CETP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is found in plasma, where it is involved in the transfer of cholesteryl ester from high density lipoprotein (HDL) to other lipoproteins. Defects in this gene are a cause of hyperalphalipoproteinemia 1 (HALP1). Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1blood coagulation, intrinsic pathway (GO:0007597)6.49736234
2neutrophil activation involved in immune response (GO:0002283)6.27694988
3thrombin receptor signaling pathway (GO:0070493)6.07643489
4protein neddylation (GO:0045116)5.71024226
5leukocyte migration involved in inflammatory response (GO:0002523)5.44520488
6regulation of platelet activation (GO:0010543)5.21442639
7regulation of platelet aggregation (GO:0090330)4.95571038
8angiogenesis involved in wound healing (GO:0060055)4.74645601
9negative regulation of platelet activation (GO:0010544)4.66372865
10platelet aggregation (GO:0070527)4.64084366
11adenosine receptor signaling pathway (GO:0001973)4.45792249
12positive regulation of endothelial cell differentiation (GO:0045603)4.38332263
13regulation of integrin-mediated signaling pathway (GO:2001044)4.33298786
14negative regulation of homotypic cell-cell adhesion (GO:0034111)4.24828957
15negative regulation of thymocyte apoptotic process (GO:0070244)4.22182034
16negative regulation of norepinephrine secretion (GO:0010700)4.21033126
17platelet degranulation (GO:0002576)4.07814839
18erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.05110492
19L-phenylalanine catabolic process (GO:0006559)4.05110492
20positive regulation of blood coagulation (GO:0030194)4.04273429
21positive regulation of hemostasis (GO:1900048)4.04273429
22lipoxygenase pathway (GO:0019372)3.96732702
23neutrophil activation (GO:0042119)3.83645110
24regulation of integrin activation (GO:0033623)3.82848430
25positive regulation of receptor recycling (GO:0001921)3.71377149
26positive regulation of coagulation (GO:0050820)3.61876201
27endothelium development (GO:0003158)3.60565942
28negative regulation of blood coagulation (GO:0030195)3.58585725
29negative regulation of hemostasis (GO:1900047)3.58585725
30negative regulation of heart rate (GO:0010459)3.50523272
31platelet activation (GO:0030168)3.49248705
32positive regulation of mast cell activation (GO:0033005)3.49026682
33positive regulation of systemic arterial blood pressure (GO:0003084)3.48931486
34megakaryocyte development (GO:0035855)3.47969857
35regulation of lipoprotein metabolic process (GO:0050746)3.47851357
36L-phenylalanine metabolic process (GO:0006558)3.39329171
37erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.39329171
38regulation of hemostasis (GO:1900046)3.39150708
39regulation of blood coagulation (GO:0030193)3.39150708
40granulocyte activation (GO:0036230)3.38268523
41fibrinolysis (GO:0042730)3.37870621
42platelet formation (GO:0030220)3.36098523
43G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.35111681
44antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.34413827
45negative regulation of coagulation (GO:0050819)3.27585595
46positive regulation of macrophage differentiation (GO:0045651)3.25347557
47homotypic cell-cell adhesion (GO:0034109)3.24590927
48tyrosine metabolic process (GO:0006570)3.23747175
49purinergic nucleotide receptor signaling pathway (GO:0035590)3.18047491
50fusion of sperm to egg plasma membrane (GO:0007342)3.15000425
51regulation of endothelial cell differentiation (GO:0045601)3.12524352
52regulation of coagulation (GO:0050818)3.11158464
53extracellular fibril organization (GO:0043206)3.08195104
54* triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.03284009
55regulation of homotypic cell-cell adhesion (GO:0034110)3.02524204
