CETN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Caltractin belongs to a family of calcium-binding proteins and is a structural component of the centrosome. The high level of conservation from algae to humans and its association with the centrosome suggested that caltractin plays a fundamental role in the structure and function of the microtubule-organizing center, possibly required for the proper duplication and segregation of the centrosome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1left/right pattern formation (GO:0060972)7.69670547
2regulation of cilium movement (GO:0003352)6.89193382
3GTP biosynthetic process (GO:0006183)6.85551188
4axonemal dynein complex assembly (GO:0070286)6.60826067
5cilium movement (GO:0003341)6.39502546
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.21127167
7UTP biosynthetic process (GO:0006228)5.89994085
8ATP synthesis coupled proton transport (GO:0015986)5.88654896
9energy coupled proton transport, down electrochemical gradient (GO:0015985)5.88654896
10axoneme assembly (GO:0035082)5.79538390
11mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.30041858
12nucleoside diphosphate phosphorylation (GO:0006165)5.22925991
13guanosine-containing compound biosynthetic process (GO:1901070)5.21104203
14UTP metabolic process (GO:0046051)5.09108602
15CTP biosynthetic process (GO:0006241)5.02476716
16CTP metabolic process (GO:0046036)5.02476716
17microtubule bundle formation (GO:0001578)4.74779947
18intraciliary transport (GO:0042073)4.66884418
19primary alcohol catabolic process (GO:0034310)4.66112237
20epithelial cilium movement (GO:0003351)4.61458764
21cilium or flagellum-dependent cell motility (GO:0001539)4.61027629
22respiratory electron transport chain (GO:0022904)4.54139615
23electron transport chain (GO:0022900)4.49849204
24pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)4.44606472
25mitochondrial respiratory chain complex I assembly (GO:0032981)4.36424469
26NADH dehydrogenase complex assembly (GO:0010257)4.36424469
27mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.36424469
28ribosomal small subunit biogenesis (GO:0042274)4.28544776
29protein neddylation (GO:0045116)4.24447182
30epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.24286792
31pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)4.21398339
32regulation of microtubule-based movement (GO:0060632)4.20319799
33cellular component assembly involved in morphogenesis (GO:0010927)4.19906584
34microtubule-based movement (GO:0007018)4.17907603
35protein complex biogenesis (GO:0070271)4.13211453
36establishment of protein localization to mitochondrial membrane (GO:0090151)4.03119809
37ribosomal small subunit assembly (GO:0000028)4.01280967
38cotranslational protein targeting to membrane (GO:0006613)3.98703962
39pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.93029086
40chaperone-mediated protein transport (GO:0072321)3.89702796
41SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.88688161
42protein targeting to ER (GO:0045047)3.87309904
43proteasome assembly (GO:0043248)3.86366717
44viral transcription (GO:0019083)3.85642148
45purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.82674362
46vitamin transmembrane transport (GO:0035461)3.82014985
47pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.74472152
48protein localization to endoplasmic reticulum (GO:0070972)3.74396770
49mitochondrial respiratory chain complex assembly (GO:0033108)3.71660171
50purine nucleoside triphosphate biosynthetic process (GO:0009145)3.71211670
51translational termination (GO:0006415)3.69314647
52establishment of protein localization to endoplasmic reticulum (GO:0072599)3.67463198
53ventricular system development (GO:0021591)3.63351729
54cell projection assembly (GO:0030031)3.59974519
55protein localization to cilium (GO:0061512)3.54592729
56establishment of planar polarity (GO:0001736)3.54048749
57establishment of tissue polarity (GO:0007164)3.54048749
58microtubule depolymerization (GO:0007019)3.52385328
59diterpenoid biosynthetic process (GO:0016102)3.51657940
60lung epithelium development (GO:0060428)3.47349848
61left/right axis specification (GO:0070986)3.42443118
62ethanol metabolic process (GO:0006067)3.42261321
63ribonucleoside triphosphate biosynthetic process (GO:0009201)3.40678630
64lateral sprouting from an epithelium (GO:0060601)3.40538398
65respiratory chain complex IV assembly (GO:0008535)3.37358256
66deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.37169690
67smoothened signaling pathway (GO:0007224)3.35987191
68cilium organization (GO:0044782)3.30806474
69determination of left/right symmetry (GO:0007368)3.27695772
70terpenoid biosynthetic process (GO:0016114)3.26171605
71cilium assembly (GO:0042384)3.25122577
72cullin deneddylation (GO:0010388)3.15201373
73nucleotide phosphorylation (GO:0046939)3.14351352
74determination of bilateral symmetry (GO:0009855)3.13418541
75maturation of SSU-rRNA (GO:0030490)3.10670895
76specification of symmetry (GO:0009799)3.09275631
77glutathione derivative biosynthetic process (GO:1901687)3.08972965
78glutathione derivative metabolic process (GO:1901685)3.08972965
79pyrimidine-containing compound transmembrane transport (GO:0072531)3.07803328
80nucleoside triphosphate biosynthetic process (GO:0009142)3.06984487
81cilium morphogenesis (GO:0060271)3.06371602
82motile cilium assembly (GO:0044458)3.05660320
83lateral ventricle development (GO:0021670)3.05582654
84inner mitochondrial membrane organization (GO:0007007)3.05239131
85RNA capping (GO:0036260)3.03464602
867-methylguanosine RNA capping (GO:0009452)3.03464602
