ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of male gonad development (GO:2000020)	7.82971334
2	diaphragm development (GO:0060539)	6.89371750
3	skeletal muscle organ development (GO:0060538)	6.71626564
4	regulation of male gonad development (GO:2000018)	6.08883399
5	negative regulation of metanephros development (GO:0072217)	5.95104607
6	glomerulus development (GO:0032835)	5.71788177
7	pyrimidine nucleobase catabolic process (GO:0006208)	5.69823460
8	metanephric mesenchyme development (GO:0072075)	5.63599139
9	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	5.31366140
10	regulation of female gonad development (GO:2000194)	5.18088217
11	cellular response to gonadotropin stimulus (GO:0071371)	5.17724836
12	cellular response to follicle-stimulating hormone stimulus (GO:0071372)	5.08949674
13	regulation of gonadotropin secretion (GO:0032276)	5.08035516
14	presynaptic membrane assembly (GO:0097105)	4.93218515
15	sex determination (GO:0007530)	4.85706072
16	epithelial cell differentiation involved in kidney development (GO:0035850)	4.84622678
17	kidney mesenchyme development (GO:0072074)	4.80395384
18	detection of temperature stimulus involved in sensory perception (GO:0050961)	4.47137982
19	detection of temperature stimulus involved in sensory perception of pain (GO:0050965)	4.47137982
20	regulation of mesenchymal cell apoptotic process (GO:2001053)	4.45775752
21	regulation of cell proliferation involved in kidney development (GO:1901722)	4.38651821
22	nucleobase catabolic process (GO:0046113)	4.31517976
23	presynaptic membrane organization (GO:0097090)	4.25016510
24	parturition (GO:0007567)	4.24998262
25	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	4.24905314
26	mesonephros development (GO:0001823)	4.20754378
27	muscle cell fate commitment (GO:0042693)	4.06649846
28	glycosphingolipid biosynthetic process (GO:0006688)	4.04223092
29	regulation of glomerulus development (GO:0090192)	3.99305240
30	glomerular basement membrane development (GO:0032836)	3.92089036
31	seminiferous tubule development (GO:0072520)	3.86383020
32	cardiac right ventricle morphogenesis (GO:0003215)	3.84698496
33	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.80832308
34	response to gonadotropin (GO:0034698)	3.80094905
35	postsynaptic membrane organization (GO:0001941)	3.76288487
36	mesenchymal to epithelial transition (GO:0060231)	3.75966066
37	embryonic digestive tract morphogenesis (GO:0048557)	3.75133682
38	negative regulation of kidney development (GO:0090185)	3.74628200
39	regulation of cardioblast differentiation (GO:0051890)	3.73774176
40	dendritic spine morphogenesis (GO:0060997)	3.66164878
41	endocardial cushion development (GO:0003197)	3.59619426
42	response to follicle-stimulating hormone (GO:0032354)	3.56857857
43	embryonic foregut morphogenesis (GO:0048617)	3.53679573
44	neuron cell-cell adhesion (GO:0007158)	3.44318569
45	short-term memory (GO:0007614)	3.42166247
46	detection of temperature stimulus (GO:0016048)	3.40754948
47	regulation of synapse structural plasticity (GO:0051823)	3.40579394
48	olfactory bulb development (GO:0021772)	3.39900035
49	negative regulation of macrophage differentiation (GO:0045650)	3.38619789
50	central nervous system projection neuron axonogenesis (GO:0021952)	3.31370266
51	metanephric epithelium development (GO:0072207)	3.31272074
52	protein localization to synapse (GO:0035418)	3.28215581
53	nonmotile primary cilium assembly (GO:0035058)	3.21805403
54	positive regulation of heart growth (GO:0060421)	3.17504878
55	prenylation (GO:0097354)	3.11541398
56	protein prenylation (GO:0018342)	3.11541398
57	neural tube formation (GO:0001841)	3.10721189
58	behavioral response to nicotine (GO:0035095)	3.07941145
59	regulation of cardiac muscle cell contraction (GO:0086004)	3.01863803
60	vitamin A metabolic process (GO:0006776)	2.99647595
