CETN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains four EF-hand calcium binding domains, and is a member of the centrin protein family. Centrins are evolutionarily conserved proteins similar to the CDC31 protein of S. cerevisiae. Yeast CDC31 is located at the centrosome of interphase and mitotic cells, where it plays a fundamental role in centrosome duplication and separation. Multiple forms of the proteins similar to the yeast centrin have been identified in human and other mammalian cells, some of which have been shown to be associated with centrosome fractions. This protein appears to be one of the most abundant centrins associated with centrosome, which suggests a similar function to its yeast counterpart. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.35643857
2DNA deamination (GO:0045006)5.01102502
3CENP-A containing nucleosome assembly (GO:0034080)4.80990706
4chromatin remodeling at centromere (GO:0031055)4.63323128
5telomere maintenance via semi-conservative replication (GO:0032201)4.49622340
6proteasome assembly (GO:0043248)4.44548564
7establishment of protein localization to mitochondrial membrane (GO:0090151)4.33465315
8protein neddylation (GO:0045116)4.32696286
9telomere maintenance via recombination (GO:0000722)4.13475951
10kinetochore organization (GO:0051383)4.06533039
11DNA strand elongation involved in DNA replication (GO:0006271)4.03471464
12ribosomal small subunit biogenesis (GO:0042274)3.96367911
13DNA replication-independent nucleosome assembly (GO:0006336)3.94974780
14DNA replication-independent nucleosome organization (GO:0034724)3.94974780
15kinetochore assembly (GO:0051382)3.91763736
16mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.91736057
17DNA strand elongation (GO:0022616)3.90926115
18pseudouridine synthesis (GO:0001522)3.88566551
19viral transcription (GO:0019083)3.87662591
20translational termination (GO:0006415)3.84462726
21chaperone-mediated protein transport (GO:0072321)3.82696930
22mitotic recombination (GO:0006312)3.81864310
23DNA replication initiation (GO:0006270)3.78042543
24SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.76950245
25histone exchange (GO:0043486)3.75092818
26maturation of SSU-rRNA (GO:0030490)3.74817623
27negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.74612975
28deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.74260719
29cotranslational protein targeting to membrane (GO:0006613)3.71208200
30protein targeting to ER (GO:0045047)3.66888059
31respiratory electron transport chain (GO:0022904)3.53998705
32respiratory chain complex IV assembly (GO:0008535)3.53305889
33nucleotide-excision repair, DNA gap filling (GO:0006297)3.52621445
34protein localization to endoplasmic reticulum (GO:0070972)3.52066811
35telomere maintenance via telomere lengthening (GO:0010833)3.51271658
36cullin deneddylation (GO:0010388)3.50761136
37exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.50352182
38regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.49651907
39DNA replication checkpoint (GO:0000076)3.49444322
40positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.48055140
41electron transport chain (GO:0022900)3.47724632
42establishment of protein localization to endoplasmic reticulum (GO:0072599)3.45567670
43ribosomal large subunit biogenesis (GO:0042273)3.45532111
44sequestering of actin monomers (GO:0042989)3.45494690
45nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.43364142
46anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.43222495
47spliceosomal snRNP assembly (GO:0000387)3.43007850
482-deoxyribonucleotide biosynthetic process (GO:0009265)3.39730450
49deoxyribose phosphate biosynthetic process (GO:0046385)3.39730450
50translational elongation (GO:0006414)3.39492784
51deoxyribonucleotide biosynthetic process (GO:0009263)3.37368566
52termination of RNA polymerase III transcription (GO:0006386)3.35005716
53transcription elongation from RNA polymerase III promoter (GO:0006385)3.35005716
54establishment of integrated proviral latency (GO:0075713)3.34837260
557-methylguanosine RNA capping (GO:0009452)3.34352398
56RNA capping (GO:0036260)3.34352398
577-methylguanosine mRNA capping (GO:0006370)3.34269446
58negative regulation of ligase activity (GO:0051352)3.34223569
59negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.34223569
60DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.33489897
61GTP biosynthetic process (GO:0006183)3.33446051
62spliceosomal complex assembly (GO:0000245)3.32556201
63transcription-coupled nucleotide-excision repair (GO:0006283)3.31847062
64protein deneddylation (GO:0000338)3.30741777
65signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.28711344
66intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.28711344
67signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.27816832
68signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.27816832
69signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.27816832
70ribonucleoprotein complex biogenesis (GO:0022613)3.27657636
71regulation of cellular amino acid metabolic process (GO:0006521)3.23895501
72mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.23893641
73mitochondrial respiratory chain complex assembly (GO:0033108)3.19425001
74translation (GO:0006412)3.19155274
75intraciliary transport (GO:0042073)3.19000912
76RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.17245694
77tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.17245694
78viral mRNA export from host cell nucleus (GO:0046784)3.16490512
79signal transduction involved in DNA integrity checkpoint (GO:0072401)3.15024094
80signal transduction involved in DNA damage checkpoint (GO:0072422)3.15024094
81antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.14687210
82signal transduction involved in cell cycle checkpoint (GO:0072395)3.14265227
83mitochondrial respiratory chain complex I assembly (GO:0032981)3.14213525
84NADH dehydrogenase complex assembly (GO:0010257)3.14213525
85mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.14213525
86cellular protein complex disassembly (GO:0043624)3.13622557
87cytochrome complex assembly (GO:0017004)3.13616697
88translational initiation (GO:0006413)3.13520012
89protein complex biogenesis (GO:0070271)3.12151955
90DNA double-strand break processing (GO:0000729)3.11979592
91viral life cycle (GO:0019058)3.10866022
92deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.10679322
93nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.09951629
94guanosine-containing compound biosynthetic process (GO:1901070)3.09542067
95maturation of 5.8S rRNA (GO:0000460)3.07939796
96pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.07060685
97epithelial cilium movement (GO:0003351)3.05644043
98histone mRNA metabolic process (GO:0008334)3.02895370
99organelle disassembly (GO:1903008)3.01730722
100formation of translation preinitiation complex (GO:0001731)3.01538326
101cellular component biogenesis (GO:0044085)2.99659893
102centriole replication (GO:0007099)2.99551211
103pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.98603057
104pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.98232351
105positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.97936880
106rRNA processing (GO:0006364)2.97222698
107G1/S transition of mitotic cell cycle (GO:0000082)2.96050029
108cell cycle G1/S phase transition (GO:0044843)2.96050029
109ATP synthesis coupled proton transport (GO:0015986)2.95804903
110energy coupled proton transport, down electrochemical gradient (GO:0015985)2.95804903
111ribosome biogenesis (GO:0042254)2.93270211
112purine nucleobase biosynthetic process (GO:0009113)2.92471989
113DNA ligation (GO:0006266)2.91563456
114DNA damage response, detection of DNA damage (GO:0042769)2.90532790
115nonmotile primary cilium assembly (GO:0035058)2.87661158
116inner mitochondrial membrane organization (GO:0007007)2.86826705
117regulation of mitochondrial translation (GO:0070129)2.85367528
118protein localization to kinetochore (GO:0034501)2.83226229
119water-soluble vitamin biosynthetic process (GO:0042364)2.82654803
120microtubule depolymerization (GO:0007019)2.77760457
121regulation of meiosis I (GO:0060631)2.76564367
122mitotic metaphase plate congression (GO:0007080)2.72787695
123neuron fate determination (GO:0048664)2.70209545
124protein complex disassembly (GO:0043241)2.68399300
125protein K11-linked ubiquitination (GO:0070979)2.66901475
126protein-cofactor linkage (GO:0018065)2.66110411
127protein K6-linked ubiquitination (GO:0085020)2.65620235
128macromolecular complex disassembly (GO:0032984)2.64770535
129regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.62047264
130regulation of mitotic spindle checkpoint (GO:1903504)2.62047264
131spindle checkpoint (GO:0031577)2.60219410
132ATP biosynthetic process (GO:0006754)2.59640534
133negative regulation of transcription regulatory region DNA binding (GO:2000678)2.58455869
134metaphase plate congression (GO:0051310)2.57713106
135replication fork processing (GO:0031297)2.54780963
136somite development (GO:0061053)2.54591057
137mitotic spindle checkpoint (GO:0071174)2.52947342
138cilium movement (GO:0003341)2.52341077
139nuclear-transcribed mRNA catabolic process (GO:0000956)2.50975837
140negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.50460861
141negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.50460861
142negative regulation of mitotic sister chromatid segregation (GO:0033048)2.50460861
143negative regulation of mitotic sister chromatid separation (GO:2000816)2.50460861
144negative regulation of sister chromatid segregation (GO:0033046)2.50460861
145oxidative phosphorylation (GO:0006119)2.49021297
146protein localization to chromosome, centromeric region (GO:0071459)2.46967810

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.57738239
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.44727480
3* MYC_18555785_ChIP-Seq_MESCs_Mouse4.15783027
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.08626361
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.87676969
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.46283673
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.43963161
8* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.12042888
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.07881139
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.05085853
11ETS1_20019798_ChIP-Seq_JURKAT_Human3.02390889
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.97362326
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.90532640
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.89822046
15* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.84772600
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.79893203
17* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.79512372
