CETN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene plays important roles in the determination of centrosome position and segregation, and in the process of microtubule severing. This protein is localized to the centrosome of interphase cells, and redistributes to the region of the spindle poles during mitosis, reflecting the dynamic behavior of the centrosome during the cell cycle. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.98181983
2piRNA metabolic process (GO:0034587)9.96618857
3reproduction (GO:0000003)9.38193252
4motile cilium assembly (GO:0044458)9.25036255
5spermatid development (GO:0007286)9.15812630
6male meiosis (GO:0007140)8.89491233
7epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.58013353
8cilium movement (GO:0003341)8.46772534
9synaptonemal complex organization (GO:0070193)8.31599937
10synaptonemal complex assembly (GO:0007130)8.10764883
11single fertilization (GO:0007338)7.52001467
12regulation of cilium movement (GO:0003352)7.29532714
13fertilization (GO:0009566)6.49020326
14DNA methylation involved in gamete generation (GO:0043046)6.47597464
15sperm capacitation (GO:0048240)6.46819082
16spermatogenesis (GO:0007283)6.13043008
17male gamete generation (GO:0048232)6.10903476
18negative regulation of inclusion body assembly (GO:0090084)5.96498759
19chromosome organization involved in meiosis (GO:0070192)5.72260471
20male meiosis I (GO:0007141)5.70576928
21gamete generation (GO:0007276)5.61419149
22microtubule depolymerization (GO:0007019)5.51783783
23cellular process involved in reproduction in multicellular organism (GO:0022412)5.35051673
24germ cell development (GO:0007281)5.29193793
25ventricular system development (GO:0021591)5.24995390
26organic cation transport (GO:0015695)5.16328119
27seminiferous tubule development (GO:0072520)5.14107473
28meiotic nuclear division (GO:0007126)5.10981766
29cell recognition (GO:0008037)4.93658818
30regulation of inclusion body assembly (GO:0090083)4.91565078
31calcium ion-dependent exocytosis (GO:0017156)4.81831029
32meiosis I (GO:0007127)4.60925332
33microtubule severing (GO:0051013)4.49785103
34monoubiquitinated protein deubiquitination (GO:0035520)4.43114337
35multicellular organismal reproductive process (GO:0048609)4.39869103
36regulation of microtubule-based movement (GO:0060632)4.31724478
37meiotic cell cycle (GO:0051321)4.26043485
38protein localization to cilium (GO:0061512)4.22577846
39genitalia morphogenesis (GO:0035112)4.13896972
40spermatid nucleus differentiation (GO:0007289)4.06223337
41glycerol ether metabolic process (GO:0006662)4.04415403
42chaperone-mediated protein complex assembly (GO:0051131)3.95124077
43left/right pattern formation (GO:0060972)3.92535367
44ether metabolic process (GO:0018904)3.73315487
45lactate metabolic process (GO:0006089)3.65076680
46gene silencing by RNA (GO:0031047)3.65045779
47intraciliary transport (GO:0042073)3.62049907
48multicellular organismal development (GO:0007275)3.59787348
49sequestering of actin monomers (GO:0042989)3.53679185
50synapsis (GO:0007129)3.49511282
51protein K11-linked deubiquitination (GO:0035871)3.45335972
52chromosome condensation (GO:0030261)3.44322010
53alditol metabolic process (GO:0019400)3.38932713
54protein polyglutamylation (GO:0018095)3.34574126
55GTP biosynthetic process (GO:0006183)3.34264287
56DNA packaging (GO:0006323)3.31957182
57meiotic cell cycle process (GO:1903046)3.30041440
58axoneme assembly (GO:0035082)3.29703798
59negative regulation of organelle assembly (GO:1902116)3.28078311
60polyol catabolic process (GO:0046174)3.27634974