87aldehyde catabolic process (GO:0046185)3.03438466
88translational elongation (GO:0006414)3.03303496
89regulation of cellular amino acid metabolic process (GO:0006521)3.00918080
90negative regulation of T cell differentiation in thymus (GO:0033085)2.99797401
917-methylguanosine mRNA capping (GO:0006370)2.99693695
92establishment of viral latency (GO:0019043)2.99310612
93pyrimidine ribonucleoside biosynthetic process (GO:0046132)2.98900797
94viral life cycle (GO:0019058)2.98502295
95antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.98036507
96establishment of integrated proviral latency (GO:0075713)2.96877589
97ATP biosynthetic process (GO:0006754)2.96138126
98sperm capacitation (GO:0048240)2.95055967
99cellular protein complex disassembly (GO:0043624)2.94636911
100response to xenobiotic stimulus (GO:0009410)2.94553668
101signal peptide processing (GO:0006465)2.93145443
102termination of RNA polymerase III transcription (GO:0006386)2.92131090
103transcription elongation from RNA polymerase III promoter (GO:0006385)2.92131090
104pyrimidine ribonucleotide biosynthetic process (GO:0009220)2.91271565
105negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.91055997
106nonmotile primary cilium assembly (GO:0035058)2.90726207
107ribosomal large subunit biogenesis (GO:0042273)2.89954113
108protein deneddylation (GO:0000338)2.89651729
109microtubule polymerization or depolymerization (GO:0031109)2.89325517
110cytochrome complex assembly (GO:0017004)2.88531114
111establishment of apical/basal cell polarity (GO:0035089)2.86787729
112establishment or maintenance of monopolar cell polarity (GO:0061339)2.86292031
113establishment of monopolar cell polarity (GO:0061162)2.86292031
114central nervous system myelination (GO:0022010)2.85949982
115axon ensheathment in central nervous system (GO:0032291)2.85949982
116mannosylation (GO:0097502)2.84951743
117apical protein localization (GO:0045176)2.83949190
118hydrogen ion transmembrane transport (GO:1902600)2.81160158
119translation (GO:0006412)2.80179861
120dopamine transport (GO:0015872)2.79317032
121DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.78915407
122nucleoside diphosphate metabolic process (GO:0009132)2.78854626
123antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.75112953
124pyrimidine nucleotide biosynthetic process (GO:0006221)2.75000168
125sperm motility (GO:0030317)2.74470308
126retinoic acid metabolic process (GO:0042573)2.72258663
127intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.72145951
128signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.72145951
129one-carbon compound transport (GO:0019755)2.71005005
130signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.69991747
131signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.69991747
132signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.69991747
133positive regulation of smoothened signaling pathway (GO:0045880)2.68061954
134negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.65737425
135negative regulation of ligase activity (GO:0051352)2.65737425
136glomerular epithelial cell development (GO:0072310)2.64004107
137DNA ligation (GO:0006266)2.61615674
138positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.61326857
139sequestering of actin monomers (GO:0042989)2.60294810
140proton transport (GO:0015992)2.60016115
141* microtubule-based process (GO:0007017)2.54126129
142ethanol oxidation (GO:0006069)2.53448087
143cytoplasmic microtubule organization (GO:0031122)2.45878984
144hydrogen peroxide catabolic process (GO:0042744)2.44953580
145retinal rod cell development (GO:0046548)2.42633570
146asymmetric protein localization (GO:0008105)2.41781573
147* organelle assembly (GO:0070925)2.36767551
148retinol metabolic process (GO:0042572)2.36555340
149heart looping (GO:0001947)2.32905390
150neuron fate determination (GO:0048664)2.29025384
151embryonic heart tube morphogenesis (GO:0003143)2.28600493
152organelle disassembly (GO:1903008)2.26307312
153primary alcohol metabolic process (GO:0034308)2.26232738
154* centriole assembly (GO:0098534)2.25737158
155intra-S DNA damage checkpoint (GO:0031573)2.22171247
156regulation of smoothened signaling pathway (GO:0008589)2.21764873
157limb development (GO:0060173)2.20643671
158appendage development (GO:0048736)2.20643671
159photoreceptor cell maintenance (GO:0045494)2.17917924
160carnitine metabolic process (GO:0009437)2.17714971
161regulation of autophagic vacuole assembly (GO:2000785)2.17540775

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human5.33166485
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.04843719
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.40864057
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.84870583
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.72331455
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.32750955
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.81735795
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.60971026
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.56330362
10CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.54994997
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.54274263
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.52031863
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.40778669
14TAF15_26573619_Chip-Seq_HEK293_Human2.37484270
15ELK1_19687146_ChIP-ChIP_HELA_Human2.26820168
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.26220594
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.21572767
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.14579314
19PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.12457212