56peptide catabolic process (GO:0043171)3.02222806
57positive regulation of cAMP-mediated signaling (GO:0043950)3.01864883
58positive regulation of Rho protein signal transduction (GO:0035025)2.96515615
59negative regulation of protein localization to cell surface (GO:2000009)2.95660133
60superoxide anion generation (GO:0042554)2.95572747
61regulation of Golgi to plasma membrane protein transport (GO:0042996)2.94833766
62beta-amyloid metabolic process (GO:0050435)2.93900628
63protein activation cascade (GO:0072376)2.93797205
64negative regulation of wound healing (GO:0061045)2.92499127
65Arp2/3 complex-mediated actin nucleation (GO:0034314)2.90462693
66purinergic receptor signaling pathway (GO:0035587)2.88849089
67regulation of norepinephrine secretion (GO:0014061)2.88702029
68pyrimidine nucleoside catabolic process (GO:0046135)2.86043069
69G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.84915006
70negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.83865431
71regulation of mast cell degranulation (GO:0043304)2.83213239
72negative regulation of neural precursor cell proliferation (GO:2000178)2.82584634
73regulation of receptor recycling (GO:0001919)2.81725233
74negative regulation of T cell apoptotic process (GO:0070233)2.79539513
75regulation of MHC class II biosynthetic process (GO:0045346)2.78889404
76negative regulation of calcium ion transport into cytosol (GO:0010523)2.76510726
77peptidyl-glutamic acid carboxylation (GO:0017187)2.74984269
78protein carboxylation (GO:0018214)2.74984269
79fibril organization (GO:0097435)2.74698928
80negative regulation of appetite (GO:0032099)2.73200277
81negative regulation of response to food (GO:0032096)2.73200277
82regulation of T-helper 1 cell differentiation (GO:0045625)2.72813420
83negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.71407800
84negative regulation of T-helper cell differentiation (GO:0045623)2.71407800
85leukocyte degranulation (GO:0043299)2.69961982
86regulation of mast cell activation involved in immune response (GO:0033006)2.69160094
87positive regulation of immunoglobulin mediated immune response (GO:0002891)2.68370726
88positive regulation of B cell mediated immunity (GO:0002714)2.68370726
89regulation of mast cell activation (GO:0033003)2.66134088
90negative regulation of focal adhesion assembly (GO:0051895)2.62719185
91negative regulation of cell junction assembly (GO:1901889)2.62719185
92negative regulation of adherens junction organization (GO:1903392)2.62719185
93positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.59861883
94negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.56133165
95positive regulation of wound healing (GO:0090303)2.56016341
96polyamine biosynthetic process (GO:0006596)2.55930538
97termination of signal transduction (GO:0023021)2.55400389
98regulation of cholesterol esterification (GO:0010872)2.55286058
99positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.54491545
100negative regulation of stress fiber assembly (GO:0051497)2.52757609

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human4.24007337
2LYL1_20887958_ChIP-Seq_HPC-7_Mouse3.88623626
3SCL_19346495_ChIP-Seq_HPC-7_Human3.72150425
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.49122986
5RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.43377196
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.03106752
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.87546074
8GATA1_19941826_ChIP-Seq_K562_Human2.86705633
9GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.77399941
10LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.77338999
11GATA2_21666600_ChIP-Seq_HMVEC_Human2.72020856
12GATA1_19941827_ChIP-Seq_MEL_Mouse2.60373719
