CFAP43

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cilia- and flagella-associated protein family. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)9.54975216
2axonemal dynein complex assembly (GO:0070286)8.45966693
3multicellular organism reproduction (GO:0032504)7.69770829
4sperm-egg recognition (GO:0035036)7.49327064
5cell wall macromolecule metabolic process (GO:0044036)7.44260833
6cell wall macromolecule catabolic process (GO:0016998)7.44260833
7plasma membrane fusion (GO:0045026)7.25227529
8sperm motility (GO:0030317)7.23438684
9acrosome assembly (GO:0001675)7.15269126
10motile cilium assembly (GO:0044458)7.09557219
11intraciliary transport (GO:0042073)7.05993605
12cell-cell recognition (GO:0009988)6.87939411
13epithelial cilium movement (GO:0003351)6.87037829
14binding of sperm to zona pellucida (GO:0007339)6.66511356
15microtubule bundle formation (GO:0001578)6.63272259
16cilium movement (GO:0003341)6.62359516
17primary alcohol catabolic process (GO:0034310)6.50944883
18cilium organization (GO:0044782)6.49318134
19reproduction (GO:0000003)6.35358170
20cilium assembly (GO:0042384)6.28166133
21epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.10087511
22vitamin transmembrane transport (GO:0035461)5.90970794
23acrosome reaction (GO:0007340)5.83674935
24piRNA metabolic process (GO:0034587)5.74511455
25spermatid development (GO:0007286)5.50613162
26ethanol metabolic process (GO:0006067)5.45008824
27diterpenoid biosynthetic process (GO:0016102)5.44909024
28microtubule-based movement (GO:0007018)5.24083397
29cellular component assembly involved in morphogenesis (GO:0010927)5.00861828
30single fertilization (GO:0007338)5.00804766
31protein localization to cilium (GO:0061512)4.99841643
32male meiosis (GO:0007140)4.98685956
33response to xenobiotic stimulus (GO:0009410)4.87400331
34synaptonemal complex organization (GO:0070193)4.78450616
35cilium morphogenesis (GO:0060271)4.67093324
36synaptonemal complex assembly (GO:0007130)4.57139238
37regulation of cilium movement (GO:0003352)4.50932070
38cell projection assembly (GO:0030031)4.49985207
39pyrimidine-containing compound transmembrane transport (GO:0072531)4.49886154
40regulation of interleukin-5 production (GO:0032674)4.38075950
41one-carbon compound transport (GO:0019755)4.36450435
42lateral ventricle development (GO:0021670)4.28814640
43lung epithelium development (GO:0060428)4.26064456
44ventricular system development (GO:0021591)4.16810403
45glomerular epithelial cell development (GO:0072310)4.15623325
46fertilization (GO:0009566)4.08018052
47negative regulation of inclusion body assembly (GO:0090084)4.05244975
48ethanol oxidation (GO:0006069)4.05163184
49establishment of apical/basal cell polarity (GO:0035089)4.00611269
50negative regulation of immunoglobulin mediated immune response (GO:0002890)3.98258232
51negative regulation of B cell mediated immunity (GO:0002713)3.98258232
52negative regulation of humoral immune response (GO:0002921)3.95301394
53negative regulation of T cell differentiation in thymus (GO:0033085)3.94451669
54leukocyte aggregation (GO:0070486)3.92776994
55regulation of interleukin-13 production (GO:0032656)3.84801716
56terpenoid biosynthetic process (GO:0016114)3.79209316
57sperm capacitation (GO:0048240)3.75343867
58retinoic acid metabolic process (GO:0042573)3.73548213
59cytoplasmic microtubule organization (GO:0031122)3.69575519
60microtubule polymerization or depolymerization (GO:0031109)3.68117214
61negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.62893175
62establishment or maintenance of monopolar cell polarity (GO:0061339)3.61901584
63establishment of monopolar cell polarity (GO:0061162)3.61901584
64spermatogenesis (GO:0007283)3.60733485
65male gamete generation (GO:0048232)3.59312631
66retinal rod cell development (GO:0046548)3.56411759
67regulation of germinal center formation (GO:0002634)3.54753709
68establishment of planar polarity (GO:0001736)3.48734571
69establishment of tissue polarity (GO:0007164)3.48734571
70determination of left/right symmetry (GO:0007368)3.46491314
71morphogenesis of an endothelium (GO:0003159)3.45113975
72endothelial tube morphogenesis (GO:0061154)3.45113975
73male meiosis I (GO:0007141)3.41915643
74determination of bilateral symmetry (GO:0009855)3.35377023
75gamete generation (GO:0007276)3.28752512
76specification of symmetry (GO:0009799)3.28382243
77positive regulation of smoothened signaling pathway (GO:0045880)3.25892721
78cellular process involved in reproduction in multicellular organism (GO:0022412)3.24760081
79meiotic cell cycle (GO:0051321)3.24067687
80seminiferous tubule development (GO:0072520)3.23034972
81antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.20605974
82antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.20605974
83chromosome organization involved in meiosis (GO:0070192)3.18263119
84meiotic nuclear division (GO:0007126)3.16458334
85lateral sprouting from an epithelium (GO:0060601)3.16213122
86nuclear pore complex assembly (GO:0051292)3.12705911
87left/right pattern formation (GO:0060972)3.12697638
88regulation of podosome assembly (GO:0071801)3.12658847
89germ cell development (GO:0007281)3.12619415
90exogenous drug catabolic process (GO:0042738)3.11515891
91monoubiquitinated protein deubiquitination (GO:0035520)3.11076893
92DNA methylation involved in gamete generation (GO:0043046)3.10960412
93smoothened signaling pathway (GO:0007224)3.06893713
94microtubule-based process (GO:0007017)3.06835221
95antigen processing and presentation of endogenous antigen (GO:0019883)2.99020551
96O-glycan processing (GO:0016266)2.98458339
97apical protein localization (GO:0045176)2.91272150
98primary alcohol metabolic process (GO:0034308)2.89551292
99regulation of inclusion body assembly (GO:0090083)2.88568677
100microtubule depolymerization (GO:0007019)2.86907182
101gene silencing by RNA (GO:0031047)2.85269000
102glutathione derivative metabolic process (GO:1901685)2.84326350
103glutathione derivative biosynthetic process (GO:1901687)2.84326350
104regulation of B cell receptor signaling pathway (GO:0050855)2.83771722
105meiosis I (GO:0007127)2.82861646
106organelle assembly (GO:0070925)2.82187790
107cellular extravasation (GO:0045123)2.82137763
108retinol metabolic process (GO:0042572)2.80899472
109sequestering of actin monomers (GO:0042989)2.80559419
110mitotic sister chromatid cohesion (GO:0007064)2.80007460
111positive regulation of gamma-delta T cell activation (GO:0046645)2.77505074
112positive thymic T cell selection (GO:0045059)2.77159997
113organic cation transport (GO:0015695)2.76832093
114retinal cone cell development (GO:0046549)2.76738541
115chromosome condensation (GO:0030261)2.76597315
116cellular hyperosmotic response (GO:0071474)2.75181754
117microtubule severing (GO:0051013)2.71425635
118carnitine metabolic process (GO:0009437)2.69982133
119cell recognition (GO:0008037)2.69058623
120heart looping (GO:0001947)2.68415068
121genitalia morphogenesis (GO:0035112)2.67879506
122positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.67766624
123hydrogen peroxide biosynthetic process (GO:0050665)2.66537810
124regulation of microtubule depolymerization (GO:0031114)2.64035516
125photoreceptor cell maintenance (GO:0045494)2.61933539
126multicellular organismal reproductive process (GO:0048609)2.58079604
127intra-S DNA damage checkpoint (GO:0031573)2.57988635
128axoneme assembly (GO:0035082)2.57612738
129spermatid nucleus differentiation (GO:0007289)2.56312201
130DNA packaging (GO:0006323)2.55192472
131negative regulation of necroptotic process (GO:0060546)2.52042759
132left/right axis specification (GO:0070986)2.50356362
133regulation of necroptotic process (GO:0060544)2.50069082
134regulation of tolerance induction (GO:0002643)2.48283160
135phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.47592558
136asymmetric protein localization (GO:0008105)2.46998880
137dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.46525810
138drug catabolic process (GO:0042737)2.46144077
139aldehyde catabolic process (GO:0046185)2.45792855
140nonmotile primary cilium assembly (GO:0035058)2.45348817
141Arp2/3 complex-mediated actin nucleation (GO:0034314)2.44310593
142regulation of smoothened signaling pathway (GO:0008589)2.43916153
143embryonic heart tube morphogenesis (GO:0003143)2.43779429
144embryonic camera-type eye development (GO:0031076)2.42558313
145multicellular organismal water homeostasis (GO:0050891)2.42508079
146excretion (GO:0007588)2.41634359
147nuclear pore organization (GO:0006999)2.41553011
148natural killer cell mediated immunity (GO:0002228)2.40937085
149natural killer cell mediated cytotoxicity (GO:0042267)2.40937085
150regulation of gamma-delta T cell differentiation (GO:0045586)2.40516669
151positive regulation of histone deacetylation (GO:0031065)2.40503606
152translesion synthesis (GO:0019985)2.38586947
153pore complex assembly (GO:0046931)2.38139109
154positive regulation of lamellipodium assembly (GO:0010592)2.35610139
155reactive oxygen species biosynthetic process (GO:1903409)2.34819010
156phosphatidylcholine biosynthetic process (GO:0006656)2.34658702
157centriole assembly (GO:0098534)2.34024220
158regulation of histone H3-K9 methylation (GO:0051570)2.32903786
159polyol transport (GO:0015791)2.32291882
160regulation of autophagic vacuole assembly (GO:2000785)2.29116954
161GTP biosynthetic process (GO:0006183)2.28204816
162nucleoside diphosphate phosphorylation (GO:0006165)2.27885330
163sodium ion homeostasis (GO:0055078)2.27549017
164interferon-gamma secretion (GO:0072643)2.27071811
165regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.26702001
166UTP biosynthetic process (GO:0006228)2.25540010
167positive regulation of tolerance induction (GO:0002645)2.25310062
168tolerance induction (GO:0002507)2.23431266
169detection of bacterium (GO:0016045)2.22986112
170protein localization to chromosome, centromeric region (GO:0071459)2.21791300
171negative regulation of phagocytosis (GO:0050765)2.21467627
172regulation of centriole replication (GO:0046599)2.21465699
173centriole replication (GO:0007099)2.21293625
174heterochromatin organization (GO:0070828)2.20787702
175regulation of microtubule-based movement (GO:0060632)2.19962886
176multicellular organismal development (GO:0007275)2.19391195
177thymic T cell selection (GO:0045061)2.19067637
178cilium or flagellum-dependent cell motility (GO:0001539)11.3090080

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.54857565
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.93115651
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.83333725
4DROSHA_22980978_ChIP-Seq_HELA_Human3.39836514
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.37728589
6FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.35872336
7E2F7_22180533_ChIP-Seq_HELA_Human3.27276195
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.93718090
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.90478647
10MYB_21317192_ChIP-Seq_ERMYB_Mouse2.67702494
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.67677944
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.65499218
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.50034257
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.35925481
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.31254704
16MYB_26560356_Chip-Seq_TH2_Human2.27951797
17PIAS1_25552417_ChIP-Seq_VCAP_Human2.24691046
18IRF8_22096565_ChIP-ChIP_GC-B_Human2.21748555
19ESR1_20079471_ChIP-ChIP_T-47D_Human2.21608104
20FOXM1_23109430_ChIP-Seq_U2OS_Human2.20924121
21BRD4_27068464_Chip-Seq_AML-cells_Mouse2.17595972
22SCL_19346495_ChIP-Seq_HPC-7_Human2.13123432
23AHR_22903824_ChIP-Seq_MCF-7_Human2.12991620
24STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.10143845
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.08759513
26IRF8_27001747_Chip-Seq_BMDM_Mouse2.07313940
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.03752049
28MYC_22102868_ChIP-Seq_BL_Human2.01751818
29MYB_26560356_Chip-Seq_TH1_Human2.00962594
30MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.00335160
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.99388057
32MAF_26560356_Chip-Seq_TH1_Human1.98450080
33TRIM28_21343339_ChIP-Seq_HEK293_Human1.95379036
34FOXM1_26456572_ChIP-Seq_MCF-7_Human1.95341094
35VDR_22108803_ChIP-Seq_LS180_Human1.94785921
36VDR_21846776_ChIP-Seq_THP-1_Human1.94465009
37TCF7_22412390_ChIP-Seq_EML_Mouse1.93234199
38STAT4_19710469_ChIP-ChIP_TH1__Mouse1.88189734
39ARNT_22903824_ChIP-Seq_MCF-7_Human1.88104338
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.87253718
41UTX_26944678_Chip-Seq_JUKART_Human1.86280139
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.83068633
43NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.82709462
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.80696219
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79887789
46ZNF217_24962896_ChIP-Seq_MCF-7_Human1.79308853
47NR3C1_21868756_ChIP-Seq_MCF10A_Human1.77048079
48FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.76761966
49TP63_23658742_ChIP-Seq_EP156T_Human1.70169614
50CTNNB1_20460455_ChIP-Seq_HCT116_Human1.61401189
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.60320397
52VDR_24763502_ChIP-Seq_THP-1_Human1.60197878
53TP53_18474530_ChIP-ChIP_U2OS_Human1.58752188
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.56393493
55IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.55976406
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53483241
57RUNX1_27514584_Chip-Seq_MCF-7_Human1.53414692
58CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.52819486
59AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.51955752
60SPI1_23547873_ChIP-Seq_NB4_Human1.51852772
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.51202562
62CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.50846406
63RUNX_20019798_ChIP-Seq_JUKART_Human1.50615491
64SOX2_27498859_Chip-Seq_STOMACH_Mouse1.50528637
65TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.49163882
66SMAD4_21799915_ChIP-Seq_A2780_Human1.48479247
67ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.48370019
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45282453
69ETV1_20927104_ChIP-Seq_GIST48_Human1.44987213
70STAT1_20625510_ChIP-Seq_HELA_Human1.44851107
71GATA3_27048872_Chip-Seq_THYMUS_Human1.44349170
72ESR1_21235772_ChIP-Seq_MCF-7_Human1.42874885