61nucleoside diphosphate phosphorylation (GO:0006165)3.26270560
62microtubule-based movement (GO:0007018)3.19984002
63amino-acid betaine transport (GO:0015838)3.15385020
64carnitine transport (GO:0015879)3.15385020
65carnitine transmembrane transport (GO:1902603)3.12403915
66regulation of centriole replication (GO:0046599)3.04994085
67regulation of protein polyubiquitination (GO:1902914)3.04362975
68glycerol metabolic process (GO:0006071)3.03547123
69regulation of spindle checkpoint (GO:0090231)3.02744657
70cilium organization (GO:0044782)3.00691978
71UTP biosynthetic process (GO:0006228)2.98941530
72cilium morphogenesis (GO:0060271)2.92205546
73mitotic sister chromatid cohesion (GO:0007064)2.91730139
74cellular component assembly involved in morphogenesis (GO:0010927)2.90014753
75cilium assembly (GO:0042384)2.84999111
76glycolytic process (GO:0006096)2.84831226
77protein refolding (GO:0042026)2.83556956
78regulation of meiosis I (GO:0060631)2.82723729
79microtubule polymerization or depolymerization (GO:0031109)2.82460120
80single strand break repair (GO:0000012)2.81686221
81nuclear pore complex assembly (GO:0051292)2.78752118
82centriole assembly (GO:0098534)2.76267142
83UTP metabolic process (GO:0046051)2.72440826
84centriole replication (GO:0007099)2.67773985
85gene silencing (GO:0016458)2.65074669
86negative regulation of DNA repair (GO:0045738)2.64224131
87nucleus organization (GO:0006997)2.61060435
88fusion of sperm to egg plasma membrane (GO:0007342)14.3102068
89cilium or flagellum-dependent cell motility (GO:0001539)13.0919966
90acrosome assembly (GO:0001675)12.6422595
91sperm motility (GO:0030317)12.4512621
92sperm-egg recognition (GO:0035036)11.4211355
93multicellular organism reproduction (GO:0032504)11.3227362
94cell wall macromolecule metabolic process (GO:0044036)11.2560530
95cell wall macromolecule catabolic process (GO:0016998)11.2560530
96plasma membrane fusion (GO:0045026)10.9040640
97binding of sperm to zona pellucida (GO:0007339)10.6546772
98axonemal dynein complex assembly (GO:0070286)10.5536812
99acrosome reaction (GO:0007340)10.3667069
100cell-cell recognition (GO:0009988)10.2238963

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.20426198
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.82273707
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.67468630
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.73781780
5FLI1_27457419_Chip-Seq_LIVER_Mouse2.64780206
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.63468827
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.59318895
8ZNF274_21170338_ChIP-Seq_K562_Hela2.38577491
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.22220341
10PCGF2_27294783_Chip-Seq_ESCs_Mouse2.19424629
11EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.11656648
12CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.04323926
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.1942448
14STAT6_21828071_ChIP-Seq_BEAS2B_Human1.88284320
15KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.82291029
16RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.76738916
17GATA1_26923725_Chip-Seq_HPCs_Mouse1.76457650
18ELK4_26923725_Chip-Seq_MESODERM_Mouse1.73834904
19TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.69183106
20PCGF2_27294783_Chip-Seq_NPCs_Mouse1.68261428
21CBX2_27304074_Chip-Seq_ESCs_Mouse1.66271765
22VDR_22108803_ChIP-Seq_LS180_Human1.63034754
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.61576786
24STAT1_17558387_ChIP-Seq_HELA_Human1.61000711
25KAP1_22055183_ChIP-Seq_ESCs_Mouse1.54324780
26GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.54142109