61	positive regulation of metanephros development (GO:0072216)	2.96301724
62	limb bud formation (GO:0060174)	2.93124592
63	gastrulation with mouth forming second (GO:0001702)	2.90700606
64	sex differentiation (GO:0007548)	2.89643635
65	somite development (GO:0061053)	2.88295610
66	central nervous system neuron axonogenesis (GO:0021955)	2.85252233
67	cornea development in camera-type eye (GO:0061303)	2.83632844
68	regulation of cAMP-dependent protein kinase activity (GO:2000479)	2.83530638
69	neurotransmitter catabolic process (GO:0042135)	2.83367246
70	anatomical structure regression (GO:0060033)	2.83367105
71	sialylation (GO:0097503)	2.80956192
72	male sex determination (GO:0030238)	2.80350739
73	hindbrain development (GO:0030902)	2.79588876
74	neurotransmitter-gated ion channel clustering (GO:0072578)	2.75155044
75	layer formation in cerebral cortex (GO:0021819)	2.74319919
76	cilium morphogenesis (GO:0060271)	2.74299144
77	gamma-aminobutyric acid transport (GO:0015812)	2.73591260
78	cell differentiation involved in kidney development (GO:0061005)	2.72058961
79	endoderm formation (GO:0001706)	2.70178753
80	synapse assembly (GO:0007416)	2.68771886
81	cellular response to leptin stimulus (GO:0044320)	2.68559827
82	dorsal/ventral neural tube patterning (GO:0021904)	2.68308830
83	SMAD protein signal transduction (GO:0060395)	2.68079973
84	protein localization to cilium (GO:0061512)	2.67378718
85	positive regulation of mesonephros development (GO:0061213)	2.65785189
86	male genitalia development (GO:0030539)	2.65456235
87	proline transport (GO:0015824)	2.63531679
88	galactose catabolic process (GO:0019388)	2.63055552
89	regulation of cilium movement (GO:0003352)	2.61834770
90	vocalization behavior (GO:0071625)	2.57608287
91	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.57332248
92	ganglioside metabolic process (GO:0001573)	2.57261676
93	dendrite morphogenesis (GO:0048813)	2.53880476
94	dendrite development (GO:0016358)	2.53686917
95	regulation of collateral sprouting (GO:0048670)	2.53563373
96	anterograde axon cargo transport (GO:0008089)	2.52019756
97	regulation of development, heterochronic (GO:0040034)	2.50873574
98	metanephros development (GO:0001656)	2.48718070
99	dopamine biosynthetic process (GO:0042416)	2.47448502
100	branching involved in ureteric bud morphogenesis (GO:0001658)	2.46990481

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.21863873
2	GBX2_23144817_ChIP-Seq_PC3_Human	2.80299238
3	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.70952732
4	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.70414355
5	RNF2_27304074_Chip-Seq_NSC_Mouse	2.64225087
6	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.56039057
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.52058473
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.49614687
9	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.45146233
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.44761328
11	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.41064147
12	IGF1R_20145208_ChIP-Seq_DFB_Human	2.38289499
13	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.31945724
14	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.25003114
15	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.24914884
16	TAF15_26573619_Chip-Seq_HEK293_Human	2.21449818
17	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.20620374
18	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.09101009
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.02464046
20	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.96867975
21	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.96867975
22	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.95304675
23	EWS_26573619_Chip-Seq_HEK293_Human	1.93972839
24	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.90727258