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.09403098
21RBPJ_22232070_ChIP-Seq_NCS_Mouse2.06715388
22BMI1_23680149_ChIP-Seq_NPCS_Mouse2.04314017
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.04021554
24PIAS1_25552417_ChIP-Seq_VCAP_Human2.02311688
25ELF1_17652178_ChIP-ChIP_JURKAT_Human1.99728261
26IRF1_19129219_ChIP-ChIP_H3396_Human1.99004277
27VDR_23849224_ChIP-Seq_CD4+_Human1.93541468
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.92112061
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86960092
30SRF_21415370_ChIP-Seq_HL-1_Mouse1.86323890
31FUS_26573619_Chip-Seq_HEK293_Human1.82915112
32VDR_22108803_ChIP-Seq_LS180_Human1.76986664
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.71930788
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70970753
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.61563949
36MYC_18555785_ChIP-Seq_MESCs_Mouse1.58497923
37HOXB4_20404135_ChIP-ChIP_EML_Mouse1.56330563
38FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.55073657
39EWS_26573619_Chip-Seq_HEK293_Human1.54003975
40FOXM1_26456572_ChIP-Seq_MCF-7_Human1.53241480
41P300_19829295_ChIP-Seq_ESCs_Human1.53057668
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52850872
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.50749314
44RNF2_27304074_Chip-Seq_NSC_Mouse1.49988863
45CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45747876
46GBX2_23144817_ChIP-Seq_PC3_Human1.44935928
47FOXP3_21729870_ChIP-Seq_TREG_Human1.39990684
48ELK1_22589737_ChIP-Seq_MCF10A_Human1.39782732
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.39413596
50ER_23166858_ChIP-Seq_MCF-7_Human1.39311314
51NR3C1_21868756_ChIP-Seq_MCF10A_Human1.38207376
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.37448992
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37345449
54TTF2_22483619_ChIP-Seq_HELA_Human1.36447250
55MYC_18358816_ChIP-ChIP_MESCs_Mouse1.36317379
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31837178
57SMAD4_21799915_ChIP-Seq_A2780_Human1.31211629
58DCP1A_22483619_ChIP-Seq_HELA_Human1.29873355
59PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.29376296
60EZH2_22144423_ChIP-Seq_EOC_Human1.28614384
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27060006
62RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.24097848
63CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.22541440
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21829000
65E2F1_18555785_ChIP-Seq_MESCs_Mouse1.21762363
66PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21040700
67MYC_18940864_ChIP-ChIP_HL60_Human1.20774488
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18834695
69FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.18718122
70TP53_18474530_ChIP-ChIP_U2OS_Human1.18446891
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17022052
72PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.16786680
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14895333
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.14775845
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14065941
76YY1_21170310_ChIP-Seq_MESCs_Mouse1.12998572
77DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.12699165
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12429893
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11882928
80TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11548534
81MYC_19030024_ChIP-ChIP_MESCs_Mouse1.10980410
82MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10148446
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.09847072
84RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09482678
85KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09321771
86TAL1_26923725_Chip-Seq_HPCs_Mouse1.08164860
87CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.07765645
88STAT3_18555785_Chip-Seq_ESCs_Mouse1.07122343
89EED_16625203_ChIP-ChIP_MESCs_Mouse1.05933602
90P53_22387025_ChIP-Seq_ESCs_Mouse1.05536738
91NFE2_27457419_Chip-Seq_LIVER_Mouse1.05279409
92DROSHA_22980978_ChIP-Seq_HELA_Human1.05259480
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05037924
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04831511
95PHF8_20622853_ChIP-Seq_HELA_Human1.04006327
96PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03592173
97GATA1_26923725_Chip-Seq_HPCs_Mouse1.03496198
98SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02818340
99AHR_22903824_ChIP-Seq_MCF-7_Human1.02306819
100SUZ12_18555785_Chip-Seq_ESCs_Mouse1.01888298
101EZH2_27294783_Chip-Seq_NPCs_Mouse1.01864882
102EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01516310
103EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01501952
104GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01183109
105NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.00523277
106ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00033747
107FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99605179
108FOXA1_25329375_ChIP-Seq_VCAP_Human0.99605179
109TCF4_22108803_ChIP-Seq_LS180_Human0.99143354
110ZNF274_21170338_ChIP-Seq_K562_Hela0.98956457
111SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.98814059
112ERG_20517297_ChIP-Seq_VCAP_Human0.98453993
113FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.98395280
114ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98097412
115P300_18555785_Chip-Seq_ESCs_Mouse0.97602793
116EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.97161882
117NANOG_16153702_ChIP-ChIP_HESCs_Human0.96556547
118RUNX1_27457419_Chip-Seq_LIVER_Mouse0.96229857
119AR_20517297_ChIP-Seq_VCAP_Human0.95907833
120IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.95428293
121TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94668789
122WT1_19549856_ChIP-ChIP_CCG9911_Human0.94199880
123IGF1R_20145208_ChIP-Seq_DFB_Human0.94140413
124NMYC_18555785_Chip-Seq_ESCs_Mouse0.94073993
125THAP11_20581084_ChIP-Seq_MESCs_Mouse0.94020945
126CMYC_18555785_Chip-Seq_ESCs_Mouse0.93926723
127PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.93659313
128SOX2_18555785_Chip-Seq_ESCs_Mouse0.93288556
129ETV1_20927104_ChIP-Seq_GIST48_Human0.93263691
130PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.92662605
131AR_25329375_ChIP-Seq_VCAP_Human0.92645247
132ARNT_22903824_ChIP-Seq_MCF-7_Human0.91917874
133ZFX_18555785_Chip-Seq_ESCs_Mouse0.91597373
134EZH2_27304074_Chip-Seq_ESCs_Mouse0.91142799
135BP1_19119308_ChIP-ChIP_Hs578T_Human0.90905850
136JUN_21703547_ChIP-Seq_K562_Human0.90525279
137FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.89686811
138BCAT_22108803_ChIP-Seq_LS180_Human0.89129215
139XRN2_22483619_ChIP-Seq_HELA_Human0.89087278
140SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.87837529
141E2F4_17652178_ChIP-ChIP_JURKAT_Human0.87640023
142E2F1_18555785_Chip-Seq_ESCs_Mouse0.87094390
143SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.86950551
144SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.86922997
145STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.86715222
146RUNX2_22187159_ChIP-Seq_PCA_Human0.86448536
147CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.86325252
148TDRD3_21172665_ChIP-Seq_MCF-7_Human0.86207703
149EZH2_27294783_Chip-Seq_ESCs_Mouse0.85933527
150AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85352559
151SALL1_21062744_ChIP-ChIP_HESCs_Human0.85032854
152CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.84911015
153TBL1_22424771_ChIP-Seq_293T_Human0.84561618
154CDX2_20551321_ChIP-Seq_CACO-2_Human0.83773358
155HNFA_21074721_ChIP-Seq_CACO-2_Human0.83086523
156CBP_21632823_ChIP-Seq_H3396_Human0.80249329
157ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.80070979
158TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79856976
159POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.79856976
160RBPJ_21746931_ChIP-Seq_IB4_Human0.79493435

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.85761694
2MP0009379_abnormal_foot_pigmentation3.70902269
3MP0000566_synostosis3.66998781
4MP0008875_abnormal_xenobiotic_pharmacok3.37003008
5MP0003880_abnormal_central_pattern3.24116925
6MP0010030_abnormal_orbit_morphology3.14900697
7MP0001984_abnormal_olfaction2.95695670
8MP0001529_abnormal_vocalization2.82726023
9MP0001905_abnormal_dopamine_level2.81097948
10MP0002163_abnormal_gland_morphology2.54264383
11MP0005379_endocrine/exocrine_gland_phen2.49000021
12MP0001986_abnormal_taste_sensitivity2.41254059
13MP0009780_abnormal_chondrocyte_physiolo2.29527287
14MP0006292_abnormal_olfactory_placode2.26385448
15MP0002638_abnormal_pupillary_reflex2.25134954
16MP0001188_hyperpigmentation2.15619553
17MP0006276_abnormal_autonomic_nervous2.15168972
18MP0000372_irregular_coat_pigmentation1.92703891
19MP0005646_abnormal_pituitary_gland1.87350902
20MP0003724_increased_susceptibility_to1.86012197
21MP0002132_abnormal_respiratory_system1.84062720
22MP0005409_darkened_coat_color1.83492961
23MP0004381_abnormal_hair_follicle1.79959484
24MP0002938_white_spotting1.76197690
25MP0001293_anophthalmia1.74761937
26MP0006072_abnormal_retinal_apoptosis1.73865507
27MP0002233_abnormal_nose_morphology1.71268448
28MP0003878_abnormal_ear_physiology1.70923663
29MP0005377_hearing/vestibular/ear_phenot1.70923663
30MP0001968_abnormal_touch/_nociception1.64652441
31MP0008789_abnormal_olfactory_epithelium1.63199804
32MP0002736_abnormal_nociception_after1.60947926
33MP0002876_abnormal_thyroid_physiology1.60037917
34MP0002734_abnormal_mechanical_nocicepti1.46835798
35MP0001346_abnormal_lacrimal_gland1.46066437
36MP0003937_abnormal_limbs/digits/tail_de1.46064250
37MP0004019_abnormal_vitamin_homeostasis1.45301274
38MP0008004_abnormal_stomach_pH1.45184561
39MP0000383_abnormal_hair_follicle1.44822739
40MP0003283_abnormal_digestive_organ1.44169815
41MP0008057_abnormal_DNA_replication1.41929041
42MP0005248_abnormal_Harderian_gland1.41840360
43MP0002822_catalepsy1.40016470
44MP0004043_abnormal_pH_regulation1.38952918
45MP0009745_abnormal_behavioral_response1.38815150
46MP0002909_abnormal_adrenal_gland1.34516106
47MP0004142_abnormal_muscle_tone1.33725563
48MP0002102_abnormal_ear_morphology1.33308068
49MP0002277_abnormal_respiratory_mucosa1.31663703
50MP0000631_abnormal_neuroendocrine_gland1.31273303
51MP0001485_abnormal_pinna_reflex1.30861545
52MP0003186_abnormal_redox_activity1.30246558
53MP0002160_abnormal_reproductive_system1.29750264
54MP0002272_abnormal_nervous_system1.27928116
55MP0001440_abnormal_grooming_behavior1.26890568
56MP0010386_abnormal_urinary_bladder1.26415081
57MP0005671_abnormal_response_to1.25934110
58MP0002735_abnormal_chemical_nociception1.24451032
59MP0002653_abnormal_ependyma_morphology1.23506259
60MP0002572_abnormal_emotion/affect_behav1.22161657
61MP0000778_abnormal_nervous_system1.22020487
62MP0005253_abnormal_eye_physiology1.21086997
63MP0002148_abnormal_hypersensitivity_rea1.20807312
64MP0005551_abnormal_eye_electrophysiolog1.20176339
65MP0005645_abnormal_hypothalamus_physiol1.19839202
66MP0003890_abnormal_embryonic-extraembry1.18804143
67MP0003763_abnormal_thymus_physiology1.18607797
68MP0002234_abnormal_pharynx_morphology1.17952511
69MP0003942_abnormal_urinary_system1.16875510
70MP0001970_abnormal_pain_threshold1.16753686
71MP0002064_seizures1.16622523
72MP0005499_abnormal_olfactory_system1.14103719