27NFE2_27457419_Chip-Seq_LIVER_Mouse1.50675330
28WDR5_24793694_ChIP-Seq_LNCAP_Human1.49188981
29ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.47410340
30TAL1_26923725_Chip-Seq_HPCs_Mouse1.47337356
31SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44134834
32KDM2B_26808549_Chip-Seq_REH_Human1.43786432
33FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41981892
34SOX2_22085726_ChIP-Seq_NPCs_Mouse1.36139961
35GATA3_21867929_ChIP-Seq_CD8_Mouse1.34036797
36MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.33395033
37TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33394983
38CBP_20019798_ChIP-Seq_JUKART_Human1.31292911
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31292911
40FLI1_21867929_ChIP-Seq_TH2_Mouse1.24531944
41REST_21632747_ChIP-Seq_MESCs_Mouse1.20453323
42CRX_20693478_ChIP-Seq_RETINA_Mouse1.19833556
43LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.19820448
44NANOG_18555785_Chip-Seq_ESCs_Mouse1.18706523
45GATA3_21867929_ChIP-Seq_TH1_Mouse1.17849282
46RNF2_27304074_Chip-Seq_NSC_Mouse1.17145274
47EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16612600
48P53_21459846_ChIP-Seq_SAOS-2_Human1.13925672
49ZFP57_27257070_Chip-Seq_ESCs_Mouse1.13111962
50SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.11193732
51CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10815350
52OCT4_18555785_Chip-Seq_ESCs_Mouse1.10199655
53CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09378124
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08643272
55P53_22387025_ChIP-Seq_ESCs_Mouse1.07936158
56* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07832857
57* SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.06479403
58POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06459487
59TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06459487
60EZH2_27294783_Chip-Seq_NPCs_Mouse1.06087685
61PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.05837643
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05446728
63GF1_26923725_Chip-Seq_HPCs_Mouse1.05182356
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05083333
65PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03490785
66P300_18555785_Chip-Seq_ESCs_Mouse1.02703469
67FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02180819
68RAD21_21589869_ChIP-Seq_MESCs_Mouse1.02052756
69TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00885253
70EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99023687
71CMYC_18555785_Chip-Seq_ESCs_Mouse0.98906380
72OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98781385
73EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.98551061
74KLF4_18555785_Chip-Seq_ESCs_Mouse0.98535145
75PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96246121
76RUNX1_26923725_Chip-Seq_HPCs_Mouse0.96041241
77ERG_20517297_ChIP-Seq_VCAP_Human0.93997254
78PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93791071
79ESRRB_18555785_Chip-Seq_ESCs_Mouse0.93694081
80STAT3_18555785_Chip-Seq_ESCs_Mouse0.93105168
81PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92352503
82TAF15_26573619_Chip-Seq_HEK293_Human0.91971667
83SUZ12_18555785_Chip-Seq_ESCs_Mouse0.91627589
84SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90430497
85CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.89497076
86* ESET_19884257_ChIP-Seq_ESCs_Mouse0.88668649
87SOX9_26525672_Chip-Seq_HEART_Mouse0.87699512
88PU1_27457419_Chip-Seq_LIVER_Mouse0.87136460
89SPI1_26923725_Chip-Seq_HPCs_Mouse0.86516690
90LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.86273629
91RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85835740
92CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84761168
93RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.84555523
94RUNX1_27457419_Chip-Seq_LIVER_Mouse0.84136230
95FLI1_21867929_ChIP-Seq_CD8_Mouse0.83673440
96EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.83443878
97GF1B_26923725_Chip-Seq_HPCs_Mouse0.83381022
98YY1_22570637_ChIP-Seq_MALME-3M_Human0.83062692
99SOX2_18555785_Chip-Seq_ESCs_Mouse0.82229012
100MYC_27129775_Chip-Seq_CORNEA_Mouse0.82034203

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.06881540
2MP0001929_abnormal_gametogenesis5.67191896
3MP0008877_abnormal_DNA_methylation5.38455598
4MP0002210_abnormal_sex_determination3.83536320
5MP0002161_abnormal_fertility/fecundity3.26450682
6MP0001145_abnormal_male_reproductive3.23015804
7MP0000653_abnormal_sex_gland2.80512018
8MP0002653_abnormal_ependyma_morphology2.67619405
9MP0002160_abnormal_reproductive_system2.04201218
10MP0005410_abnormal_fertilization15.5960502
11MP0008057_abnormal_DNA_replication1.97206334
12MP0005670_abnormal_white_adipose1.86090066
13MP0005623_abnormal_meninges_morphology1.79366411
14MP0005647_abnormal_sex_gland1.33148471
15MP0008058_abnormal_DNA_repair1.31661832
16MP0002282_abnormal_trachea_morphology1.24913733
17MP0003646_muscle_fatigue1.23290080
18MP0010094_abnormal_chromosome_stability1.10855695
19MP0003011_delayed_dark_adaptation1.06636249
20MP0005389_reproductive_system_phenotype1.04916343
21MP0004233_abnormal_muscle_weight1.04384230
22MP0008995_early_reproductive_senescence1.02815628
23MP0001765_abnormal_ion_homeostasis1.02751916
24MP0009046_muscle_twitch1.02045632
25MP0001984_abnormal_olfaction0.98155291
26MP0008007_abnormal_cellular_replicative0.91590979
27MP0003786_premature_aging0.90906786
28MP0000569_abnormal_digit_pigmentation0.71029771
29MP0004134_abnormal_chest_morphology0.66782737
30MP0002234_abnormal_pharynx_morphology0.66303666
31MP0003950_abnormal_plasma_membrane0.59872468
32MP0001545_abnormal_hematopoietic_system0.59042223
33MP0005397_hematopoietic_system_phenotyp0.59042223
34MP0000358_abnormal_cell_content/0.56823256
35MP0004808_abnormal_hematopoietic_stem0.53472716
36MP0005636_abnormal_mineral_homeostasis0.53243748
37MP0010307_abnormal_tumor_latency0.52522783
38MP0003699_abnormal_female_reproductive0.48875248
39MP0004019_abnormal_vitamin_homeostasis0.48278717
40MP0002928_abnormal_bile_duct0.47148170
41MP0003878_abnormal_ear_physiology0.47074104
42MP0005377_hearing/vestibular/ear_phenot0.47074104
43MP0003115_abnormal_respiratory_system0.46751624
44MP0004036_abnormal_muscle_relaxation0.45966921
45MP0003329_amyloid_beta_deposits0.44734081
46MP0003111_abnormal_nucleus_morphology0.44360164
47MP0005551_abnormal_eye_electrophysiolog0.43980998
48MP0005253_abnormal_eye_physiology0.43955975
49MP0009278_abnormal_bone_marrow0.42176738
50MP0001324_abnormal_eye_pigmentation0.42074743
51MP0001119_abnormal_female_reproductive0.41225869
52MP0005666_abnormal_adipose_tissue0.41172614
53MP0006036_abnormal_mitochondrial_physio0.37328773
54MP0001730_embryonic_growth_arrest0.37214963
55MP0001727_abnormal_embryo_implantation0.35059784
56MP0001293_anophthalmia0.34628028
57MP0005391_vision/eye_phenotype0.34176289
58MP0002139_abnormal_hepatobiliary_system0.33069727
59MP0002269_muscular_atrophy0.30773944
60MP0001764_abnormal_homeostasis0.30766809
61MP0006072_abnormal_retinal_apoptosis0.29011177
62MP0003077_abnormal_cell_cycle0.28835358
63MP0002971_abnormal_brown_adipose0.28271355
64MP0000427_abnormal_hair_cycle0.26937748
65MP0003633_abnormal_nervous_system0.26223557