25	AR_21572438_ChIP-Seq_LNCaP_Human	1.89350245
26	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.88709605
27	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.82388896
28	VDR_22108803_ChIP-Seq_LS180_Human	1.81121604
29	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.80257000
30	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.78179903
31	P300_19829295_ChIP-Seq_ESCs_Human	1.72311573
32	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.71067815
33	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.70472101
34	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.69481777
35	REST_21632747_ChIP-Seq_MESCs_Mouse	1.67149164
36	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.66936395
37	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.65155772
38	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.57864100
39	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.55031757
40	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.54799155
41	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.54777122
42	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.53328987
43	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.51857447
44	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.49849553
45	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.48906685
46	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.47448088
47	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.46995893
48	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.46977120
49	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.46492268
50	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.41604263
51	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.41593040
52	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.39915588
53	SMAD4_21799915_ChIP-Seq_A2780_Human	1.38298348
54	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.37742936
55	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.35583610
56	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.35282241
57	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.35022048
58	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.34336663
59	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.34152184
60	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.33232448
61	CBP_20019798_ChIP-Seq_JUKART_Human	1.31097895
62	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.31097895
63	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.29463888
64	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.29463888
65	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.29416612
66	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.28933276
67	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.28085468
68	ER_23166858_ChIP-Seq_MCF-7_Human	1.25794872
69	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.24709038
70	MYC_18940864_ChIP-ChIP_HL60_Human	1.22604776
71	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.21587461
72	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.21586107
73	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.18440380
74	RUNX2_22187159_ChIP-Seq_PCA_Human	1.16327218
75	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.15477145
76	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.15134125
77	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.14905772
78	STAT3_23295773_ChIP-Seq_U87_Human	1.13717935
79	FUS_26573619_Chip-Seq_HEK293_Human	1.13679482
80	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.12757243
81	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.11383259
82	AR_25329375_ChIP-Seq_VCAP_Human	1.10663934
83	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.10539442
84	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.09717053
85	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.07193614
86	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.05648594
