CFAP221

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.82188019
2cell wall macromolecule catabolic process (GO:0016998)9.49165449
3cell wall macromolecule metabolic process (GO:0044036)9.49165449
4ventricular system development (GO:0021591)9.12924743
5multicellular organism reproduction (GO:0032504)9.07160120
6sperm motility (GO:0030317)9.05090517
7axoneme assembly (GO:0035082)8.87338429
8acrosome assembly (GO:0001675)8.78151320
9plasma membrane fusion (GO:0045026)8.20668577
10sperm-egg recognition (GO:0035036)8.13559440
11GTP biosynthetic process (GO:0006183)8.06563830
12acrosome reaction (GO:0007340)7.62909033
13piRNA metabolic process (GO:0034587)7.30116722
14reproduction (GO:0000003)7.27054333
15cell-cell recognition (GO:0009988)7.22992663
16UTP biosynthetic process (GO:0006228)7.19912792
17regulation of cilium movement (GO:0003352)7.18607113
18binding of sperm to zona pellucida (GO:0007339)7.09656223
19spermatid development (GO:0007286)7.01376085
20left/right axis specification (GO:0070986)6.99830133
21UTP metabolic process (GO:0046051)6.68069907
22nucleoside diphosphate phosphorylation (GO:0006165)6.66676649
23male meiosis (GO:0007140)6.26055628
24single fertilization (GO:0007338)6.26027059
25intraciliary transport (GO:0042073)5.77193708
26synaptonemal complex organization (GO:0070193)5.74740704
27negative regulation of inclusion body assembly (GO:0090084)5.43052423
28CTP metabolic process (GO:0046036)5.37656465
29CTP biosynthetic process (GO:0006241)5.37656465
30guanosine-containing compound biosynthetic process (GO:1901070)5.31512493
31fertilization (GO:0009566)5.27519629
32cilium organization (GO:0044782)5.17477440
33pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)4.92039528
34synaptonemal complex assembly (GO:0007130)4.90403216
35microtubule severing (GO:0051013)4.88014446
36cilium morphogenesis (GO:0060271)4.82588391
37cilium assembly (GO:0042384)4.82161295
38spermatid nucleus differentiation (GO:0007289)4.72391446
39spermatogenesis (GO:0007283)4.71749449
40sperm capacitation (GO:0048240)4.69659664
41male gamete generation (GO:0048232)4.69566266
42pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)4.67399443
43DNA methylation involved in gamete generation (GO:0043046)4.55796950
44microtubule-based movement (GO:0007018)4.54593858
45microtubule bundle formation (GO:0001578)4.50114810
46meiotic cell cycle (GO:0051321)4.46080665
47pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)4.45962890
48protein localization to cilium (GO:0061512)4.42140432
49gamete generation (GO:0007276)4.37852800
50cellular component assembly involved in morphogenesis (GO:0010927)4.35992831
51regulation of inclusion body assembly (GO:0090083)4.27289755
52male meiosis I (GO:0007141)4.17904971
53regulation of microtubule-based movement (GO:0060632)4.14891578
54germ cell development (GO:0007281)3.96903108
55left/right pattern formation (GO:0060972)3.96137453
56pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.95699941
57cellular process involved in reproduction in multicellular organism (GO:0022412)3.90183418
58calcium ion-dependent exocytosis (GO:0017156)3.89900520
59organic cation transport (GO:0015695)3.84287962
60microtubule depolymerization (GO:0007019)3.79630146
61cell recognition (GO:0008037)3.74258908
62photoreceptor cell maintenance (GO:0045494)3.67903974
63retinal cone cell development (GO:0046549)3.63315850
64centriole replication (GO:0007099)3.62690669
65nucleotide phosphorylation (GO:0046939)3.62455972
66protein polyglutamylation (GO:0018095)3.55380154
67centriole assembly (GO:0098534)3.54916339
68multicellular organismal reproductive process (GO:0048609)3.46691314
69response to pheromone (GO:0019236)3.42925442
70meiotic nuclear division (GO:0007126)3.38056164
71meiosis I (GO:0007127)3.37914994
72nucleoside diphosphate metabolic process (GO:0009132)3.29913074
73exogenous drug catabolic process (GO:0042738)3.28770556
74cell projection assembly (GO:0030031)3.24193953
75chromosome organization involved in meiosis (GO:0070192)3.23134993
76cellular ketone body metabolic process (GO:0046950)3.15458729
77behavioral response to nicotine (GO:0035095)3.13829637
78L-fucose catabolic process (GO:0042355)3.11208182
79fucose catabolic process (GO:0019317)3.11208182
80L-fucose metabolic process (GO:0042354)3.11208182
81indole-containing compound catabolic process (GO:0042436)3.09337131
82indolalkylamine catabolic process (GO:0046218)3.09337131
83tryptophan catabolic process (GO:0006569)3.09337131
84drug catabolic process (GO:0042737)3.08343231
85pyrimidine ribonucleoside biosynthetic process (GO:0046132)3.07648903
86regulation of centriole replication (GO:0046599)3.06306942
87chaperone-mediated protein complex assembly (GO:0051131)3.03692157
88regulation of meiosis I (GO:0060631)2.97525403
89pyrimidine ribonucleotide biosynthetic process (GO:0009220)2.94371798
90primary alcohol catabolic process (GO:0034310)2.93466350
91diterpenoid biosynthetic process (GO:0016102)2.91691127
92benzene-containing compound metabolic process (GO:0042537)2.90687178
93detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.89039807
94detection of light stimulus involved in visual perception (GO:0050908)2.88170838
95detection of light stimulus involved in sensory perception (GO:0050962)2.88170838
96vitamin transmembrane transport (GO:0035461)2.87067737