66MP0000313_abnormal_cell_death0.26109347
67MP0002102_abnormal_ear_morphology0.25781414
68MP0009115_abnormal_fat_cell0.25478915
69MP0004133_heterotaxia0.24562997
70MP0003861_abnormal_nervous_system0.23225398
71MP0004811_abnormal_neuron_physiology0.23208202
72MP0000604_amyloidosis0.21737555
73MP0002152_abnormal_brain_morphology0.21642582
74MP0003631_nervous_system_phenotype0.20237493
75MP0001661_extended_life_span0.19397881
76MP0002084_abnormal_developmental_patter0.19032138
77MP0002736_abnormal_nociception_after0.18996341
78MP0008961_abnormal_basal_metabolism0.18710816
79MP0003879_abnormal_hair_cell0.18550525
80MP0001851_eye_inflammation0.18320321
81MP0002092_abnormal_eye_morphology0.18227706
82MP0000751_myopathy0.17415071
83MP0006035_abnormal_mitochondrial_morpho0.16292291
84MP0002169_no_abnormal_phenotype0.16287794
85MP0002873_normal_phenotype0.16048345
86MP0003045_fibrosis0.15487172
87MP0000647_abnormal_sebaceous_gland0.14220124
88MP0005365_abnormal_bile_salt0.13625657
89MP0002229_neurodegeneration0.13576124
90MP0004043_abnormal_pH_regulation0.12725070
91MP0005195_abnormal_posterior_eye0.12663050
92MP0000534_abnormal_ureter_morphology0.12449798
93MP0003948_abnormal_gas_homeostasis0.12395935
94MP0000001_mammalian_phenotype0.11886778
95MP0001849_ear_inflammation0.11859336
96MP0005380_embryogenesis_phenotype0.11786243
97MP0001672_abnormal_embryogenesis/_devel0.11786243
98MP0006138_congestive_heart_failure0.11747431
99MP0003936_abnormal_reproductive_system0.11730700
100MP0002970_abnormal_white_adipose0.11706175

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.80156433
2Abnormal respiratory motile cilium morphology (HP:0005938)9.21611812
3Abnormal respiratory epithelium morphology (HP:0012253)9.21611812
4Abnormal ciliary motility (HP:0012262)8.03521008
5Rhinitis (HP:0012384)8.00427656
6Chronic bronchitis (HP:0004469)7.78904011
7Infertility (HP:0000789)6.36606010
8Nasal polyposis (HP:0100582)6.33528898
9Abnormality of the nasal mucosa (HP:0000433)5.20812549
10Bronchiectasis (HP:0002110)4.52169718
11Bronchitis (HP:0012387)4.45183233
12Nephronophthisis (HP:0000090)4.28098641
13Recurrent sinusitis (HP:0011108)3.72166182
14Male infertility (HP:0003251)3.28881583
15Abnormality of the lower motor neuron (HP:0002366)3.27015898
16Abnormality of the renal medulla (HP:0100957)3.26549894
17Recurrent otitis media (HP:0000403)3.26266351
18Tubulointerstitial nephritis (HP:0001970)2.89201763
19Gonadotropin excess (HP:0000837)2.89186238
20Abnormal spermatogenesis (HP:0008669)2.85497932
21Molar tooth sign on MRI (HP:0002419)2.60619888
22Abnormality of midbrain morphology (HP:0002418)2.60619888
23Medial flaring of the eyebrow (HP:0010747)2.56626059
24Amyotrophic lateral sclerosis (HP:0007354)2.54373142
25Fibular hypoplasia (HP:0003038)2.53866277
26Tubular atrophy (HP:0000092)2.45451475
27Tubulointerstitial abnormality (HP:0001969)2.38635806
28Recurrent bronchitis (HP:0002837)2.22702715
29Azoospermia (HP:0000027)2.15384903
30Postaxial foot polydactyly (HP:0001830)2.00485387
31Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.7464018
32Dynein arm defect of respiratory motile cilia (HP:0012255)13.3243567
33Absent/shortened dynein arms (HP:0200106)13.3243567
34Impaired proprioception (HP:0010831)1.96508672
35Stage 5 chronic kidney disease (HP:0003774)1.95761881
36Impulsivity (HP:0100710)1.94046850
37Hypoplasia of the capital femoral epiphysis (HP:0003090)1.92339151
38Upper motor neuron abnormality (HP:0002127)1.85861435
39Tubulointerstitial fibrosis (HP:0005576)1.85071594
40Abnormality of the dental root (HP:0006486)1.83393197