87	DROSHA_22980978_ChIP-Seq_HELA_Human	1.05116225
88	TCF4_23295773_ChIP-Seq_U87_Human	1.04345228
89	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.04271070
90	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.02666748
91	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.02490200
92	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.01069609
93	IRF1_19129219_ChIP-ChIP_H3396_Human	1.00308461
94	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.99202309
95	BCAT_22108803_ChIP-Seq_LS180_Human	0.99186547
96	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.97316916
97	KDM2B_26808549_Chip-Seq_REH_Human	0.97055829
98	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.96937858
99	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.96755147
100	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.96471234

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003283_abnormal_digestive_organ	3.17233403
2	MP0001529_abnormal_vocalization	3.03207255
3	MP0002102_abnormal_ear_morphology	2.74737771
4	MP0008995_early_reproductive_senescence	2.69671970
5	MP0003315_abnormal_perineum_morphology	2.52472183
6	MP0001984_abnormal_olfaction	2.45250797
7	MP0002736_abnormal_nociception_after	2.40636226
8	MP0000778_abnormal_nervous_system	2.28430934
9	MP0001919_abnormal_reproductive_system	2.18895437
10	MP0008877_abnormal_DNA_methylation	2.17779409
11	MP0001968_abnormal_touch/_nociception	2.15445638
12	MP0009384_cardiac_valve_regurgitation	2.09974456
13	MP0005394_taste/olfaction_phenotype	2.08834500
14	MP0005499_abnormal_olfactory_system	2.08834500
15	MP0003122_maternal_imprinting	2.04385265
16	MP0002822_catalepsy	2.00674010
17	MP0004270_analgesia	1.98325379
18	MP0003942_abnormal_urinary_system	1.96690697
19	MP0003121_genomic_imprinting	1.95977741
20	MP0003567_abnormal_fetal_cardiomyocyte	1.91719009
21	MP0006276_abnormal_autonomic_nervous	1.91491234
22	MP0010386_abnormal_urinary_bladder	1.87583658
23	MP0004133_heterotaxia	1.76231578
24	MP0003880_abnormal_central_pattern	1.73708687
25	MP0003123_paternal_imprinting	1.70822413
26	MP0003787_abnormal_imprinting	1.69876328
27	MP0005389_reproductive_system_phenotype	1.65030921
28	MP0005551_abnormal_eye_electrophysiolog	1.64304093
29	MP0000566_synostosis	1.62300006
30	MP0003119_abnormal_digestive_system	1.57860652
31	MP0002735_abnormal_chemical_nociception	1.55780331
32	MP0003011_delayed_dark_adaptation	1.54595720
33	MP0003635_abnormal_synaptic_transmissio	1.54396952
34	MP0008789_abnormal_olfactory_epithelium	1.53710572
35	MP0000639_abnormal_adrenal_gland	1.52547241
36	MP0002751_abnormal_autonomic_nervous	1.49555729
37	MP0001661_extended_life_span	1.46182907
38	MP0005310_abnormal_salivary_gland	1.45429781
39	MP0002572_abnormal_emotion/affect_behav	1.44051700
40	MP0000049_abnormal_middle_ear	1.40308096
41	MP0002638_abnormal_pupillary_reflex	1.39266695
42	MP0004859_abnormal_synaptic_plasticity	1.37099524
43	MP0002063_abnormal_learning/memory/cond	1.33993422
44	MP0002733_abnormal_thermal_nociception	1.33573256
45	MP0003890_abnormal_embryonic-extraembry	1.33197613
46	MP0002272_abnormal_nervous_system	1.31865387
47	MP0002734_abnormal_mechanical_nocicepti	1.30745097
48	MP0000678_abnormal_parathyroid_gland	1.28328970
49	MP0001905_abnormal_dopamine_level	1.27805677
50	MP0003943_abnormal_hepatobiliary_system	1.27210813
51	MP0003937_abnormal_limbs/digits/tail_de	1.26160185
52	MP0002234_abnormal_pharynx_morphology	1.26081382
53	MP0004924_abnormal_behavior	1.25357387
54	MP0005386_behavior/neurological_phenoty	1.25357387
55	MP0009745_abnormal_behavioral_response	1.24232419
56	MP0000537_abnormal_urethra_morphology	1.23542763
57	MP0001486_abnormal_startle_reflex	1.23303580
58	MP0005187_abnormal_penis_morphology	1.19584652
59	MP0002282_abnormal_trachea_morphology	1.17218641
60	MP0004145_abnormal_muscle_electrophysio	1.17165046