97indolalkylamine metabolic process (GO:0006586)2.86701819
98ketone body metabolic process (GO:1902224)2.85818172
99rRNA catabolic process (GO:0016075)2.85283277
100lateral ventricle development (GO:0021670)2.85229095
101retinal rod cell development (GO:0046548)2.79355933
102pyrimidine ribonucleotide metabolic process (GO:0009218)2.77367387
103nonmotile primary cilium assembly (GO:0035058)2.77210841
104cornea development in camera-type eye (GO:0061303)2.75410646
105negative regulation of cytosolic calcium ion concentration (GO:0051481)2.75191933
106retinoic acid metabolic process (GO:0042573)2.74669179
107negative regulation of T cell differentiation in thymus (GO:0033085)2.72705312
108neural tube formation (GO:0001841)2.71910127
109response to xenobiotic stimulus (GO:0009410)2.69831578
110thyroid hormone metabolic process (GO:0042403)2.69340075
111one-carbon compound transport (GO:0019755)2.68212207
112microtubule polymerization or depolymerization (GO:0031109)2.67570915
113kynurenine metabolic process (GO:0070189)2.67499024
114specification of symmetry (GO:0009799)2.63606843
115microtubule-based process (GO:0007017)2.62843596
116regulation of collateral sprouting (GO:0048670)2.62759790
117ethanol metabolic process (GO:0006067)2.61975869
118photoreceptor cell development (GO:0042461)2.61526937
119behavioral response to ethanol (GO:0048149)2.60668911
120protein refolding (GO:0042026)2.58929879
121organelle assembly (GO:0070925)2.58628332
122purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.56860248
123spinal cord motor neuron differentiation (GO:0021522)2.56847644
124tryptophan metabolic process (GO:0006568)2.55324952
125seminiferous tubule development (GO:0072520)2.55049807
126negative regulation of mast cell activation (GO:0033004)2.54804001
127multicellular organismal development (GO:0007275)2.50446219
128negative regulation of organelle assembly (GO:1902116)2.49380239
129protein K11-linked deubiquitination (GO:0035871)2.49196787
130purine nucleoside triphosphate biosynthetic process (GO:0009145)2.49141908
131smoothened signaling pathway (GO:0007224)2.48740863
132terpenoid biosynthetic process (GO:0016114)2.46900474
133platelet dense granule organization (GO:0060155)2.46163829
134gene silencing by RNA (GO:0031047)2.45683465
135C21-steroid hormone biosynthetic process (GO:0006700)2.44808090
136determination of left/right symmetry (GO:0007368)2.44667890
137adaptation of signaling pathway (GO:0023058)2.44311137
138pyrimidine nucleotide biosynthetic process (GO:0006221)2.43838030
139negative regulation of telomere maintenance (GO:0032205)2.41696731
140glutathione derivative biosynthetic process (GO:1901687)2.39485205
141glutathione derivative metabolic process (GO:1901685)2.39485205
142pyrimidine ribonucleoside metabolic process (GO:0046131)2.39450533
143lung epithelium development (GO:0060428)2.38372255
144gamma-aminobutyric acid transport (GO:0015812)2.38348243
145establishment of protein localization to Golgi (GO:0072600)2.36743492
146determination of bilateral symmetry (GO:0009855)2.35994256
147eye photoreceptor cell development (GO:0042462)2.33781919
148G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.33624138
149pyrimidine-containing compound transmembrane transport (GO:0072531)2.31957966
150cellular biogenic amine catabolic process (GO:0042402)2.30618897
151amine catabolic process (GO:0009310)2.30618897
152sulfation (GO:0051923)2.29842758
153water-soluble vitamin biosynthetic process (GO:0042364)2.29704291
154aldehyde catabolic process (GO:0046185)2.29252655
155neurotransmitter metabolic process (GO:0042133)2.28784311
156positive regulation of oligodendrocyte differentiation (GO:0048714)2.28455598
157cilium or flagellum-dependent cell motility (GO:0001539)16.7581669
158axonemal dynein complex assembly (GO:0070286)14.6668477
159cilium movement (GO:0003341)14.1167185
160epithelial cilium movement (GO:0003351)11.8872500
161motile cilium assembly (GO:0044458)11.1061356
162fusion of sperm to egg plasma membrane (GO:0007342)10.7441199

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.90403043
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.19564948
3EZH2_22144423_ChIP-Seq_EOC_Human4.25629401
4GBX2_23144817_ChIP-Seq_PC3_Human2.85359374
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.82208844
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.59109446
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.45733122
8PCGF2_27294783_Chip-Seq_ESCs_Mouse2.18771568
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.16057975
10IGF1R_20145208_ChIP-Seq_DFB_Human2.03137501
11PIAS1_25552417_ChIP-Seq_VCAP_Human1.94493046
12P300_19829295_ChIP-Seq_ESCs_Human1.92536462
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.89266470
14CBX2_27304074_Chip-Seq_ESCs_Mouse1.88612789
15EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.81589439
16PCGF2_27294783_Chip-Seq_NPCs_Mouse1.80998958
17SUZ12_27294783_Chip-Seq_NPCs_Mouse1.80043028
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.79083417
19KAP1_22055183_ChIP-Seq_ESCs_Mouse1.78922656
20CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78787018
21GATA1_26923725_Chip-Seq_HPCs_Mouse1.75594648
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.74275845
23TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.71090737
24EWS_26573619_Chip-Seq_HEK293_Human1.70626285