73MP0005394_taste/olfaction_phenotype1.14103719
74MP0002249_abnormal_larynx_morphology1.13313373
75MP0004133_heterotaxia1.13264439
76MP0001299_abnormal_eye_distance/1.13150794
77MP0004782_abnormal_surfactant_physiolog1.11105615
78MP0005171_absent_coat_pigmentation1.09435864
79MP0009046_muscle_twitch1.09428787
80MP0002751_abnormal_autonomic_nervous1.07959443
81MP0005075_abnormal_melanosome_morpholog1.07236312
82MP0000026_abnormal_inner_ear1.06849589
83MP0003011_delayed_dark_adaptation1.06309449
84MP0010678_abnormal_skin_adnexa1.05732754
85MP0002095_abnormal_skin_pigmentation1.03927253
86MP0002557_abnormal_social/conspecific_i1.03898573
87MP0004742_abnormal_vestibular_system1.03248088
88MP0009053_abnormal_anal_canal1.02730817
89MP0005503_abnormal_tendon_morphology1.00170424
90MP0005389_reproductive_system_phenotype0.99998342
91MP0005084_abnormal_gallbladder_morpholo0.98805583
92MP0001286_abnormal_eye_development0.95167481
93MP0003122_maternal_imprinting0.95002087
94MP0000534_abnormal_ureter_morphology0.94979507
95MP0003861_abnormal_nervous_system0.94173241
96MP0000049_abnormal_middle_ear0.93698021
97MP0005423_abnormal_somatic_nervous0.92637024
98MP0004147_increased_porphyrin_level0.91411998
99MP0005391_vision/eye_phenotype0.91307055
100MP0008058_abnormal_DNA_repair0.91151607
101MP0001963_abnormal_hearing_physiology0.90985127
102MP0001502_abnormal_circadian_rhythm0.89343750
103MP0001501_abnormal_sleep_pattern0.88842366
104MP0001486_abnormal_startle_reflex0.88805033
105MP0005195_abnormal_posterior_eye0.88635031
106MP0000955_abnormal_spinal_cord0.88460928
107MP0000015_abnormal_ear_pigmentation0.87808392
108MP0003635_abnormal_synaptic_transmissio0.87467625
109MP0002928_abnormal_bile_duct0.86633478
110MP0000762_abnormal_tongue_morphology0.86631101
111MP0002067_abnormal_sensory_capabilities0.86395824
112MP0003718_maternal_effect0.86123597
113MP0003938_abnormal_ear_development0.85331004
114MP0000579_abnormal_nail_morphology0.84511477
115MP0001324_abnormal_eye_pigmentation0.84116841
116MP0002733_abnormal_thermal_nociception0.83465139
117MP0000920_abnormal_myelination0.83200164
118MP0003119_abnormal_digestive_system0.83003046
119MP0002116_abnormal_craniofacial_bone0.82740720
120MP0003806_abnormal_nucleotide_metabolis0.81983717
121MP0003755_abnormal_palate_morphology0.81735266
122MP0009785_altered_susceptibility_to0.81353572
123MP0002063_abnormal_learning/memory/cond0.80837556
124MP0000537_abnormal_urethra_morphology0.79625976
125MP0008932_abnormal_embryonic_tissue0.77283908
126MP0002752_abnormal_somatic_nervous0.77041525
127MP0001929_abnormal_gametogenesis0.76885398
128MP0005083_abnormal_biliary_tract0.76691463
129MP0003698_abnormal_male_reproductive0.76685825
130MP0002092_abnormal_eye_morphology0.76587782
131MP0004924_abnormal_behavior0.75907264
132MP0005386_behavior/neurological_phenoty0.75907264
133MP0006036_abnormal_mitochondrial_physio0.75804352
134MP0002697_abnormal_eye_size0.75729618
135MP0001879_abnormal_lymphatic_vessel0.75259864
136MP0005000_abnormal_immune_tolerance0.74854557
137MP0002084_abnormal_developmental_patter0.74757653
138MP0008872_abnormal_physiological_respon0.74233630
139MP0000613_abnormal_salivary_gland0.72914469
140MP0009697_abnormal_copulation0.72901022
141MP0005408_hypopigmentation0.72875233
142MP0002152_abnormal_brain_morphology0.72852398
143MP0001853_heart_inflammation0.72616709
144MP0005174_abnormal_tail_pigmentation0.72566010
145MP0000681_abnormal_thyroid_gland0.72548437
146MP0001542_abnormal_bone_strength0.72299800
147MP0005187_abnormal_penis_morphology0.71769005
148MP0004885_abnormal_endolymph0.71748824
149MP0002295_abnormal_pulmonary_circulatio0.70895743
150MP0005623_abnormal_meninges_morphology0.68917800
151MP0003941_abnormal_skin_development0.68443588
152MP0002282_abnormal_trachea_morphology0.68419591
153MP0003634_abnormal_glial_cell0.68314089
154MP0001664_abnormal_digestion0.67962063

Predicted human phenotypes

RankGene SetZ-score
1Abnormal ciliary motility (HP:0012262)7.71228704
2Abnormal respiratory motile cilium physiology (HP:0012261)7.22090520
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.31082622
4Abnormal respiratory epithelium morphology (HP:0012253)6.12623092
5Abnormal respiratory motile cilium morphology (HP:0005938)6.12623092
6Rhinitis (HP:0012384)6.05978905
7Acute necrotizing encephalopathy (HP:0006965)4.70749106
8Mitochondrial inheritance (HP:0001427)4.10777410
9Abnormal mitochondria in muscle tissue (HP:0008316)4.08433378
10Progressive macrocephaly (HP:0004481)4.05527346
11Abnormality of the nasal mucosa (HP:0000433)4.03837578
12Absent/shortened dynein arms (HP:0200106)3.99658141
13Dynein arm defect of respiratory motile cilia (HP:0012255)3.99658141
14True hermaphroditism (HP:0010459)3.90782847
15Medial flaring of the eyebrow (HP:0010747)3.89572593
16Pancreatic fibrosis (HP:0100732)3.74562979
17Infertility (HP:0000789)3.73084528
18Bronchiectasis (HP:0002110)3.66039308
19Acute encephalopathy (HP:0006846)3.65013361
20Gait imbalance (HP:0002141)3.62113421
21Congenital primary aphakia (HP:0007707)3.61150952
22Increased hepatocellular lipid droplets (HP:0006565)3.48037327
23Chronic sinusitis (HP:0011109)3.46028107
24Nephrogenic diabetes insipidus (HP:0009806)3.43857052
25Increased CSF lactate (HP:0002490)3.38841191
26Chronic bronchitis (HP:0004469)3.21528368
27Hepatocellular necrosis (HP:0001404)3.13914513
28Renal Fanconi syndrome (HP:0001994)3.12918966
29Male infertility (HP:0003251)3.02268375
30Pancreatic cysts (HP:0001737)2.91621042
31Genital tract atresia (HP:0001827)2.90417335
32Vaginal atresia (HP:0000148)2.86048334
33Lipid accumulation in hepatocytes (HP:0006561)2.82298027
34Exercise intolerance (HP:0003546)2.78686846
35Parakeratosis (HP:0001036)2.74962294
36Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.73636880
37Recurrent otitis media (HP:0000403)2.72598321
38Optic disc pallor (HP:0000543)2.69387372
39Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.67946204
40Abnormality of cells of the erythroid lineage (HP:0012130)2.67238987
41Atelectasis (HP:0100750)2.60241970
42Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.58187108
43Hepatic necrosis (HP:0002605)2.52828471
443-Methylglutaconic aciduria (HP:0003535)2.47786261
45Poor coordination (HP:0002370)2.47276139
46Hypothermia (HP:0002045)2.44039227
47Occipital encephalocele (HP:0002085)2.42112400
48Recurrent sinusitis (HP:0011108)2.41270795
49Exertional dyspnea (HP:0002875)2.40361735
50Chronic hepatic failure (HP:0100626)2.36925757
51Abnormality of midbrain morphology (HP:0002418)2.36483637
52Molar tooth sign on MRI (HP:0002419)2.36483637
53Abnormality of renal resorption (HP:0011038)2.35422891
54Median cleft lip (HP:0000161)2.34749785
55Abnormal number of erythroid precursors (HP:0012131)2.32011502
56Increased serum pyruvate (HP:0003542)2.30916424
57Abnormality of glycolysis (HP:0004366)2.30916424
58Congenital hepatic fibrosis (HP:0002612)2.26634599
59Nephronophthisis (HP:0000090)2.25517905
60Male pseudohermaphroditism (HP:0000037)2.23651569
61Leukodystrophy (HP:0002415)2.22616823
62Chronic otitis media (HP:0000389)2.20102032
63Respiratory failure (HP:0002878)2.19390560
64Respiratory difficulties (HP:0002880)2.19104761
65Increased intramyocellular lipid droplets (HP:0012240)2.17627877
66Supernumerary spleens (HP:0009799)2.14653599
67Preaxial hand polydactyly (HP:0001177)2.13705523
68Decreased activity of mitochondrial respiratory chain (HP:0008972)2.11027023
69Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.11027023
70Aplasia/Hypoplasia of the lens (HP:0008063)2.10468303
71Tubulointerstitial nephritis (HP:0001970)2.07908462
72Bronchitis (HP:0012387)2.07605457
73Sclerocornea (HP:0000647)2.06961901
74Anencephaly (HP:0002323)2.06081256
75Hyperactive renin-angiotensin system (HP:0000841)2.02443374
76Increased serum lactate (HP:0002151)1.99355190
77Type I transferrin isoform profile (HP:0003642)1.98098187
78Lactic acidosis (HP:0003128)1.96990756
79Cerebral edema (HP:0002181)1.96503256
80Postaxial foot polydactyly (HP:0001830)1.96385557
81Asplenia (HP:0001746)1.94157407
82Tubular atrophy (HP:0000092)1.91999150
83Aplasia/Hypoplasia of the tongue (HP:0010295)1.90529541
84Furrowed tongue (HP:0000221)1.90145060
85Abnormality of dentin (HP:0010299)1.89091446
86Oculomotor apraxia (HP:0000657)1.86714442
87Macrocytic anemia (HP:0001972)1.85281945
88Nasal polyposis (HP:0100582)1.83267086
89Congenital ichthyosiform erythroderma (HP:0007431)1.80392957
90Aplasia/Hypoplasia of the sacrum (HP:0008517)1.78462139
9111 pairs of ribs (HP:0000878)1.77589604
92Broad foot (HP:0001769)1.76915287
93Abnormality of the renal medulla (HP:0100957)1.76372948
94Bell-shaped thorax (HP:0001591)1.72569934
95Sex reversal (HP:0012245)1.71779724
96Abnormal sex determination (HP:0012244)1.71779724
97Aplasia/Hypoplasia of the spleen (HP:0010451)1.71738089
98Postaxial hand polydactyly (HP:0001162)1.71465351
99Abnormality of permanent molar morphology (HP:0011071)1.70096272
100Abnormality of the dental root (HP:0006486)1.70096272
101Taurodontia (HP:0000679)1.70096272
102Abnormal pupillary function (HP:0007686)1.69474582
103Reticulocytopenia (HP:0001896)1.69058621
104Short nail (HP:0001799)1.68079630
105Abnormality of the axillary hair (HP:0100134)1.65721625
106Abnormality of secondary sexual hair (HP:0009888)1.65721625
107Adrenal hypoplasia (HP:0000835)1.65251532
108Cystic liver disease (HP:0006706)1.65187688
109Limb dystonia (HP:0002451)1.63901442
110X-linked dominant inheritance (HP:0001423)1.63704977
111Aplasia/hypoplasia of the uterus (HP:0008684)1.63630365
112Nephropathy (HP:0000112)1.60507859
113Retinal dysplasia (HP:0007973)1.60169875
114Aplastic anemia (HP:0001915)1.59660720
115Asthma (HP:0002099)1.59475907
116Tubulointerstitial abnormality (HP:0001969)1.56539334
117Abnormality of molar (HP:0011077)1.52453592
118Abnormality of molar morphology (HP:0011070)1.52453592
119Abnormality of the dental pulp (HP:0006479)1.40873545
120Absent frontal sinuses (HP:0002688)1.40240058
121Aganglionic megacolon (HP:0002251)1.39592482
122Narrow forehead (HP:0000341)1.36034795
123Abnormality of abdominal situs (HP:0011620)1.35968890
124Abdominal situs inversus (HP:0003363)1.35968890
125Anophthalmia (HP:0000528)1.33925858
126Renal salt wasting (HP:0000127)1.33829143
127Specific learning disability (HP:0001328)1.29261991
128Prominent nasal bridge (HP:0000426)1.28012500
129Stage 5 chronic kidney disease (HP:0003774)1.27864031
130Broad distal phalanx of finger (HP:0009836)1.26118629
131Holoprosencephaly (HP:0001360)1.25923335
132Tubulointerstitial fibrosis (HP:0005576)1.25522584
133Multicystic kidney dysplasia (HP:0000003)1.24337408
134Decreased testicular size (HP:0008734)1.23978911
135Bifid scrotum (HP:0000048)1.22082467
136Renal dysplasia (HP:0000110)1.20848163
137Abnormality of the renal cortex (HP:0011035)1.20522924
138Retinitis pigmentosa (HP:0000510)1.20515352
139Myokymia (HP:0002411)1.20151412
140Abnormal drinking behavior (HP:0030082)1.18808226
141Polydipsia (HP:0001959)1.18808226
142Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.18394927
143Abnormal biliary tract physiology (HP:0012439)1.17669708
144Bile duct proliferation (HP:0001408)1.17669708

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST43.64610681
2STK163.09750894
3MAP3K122.85097380