41Taurodontia (HP:0000679)1.83393197
42Abnormality of permanent molar morphology (HP:0011071)1.83393197
43Abnormality of the renal cortex (HP:0011035)1.81768565
44Absent frontal sinuses (HP:0002688)1.78306145
45Congenital hepatic fibrosis (HP:0002612)1.77290389
46Abnormality of molar (HP:0011077)1.70931611
47Abnormality of molar morphology (HP:0011070)1.70931611
48Oculomotor apraxia (HP:0000657)1.69784364
49Abnormality of dentin (HP:0010299)1.69091822
50J-shaped sella turcica (HP:0002680)1.68662937
5111 pairs of ribs (HP:0000878)1.67968423
52Abnormality of the dental pulp (HP:0006479)1.67055895
53Short ribs (HP:0000773)1.66244371
54Polydipsia (HP:0001959)1.66033603
55Abnormal drinking behavior (HP:0030082)1.66033603
56Degeneration of anterior horn cells (HP:0002398)1.65556221
57Abnormality of the anterior horn cell (HP:0006802)1.65556221
58Microglossia (HP:0000171)1.65417142
59Chronic sinusitis (HP:0011109)1.63008674
60Aplasia/Hypoplasia of the fibula (HP:0006492)1.60902684
61Renal dysplasia (HP:0000110)1.58477221
62Abnormality of renal excretion (HP:0011036)1.57646419
63Supernumerary spleens (HP:0009799)1.55582337
64Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.55557857
65Postaxial hand polydactyly (HP:0001162)1.53104738
66Facial cleft (HP:0002006)1.52827374
67Absent epiphyses (HP:0010577)1.51388520
68Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.51388520
69Breast carcinoma (HP:0003002)1.47237856
70Spastic tetraparesis (HP:0001285)1.46564252
71Congenital primary aphakia (HP:0007707)1.45651670
72Gait imbalance (HP:0002141)1.45566198
73Cholecystitis (HP:0001082)1.42131837
74Abnormal gallbladder physiology (HP:0012438)1.42131837
75Dyschromatopsia (HP:0007641)1.41764065
76Cystic liver disease (HP:0006706)1.41461176
77Aplasia/Hypoplasia of the tongue (HP:0010295)1.40408431
78Heterotopia (HP:0002282)1.36117101
79Selective tooth agenesis (HP:0001592)1.32553606
80Bell-shaped thorax (HP:0001591)1.31398838
81Broad distal phalanx of finger (HP:0009836)1.31148690
82Pancreatic fibrosis (HP:0100732)1.31115867
83Deformed sella turcica (HP:0002681)1.30624242
84Short thorax (HP:0010306)1.29911388
85Vascular calcification (HP:0004934)1.29514887
86Large eyes (HP:0001090)1.27805265
87Median cleft lip (HP:0000161)1.27650082
88Hypoplasia of dental enamel (HP:0006297)1.27061967
89Aplasia/Hypoplasia of the lens (HP:0008063)1.26954770
90Nephrogenic diabetes insipidus (HP:0009806)1.23645820
91Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.23512498
92Nephropathy (HP:0000112)1.22232671
93Decreased central vision (HP:0007663)1.20006949
94Abnormality of ocular smooth pursuit (HP:0000617)1.19321819
95Abnormal biliary tract physiology (HP:0012439)1.18062507
96Bile duct proliferation (HP:0001408)1.18062507
97Conjunctival telangiectasia (HP:0000524)1.17096296
98Cardiovascular calcification (HP:0011915)1.16131400
99True hermaphroditism (HP:0010459)1.15639183
100Abnormal urine output (HP:0012590)1.14299596

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK39.52962843
2PDK49.52962843
3PDK26.19553689
4TESK14.16245122
5PRKD33.18598943
6ICK2.84824467
7PTK2B2.27925719
8WNK42.24832391
9STK392.18870678
10PNCK2.11819339
11NEK21.79914856
12STK381.26856977
13WNK10.98322041
14PDK10.97257205
15MAPK150.89791281
16PASK0.89700071
17TYRO30.89055588
18DYRK1B0.86904311
19CCNB10.86349507
20STK30.83569639
21DYRK30.74121402
22IRAK10.72319430
23CDC70.71677815
24TTK0.64116396
25PINK10.59244005
26WEE10.54655557
27LMTK20.54117240
28TESK20.50221615
29CHEK20.47697230
30ATR0.45861330
31CHEK10.45524209
32CAMK1G0.40627985
33PDPK10.37196456