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.69958165
26DROSHA_22980978_ChIP-Seq_HELA_Human1.69620543
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.68915810
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65499625
29NFE2_27457419_Chip-Seq_LIVER_Mouse1.65461829
30WDR5_24793694_ChIP-Seq_LNCAP_Human1.65387964
31TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.62985743
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.60155781
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.57160051
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57036475
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55513303
36AR_25329375_ChIP-Seq_VCAP_Human1.53080760
37MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.53078532
38TAL1_26923725_Chip-Seq_HPCs_Mouse1.52400046
39TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52259086
40ZNF274_21170338_ChIP-Seq_K562_Hela1.51939288
41RBPJ_22232070_ChIP-Seq_NCS_Mouse1.49583995
42AR_21572438_ChIP-Seq_LNCaP_Human1.49253455
43RNF2_27304074_Chip-Seq_NSC_Mouse1.47183830
44VDR_22108803_ChIP-Seq_LS180_Human1.47021333
45FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.46283982
46ELK4_26923725_Chip-Seq_MESODERM_Mouse1.46221513
47KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.44884859
48TCF4_22108803_ChIP-Seq_LS180_Human1.44523112
49UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44100419
50BCAT_22108803_ChIP-Seq_LS180_Human1.43421717
51CBP_20019798_ChIP-Seq_JUKART_Human1.42250991
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42250991
53NANOG_18555785_Chip-Seq_ESCs_Mouse1.41250115
54ER_23166858_ChIP-Seq_MCF-7_Human1.40875283
55SMAD4_21799915_ChIP-Seq_A2780_Human1.39449364
56EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.38846887
57ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.35287403
58KDM2B_26808549_Chip-Seq_REH_Human1.35050092
59TAF15_26573619_Chip-Seq_HEK293_Human1.34306752
60EZH2_27294783_Chip-Seq_NPCs_Mouse1.34249368
61REST_21632747_ChIP-Seq_MESCs_Mouse1.30870611
62CRX_20693478_ChIP-Seq_RETINA_Mouse1.30656759
63RUNX2_22187159_ChIP-Seq_PCA_Human1.30516266
64NANOG_19829295_ChIP-Seq_ESCs_Human1.29956932
65SOX2_19829295_ChIP-Seq_ESCs_Human1.29956932
66FLI1_21867929_ChIP-Seq_TH2_Mouse1.29101915
67OCT4_18555785_Chip-Seq_ESCs_Mouse1.29029987
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28863129
69FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28033324
70FOXA1_25329375_ChIP-Seq_VCAP_Human1.28033324
71FUS_26573619_Chip-Seq_HEK293_Human1.27782759
72KLF5_20875108_ChIP-Seq_MESCs_Mouse1.27755879
73CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27594266
74P53_22387025_ChIP-Seq_ESCs_Mouse1.27501676
75BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26698990
76RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.25950145
77SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.25912907
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.25409099
79CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23483391
80TP53_22573176_ChIP-Seq_HFKS_Human1.22689618
81CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.22367887
82SOX2_22085726_ChIP-Seq_NPCs_Mouse1.22138476
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21914561
84PRDM14_20953172_ChIP-Seq_ESCs_Human1.21622825
85CMYC_18555785_Chip-Seq_ESCs_Mouse1.21252094
86STAT1_17558387_ChIP-Seq_HELA_Human1.20768551
87STAT3_18555785_Chip-Seq_ESCs_Mouse1.20526408
88EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.19853628
89SMAD4_21741376_ChIP-Seq_EPCs_Human1.19028088
90FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17357631
91SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17320879
92AHR_22903824_ChIP-Seq_MCF-7_Human1.17149537
93CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.16646609
94FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16490750
95P300_18555785_Chip-Seq_ESCs_Mouse1.16238318
96OCT4_21477851_ChIP-Seq_ESCs_Mouse1.15756515
97GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.15691656
98ESRRB_18555785_Chip-Seq_ESCs_Mouse1.15533226
99GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14989283
100CDX2_22108803_ChIP-Seq_LS180_Human1.14361126
101ETV1_20927104_ChIP-Seq_GIST48_Human1.13802076
102MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12568936
103E2F1_18555785_Chip-Seq_ESCs_Mouse1.12530817
104TP53_16413492_ChIP-PET_HCT116_Human1.12349794
105AR_20517297_ChIP-Seq_VCAP_Human1.12193074
106SUZ12_18555785_Chip-Seq_ESCs_Mouse1.11871317
107SOX2_18555785_Chip-Seq_ESCs_Mouse1.11860572
108AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10995340
109LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.10384330
110GATA3_21878914_ChIP-Seq_MCF-7_Human1.10292338
111NCOR_22424771_ChIP-Seq_293T_Human1.10210928
112ZFX_18555785_Chip-Seq_ESCs_Mouse1.09993718
113PHF8_20622853_ChIP-Seq_HELA_Human1.07925743
114PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.07736199
115KLF4_18555785_Chip-Seq_ESCs_Mouse1.07310901
116PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.07239554
117TBL1_22424771_ChIP-Seq_293T_Human1.06978098
118CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06621005
119NFYB_21822215_ChIP-Seq_K562_Human1.06521806
120OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05337846
121TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03899319
122POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03899319
123POU3F2_20337985_ChIP-ChIP_501MEL_Human1.03831608
