CFAP157

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell wall macromolecule catabolic process (GO:0016998)9.77823456
2cell wall macromolecule metabolic process (GO:0044036)9.77823456
3acrosome reaction (GO:0007340)9.58225068
4multicellular organism reproduction (GO:0032504)9.56511209
5cilium movement (GO:0003341)9.47060316
6binding of sperm to zona pellucida (GO:0007339)9.27271994
7motile cilium assembly (GO:0044458)9.22116619
8cell-cell recognition (GO:0009988)8.97178905
9plasma membrane fusion (GO:0045026)8.71335532
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.16065509
11spermatid development (GO:0007286)8.09938519
12reproduction (GO:0000003)8.01118056
13regulation of cilium movement (GO:0003352)7.93798464
14primary alcohol catabolic process (GO:0034310)7.26951430
15synaptonemal complex organization (GO:0070193)6.91575101
16synaptonemal complex assembly (GO:0007130)6.85994928
17piRNA metabolic process (GO:0034587)6.70336816
18vitamin transmembrane transport (GO:0035461)6.70048942
19male meiosis (GO:0007140)6.69687680
20microtubule bundle formation (GO:0001578)6.50045419
21single fertilization (GO:0007338)6.45783923
22ethanol metabolic process (GO:0006067)6.06487517
23sperm capacitation (GO:0048240)5.83648131
24microtubule depolymerization (GO:0007019)5.82874890
25diterpenoid biosynthetic process (GO:0016102)5.65325594
26negative regulation of inclusion body assembly (GO:0090084)5.54988145
27ventricular system development (GO:0021591)5.49828674
28response to xenobiotic stimulus (GO:0009410)5.48042275
29tolerance induction (GO:0002507)5.46955705
30spermatogenesis (GO:0007283)5.43689514
31male gamete generation (GO:0048232)5.42135452
32male meiosis I (GO:0007141)5.36797601
33fertilization (GO:0009566)5.33830176
34microtubule severing (GO:0051013)5.16053148
35pyrimidine-containing compound transmembrane transport (GO:0072531)5.14293372
36spermatid nucleus differentiation (GO:0007289)5.04048186
37gamete generation (GO:0007276)4.98722942
38lung epithelium development (GO:0060428)4.96722999
39negative regulation of T cell differentiation in thymus (GO:0033085)4.90491585
40GTP biosynthetic process (GO:0006183)4.80484159
41establishment of apical/basal cell polarity (GO:0035089)4.80019020
42one-carbon compound transport (GO:0019755)4.71933971
43meiosis I (GO:0007127)4.65693227
44chromosome organization involved in meiosis (GO:0070192)4.65249822
45regulation of inclusion body assembly (GO:0090083)4.62950915
46cellular process involved in reproduction in multicellular organism (GO:0022412)4.57793268
47regulation of microtubule-based movement (GO:0060632)4.56592136
48monoubiquitinated protein deubiquitination (GO:0035520)4.53753888
49regulation of interleukin-5 production (GO:0032674)4.51915975
50nucleoside diphosphate phosphorylation (GO:0006165)4.48726219
51glomerular epithelial cell development (GO:0072310)4.45609286
52meiotic nuclear division (GO:0007126)4.44418623
53UTP biosynthetic process (GO:0006228)4.44248489
54germ cell development (GO:0007281)4.43599603
55regulation of germinal center formation (GO:0002634)4.40268075
56negative regulation of B cell mediated immunity (GO:0002713)4.39402069
57negative regulation of immunoglobulin mediated immune response (GO:0002890)4.39402069
58ethanol oxidation (GO:0006069)4.36200977
59cell projection assembly (GO:0030031)4.31669947
60calcium ion-dependent exocytosis (GO:0017156)4.24324538
61organic cation transport (GO:0015695)4.19885000
62cell recognition (GO:0008037)4.19674839
63DNA methylation involved in gamete generation (GO:0043046)4.19424972
64protein polyglutamylation (GO:0018095)4.18615719
65axoneme assembly (GO:0035082)4.17678881
66guanosine-containing compound biosynthetic process (GO:1901070)4.16759150
67establishment of monopolar cell polarity (GO:0061162)4.16044793
68establishment or maintenance of monopolar cell polarity (GO:0061339)4.16044793
69negative regulation of humoral immune response (GO:0002921)4.07952904
70regulation of interleukin-13 production (GO:0032656)3.96795057
71UTP metabolic process (GO:0046051)3.94241855
72terpenoid biosynthetic process (GO:0016114)3.92104593
73multicellular organismal reproductive process (GO:0048609)3.91464225
74retinoic acid metabolic process (GO:0042573)3.91455292
75positive regulation of tolerance induction (GO:0002645)3.86771983
76seminiferous tubule development (GO:0072520)3.81209349
77lateral ventricle development (GO:0021670)3.79827624
78cytoplasmic microtubule organization (GO:0031122)3.77431071
79negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.77330272
80exogenous drug catabolic process (GO:0042738)3.77099983
81left/right pattern formation (GO:0060972)3.66951736
82chaperone-mediated protein complex assembly (GO:0051131)3.61836666
83meiotic cell cycle (GO:0051321)3.52738357
84establishment of planar polarity (GO:0001736)3.51815022
85establishment of tissue polarity (GO:0007164)3.51815022
86chromosome condensation (GO:0030261)3.49225621
87CTP biosynthetic process (GO:0006241)3.44848026
88CTP metabolic process (GO:0046036)3.44848026
89single strand break repair (GO:0000012)3.38674496
90DNA packaging (GO:0006323)3.37554108
91glycerol ether metabolic process (GO:0006662)3.36075116
92positive regulation of macrophage activation (GO:0043032)3.34478794
93primary alcohol metabolic process (GO:0034308)3.31602316
94pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.30654012
95cilium organization (GO:0044782)3.29658112
96cilium morphogenesis (GO:0060271)3.28509863
97pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.27317610
98protein localization to cilium (GO:0061512)3.26943389
99determination of left/right symmetry (GO:0007368)3.22206251
100intraciliary transport (GO:0042073)3.20498058
101retinol metabolic process (GO:0042572)3.20004183
102O-glycan processing (GO:0016266)3.19333349
103microtubule-based movement (GO:0007018)3.18185881
104glutathione derivative biosynthetic process (GO:1901687)3.17278432
105glutathione derivative metabolic process (GO:1901685)3.17278432
106lateral sprouting from an epithelium (GO:0060601)3.16028854
107cilium assembly (GO:0042384)3.14322226
108positive regulation of smoothened signaling pathway (GO:0045880)3.11451724
109multicellular organismal development (GO:0007275)3.10299228
110meiotic cell cycle process (GO:1903046)3.09380846
111interferon-gamma secretion (GO:0072643)3.07374982
112determination of bilateral symmetry (GO:0009855)3.06935967
113ether metabolic process (GO:0018904)3.05896014
114drug catabolic process (GO:0042737)3.00396720
115specification of symmetry (GO:0009799)2.99993051
116hydrogen peroxide biosynthetic process (GO:0050665)2.98547499
117pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.97120814
118cellular component assembly involved in morphogenesis (GO:0010927)2.94095668
119nucleus organization (GO:0006997)2.93773233
120regulation of spindle checkpoint (GO:0090231)2.92643495
121aldehyde catabolic process (GO:0046185)2.92337628
122pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.91973281
123genitalia morphogenesis (GO:0035112)2.89930257
124protein refolding (GO:0042026)2.85102290
125microtubule polymerization or depolymerization (GO:0031109)2.84676809
126regulation of centriole replication (GO:0046599)2.82311502
127regulation of tolerance induction (GO:0002643)2.79891667
128regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.79115795
129centriole assembly (GO:0098534)2.78910517
130centriole replication (GO:0007099)2.78038245
131smoothened signaling pathway (GO:0007224)2.77358988
132microtubule-based process (GO:0007017)2.75927870
133regulation of microtubule depolymerization (GO:0031114)2.74204309
134protein K11-linked deubiquitination (GO:0035871)2.70450961
135phosphatidylcholine biosynthetic process (GO:0006656)2.68880423
136multicellular organismal water homeostasis (GO:0050891)2.68686411
137carnitine metabolic process (GO:0009437)2.67083149
138cellular response to arsenic-containing substance (GO:0071243)2.66904953
139protein localization to chromosome, centromeric region (GO:0071459)2.65388122
140alditol metabolic process (GO:0019400)2.65360592
141regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.65109695
142nucleotide phosphorylation (GO:0046939)2.63795429
143reactive oxygen species biosynthetic process (GO:1903409)2.62557500
144organelle assembly (GO:0070925)2.62294879
145calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.58939938
146apical protein localization (GO:0045176)2.58935453
147sexual reproduction (GO:0019953)2.57242020
148phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.55532315
149regulation of autophagic vacuole assembly (GO:2000785)2.53704941
150polyamine biosynthetic process (GO:0006596)2.53056385
151left/right axis specification (GO:0070986)2.52399960
152excretion (GO:0007588)2.52046828
153blastocyst development (GO:0001824)2.50944758
154hydrogen peroxide catabolic process (GO:0042744)2.49557964
155gene silencing by RNA (GO:0031047)2.48544748
156heart looping (GO:0001947)2.48426859
157phosphatidylethanolamine biosynthetic process (GO:0006646)2.48165816
158oligosaccharide biosynthetic process (GO:0009312)2.46160174
159dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.44949909
160histone exchange (GO:0043486)2.44599764
161retinal rod cell development (GO:0046548)2.42849203
162iron ion import (GO:0097286)2.41683659
163progesterone metabolic process (GO:0042448)2.37243729
164protein O-linked glycosylation (GO:0006493)2.33479013
165water homeostasis (GO:0030104)2.30759820
166hypotonic response (GO:0006971)2.28612039
167nonmotile primary cilium assembly (GO:0035058)2.27187648
168cilium or flagellum-dependent cell motility (GO:0001539)11.7025192
169axonemal dynein complex assembly (GO:0070286)11.6588732
170fusion of sperm to egg plasma membrane (GO:0007342)11.6029692
171sperm motility (GO:0030317)11.0909550
172acrosome assembly (GO:0001675)10.2970347
173epithelial cilium movement (GO:0003351)10.0338964
174sperm-egg recognition (GO:0035036)10.0159975

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.09745458
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.93778684
3DROSHA_22980978_ChIP-Seq_HELA_Human3.50910629
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.49640474
5FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.24537579
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.11844343
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.55578358
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.54856059
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.53189148
10CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.48124561
11ESR1_20079471_ChIP-ChIP_T-47D_Human2.12323207
12KAP1_22055183_ChIP-Seq_ESCs_Mouse2.03276212
13ESR1_21235772_ChIP-Seq_MCF-7_Human2.01648961
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.3084938
15AHR_22903824_ChIP-Seq_MCF-7_Human1.99933517
16RBPJ_22232070_ChIP-Seq_NCS_Mouse1.92960055
17RUNX1_27514584_Chip-Seq_MCF-7_Human1.91049631
18TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.88317630
19EZH2_22144423_ChIP-Seq_EOC_Human1.87682995
20PCGF2_27294783_Chip-Seq_NPCs_Mouse1.87216496
21ESR2_21235772_ChIP-Seq_MCF-7_Human1.84899048
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.84799679
23KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.84300039
24STAT1_20625510_ChIP-Seq_HELA_Human1.83324085
25SMC4_20622854_ChIP-Seq_HELA_Human1.82242457
26FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.74242053
27STAT6_21828071_ChIP-Seq_BEAS2B_Human1.71112679
28TDRD3_21172665_ChIP-Seq_MCF-7_Human1.70612254
29GATA1_26923725_Chip-Seq_HPCs_Mouse1.69590916
30CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.69422346
31ZNF274_21170338_ChIP-Seq_K562_Hela1.68538795
32ARNT_22903824_ChIP-Seq_MCF-7_Human1.65507404
33GATA3_21867929_ChIP-Seq_CD8_Mouse1.65429627
34PIAS1_25552417_ChIP-Seq_VCAP_Human1.65080030
35SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.64092256
36SOX2_27498859_Chip-Seq_STOMACH_Mouse1.61430983
37STAT1_17558387_ChIP-Seq_HELA_Human1.59956044
38AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.58352750
39TP63_23658742_ChIP-Seq_EP156T_Human1.57586259
40TP63_22573176_ChIP-Seq_HFKS_Human1.54804719
41VDR_22108803_ChIP-Seq_LS180_Human1.54099665
42ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.53248981
43FOXM1_26456572_ChIP-Seq_MCF-7_Human1.52533596
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.51859805
45CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.51553182
46P63_26484246_Chip-Seq_KERATINOCYTES_Human1.51541837
47NFE2_27457419_Chip-Seq_LIVER_Mouse1.51466236
48WDR5_24793694_ChIP-Seq_LNCAP_Human1.50909375
49FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.50249018
50KLF5_25053715_ChIP-Seq_YYC3_Human1.49913615
51EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.48464156
52TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.47095044
53GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.47025121
54SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45753323
55RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.45657017
56PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.44610916
57FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43706122
58SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.42880681
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41874897
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40374500
61NR3C1_21868756_ChIP-Seq_MCF10A_Human1.36550134
62ETV1_20927104_ChIP-Seq_GIST48_Human1.36493780
63ELK4_26923725_Chip-Seq_MESODERM_Mouse1.33434824
64TP53_18474530_ChIP-ChIP_U2OS_Human1.33313870
65CTNNB1_20460455_ChIP-Seq_HCT116_Human1.32806912
66SOX9_24532713_ChIP-Seq_HFSC_Mouse1.32254883
67CDX2_20551321_ChIP-Seq_CACO-2_Human1.30572302
68FOXA1_25552417_ChIP-Seq_VCAP_Human1.30413033
69GATA3_21867929_ChIP-Seq_TH1_Mouse1.28714936
70SOX2_20726797_ChIP-Seq_SW620_Human1.28713440
71EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28488781
72CTCF_27219007_Chip-Seq_Bcells_Human1.28109863
73P68_20966046_ChIP-Seq_HELA_Human1.28069155
74YY1_22570637_ChIP-Seq_MALME-3M_Human1.27827586
75LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.26917086
76CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25994544
77STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.25951596
78GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25671149
79FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.25620629
80PHF8_20622853_ChIP-Seq_HELA_Human1.24188288
81PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.23620319
82SOX2_22085726_ChIP-Seq_NPCs_Mouse1.23316372
83KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22558689
84SMRT_27268052_Chip-Seq_Bcells_Human1.22218075
85SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22083703
86HNFA_21074721_ChIP-Seq_CACO-2_Human1.21895530
87TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.21749911
88P53_21459846_ChIP-Seq_SAOS-2_Human1.21172587
89CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.20810797
90GATA1_19941826_ChIP-Seq_K562_Human1.19959645
91SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.19796063
92TAL1_26923725_Chip-Seq_HPCs_Mouse1.18296599
93RBPJ_21746931_ChIP-Seq_IB4_Human1.14009723
94ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.13246126
95GATA4_25053715_ChIP-Seq_YYC3_Human1.12604068
96TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12467697
97FOXM1_23109430_ChIP-Seq_U2OS_Human1.12320981
98RAD21_21589869_ChIP-Seq_MESCs_Mouse1.12266791
99FLI1_21867929_ChIP-Seq_CD8_Mouse1.11874097
100ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09029347
101FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.08977691
102EZH2_27294783_Chip-Seq_ESCs_Mouse1.08888680
103CREB1_26743006_Chip-Seq_LNCaP_Human1.08888267
104CRX_20693478_ChIP-Seq_RETINA_Mouse1.08065839
105SPI1_26923725_Chip-Seq_HPCs_Mouse1.06988590
106TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06400346
107CBX2_27304074_Chip-Seq_ESCs_Mouse1.06275032
108RACK7_27058665_Chip-Seq_MCF-7_Human1.05764032
109GATA6_21074721_ChIP-Seq_CACO-2_Human1.04561332
110PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.04399485
111IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04286224
112CBP_20019798_ChIP-Seq_JUKART_Human1.04286224
113GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.03994382
114GATA3_24758297_ChIP-Seq_MCF-7_Human1.03967632
115CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03950572
116ERG_20517297_ChIP-Seq_VCAP_Human1.03619408
117P300_27268052_Chip-Seq_Bcells_Human1.03249786
118TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02977397
119FOXO3_23340844_ChIP-Seq_DLD1_Human1.02797603
120PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01907710
121SMAD3_21741376_ChIP-Seq_HESCs_Human1.01311560
122EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01241803
123CBX2_22325352_ChIP-Seq_293T-Rex_Human1.00763426
124OCT4_18555785_Chip-Seq_ESCs_Mouse0.98842218
125PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98595063
126PPAR_26484153_Chip-Seq_NCI-H1993_Human0.98147606
127HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97844912
128LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97139690
129CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96969360
130NFYA_21822215_ChIP-Seq_K562_Human0.95814707
131FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.94743186
132RARA_24833708_ChIP-Seq_LIVER_Mouse0.94625319
133CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94039012
134FOXA2_19822575_ChIP-Seq_HepG2_Human0.93997675
135PHF8_20622854_ChIP-Seq_HELA_Human0.93964022
136SOX2_21211035_ChIP-Seq_LN229_Human0.93884930
137OCT4_21477851_ChIP-Seq_ESCs_Mouse0.93875214
138RUNX1_26923725_Chip-Seq_HPCs_Mouse0.93781349
139VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.93721079
140FLI1_21867929_ChIP-Seq_TH2_Mouse0.93553325
141ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93232883
142CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93137183
143GF1_26923725_Chip-Seq_HPCs_Mouse0.93099675
144RNF2_27304074_Chip-Seq_NSC_Mouse0.93080491
145P53_22387025_ChIP-Seq_ESCs_Mouse0.92557582
146TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92392900
147ESRRB_18555785_Chip-Seq_ESCs_Mouse0.92225024
148NANOG_18555785_Chip-Seq_ESCs_Mouse0.91367301
149FOXA1_25329375_ChIP-Seq_VCAP_Human0.90819139
150FOXA1_27270436_Chip-Seq_PROSTATE_Human0.90819139
151RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90798257
152SRY_22984422_ChIP-ChIP_TESTIS_Rat0.90045029
153SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.89969606
154NANOG_20526341_ChIP-Seq_ESCs_Human0.89558136
155CEBPB_22108803_ChIP-Seq_LS180_Human0.89093156
156BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87751818
157KDM2B_26808549_Chip-Seq_REH_Human0.87689532
158KLF4_18555785_Chip-Seq_ESCs_Mouse0.87463092
159TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.86629419
160EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.86512573
161SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86374680
162RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.85819510
163TBL1_22424771_ChIP-Seq_293T_Human0.85735866
164CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.85281826
165EZH2_27294783_Chip-Seq_NPCs_Mouse0.85269230
166MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84953235
167JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84546703
168CTCF_20526341_ChIP-Seq_ESCs_Human0.84354626
169TET1_21451524_ChIP-Seq_MESCs_Mouse0.83528705
170SMAD4_21741376_ChIP-Seq_EPCs_Human0.83260104
171CMYC_18555785_Chip-Seq_ESCs_Mouse0.82072512
172NFYB_21822215_ChIP-Seq_K562_Human0.80037418
173ELF1_20517297_ChIP-Seq_JURKAT_Human0.79963509
174SOX2_18555785_Chip-Seq_ESCs_Mouse0.79614556
175E2F1_20622854_ChIP-Seq_HELA_Human0.79444342
176EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.78595508
177PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.78372846

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok6.97349927
2MP0003698_abnormal_male_reproductive5.25236906
3MP0001929_abnormal_gametogenesis4.90032542
4MP0009780_abnormal_chondrocyte_physiolo4.06881906
5MP0002277_abnormal_respiratory_mucosa3.91625580
6MP0004043_abnormal_pH_regulation3.83909631
7MP0008877_abnormal_DNA_methylation3.57186153
8MP0002210_abnormal_sex_determination3.38576801
9MP0008789_abnormal_olfactory_epithelium3.15083840
10MP0005623_abnormal_meninges_morphology2.99999599
11MP0002161_abnormal_fertility/fecundity2.92969308
12MP0001145_abnormal_male_reproductive2.85252767
13MP0002653_abnormal_ependyma_morphology2.67977541
14MP0000653_abnormal_sex_gland2.49210136
15MP0000566_synostosis2.48955302
16MP0000383_abnormal_hair_follicle2.37794405
17MP0001984_abnormal_olfaction2.29771671
18MP0002160_abnormal_reproductive_system2.26199856
19MP0003693_abnormal_embryo_hatching2.23087685
20MP0005377_hearing/vestibular/ear_phenot2.10279106
21MP0003878_abnormal_ear_physiology2.10279106
22MP0005083_abnormal_biliary_tract2.09881700
23MP0005410_abnormal_fertilization13.5161050
24MP0010678_abnormal_skin_adnexa1.97506207
25MP0005394_taste/olfaction_phenotype1.96713371
26MP0005499_abnormal_olfactory_system1.96713371
27MP0000678_abnormal_parathyroid_gland1.87610641
28MP0002168_other_aberrant_phenotype1.87104575
29MP0008058_abnormal_DNA_repair1.80964541
30MP0005670_abnormal_white_adipose1.77633536
31MP0003656_abnormal_erythrocyte_physiolo1.74417356
32MP0002909_abnormal_adrenal_gland1.60645423
33MP0003111_abnormal_nucleus_morphology1.60592475
34MP0010030_abnormal_orbit_morphology1.59546306
35MP0010094_abnormal_chromosome_stability1.50625641
36MP0002876_abnormal_thyroid_physiology1.49916510
37MP0002249_abnormal_larynx_morphology1.48562852
38MP0001346_abnormal_lacrimal_gland1.48503406
39MP0010307_abnormal_tumor_latency1.46692063
40MP0002734_abnormal_mechanical_nocicepti1.34650694
41MP0003718_maternal_effect1.32499444
42MP0005257_abnormal_intraocular_pressure1.28507402
43MP0002796_impaired_skin_barrier1.27258453
44MP0005636_abnormal_mineral_homeostasis1.26263955
45MP0009379_abnormal_foot_pigmentation1.25870065
46MP0002282_abnormal_trachea_morphology1.24853418
47MP0005389_reproductive_system_phenotype1.23072644
48MP0002735_abnormal_chemical_nociception1.21578664
49MP0008007_abnormal_cellular_replicative1.19656247
50MP0002132_abnormal_respiratory_system1.19162708
51MP0005275_abnormal_skin_tensile1.17724808
52MP0003786_premature_aging1.17457920
53MP0001727_abnormal_embryo_implantation1.14317158
54MP0001545_abnormal_hematopoietic_system1.07464246
55MP0005397_hematopoietic_system_phenotyp1.07464246
56MP0001542_abnormal_bone_strength1.07254993
57MP0001485_abnormal_pinna_reflex1.07072054
58MP0009046_muscle_twitch1.06950155
59MP0004233_abnormal_muscle_weight1.06717194
60MP0000750_abnormal_muscle_regeneration1.05604705
61MP0010155_abnormal_intestine_physiology1.03395854
62MP0000681_abnormal_thyroid_gland1.03258628
63MP0005165_increased_susceptibility_to1.01968473
64MP0000358_abnormal_cell_content/1.01397965
65MP0010234_abnormal_vibrissa_follicle0.99664858
66MP0005248_abnormal_Harderian_gland0.97092629
67MP0004957_abnormal_blastocyst_morpholog0.96895935
68MP0003077_abnormal_cell_cycle0.96057202
69MP0002234_abnormal_pharynx_morphology0.94207440
70MP0002638_abnormal_pupillary_reflex0.87723607
71MP0005501_abnormal_skin_physiology0.85338039
72MP0005365_abnormal_bile_salt0.85157989
73MP0008932_abnormal_embryonic_tissue0.83393212
74MP0002136_abnormal_kidney_physiology0.82756414
75MP0005408_hypopigmentation0.81663629
76MP0009643_abnormal_urine_homeostasis0.81487340
77MP0005220_abnormal_exocrine_pancreas0.79635619
78MP0000465_gastrointestinal_hemorrhage0.78204511
79MP0004808_abnormal_hematopoietic_stem0.76722815
80MP0001730_embryonic_growth_arrest0.76434374
81MP0003950_abnormal_plasma_membrane0.75530240
82MP0001849_ear_inflammation0.75206194
83MP0008872_abnormal_physiological_respon0.74711470
84MP0008438_abnormal_cutaneous_collagen0.72833254
85MP0005551_abnormal_eye_electrophysiolog0.70411494
86MP0000467_abnormal_esophagus_morphology0.69840015
87MP0001765_abnormal_ion_homeostasis0.69836764
88MP0002139_abnormal_hepatobiliary_system0.69746197
89MP0003195_calcinosis0.67593305
90MP0005647_abnormal_sex_gland0.67328046
91MP0003941_abnormal_skin_development0.66917769
92MP0005395_other_phenotype0.66653466
93MP0000350_abnormal_cell_proliferation0.66537831
94MP0005164_abnormal_response_to0.66321961
95MP0001502_abnormal_circadian_rhythm0.65940066
96MP0000026_abnormal_inner_ear0.65163428
97MP0002928_abnormal_bile_duct0.63629536
98MP0002098_abnormal_vibrissa_morphology0.63365119
99MP0001324_abnormal_eye_pigmentation0.62650831
100MP0003279_aneurysm0.62038250
101MP0004883_abnormal_blood_vessel0.61556452
102MP0003937_abnormal_limbs/digits/tail_de0.61451251
103MP0000049_abnormal_middle_ear0.61332935
104MP0001944_abnormal_pancreas_morphology0.61255635
105MP0008057_abnormal_DNA_replication0.60987121
106MP0002116_abnormal_craniofacial_bone0.60351280
107MP0005646_abnormal_pituitary_gland0.59974583
108MP0001664_abnormal_digestion0.59184598
109MP0003705_abnormal_hypodermis_morpholog0.58782529
110MP0009765_abnormal_xenobiotic_induced0.58748295
111MP0001270_distended_abdomen0.58514845
112MP0003942_abnormal_urinary_system0.58493214
113MP0001970_abnormal_pain_threshold0.57584154
114MP0008004_abnormal_stomach_pH0.57449594
115MP0003115_abnormal_respiratory_system0.57364840
116MP0005085_abnormal_gallbladder_physiolo0.57114881
117MP0005253_abnormal_eye_physiology0.57029191
118MP0000631_abnormal_neuroendocrine_gland0.56964072
119MP0002060_abnormal_skin_morphology0.56950191
120MP0003566_abnormal_cell_adhesion0.56885101
121MP0004264_abnormal_extraembryonic_tissu0.56698184
122MP0003699_abnormal_female_reproductive0.55859116
123MP0001188_hyperpigmentation0.55795836
124MP0005310_abnormal_salivary_gland0.55665381
125MP0001293_anophthalmia0.55218548
126MP0003890_abnormal_embryonic-extraembry0.53808025
127MP0003453_abnormal_keratinocyte_physiol0.53320811
128MP0003879_abnormal_hair_cell0.52451087
129MP0002405_respiratory_system_inflammati0.52016484
130MP0003136_yellow_coat_color0.51487959
131MP0002102_abnormal_ear_morphology0.49907000
132MP0002080_prenatal_lethality0.49674895
133MP0003303_peritoneal_inflammation0.49412536
134MP0005195_abnormal_posterior_eye0.49266414
135MP0005380_embryogenesis_phenotype0.49134963
136MP0001672_abnormal_embryogenesis/_devel0.49134963
137MP0003806_abnormal_nucleotide_metabolis0.48976052
138MP0009703_decreased_birth_body0.48106550
139MP0010352_gastrointestinal_tract_polyps0.47937665
140MP0005388_respiratory_system_phenotype0.47162863
141MP0002133_abnormal_respiratory_system0.47162863
142MP0002135_abnormal_kidney_morphology0.47126285
143MP0002092_abnormal_eye_morphology0.47036647
144MP0000647_abnormal_sebaceous_gland0.46602352
145MP0003938_abnormal_ear_development0.46369550
146MP0000313_abnormal_cell_death0.46306054
147MP0001963_abnormal_hearing_physiology0.46168086
148MP0000534_abnormal_ureter_morphology0.45826042
149MP0001299_abnormal_eye_distance/0.45748506
150MP0002896_abnormal_bone_mineralization0.45209520
151MP0003638_abnormal_response/metabolism_0.44296338
152MP0001119_abnormal_female_reproductive0.43726814
153MP0010771_integument_phenotype0.43057284
154MP0000733_abnormal_muscle_development0.41970721
155MP0002229_neurodegeneration0.41690551
156MP0005503_abnormal_tendon_morphology0.41098585
157MP0001216_abnormal_epidermal_layer0.40916526
158MP0003984_embryonic_growth_retardation0.39945247
159MP0002084_abnormal_developmental_patter0.39735074
160MP0002085_abnormal_embryonic_tissue0.39338894
161MP0005508_abnormal_skeleton_morphology0.39325339
162MP0004133_heterotaxia0.39257420
163MP0003091_abnormal_cell_migration0.39239712
164MP0009250_abnormal_appendicular_skeleto0.39219688
165MP0009333_abnormal_splenocyte_physiolog0.38383882
166MP0009115_abnormal_fat_cell0.36774245
167MP0003936_abnormal_reproductive_system0.36415409
168MP0000428_abnormal_craniofacial_morphol0.36193480
169MP0002088_abnormal_embryonic_growth/wei0.35978067
170MP0002736_abnormal_nociception_after0.35631554
171MP0001697_abnormal_embryo_size0.35529712
172MP0000427_abnormal_hair_cycle0.35149189
173MP0000013_abnormal_adipose_tissue0.35078132
174MP0005023_abnormal_wound_healing0.33915647
175MP0010386_abnormal_urinary_bladder0.33689614
176MP0004019_abnormal_vitamin_homeostasis0.33312178
177MP0002233_abnormal_nose_morphology0.33141026

Predicted human phenotypes

RankGene SetZ-score
1Abnormal ciliary motility (HP:0012262)9.04793820
2Abnormal respiratory motile cilium morphology (HP:0005938)8.93682680
3Abnormal respiratory epithelium morphology (HP:0012253)8.93682680
4Rhinitis (HP:0012384)8.00587925
5Chronic bronchitis (HP:0004469)7.43697765
6Nasal polyposis (HP:0100582)6.00774658
7Infertility (HP:0000789)5.83086900
8Abnormality of the nasal mucosa (HP:0000433)4.86891740
9Bronchiectasis (HP:0002110)4.86409356
10Male infertility (HP:0003251)4.19798265
11Bronchitis (HP:0012387)4.13141334
12Nephronophthisis (HP:0000090)3.67161565
13Recurrent sinusitis (HP:0011108)3.41786979
14Chronic otitis media (HP:0000389)3.12475873
15Recurrent otitis media (HP:0000403)3.07777651
16Molar tooth sign on MRI (HP:0002419)3.06467161
17Abnormality of midbrain morphology (HP:0002418)3.06467161
18Abnormal spermatogenesis (HP:0008669)2.98511650
19Pancreatic fibrosis (HP:0100732)2.83015876
20Hyperactive renin-angiotensin system (HP:0000841)2.70655901
21Abnormality of the renal medulla (HP:0100957)2.66792774
22Impulsivity (HP:0100710)2.66450554
23Tubular atrophy (HP:0000092)2.60026756
24Chronic hepatic failure (HP:0100626)2.55135770
25Short nail (HP:0001799)2.53375293
26True hermaphroditism (HP:0010459)2.32586269
27Premature rupture of membranes (HP:0001788)2.26262703
28Tubulointerstitial nephritis (HP:0001970)2.25894523
29Medial flaring of the eyebrow (HP:0010747)2.24566002
30Postaxial foot polydactyly (HP:0001830)2.02630937
31Abnormality of dentin (HP:0010299)2.02203467
32Aplasia/Hypoplasia of the tongue (HP:0010295)2.02162270
33Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.2946572
34Absent/shortened dynein arms (HP:0200106)11.9068301
35Dynein arm defect of respiratory motile cilia (HP:0012255)11.9068301
36Abnormal respiratory motile cilium physiology (HP:0012261)10.2999974
37Azoospermia (HP:0000027)1.96716856
38Asplenia (HP:0001746)1.96680379
39Pancreatic cysts (HP:0001737)1.95005267
40Facial cleft (HP:0002006)1.94744282
41Aplasia/Hypoplasia of the spleen (HP:0010451)1.93574880
42Recurrent bronchitis (HP:0002837)1.92770381
43Congenital hepatic fibrosis (HP:0002612)1.89077300
44Microglossia (HP:0000171)1.87261957
45Oculomotor apraxia (HP:0000657)1.85202098
46Cystic liver disease (HP:0006706)1.83888704
47Tubulointerstitial abnormality (HP:0001969)1.83668843
48Furrowed tongue (HP:0000221)1.78384875
49Decreased circulating renin level (HP:0003351)1.77213681
50Taurodontia (HP:0000679)1.77021339
51Abnormality of permanent molar morphology (HP:0011071)1.77021339
52Abnormality of the dental root (HP:0006486)1.77021339
53Hypoplasia of the capital femoral epiphysis (HP:0003090)1.75022427
54Stage 5 chronic kidney disease (HP:0003774)1.74529765
55Sclerocornea (HP:0000647)1.70218717
56Abnormality of molar (HP:0011077)1.70177921
57Abnormality of molar morphology (HP:0011070)1.70177921
58Renal salt wasting (HP:0000127)1.68290823
59Median cleft lip (HP:0000161)1.68130127
60Difficulty climbing stairs (HP:0003551)1.59790264
61Occipital encephalocele (HP:0002085)1.58850017
62Abnormality of the dental pulp (HP:0006479)1.58182200
63Chronic sinusitis (HP:0011109)1.57538814
64Degeneration of anterior horn cells (HP:0002398)1.55208171
65Abnormality of the anterior horn cell (HP:0006802)1.55208171
66Bile duct proliferation (HP:0001408)1.52954314
67Abnormal biliary tract physiology (HP:0012439)1.52954314
68Supernumerary spleens (HP:0009799)1.52281675
69Abnormality of the umbilical cord (HP:0010881)1.52004201
70Postaxial hand polydactyly (HP:0001162)1.48913513
71Hyperkalemia (HP:0002153)1.48057176
72Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.45129140
73Decreased central vision (HP:0007663)1.44788584
74Tubulointerstitial fibrosis (HP:0005576)1.44669434
75Protrusio acetabuli (HP:0003179)1.42499774
76Fibular hypoplasia (HP:0003038)1.41829771
77Broad distal phalanx of finger (HP:0009836)1.39952910
78Bundle branch block (HP:0011710)1.38229632
79Absent rod-and cone-mediated responses on ERG (HP:0007688)1.35582489
80Breast carcinoma (HP:0003002)1.34142136
81Gonadotropin excess (HP:0000837)1.33822586
82Osteolytic defects of the hand bones (HP:0009699)1.33693556
83Osteolytic defects of the phalanges of the hand (HP:0009771)1.33693556
84Sparse lateral eyebrow (HP:0005338)1.33540492
85Hyperaldosteronism (HP:0000859)1.33251134
86Congenital primary aphakia (HP:0007707)1.32981461
87Tongue fasciculations (HP:0001308)1.32631185
88Muscle fibrillation (HP:0010546)1.31058713
89Short ribs (HP:0000773)1.29846663
90Preaxial hand polydactyly (HP:0001177)1.29293384
91Abnormality of renin-angiotensin system (HP:0000847)1.28976470
92Bell-shaped thorax (HP:0001591)1.28287495
93Atelectasis (HP:0100750)1.27939937
94Gait imbalance (HP:0002141)1.27541253
95Aplasia/Hypoplasia of the lens (HP:0008063)1.26369576
96Abnormality of the distal phalanges of the toes (HP:0010182)1.24305901
97Abnormality of chloride homeostasis (HP:0011422)1.23843459
98Anencephaly (HP:0002323)1.23841064
99Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.23822947
100Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.23088440
101Absent epiphyses (HP:0010577)1.23088440
102Abnormality of the frontal sinuses (HP:0002687)1.21399126
103Short thorax (HP:0010306)1.21196289
104Short femoral neck (HP:0100864)1.19763519
105Glucose intolerance (HP:0000833)1.17006654
106Aplasia of the musculature (HP:0100854)1.16751899
107Absent frontal sinuses (HP:0002688)1.16664392
108Selective tooth agenesis (HP:0001592)1.16621600
109Aplasia/Hypoplasia of the fibula (HP:0006492)1.16044077
110Entropion (HP:0000621)1.15655661
111Spastic tetraparesis (HP:0001285)1.15486553
112Polydipsia (HP:0001959)1.14898824
113Abnormal drinking behavior (HP:0030082)1.14898824
114Fetal akinesia sequence (HP:0001989)1.14186447
115Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.13748853
116Renal dysplasia (HP:0000110)1.13723565
117Delayed gross motor development (HP:0002194)1.13433490
118J-shaped sella turcica (HP:0002680)1.11916171
119Cone-rod dystrophy (HP:0000548)1.11721922
120Nephrogenic diabetes insipidus (HP:0009806)1.10880108
121Nephropathy (HP:0000112)1.09248828
122Vaginal atresia (HP:0000148)1.08287632
123Genital tract atresia (HP:0001827)1.08033332
124Poor coordination (HP:0002370)1.07984882
125Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.07598948
126Abnormality of the renal cortex (HP:0011035)1.06732418
127Abnormality of renal excretion (HP:0011036)1.06568005
128Hypokalemic alkalosis (HP:0001949)1.06368060
129Hand muscle atrophy (HP:0009130)1.06230809
130Obstructive sleep apnea (HP:0002870)1.04579657
131Male pseudohermaphroditism (HP:0000037)1.03921703
132Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.03710416
133Hyponatremia (HP:0002902)1.02733454
134Bifid scrotum (HP:0000048)1.01838598
135Carpal bone hypoplasia (HP:0001498)1.00467828
136Popliteal pterygium (HP:0009756)1.00192096
137Abnormality of the middle phalanges of the toes (HP:0010183)0.98227725
138Lip pit (HP:0100267)0.97565472

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.78426987
2PDK37.78426987
3TESK15.03001676
4PDK24.99174064
5PRKD33.22856819
6PNCK2.60778527
7ICK2.53001197
8WEE12.12098567
9PTK2B2.10334936
10NEK22.05990402
11SMG11.84275442
12MAP3K21.79728012
13STK241.63198368
14DYRK31.60892723
15PIM21.57931075
16STK381.55613377
17STK38L1.55054763
18CSK1.49025644
19BUB11.44840261
20STK31.41264643
21EPHA21.29475490
22MAP3K31.28249894
23TTK1.26107709
24BRSK21.24440577
25BCR1.21444091
26WNK41.16029832
27EPHB11.12860638
28PLK41.12537425
29PAK21.07338533
30MST1R1.06189813
31DYRK1B1.04019169
32NEK61.02233225
33TRPM70.99295449
34MAP3K70.98816239
35EPHA30.96465164
36STK390.95862396
37EIF2AK10.94566666
38PRKCI0.90973685
39TBK10.89309039
40WNK10.86472836
41LRRK20.86436514
42PLK10.85878627
43CHEK20.83646061
44NME20.81130778
45MOS0.80718085
46RPS6KA40.78034606
47PAK10.77768364
48STK160.77441937
49MARK20.76811749
50GRK60.76113832
51MAPK150.75377134
52EEF2K0.72951857
53ZAK0.72297833
54ERBB20.69806081
55LATS20.69793221
56INSRR0.68215247
57TESK20.65481969
58AURKA0.65100584
59CHEK10.63793788
60ADRBK20.62759470
61PDK10.60889726
62PINK10.59229804
63IRAK10.57725085
64AURKB0.56214971
65PRKD20.55826712
66BRSK10.53969535
67EIF2AK30.53870630
68SRPK10.51072737
69ATR0.50178770
70IRAK20.49301159
71AKT30.49299711
72MAP2K20.49137335
73FRK0.47726119
74MAP3K120.47512708
75NME10.47154675
76PRKCG0.46427264
77PLK30.44474491
78PRKCQ0.43849570
79MAP3K40.42934402
80PRPF4B0.42614744
81STK100.41777408
82RIPK40.41266033
83SGK10.41150971
84TSSK60.40509947
85PRKCD0.40442436
86HIPK20.39835435
87MUSK0.38225371
88ATM0.37509102
89MAPKAPK30.37140147
90CAMK2G0.36711319
91TAOK10.36691714
92PRKAA20.36011430
93MTOR0.35534360
94MAP2K60.35010200
95NLK0.34982592
96ADRBK10.34146805
97MAPKAPK50.33574529
98TTN0.33201215
99LMTK20.33017089
100CDC70.32932881
101CAMKK20.32634800
102RPS6KB20.32101693
103DDR20.31443174
104BRAF0.31095791
105RPS6KA50.30851825
106NEK90.30432318
107TLK10.29301308
108CDC42BPA0.29103183
109TRIB30.28589729
110RIPK10.27934738
111ZAP700.27509594
112PAK60.27284757
113LIMK10.26485589
114ACVR1B0.25998626
115CSNK1E0.25466426
116GRK10.25465122
117OXSR10.25100020
118CCNB10.24684665
119MAP2K40.24524579
120ABL10.24313789
121PRKACA0.22893348
122NEK10.22389361
123PRKCA0.22022020
124PASK0.21524524
125MST40.21202391
126TAOK20.20857518
127MAP2K10.20243884
128EIF2AK20.20076580
129DYRK1A0.19906260
130RPS6KA20.19817196
131MET0.19260194
132MAP4K20.18902915
133PDPK10.18415325
134FGFR30.18396266
135CSNK2A10.18213661
136CAMKK10.17938226
137IRAK30.17922525
138CSNK2A20.17645853
139BMPR1B0.16973077
140CDK20.16923243
141ERBB30.16805798
142PRKCZ0.16529408
143MARK30.16333052
144LATS10.16209980
145CDK140.16189977
146PAK40.15984421
147PTK60.15731479
148AKT20.15299626
149CDK70.15172622
150ARAF0.14785307
151PRKG20.14710012
152PRKDC0.14661298
153FER0.13951435
154CHUK0.12671749
155MATK0.12621322
156MAP2K70.12529378
157ROCK10.12194542
158CAMK2A0.11707374
159SIK20.10766277
160STK110.10073299
161SRC0.09586292
162FYN0.09334420

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007506.82217981
2Phenylalanine metabolism_Homo sapiens_hsa003604.73119110
3Chemical carcinogenesis_Homo sapiens_hsa052044.64660821
4Histidine metabolism_Homo sapiens_hsa003404.60787739
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.30381084
6Tyrosine metabolism_Homo sapiens_hsa003503.72916515
7Basal transcription factors_Homo sapiens_hsa030223.11696524
8beta-Alanine metabolism_Homo sapiens_hsa004103.07788074
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.65484844
10RNA transport_Homo sapiens_hsa030132.56144701
11Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.47602875
12Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.43490845
13Fatty acid biosynthesis_Homo sapiens_hsa000612.42756997
14Caffeine metabolism_Homo sapiens_hsa002322.38521887
15Pentose phosphate pathway_Homo sapiens_hsa000302.33612964
16Retinol metabolism_Homo sapiens_hsa008302.29960550
17Proteasome_Homo sapiens_hsa030502.21450313
18Fanconi anemia pathway_Homo sapiens_hsa034602.01240011
19Pyrimidine metabolism_Homo sapiens_hsa002401.97414324
20Linoleic acid metabolism_Homo sapiens_hsa005911.92654336
21Purine metabolism_Homo sapiens_hsa002301.92631847
22Oocyte meiosis_Homo sapiens_hsa041141.86364759
23Glycerophospholipid metabolism_Homo sapiens_hsa005641.84155885
24Mineral absorption_Homo sapiens_hsa049781.80946682
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.79785106
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.76141418
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.69684577
28Cell cycle_Homo sapiens_hsa041101.66442993
29ABC transporters_Homo sapiens_hsa020101.55979486
30Pyruvate metabolism_Homo sapiens_hsa006201.50941273
31Steroid hormone biosynthesis_Homo sapiens_hsa001401.50092616
32Glucagon signaling pathway_Homo sapiens_hsa049221.44178355
33Glycerolipid metabolism_Homo sapiens_hsa005611.40359177
34RNA polymerase_Homo sapiens_hsa030201.39828387
35Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.39277974
36Collecting duct acid secretion_Homo sapiens_hsa049661.35856541
37Antigen processing and presentation_Homo sapiens_hsa046121.34806527
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.33267081
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.31314803
40Renin-angiotensin system_Homo sapiens_hsa046141.30697364
41Sphingolipid metabolism_Homo sapiens_hsa006001.29586055
42Fructose and mannose metabolism_Homo sapiens_hsa000511.28283559
43Spliceosome_Homo sapiens_hsa030401.22618728
44p53 signaling pathway_Homo sapiens_hsa041151.21707873
45Arachidonic acid metabolism_Homo sapiens_hsa005901.15283705
46Epstein-Barr virus infection_Homo sapiens_hsa051691.14106892
47Fatty acid degradation_Homo sapiens_hsa000711.13473477
48Olfactory transduction_Homo sapiens_hsa047401.12892110
49Vitamin digestion and absorption_Homo sapiens_hsa049771.11573902
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.10646327
51Sulfur relay system_Homo sapiens_hsa041221.08862735
52Peroxisome_Homo sapiens_hsa041461.08664924
53Carbohydrate digestion and absorption_Homo sapiens_hsa049731.08433628
54Huntingtons disease_Homo sapiens_hsa050161.06485278
55Salivary secretion_Homo sapiens_hsa049701.03507092
56Selenocompound metabolism_Homo sapiens_hsa004501.02312916
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01103127
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99762443
59mRNA surveillance pathway_Homo sapiens_hsa030150.98018677
60Ether lipid metabolism_Homo sapiens_hsa005650.96830745
61Glutathione metabolism_Homo sapiens_hsa004800.94528234
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91711786
63Starch and sucrose metabolism_Homo sapiens_hsa005000.91704222
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.91113076
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.87302194
66Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80559640
67Viral carcinogenesis_Homo sapiens_hsa052030.78389472
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78141650