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.59202706
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.57161261
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.41297596
16SPI1_23127762_ChIP-Seq_K562_Human2.35118901
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.34400480
18GATA2_20887958_ChIP-Seq_HPC-7_Mouse2.32858598
19TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.32773320
20SRY_22984422_ChIP-ChIP_TESTIS_Rat2.32124692
21GATA2_19941826_ChIP-Seq_K562_Human2.31743806
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.25005021
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.24738732
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.18313828
25IRF8_27001747_Chip-Seq_BMDM_Mouse2.17874798
26GATA1_22383799_ChIP-Seq_G1ME_Mouse2.17538159
27STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.12755133
28RUNX1_22412390_ChIP-Seq_EML_Mouse2.01300202
29ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.97302438
30GATA1_22025678_ChIP-Seq_K562_Human1.97246037
31EGR1_23403033_ChIP-Seq_LIVER_Mouse1.94969382
32MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.88592955
33RXR_22158963_ChIP-Seq_LIVER_Mouse1.77361605
34RUNX_20019798_ChIP-Seq_JUKART_Human1.75187203
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.72233320
36STAT4_19710469_ChIP-ChIP_TH1__Mouse1.61534969
37LXR_22158963_ChIP-Seq_LIVER_Mouse1.58141256
38BP1_19119308_ChIP-ChIP_Hs578T_Human1.55153959
39STAT6_21828071_ChIP-Seq_BEAS2B_Human1.54557882
40RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.53335305
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.52910687
42GATA2_22383799_ChIP-Seq_G1ME_Mouse1.48973502
43ELK4_26923725_Chip-Seq_MESODERM_Mouse1.47439653
44FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.47343003
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.46719155
46* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.44085280
47BRD4_27068464_Chip-Seq_AML-cells_Mouse1.43271023
48RARG_19884340_ChIP-ChIP_MEFs_Mouse1.42685417
49GATA1_19941827_ChIP-Seq_MEL86_Mouse1.35867731
50PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33354622
51PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31908030
52SPI1_23547873_ChIP-Seq_NB4_Human1.31751849
53* UTX_26944678_Chip-Seq_JUKART_Human1.29097635
54PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28835044
55HTT_18923047_ChIP-ChIP_STHdh_Human1.28833386
56PPARA_22158963_ChIP-Seq_LIVER_Mouse1.26943656
57PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.25174935
58VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.23634339
59* VDR_24763502_ChIP-Seq_THP-1_Human1.21067849
60STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.20954495
61SPI1_20517297_ChIP-Seq_HL60_Human1.19912699
62THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18305995
63NCOR1_26117541_ChIP-Seq_K562_Human1.17051254
64MAF_26560356_Chip-Seq_TH1_Human1.12153387
65* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07527050
66KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.06419312
67NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.05990013
68ELK3_25401928_ChIP-Seq_HUVEC_Human1.05932504
69MYB_26560356_Chip-Seq_TH2_Human1.05923111
70HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02010753
71HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.01193684
72STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.01089178
73TCF7_22412390_ChIP-Seq_EML_Mouse1.00203940
74MYB_26560356_Chip-Seq_TH1_Human0.99687566
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98309219
76GATA3_27048872_Chip-Seq_THYMUS_Human0.97077234
77ETS1_22383799_ChIP-Seq_G1ME_Mouse0.95250692
78CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94911910
79SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94637455
80STAT1_20625510_ChIP-Seq_HELA_Human0.94261908
81PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94020516
82CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93381888
83CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92465900
84TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.90034354
85VDR_24787735_ChIP-Seq_THP-1_Human0.89422165
86SALL4_22934838_ChIP-ChIP_CD34+_Human0.88273485
87PU_27001747_Chip-Seq_BMDM_Mouse0.87516944
88SOX2_20726797_ChIP-Seq_SW620_Human0.85847265
89GATA3_26560356_Chip-Seq_TH2_Human0.84609449
90FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.83667799
91PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.83252887
92NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.82203043
93NRF2_20460467_ChIP-Seq_MEFs_Mouse0.82203043
94JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81897358
95CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81584023
96CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80372282
97TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.80314438
98CTCF_27219007_Chip-Seq_ERYTHROID_Human0.79847229
99MYC_22102868_ChIP-Seq_BL_Human0.79707118
100LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.79291970

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology7.88821351
2MP0003724_increased_susceptibility_to4.11282292
3MP0008004_abnormal_stomach_pH3.84714098
4MP0003303_peritoneal_inflammation3.32920463
5MP0000465_gastrointestinal_hemorrhage3.24960490
6MP0001835_abnormal_antigen_presentation2.83735997
7MP0001879_abnormal_lymphatic_vessel2.68028434
8MP0005167_abnormal_blood-brain_barrier2.46035996
9MP0004510_myositis2.21587752
10MP0003566_abnormal_cell_adhesion2.16623099
11MP0005058_abnormal_lysosome_morphology2.15934907
12MP0000343_altered_response_to2.13359346
13MP0005671_abnormal_response_to2.11228145
14MP0010368_abnormal_lymphatic_system2.09946601
15MP0005000_abnormal_immune_tolerance1.93823415
16MP0000685_abnormal_immune_system1.92721385
17MP0003436_decreased_susceptibility_to1.88886034
18MP0002139_abnormal_hepatobiliary_system1.82264429
19MP0010155_abnormal_intestine_physiology1.81463802
20MP0003828_pulmonary_edema1.79428971
21MP0001800_abnormal_humoral_immune1.77841589
22MP0002148_abnormal_hypersensitivity_rea1.73356994
23MP0005083_abnormal_biliary_tract1.68406495
24MP0002132_abnormal_respiratory_system1.62883007
25MP0002398_abnormal_bone_marrow1.59929014
26MP0001790_abnormal_immune_system1.59139064
27MP0005387_immune_system_phenotype1.59139064
28MP0000230_abnormal_systemic_arterial1.58557210
29MP0005025_abnormal_response_to1.57503302
30MP0002723_abnormal_immune_serum1.57431527
31MP0010329_abnormal_lipoprotein_level1.57110410
32MP0003638_abnormal_response/metabolism_1.54365831
33MP0001851_eye_inflammation1.54298726
34MP0000249_abnormal_blood_vessel1.54196651
35MP0002452_abnormal_antigen_presenting1.49059991
36MP0002138_abnormal_hepatobiliary_system1.45161865
37MP0005085_abnormal_gallbladder_physiolo1.44544857
38MP0003300_gastrointestinal_ulcer1.43548383
39MP0002419_abnormal_innate_immunity1.42326333
40MP0009785_altered_susceptibility_to1.37757560
41MP0005084_abnormal_gallbladder_morpholo1.35740817
42MP0002420_abnormal_adaptive_immunity1.35719235
43MP0001533_abnormal_skeleton_physiology1.35108344
44MP0005365_abnormal_bile_salt1.33976791
45MP0001819_abnormal_immune_cell1.33869566
46MP0001545_abnormal_hematopoietic_system1.33331635
47MP0005397_hematopoietic_system_phenotyp1.33331635
48MP0009763_increased_sensitivity_to1.33105484
49MP0004947_skin_inflammation1.29326914
50MP0004130_abnormal_muscle_cell1.27802972
51MP0000689_abnormal_spleen_morphology1.26929146
52MP0009764_decreased_sensitivity_to1.25733297
53MP0009333_abnormal_splenocyte_physiolog1.24586716