124TCF4_23295773_ChIP-Seq_U87_Human1.03544487
125P53_21459846_ChIP-Seq_SAOS-2_Human1.03446235
126EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03328934
127PU1_27457419_Chip-Seq_LIVER_Mouse1.02539478
128HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.02458374
129SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.02244096
130TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02023282
131ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02005620
132TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01150909
133GF1_26923725_Chip-Seq_HPCs_Mouse1.00669849
134AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00092041
135GF1B_26923725_Chip-Seq_HPCs_Mouse0.99012728
136RUNX1_27457419_Chip-Seq_LIVER_Mouse0.98600874
137RBPJ_21746931_ChIP-Seq_IB4_Human0.98592551
138LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98434736
139SMAD3_21741376_ChIP-Seq_EPCs_Human0.98419179
140HOXB7_26014856_ChIP-Seq_BT474_Human0.98018965
141CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97795944
142MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.97511187
143STAT3_23295773_ChIP-Seq_U87_Human0.96649198
144EZH2_27294783_Chip-Seq_ESCs_Mouse0.96376619
145NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96269776
146CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95975222
147PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95624480
148GATA3_21867929_ChIP-Seq_CD8_Mouse0.95469012

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology4.94923859
2MP0003698_abnormal_male_reproductive4.81245226
3MP0001929_abnormal_gametogenesis4.43778046
4MP0005623_abnormal_meninges_morphology4.43249733
5MP0008877_abnormal_DNA_methylation3.92469229
6MP0008875_abnormal_xenobiotic_pharmacok3.80816251
7MP0003136_yellow_coat_color3.80666212
8MP0008004_abnormal_stomach_pH3.37690502
9MP0002210_abnormal_sex_determination3.09911717
10MP0004043_abnormal_pH_regulation2.80724151
11MP0002161_abnormal_fertility/fecundity2.64683531
12MP0003195_calcinosis2.62212169
13MP0002160_abnormal_reproductive_system2.45329230
14MP0001145_abnormal_male_reproductive2.44782119
15MP0002282_abnormal_trachea_morphology2.29624894
16MP0000653_abnormal_sex_gland2.26555057
17MP0002277_abnormal_respiratory_mucosa2.19716693
18MP0002876_abnormal_thyroid_physiology2.04993605
19MP0002132_abnormal_respiratory_system2.01514868
20MP0005410_abnormal_fertilization11.2946229
21MP0002928_abnormal_bile_duct1.99511088
22MP0002102_abnormal_ear_morphology1.93966076
23MP0005670_abnormal_white_adipose1.92901021
24MP0009046_muscle_twitch1.85458820
25MP0005647_abnormal_sex_gland1.79363856
26MP0001440_abnormal_grooming_behavior1.78493309
27MP0000383_abnormal_hair_follicle1.78117118
28MP0005645_abnormal_hypothalamus_physiol1.76475078
29MP0005646_abnormal_pituitary_gland1.76232573
30MP0001485_abnormal_pinna_reflex1.75512514
31MP0004133_heterotaxia1.69940790
32MP0008872_abnormal_physiological_respon1.68995485
33MP0001486_abnormal_startle_reflex1.57701728
34MP0000569_abnormal_digit_pigmentation1.57153267
35MP0004142_abnormal_muscle_tone1.51761260
36MP0001984_abnormal_olfaction1.49998002
37MP0006072_abnormal_retinal_apoptosis1.37834754
38MP0009780_abnormal_chondrocyte_physiolo1.37366965
39MP0004885_abnormal_endolymph1.34487604
40MP0002837_dystrophic_cardiac_calcinosis1.33572752
41MP0002736_abnormal_nociception_after1.31414482
42MP0005389_reproductive_system_phenotype1.30389372
43MP0000427_abnormal_hair_cycle1.29942600
44MP0001968_abnormal_touch/_nociception1.27756684
45MP0001986_abnormal_taste_sensitivity1.27598004
46MP0004147_increased_porphyrin_level1.26624193
47MP0002938_white_spotting1.22235338
48MP0001970_abnormal_pain_threshold1.20070152
49MP0000372_irregular_coat_pigmentation1.19540626
50MP0003950_abnormal_plasma_membrane1.18017605
51MP0003646_muscle_fatigue1.16435826
52MP0005084_abnormal_gallbladder_morpholo1.15081251
53MP0002163_abnormal_gland_morphology1.13708221
54MP0003787_abnormal_imprinting1.11266123
55MP0010386_abnormal_urinary_bladder1.08765714
56MP0004019_abnormal_vitamin_homeostasis1.08691934
57MP0005195_abnormal_posterior_eye1.07304822
58MP0010678_abnormal_skin_adnexa1.05980902
59MP0002909_abnormal_adrenal_gland1.03414775
60MP0005174_abnormal_tail_pigmentation1.02557303
61MP0004233_abnormal_muscle_weight1.02395127
62MP0001501_abnormal_sleep_pattern1.02196061
63MP0005085_abnormal_gallbladder_physiolo1.01685263
64MP0001324_abnormal_eye_pigmentation1.01443691
65MP0005551_abnormal_eye_electrophysiolog1.00730903
66MP0005379_endocrine/exocrine_gland_phen1.00304894
67MP0002249_abnormal_larynx_morphology0.99192518
68MP0000566_synostosis0.98876094
69MP0002229_neurodegeneration0.96725211
70MP0005083_abnormal_biliary_tract0.91927259
71MP0003252_abnormal_bile_duct0.91172896
72MP0001851_eye_inflammation0.90775208
73MP0004381_abnormal_hair_follicle0.90178677
74MP0008995_early_reproductive_senescence0.89089685
75MP0002734_abnormal_mechanical_nocicepti0.88379067
76MP0004270_analgesia0.86648925
77MP0002733_abnormal_thermal_nociception0.85779627
78MP0002133_abnormal_respiratory_system0.85706660
79MP0005388_respiratory_system_phenotype0.85706660
80MP0001529_abnormal_vocalization0.85572650
81MP0005636_abnormal_mineral_homeostasis0.85501529
82MP0001765_abnormal_ion_homeostasis0.84139380
83MP0003283_abnormal_digestive_organ0.83127381
84MP0005365_abnormal_bile_salt0.81989322