61	MP0006072_abnormal_retinal_apoptosis	1.14490832
62	MP0003115_abnormal_respiratory_system	1.13258100
63	MP0005367_renal/urinary_system_phenotyp	1.12808608
64	MP0000516_abnormal_urinary_system	1.12808608
65	MP0005253_abnormal_eye_physiology	1.12746161
66	MP0001970_abnormal_pain_threshold	1.12498899
67	MP0002557_abnormal_social/conspecific_i	1.12441080
68	MP0004142_abnormal_muscle_tone	1.11077315
69	MP0005423_abnormal_somatic_nervous	1.08231925
70	MP0009046_muscle_twitch	1.07182999
71	MP0000955_abnormal_spinal_cord	1.06912110
72	MP0005410_abnormal_fertilization	1.03320668
73	MP0002882_abnormal_neuron_morphology	1.01541826
74	MP0001501_abnormal_sleep_pattern	1.00182882
75	MP0002067_abnormal_sensory_capabilities	0.99352407
76	MP0005195_abnormal_posterior_eye	0.98241920
77	MP0002184_abnormal_innervation	0.96259959
78	MP0003221_abnormal_cardiomyocyte_apopto	0.95322103
79	MP0003828_pulmonary_edema	0.95066959
80	MP0003195_calcinosis	0.94880312
81	MP0002752_abnormal_somatic_nervous	0.94444325
82	MP0003936_abnormal_reproductive_system	0.93479406
83	MP0000631_abnormal_neuroendocrine_gland	0.93115876
84	MP0002233_abnormal_nose_morphology	0.91279513
85	MP0002127_abnormal_cardiovascular_syste	0.89183148
86	MP0002064_seizures	0.88151280
87	MP0003698_abnormal_male_reproductive	0.87652556
88	MP0000569_abnormal_digit_pigmentation	0.87376510
89	MP0003938_abnormal_ear_development	0.86051417
90	MP0001324_abnormal_eye_pigmentation	0.85571424
91	MP0002160_abnormal_reproductive_system	0.84280189
92	MP0003861_abnormal_nervous_system	0.83623411
93	MP0001502_abnormal_circadian_rhythm	0.80564764
94	MP0000026_abnormal_inner_ear	0.80452529
95	MP0002229_neurodegeneration	0.80436483
96	MP0003385_abnormal_body_wall	0.79839531
97	MP0005391_vision/eye_phenotype	0.79579209
98	MP0000462_abnormal_digestive_system	0.79409626
99	MP0004019_abnormal_vitamin_homeostasis	0.77101704
100	MP0002210_abnormal_sex_determination	0.76037466

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Gonadal dysgenesis (HP:0000133)	7.74765637
2	Testicular neoplasm (HP:0010788)	6.07739934
3	Hypoplastic left heart (HP:0004383)	5.89678989
4	Anomalous pulmonary venous return (HP:0010772)	5.44989946
5	True hermaphroditism (HP:0010459)	5.20500421
6	Mesangial abnormality (HP:0001966)	4.79073008
7	Abnormality of the pulmonary veins (HP:0011718)	4.71826038
8	Hypoplastic heart (HP:0001961)	4.65164905
9	Degeneration of the lateral corticospinal tracts (HP:0002314)	4.52534385
10	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	4.52534385
11	Transposition of the great arteries (HP:0001669)	4.07027587
12	Abnormal connection of the cardiac segments (HP:0011545)	4.07027587
13	Abnormal ventriculo-arterial connection (HP:0011563)	4.07027587
14	Male pseudohermaphroditism (HP:0000037)	3.99564043
15	Germ cell neoplasia (HP:0100728)	3.83336679
16	Abnormality of the corticospinal tract (HP:0002492)	3.62850585
17	Shoulder girdle muscle weakness (HP:0003547)	3.61113577
18	Osteomalacia (HP:0002749)	3.56816739
19	Limb dystonia (HP:0002451)	3.41361319
20	Abnormal sex determination (HP:0012244)	3.30441382
21	Sex reversal (HP:0012245)	3.30441382
22	Female pseudohermaphroditism (HP:0010458)	3.29753969
23	Agitation (HP:0000713)	3.25455739
24	Gait imbalance (HP:0002141)	3.22835577
25	Primary adrenal insufficiency (HP:0008207)	3.08193097
26	Amyotrophic lateral sclerosis (HP:0007354)	3.08037508
27	Congenital primary aphakia (HP:0007707)	2.97274775
28	Medial flaring of the eyebrow (HP:0010747)	2.93650778
29	Nephrogenic diabetes insipidus (HP:0009806)	2.84085540
30	Abnormality of midbrain morphology (HP:0002418)	2.80544077
31	Molar tooth sign on MRI (HP:0002419)	2.80544077
32	Polyphagia (HP:0002591)	2.74353360
33	Impaired vibration sensation in the lower limbs (HP:0002166)	2.70367706
34	Vaginal atresia (HP:0000148)	2.66510455