18* VDR_23849224_ChIP-Seq_CD4+_Human2.74217208
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.69519061
20ELK1_19687146_ChIP-ChIP_HELA_Human2.60350969
21RBPJ_22232070_ChIP-Seq_NCS_Mouse2.49099879
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.45194310
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.44296430
24MYC_19079543_ChIP-ChIP_MESCs_Mouse2.37800388
25* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.32899622
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.27509892
27FOXP3_21729870_ChIP-Seq_TREG_Human2.25313572
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.24515337
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.22272576
30DCP1A_22483619_ChIP-Seq_HELA_Human2.21130029
31SRF_21415370_ChIP-Seq_HL-1_Mouse2.16217638
32NELFA_20434984_ChIP-Seq_ESCs_Mouse2.15454606
33* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.15225379
34VDR_22108803_ChIP-Seq_LS180_Human2.15203386
35* XRN2_22483619_ChIP-Seq_HELA_Human2.15074903
36ZNF274_21170338_ChIP-Seq_K562_Hela2.12144232
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.08475287
38* TTF2_22483619_ChIP-Seq_HELA_Human2.08007822
39IGF1R_20145208_ChIP-Seq_DFB_Human2.03337213
40HOXB4_20404135_ChIP-ChIP_EML_Mouse2.02279721
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.99112359
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.92475093
43GABP_19822575_ChIP-Seq_HepG2_Human1.91216831
44* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.88364692
45FOXM1_23109430_ChIP-Seq_U2OS_Human1.86373050
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85859667
47TAF15_26573619_Chip-Seq_HEK293_Human1.85009627
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.76704927
49* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.75337599
50E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.71838070
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.70361479
52GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.68791100
53EZH2_22144423_ChIP-Seq_EOC_Human1.68293170
54PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.66880791
55AR_21909140_ChIP-Seq_LNCAP_Human1.65001748
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61226307
57P300_19829295_ChIP-Seq_ESCs_Human1.59613757
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.59092683
59NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.58586419
60TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.57880164
61E2F1_21310950_ChIP-Seq_MCF-7_Human1.55402806
62* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.54972526
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54181577
64* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.53131367
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49690378
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.49563573
67MYC_18940864_ChIP-ChIP_HL60_Human1.45495686
68GBX2_23144817_ChIP-Seq_PC3_Human1.44580992
69* SOX2_16153702_ChIP-ChIP_HESCs_Human1.43136712
70ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39948521
71CBX2_27304074_Chip-Seq_ESCs_Mouse1.36686643
72ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.30494498
73BMI1_23680149_ChIP-Seq_NPCS_Mouse1.27960533
74* NANOG_16153702_ChIP-ChIP_HESCs_Human1.27896109
75SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27858403
76KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.27196682
77* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26103137
78FUS_26573619_Chip-Seq_HEK293_Human1.24809727
79IRF1_19129219_ChIP-ChIP_H3396_Human1.23281457
80* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.21985357
81RNF2_27304074_Chip-Seq_NSC_Mouse1.21754148
82CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.19545166
83ELK1_22589737_ChIP-Seq_MCF10A_Human1.19439336
84NOTCH1_21737748_ChIP-Seq_TLL_Human1.18951276
85* EWS_26573619_Chip-Seq_HEK293_Human1.13790051
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13080538
87EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11715131
88POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09320812
89TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08119511
90SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.08010927
91NANOG_18555785_ChIP-Seq_MESCs_Mouse1.06668391
92TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05430542
93GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04997980
94KDM5A_27292631_Chip-Seq_BREAST_Human1.04979557
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04863306
96CIITA_25753668_ChIP-Seq_RAJI_Human1.04538847
97ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03258498
98TP63_19390658_ChIP-ChIP_HaCaT_Human1.01996877
99GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01866350
100FLI1_27457419_Chip-Seq_LIVER_Mouse1.01824713
101IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.99967415
102* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99838229
103ER_23166858_ChIP-Seq_MCF-7_Human0.99653574
104* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99249160
105TP53_22573176_ChIP-Seq_HFKS_Human0.98890879
106E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98645467
107CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.97573756
108CBP_20019798_ChIP-Seq_JUKART_Human0.94844778
109IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94844778
110DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.92881068
111CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.92201119
112* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91594630
113PCGF2_27294783_Chip-Seq_ESCs_Mouse0.91552480
114CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91524155
115CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90928449
116HTT_18923047_ChIP-ChIP_STHdh_Human0.90414107
117SMAD3_21741376_ChIP-Seq_EPCs_Human0.89233809
118* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88974761
119KLF5_20875108_ChIP-Seq_MESCs_Mouse0.88446772
120SOX2_18555785_ChIP-Seq_MESCs_Mouse0.86619201
121PIAS1_25552417_ChIP-Seq_VCAP_Human0.85217060
122SPI1_23547873_ChIP-Seq_NB4_Human0.85163650
123AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.84395935
124KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.81162438
125* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.77534836
126* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.76796343
127SOX17_20123909_ChIP-Seq_XEN_Mouse0.75257739
128FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.74545197
129FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71551359
130POU5F1_16153702_ChIP-ChIP_HESCs_Human0.71495248
131PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.63912088
132TFEB_21752829_ChIP-Seq_HELA_Human0.60969298
133RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.60910489
134HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.58975742
135SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.58965672
136SALL1_21062744_ChIP-ChIP_HESCs_Human0.58472081
137KAP1_22055183_ChIP-Seq_ESCs_Mouse0.57549339

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.87825653
2MP0010094_abnormal_chromosome_stability3.87384289
3MP0008058_abnormal_DNA_repair3.77321145
4MP0004957_abnormal_blastocyst_morpholog3.43991056
5MP0008057_abnormal_DNA_replication3.22974318
6MP0009379_abnormal_foot_pigmentation3.05020678
7MP0003077_abnormal_cell_cycle2.93202110
8MP0003111_abnormal_nucleus_morphology2.91970230
9MP0006292_abnormal_olfactory_placode2.77884963
10MP0008877_abnormal_DNA_methylation2.50694298
11MP0008007_abnormal_cellular_replicative2.41331407
12MP0008932_abnormal_embryonic_tissue2.36873535
13MP0006072_abnormal_retinal_apoptosis2.29181750
14MP0002396_abnormal_hematopoietic_system2.20700752
15MP0001188_hyperpigmentation2.20260888
16MP0003786_premature_aging2.02235518
17MP0003123_paternal_imprinting2.01172739
18MP0009697_abnormal_copulation1.87993353
19MP0010030_abnormal_orbit_morphology1.85777064
20MP0002095_abnormal_skin_pigmentation1.80229251
21MP0002938_white_spotting1.80201297
22MP0003880_abnormal_central_pattern1.79635579
23MP0002837_dystrophic_cardiac_calcinosis1.71437144
24MP0003121_genomic_imprinting1.63730232
25MP0008789_abnormal_olfactory_epithelium1.62542363
26MP0002234_abnormal_pharynx_morphology1.62237355
27MP0006054_spinal_hemorrhage1.58557726
28MP0000778_abnormal_nervous_system1.55762124
29MP0002160_abnormal_reproductive_system1.55522259
30MP0002210_abnormal_sex_determination1.54562306
31MP0003718_maternal_effect1.48820875
32MP0001286_abnormal_eye_development1.48708765
33MP0002233_abnormal_nose_morphology1.45401754
34MP0005075_abnormal_melanosome_morpholog1.43749984
35MP0000015_abnormal_ear_pigmentation1.40564834
36MP0002102_abnormal_ear_morphology1.39998826
37MP0005253_abnormal_eye_physiology1.37933821
38MP0003136_yellow_coat_color1.37881199
39MP0005174_abnormal_tail_pigmentation1.37118923
40MP0004147_increased_porphyrin_level1.37010313
41MP0003119_abnormal_digestive_system1.35519470
42MP0001986_abnormal_taste_sensitivity1.34783312
43MP0003186_abnormal_redox_activity1.33636107
44MP0000490_abnormal_crypts_of1.32166801
45MP0005389_reproductive_system_phenotype1.32075295
46MP0002653_abnormal_ependyma_morphology1.30643940
47MP0002697_abnormal_eye_size1.29119876
48MP0003938_abnormal_ear_development1.28637826
49MP0001485_abnormal_pinna_reflex1.28331816
50MP0000049_abnormal_middle_ear1.27094180
51MP0003763_abnormal_thymus_physiology1.26645539
52MP0002163_abnormal_gland_morphology1.26339201
53MP0005551_abnormal_eye_electrophysiolog1.25746049
54MP0003195_calcinosis1.24315310
55MP0003011_delayed_dark_adaptation1.23480963
56MP0002638_abnormal_pupillary_reflex1.23364279
57MP0004808_abnormal_hematopoietic_stem1.22835166
58MP0000566_synostosis1.22492105
59MP0001145_abnormal_male_reproductive1.20838704
60MP0001929_abnormal_gametogenesis1.15944699
61MP0003315_abnormal_perineum_morphology1.14473881
62MP0000372_irregular_coat_pigmentation1.13508930
63MP0001919_abnormal_reproductive_system1.13484043
64MP0000350_abnormal_cell_proliferation1.12830189
65MP0003755_abnormal_palate_morphology1.11472988
66MP0000653_abnormal_sex_gland1.11212160
67MP0005391_vision/eye_phenotype1.10728404
68MP0004142_abnormal_muscle_tone1.10004213
69MP0005187_abnormal_penis_morphology1.08294848
70MP0002822_catalepsy1.07024269
71MP0000647_abnormal_sebaceous_gland1.05190180
72MP0001119_abnormal_female_reproductive1.05063256
73MP0003567_abnormal_fetal_cardiomyocyte1.04912856
74MP0002009_preneoplasia1.04419385
75MP0003787_abnormal_imprinting1.03613166
76MP0000313_abnormal_cell_death1.03188105
77MP0000026_abnormal_inner_ear1.03184136
78MP0006276_abnormal_autonomic_nervous1.01966998
79MP0002132_abnormal_respiratory_system1.01420040
80MP0003941_abnormal_skin_development1.00670325
81MP0004885_abnormal_endolymph1.00619980
82MP0005499_abnormal_olfactory_system1.00499886
83MP0005394_taste/olfaction_phenotype1.00499886
84MP0001835_abnormal_antigen_presentation0.99367247
85MP0003861_abnormal_nervous_system0.98936179
86MP0005195_abnormal_posterior_eye0.97921855
87MP0001905_abnormal_dopamine_level0.96994462
88MP0000631_abnormal_neuroendocrine_gland0.95867407
89MP0002752_abnormal_somatic_nervous0.93935390
90MP0002736_abnormal_nociception_after0.93918305
91MP0002019_abnormal_tumor_incidence0.93346822
92MP0004215_abnormal_myocardial_fiber0.93087587
93MP0001730_embryonic_growth_arrest0.92756309
94MP0005248_abnormal_Harderian_gland0.92540094
95MP0005409_darkened_coat_color0.90915954
96MP0002085_abnormal_embryonic_tissue0.90777799
97MP0001529_abnormal_vocalization0.89284865
98MP0009333_abnormal_splenocyte_physiolog0.89133017
99MP0001697_abnormal_embryo_size0.88538573
100MP0001293_anophthalmia0.88187749
101MP0002090_abnormal_vision0.87482630
102MP0000537_abnormal_urethra_morphology0.87327760
103MP0009250_abnormal_appendicular_skeleto0.87048019
104MP0001486_abnormal_startle_reflex0.86645985
105MP0002084_abnormal_developmental_patter0.85597914
106MP0003890_abnormal_embryonic-extraembry0.84968854
107MP0003122_maternal_imprinting0.84600570
108MP0002177_abnormal_outer_ear0.84030872
109MP0001324_abnormal_eye_pigmentation0.82327465
110MP0002557_abnormal_social/conspecific_i0.82029562
111MP0002751_abnormal_autonomic_nervous0.81912025
112MP0002184_abnormal_innervation0.81866941
113MP0006036_abnormal_mitochondrial_physio0.81511661
114MP0005408_hypopigmentation0.81278826
115MP0003385_abnormal_body_wall0.81026279
116MP0003698_abnormal_male_reproductive0.80939938
117MP0000681_abnormal_thyroid_gland0.80464096
118MP0003942_abnormal_urinary_system0.80438448
119MP0005645_abnormal_hypothalamus_physiol0.79959570
120MP0005671_abnormal_response_to0.79919825
121MP0009046_muscle_twitch0.79675731
122MP0005171_absent_coat_pigmentation0.79241477
123MP0002092_abnormal_eye_morphology0.78355401
124MP0002398_abnormal_bone_marrow0.78260202
125MP0005084_abnormal_gallbladder_morpholo0.76552439
126MP0000465_gastrointestinal_hemorrhage0.76292022
127MP0002277_abnormal_respiratory_mucosa0.76099747
128MP0003935_abnormal_craniofacial_develop0.74963078
129MP0000955_abnormal_spinal_cord0.74807041
130MP0002272_abnormal_nervous_system0.74412022
131MP0000613_abnormal_salivary_gland0.73278272
132MP0000703_abnormal_thymus_morphology0.71656756
133MP0001186_pigmentation_phenotype0.71543926
134MP0003937_abnormal_limbs/digits/tail_de0.69753201
135MP0006035_abnormal_mitochondrial_morpho0.69501510
136MP0004133_heterotaxia0.69129892
137MP0002080_prenatal_lethality0.68240016
138MP0002148_abnormal_hypersensitivity_rea0.68001740
139MP0003943_abnormal_hepatobiliary_system0.67820746
140MP0001984_abnormal_olfaction0.66885098
141MP0008995_early_reproductive_senescence0.66660347
142MP0001545_abnormal_hematopoietic_system0.66602751
143MP0005397_hematopoietic_system_phenotyp0.66602751
144MP0001346_abnormal_lacrimal_gland0.66444541
145MP0004782_abnormal_surfactant_physiolog0.64792709
146MP0010386_abnormal_urinary_bladder0.63384465
147MP0002282_abnormal_trachea_morphology0.62197985
148MP0002722_abnormal_immune_system0.61097910

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)4.26099311
2Abnormality of cells of the erythroid lineage (HP:0012130)4.12452141
3Acute necrotizing encephalopathy (HP:0006965)3.87249444
4Birth length less than 3rd percentile (HP:0003561)3.85115103
5Aplastic anemia (HP:0001915)3.84079028
6Reticulocytopenia (HP:0001896)3.73102894
7Abnormal mitochondria in muscle tissue (HP:0008316)3.53891324
8Mitochondrial inheritance (HP:0001427)3.52649148
9Type I transferrin isoform profile (HP:0003642)3.35497772
10Hepatocellular necrosis (HP:0001404)3.28502557
11Abnormality of the labia minora (HP:0012880)3.18588975
12Increased CSF lactate (HP:0002490)3.15052662
13Progressive macrocephaly (HP:0004481)3.12760371
14Pancreatic fibrosis (HP:0100732)3.06992248
15Nephronophthisis (HP:0000090)3.06657023
16Colon cancer (HP:0003003)3.02016069
17True hermaphroditism (HP:0010459)2.99809268
18Decreased activity of mitochondrial respiratory chain (HP:0008972)2.97064189
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.97064189
20Aplasia/Hypoplasia of the sacrum (HP:0008517)2.94594484
21Type 2 muscle fiber atrophy (HP:0003554)2.94001925
22Increased hepatocellular lipid droplets (HP:0006565)2.91787948
23Oral leukoplakia (HP:0002745)2.83258152
2411 pairs of ribs (HP:0000878)2.83121012
25Pancreatic cysts (HP:0001737)2.81139020
26Muscle fiber atrophy (HP:0100295)2.78703472
27Hepatic necrosis (HP:0002605)2.77747286
28Hyperglycinemia (HP:0002154)2.73837190
29Acute encephalopathy (HP:0006846)2.73106360
303-Methylglutaconic aciduria (HP:0003535)2.72489324
31Abnormality of the heme biosynthetic pathway (HP:0010472)2.67225243
32Cerebral edema (HP:0002181)2.65714976
33Septo-optic dysplasia (HP:0100842)2.62844194
34Chromsome breakage (HP:0040012)2.62270444
35Increased serum lactate (HP:0002151)2.58363538
36Meckel diverticulum (HP:0002245)2.57558854
37Breast hypoplasia (HP:0003187)2.56469056
38Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.55853575
39Pallor (HP:0000980)2.52102899
40Abnormality of the preputium (HP:0100587)2.51909211
41Microvesicular hepatic steatosis (HP:0001414)2.51322864
42Genital tract atresia (HP:0001827)2.49339381
43Abnormality of the ileum (HP:0001549)2.49136792
44Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.48170447
45Medial flaring of the eyebrow (HP:0010747)2.45208706
46Methylmalonic acidemia (HP:0002912)2.44810577
47Vaginal atresia (HP:0000148)2.44285618
48Abnormality of chromosome stability (HP:0003220)2.44144145
49Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.42322074
50Abnormality of alanine metabolism (HP:0010916)2.42322074
51Hyperalaninemia (HP:0003348)2.42322074
52Abnormal spermatogenesis (HP:0008669)2.41234460
53Macrocytic anemia (HP:0001972)2.39895841
54Exercise intolerance (HP:0003546)2.38731769
55Stenosis of the external auditory canal (HP:0000402)2.38668238
56Lipid accumulation in hepatocytes (HP:0006561)2.38568293
57Abnormal protein glycosylation (HP:0012346)2.32039519
58Abnormal glycosylation (HP:0012345)2.32039519
59Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.32039519
60Abnormal protein N-linked glycosylation (HP:0012347)2.32039519
61Abnormality of the renal medulla (HP:0100957)2.30859053
62Chromosomal breakage induced by crosslinking agents (HP:0003221)2.30844978
63Supernumerary spleens (HP:0009799)2.29373905
64Congenital, generalized hypertrichosis (HP:0004540)2.28699340
65Exertional dyspnea (HP:0002875)2.27778505
66Oligodactyly (hands) (HP:0001180)2.27735593
67Nephrogenic diabetes insipidus (HP:0009806)2.27711753
68Abnormal lung lobation (HP:0002101)2.27616101
69Aplasia/Hypoplasia of the tongue (HP:0010295)2.25162707
70Patellar aplasia (HP:0006443)2.24726975
71Premature graying of hair (HP:0002216)2.24640482
72Abnormality of midbrain morphology (HP:0002418)2.22505455
73Molar tooth sign on MRI (HP:0002419)2.22505455
74Sclerocornea (HP:0000647)2.22231623
75Reduced antithrombin III activity (HP:0001976)2.21213720
76Abnormal respiratory motile cilium morphology (HP:0005938)2.18657153
77Abnormal respiratory epithelium morphology (HP:0012253)2.18657153
78Degeneration of anterior horn cells (HP:0002398)2.18493969
79Abnormality of the anterior horn cell (HP:0006802)2.18493969
80Congenital primary aphakia (HP:0007707)2.17202224
81Anophthalmia (HP:0000528)2.13468806
82Aplasia/Hypoplasia of the patella (HP:0006498)2.12918867
83Postaxial foot polydactyly (HP:0001830)2.12828165
84Rough bone trabeculation (HP:0100670)2.12604519
85Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.10771660
86Microretrognathia (HP:0000308)2.10632678
87Renal Fanconi syndrome (HP:0001994)2.10277545
88Lactic acidosis (HP:0003128)2.06807449
89Hypothermia (HP:0002045)2.06663898
90Gait imbalance (HP:0002141)2.05547449
91Intestinal atresia (HP:0011100)2.05217626
92Aplasia/Hypoplasia of the uvula (HP:0010293)2.05151862
93Respiratory difficulties (HP:0002880)2.03287675
94Abnormality of renal resorption (HP:0011038)2.02518415
95Myelodysplasia (HP:0002863)2.02335006
96Postaxial hand polydactyly (HP:0001162)2.01669206
97Small intestinal stenosis (HP:0012848)1.98421234
98Duodenal stenosis (HP:0100867)1.98421234
99Absent thumb (HP:0009777)1.95924084
100Pendular nystagmus (HP:0012043)1.95869148
101Respiratory failure (HP:0002878)1.94661839
102Methylmalonic aciduria (HP:0012120)1.94065270
103Poor coordination (HP:0002370)1.92886759
104Poor head control (HP:0002421)1.91712227
105Optic nerve coloboma (HP:0000588)1.91062006
106Aplasia/hypoplasia of the uterus (HP:0008684)1.90330611
107Abnormality of serum amino acid levels (HP:0003112)1.90321886
108Abnormality of glycolysis (HP:0004366)1.89617232
109Increased serum pyruvate (HP:0003542)1.89617232
110Bone marrow hypocellularity (HP:0005528)1.88907845
111Increased intramyocellular lipid droplets (HP:0012240)1.88250112
112Preaxial hand polydactyly (HP:0001177)1.87156092
113Optic disc pallor (HP:0000543)1.86724298
114Pancytopenia (HP:0001876)1.86368710
115Irregular epiphyses (HP:0010582)1.86161002
116Triphalangeal thumb (HP:0001199)1.86150926
117Leukodystrophy (HP:0002415)1.84977442
118Volvulus (HP:0002580)1.83763028
119Absent septum pellucidum (HP:0001331)1.82902484
120Anencephaly (HP:0002323)1.82894340
121Sloping forehead (HP:0000340)1.82842415
122Nephroblastoma (Wilms tumor) (HP:0002667)1.82669295
123Abnormal ciliary motility (HP:0012262)1.81304625
124Abnormal respiratory motile cilium physiology (HP:0012261)1.80246236
125Severe visual impairment (HP:0001141)1.79662888
126Cortical dysplasia (HP:0002539)1.78550155
127Male pseudohermaphroditism (HP:0000037)1.76159218
128Cystic liver disease (HP:0006706)1.75899269
129Occipital encephalocele (HP:0002085)1.75729085
130Lethargy (HP:0001254)1.74996915
131Rhinitis (HP:0012384)1.74917144
132Gastrointestinal atresia (HP:0002589)1.74619011
133Abnormality of methionine metabolism (HP:0010901)1.74486644
134Hyperglycinuria (HP:0003108)1.73339067
135Absent/shortened dynein arms (HP:0200106)1.71668511
136Dynein arm defect of respiratory motile cilia (HP:0012255)1.71668511
137Bilateral microphthalmos (HP:0007633)1.71502581
138Short tibia (HP:0005736)1.71175375
139Optic nerve hypoplasia (HP:0000609)1.70808989
140Broad foot (HP:0001769)1.70790251
141Depressed nasal ridge (HP:0000457)1.69037573
142Abnormality of the duodenum (HP:0002246)1.67449018
143Abnormality of urine glucose concentration (HP:0011016)1.67059149
144Glycosuria (HP:0003076)1.67059149

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK163.69694557
2EIF2AK13.38945797
3CDC73.12662089
4WEE13.03837770
5SRPK12.88386369
6CCNB12.83942400
7BUB12.83681220
8VRK12.71616597
9WNK32.70480419
10VRK22.63117985
11BCKDK2.49104189
12PLK42.35872874
13MKNK12.34954890
14EIF2AK32.32845304
15MAP3K42.19485199
16NME22.10288476
17BRSK22.06139095
18MKNK22.02563580
19TRIM281.90698541
20MAP3K121.83702172
21CASK1.70549628
22TEC1.66395424
23CDK81.65103746
24ZAK1.60950583
25MST41.59172381
26PIM21.58619580
27ACVR1B1.52433514
28PBK1.52391650
29MAP4K21.51565656
30CDK191.51004442
31ERBB31.48843057
32DYRK31.48043293
33TLK11.46143713
34TAF11.40287181
35PLK11.35865623
36PLK31.34992693
37TESK11.34261646
38LIMK11.26631536
39BMPR1B1.21955832
40EIF2AK21.19545561
41AURKB1.19166800
42MUSK1.18244177
43CDK71.15529683
44NME11.12659020
45BRSK11.12076686
46TSSK61.11528364
47TNIK1.09871536
48ATR1.08170539
49AURKA1.04932109
50MYLK1.01534886
51MAPK151.00411294
52YES11.00380793
53MAP2K70.98461968
54BCR0.97870530
55PASK0.96917689
56NUAK10.95812152
57EPHB20.93374885
58CHEK20.92592302
59MARK10.91421445
60DYRK20.89772114
61NEK20.88949148
62NEK10.88903742
63BRAF0.87799469
64FRK0.87023279
65RPS6KB20.86033481
66CSNK1G30.85304713
67SIK30.84685569
68TTK0.83597825
69IRAK40.81046798
70TXK0.79726550
71FGFR20.79141317
72CSNK2A10.78209228
73STK390.76533641
74PLK20.76130640
75STK240.73217789
76ADRBK20.72788775
77BMPR20.71862653
78DAPK10.68582637
79PRKCG0.67535277
80WNK40.67462597
81MAPK130.66944922
82CDK30.66681854
83OXSR10.64674298
84EPHA40.64215155
85KDR0.63243478
86TAOK20.63069367
87STK30.62864997
88RPS6KA40.61973998
89TGFBR10.61774774
90UHMK10.59538109
91CSNK1G10.59466458
92MINK10.58974523
93MAPKAPK30.58396104
94CSNK2A20.57614144
95AKT30.57608218
96MAP2K40.57103159
97INSRR0.56431118
98NTRK20.56208398
99ARAF0.54060782
100RPS6KA50.53664888
101PAK30.52662836
102FGFR10.52461327
103TESK20.49248106
104ILK0.46998458
105PDK20.46522549
106PRKCE0.46200589
107ATM0.46032174
108CSNK1G20.43964202
109NLK0.43464580
110CSNK1E0.42452755
111PIM10.41832376
112BTK0.41391857
113CHEK10.40385470
114OBSCN0.37059270
115PINK10.36599842
116CSNK1A10.36407761
117KIT0.35861806
118IRAK10.35667469
119ERBB40.35045537
120MAPKAPK50.34143437
121CDK180.33745774
122MAP2K60.33588398
123CAMKK20.33585490
124CSNK1A1L0.32372836
125CDK140.32360141
126STK40.32335525
127PNCK0.31791336
128STK38L0.30352910
129RPS6KB10.29035049
130CDK10.28757437
131PAK10.28153990
132NEK60.28070760
133GRK10.27297533

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.53382068
2Ribosome_Homo sapiens_hsa030104.26596330
3Proteasome_Homo sapiens_hsa030504.21571955
4Mismatch repair_Homo sapiens_hsa034303.72978077
5RNA polymerase_Homo sapiens_hsa030203.26646601
6Spliceosome_Homo sapiens_hsa030403.08559070
7Homologous recombination_Homo sapiens_hsa034403.07772771
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.87696414
9Protein export_Homo sapiens_hsa030602.84001682
10Nucleotide excision repair_Homo sapiens_hsa034202.81940779
11Base excision repair_Homo sapiens_hsa034102.69988710
12Pyrimidine metabolism_Homo sapiens_hsa002402.51626482
13Basal transcription factors_Homo sapiens_hsa030222.35037946
14Oxidative phosphorylation_Homo sapiens_hsa001902.30198701
15RNA transport_Homo sapiens_hsa030132.29116729
16Parkinsons disease_Homo sapiens_hsa050122.28448297
17Fanconi anemia pathway_Homo sapiens_hsa034602.20807292
18Cell cycle_Homo sapiens_hsa041102.17435969
19RNA degradation_Homo sapiens_hsa030182.09223183
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.96120466
21Propanoate metabolism_Homo sapiens_hsa006401.94927666
22Huntingtons disease_Homo sapiens_hsa050161.92429722
23Non-homologous end-joining_Homo sapiens_hsa034501.82587333
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.68308566
25Purine metabolism_Homo sapiens_hsa002301.63355991
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.53435232
27Alzheimers disease_Homo sapiens_hsa050101.41381835
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.38135373
29Steroid biosynthesis_Homo sapiens_hsa001001.35888379
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33987381
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32458803
32Fatty acid elongation_Homo sapiens_hsa000621.24653007
33One carbon pool by folate_Homo sapiens_hsa006701.16996325
34Nicotine addiction_Homo sapiens_hsa050331.13704474
35mRNA surveillance pathway_Homo sapiens_hsa030151.13561348
36p53 signaling pathway_Homo sapiens_hsa041151.10122432
37SNARE interactions in vesicular transport_Homo sapiens_hsa041301.08956998
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.08060612
39Butanoate metabolism_Homo sapiens_hsa006501.07531225
40Pyruvate metabolism_Homo sapiens_hsa006201.06283938
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.05329334
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.05098315
43Epstein-Barr virus infection_Homo sapiens_hsa051690.97474052
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92804141
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91895028
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85651434
47Selenocompound metabolism_Homo sapiens_hsa004500.84970396
48Herpes simplex infection_Homo sapiens_hsa051680.84412197
49Maturity onset diabetes of the young_Homo sapiens_hsa049500.84254584
50Systemic lupus erythematosus_Homo sapiens_hsa053220.83796683
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.81050665
52Peroxisome_Homo sapiens_hsa041460.80209362
53Hedgehog signaling pathway_Homo sapiens_hsa043400.78763115
54N-Glycan biosynthesis_Homo sapiens_hsa005100.77755218
55Folate biosynthesis_Homo sapiens_hsa007900.68699912
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66526044
57Antigen processing and presentation_Homo sapiens_hsa046120.65652378
58Oocyte meiosis_Homo sapiens_hsa041140.64093438
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63488721
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63420951
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63060336
62Nitrogen metabolism_Homo sapiens_hsa009100.59008908
63Alcoholism_Homo sapiens_hsa050340.58488570
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57355152
65Arachidonic acid metabolism_Homo sapiens_hsa005900.57209764
66Collecting duct acid secretion_Homo sapiens_hsa049660.55352013
67Cardiac muscle contraction_Homo sapiens_hsa042600.55128619
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54063671
69Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53538591
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53324767
71Retinol metabolism_Homo sapiens_hsa008300.53133969
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51569894
73Allograft rejection_Homo sapiens_hsa053300.51510957
74Glutathione metabolism_Homo sapiens_hsa004800.51387619
75Tryptophan metabolism_Homo sapiens_hsa003800.50908172
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.50552485
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49806693
78Legionellosis_Homo sapiens_hsa051340.49431775
79Hippo signaling pathway_Homo sapiens_hsa043900.48275204
80Olfactory transduction_Homo sapiens_hsa047400.47603719
81Autoimmune thyroid disease_Homo sapiens_hsa053200.47369058
82Arginine and proline metabolism_Homo sapiens_hsa003300.46623233
83Chemical carcinogenesis_Homo sapiens_hsa052040.46070711
84Carbon metabolism_Homo sapiens_hsa012000.43986018
85Asthma_Homo sapiens_hsa053100.43983274
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43248629
87HTLV-I infection_Homo sapiens_hsa051660.43138879
88Primary immunodeficiency_Homo sapiens_hsa053400.42222932
89Taste transduction_Homo sapiens_hsa047420.41593305
90Caffeine metabolism_Homo sapiens_hsa002320.41273236
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40728130
92beta-Alanine metabolism_Homo sapiens_hsa004100.40299906
93Viral carcinogenesis_Homo sapiens_hsa052030.40175735
94Biosynthesis of amino acids_Homo sapiens_hsa012300.39851290
95Metabolic pathways_Homo sapiens_hsa011000.38911289
96Hematopoietic cell lineage_Homo sapiens_hsa046400.37417635
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35531767
98Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.35530687
99Intestinal immune network for IgA production_Homo sapiens_hsa046720.35365265
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34940717
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34690989
102GABAergic synapse_Homo sapiens_hsa047270.34032175
103Steroid hormone biosynthesis_Homo sapiens_hsa001400.33364348
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32708716
105Cocaine addiction_Homo sapiens_hsa050300.32593135
106Phototransduction_Homo sapiens_hsa047440.32325119
107Vitamin digestion and absorption_Homo sapiens_hsa049770.32122920
1082-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.30595709
109Graft-versus-host disease_Homo sapiens_hsa053320.30311316
110Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.28768227
111Type I diabetes mellitus_Homo sapiens_hsa049400.28381550
112Thyroid cancer_Homo sapiens_hsa052160.26998617
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.26840994
114Pentose phosphate pathway_Homo sapiens_hsa000300.26321886
115Measles_Homo sapiens_hsa051620.25805634
116Fatty acid metabolism_Homo sapiens_hsa012120.25632156
117Tyrosine metabolism_Homo sapiens_hsa003500.24708465
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24255101
119Vibrio cholerae infection_Homo sapiens_hsa051100.23915109
120Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.22151386
121Shigellosis_Homo sapiens_hsa051310.21587778
122Hepatitis B_Homo sapiens_hsa051610.21485799
123TGF-beta signaling pathway_Homo sapiens_hsa043500.21477525
124Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.21356245
125RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.19681057
126Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.19426276
127Regulation of autophagy_Homo sapiens_hsa041400.17288692
128Sulfur relay system_Homo sapiens_hsa041220.16517798
129Colorectal cancer_Homo sapiens_hsa052100.15790974
130Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.15405157
131Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.13808407
132NF-kappa B signaling pathway_Homo sapiens_hsa040640.13465840
133NOD-like receptor signaling pathway_Homo sapiens_hsa046210.13281574
134Wnt signaling pathway_Homo sapiens_hsa043100.12313018
135Serotonergic synapse_Homo sapiens_hsa047260.12126743
136Phagosome_Homo sapiens_hsa041450.12124527
137Influenza A_Homo sapiens_hsa051640.12009274
138Sphingolipid metabolism_Homo sapiens_hsa006000.11508439
139Cysteine and methionine metabolism_Homo sapiens_hsa002700.09650200
140Rheumatoid arthritis_Homo sapiens_hsa053230.09116103
141Apoptosis_Homo sapiens_hsa042100.08877769
142Pathways in cancer_Homo sapiens_hsa052000.08521419
143Other glycan degradation_Homo sapiens_hsa005110.07379216
144Linoleic acid metabolism_Homo sapiens_hsa005910.07138290
145Jak-STAT signaling pathway_Homo sapiens_hsa046300.05903545
146Viral myocarditis_Homo sapiens_hsa054160.05741734
147Basal cell carcinoma_Homo sapiens_hsa052170.05414385
148Drug metabolism - other enzymes_Homo sapiens_hsa009830.05169072

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