34MAP2K60.36123200
35STK38L0.34187832
36ATM0.32509813
37EEF2K0.31282419
38PLK40.31181109
39NTRK20.30650014
40MUSK0.27040092
41IRAK20.26981258
42CAMKK10.26432773
43BMPR1B0.24082128
44PLK10.23747709
45PAK10.23682785
46PRKCG0.22774935
47MTOR0.21675573
48RIPK40.19992672
49PAK20.19320412
50MAPKAPK50.19057808
51RPS6KB10.17586515
52PRKAA10.17367049
53MAP3K100.12694329
54MARK20.12633486
55CDK120.12423525
56BRAF0.10812295
57BRSK20.10191879
58NEK60.09342683
59MAP3K40.07791386
60WNK30.07730180
61PRKG10.07721339
62MARK30.06907860
63CDK150.06315166
64CSNK2A10.06180572
65CSNK1D0.05793014
66PRKCZ0.05419881
67PRKCQ0.05286161
68CDK10.04410615
69CSF1R0.04288199
70CDK180.04166697
71CDK11A0.03269975
72CDK20.02775346
73MAPK80.02754137
74PRKACB0.02609770
75PRKDC0.01996694
76GSK3B0.01894923
77CDK140.01491825
78STK100.01448354
79RPS6KA10.01320812
80PAK60.01147718
81PRKG20.01059137
82CSNK2A20.00406500
83SRC-0.0611367
84MAPK1-0.0540717
85CSK-0.0519434
86ZAP70-0.0512847
87MAP3K5-0.0484215
88INSR-0.0465160
89AURKA-0.0447725
90PDGFRB-0.0439085
91MAPK10-0.0304551
92PRKCA-0.0258454
93PAK4-0.0188697
94CAMK2A-0.0186648
95EGFR-0.0162516
96RPS6KA3-0.0084506
97PKN1-0.0077234
98STK11-0.0046281
99BRSK1-0.0043633
100PRKCB-0.0036591

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.86967727
2Pyruvate metabolism_Homo sapiens_hsa006204.61851219
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.28307657
4Propanoate metabolism_Homo sapiens_hsa006403.77971053
5Fatty acid biosynthesis_Homo sapiens_hsa000613.14735282
6Glucagon signaling pathway_Homo sapiens_hsa049223.02214825
7Basal transcription factors_Homo sapiens_hsa030222.62392295
8Pentose phosphate pathway_Homo sapiens_hsa000302.58003251
9Selenocompound metabolism_Homo sapiens_hsa004502.55847594
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.32811297
11Linoleic acid metabolism_Homo sapiens_hsa005912.24385619
12Fanconi anemia pathway_Homo sapiens_hsa034602.14419693
13Oocyte meiosis_Homo sapiens_hsa041141.99618518
14Glycosaminoglycan degradation_Homo sapiens_hsa005311.98026988
15Dorso-ventral axis formation_Homo sapiens_hsa043201.96414716
16Glycerolipid metabolism_Homo sapiens_hsa005611.92400914
17Cysteine and methionine metabolism_Homo sapiens_hsa002701.85915557
18PPAR signaling pathway_Homo sapiens_hsa033201.68401285
19Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.68158695
20Amphetamine addiction_Homo sapiens_hsa050311.66289686
21Huntingtons disease_Homo sapiens_hsa050161.59129710
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.55324538
23Carbohydrate digestion and absorption_Homo sapiens_hsa049731.52891887
24Carbon metabolism_Homo sapiens_hsa012001.46865146
25Renin secretion_Homo sapiens_hsa049241.41811771
26Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.31914343
27Cardiac muscle contraction_Homo sapiens_hsa042601.23408376
28Fructose and mannose metabolism_Homo sapiens_hsa000511.22131607
29Glycerophospholipid metabolism_Homo sapiens_hsa005641.13893671
30mRNA surveillance pathway_Homo sapiens_hsa030151.10562251
31Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.09898497
32Fat digestion and absorption_Homo sapiens_hsa049751.04378088
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.03078070
34Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02933410
35RNA transport_Homo sapiens_hsa030131.02395168
36Biosynthesis of amino acids_Homo sapiens_hsa012301.01691333
37Purine metabolism_Homo sapiens_hsa002300.98221762
38Ether lipid metabolism_Homo sapiens_hsa005650.98090658
39Fatty acid metabolism_Homo sapiens_hsa012120.97590981
40Long-term potentiation_Homo sapiens_hsa047200.94834775