54MP0002429_abnormal_blood_cell1.21638014
55MP0003879_abnormal_hair_cell1.20953510
56MP0001663_abnormal_digestive_system1.20295882
57MP0001845_abnormal_inflammatory_respons1.20013786
58MP0000858_altered_metastatic_potential1.18957452
59MP0000716_abnormal_immune_system1.18379974
60MP0008872_abnormal_physiological_respon1.15623774
61MP0004084_abnormal_cardiac_muscle1.14389566
62MP0003656_abnormal_erythrocyte_physiolo1.13448538
63MP0008874_decreased_physiological_sensi1.12700774
64MP0005410_abnormal_fertilization1.12355051
65MP0002722_abnormal_immune_system1.11680119
66MP0009697_abnormal_copulation1.10341813
67MP0003866_abnormal_defecation1.01916363
68MP0008775_abnormal_heart_ventricle1.01786732
69MP0008260_abnormal_autophagy1.00200267
70MP0009642_abnormal_blood_homeostasis0.99036145
71MP0006054_spinal_hemorrhage0.97972612
72MP0003011_delayed_dark_adaptation0.97256389
73MP0008875_abnormal_xenobiotic_pharmacok0.97096620
74MP0002736_abnormal_nociception_after0.96684272
75MP0003075_altered_response_to0.95937293
76MP0002998_abnormal_bone_remodeling0.95698135
77MP0002118_abnormal_lipid_homeostasis0.91938292
78MP0004036_abnormal_muscle_relaxation0.91051533
79MP0005360_urolithiasis0.89377351
80MP0005165_increased_susceptibility_to0.88652688
81MP0003763_abnormal_thymus_physiology0.85181105
82MP0009765_abnormal_xenobiotic_induced0.83313312
83MP0003191_abnormal_cellular_cholesterol0.82643501
84MP0009840_abnormal_foam_cell0.82344006
85MP0005535_abnormal_body_temperature0.79741668
86MP0004883_abnormal_blood_vessel0.79622495
87MP0003186_abnormal_redox_activity0.78643839
88MP0005023_abnormal_wound_healing0.77575392
89MP0005666_abnormal_adipose_tissue0.76664862
90MP0002405_respiratory_system_inflammati0.76265185
91MP0008469_abnormal_protein_level0.71344194
92MP0000703_abnormal_thymus_morphology0.71069122
93MP0004215_abnormal_myocardial_fiber0.70656679
94MP0004272_abnormal_basement_membrane0.69893041
95MP0002128_abnormal_blood_circulation0.69638739
96MP0003091_abnormal_cell_migration0.68767104
97MP0005381_digestive/alimentary_phenotyp0.68606973
98MP0003183_abnormal_peptide_metabolism0.68293682
99MP0003252_abnormal_bile_duct0.66418149
100MP0006036_abnormal_mitochondrial_physio0.66057844

Predicted human phenotypes

RankGene SetZ-score
1Menorrhagia (HP:0000132)9.47000182
2Increased mean platelet volume (HP:0011877)8.85169272
3Abnormal platelet volume (HP:0011876)8.50272059
4Purpura (HP:0000979)8.37453054
5Petechiae (HP:0000967)7.95218162
6Epistaxis (HP:0000421)7.14949595
7Gingival bleeding (HP:0000225)6.09494315
8Spontaneous hematomas (HP:0007420)5.27206767
9Impaired platelet aggregation (HP:0003540)4.99583891
10Abnormal platelet function (HP:0011869)4.99583891
11Conjunctival telangiectasia (HP:0000524)3.93665090
12Poikilocytosis (HP:0004447)3.92609814
13Abnormality of the common coagulation pathway (HP:0010990)3.88374394
14Joint hemorrhage (HP:0005261)3.86976220
15Acanthocytosis (HP:0001927)3.68303040
16Xanthomatosis (HP:0000991)3.48386835
17Abnormality of the vasculature of the conjunctiva (HP:0008054)3.47939918
18Dyschromatopsia (HP:0007641)3.34741147
19* Hyperlipoproteinemia (HP:0010980)3.33479187
20Abnormal pupillary function (HP:0007686)3.30839147
21Systemic lupus erythematosus (HP:0002725)3.26336998
22Abnormality of the heme biosynthetic pathway (HP:0010472)3.13416643
23Paralysis (HP:0003470)3.10689424
24Abnormality of macrophages (HP:0004311)3.05517961
25Bruising susceptibility (HP:0000978)3.03303753
26Joint swelling (HP:0001386)2.95658817
27Abnormality of lateral ventricle (HP:0030047)2.85464505
28Complement deficiency (HP:0004431)2.80054876
29Increased IgM level (HP:0003496)2.77886542
30Polycythemia (HP:0001901)2.71665734
31Eczematoid dermatitis (HP:0000976)2.66566557
32Hepatosplenomegaly (HP:0001433)2.61207580
33Abnormality of complement system (HP:0005339)2.61115114
34Abnormality of iron homeostasis (HP:0011031)2.53985755
35Obstructive lung disease (HP:0006536)2.52699108
36Chronic obstructive pulmonary disease (HP:0006510)2.52699108
37Spontaneous abortion (HP:0005268)2.44789381
38Recurrent gram-negative bacterial infections (HP:0005420)2.39650257
39Deep venous thrombosis (HP:0002625)2.39614504
40Increased density of long bones (HP:0006392)2.37582033
41Abnormality of aromatic amino acid family metabolism (HP:0004338)2.32683174
42Decreased central vision (HP:0007663)2.29234560
43Thrombophlebitis (HP:0004418)2.27757549
44Stomatitis (HP:0010280)2.27686801
45Hemorrhage of the eye (HP:0011885)2.27529317
46Encephalitis (HP:0002383)2.26201353
47Myocardial infarction (HP:0001658)2.25123738
48Glomerulonephritis (HP:0000099)2.22515000
49Abnormality of transition element cation homeostasis (HP:0011030)2.17939089
50Generalized aminoaciduria (HP:0002909)2.15381032
51Arterial thrombosis (HP:0004420)2.13505587
52Abnormality of monocarboxylic acid metabolism (HP:0010996)2.13466585
53Increased serum ferritin (HP:0003281)2.11851497
54Pulmonary embolism (HP:0002204)2.07701176
55Nausea (HP:0002018)2.05744271
56Upper limb muscle weakness (HP:0003484)2.04924632
57Abnormal auditory evoked potentials (HP:0006958)2.04298104
58Gastrointestinal stroma tumor (HP:0100723)2.03738193
59Vasculitis (HP:0002633)2.02339759
60Prolonged bleeding time (HP:0003010)10.0549386
61Meningitis (HP:0001287)1.98715653
62Prolonged partial thromboplastin time (HP:0003645)1.95618446
63IgA deficiency (HP:0002720)1.94260932
64Recurrent abscess formation (HP:0002722)1.92717437
65Hypertriglyceridemia (HP:0002155)1.88777230
66Mucosal telangiectasiae (HP:0100579)1.85109041
67Nephritis (HP:0000123)1.81961038
68Inflammation of the large intestine (HP:0002037)1.80334084
69Microcytic anemia (HP:0001935)1.80182213
70Abnormality of the prostate (HP:0008775)1.79709925
71Hypophosphatemic rickets (HP:0004912)1.78032959
72Episodic fever (HP:0001954)1.72184733
73Arthralgia (HP:0002829)1.71692856
74Dysostosis multiplex (HP:0000943)1.69748032
75Mitral stenosis (HP:0001718)1.69611446
76Cerebral hemorrhage (HP:0001342)1.69567747
77Autoimmune hemolytic anemia (HP:0001890)1.68048266
78Gastrointestinal inflammation (HP:0004386)1.64433857
79Vertigo (HP:0002321)1.63899796
80Dysautonomia (HP:0002459)1.63735536
81Basal ganglia calcification (HP:0002135)1.63591214
82Recurrent bacterial skin infections (HP:0005406)1.63124380
83Emphysema (HP:0002097)1.62258517
84Male infertility (HP:0003251)1.62044544
85Chest pain (HP:0100749)1.61905186
86Muscle fibrillation (HP:0010546)1.59695411
87Tinnitus (HP:0000360)1.57571845
88Thyroid-stimulating hormone excess (HP:0002925)1.56782106
89Recurrent sinusitis (HP:0011108)1.55389534
90Testicular neoplasm (HP:0010788)1.54324537
91Cellulitis (HP:0100658)1.51709009
92Cerebral ischemia (HP:0002637)1.51337957
93Distal lower limb amyotrophy (HP:0008944)1.51253673
94Agammaglobulinemia (HP:0004432)1.49736879
95Acute hepatic failure (HP:0006554)1.47381415
96Retrobulbar optic neuritis (HP:0100654)1.46817303
97Optic neuritis (HP:0100653)1.46817303
98Hypochromic microcytic anemia (HP:0004840)1.46297705
99Papillary thyroid carcinoma (HP:0002895)1.44428153
100Panhypogammaglobulinemia (HP:0003139)1.44378682

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.46270865
2MST44.03703207
3MYLK3.54801620
4BMX3.51740243
5BTK3.12704342
6TEC2.81069045
7PTK2B2.64504226
8CSF1R2.46853235
9SYK2.44942687
10EIF2AK12.29591740
11ZAP702.20285082
12BMPR22.08608945
13FES2.00855077
14ILK2.00574528
15GRK51.95705304
16GRK61.93428346
17BLK1.92538702