4MAPK152.85091405
5EPHA22.64426216
6CASK2.55560334
7VRK22.47625847
8VRK12.36953351
9PBK1.90787938
10NME11.89342773
11BCR1.88259389
12ADRBK21.86093915
13PNCK1.84315422
14GRK71.83286144
15TESK11.78350436
16NME21.75935587
17BMPR21.73596885
18MAP2K71.71519148
19EPHB21.70396907
20MAPKAPK51.70008936
21ARAF1.63928424
22TNIK1.63431981
23EIF2AK31.62446278
24BUB11.53920099
25TTK1.53610576
26MAP3K41.52039348
27SRPK11.51115108
28MKNK11.48768334
29STK241.47103509
30WEE11.46775117
31TXK1.44347410
32PIM21.42848889
33OXSR11.41888579
34STK391.40094888
35PLK21.25706109
36GRK51.20487635
37ERBB31.20129366
38MYLK1.19199440
39MKNK21.17834453
40GRK11.17241773
41MAPKAPK31.16909829
42MAPK131.16770828
43TEC1.15085100
44PTK2B1.14962482
45BMPR1B1.13442002
46MUSK1.12469474
47LIMK11.12060689
48CDK191.09667111
49TSSK61.06491760
50CDK31.03917964
51STK38L1.02096849
52LRRK21.01180502
53DYRK31.00548610
54CDK80.96974292
55BRSK20.93540010
56DYRK20.93054905
57MAP3K20.91416555
58TRIM280.91039002
59IRAK10.90015596
60MAP4K20.87974728
61CAMK2B0.87254361
62EIF2AK10.86738507
63PLK30.86297670
64FRK0.83979269
65CSNK1G20.82938742
66PLK10.81099823
67IRAK40.80067042
68NEK60.75308340
69ADRBK10.73076881
70MINK10.72638191
71YES10.69873441
72NEK10.69788542
73EPHA30.67858689
74CAMK2A0.67719213
75PRKCE0.67644963
76RPS6KA50.67377191
77IRAK20.66785466
78CSNK1G30.66783389
79WNK40.66587647
80ILK0.66529875
81MAP2K40.66168985
82TRPM70.62924542
83TLK10.62165763
84ITK0.61449339
85FGR0.61305049
86SIK30.60576332
87CAMKK20.60353589
88SYK0.59117765
89PLK40.57856875
90UHMK10.56926128
91ZAK0.56695374
92PRKCI0.56618664
93CAMK2D0.56605241
94BRAF0.56489540
95DYRK1B0.56289898
96TESK20.56069059
97PASK0.55950818
98CDC70.55291939
99NLK0.54069540
100FES0.53852587
101BRSK10.53697856
102DYRK1A0.53610193
103CSNK2A10.53502297
104TAF10.52610077
105PRKCG0.51188778
106NTRK20.51174694
107NTRK30.50412618
108EIF2AK20.50214205
109ERBB20.49363626
110LYN0.49111455
111MAP3K140.48257522
112AURKB0.47866036
113CSNK2A20.47004036
114WNK30.46718597
115CHEK20.46012486
116EPHA40.45907166
117GRK60.45669015
118BTK0.44784233
119NTRK10.44660220
120ROCK20.43224070
121CSNK1G10.42433197
122LMTK20.42201232
123CCNB10.41344345
124MET0.39614777
125CAMK2G0.39614729
126* PRKACA0.39544854
127CSNK1E0.39341829
128RIPK40.39085513
129PHKG10.38982356
130PHKG20.38982356
131LATS10.38206202
132MARK10.36777335
133PRKCQ0.36038343
134MAPK40.35819282
135MST1R0.35740754
136RPS6KB20.35488470
137ROCK10.35058357
138PINK10.34429048
139BCKDK0.34416355
140RAF10.33970743
141INSRR0.33727726
142TGFBR10.31511002
143DMPK0.31192852
144ERBB40.30418538
145ABL20.29449620

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.71063189
2Protein export_Homo sapiens_hsa030604.10233138
3Ribosome_Homo sapiens_hsa030104.05345131
4Parkinsons disease_Homo sapiens_hsa050123.88153547
5Proteasome_Homo sapiens_hsa030503.85827498
6Huntingtons disease_Homo sapiens_hsa050163.27663664
7Alzheimers disease_Homo sapiens_hsa050103.00390681
8RNA polymerase_Homo sapiens_hsa030202.78338692
9Chemical carcinogenesis_Homo sapiens_hsa052042.67933163
10Phenylalanine metabolism_Homo sapiens_hsa003602.45283038
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.24754983
12Tyrosine metabolism_Homo sapiens_hsa003502.18035667
13Histidine metabolism_Homo sapiens_hsa003402.03539657
14beta-Alanine metabolism_Homo sapiens_hsa004101.95133412
15Pyrimidine metabolism_Homo sapiens_hsa002401.85870112
16Collecting duct acid secretion_Homo sapiens_hsa049661.77488399
17Basal transcription factors_Homo sapiens_hsa030221.62021737
18SNARE interactions in vesicular transport_Homo sapiens_hsa041301.60306902
19Spliceosome_Homo sapiens_hsa030401.58224563
20Mismatch repair_Homo sapiens_hsa034301.57041955
21Graft-versus-host disease_Homo sapiens_hsa053321.53829115
22DNA replication_Homo sapiens_hsa030301.51719783
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.49936034
24Homologous recombination_Homo sapiens_hsa034401.42302330
25* Nucleotide excision repair_Homo sapiens_hsa034201.41735750
26Basal cell carcinoma_Homo sapiens_hsa052171.40879072
27Phototransduction_Homo sapiens_hsa047441.40633724
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.40595951
29Retinol metabolism_Homo sapiens_hsa008301.39402365
30Folate biosynthesis_Homo sapiens_hsa007901.34785502
31Vibrio cholerae infection_Homo sapiens_hsa051101.34166990
32Cardiac muscle contraction_Homo sapiens_hsa042601.32842660
33Hedgehog signaling pathway_Homo sapiens_hsa043401.29808774
34Purine metabolism_Homo sapiens_hsa002301.29641329
35Rheumatoid arthritis_Homo sapiens_hsa053231.28464758
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.26385691
37Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.19504135
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.15708530
39Peroxisome_Homo sapiens_hsa041461.13605567
40RNA degradation_Homo sapiens_hsa030181.12576312
41Autoimmune thyroid disease_Homo sapiens_hsa053201.12086538
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.10531652
43Butanoate metabolism_Homo sapiens_hsa006501.10350741
44Propanoate metabolism_Homo sapiens_hsa006401.09537770
45Base excision repair_Homo sapiens_hsa034101.09505206
46Caffeine metabolism_Homo sapiens_hsa002321.08561536
47Arachidonic acid metabolism_Homo sapiens_hsa005901.06953657
48Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.06806658
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04629598
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.01875785
51Allograft rejection_Homo sapiens_hsa053300.99355746
52Steroid hormone biosynthesis_Homo sapiens_hsa001400.98913535
53Nicotine addiction_Homo sapiens_hsa050330.98724026