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94578484
42Fatty acid degradation_Homo sapiens_hsa000710.91787510
43Antigen processing and presentation_Homo sapiens_hsa046120.91665967
44Mineral absorption_Homo sapiens_hsa049780.87801528
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87739102
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87350284
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81765415
48Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.80064793
49Glutathione metabolism_Homo sapiens_hsa004800.79051901
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.78780885
51Collecting duct acid secretion_Homo sapiens_hsa049660.72946767
52ABC transporters_Homo sapiens_hsa020100.72288537
53Chemical carcinogenesis_Homo sapiens_hsa052040.68165460
54Central carbon metabolism in cancer_Homo sapiens_hsa052300.64396201
55cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63536903
56VEGF signaling pathway_Homo sapiens_hsa043700.61272420
57Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59975050
58Estrogen signaling pathway_Homo sapiens_hsa049150.59858266
59Calcium signaling pathway_Homo sapiens_hsa040200.59038389
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54888048
61Arachidonic acid metabolism_Homo sapiens_hsa005900.45202388
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43469516
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.43383728
64Systemic lupus erythematosus_Homo sapiens_hsa053220.42350521
65Inositol phosphate metabolism_Homo sapiens_hsa005620.42123107
66Insulin secretion_Homo sapiens_hsa049110.41820129
67AMPK signaling pathway_Homo sapiens_hsa041520.41569399
68N-Glycan biosynthesis_Homo sapiens_hsa005100.39527499
69Metabolic pathways_Homo sapiens_hsa011000.38346254
70Bile secretion_Homo sapiens_hsa049760.37425413
71Thyroid hormone synthesis_Homo sapiens_hsa049180.37162604
72Legionellosis_Homo sapiens_hsa051340.34113296
73B cell receptor signaling pathway_Homo sapiens_hsa046620.33630624
74Hedgehog signaling pathway_Homo sapiens_hsa043400.33484967
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31014144
76Endocytosis_Homo sapiens_hsa041440.29095165
77Synaptic vesicle cycle_Homo sapiens_hsa047210.28464637
78Renin-angiotensin system_Homo sapiens_hsa046140.25223991
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24643909
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.23614726
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.23351545
82Pyrimidine metabolism_Homo sapiens_hsa002400.23062850
83Circadian entrainment_Homo sapiens_hsa047130.22557608
84Wnt signaling pathway_Homo sapiens_hsa043100.21954184
85Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.20992804
86Pancreatic secretion_Homo sapiens_hsa049720.20893882
87Taste transduction_Homo sapiens_hsa047420.20724869
88Homologous recombination_Homo sapiens_hsa034400.20450807
89Cell cycle_Homo sapiens_hsa041100.20113088
90Retinol metabolism_Homo sapiens_hsa008300.19640097
91cAMP signaling pathway_Homo sapiens_hsa040240.18814691
92Protein digestion and absorption_Homo sapiens_hsa049740.18178277
93Sulfur metabolism_Homo sapiens_hsa009200.18027735
94Salivary secretion_Homo sapiens_hsa049700.17015188
95RNA degradation_Homo sapiens_hsa030180.16640131
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.15894881
97Alcoholism_Homo sapiens_hsa050340.15527430
98Viral carcinogenesis_Homo sapiens_hsa052030.14569636
99Glutamatergic synapse_Homo sapiens_hsa047240.14227381
100Gastric acid secretion_Homo sapiens_hsa049710.13676877

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »