CFAP161

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1GTP biosynthetic process (GO:0006183)9.43377780
2nucleoside diphosphate phosphorylation (GO:0006165)8.39574601
3UTP biosynthetic process (GO:0006228)8.38002730
4UTP metabolic process (GO:0046051)7.73460657
5left/right axis specification (GO:0070986)7.73183017
6protein neddylation (GO:0045116)7.72517879
7sperm motility (GO:0030317)7.27889877
8thrombin receptor signaling pathway (GO:0070493)6.78219343
9neutrophil activation involved in immune response (GO:0002283)6.73615509
10intraciliary transport (GO:0042073)6.65892357
11regulation of cilium movement (GO:0003352)6.46059783
12guanosine-containing compound biosynthetic process (GO:1901070)6.42371813
13fusion of sperm to egg plasma membrane (GO:0007342)6.41340227
14CTP biosynthetic process (GO:0006241)6.21060222
15CTP metabolic process (GO:0046036)6.21060222
16acrosome assembly (GO:0001675)6.02264980
17cilium organization (GO:0044782)5.95342353
18regulation of platelet aggregation (GO:0090330)5.90209031
19microtubule bundle formation (GO:0001578)5.74897372
20pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)5.65273023
21regulation of platelet activation (GO:0010543)5.64948231
22multicellular organism reproduction (GO:0032504)5.62340611
23cilium assembly (GO:0042384)5.53669127
24sperm-egg recognition (GO:0035036)5.51959692
25negative regulation of thymocyte apoptotic process (GO:0070244)5.48873528
26spermatid development (GO:0007286)5.46755795
27positive regulation of endothelial cell differentiation (GO:0045603)5.37772590
28cell wall macromolecule catabolic process (GO:0016998)5.34873629
29cell wall macromolecule metabolic process (GO:0044036)5.34873629
30triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.34492371
31pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)5.33912075
32acrosome reaction (GO:0007340)5.32386389
33negative regulation of inclusion body assembly (GO:0090084)5.28115663
34lipoxygenase pathway (GO:0019372)5.26134072
35blood coagulation, intrinsic pathway (GO:0007597)5.24314390
36leukocyte migration involved in inflammatory response (GO:0002523)5.17001686
37negative regulation of homotypic cell-cell adhesion (GO:0034111)5.16952759
38negative regulation of heart rate (GO:0010459)5.11319665
39platelet aggregation (GO:0070527)5.08635606
40binding of sperm to zona pellucida (GO:0007339)5.06225796
41adenosine receptor signaling pathway (GO:0001973)5.05540452
42cilium morphogenesis (GO:0060271)5.03080913
43cellular component assembly involved in morphogenesis (GO:0010927)4.94063766
44negative regulation of norepinephrine secretion (GO:0010700)4.93607157
45negative regulation of platelet activation (GO:0010544)4.90419567
46pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)4.88222687
47plasma membrane fusion (GO:0045026)4.85941415
48cell-cell recognition (GO:0009988)4.85836833
49regulation of integrin-mediated signaling pathway (GO:2001044)4.83441981
50microtubule-based movement (GO:0007018)4.82602008
51polyamine biosynthetic process (GO:0006596)4.71867392
52single fertilization (GO:0007338)4.66622125
53microtubule severing (GO:0051013)4.64572701
54microtubule depolymerization (GO:0007019)4.58187310
55nucleotide phosphorylation (GO:0046939)4.57315585
56negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)4.50551382
57reproduction (GO:0000003)4.49785354
58male meiosis (GO:0007140)4.47932003
59negative regulation of appetite (GO:0032099)4.45158580
60negative regulation of response to food (GO:0032096)4.45158580
61piRNA metabolic process (GO:0034587)4.44852601
62G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.29895355
63pyrimidine nucleoside triphosphate metabolic process (GO:0009147)4.27382607
64angiogenesis involved in wound healing (GO:0060055)4.25749735
65synaptonemal complex organization (GO:0070193)4.23914793
66positive regulation of cAMP-mediated signaling (GO:0043950)4.16291708
67sperm capacitation (GO:0048240)4.13539753
68platelet degranulation (GO:0002576)4.06614669
69nucleoside diphosphate metabolic process (GO:0009132)4.04925543
70negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.03495280
71low-density lipoprotein particle remodeling (GO:0034374)4.00430227
72regulation of inclusion body assembly (GO:0090083)3.99336535
73regulation of integrin activation (GO:0033623)3.93692207
74regulation of microtubule-based movement (GO:0060632)3.93647280
75left/right pattern formation (GO:0060972)3.92686472
76cell projection assembly (GO:0030031)3.92189172
77fertilization (GO:0009566)3.88795553
78long-chain fatty acid biosynthetic process (GO:0042759)3.86485246
79male meiosis I (GO:0007141)3.78189263
80purinergic nucleotide receptor signaling pathway (GO:0035590)3.78185506
81protein localization to cilium (GO:0061512)3.74266787
82platelet formation (GO:0030220)3.74099524
83regulation of MHC class II biosynthetic process (GO:0045346)3.72408415
84megakaryocyte development (GO:0035855)3.70551482
85extracellular fibril organization (GO:0043206)3.69103432
86positive regulation of macrophage differentiation (GO:0045651)3.69080608
87negative regulation of protein localization to cell surface (GO:2000009)3.68464530
88spermatogenesis (GO:0007283)3.67144355
89neutrophil activation (GO:0042119)3.66286988
90male gamete generation (GO:0048232)3.65192720
91one-carbon compound transport (GO:0019755)3.61542807
92positive regulation of mast cell activation (GO:0033005)3.59385142
93pyrimidine ribonucleoside biosynthetic process (GO:0046132)3.55654565
94regulation of endothelial cell differentiation (GO:0045601)3.52287841
95platelet activation (GO:0030168)3.51062797
96negative regulation of heart contraction (GO:0045822)3.49188272
97positive regulation of systemic arterial blood pressure (GO:0003084)3.47003420
98homotypic cell-cell adhesion (GO:0034109)3.46649767
99meiotic cell cycle (GO:0051321)3.44735978
100regulation of homotypic cell-cell adhesion (GO:0034110)3.43052406
101axon ensheathment in central nervous system (GO:0032291)3.41851488
102central nervous system myelination (GO:0022010)3.41851488
103pyrimidine ribonucleotide biosynthetic process (GO:0009220)3.41407756
104regulation of lipoprotein metabolic process (GO:0050746)3.39057427
105gamete generation (GO:0007276)3.37878809
106cellular biogenic amine biosynthetic process (GO:0042401)3.36095195
107regulation of macrophage chemotaxis (GO:0010758)3.33243939
108protein polyglutamylation (GO:0018095)3.28068686
109spermatid nucleus differentiation (GO:0007289)3.26199429
110regulation of norepinephrine secretion (GO:0014061)3.24989875
111centriole assembly (GO:0098534)3.24898704
112positive regulation of blood coagulation (GO:0030194)3.24430723
113positive regulation of hemostasis (GO:1900048)3.24430723
114regulation of macrophage derived foam cell differentiation (GO:0010743)3.24142925
115centriole replication (GO:0007099)3.23388431
116otic vesicle formation (GO:0030916)3.23317476
117oxygen transport (GO:0015671)3.22789816
118regulation of megakaryocyte differentiation (GO:0045652)3.21402347
119amine biosynthetic process (GO:0009309)3.20124054
120purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.19565781
121negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.18745438
122determination of left/right symmetry (GO:0007368)3.17550806
123granulocyte activation (GO:0036230)3.16598193
124regulation of glucose import in response to insulin stimulus (GO:2001273)3.13138055
125purinergic receptor signaling pathway (GO:0035587)3.11542980
126superoxide anion generation (GO:0042554)3.11272584
127regulation of mononuclear cell migration (GO:0071675)3.10939390
128G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.10540373
129pyrimidine ribonucleotide metabolic process (GO:0009218)3.09938300
130purine nucleoside triphosphate biosynthetic process (GO:0009145)3.09435218
131positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.08799465
132synaptonemal complex assembly (GO:0007130)3.08224896
133autophagic vacuole fusion (GO:0000046)3.07129300
134determination of bilateral symmetry (GO:0009855)3.06995081
135negative regulation of catecholamine secretion (GO:0033604)3.06929357
136cardiolipin metabolic process (GO:0032048)3.06895954
137negative regulation of T cell apoptotic process (GO:0070233)3.06124231
138fibril organization (GO:0097435)3.02508509
139regulation of Golgi to plasma membrane protein transport (GO:0042996)3.02424960
140dopamine transport (GO:0015872)3.02267436
141positive regulation of receptor recycling (GO:0001921)3.01776943
142positive regulation of Rho protein signal transduction (GO:0035025)3.01456168
143high-density lipoprotein particle remodeling (GO:0034375)3.01414238
144specification of symmetry (GO:0009799)3.01224576
145beta-amyloid metabolic process (GO:0050435)2.99467449
146germ cell development (GO:0007281)2.96531725
147cyclooxygenase pathway (GO:0019371)2.94892599
148regulation of cAMP-dependent protein kinase activity (GO:2000479)2.92662114
149polyamine metabolic process (GO:0006595)2.90742606
150cellular biogenic amine catabolic process (GO:0042402)2.90476053
151amine catabolic process (GO:0009310)2.90476053
152gas transport (GO:0015669)2.89873256
153protein refolding (GO:0042026)2.89579726
154termination of G-protein coupled receptor signaling pathway (GO:0038032)2.89111347
155meiosis I (GO:0007127)2.87446020
156reverse cholesterol transport (GO:0043691)2.84876314
157positive regulation of coagulation (GO:0050820)2.83418466
158termination of signal transduction (GO:0023021)2.80017478
159innate immune response in mucosa (GO:0002227)2.79660486
160negative regulation of neural precursor cell proliferation (GO:2000178)2.79546760
161positive regulation of meiosis (GO:0045836)2.79479757
162cellular process involved in reproduction in multicellular organism (GO:0022412)2.78549572
163regulation of blood coagulation (GO:0030193)2.78319829
164regulation of hemostasis (GO:1900046)2.78319829
165regulation of response to food (GO:0032095)2.76580652
166DNA methylation involved in gamete generation (GO:0043046)2.76445009
167intra-S DNA damage checkpoint (GO:0031573)2.75331382
168smoothened signaling pathway (GO:0007224)2.75156856
169embryonic camera-type eye development (GO:0031076)2.73565103
170nucleoside triphosphate biosynthetic process (GO:0009142)2.72391677
171pyrimidine ribonucleoside metabolic process (GO:0046131)2.71100515
172ribonucleoside triphosphate biosynthetic process (GO:0009201)2.68515554
173pyrimidine nucleotide biosynthetic process (GO:0006221)2.67679201
174multicellular organismal reproductive process (GO:0048609)2.67289065
175photoreceptor cell differentiation (GO:0046530)2.66218175
176eye photoreceptor cell differentiation (GO:0001754)2.66218175
177regulation of pigment cell differentiation (GO:0050932)2.65580822
178organic cation transport (GO:0015695)2.65468080
179cilium movement (GO:0003341)16.5675885
180axonemal dynein complex assembly (GO:0070286)16.4733472
181cilium or flagellum-dependent cell motility (GO:0001539)15.9664018
182epithelial cilium movement (GO:0003351)13.2110002
183axoneme assembly (GO:0035082)12.2250761
184epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)10.6070625
185ventricular system development (GO:0021591)10.2393953
186motile cilium assembly (GO:0044458)10.1747442

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human4.72318324
2GATA1_19941826_ChIP-Seq_K562_Human3.84046610
3SCL_19346495_ChIP-Seq_HPC-7_Human3.83242624
4LYL1_20887958_ChIP-Seq_HPC-7_Mouse3.54492919
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.42417217
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.41044424
7RBPJ_22232070_ChIP-Seq_NCS_Mouse3.35111165
8GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.21273014
9GATA2_19941826_ChIP-Seq_K562_Human3.14743749
10EZH2_22144423_ChIP-Seq_EOC_Human3.07598037
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.04388664
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.92153285
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.79568805
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.50877523
15GATA2_21666600_ChIP-Seq_HMVEC_Human2.47767943
16LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.39307541
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.38217585
18CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.32836811
19GATA1_19941827_ChIP-Seq_MEL_Mouse2.30245587
20SPI1_23127762_ChIP-Seq_K562_Human2.29665501
21GATA1_26923725_Chip-Seq_HPCs_Mouse2.14846279
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.08922707
23PCGF2_27294783_Chip-Seq_ESCs_Mouse2.08551895
24SRY_22984422_ChIP-ChIP_TESTIS_Rat2.07632066
25FLI1_27457419_Chip-Seq_LIVER_Mouse2.07020214
26Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.04177226
27SUZ12_27294783_Chip-Seq_NPCs_Mouse2.00067743
28CBX2_27304074_Chip-Seq_ESCs_Mouse1.99685313
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.96848547
30GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.95241875
31FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.94480644
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.91817632
33RNF2_27304074_Chip-Seq_NSC_Mouse1.88731245
34TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.88147762
35GATA1_22383799_ChIP-Seq_G1ME_Mouse1.86314109
36PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.83678274
37TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.81995992
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.80727105
39HTT_18923047_ChIP-ChIP_STHdh_Human1.80042875
40NFE2_27457419_Chip-Seq_LIVER_Mouse1.77473080
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75272573
42GATA1_22025678_ChIP-Seq_K562_Human1.73665977
43EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.70695672
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.64831665
45SMAD4_21799915_ChIP-Seq_A2780_Human1.62264429
46STAT1_20625510_ChIP-Seq_HELA_Human1.57912844
47TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57865738
48EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.52428564
49NANOG_18555785_Chip-Seq_ESCs_Mouse1.52132576
50VDR_22108803_ChIP-Seq_LS180_Human1.51867016
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.51621389
52IRF8_21731497_ChIP-ChIP_J774_Mouse1.48183945
53BCAT_22108803_ChIP-Seq_LS180_Human1.47457673
54POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.45458945
55TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45458945
56EZH2_27294783_Chip-Seq_NPCs_Mouse1.45306625
57NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.45016625
58NCOR1_26117541_ChIP-Seq_K562_Human1.44551689
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42475565
60P300_19829295_ChIP-Seq_ESCs_Human1.41575561
61MYB_21317192_ChIP-Seq_ERMYB_Mouse1.41252529
62KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.41165568
63EZH2_27294783_Chip-Seq_ESCs_Mouse1.39219003
64STAT3_18555785_Chip-Seq_ESCs_Mouse1.38813572
65TAL1_26923725_Chip-Seq_HPCs_Mouse1.38477679
66TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.37688238
67P53_22387025_ChIP-Seq_ESCs_Mouse1.37472991
68ER_23166858_ChIP-Seq_MCF-7_Human1.36653588
69RUNX1_22412390_ChIP-Seq_EML_Mouse1.35152184
70SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.34710816
71BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34136779
72KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.33746245
73GATA1_19941827_ChIP-Seq_MEL86_Mouse1.33597073
74CDX2_19796622_ChIP-Seq_MESCs_Mouse1.33595013
75P300_18555785_Chip-Seq_ESCs_Mouse1.33170662
76OCT4_18555785_Chip-Seq_ESCs_Mouse1.32512266
77NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.32398135
78NRF2_20460467_ChIP-Seq_MEFs_Mouse1.32398135
79ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32355515
80CRX_20693478_ChIP-Seq_RETINA_Mouse1.32097412
81E2F1_18555785_Chip-Seq_ESCs_Mouse1.31843107
82SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31764739
83LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31409882
84SALL4_22934838_ChIP-ChIP_CD34+_Human1.31371335
85CMYC_18555785_Chip-Seq_ESCs_Mouse1.30860766
86NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30644652
87IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.30609461
88SUZ12_18555785_Chip-Seq_ESCs_Mouse1.30464425
89POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28952088
90SMAD3_21741376_ChIP-Seq_EPCs_Human1.27946633
91PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27317211
92SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.27304386
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27098832
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.27009056
95TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26801048
96EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.26612921
97ZFX_18555785_Chip-Seq_ESCs_Mouse1.26172646
98FUS_26573619_Chip-Seq_HEK293_Human1.26150792
99KAP1_22055183_ChIP-Seq_ESCs_Mouse1.25241969
100SUZ12_27294783_Chip-Seq_ESCs_Mouse1.25202315
101SOX2_18555785_Chip-Seq_ESCs_Mouse1.24786401
102RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.24761454
103OCT4_21477851_ChIP-Seq_ESCs_Mouse1.24628961
104STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.23260518
105WDR5_24793694_ChIP-Seq_LNCAP_Human1.23183285
106IRF8_27001747_Chip-Seq_BMDM_Mouse1.22902292
107NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21927612
108SPI1_20517297_ChIP-Seq_HL60_Human1.21786562
109EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20821515
110PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.20803220
111TAF15_26573619_Chip-Seq_HEK293_Human1.20773163
112EWS_26573619_Chip-Seq_HEK293_Human1.20727224
113ESRRB_18555785_Chip-Seq_ESCs_Mouse1.18882881
114IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18759222
115CBP_20019798_ChIP-Seq_JUKART_Human1.18759222
116KLF4_18555785_Chip-Seq_ESCs_Mouse1.18662234
117MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17711518
118AR_21572438_ChIP-Seq_LNCaP_Human1.17195096
119REST_21632747_ChIP-Seq_MESCs_Mouse1.16675275
120RUNX_20019798_ChIP-Seq_JUKART_Human1.16630197
121FLI1_21867929_ChIP-Seq_TH2_Mouse1.16271410
122PU1_27457419_Chip-Seq_LIVER_Mouse1.14705476
123PIAS1_25552417_ChIP-Seq_VCAP_Human1.14682171
124SMAD4_21741376_ChIP-Seq_EPCs_Human1.14534826
125ERG_20517297_ChIP-Seq_VCAP_Human1.12719419
126PHF8_20622853_ChIP-Seq_HELA_Human1.12505398
127GATA3_21878914_ChIP-Seq_MCF-7_Human1.11800097
128TBL1_22424771_ChIP-Seq_293T_Human1.11512969
129TCF4_22108803_ChIP-Seq_LS180_Human1.10614793
130HNFA_21074721_ChIP-Seq_CACO-2_Human1.10508305
131NFYA_21822215_ChIP-Seq_K562_Human1.10350170
132CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.09898229
133RUNX1_27457419_Chip-Seq_LIVER_Mouse1.09725659
134SMRT_27268052_Chip-Seq_Bcells_Human1.09709069
135TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09244989
136SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.09109128
137LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08779123
138CEBPB_22108803_ChIP-Seq_LS180_Human1.08121428
139TCF4_23295773_ChIP-Seq_U87_Human1.07584340
140ELK4_26923725_Chip-Seq_MESODERM_Mouse1.06988788
141KDM2B_26808549_Chip-Seq_REH_Human1.06901284
142STAT3_23295773_ChIP-Seq_U87_Human1.06633098
143NMYC_18555785_Chip-Seq_ESCs_Mouse1.05708761
144HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05445584
145RBPJ_21746931_ChIP-Seq_IB4_Human1.05169034
146DROSHA_22980978_ChIP-Seq_HELA_Human1.04195886
147CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03167832
148IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.02956048
149GF1_26923725_Chip-Seq_HPCs_Mouse1.02947962
150GBX2_23144817_ChIP-Seq_PC3_Human1.02792454
151STAT1_17558387_ChIP-Seq_HELA_Human1.02133089
152CTCF_18555785_Chip-Seq_ESCs_Mouse1.01561680
153OCT1_27270436_Chip-Seq_PROSTATE_Human1.01350820
154EZH2_27304074_Chip-Seq_ESCs_Mouse1.01225123
155EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00941069
156SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.00412090
157ARNT_22903824_ChIP-Seq_MCF-7_Human1.00169669
158NFYB_21822215_ChIP-Seq_K562_Human0.98807715
159PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98590469
160CDX2_22108803_ChIP-Seq_LS180_Human0.96619298
161GATA4_25053715_ChIP-Seq_YYC3_Human0.96402028
162GATA6_21074721_ChIP-Seq_CACO-2_Human0.95940000
163IRF1_19129219_ChIP-ChIP_H3396_Human0.95538510
164ESR1_20079471_ChIP-ChIP_T-47D_Human0.94672653
165WT1_19549856_ChIP-ChIP_CCG9911_Human0.93250886
166SOX2_20726797_ChIP-Seq_SW620_Human0.90956064
167AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90844657
168FOXA1_27270436_Chip-Seq_PROSTATE_Human0.90639151
169FOXA1_25329375_ChIP-Seq_VCAP_Human0.90639151
170AR_20517297_ChIP-Seq_VCAP_Human0.89437582
171ETV1_20927104_ChIP-Seq_GIST48_Human0.89059832
172STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.88766304
173FOXM1_26456572_ChIP-Seq_MCF-7_Human0.86691420
174PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.86644251
175SOX2_22085726_ChIP-Seq_NPCs_Mouse0.85744510
176CBX2_22325352_ChIP-Seq_293T-Rex_Human0.85597220
177PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.85446501
178TCF4_18268006_ChIP-ChIP_LS174T_Human0.84620060
179TDRD3_21172665_ChIP-Seq_MCF-7_Human0.83984071
180FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83842364
181GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.82916932

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology9.47000884
2MP0005410_abnormal_fertilization7.61188557
3MP0003136_yellow_coat_color7.03192792
4MP0002653_abnormal_ependyma_morphology4.93804609
5MP0005623_abnormal_meninges_morphology4.48802848
6MP0008004_abnormal_stomach_pH3.75768522
7MP0000465_gastrointestinal_hemorrhage3.74161590
8MP0005083_abnormal_biliary_tract3.67161791
9MP0003698_abnormal_male_reproductive3.58563048
10MP0003724_increased_susceptibility_to3.35321807
11MP0001929_abnormal_gametogenesis3.17667651
12MP0002132_abnormal_respiratory_system3.14809534
13MP0002282_abnormal_trachea_morphology2.60034318
14MP0004133_heterotaxia2.57094147
15MP0003303_peritoneal_inflammation2.48700185
16MP0000343_altered_response_to2.48126127
17MP0009046_muscle_twitch2.31700536
18MP0002160_abnormal_reproductive_system2.29181300
19MP0004084_abnormal_cardiac_muscle2.28667324
20MP0002210_abnormal_sex_determination2.23838189
21MP0005167_abnormal_blood-brain_barrier2.08599317
22MP0005646_abnormal_pituitary_gland2.05982972
23MP0001440_abnormal_grooming_behavior2.03264023
24MP0003566_abnormal_cell_adhesion1.91929011
25MP0003656_abnormal_erythrocyte_physiolo1.90546977
26MP0008877_abnormal_DNA_methylation1.83289756
27MP0002161_abnormal_fertility/fecundity1.82782758
28MP0000230_abnormal_systemic_arterial1.82314711
29MP0001879_abnormal_lymphatic_vessel1.78233284
30MP0004381_abnormal_hair_follicle1.76446429
31MP0002249_abnormal_larynx_morphology1.76132888
32MP0008872_abnormal_physiological_respon1.70665724
33MP0003638_abnormal_response/metabolism_1.68633634
34MP0003828_pulmonary_edema1.68486682
35MP0001145_abnormal_male_reproductive1.67871283
36MP0002928_abnormal_bile_duct1.66663525
37MP0001545_abnormal_hematopoietic_system1.66199093
38MP0005397_hematopoietic_system_phenotyp1.66199093
39MP0004510_myositis1.64096332
40MP0008775_abnormal_heart_ventricle1.62438767
41MP0006054_spinal_hemorrhage1.62005821
42MP0008875_abnormal_xenobiotic_pharmacok1.59696840
43MP0010155_abnormal_intestine_physiology1.57562543
44MP0003879_abnormal_hair_cell1.55260122
45MP0000653_abnormal_sex_gland1.52436616
46MP0001835_abnormal_antigen_presentation1.50979604
47MP0005084_abnormal_gallbladder_morpholo1.49658922
48MP0003950_abnormal_plasma_membrane1.48325350
49MP0009697_abnormal_copulation1.44440431
50MP0005085_abnormal_gallbladder_physiolo1.40957952
51MP0004036_abnormal_muscle_relaxation1.39626289
52MP0009765_abnormal_xenobiotic_induced1.34409366
53MP0002638_abnormal_pupillary_reflex1.34280739
54MP0005647_abnormal_sex_gland1.34267493
55MP0002736_abnormal_nociception_after1.34092134
56MP0001663_abnormal_digestive_system1.33355267
57MP0001984_abnormal_olfaction1.29791756
58MP0003937_abnormal_limbs/digits/tail_de1.27266807
59MP0003806_abnormal_nucleotide_metabolis1.26259874
60MP0001501_abnormal_sleep_pattern1.25057030
61MP0000778_abnormal_nervous_system1.24660810
62MP0003634_abnormal_glial_cell1.23119286
63MP0005365_abnormal_bile_salt1.22435529
64MP0005389_reproductive_system_phenotype1.21485719
65MP0003718_maternal_effect1.21421603
66MP0003690_abnormal_glial_cell1.20656616
67MP0009763_increased_sensitivity_to1.20595294
68MP0004215_abnormal_myocardial_fiber1.19891089
69MP0005670_abnormal_white_adipose1.19553355
70MP0000249_abnormal_blood_vessel1.19003685
71MP0001968_abnormal_touch/_nociception1.18023218
72MP0005551_abnormal_eye_electrophysiolog1.15439260
73MP0000049_abnormal_middle_ear1.14543269
74MP0002148_abnormal_hypersensitivity_rea1.11351804
75MP0004742_abnormal_vestibular_system1.08983587
76MP0003938_abnormal_ear_development1.08913466
77MP0009250_abnormal_appendicular_skeleto1.07268932
78MP0002938_white_spotting1.07267609
79MP0010329_abnormal_lipoprotein_level1.06856423
80MP0005058_abnormal_lysosome_morphology1.05574404
81MP0003186_abnormal_redox_activity1.04189641
82MP0006036_abnormal_mitochondrial_physio1.03035364
83MP0002734_abnormal_mechanical_nocicepti1.03003603
84MP0005388_respiratory_system_phenotype1.02999492
85MP0002133_abnormal_respiratory_system1.02999492
86MP0009780_abnormal_chondrocyte_physiolo1.02667328
87MP0001177_atelectasis1.01562336
88MP0002733_abnormal_thermal_nociception1.01409188
89MP0002398_abnormal_bone_marrow1.01318598
90MP0009745_abnormal_behavioral_response1.00687115
91MP0001664_abnormal_digestion0.99650981
92MP0009764_decreased_sensitivity_to0.99080399
93MP0001485_abnormal_pinna_reflex0.98665362
94MP0009384_cardiac_valve_regurgitation0.97877205
95MP0005379_endocrine/exocrine_gland_phen0.97619561
96MP0004130_abnormal_muscle_cell0.97062076
97MP0000858_altered_metastatic_potential0.96854229
98MP0006292_abnormal_olfactory_placode0.95511890
99MP0005165_increased_susceptibility_to0.95398961
100MP0002102_abnormal_ear_morphology0.94864364
101MP0000428_abnormal_craniofacial_morphol0.93968532
102MP0001970_abnormal_pain_threshold0.93848229
103MP0008874_decreased_physiological_sensi0.93442942
104MP0000383_abnormal_hair_follicle0.92950451
105MP0005671_abnormal_response_to0.92847001
106MP0003011_delayed_dark_adaptation0.91691255
107MP0009642_abnormal_blood_homeostasis0.90923689
108MP0001851_eye_inflammation0.90585402
109MP0006276_abnormal_autonomic_nervous0.90280292
110MP0002557_abnormal_social/conspecific_i0.88604601
111MP0002572_abnormal_emotion/affect_behav0.88569685
112MP0001765_abnormal_ion_homeostasis0.84959689
113MP0002064_seizures0.84933967
114MP0005253_abnormal_eye_physiology0.84933682
115MP0005000_abnormal_immune_tolerance0.83992946
116MP0004147_increased_porphyrin_level0.82528274
117MP0000490_abnormal_crypts_of0.81833652
118MP0001533_abnormal_skeleton_physiology0.81627646
119MP0001270_distended_abdomen0.81414683
120MP0004858_abnormal_nervous_system0.79793465
121MP0002272_abnormal_nervous_system0.79244316
122MP0002909_abnormal_adrenal_gland0.78888072
123MP0000470_abnormal_stomach_morphology0.78684564
124MP0004883_abnormal_blood_vessel0.77868593
125MP0000749_muscle_degeneration0.77013145
126MP0003942_abnormal_urinary_system0.76667734
127MP0000026_abnormal_inner_ear0.76513469
128MP0004085_abnormal_heartbeat0.76279599
129MP0008995_early_reproductive_senescence0.76257504
130MP0002972_abnormal_cardiac_muscle0.75118480
131MP0001905_abnormal_dopamine_level0.74999091
132MP0002152_abnormal_brain_morphology0.74042354
133MP0005636_abnormal_mineral_homeostasis0.73834126
134MP0003861_abnormal_nervous_system0.73757071
135MP0001486_abnormal_startle_reflex0.73507648
136MP0002168_other_aberrant_phenotype0.73272872
137MP0005391_vision/eye_phenotype0.73086658
138MP0003635_abnormal_synaptic_transmissio0.73065774
139MP0005409_darkened_coat_color0.72719183
140MP0005187_abnormal_penis_morphology0.72540468
141MP0004947_skin_inflammation0.72148348
142MP0003646_muscle_fatigue0.71954541
143MP0000631_abnormal_neuroendocrine_gland0.71760187
144MP0000358_abnormal_cell_content/0.71648912
145MP0002735_abnormal_chemical_nociception0.70673585
146MP0002429_abnormal_blood_cell0.70278245
147MP0000689_abnormal_spleen_morphology0.70248673
148MP0000015_abnormal_ear_pigmentation0.69320059
149MP0002118_abnormal_lipid_homeostasis0.68703705
150MP0003633_abnormal_nervous_system0.68124771
151MP0002116_abnormal_craniofacial_bone0.67509436
152MP0003866_abnormal_defecation0.67000019
153MP0003880_abnormal_central_pattern0.66439101
154MP0006138_congestive_heart_failure0.65758864
155MP0005385_cardiovascular_system_phenoty0.65655709
156MP0001544_abnormal_cardiovascular_syste0.65655709
157MP0001963_abnormal_hearing_physiology0.65060361
158MP0005535_abnormal_body_temperature0.64944115
159MP0002128_abnormal_blood_circulation0.64526048
160MP0002722_abnormal_immune_system0.64070562
161MP0003252_abnormal_bile_duct0.63959266
162MP0001849_ear_inflammation0.63917175
163MP0002752_abnormal_somatic_nervous0.63092377
164MP0003436_decreased_susceptibility_to0.63006567
165MP0002063_abnormal_learning/memory/cond0.62893279
166MP0004859_abnormal_synaptic_plasticity0.62198927
167MP0001188_hyperpigmentation0.61905033
168MP0001986_abnormal_taste_sensitivity0.61549979
169MP0002234_abnormal_pharynx_morphology0.61293703
170MP0002109_abnormal_limb_morphology0.60854633
171MP0001845_abnormal_inflammatory_respons0.60847556
172MP0001958_emphysema0.60344439
173MP0003122_maternal_imprinting0.59728382
174MP0002723_abnormal_immune_serum0.59714981
175MP0005171_absent_coat_pigmentation0.59403142
176MP0004019_abnormal_vitamin_homeostasis0.59176886
177MP0004272_abnormal_basement_membrane0.58953180
178MP0000613_abnormal_salivary_gland0.58758626
179MP0001756_abnormal_urination0.58571896
180MP0001727_abnormal_embryo_implantation0.58505993
181MP0004142_abnormal_muscle_tone0.58266613
182MP0002876_abnormal_thyroid_physiology0.57713472
183MP0004484_altered_response_of0.57298867
184MP0005620_abnormal_muscle_contractility0.57176848
185MP0002882_abnormal_neuron_morphology0.57088312
186MP0000462_abnormal_digestive_system0.55968557
187MP0005381_digestive/alimentary_phenotyp0.54759410

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.75319651
2Abnormal respiratory motile cilium morphology (HP:0005938)9.75319651
3Prolonged bleeding time (HP:0003010)8.92229373
4Dynein arm defect of respiratory motile cilia (HP:0012255)8.90389476
5Absent/shortened dynein arms (HP:0200106)8.90389476
6Menorrhagia (HP:0000132)8.05794462
7Increased mean platelet volume (HP:0011877)8.02670835
8Petechiae (HP:0000967)7.60342450
9Chronic bronchitis (HP:0004469)7.59830946
10Abnormal platelet volume (HP:0011876)7.46255468
11Purpura (HP:0000979)6.90580133
12Bronchiectasis (HP:0002110)6.02940592
13Epistaxis (HP:0000421)5.78172518
14Nasal polyposis (HP:0100582)5.26375240
15Gingival bleeding (HP:0000225)4.70704656
16Hyperlipoproteinemia (HP:0010980)4.63654037
17Impaired platelet aggregation (HP:0003540)4.61709490
18Abnormal platelet function (HP:0011869)4.61709490
19Abnormality of the nasal mucosa (HP:0000433)4.33363962
20Recurrent sinusitis (HP:0011108)4.04922414
21Pancreatic fibrosis (HP:0100732)4.01940350
22Infertility (HP:0000789)3.97223155
23Bronchitis (HP:0012387)3.95685429
24True hermaphroditism (HP:0010459)3.84781816
25Poikilocytosis (HP:0004447)3.68461462
26Nephronophthisis (HP:0000090)3.51752476
27Acanthocytosis (HP:0001927)3.46172438
28Spontaneous hematomas (HP:0007420)3.41641204
29Chronic sinusitis (HP:0011109)3.21623684
30Tubulointerstitial nephritis (HP:0001970)3.16880556
31Dyschromatopsia (HP:0007641)3.16543064
32Recurrent otitis media (HP:0000403)2.96664384
33Abnormality of midbrain morphology (HP:0002418)2.94948773
34Molar tooth sign on MRI (HP:0002419)2.94948773
35Abnormality of the heme biosynthetic pathway (HP:0010472)2.91983319
36Medial flaring of the eyebrow (HP:0010747)2.91963039
37Median cleft lip (HP:0000161)2.80642141
38Abnormality of dentin (HP:0010299)2.73155218
39Occipital encephalocele (HP:0002085)2.71025763
40Conjunctival telangiectasia (HP:0000524)2.69977945
41Abnormality of the renal medulla (HP:0100957)2.68267077
42Male infertility (HP:0003251)2.67869362
43Pancreatic cysts (HP:0001737)2.67397225
44Bile duct proliferation (HP:0001408)2.66508459
45Abnormal biliary tract physiology (HP:0012439)2.66508459
46Postaxial foot polydactyly (HP:0001830)2.62928510
47Paralysis (HP:0003470)2.61023015
48Gait imbalance (HP:0002141)2.54739594
49Abnormality of lateral ventricle (HP:0030047)2.52771918
50Cystic liver disease (HP:0006706)2.52204358
51Congenital primary aphakia (HP:0007707)2.51637575
52Increased density of long bones (HP:0006392)2.51561074
53Abnormal pupillary function (HP:0007686)2.50123087
54Congenital hepatic fibrosis (HP:0002612)2.48312518
55Chronic otitis media (HP:0000389)2.45663840
56Supernumerary spleens (HP:0009799)2.45530358
57Upper limb muscle weakness (HP:0003484)2.41441266
58Abnormality of the vasculature of the conjunctiva (HP:0008054)2.40517006
59Bruising susceptibility (HP:0000978)2.37201954
60Aplasia/Hypoplasia of the tongue (HP:0010295)2.33969127
61Abnormality of the common coagulation pathway (HP:0010990)2.33443252
62Nephrogenic diabetes insipidus (HP:0009806)2.20460612
63Chronic hepatic failure (HP:0100626)2.20091596
64Tubular atrophy (HP:0000092)2.19704697
65Fibular hypoplasia (HP:0003038)2.18907489
66Genital tract atresia (HP:0001827)2.13452594
67Abnormality of the dental root (HP:0006486)2.12375840
68Taurodontia (HP:0000679)2.12375840
69Abnormality of permanent molar morphology (HP:0011071)2.12375840
70Tubulointerstitial abnormality (HP:0001969)2.05782244
71Abnormal auditory evoked potentials (HP:0006958)2.02809050
72Polycythemia (HP:0001901)2.01700599
73Abnormality of molar (HP:0011077)2.01216943
74Abnormality of molar morphology (HP:0011070)2.01216943
75Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.8689755
76Abnormal respiratory motile cilium physiology (HP:0012261)12.6305903
77Abnormal ciliary motility (HP:0012262)11.8903623
78Rhinitis (HP:0012384)10.8459477
79Abnormality of abdominal situs (HP:0011620)1.99806392
80Abdominal situs inversus (HP:0003363)1.99806392
81Male pseudohermaphroditism (HP:0000037)1.96898463
82Stage 5 chronic kidney disease (HP:0003774)1.96463564
83Hepatosplenomegaly (HP:0001433)1.94335253
84Abnormality of the dental pulp (HP:0006479)1.93987817
85Vaginal atresia (HP:0000148)1.91075875
86Ventricular fibrillation (HP:0001663)1.85756767
87Facial cleft (HP:0002006)1.83702470
88Poor coordination (HP:0002370)1.82886774
89Anencephaly (HP:0002323)1.82549947
90Papillary thyroid carcinoma (HP:0002895)1.81632066
91Postaxial hand polydactyly (HP:0001162)1.78723163
92Preaxial hand polydactyly (HP:0001177)1.78597099
93Hyperthyroidism (HP:0000836)1.78330741
94Hypophosphatemic rickets (HP:0004912)1.73412453
95Broad distal phalanx of finger (HP:0009836)1.71437102
96Xanthomatosis (HP:0000991)1.68258450
97Dysautonomia (HP:0002459)1.64683873
98Sclerocornea (HP:0000647)1.63353052
99Generalized aminoaciduria (HP:0002909)1.60829213
100Aplasia/Hypoplasia of the lens (HP:0008063)1.60475531
101Joint hemorrhage (HP:0005261)1.59386886
102Central scotoma (HP:0000603)1.58768825
103Sex reversal (HP:0012245)1.58036502
104Abnormal sex determination (HP:0012244)1.58036502
105Atelectasis (HP:0100750)1.57725709
106Abnormal gallbladder physiology (HP:0012438)1.55588539
107Cholecystitis (HP:0001082)1.55588539
108Thyroid-stimulating hormone excess (HP:0002925)1.55517933
109Oculomotor apraxia (HP:0000657)1.55276310
110Tinnitus (HP:0000360)1.55116691
111Abnormal drinking behavior (HP:0030082)1.54417986
112Polydipsia (HP:0001959)1.54417986
113Nausea (HP:0002018)1.54158450
114Abnormality of iron homeostasis (HP:0011031)1.53434671
115Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.53221297
116Recurrent bronchitis (HP:0002837)1.52921751
117Joint swelling (HP:0001386)1.43569202
118Obstructive lung disease (HP:0006536)1.43240316
119Chronic obstructive pulmonary disease (HP:0006510)1.43240316
120Increased IgM level (HP:0003496)1.41948656
121Short nail (HP:0001799)1.39631709
122Back pain (HP:0003418)1.38968308
123Abnormality of transition element cation homeostasis (HP:0011030)1.38293737
1243-Methylglutaconic aciduria (HP:0003535)1.38107948
125Concave nail (HP:0001598)1.37714453
126Neoplasm of head and neck (HP:0012288)1.37619204
127Esophageal neoplasm (HP:0100751)1.37619204
128Muscle fiber splitting (HP:0003555)1.37288344
129Abnormality of the renal cortex (HP:0011035)1.35161704
130Abnormality of macrophages (HP:0004311)1.34128047
131Biliary tract neoplasm (HP:0100574)1.33831527
132Furrowed tongue (HP:0000221)1.32590011
13311 pairs of ribs (HP:0000878)1.32125241
134Aplasia/Hypoplasia of the fibula (HP:0006492)1.31930357
135Neonatal short-limb short stature (HP:0008921)1.31650221
136Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.30652068
137Increased serum ferritin (HP:0003281)1.30614848
138Nephropathy (HP:0000112)1.29749338
139Bifid tongue (HP:0010297)1.29194820
140Myocardial infarction (HP:0001658)1.28591366
141Hypotelorism (HP:0000601)1.27933383
142Arterial thrombosis (HP:0004420)1.26474099
143Abnormal ventriculo-arterial connection (HP:0011563)1.25119059
144Transposition of the great arteries (HP:0001669)1.25119059
145Abnormal connection of the cardiac segments (HP:0011545)1.25119059
146Tubulointerstitial fibrosis (HP:0005576)1.23160013
147Tongue fasciculations (HP:0001308)1.22775048
148Spontaneous abortion (HP:0005268)1.22763037
149Hyperactive renin-angiotensin system (HP:0000841)1.21062265
150Reticulocytosis (HP:0001923)1.20583779
151Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.20504660
152Degeneration of the lateral corticospinal tracts (HP:0002314)1.20504660
153Hypodontia (HP:0000668)1.19661651
154Asplenia (HP:0001746)1.18555337
155Polycystic kidney dysplasia (HP:0000113)1.18114891
156Specific learning disability (HP:0001328)1.15777910
157Decreased central vision (HP:0007663)1.14636744
158Metaphyseal dysplasia (HP:0100255)1.13815767
159Bell-shaped thorax (HP:0001591)1.13610693
160Narrow chest (HP:0000774)1.11748641