18FGR1.85599929
19MAP4K11.79253599
20TAOK31.78038016
21TIE11.77557224
22MAPKAPK31.63162258
23PIK3CG1.62266752
24HCK1.57594440
25MAP2K31.46352297
26LYN1.43204499
27DAPK31.38625386
28TNK21.35368915
29CSK1.34716625
30KDR1.31455263
31IKBKB1.30838484
32MATK1.17143572
33SIK31.05794923
34ITK1.05668055
35FGFR41.02275089
36EPHA30.99910405
37TAOK20.95137075
38TLK10.94534030
39PAK10.93414589
40MAP3K120.93311754
41ARAF0.92186703
42MAPK120.90316076
43RET0.89082449
44JAK10.88304083
45MARK30.86076720
46PDK10.83435928
47EPHB20.80893182
48IRAK40.80860375
49JAK30.79477379
50STK30.79425889
51PDPK10.75657239
52ACVR1B0.74466504
53NEK90.74316637
54FER0.73235316
55PIM20.72304272
56STK240.71799129
57LCK0.71185726
58TXK0.70087230
59MAP3K50.69479476
60IRAK10.69268140
61EPHB10.67300217
62JAK20.66739072
63PRKD10.63125080
64LMTK20.63078109
65MAP3K30.62086978
66TYK20.58647822
67FGFR30.58001590
68TBK10.57883922
69MAP3K110.57368678
70DAPK10.56777604
71ADRBK20.55569475
72PLK20.54208157
73TESK20.52385599
74ADRBK10.52144832
75PRKCQ0.50974052
76ERBB20.50889524
77DAPK20.50641394
78TAOK10.50178913
79PIM10.50164660
80PRPF4B0.49206194
81PKN10.48467027
82PRKACG0.48462516
83IKBKE0.48273134
84YES10.47880577
85DDR20.47520157
86PDGFRB0.46881273
87FYN0.46691563
88MAP3K10.45246518
89MAP2K10.44031928
90MAP3K130.43717855
91MAPK110.41147527
92MAP3K140.39445077
93IRAK30.38449330
94PRKCD0.37490206
95BMPR1B0.33765804
96HIPK20.33718020
97IGF1R0.33606693
98CDC42BPA0.33019289
99SRC0.30523094
100PRKG10.26715857

Predicted pathways (KEGG)

RankGene SetZ-score
1Platelet activation_Homo sapiens_hsa046114.37590218
2Complement and coagulation cascades_Homo sapiens_hsa046102.62770318
3Staphylococcus aureus infection_Homo sapiens_hsa051502.49824369
4Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.42626315
5Hematopoietic cell lineage_Homo sapiens_hsa046402.30282009
6Systemic lupus erythematosus_Homo sapiens_hsa053222.23075760
7SNARE interactions in vesicular transport_Homo sapiens_hsa041302.13728555
8Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.96035594
9Arachidonic acid metabolism_Homo sapiens_hsa005901.94303077
10Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.81965772
11Asthma_Homo sapiens_hsa053101.81905828
12Allograft rejection_Homo sapiens_hsa053301.80094190
13B cell receptor signaling pathway_Homo sapiens_hsa046621.78430599
14Chemokine signaling pathway_Homo sapiens_hsa040621.77103950
15Primary immunodeficiency_Homo sapiens_hsa053401.69206716
16Autoimmune thyroid disease_Homo sapiens_hsa053201.63959510
17ECM-receptor interaction_Homo sapiens_hsa045121.59881703
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.54714322
19Graft-versus-host disease_Homo sapiens_hsa053321.53319507
20Chemical carcinogenesis_Homo sapiens_hsa052041.40226784
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.39964929
22Caffeine metabolism_Homo sapiens_hsa002321.35161858
23Vascular smooth muscle contraction_Homo sapiens_hsa042701.28927096
24Malaria_Homo sapiens_hsa051441.26989403
25Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.26661284
26Alcoholism_Homo sapiens_hsa050341.21290278
27Glycerolipid metabolism_Homo sapiens_hsa005611.21070137
28Nitrogen metabolism_Homo sapiens_hsa009101.21014779
29Retinol metabolism_Homo sapiens_hsa008301.18858152
30Leukocyte transendothelial migration_Homo sapiens_hsa046701.16301059
31Tyrosine metabolism_Homo sapiens_hsa003501.14945058
32Linoleic acid metabolism_Homo sapiens_hsa005911.14592378
33Pentose and glucuronate interconversions_Homo sapiens_hsa000401.14247922
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.12888346
35Shigellosis_Homo sapiens_hsa051311.08311201
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.07577865
