnt signaling pathway_Homo sapiens_hsa043100.64966253
108ECM-receptor interaction_Homo sapiens_hsa045120.64165202
109Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.63365110
110Selenocompound metabolism_Homo sapiens_hsa004500.62607293
111Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61927413
112Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61664287
113Dorso-ventral axis formation_Homo sapiens_hsa043200.61142826
114Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60404651
115Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60156820
116Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56966859
117Maturity onset diabetes of the young_Homo sapiens_hsa049500.56838838
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.56115138
119GnRH signaling pathway_Homo sapiens_hsa049120.55643281
120Inositol phosphate metabolism_Homo sapiens_hsa005620.54341550
121Fatty acid biosynthesis_Homo sapiens_hsa000610.52238994
122ErbB signaling pathway_Homo sapiens_hsa040120.51391517
123Type II diabetes mellitus_Homo sapiens_hsa049300.50841308
124Arginine and proline metabolism_Homo sapiens_hsa003300.49384518
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.49354132
126Biosynthesis of amino acids_Homo sapiens_hsa012300.49092620
127Huntingtons disease_Homo sapiens_hsa050160.48903061
128Collecting duct acid secretion_Homo sapiens_hsa049660.47651921
129Dilated cardiomyopathy_Homo sapiens_hsa054140.47124643
130Melanoma_Homo sapiens_hsa052180.46516669
131Fat digestion and absorption_Homo sapiens_hsa049750.45939858
132Histidine metabolism_Homo sapiens_hsa003400.45801039
133Metabolic pathways_Homo sapiens_hsa011000.44601648
134Asthma_Homo sapiens_hsa053100.43879596
135Renin-angiotensin system_Homo sapiens_hsa046140.43637877
136Glycerophospholipid metabolism_Homo sapiens_hsa005640.43390176
137Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42733247
138Rheumatoid arthritis_Homo sapiens_hsa053230.40686656
139Thyroid hormone synthesis_Homo sapiens_hsa049180.39445094
140Rap1 signaling pathway_Homo sapiens_hsa040150.39250771
141Graft-versus-host disease_Homo sapiens_hsa053320.39172405
142Hematopoietic cell lineage_Homo sapiens_hsa046400.37046730
143Glutathione metabolism_Homo sapiens_hsa004800.36132188
144beta-Alanine metabolism_Homo sapiens_hsa004100.35911809
145MAPK signaling pathway_Homo sapiens_hsa040100.35763497
146Sulfur relay system_Homo sapiens_hsa041220.35757293
147Vitamin B6 metabolism_Homo sapiens_hsa007500.33500724
148Prion diseases_Homo sapiens_hsa050200.29233695
149Carbon metabolism_Homo sapiens_hsa012000.26989065
150Sulfur metabolism_Homo sapiens_hsa009200.19685832
1512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.17107899
152Circadian rhythm_Homo sapiens_hsa047100.16189709
153Folate biosynthesis_Homo sapiens_hsa007900.10265552
154Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.09089975
155Pertussis_Homo sapiens_hsa051330.04360383

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