35	Hypoplasia of the uterus (HP:0000013)	2.65929483
36	Abnormality of the lower motor neuron (HP:0002366)	2.65445593
37	Vitreoretinal degeneration (HP:0000655)	2.65319016
38	Genital tract atresia (HP:0001827)	2.64640222
39	Abnormal lung lobation (HP:0002101)	2.63960289
40	Nephronophthisis (HP:0000090)	2.60088784
41	Pendular nystagmus (HP:0012043)	2.53225937
42	Focal segmental glomerulosclerosis (HP:0000097)	2.49151133
43	Rimmed vacuoles (HP:0003805)	2.47834278
44	Brushfield spots (HP:0001088)	2.38350198
45	Morphological abnormality of the pyramidal tract (HP:0002062)	2.35290633
46	Glomerulosclerosis (HP:0000096)	2.27961151
47	Urinary bladder sphincter dysfunction (HP:0002839)	2.26712194
48	Atrophy/Degeneration involving motor neurons (HP:0007373)	2.24564499
49	Urinary urgency (HP:0000012)	2.19167999
50	Primary amenorrhea (HP:0000786)	2.17709413
51	Hyperventilation (HP:0002883)	2.14154302
52	Volvulus (HP:0002580)	2.12354971
53	Abnormality of the renal medulla (HP:0100957)	2.11696457
54	Aplasia/hypoplasia of the uterus (HP:0008684)	2.10732724
55	Periauricular skin pits (HP:0100277)	2.10502858
56	Preauricular pit (HP:0004467)	2.10502858
57	Chronic hepatic failure (HP:0100626)	2.07500230
58	Gonadotropin excess (HP:0000837)	2.05305636
59	Male infertility (HP:0003251)	2.04320978
60	Specific learning disability (HP:0001328)	2.02934630
61	Progressive cerebellar ataxia (HP:0002073)	2.00282368
62	Renal cortical cysts (HP:0000803)	1.97944808
63	Genetic anticipation (HP:0003743)	1.93090721
64	Lissencephaly (HP:0001339)	1.91135387
65	Broad foot (HP:0001769)	1.90057337
66	Tachypnea (HP:0002789)	1.89741002
67	Congenital diaphragmatic hernia (HP:0000776)	1.89526163
68	Stage 5 chronic kidney disease (HP:0003774)	1.89173748
69	Decreased testicular size (HP:0008734)	1.88474722
70	Keratoconus (HP:0000563)	1.86888451
71	Increased corneal curvature (HP:0100692)	1.86888451
72	Restlessness (HP:0000711)	1.86275349
73	Pancreatic fibrosis (HP:0100732)	1.85933881
74	Poor coordination (HP:0002370)	1.84785461
75	Irregular epiphyses (HP:0010582)	1.83263298
76	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.78841704
77	Abnormality of the peritoneum (HP:0002585)	1.77225491
78	Poor suck (HP:0002033)	1.77156607
79	Abolished electroretinogram (ERG) (HP:0000550)	1.76627334
80	Progressive inability to walk (HP:0002505)	1.75784474
81	Aplasia/Hypoplasia of the lens (HP:0008063)	1.74871722
82	Preaxial foot polydactyly (HP:0001841)	1.74050215
83	Retinal dysplasia (HP:0007973)	1.73281287
84	Myokymia (HP:0002411)	1.71798125
85	Short tibia (HP:0005736)	1.71141689
86	Arthropathy (HP:0003040)	1.71126678
87	Tented upper lip vermilion (HP:0010804)	1.70164434
88	Narrow forehead (HP:0000341)	1.66805928
89	Pancreatic cysts (HP:0001737)	1.66411311
90	Abnormality of the vocal cords (HP:0008777)	1.64244336
91	Spastic gait (HP:0002064)	1.61689625
92	Nephroblastoma (Wilms tumor) (HP:0002667)	1.60463902
93	Paraplegia (HP:0010550)	1.60432782
94	Micropenis (HP:0000054)	1.60059568
95	Tubulointerstitial fibrosis (HP:0005576)	1.59605522
96	Abnormality of the pubic bones (HP:0003172)	1.59088454
97	Ovarian neoplasm (HP:0100615)	1.58468369
98	Embryonal renal neoplasm (HP:0011794)	1.58126834
99	Lower limb muscle weakness (HP:0007340)	1.58043869
100	Abnormal biliary tract physiology (HP:0012439)	1.56896789

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TNIK	6.59721292
2	MARK1	5.22979222
3	NLK	3.76108528
4	ADRBK2	2.76358332
5	MAP3K4	2.67061159
6	CASK	2.28890281
7	DYRK2	2.23563669
8	NTRK2	2.18008490
9	MAP2K7	2.11029017
10	CSNK1G1	2.04851522
11	BCR	1.96555821
12	MAPK13	1.96053986
13	CSNK1A1L	1.93679782
14	CAMKK2	1.87311383
15	CSNK1G3	1.86790613
16	CSNK1G2	1.85821046
17	TRIM28	1.74105709
18	WNK3	1.69539632
19	FRK	1.68931707
20	PINK1	1.64188119
21	MAP2K4	1.57974130
22	BMPR1B	1.56936170
23	EPHB1	1.44829193
24	CDK19	1.43279737