69Biosynthesis of amino acids_Homo sapiens_hsa012300.77871149
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76582957
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76183791
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75747549
73Nucleotide excision repair_Homo sapiens_hsa034200.75689125
74DNA replication_Homo sapiens_hsa030300.75020840
75Base excision repair_Homo sapiens_hsa034100.73767271
76Legionellosis_Homo sapiens_hsa051340.69975217
77Carbon metabolism_Homo sapiens_hsa012000.69197050
78Homologous recombination_Homo sapiens_hsa034400.68696443
79Amphetamine addiction_Homo sapiens_hsa050310.68431087
80Dorso-ventral axis formation_Homo sapiens_hsa043200.68082702
81Basal cell carcinoma_Homo sapiens_hsa052170.64106232
82Notch signaling pathway_Homo sapiens_hsa043300.64027154
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63690262
84Hepatitis C_Homo sapiens_hsa051600.63657892
85Rheumatoid arthritis_Homo sapiens_hsa053230.63110881
86Synaptic vesicle cycle_Homo sapiens_hsa047210.61640615
87Nicotine addiction_Homo sapiens_hsa050330.61502703
88Fat digestion and absorption_Homo sapiens_hsa049750.61387054
89Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.61235689
90Choline metabolism in cancer_Homo sapiens_hsa052310.61136917
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57123173
92Inositol phosphate metabolism_Homo sapiens_hsa005620.54700207
93Tight junction_Homo sapiens_hsa045300.54408631
94RNA degradation_Homo sapiens_hsa030180.52862287
95Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51668416
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.50913833
97Primary bile acid biosynthesis_Homo sapiens_hsa001200.50900536
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50750215
99Hedgehog signaling pathway_Homo sapiens_hsa043400.49868473
100Endocytosis_Homo sapiens_hsa041440.48144939
101Propanoate metabolism_Homo sapiens_hsa006400.47885569
102HTLV-I infection_Homo sapiens_hsa051660.46872726
103Hematopoietic cell lineage_Homo sapiens_hsa046400.45381300
104Non-homologous end-joining_Homo sapiens_hsa034500.44901441
105Taste transduction_Homo sapiens_hsa047420.44449997
106PPAR signaling pathway_Homo sapiens_hsa033200.44067179
107Phagosome_Homo sapiens_hsa041450.44021683
108Estrogen signaling pathway_Homo sapiens_hsa049150.42940892
109Salmonella infection_Homo sapiens_hsa051320.40594298
110Phototransduction_Homo sapiens_hsa047440.39912774
111Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39840610
112Ribosome_Homo sapiens_hsa030100.38282662
113Cocaine addiction_Homo sapiens_hsa050300.37906248
114cAMP signaling pathway_Homo sapiens_hsa040240.37574469
115Renin secretion_Homo sapiens_hsa049240.37288257
116Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37154110
117Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36951788
118Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36826507
119Tryptophan metabolism_Homo sapiens_hsa003800.36244136
120Maturity onset diabetes of the young_Homo sapiens_hsa049500.35698393
121Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35510258
122Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.35152756
123Serotonergic synapse_Homo sapiens_hsa047260.35081037
124Shigellosis_Homo sapiens_hsa051310.34527755
125Intestinal immune network for IgA production_Homo sapiens_hsa046720.34216773
126Metabolic pathways_Homo sapiens_hsa011000.32679725
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.32558292
128Complement and coagulation cascades_Homo sapiens_hsa046100.31195898
129Adherens junction_Homo sapiens_hsa045200.30092338
130Calcium signaling pathway_Homo sapiens_hsa040200.29159940
131Type I diabetes mellitus_Homo sapiens_hsa049400.27628447
132Lysosome_Homo sapiens_hsa041420.27319335
133Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.27139103
134Vibrio cholerae infection_Homo sapiens_hsa051100.26756438
135Insulin secretion_Homo sapiens_hsa049110.26413592
136Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.26065416
137Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.26035309
138Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25860703
139Small cell lung cancer_Homo sapiens_hsa052220.25409027
140Systemic lupus erythematosus_Homo sapiens_hsa053220.24983768
141Ovarian steroidogenesis_Homo sapiens_hsa049130.24952347
142Protein digestion and absorption_Homo sapiens_hsa049740.24630462
143Drug metabolism - other enzymes_Homo sapiens_hsa009830.24225969
144Herpes simplex infection_Homo sapiens_hsa051680.24201286
145HIF-1 signaling pathway_Homo sapiens_hsa040660.24115612
146Insulin resistance_Homo sapiens_hsa049310.23159899
147Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.22647171
148Cardiac muscle contraction_Homo sapiens_hsa042600.22277227
149Arginine and proline metabolism_Homo sapiens_hsa003300.22232831
150Hippo signaling pathway_Homo sapiens_hsa043900.22169885
151Nitrogen metabolism_Homo sapiens_hsa009100.21699738
152Asthma_Homo sapiens_hsa053100.21295189
153Thyroid hormone synthesis_Homo sapiens_hsa049180.20855055
154Circadian rhythm_Homo sapiens_hsa047100.20586973
155Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19365871
156Graft-versus-host disease_Homo sapiens_hsa053320.18121841
157Cyanoamino acid metabolism_Homo sapiens_hsa004600.17647834
158Jak-STAT signaling pathway_Homo sapiens_hsa046300.15943925
159Bile secretion_Homo sapiens_hsa049760.15865851
160Allograft rejection_Homo sapiens_hsa053300.14807897
161Pancreatic secretion_Homo sapiens_hsa049720.14335232
162Autoimmune thyroid disease_Homo sapiens_hsa053200.14098188
163Axon guidance_Homo sapiens_hsa043600.11311074
164RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.08534703
165Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.08406950
166Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.08399063
167Amoebiasis_Homo sapiens_hsa051460.06881692
168Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.06477399
169Melanogenesis_Homo sapiens_hsa049160.06083635

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