161Ectopic anus (HP:0004397)1.11660476
162Short ribs (HP:0000773)1.11121976

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK157.84612454
2PNCK7.53553819
3RIPK44.88915393
4PDK44.83287377
5PDK34.83287377
6EIF2AK14.33322961
7BMX4.27311756
8TEC3.22749758
9PDK23.15248171
10GRK12.65591217
11BTK2.33662891
12MST42.33654352
13MAPKAPK32.33613055
14PTK2B2.18591511
15PRKD32.09914800
16TESK11.99627417
17PIM21.92484398
18STK391.90262047
19ARAF1.85022765
20WEE11.82702425
21ILK1.77618686
22NTRK21.75827230
23GRK61.65583541
24ZAP701.64695644
25CASK1.58244692
26SYK1.53893979
27CSF1R1.52916071
28PIK3CG1.49653491
29CCNB11.45055562
30TAOK31.42219337
31WNK41.39464391
32VRK11.38558453
33MUSK1.38386524
34PLK21.33112541
35CDK31.27083060
36PAK11.25240046
37PAK21.14430212
38PRKCG1.10868689
39STK241.09971812
40LMTK21.09930811
41HCK1.01566636
42TYRO30.99704148
43RAF10.95472484
44EPHA30.95077758
45ERBB20.94647686
46MAPKAPK50.92861402
47TLK10.92011317
48ACVR1B0.90437500
49ICK0.89730099
50TRIM280.86716477
51MATK0.85194710
52IRAK10.84759665
53MAP3K20.84242134
54STK100.83614847
55LYN0.82046273
56NEK60.79609884
57DAPK30.78818034
58BLK0.75512430
59NTRK30.75372052
60BCR0.74376859
61RET0.73979185
62PINK10.68708959
63MYLK0.68574066
64ROCK20.66758902
65BRSK20.66340489
66MAP3K40.63911031
67FER0.62609830
68WNK10.61394497
69PBK0.61243643
70MARK10.60249925
71ROCK10.60230258
72TNK20.60081232
73GSK3A0.59385971
74MAP3K50.58627802
75DAPK20.58150602
76ZAK0.57212648
77PRKD10.56686851
78PRKG10.56573243
79BMPR1B0.55793332
80MAP3K30.55034564
81PRKCE0.53743476
82CAMK2A0.53373616
83IKBKB0.52940659
84MAP2K30.51624295
85MAP2K70.50773605
86ADRBK20.49925411
87STK40.49775553
88CDC42BPA0.48827487
89SIK30.48362663
90NLK0.48199833
91MAPK120.47993248
92BMPR20.47173634
93RPS6KA20.46355603
94TRPM70.45775617
95OXSR10.45215651
96AURKA0.44792279
97MARK30.43594637
98MAP2K10.41920402
99TAOK20.40975697
100MAP2K20.40578319
101PRKACA0.39832887
102IRAK20.39651566
103FES0.38964478
104CAMK1G0.37437023
105GRK50.36519241
106MAP4K20.36497556
107PRKG20.35979611
108PRKCQ0.35963591
109DMPK0.35204525
110PDK10.34947542
111EPHA40.34278229
112PDGFRB0.34226547
113BRAF0.34216915
114JAK20.32651726
115TXK0.32500244
116PRKACG0.32307572
117SIK10.32293950
118NUAK10.32191220
119DYRK20.32056213
120EPHB20.32019286
121SRC0.30086324
122MAPK130.29738340
123FGR0.29324418
124ITK0.29309856
125ADRBK10.29208126
126MAPK70.29076025
127RPS6KA50.28896873
128FYN0.28026534
129PRKCD0.28016685
130STK30.27881359
131PRKCB0.27151582
132PKN10.26938084
133STK380.26063286
134PHKG20.25818553
135PHKG10.25818553
136CAMKK10.25506927
137STK110.25106712
138PLK30.25046329
139PTK20.25017806
140IGF1R0.24367907
141PRKDC0.24357725
142PIM10.24146489
143CSNK1E0.23864056
144DYRK1A0.23115259
145EEF2K0.23065771
146PAK30.23061887
147MAP2K60.22970607
148MAPK100.21930113
149TAOK10.20995861
150ABL10.20360289
151PRKCA0.20347961
152DYRK30.20303826
153MAPKAPK20.20207280
154CAMK2B0.19797410
155YES10.19787009
156MINK10.19592702
157DDR20.19547621
158PRKAA20.18971563
159TNIK0.18713913
160CSK0.18567175
161ERBB30.18000257
162WNK30.17644584
163CDK50.16594559

Predicted pathways (KEGG)

RankGene SetZ-score
1Platelet activation_Homo sapiens_hsa046115.27446776
2Vitamin B6 metabolism_Homo sapiens_hsa007504.58461709
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.94812580
4Huntingtons disease_Homo sapiens_hsa050163.72893434
5Pathogenic Escherichia coli infection_Homo sapiens_hsa051303.71071036
6SNARE interactions in vesicular transport_Homo sapiens_hsa041303.08344327
7Nitrogen metabolism_Homo sapiens_hsa009102.64229708
8Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.45819753
9Hematopoietic cell lineage_Homo sapiens_hsa046402.22222999
10Pyruvate metabolism_Homo sapiens_hsa006202.11211901
11PPAR signaling pathway_Homo sapiens_hsa033202.08494034
12Ether lipid metabolism_Homo sapiens_hsa005652.08104151
13Propanoate metabolism_Homo sapiens_hsa006402.01424028
14Gap junction_Homo sapiens_hsa045401.96876514
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.91355210
16Amphetamine addiction_Homo sapiens_hsa050311.83380481
17Nicotine addiction_Homo sapiens_hsa050331.75308847
18Linoleic acid metabolism_Homo sapiens_hsa005911.74159775
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.68794206
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.63727329
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.62194981
22beta-Alanine metabolism_Homo sapiens_hsa004101.56087908
23Chemokine signaling pathway_Homo sapiens_hsa040621.55757106
24Cardiac muscle contraction_Homo sapiens_hsa042601.52491232
25Oxidative phosphorylation_Homo sapiens_hsa001901.47771691
26Phototransduction_Homo sapiens_hsa047441.47231002
27Alcoholism_Homo sapiens_hsa050341.45758625
28Mineral absorption_Homo sapiens_hsa049781.45025116
29Butanoate metabolism_Homo sapiens_hsa006501.42557667
30Systemic lupus erythematosus_Homo sapiens_hsa053221.41793907
31Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.41566446
32Fatty acid biosynthesis_Homo sapiens_hsa000611.38470019
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.37886683
34Hedgehog signaling pathway_Homo sapiens_hsa043401.34877098
35Gastric acid secretion_Homo sapiens_hsa049711.30704928
36Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.29918074
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.29028608
38Dorso-ventral axis formation_Homo sapiens_hsa043201.28119928
39Glutathione metabolism_Homo sapiens_hsa004801.26168613
40Olfactory transduction_Homo sapiens_hsa047401.24590256
41Renin secretion_Homo sapiens_hsa049241.24327606
42Collecting duct acid secretion_Homo sapiens_hsa049661.23552675
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.19754791
44Arachidonic acid metabolism_Homo sapiens_hsa005901.17992945
45Tyrosine metabolism_Homo sapiens_hsa003501.17870934
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.17768712
47Calcium signaling pathway_Homo sapiens_hsa040201.15776562
48Leukocyte transendothelial migration_Homo sapiens_hsa046701.15453443
49Alzheimers disease_Homo sapiens_hsa050101.15305875
50Glycerolipid metabolism_Homo sapiens_hsa005611.14414647
51Glutamatergic synapse_Homo sapiens_hsa047241.13301253
52Ovarian steroidogenesis_Homo sapiens_hsa049131.12377287
53Glucagon signaling pathway_Homo sapiens_hsa049221.10977919
54Endocytosis_Homo sapiens_hsa041441.09631731