54Non-homologous end-joining_Homo sapiens_hsa034500.98271996
55Pyruvate metabolism_Homo sapiens_hsa006200.97351893
56Serotonergic synapse_Homo sapiens_hsa047260.95645403
57Ether lipid metabolism_Homo sapiens_hsa005650.95393873
58Tight junction_Homo sapiens_hsa045300.92046998
59Fatty acid elongation_Homo sapiens_hsa000620.91267041
60Olfactory transduction_Homo sapiens_hsa047400.91156934
61Type I diabetes mellitus_Homo sapiens_hsa049400.90742364
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.89846536
63Hippo signaling pathway_Homo sapiens_hsa043900.89022118
64Fatty acid degradation_Homo sapiens_hsa000710.86860339
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.86193546
66Sulfur metabolism_Homo sapiens_hsa009200.82095865
67Sphingolipid metabolism_Homo sapiens_hsa006000.80149144
68Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.80084374
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78342813
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78042336
71Primary immunodeficiency_Homo sapiens_hsa053400.77844024
72Phagosome_Homo sapiens_hsa041450.75015333
73Glutathione metabolism_Homo sapiens_hsa004800.73383051
74Fanconi anemia pathway_Homo sapiens_hsa034600.72519838
75Steroid biosynthesis_Homo sapiens_hsa001000.72126263
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70644423
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.68551312
78Antigen processing and presentation_Homo sapiens_hsa046120.67965580
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67005426
80Taste transduction_Homo sapiens_hsa047420.65029428
81Wnt signaling pathway_Homo sapiens_hsa043100.60898936
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60829780
83Amphetamine addiction_Homo sapiens_hsa050310.60291218
84Asthma_Homo sapiens_hsa053100.60264818
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60158957
86Nitrogen metabolism_Homo sapiens_hsa009100.60013289
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.59615399
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59054777
89Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.59030831
90Metabolic pathways_Homo sapiens_hsa011000.58828547
91Axon guidance_Homo sapiens_hsa043600.55190829
92Hematopoietic cell lineage_Homo sapiens_hsa046400.53729513
93Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53101039
94GABAergic synapse_Homo sapiens_hsa047270.52280309
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51335978
96Starch and sucrose metabolism_Homo sapiens_hsa005000.51187648
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50231775
98Tryptophan metabolism_Homo sapiens_hsa003800.49406585
99Synaptic vesicle cycle_Homo sapiens_hsa047210.49269632
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48273118
101Linoleic acid metabolism_Homo sapiens_hsa005910.46106294
102Sulfur relay system_Homo sapiens_hsa041220.45372597
103Arginine and proline metabolism_Homo sapiens_hsa003300.45328034
104Epstein-Barr virus infection_Homo sapiens_hsa051690.44959698
105Morphine addiction_Homo sapiens_hsa050320.44891864
106Intestinal immune network for IgA production_Homo sapiens_hsa046720.44781350
107Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44034044
108Alcoholism_Homo sapiens_hsa050340.43622317
109TGF-beta signaling pathway_Homo sapiens_hsa043500.43256606
110Cysteine and methionine metabolism_Homo sapiens_hsa002700.42999873
111RNA transport_Homo sapiens_hsa030130.42925194
112Cocaine addiction_Homo sapiens_hsa050300.41721058
113Drug metabolism - other enzymes_Homo sapiens_hsa009830.40175160
114Cell cycle_Homo sapiens_hsa041100.39387871
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39358705
116Dopaminergic synapse_Homo sapiens_hsa047280.38582086
117Glutamatergic synapse_Homo sapiens_hsa047240.37891011
118Circadian entrainment_Homo sapiens_hsa047130.37663568
119Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36359840
120Gap junction_Homo sapiens_hsa045400.34063854
121Salivary secretion_Homo sapiens_hsa049700.34043999
122Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33417953
123Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33412283
124Other glycan degradation_Homo sapiens_hsa005110.32677405
125Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.32626307
126Adherens junction_Homo sapiens_hsa045200.31428957
127Notch signaling pathway_Homo sapiens_hsa043300.31308542
128Regulation of autophagy_Homo sapiens_hsa041400.31197142
129African trypanosomiasis_Homo sapiens_hsa051430.31026194
130Malaria_Homo sapiens_hsa051440.30885019
131Calcium signaling pathway_Homo sapiens_hsa040200.29969423
132Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.29795187
133ECM-receptor interaction_Homo sapiens_hsa045120.28707504
134Systemic lupus erythematosus_Homo sapiens_hsa053220.24951334
135Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.24881807
136Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24661617
137Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24417272
138Long-term depression_Homo sapiens_hsa047300.22690534
139Pertussis_Homo sapiens_hsa051330.21760989
140Renin secretion_Homo sapiens_hsa049240.21276974
141Circadian rhythm_Homo sapiens_hsa047100.20885489
142alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19280269
143N-Glycan biosynthesis_Homo sapiens_hsa005100.17391786
144NOD-like receptor signaling pathway_Homo sapiens_hsa046210.15138821
145Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.13288773
146Cholinergic synapse_Homo sapiens_hsa047250.12718454
147Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.11935765
148Ovarian steroidogenesis_Homo sapiens_hsa049130.10550890

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