37Leishmaniasis_Homo sapiens_hsa051401.06611354
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.05619055
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.05448949
40Starch and sucrose metabolism_Homo sapiens_hsa005001.04252523
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.04134684
42Gap junction_Homo sapiens_hsa045401.03910837
43Serotonergic synapse_Homo sapiens_hsa047261.01059006
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.99855372
45Type I diabetes mellitus_Homo sapiens_hsa049400.98746019
46Osteoclast differentiation_Homo sapiens_hsa043800.98503590
47Phagosome_Homo sapiens_hsa041450.97247349
48PPAR signaling pathway_Homo sapiens_hsa033200.96024523
49Viral myocarditis_Homo sapiens_hsa054160.95260070
50Toll-like receptor signaling pathway_Homo sapiens_hsa046200.93776507
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.92360287
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90562523
53Endocytosis_Homo sapiens_hsa041440.89149071
54Collecting duct acid secretion_Homo sapiens_hsa049660.88791488
55Renin-angiotensin system_Homo sapiens_hsa046140.88182405
56Glycosaminoglycan degradation_Homo sapiens_hsa005310.86673794
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86177936
58alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81686423
59T cell receptor signaling pathway_Homo sapiens_hsa046600.81052294
60NF-kappa B signaling pathway_Homo sapiens_hsa040640.80322254
61Sulfur metabolism_Homo sapiens_hsa009200.78033398
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.77373235
63Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74564830
64Fatty acid degradation_Homo sapiens_hsa000710.72357275
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.72356881
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71797922
67Fat digestion and absorption_Homo sapiens_hsa049750.71067174
68Bile secretion_Homo sapiens_hsa049760.69681672
69Toxoplasmosis_Homo sapiens_hsa051450.67272023
70Focal adhesion_Homo sapiens_hsa045100.66203298
71Pertussis_Homo sapiens_hsa051330.65986662
72Glutathione metabolism_Homo sapiens_hsa004800.65911587
73Rheumatoid arthritis_Homo sapiens_hsa053230.65625568
74Pancreatic secretion_Homo sapiens_hsa049720.60626374
75Rap1 signaling pathway_Homo sapiens_hsa040150.60163833
76Tuberculosis_Homo sapiens_hsa051520.59126636
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57427809
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57194509
79Viral carcinogenesis_Homo sapiens_hsa052030.56235486
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.51842674
81Influenza A_Homo sapiens_hsa051640.51474822
82Pentose phosphate pathway_Homo sapiens_hsa000300.50554606
83Pancreatic cancer_Homo sapiens_hsa052120.50519122
84ABC transporters_Homo sapiens_hsa020100.50275833
85Antigen processing and presentation_Homo sapiens_hsa046120.48248808
86Prion diseases_Homo sapiens_hsa050200.48003127
87Fatty acid elongation_Homo sapiens_hsa000620.47235234
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46655834
89Amoebiasis_Homo sapiens_hsa051460.45900312
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.44450145
91Measles_Homo sapiens_hsa051620.43556518
92African trypanosomiasis_Homo sapiens_hsa051430.43314381
93Apoptosis_Homo sapiens_hsa042100.43033875
94Herpes simplex infection_Homo sapiens_hsa051680.42304919
95Ras signaling pathway_Homo sapiens_hsa040140.40369584
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.39506003
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38977450
98Choline metabolism in cancer_Homo sapiens_hsa052310.38755239
99Non-small cell lung cancer_Homo sapiens_hsa052230.36680015
100VEGF signaling pathway_Homo sapiens_hsa043700.35787642

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