25	INSRR	1.33270045
26	SGK223	1.32717771
27	SGK494	1.32717771
28	BRSK2	1.31786664
29	EPHA3	1.30290277
30	SGK2	1.27642208
31	MAPKAPK5	1.25015354
32	BCKDK	1.21939595
33	OXSR1	1.21477556
34	PAK3	1.20971204
35	EPHB2	1.10870334
36	YES1	1.03921765
37	ERBB3	1.03752808
38	MAP3K12	1.03698638
39	DYRK1A	1.03610513
40	PLK2	0.97870118
41	MAP4K2	0.97305546
42	PRKD3	0.89601746
43	MINK1	0.87981414
44	RPS6KA2	0.86138786
45	CAMK2B	0.85777385
46	DYRK1B	0.84643132
47	CDK5	0.81372922
48	NTRK3	0.75889708
49	MAP3K6	0.74697687
50	GRK1	0.74497127
51	DYRK3	0.73701714
52	BRD4	0.71608067
53	STK39	0.70852732
54	NUAK1	0.65771141
55	PNCK	0.63521360
56	CAMK2A	0.62402995
57	DAPK2	0.60318383
58	PRKCE	0.59807922
59	NTRK1	0.59738751
60	CDK4	0.57592047
61	MKNK1	0.57167690
62	PRKD2	0.56025021
63	PRKACA	0.53132356
64	UHMK1	0.51998304
65	RPS6KA5	0.51044661
66	SIK2	0.50969200
67	BMPR2	0.50352676
68	PRKCG	0.49135502
69	GRK5	0.48058377
70	PLK4	0.47085334
71	RPS6KA6	0.46101890
72	EPHA4	0.46000347
73	TIE1	0.45877809
74	BRSK1	0.45365860
75	SGK3	0.45217540
76	WNK4	0.44502663
77	MUSK	0.42873653
78	RPS6KA4	0.42320967
79	GSK3A	0.39525556
80	MKNK2	0.39191203
81	EIF2AK3	0.38767940
82	TNK2	0.37663795
83	CAMK2D	0.36949801
84	CAMKK1	0.36012565
85	CDK14	0.35526740
86	STK11	0.35463245
87	CAMK4	0.33273812
88	CSNK1D	0.33070510
89	ADRBK1	0.32967895
90	RPS6KC1	0.32634676
91	RPS6KL1	0.32634676
92	CDK18	0.31933837
93	MAP2K6	0.31134124
94	STK16	0.30368907
95	WEE1	0.30305935
96	LIMK1	0.29664182
97	SGK1	0.29659310
98	CDK15	0.29137658
99	MAPK4	0.27880283
100	ERBB2	0.27828966

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	3.32370865
2	Nicotine addiction_Homo sapiens_hsa05033	2.90691119
3	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.80057199
4	Cocaine addiction_Homo sapiens_hsa05030	2.43684281
5	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.32368037
6	Steroid biosynthesis_Homo sapiens_hsa00100	2.30712896
7	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.23661907
8	Hedgehog signaling pathway_Homo sapiens_hsa04340	2.19782285
9	Basal cell carcinoma_Homo sapiens_hsa05217	2.15480438
10	Axon guidance_Homo sapiens_hsa04360	2.02917428
11	Phototransduction_Homo sapiens_hsa04744	1.93130264
12	Sulfur relay system_Homo sapiens_hsa04122	1.85620456
13	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.84111047
14	Dopaminergic synapse_Homo sapiens_hsa04728	1.82177120
15	Butanoate metabolism_Homo sapiens_hsa00650	1.81202884
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.73280568
17	GABAergic synapse_Homo sapiens_hsa04727	1.69729486
18	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.65023849
19	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.61323237
20	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.57517561
21	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.53700040
22	Morphine addiction_Homo sapiens_hsa05032	1.53497527
23	Amphetamine addiction_Homo sapiens_hsa05031	1.45244489
24	Glutamatergic synapse_Homo sapiens_hsa04724	1.42571018
25	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.39991280
26	Protein export_Homo sapiens_hsa03060	1.38034910
27	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.32272478
28	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.31489383
29	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.31184076
30	Insulin secretion_Homo sapiens_hsa04911	1.26102089
31	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.25886435
32	Serotonergic synapse_Homo sapiens_hsa04726	1.24579068
33	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.24240382
34	Fatty acid elongation_Homo sapiens_hsa00062	1.22509868
35	Linoleic acid metabolism_Homo sapiens_hsa00591	1.20748755
36	Circadian entrainment_Homo sapiens_hsa04713	1.17393562
37	Taste transduction_Homo sapiens_hsa04742	1.16940547
38	Peroxisome_Homo sapiens_hsa04146	1.13462851
39	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.12128199