55Long-term depression_Homo sapiens_hsa047301.08300926
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.07469151
57Steroid hormone biosynthesis_Homo sapiens_hsa001401.07434770
58Retinol metabolism_Homo sapiens_hsa008301.06598545
59Circadian entrainment_Homo sapiens_hsa047131.04739427
60Glycerophospholipid metabolism_Homo sapiens_hsa005641.03502138
61Purine metabolism_Homo sapiens_hsa002301.03498944
62GABAergic synapse_Homo sapiens_hsa047271.02435582
63Regulation of actin cytoskeleton_Homo sapiens_hsa048101.01398375
64Taste transduction_Homo sapiens_hsa047421.01299931
65Mismatch repair_Homo sapiens_hsa034300.97623298
66Insulin secretion_Homo sapiens_hsa049110.97173089
67Parkinsons disease_Homo sapiens_hsa050120.96532015
68Histidine metabolism_Homo sapiens_hsa003400.95713977
69Cocaine addiction_Homo sapiens_hsa050300.94954855
70Wnt signaling pathway_Homo sapiens_hsa043100.94519715
71Malaria_Homo sapiens_hsa051440.94113145
72Basal cell carcinoma_Homo sapiens_hsa052170.92175116
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91031030
74Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.91007276
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.91001079
76Shigellosis_Homo sapiens_hsa051310.90884916
77Estrogen signaling pathway_Homo sapiens_hsa049150.89236547
78Chemical carcinogenesis_Homo sapiens_hsa052040.88841795
79Basal transcription factors_Homo sapiens_hsa030220.88574956
80Salivary secretion_Homo sapiens_hsa049700.84915996
81Choline metabolism in cancer_Homo sapiens_hsa052310.84219495
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81815467
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81765934
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81089749
85ABC transporters_Homo sapiens_hsa020100.80381728
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.80032923
87cAMP signaling pathway_Homo sapiens_hsa040240.79176729
88Fatty acid elongation_Homo sapiens_hsa000620.77721908
89Circadian rhythm_Homo sapiens_hsa047100.77531034
90Morphine addiction_Homo sapiens_hsa050320.76852866
91Focal adhesion_Homo sapiens_hsa045100.75520616
92Thyroid hormone synthesis_Homo sapiens_hsa049180.74902284
93Starch and sucrose metabolism_Homo sapiens_hsa005000.74824216
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.74455731
95Pancreatic cancer_Homo sapiens_hsa052120.73904940
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.73287776
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71238039
98Sphingolipid metabolism_Homo sapiens_hsa006000.71025903
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70727545
100Fanconi anemia pathway_Homo sapiens_hsa034600.68044528
101B cell receptor signaling pathway_Homo sapiens_hsa046620.67721896
102Rap1 signaling pathway_Homo sapiens_hsa040150.67386917
103Antigen processing and presentation_Homo sapiens_hsa046120.66468312
104Dopaminergic synapse_Homo sapiens_hsa047280.64597977
105Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63397815
106Sulfur metabolism_Homo sapiens_hsa009200.60480523
107Hippo signaling pathway_Homo sapiens_hsa043900.59730475
108Nucleotide excision repair_Homo sapiens_hsa034200.58900538
109Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58808166
110Protein digestion and absorption_Homo sapiens_hsa049740.56529258
111Dilated cardiomyopathy_Homo sapiens_hsa054140.55698376
112Endometrial cancer_Homo sapiens_hsa052130.55324345
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55251480
114Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54976164
115Viral carcinogenesis_Homo sapiens_hsa052030.54568644
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53031711
117Rheumatoid arthritis_Homo sapiens_hsa053230.52556825
118Pancreatic secretion_Homo sapiens_hsa049720.52554467
119Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52424308
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52232621
121Long-term potentiation_Homo sapiens_hsa047200.52046517
122Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51000851
123Arginine and proline metabolism_Homo sapiens_hsa003300.50215671
124Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49168132
125Oxytocin signaling pathway_Homo sapiens_hsa049210.48746085
126Oocyte meiosis_Homo sapiens_hsa041140.48714938
127Glycosaminoglycan degradation_Homo sapiens_hsa005310.48280747
128Ras signaling pathway_Homo sapiens_hsa040140.47783532
129Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.47544088
130Serotonergic synapse_Homo sapiens_hsa047260.46795266
131Synaptic vesicle cycle_Homo sapiens_hsa047210.46629588
132T cell receptor signaling pathway_Homo sapiens_hsa046600.46521641
133Melanogenesis_Homo sapiens_hsa049160.46519344
134Adherens junction_Homo sapiens_hsa045200.46470982
135Metabolic pathways_Homo sapiens_hsa011000.45270946
136Bile secretion_Homo sapiens_hsa049760.44613855
137Prion diseases_Homo sapiens_hsa050200.44590410
138Steroid biosynthesis_Homo sapiens_hsa001000.44508003
139Caffeine metabolism_Homo sapiens_hsa002320.44480249
140Melanoma_Homo sapiens_hsa052180.43913244
141Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43881376
142Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.43082406
143Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43058553
144Phagosome_Homo sapiens_hsa041450.42949890
145Renin-angiotensin system_Homo sapiens_hsa046140.41881663
146Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41588723
147Non-small cell lung cancer_Homo sapiens_hsa052230.41062695
148Complement and coagulation cascades_Homo sapiens_hsa046100.39788412
149Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39478146
150Amoebiasis_Homo sapiens_hsa051460.37942455
151Axon guidance_Homo sapiens_hsa043600.37556533
152Pentose phosphate pathway_Homo sapiens_hsa000300.36050340
153Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36030991
154GnRH signaling pathway_Homo sapiens_hsa049120.35169743
155ECM-receptor interaction_Homo sapiens_hsa045120.35111139
156Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34224379
157Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33399013
158VEGF signaling pathway_Homo sapiens_hsa043700.32951851
159Tight junction_Homo sapiens_hsa045300.31958079
160Notch signaling pathway_Homo sapiens_hsa043300.29011063
161Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.28717315

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