85MP0005310_abnormal_salivary_gland0.81631363
86MP0002557_abnormal_social/conspecific_i0.80862907
87MP0001756_abnormal_urination0.79801892
88MP0002138_abnormal_hepatobiliary_system0.77551907
89MP0001944_abnormal_pancreas_morphology0.77535745
90MP0003937_abnormal_limbs/digits/tail_de0.77509207
91MP0004215_abnormal_myocardial_fiber0.77352548
92MP0004085_abnormal_heartbeat0.77114175
93MP0002572_abnormal_emotion/affect_behav0.75893214
94MP0006276_abnormal_autonomic_nervous0.73257559
95MP0000778_abnormal_nervous_system0.72329546
96MP0009745_abnormal_behavioral_response0.71766799
97MP0003942_abnormal_urinary_system0.69454450
98MP0003880_abnormal_central_pattern0.69292438
99MP0002735_abnormal_chemical_nociception0.69084037
100MP0008057_abnormal_DNA_replication0.67087435
101MP0002152_abnormal_brain_morphology0.66485440
102MP0002234_abnormal_pharynx_morphology0.65223069
103MP0002638_abnormal_pupillary_reflex0.64974335
104MP0000026_abnormal_inner_ear0.64007211
105MP0005377_hearing/vestibular/ear_phenot0.63819937
106MP0003878_abnormal_ear_physiology0.63819937
107MP0001502_abnormal_circadian_rhythm0.62954329
108MP0004145_abnormal_muscle_electrophysio0.62666570
109MP0003635_abnormal_synaptic_transmissio0.62018596
110MP0002971_abnormal_brown_adipose0.61766752
111MP0003861_abnormal_nervous_system0.60810212
112MP0003011_delayed_dark_adaptation0.60458272
113MP0002168_other_aberrant_phenotype0.57266871
114MP0009384_cardiac_valve_regurgitation0.56972085
115MP0009115_abnormal_fat_cell0.55099258
116MP0008789_abnormal_olfactory_epithelium0.54551407
117MP0005253_abnormal_eye_physiology0.54196360
118MP0005395_other_phenotype0.52221468
119MP0002752_abnormal_somatic_nervous0.51570634
120MP0003718_maternal_effect0.50813939
121MP0004811_abnormal_neuron_physiology0.50707787
122MP0001905_abnormal_dopamine_level0.50580435
123MP0005499_abnormal_olfactory_system0.49838141
124MP0005394_taste/olfaction_phenotype0.49838141
125MP0000049_abnormal_middle_ear0.49782038
126MP0002272_abnormal_nervous_system0.49539165
127MP0001119_abnormal_female_reproductive0.49439349
128MP0001270_distended_abdomen0.48240297
129MP0009697_abnormal_copulation0.47749376
130MP0003634_abnormal_glial_cell0.47055696
131MP0002116_abnormal_craniofacial_bone0.45498866
132MP0005391_vision/eye_phenotype0.44948154
133MP0002064_seizures0.44596396
134MP0002882_abnormal_neuron_morphology0.44430049
135MP0002063_abnormal_learning/memory/cond0.43831860
136MP0004742_abnormal_vestibular_system0.43632843
137MP0000631_abnormal_neuroendocrine_gland0.43488474
138MP0003115_abnormal_respiratory_system0.43406863
139MP0000750_abnormal_muscle_regeneration0.43314481
140MP0003045_fibrosis0.42834868
141MP0003633_abnormal_nervous_system0.42743363
142MP0002067_abnormal_sensory_capabilities0.42652408
143MP0001963_abnormal_hearing_physiology0.42114188
144MP0003699_abnormal_female_reproductive0.41899247
145MP0005167_abnormal_blood-brain_barrier0.41432691
146MP0000470_abnormal_stomach_morphology0.41244455
147MP0001177_atelectasis0.41090408
148MP0008058_abnormal_DNA_repair0.40912409
149MP0003938_abnormal_ear_development0.40560851
150MP0000751_myopathy0.40152101

Predicted human phenotypes

RankGene SetZ-score
1Rhinitis (HP:0012384)9.69615080
2Abnormal respiratory motile cilium morphology (HP:0005938)9.51256526
3Abnormal respiratory epithelium morphology (HP:0012253)9.51256526
4Chronic bronchitis (HP:0004469)7.76275007
5Nasal polyposis (HP:0100582)5.88304117
6Bronchiectasis (HP:0002110)5.41025955
7Abnormality of the nasal mucosa (HP:0000433)4.84874180
8Infertility (HP:0000789)4.49253978
9Bronchitis (HP:0012387)4.30427860
10Recurrent sinusitis (HP:0011108)3.96322795
11Nephronophthisis (HP:0000090)3.91703370
12Male infertility (HP:0003251)3.55289130
13Tubulointerstitial nephritis (HP:0001970)3.34563502
14Medial flaring of the eyebrow (HP:0010747)3.27796604
15Pancreatic fibrosis (HP:0100732)3.16592393
16Recurrent otitis media (HP:0000403)3.09728327
17True hermaphroditism (HP:0010459)3.08757193
18Abnormality of the renal medulla (HP:0100957)2.98050368
19Gait imbalance (HP:0002141)2.88591466
20Abnormal biliary tract physiology (HP:0012439)2.86572821
21Bile duct proliferation (HP:0001408)2.86572821
22Congenital primary aphakia (HP:0007707)2.85747742
23Molar tooth sign on MRI (HP:0002419)2.80115218
24Abnormality of midbrain morphology (HP:0002418)2.80115218
25Chronic sinusitis (HP:0011109)2.75633528
26Abnormal rod and cone electroretinograms (HP:0008323)2.71035574
27Abnormality of dentin (HP:0010299)2.60093455
28Tubular atrophy (HP:0000092)2.59485238
29Postaxial foot polydactyly (HP:0001830)2.55115393
30Occipital encephalocele (HP:0002085)2.52577313
31Decreased circulating renin level (HP:0003351)2.49473777
32Nephrogenic diabetes insipidus (HP:0009806)2.48274716
33Absent rod-and cone-mediated responses on ERG (HP:0007688)2.41694068
34Supernumerary spleens (HP:0009799)2.40876731
35Pancreatic cysts (HP:0001737)2.40667624
36Congenital stationary night blindness (HP:0007642)2.34311196
37Cystic liver disease (HP:0006706)2.28887389
38Attenuation of retinal blood vessels (HP:0007843)2.25220050
39Congenital hepatic fibrosis (HP:0002612)2.20559021
40Poor coordination (HP:0002370)2.18588734
41Tubulointerstitial abnormality (HP:0001969)2.17853946
42Bony spicule pigmentary retinopathy (HP:0007737)2.14494477
43Stage 5 chronic kidney disease (HP:0003774)2.13636909
44Hyperactive renin-angiotensin system (HP:0000841)2.12327602
45Aplasia/Hypoplasia of the spleen (HP:0010451)2.11841736
46Type II lissencephaly (HP:0007260)2.11273301
47Genital tract atresia (HP:0001827)2.10379708
48Aplasia/Hypoplasia of the tongue (HP:0010295)2.10165072
49Vaginal atresia (HP:0000148)2.08441139
50Chronic hepatic failure (HP:0100626)2.07333850
51Abnormality of macular pigmentation (HP:0008002)2.06803650
52Abnormality of permanent molar morphology (HP:0011071)2.04262903
53Abnormality of the dental root (HP:0006486)2.04262903
54Taurodontia (HP:0000679)2.04262903
55Fibular hypoplasia (HP:0003038)2.03151112
56Chronic otitis media (HP:0000389)2.02913610
57Respiratory insufficiency due to defective ciliary clearance (HP:0200073)14.2045160
58Abnormal respiratory motile cilium physiology (HP:0012261)11.7116286
59Absent/shortened dynein arms (HP:0200106)10.8105663
60Dynein arm defect of respiratory motile cilia (HP:0012255)10.8105663
61Abnormal ciliary motility (HP:0012262)10.5369069
62Recurrent bronchitis (HP:0002837)1.99863096
63Broad distal phalanx of finger (HP:0009836)1.98227443
64Abolished electroretinogram (ERG) (HP:0000550)1.92333917
65Abnormality of molar (HP:0011077)1.91132308
66Abnormality of molar morphology (HP:0011070)1.91132308
67Hyperventilation (HP:0002883)1.89874375
68Median cleft lip (HP:0000161)1.86773378
69Abnormality of the dental pulp (HP:0006479)1.85929767
70Postaxial hand polydactyly (HP:0001162)1.84587148
71Aplasia/Hypoplasia of the lens (HP:0008063)1.84302658
72Anencephaly (HP:0002323)1.83952234
73Abnormality of the renal cortex (HP:0011035)1.83785076
74Absent speech (HP:0001344)1.79138344
75Abnormality of renin-angiotensin system (HP:0000847)1.77631076
76Male pseudohermaphroditism (HP:0000037)1.75880424
77Polydipsia (HP:0001959)1.73340815
78Abnormal drinking behavior (HP:0030082)1.73340815
79Gaze-evoked nystagmus (HP:0000640)1.71822937
80Progressive cerebellar ataxia (HP:0002073)1.68699275
81Hyperaldosteronism (HP:0000859)1.68048110
82Oculomotor apraxia (HP:0000657)1.67200604
83Renal salt wasting (HP:0000127)1.62839592
84Hypokalemic alkalosis (HP:0001949)1.61447793
85Facial cleft (HP:0002006)1.59793034
86Large for gestational age (HP:0001520)1.57732927
87Abnormality of chloride homeostasis (HP:0011422)1.55993210
88Sclerocornea (HP:0000647)1.55089169
89Renal cortical cysts (HP:0000803)1.54889581
90Narrow forehead (HP:0000341)1.53280626
91Cerebellar dysplasia (HP:0007033)1.51382821
92Broad-based gait (HP:0002136)1.50661734
93Preaxial hand polydactyly (HP:0001177)1.49934526
94Constricted visual fields (HP:0001133)1.49518877
95Multicystic kidney dysplasia (HP:0000003)1.48860302
96Back pain (HP:0003418)1.47890668
97Hyperkalemia (HP:0002153)1.47649947
98Severe visual impairment (HP:0001141)1.47294601
99Prominent nasal bridge (HP:0000426)1.46625000
100Aganglionic megacolon (HP:0002251)1.45300892
101Congenital sensorineural hearing impairment (HP:0008527)1.42109505
102Increased corneal curvature (HP:0100692)1.41341946
103Keratoconus (HP:0000563)1.41341946
104Disproportionate short-trunk short stature (HP:0003521)1.40256814
105Aplasia/Hypoplasia of the fibula (HP:0006492)1.28919114
106Broad foot (HP:0001769)1.28684077
107Tubulointerstitial fibrosis (HP:0005576)1.28580414
108Nephropathy (HP:0000112)1.26359477
109Abnormal spermatogenesis (HP:0008669)1.24882991
110Renal dysplasia (HP:0000110)1.21109054
111Abnormality of the fetal cardiovascular system (HP:0010948)1.20619558
112Abnormal umbilical cord blood vessels (HP:0011403)1.20619558
113Single umbilical artery (HP:0001195)1.20619558
114Short ribs (HP:0000773)1.20122806
115Abdominal situs inversus (HP:0003363)1.20096020
116Abnormality of abdominal situs (HP:0011620)1.20096020
117Furrowed tongue (HP:0000221)1.16962047
118Abnormality of the lower motor neuron (HP:0002366)1.16765133
119Abnormality of renal excretion (HP:0011036)1.16438729
120Bell-shaped thorax (HP:0001591)1.15902586
121Specific learning disability (HP:0001328)1.15130773
122Short thorax (HP:0010306)1.14154986
123Hypodontia (HP:0000668)1.13607129
124Polycystic ovaries (HP:0000147)1.13593102
125Degeneration of the lateral corticospinal tracts (HP:0002314)1.13516374
126Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.13516374
127Decreased central vision (HP:0007663)1.10289929
128Short nail (HP:0001799)1.10179316
129Azoospermia (HP:0000027)1.09925887
130Gonadotropin excess (HP:0000837)1.09475355
131Asplenia (HP:0001746)1.09415089
132Dental crowding (HP:0000678)1.09411095
133Retinitis pigmentosa (HP:0000510)1.08882182
134Amyotrophic lateral sclerosis (HP:0007354)1.07459985
135Abnormal urine output (HP:0012590)1.06821336
136Polyuria (HP:0000103)1.06019078

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK36.87806652
2PDK46.87806652
3MAPK156.07744261
4PNCK5.72985554
5FRK5.56283776
6PDK24.43093786
7TESK13.43108818
8MAP4K22.97254582
9WNK32.97239319
10PRKD32.80877732
11ADRBK22.75433718
12PTK2B2.33779178
13ICK2.12434608
14STK392.09617483
15WNK42.03096470
16INSRR2.02795842
17MAPK131.92856648
18TLK11.86483682
19GRK11.85164194
20ACVR1B1.72903596
21NME11.71167772
22OXSR11.66744618
23NUAK11.61086162
24ZAK1.49865482
25WEE11.47274188
26BCR1.47152896
27STK38L1.46550326
28MAPKAPK31.37548468
29BRSK21.28773526
30NTRK21.20897833
31PAK21.14657427
32CASK1.06601610
33VRK11.03928928
34MUSK1.03852644
35CDK31.02343602
36TAOK31.02233005
37PAK31.01809868
38TXK1.01665069
39TNIK1.00442545
40MAP3K91.00016729
41ADRBK10.99160397
42MKNK20.98869536
43TRIM280.97962754
44IRAK10.97272751
45ERBB30.94822359
46DYRK30.91729197
47PLK20.90124167
48DAPK20.87453324
49STK380.86554584
50EEF2K0.81834657
51PLK40.77947485
52PRKCG0.75764773
53DYRK20.74847438
54NEK20.73997801
55MAP3K120.72433965
56CAMKK20.72143207
57LMTK20.71594850
58MAP3K40.69808948
59MAP2K60.66717874
60FGFR20.66523308
61MST40.66278593
62EPHA30.65517658
63RPS6KA20.65299809
64FER0.64802926
65STK240.64728093
66SIK10.63424258
67STK30.62493332
68PHKG20.62049064
69PHKG10.62049064
70PINK10.61537772
71MAPKAPK50.59574133
72TTK0.59033590
73WNK10.58683748
74TGFBR10.58266685
75MAP2K70.57754349
76CSNK1G20.57718816
77PDK10.57457976
78ARAF0.57089938
79STK160.55408455
80BMPR20.55280983
81ERBB20.54243236
82TYRO30.53981145
83MAP3K70.53885738
84BMPR1B0.52430866
85CAMK1G0.51923172
86TIE10.48953235
87BCKDK0.48218074
88GSK3A0.45855610
89CAMK10.45508100
90PRKCI0.44248311
91CHEK20.43872953
92RIPK40.42449081
93AKT30.41363945
94DYRK1B0.41076576
95PRKG20.40777304
96PRKCA0.40283116
97EPHA20.40154719
98CAMK2A0.40144562
99PIK3CA0.38905227
100MAP2K20.37599153
101TEC0.37376574
102CSNK1G10.37329943
103PRKG10.36894549
104PRKCZ0.36640354
105STK100.36616872
106CSNK1G30.35436172
107FES0.34860812
108LATS10.34402569
109CSNK1A10.34349985
110SGK20.34060558
111NEK60.33567719
112CDK120.33049581
113PASK0.33011645
114CDC42BPA0.32814968
115CSNK1A1L0.32248918
116IKBKB0.32159396
117CDC70.31427774
118MARK10.29629220
119RPS6KA50.29259376
120MAP3K20.29059863
121NLK0.27139610
122STK110.24735252
123DMPK0.24498155
124PRKCQ0.23793274
125PRKAA20.23381958
126BRAF0.23257328
127TRPM70.21665319
128CSNK1E0.21464897
129MINK10.21317906
130OBSCN0.18795896
131PRKAA10.18460970
132NTRK30.17030686
133MAPK100.16831359
134LATS20.16493222
135ROCK20.16452893
136ROCK10.16302388
137PRKCE0.16075856
138PAK60.15896787
139MAP3K60.15659952
140ATM0.15418618
141PKN10.15396956
142CHEK10.15205442
143MARK20.15193147
144PDPK10.14874100
145AURKA0.14730361
146PRKACA0.14720791
147SIK20.14604897
148YES10.14273035
149MOS0.14209208
150CAMKK10.13857517
151CAMK2G0.12567440
152PRKACG0.11861352
153NTRK10.11760944
154CSNK1D0.11605319
155PRKDC0.11445115
156EPHA40.11101449
157DYRK1A0.10919050
158PAK10.10525997

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.80917242
2Huntingtons disease_Homo sapiens_hsa050162.98712676
3Pyruvate metabolism_Homo sapiens_hsa006202.82533504
4Butanoate metabolism_Homo sapiens_hsa006502.62381152
5Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.50919889
6Fatty acid biosynthesis_Homo sapiens_hsa000612.36626952
7Propanoate metabolism_Homo sapiens_hsa006402.35789586
8Dorso-ventral axis formation_Homo sapiens_hsa043202.26905123
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.16978173
10Amphetamine addiction_Homo sapiens_hsa050312.15234402
11Histidine metabolism_Homo sapiens_hsa003402.07789260
12Basal transcription factors_Homo sapiens_hsa030222.00708550
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.98948022
14PPAR signaling pathway_Homo sapiens_hsa033201.98007127
15Glucagon signaling pathway_Homo sapiens_hsa049221.97977998
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.94213818
17beta-Alanine metabolism_Homo sapiens_hsa004101.91506447
18Nitrogen metabolism_Homo sapiens_hsa009101.88968618
19Caffeine metabolism_Homo sapiens_hsa002321.83763102
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.82126763
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.73880876
22ABC transporters_Homo sapiens_hsa020101.71962114
23Linoleic acid metabolism_Homo sapiens_hsa005911.68249534
24Tryptophan metabolism_Homo sapiens_hsa003801.68060943
25Renin secretion_Homo sapiens_hsa049241.67556053
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.65112543
27Glycerolipid metabolism_Homo sapiens_hsa005611.64595691
28Ovarian steroidogenesis_Homo sapiens_hsa049131.63041654
29Fanconi anemia pathway_Homo sapiens_hsa034601.60336438
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.55138020
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.54814685
32Estrogen signaling pathway_Homo sapiens_hsa049151.53579755
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.53337004
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.53290795
35Oocyte meiosis_Homo sapiens_hsa041141.52238963
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.51852949
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.47759047
38Collecting duct acid secretion_Homo sapiens_hsa049661.40425400
39Circadian entrainment_Homo sapiens_hsa047131.40172982
40Oxidative phosphorylation_Homo sapiens_hsa001901.40044527
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38526841
42Ether lipid metabolism_Homo sapiens_hsa005651.36551798
43Peroxisome_Homo sapiens_hsa041461.35415627
44Gastric acid secretion_Homo sapiens_hsa049711.32700151
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.32217697
46Insulin secretion_Homo sapiens_hsa049111.31854062
47Cardiac muscle contraction_Homo sapiens_hsa042601.29366238
48Protein export_Homo sapiens_hsa030601.25901933
49Glutathione metabolism_Homo sapiens_hsa004801.25330676
50Olfactory transduction_Homo sapiens_hsa047401.23186568
51Calcium signaling pathway_Homo sapiens_hsa040201.19707213
52Tyrosine metabolism_Homo sapiens_hsa003501.19140755
53Mineral absorption_Homo sapiens_hsa049781.17981207