40	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.10674758
41	Folate biosynthesis_Homo sapiens_hsa00790	1.10369835
42	Hippo signaling pathway_Homo sapiens_hsa04390	1.07425748
43	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.05260454
44	Propanoate metabolism_Homo sapiens_hsa00640	1.05080578
45	Chemical carcinogenesis_Homo sapiens_hsa05204	1.02724696
46	Cholinergic synapse_Homo sapiens_hsa04725	1.00895792
47	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.98082787
48	Olfactory transduction_Homo sapiens_hsa04740	0.96668933
49	Ether lipid metabolism_Homo sapiens_hsa00565	0.96135416
50	Regulation of autophagy_Homo sapiens_hsa04140	0.93885444
51	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.93313916
52	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.93255121
53	Melanogenesis_Homo sapiens_hsa04916	0.92601721
54	Wnt signaling pathway_Homo sapiens_hsa04310	0.87398639
55	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.86791761
56	Basal transcription factors_Homo sapiens_hsa03022	0.84848716
57	Gastric acid secretion_Homo sapiens_hsa04971	0.84466456
58	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.83586126
59	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.82447672
60	Parkinsons disease_Homo sapiens_hsa05012	0.81645104
61	Tyrosine metabolism_Homo sapiens_hsa00350	0.78669744
62	ABC transporters_Homo sapiens_hsa02010	0.78298297
63	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.77024957
64	Sulfur metabolism_Homo sapiens_hsa00920	0.76784581
65	Nitrogen metabolism_Homo sapiens_hsa00910	0.75762871
66	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.75678675
67	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.73791003
68	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.70977841
69	Retinol metabolism_Homo sapiens_hsa00830	0.70753185
70	Salivary secretion_Homo sapiens_hsa04970	0.68144892
71	AMPK signaling pathway_Homo sapiens_hsa04152	0.67904721
72	Long-term depression_Homo sapiens_hsa04730	0.67780063
73	Alcoholism_Homo sapiens_hsa05034	0.67336410
74	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.66735617
75	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.66287695
76	Galactose metabolism_Homo sapiens_hsa00052	0.63629898
77	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.55707763
78	Circadian rhythm_Homo sapiens_hsa04710	0.53484367
79	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.52937710
80	Calcium signaling pathway_Homo sapiens_hsa04020	0.48722381
81	cAMP signaling pathway_Homo sapiens_hsa04024	0.47583609
82	Oxidative phosphorylation_Homo sapiens_hsa00190	0.46092030
83	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.45958618
84	Ras signaling pathway_Homo sapiens_hsa04014	0.45429900
85	Glutathione metabolism_Homo sapiens_hsa00480	0.43515589
86	Metabolic pathways_Homo sapiens_hsa01100	0.43383224
87	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.42693985
88	Alzheimers disease_Homo sapiens_hsa05010	0.42271990
89	Cardiac muscle contraction_Homo sapiens_hsa04260	0.42175296
90	Tryptophan metabolism_Homo sapiens_hsa00380	0.40103477
91	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.37241331
92	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.36572365
93	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.36562335
94	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.35793544
95	Huntingtons disease_Homo sapiens_hsa05016	0.35420558
96	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.34692061
97	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.34016315
98	Gap junction_Homo sapiens_hsa04540	0.32608180
99	Renin secretion_Homo sapiens_hsa04924	0.32229381
100	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.31923732

CES5AP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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