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16915474
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.15337116
56Glutamatergic synapse_Homo sapiens_hsa047241.14170765
57Cocaine addiction_Homo sapiens_hsa050301.13927636
58Selenocompound metabolism_Homo sapiens_hsa004501.13719632
59Long-term potentiation_Homo sapiens_hsa047201.11261766
60Hedgehog signaling pathway_Homo sapiens_hsa043401.07172652
61Circadian rhythm_Homo sapiens_hsa047101.06982121
62Purine metabolism_Homo sapiens_hsa002301.06939654
63Carbohydrate digestion and absorption_Homo sapiens_hsa049731.06474497
64Phenylalanine metabolism_Homo sapiens_hsa003601.05516946
65cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04757009
66Regulation of autophagy_Homo sapiens_hsa041401.03082593
67Synaptic vesicle cycle_Homo sapiens_hsa047211.02404899
68Serotonergic synapse_Homo sapiens_hsa047261.01242157
69Taste transduction_Homo sapiens_hsa047420.99943116
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.99051243
71Nicotine addiction_Homo sapiens_hsa050330.98421467
72Pentose phosphate pathway_Homo sapiens_hsa000300.96899633
73cAMP signaling pathway_Homo sapiens_hsa040240.96872493
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.95775694
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94355831
76Phototransduction_Homo sapiens_hsa047440.94001581
77Chemical carcinogenesis_Homo sapiens_hsa052040.92981409
78Salivary secretion_Homo sapiens_hsa049700.89777205
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.88627891
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.88346976
81Thyroid hormone synthesis_Homo sapiens_hsa049180.87978982
82Antigen processing and presentation_Homo sapiens_hsa046120.87136698
83Wnt signaling pathway_Homo sapiens_hsa043100.86883822
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.86406126
85Parkinsons disease_Homo sapiens_hsa050120.82486637
86Homologous recombination_Homo sapiens_hsa034400.81988289
87RNA polymerase_Homo sapiens_hsa030200.77470356
88Bile secretion_Homo sapiens_hsa049760.75767237
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74695539
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.74368360
91Dopaminergic synapse_Homo sapiens_hsa047280.74187910
92Carbon metabolism_Homo sapiens_hsa012000.69198705
93Morphine addiction_Homo sapiens_hsa050320.69103078
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65798968
95Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.64136047
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62782721
97GnRH signaling pathway_Homo sapiens_hsa049120.62485110
98Oxytocin signaling pathway_Homo sapiens_hsa049210.61664640
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61590137
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59024914
101Melanogenesis_Homo sapiens_hsa049160.58742198
102Cysteine and methionine metabolism_Homo sapiens_hsa002700.58238686
103Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.57911582
104Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56139905
105GABAergic synapse_Homo sapiens_hsa047270.54514275
106Basal cell carcinoma_Homo sapiens_hsa052170.53623945
107Arachidonic acid metabolism_Homo sapiens_hsa005900.52091765
108Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51307400
109RNA degradation_Homo sapiens_hsa030180.50993752
110Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49461381
111Intestinal immune network for IgA production_Homo sapiens_hsa046720.48361890
112Steroid biosynthesis_Homo sapiens_hsa001000.47902376
113Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47557034
114Pancreatic secretion_Homo sapiens_hsa049720.44932272
115Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44609532
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44136351
117Fatty acid degradation_Homo sapiens_hsa000710.41107245
118Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40775962
119Type I diabetes mellitus_Homo sapiens_hsa049400.40153409
120Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39217736
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38709445
122Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38127720
123Tight junction_Homo sapiens_hsa045300.37772921
124One carbon pool by folate_Homo sapiens_hsa006700.37087240
125Retinol metabolism_Homo sapiens_hsa008300.36197996
126Fatty acid metabolism_Homo sapiens_hsa012120.34263915
127Vitamin digestion and absorption_Homo sapiens_hsa049770.34251107
128Sphingolipid metabolism_Homo sapiens_hsa006000.34143452
129Cholinergic synapse_Homo sapiens_hsa047250.34118905
130Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33676585
131Starch and sucrose metabolism_Homo sapiens_hsa005000.32946098
132Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32007818
133Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31362379
134Metabolic pathways_Homo sapiens_hsa011000.30792009
135Rheumatoid arthritis_Homo sapiens_hsa053230.29781840
136Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28555558
137Alzheimers disease_Homo sapiens_hsa050100.28406727
138Fat digestion and absorption_Homo sapiens_hsa049750.26365354
139Fructose and mannose metabolism_Homo sapiens_hsa000510.26329193
140Nucleotide excision repair_Homo sapiens_hsa034200.26283068
141Phagosome_Homo sapiens_hsa041450.25775303
142Inositol phosphate metabolism_Homo sapiens_hsa005620.24142374

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