73ESR2_21235772_ChIP-Seq_MCF-7_Human1.42318540
74SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.41888639
75PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.41687652
76TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.41185055
77KLF5_25053715_ChIP-Seq_YYC3_Human1.40948073
78LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.39578242
79FOXA1_25552417_ChIP-Seq_VCAP_Human1.38593624
80SMC4_20622854_ChIP-Seq_HELA_Human1.38151622
81AR_21572438_ChIP-Seq_LNCaP_Human1.37648576
82PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.35286297
83SMRT_27268052_Chip-Seq_Bcells_Human1.34179205
84PHF8_20622853_ChIP-Seq_HELA_Human1.33656797
85SPI1_23127762_ChIP-Seq_K562_Human1.33084948
86SOX9_24532713_ChIP-Seq_HFSC_Mouse1.31951320
87MAF_26560356_Chip-Seq_TH2_Human1.31676888
88RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.30685414
89FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30682597
90PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.29868969
91CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.29835117
92HNFA_21074721_ChIP-Seq_CACO-2_Human1.29179194
93NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.27117055
94CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26820290
95PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25591723
96KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.25133701
97GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.23767631
98E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.23431160
99SMAD3_21741376_ChIP-Seq_EPCs_Human1.23295854
100SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.22162434
101TP53_16413492_ChIP-PET_HCT116_Human1.21817555
102GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21280613
103PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21098093
104FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.20855219
105CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19724567
106STAT3_23295773_ChIP-Seq_U87_Human1.19068155
107TP63_22573176_ChIP-Seq_HFKS_Human1.18734509
108SOX2_20726797_ChIP-Seq_SW620_Human1.18722518
109TDRD3_21172665_ChIP-Seq_MCF-7_Human1.18474405
110SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18458680
111SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18445503
112ELK3_25401928_ChIP-Seq_HUVEC_Human1.18425469
113STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.18062232
114PU_27001747_Chip-Seq_BMDM_Mouse1.16682852
115RBPJ_21746931_ChIP-Seq_IB4_Human1.15188526
116NOTCH1_21737748_ChIP-Seq_TLL_Human1.14487813
117SMAD3_21741376_ChIP-Seq_HESCs_Human1.14363498
118NFYA_21822215_ChIP-Seq_K562_Human1.14288255
119ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.14181259
120TBL1_22424771_ChIP-Seq_293T_Human1.14115134
121KDM2B_26808549_Chip-Seq_DND41_Human1.12739587
122KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.12569375
123RAD21_21589869_ChIP-Seq_MESCs_Mouse1.12539933
124CBX2_22325352_ChIP-Seq_293T-Rex_Human1.12365798
125TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.12226253
126NFYB_21822215_ChIP-Seq_K562_Human1.12105080
127P63_26484246_Chip-Seq_KERATINOCYTES_Human1.11912388
128PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10314131
129CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.10076036
130CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08874273
131ELF1_20517297_ChIP-Seq_JURKAT_Human1.08860102
132AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08849167
133BCAT_22108803_ChIP-Seq_LS180_Human1.08595304
134TCF4_22108803_ChIP-Seq_LS180_Human1.08280163
135CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07906820
136CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07460588
137CDX2_20551321_ChIP-Seq_CACO-2_Human1.07157263
138CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05943465
139NCOR1_26117541_ChIP-Seq_K562_Human1.05884491
140TP63_17297297_ChIP-ChIP_HaCaT_Human1.05788618
141SMAD4_21741376_ChIP-Seq_EPCs_Human1.05217333
142GATA4_25053715_ChIP-Seq_YYC3_Human1.05181842
143HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04068884
144EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03739163
145FOXA2_19822575_ChIP-Seq_HepG2_Human1.03568244
146TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03504164
147SPI1_20517297_ChIP-Seq_HL60_Human1.03333907
148PPAR_26484153_Chip-Seq_NCI-H1993_Human1.02941086
149FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.02867872
150E2F4_17652178_ChIP-ChIP_JURKAT_Human1.02827344
151FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02559910
152GATA6_21074721_ChIP-Seq_CACO-2_Human1.02139965
153FOXO3_23340844_ChIP-Seq_DLD1_Human1.02026247
154FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.01584436
155CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01320790
156Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.00269598
157STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.99796156
158GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.99726742
159CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98624066
160TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98532712
161SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.98361427
162GATA3_26560356_Chip-Seq_TH2_Human0.98313524
163FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.97636453
164TCF4_23295773_ChIP-Seq_U87_Human0.97501620
165CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97299867
166ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97210432
167CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96941607
168MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96180391
169WDR5_24793694_ChIP-Seq_LNCAP_Human0.95544696
170SMAD4_21741376_ChIP-Seq_HESCs_Human0.94929945
171PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94698998
172CEBPB_22108803_ChIP-Seq_LS180_Human0.93759586
173GATA3_24758297_ChIP-Seq_MCF-7_Human0.93347189
174PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91697579
175RARG_19884340_ChIP-ChIP_MEFs_Mouse0.91190505
176RUNX2_22187159_ChIP-Seq_PCA_Human0.91102171
177EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.90803751
178BCOR_27268052_Chip-Seq_Bcells_Human0.90744690
179SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.90507913
180BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90466608
181POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90247252
182TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90247252
183EZH2_27294783_Chip-Seq_ESCs_Mouse0.90244818
184VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.90235395
185KDM2B_26808549_Chip-Seq_SUP-B15_Human0.90184786
186CBP_20019798_ChIP-Seq_JUKART_Human0.90099492
187IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90099492
188CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90040661
189SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.90012914
190SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89336891
191TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.88424024
192BCL6_27268052_Chip-Seq_Bcells_Human0.86035506
193CTCF_26484167_Chip-Seq_Bcells_Mouse0.85995939
194GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84786483
195RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.84756462
196NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.84094075
197ELK4_26923725_Chip-Seq_MESODERM_Mouse0.84056274
198NFIB_24661679_ChIP-Seq_LUNG_Mouse0.80128514

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.90531963
2MP0008875_abnormal_xenobiotic_pharmacok6.37229549
3MP0001984_abnormal_olfaction4.11695044
4MP0004043_abnormal_pH_regulation3.70982984
5MP0004133_heterotaxia3.60792404
6MP0002277_abnormal_respiratory_mucosa3.47102031
7MP0009780_abnormal_chondrocyte_physiolo3.29529504
8MP0009278_abnormal_bone_marrow3.03756089
9MP0000566_synostosis2.99625084
10MP0008789_abnormal_olfactory_epithelium2.98069174
11MP0000383_abnormal_hair_follicle2.79716541
12MP0001929_abnormal_gametogenesis2.46119611
13MP0004808_abnormal_hematopoietic_stem2.38493866
14MP0003698_abnormal_male_reproductive2.37342268
15MP0010678_abnormal_skin_adnexa2.34450290
16MP0005397_hematopoietic_system_phenotyp2.32416926
17MP0001545_abnormal_hematopoietic_system2.32416926
18MP0003436_decreased_susceptibility_to2.29570770
19MP0000685_abnormal_immune_system2.27066140
20MP0005377_hearing/vestibular/ear_phenot2.23543905
21MP0003878_abnormal_ear_physiology2.23543905
22MP0005623_abnormal_meninges_morphology2.13570410
23MP0003303_peritoneal_inflammation2.12392762
24MP0003279_aneurysm2.02949984
25MP0002160_abnormal_reproductive_system2.00524833
26MP0003763_abnormal_thymus_physiology1.98219825
27MP0004019_abnormal_vitamin_homeostasis1.98178830
28MP0005394_taste/olfaction_phenotype1.96389049
29MP0005499_abnormal_olfactory_system1.96389049
30MP0002405_respiratory_system_inflammati1.93449662
31MP0001835_abnormal_antigen_presentation1.92585760
32MP0010352_gastrointestinal_tract_polyps1.90246368
33MP0008877_abnormal_DNA_methylation1.88002304
34MP0009785_altered_susceptibility_to1.85409257
35MP0002168_other_aberrant_phenotype1.84140173
36MP0003300_gastrointestinal_ulcer1.82571920
37MP0001800_abnormal_humoral_immune1.78804243
38MP0001346_abnormal_lacrimal_gland1.77082561
39MP0002396_abnormal_hematopoietic_system1.73972271
40MP0005387_immune_system_phenotype1.73853803
41MP0001790_abnormal_immune_system1.73853803
42MP0003724_increased_susceptibility_to1.73044121
43MP0003656_abnormal_erythrocyte_physiolo1.67415236
44MP0002452_abnormal_antigen_presenting1.66698255
45MP0005000_abnormal_immune_tolerance1.63996387
46MP0003566_abnormal_cell_adhesion1.63568800
47MP0006054_spinal_hemorrhage1.61838373
48MP0002210_abnormal_sex_determination1.60843770
49MP0002420_abnormal_adaptive_immunity1.60408646
50MP0010030_abnormal_orbit_morphology1.60402891
51MP0002653_abnormal_ependyma_morphology1.60245386
52MP0005023_abnormal_wound_healing1.59193241
53MP0005248_abnormal_Harderian_gland1.58724484
54MP0001819_abnormal_immune_cell1.58562161
55MP0002723_abnormal_immune_serum1.55225333
56MP0002398_abnormal_bone_marrow1.54737572
57MP0002419_abnormal_innate_immunity1.53823006
58MP0001765_abnormal_ion_homeostasis1.53726277
59MP0001958_emphysema1.53232479
60MP0005025_abnormal_response_to1.52012492
61MP0005083_abnormal_biliary_tract1.50075613
62MP0001853_heart_inflammation1.47489146
63MP0001873_stomach_inflammation1.46500934
64MP0002909_abnormal_adrenal_gland1.45508558
65MP0000465_gastrointestinal_hemorrhage1.45407281
66MP0004947_skin_inflammation1.42453694
67MP0002249_abnormal_larynx_morphology1.38111491
68MP0002933_joint_inflammation1.37756141
69MP0000678_abnormal_parathyroid_gland1.34333263
70MP0000716_abnormal_immune_system1.33073353
71MP0001145_abnormal_male_reproductive1.31627442
72MP0003705_abnormal_hypodermis_morpholog1.30400665
73MP0000858_altered_metastatic_potential1.27490518
74MP0000689_abnormal_spleen_morphology1.27158480
75MP0002161_abnormal_fertility/fecundity1.27126684
76MP0000703_abnormal_thymus_morphology1.26836370
77MP0001533_abnormal_skeleton_physiology1.25732998
78MP0002148_abnormal_hypersensitivity_rea1.25032607
79MP0005671_abnormal_response_to1.24967804
80MP0008007_abnormal_cellular_replicative1.24664459
81MP0002233_abnormal_nose_morphology1.24578693
82MP0002166_altered_tumor_susceptibility1.23956586
83MP0005395_other_phenotype1.21563701
84MP0002722_abnormal_immune_system1.21127102
85MP0002282_abnormal_trachea_morphology1.20899372
86MP0010094_abnormal_chromosome_stability1.19042005
87MP0002734_abnormal_mechanical_nocicepti1.18991827
88MP0001851_eye_inflammation1.16960434
89MP0005076_abnormal_cell_differentiation1.16698000
90MP0002429_abnormal_blood_cell1.16196591
91MP0008438_abnormal_cutaneous_collagen1.15857909
92MP0002132_abnormal_respiratory_system1.14576700
93MP0005464_abnormal_platelet_physiology1.12395715
94MP0001845_abnormal_inflammatory_respons1.11307396
95MP0000653_abnormal_sex_gland1.08980223
96MP0003136_yellow_coat_color1.08010799
97MP0003091_abnormal_cell_migration1.07156600
98MP0002638_abnormal_pupillary_reflex1.07008406
99MP0000343_altered_response_to1.04524443
100MP0001485_abnormal_pinna_reflex1.04048026
101MP0003448_altered_tumor_morphology1.01450297
102MP0009046_muscle_twitch1.00890283
103MP0005636_abnormal_mineral_homeostasis0.99491911
104MP0010155_abnormal_intestine_physiology0.99352584
105MP0005253_abnormal_eye_physiology0.99284122
106MP0008057_abnormal_DNA_replication0.98316214
107MP0005275_abnormal_skin_tensile0.97203810
108MP0005389_reproductive_system_phenotype0.96851297
109MP0001293_anophthalmia0.96283989
110MP0009333_abnormal_splenocyte_physiolog0.93538935
111MP0003077_abnormal_cell_cycle0.92206135
112MP0010234_abnormal_vibrissa_follicle0.92051657
113MP0010307_abnormal_tumor_latency0.91919034
114MP0002138_abnormal_hepatobiliary_system0.90861785
115MP0002928_abnormal_bile_duct0.90231752
116MP0002019_abnormal_tumor_incidence0.89926442
117MP0002876_abnormal_thyroid_physiology0.88469922
118MP0005165_increased_susceptibility_to0.86977901
119MP0002735_abnormal_chemical_nociception0.86956874
120MP0000026_abnormal_inner_ear0.86744885
121MP0003890_abnormal_embryonic-extraembry0.86607568
122MP0000767_abnormal_smooth_muscle0.86462103
123MP0001348_abnormal_lacrimal_gland0.85981410
124MP0010368_abnormal_lymphatic_system0.85705727
125MP0003937_abnormal_limbs/digits/tail_de0.85265396
126MP0000490_abnormal_crypts_of0.84462730
127MP0002006_tumorigenesis0.82551957
128MP0002060_abnormal_skin_morphology0.80862862
129MP0009379_abnormal_foot_pigmentation0.80757354
130MP0003045_fibrosis0.80744579
131MP0000681_abnormal_thyroid_gland0.79373945
132MP0003111_abnormal_nucleus_morphology0.79154702
133MP0000733_abnormal_muscle_development0.79117780
134MP0003828_pulmonary_edema0.78628766
135MP0005551_abnormal_eye_electrophysiolog0.78438468
136MP0005365_abnormal_bile_salt0.77774621
137MP0005408_hypopigmentation0.77351874
138MP0001299_abnormal_eye_distance/0.76345012
139MP0005503_abnormal_tendon_morphology0.75817390
140MP0001879_abnormal_lymphatic_vessel0.75256329
141MP0001270_distended_abdomen0.74462602
142MP0005220_abnormal_exocrine_pancreas0.74326613
143MP0005390_skeleton_phenotype0.74290028
144MP0005164_abnormal_response_to0.73884678
145MP0001243_abnormal_dermal_layer0.73336763
146MP0001216_abnormal_epidermal_layer0.73175010
147MP0004883_abnormal_blood_vessel0.72482697
148MP0001324_abnormal_eye_pigmentation0.70774540
149MP0003693_abnormal_embryo_hatching0.70372528
150MP0005391_vision/eye_phenotype0.70116602
151MP0005670_abnormal_white_adipose0.69180166
152MP0002925_abnormal_cardiovascular_devel0.68453151
153MP0009643_abnormal_urine_homeostasis0.68322397
154MP0005388_respiratory_system_phenotype0.67772312
155MP0002133_abnormal_respiratory_system0.67772312
156MP0009703_decreased_birth_body0.67537117
157MP0004264_abnormal_extraembryonic_tissu0.67466917
158MP0002116_abnormal_craniofacial_bone0.66985838
159MP0002136_abnormal_kidney_physiology0.66960438
160MP0001849_ear_inflammation0.66697635
161MP0001502_abnormal_circadian_rhythm0.66477891
162MP0005085_abnormal_gallbladder_physiolo0.64376673
163MP0008058_abnormal_DNA_repair0.64041939
164MP0002822_catalepsy0.63104520
165MP0005174_abnormal_tail_pigmentation0.62919127
166MP0003453_abnormal_keratinocyte_physiol0.62484284
167MP0002084_abnormal_developmental_patter0.61708890
168MP0002128_abnormal_blood_circulation0.61585148
169MP0004510_myositis0.61365281
170MP0003861_abnormal_nervous_system0.61142970
171MP0005195_abnormal_posterior_eye0.60743007
172MP0003938_abnormal_ear_development0.58499716
173MP0000955_abnormal_spinal_cord0.58308727
174MP0002098_abnormal_vibrissa_morphology0.58030519
175MP0005310_abnormal_salivary_gland0.55718760
176MP0001963_abnormal_hearing_physiology0.54669406
177MP0002229_neurodegeneration0.54539530
178MP0009765_abnormal_xenobiotic_induced0.53046949
179MP0000049_abnormal_middle_ear0.52946920
180MP0000631_abnormal_neuroendocrine_gland0.50869476
181MP0002139_abnormal_hepatobiliary_system0.49885532
182MP0002896_abnormal_bone_mineralization0.48132912
183MP0002092_abnormal_eye_morphology0.47212291
184MP0001664_abnormal_digestion0.46312376
185MP0003943_abnormal_hepatobiliary_system0.46095639
186MP0005409_darkened_coat_color0.45559347
187MP0001486_abnormal_startle_reflex0.45337654
188MP0001970_abnormal_pain_threshold0.45083478

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)8.66563180
2Absent/shortened dynein arms (HP:0200106)8.66563180
3Abnormal respiratory motile cilium physiology (HP:0012261)7.42345239
4Nasal polyposis (HP:0100582)6.86945525
5Abnormality of the nasal mucosa (HP:0000433)6.67454668
6Abnormal respiratory epithelium morphology (HP:0012253)6.58994424
7Abnormal respiratory motile cilium morphology (HP:0005938)6.58994424
8Rhinitis (HP:0012384)6.54733649
9Chronic bronchitis (HP:0004469)6.13851222
10Abnormal ciliary motility (HP:0012262)6.03732818
11Bronchitis (HP:0012387)4.85270711
12Bronchiectasis (HP:0002110)4.61971925
13Infertility (HP:0000789)4.19150418
14Recurrent bronchitis (HP:0002837)3.99550371
15Recurrent sinusitis (HP:0011108)3.92190044
16Occipital encephalocele (HP:0002085)3.77372622
17Pancreatic fibrosis (HP:0100732)3.58903907
18True hermaphroditism (HP:0010459)3.48121468
19Recurrent otitis media (HP:0000403)3.38529857
20Spontaneous hematomas (HP:0007420)3.02814700
21Chronic sinusitis (HP:0011109)3.01194410
22Cystic liver disease (HP:0006706)2.91959874
23Chronic hepatic failure (HP:0100626)2.91375075
24Pancreatic cysts (HP:0001737)2.90994602
25Atelectasis (HP:0100750)2.88295463
26Male infertility (HP:0003251)2.86322980
27Nephronophthisis (HP:0000090)2.83558444
28Hyperactive renin-angiotensin system (HP:0000841)2.70487508
29Myositis (HP:0100614)2.61914334
30Recurrent abscess formation (HP:0002722)2.42739918
31Chronic otitis media (HP:0000389)2.42730365
32Eczematoid dermatitis (HP:0000976)2.34780561
33Absent frontal sinuses (HP:0002688)2.23332049
34Abnormality of the renal medulla (HP:0100957)2.20613310
35Tubular atrophy (HP:0000092)2.20442174
36Bell-shaped thorax (HP:0001591)2.19799121
37Protrusio acetabuli (HP:0003179)2.18937931
38Hematochezia (HP:0002573)2.17673992
39Congenital hepatic fibrosis (HP:0002612)2.16372068
40High pitched voice (HP:0001620)2.10929969
41Medial flaring of the eyebrow (HP:0010747)2.04916183
42Aplasia/Hypoplasia of the tongue (HP:0010295)2.03551826
43Recurrent bacterial skin infections (HP:0005406)2.03539939
44Anencephaly (HP:0002323)2.00511418
45Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.6074028
4611 pairs of ribs (HP:0000878)1.97950262
47Abnormality of dentin (HP:0010299)1.97204586
48Cellulitis (HP:0100658)1.90470505
49Congenital primary aphakia (HP:0007707)1.87972320
50Conjunctival telangiectasia (HP:0000524)1.86876908
51Gait imbalance (HP:0002141)1.86119695
52Male pseudohermaphroditism (HP:0000037)1.84423350
53Thrombocytosis (HP:0001894)1.77813903
54Gastrointestinal inflammation (HP:0004386)1.76514953
55Inflammation of the large intestine (HP:0002037)1.76079300
56Orchitis (HP:0100796)1.75542119
57Oculomotor apraxia (HP:0000657)1.74211592
58Premature rupture of membranes (HP:0001788)1.70788975
59Asplenia (HP:0001746)1.68871716
60Chronic obstructive pulmonary disease (HP:0006510)1.68799765
61Obstructive lung disease (HP:0006536)1.68799765
62Selective tooth agenesis (HP:0001592)1.67825823
63Sclerocornea (HP:0000647)1.67423828
64Aplasia/Hypoplasia of the spleen (HP:0010451)1.66653589
65Stage 5 chronic kidney disease (HP:0003774)1.66448663
66Postaxial hand polydactyly (HP:0001162)1.66411946
67Recurrent fungal infections (HP:0002841)1.65768551
68Short 4th metacarpal (HP:0010044)1.65467855
69Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.65467855
70Short nail (HP:0001799)1.65116108
71Cerebral aneurysm (HP:0004944)1.64878498
72Elevated erythrocyte sedimentation rate (HP:0003565)1.64340032
73Abnormality of midbrain morphology (HP:0002418)1.64187834
74Molar tooth sign on MRI (HP:0002419)1.64187834
75Hypoplasia of the capital femoral epiphysis (HP:0003090)1.64013606
76Furrowed tongue (HP:0000221)1.63891555
77Nephrogenic diabetes insipidus (HP:0009806)1.63421611
78Decreased circulating renin level (HP:0003351)1.63140644
79Nephropathy (HP:0000112)1.62920932
80Aortic aneurysm (HP:0004942)1.62084312
81Aortic dissection (HP:0002647)1.61344332
82Absent rod-and cone-mediated responses on ERG (HP:0007688)1.61071792
83Renal salt wasting (HP:0000127)1.61040995
84Fibular hypoplasia (HP:0003038)1.60481289
85Abnormality of the vasculature of the conjunctiva (HP:0008054)1.59403837
86Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.58338925
87Increased density of long bones (HP:0006392)1.57584941
88Recurrent gram-negative bacterial infections (HP:0005420)1.57149517
89Tubulointerstitial nephritis (HP:0001970)1.56165324
90Osteolytic defects of the phalanges of the hand (HP:0009771)1.55440503
91Osteolytic defects of the hand bones (HP:0009699)1.55440503
92Polydipsia (HP:0001959)1.54686677
93Abnormal drinking behavior (HP:0030082)1.54686677
94Polycythemia (HP:0001901)1.52154005
95Meningitis (HP:0001287)1.51646288
96Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.51577489
97Peritonitis (HP:0002586)1.50839351
98Bicuspid aortic valve (HP:0001647)1.50556422
99Abnormal spermatogenesis (HP:0008669)1.49661030
100Hyperkalemia (HP:0002153)1.48375339
101Abnormal delayed hypersensitivity skin test (HP:0002963)1.46118885
102Mediastinal lymphadenopathy (HP:0100721)1.45146240
103Median cleft lip (HP:0000161)1.44251845
104Recurrent viral infections (HP:0004429)1.43105994
105Deformed sella turcica (HP:0002681)1.42096482
106Preaxial hand polydactyly (HP:0001177)1.41751041
107Dislocated radial head (HP:0003083)1.38908178
108Interstitial pulmonary disease (HP:0006530)1.38322133
109Cone-rod dystrophy (HP:0000548)1.37093401
110Arterial thrombosis (HP:0004420)1.36760075
111Hyperaldosteronism (HP:0000859)1.35741333
112Tubulointerstitial abnormality (HP:0001969)1.34934642
113Retrobulbar optic neuritis (HP:0100654)1.34649573
114Optic neuritis (HP:0100653)1.34649573
115Weak cry (HP:0001612)1.33949104
116Vaginal atresia (HP:0000148)1.33945394
117Genital tract atresia (HP:0001827)1.33768826
118Cervical subluxation (HP:0003308)1.33614258
119Abnormality of T cells (HP:0002843)1.33608585
120Poor coordination (HP:0002370)1.32377372
121Autoimmune thrombocytopenia (HP:0001973)1.32313920
122Abnormality of T cell number (HP:0011839)1.32045644
123Short ribs (HP:0000773)1.32007169
124Easy fatigability (HP:0003388)1.31318343
125Acute myeloid leukemia (HP:0004808)1.29937942
126Spondylolisthesis (HP:0003302)1.29789770
127Pustule (HP:0200039)1.29200464
128Hyperacusis (HP:0010780)1.28910928
129Postaxial foot polydactyly (HP:0001830)1.28757926
130Abnormality of the peritoneum (HP:0002585)1.28564379
131Abnormality of chloride homeostasis (HP:0011422)1.27778402
132Abnormality of the radial head (HP:0003995)1.27568224
133Absent epiphyses (HP:0010577)1.27488294
134Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.27488294
135Short femoral neck (HP:0100864)1.27390156
136Heterotopia (HP:0002282)1.27363655
137Short thorax (HP:0010306)1.25805552
138Abnormality of permanent molar morphology (HP:0011071)1.24769966
139Abnormality of the dental root (HP:0006486)1.24769966
140Taurodontia (HP:0000679)1.24769966
141Supernumerary spleens (HP:0009799)1.22114330
142Bile duct proliferation (HP:0001408)1.21517707
143Abnormal biliary tract physiology (HP:0012439)1.21517707
144Abnormality of renin-angiotensin system (HP:0000847)1.19454692
145Decreased central vision (HP:0007663)1.17160858
146Abnormality of the frontal sinuses (HP:0002687)1.15638778
147Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.15187359
148Abnormality of molar (HP:0011077)1.14731276
149Abnormality of molar morphology (HP:0011070)1.14731276
150Hypokalemic alkalosis (HP:0001949)1.14405238
151Glucose intolerance (HP:0000833)1.14394343
152Bifid scrotum (HP:0000048)1.12133064
153Abnormality of the dental pulp (HP:0006479)1.12064834
154Abnormal rod and cone electroretinograms (HP:0008323)1.08277177
155Tubulointerstitial fibrosis (HP:0005576)1.07828471
156Abnormality of the renal cortex (HP:0011035)1.06463640
157Abnormality of the distal phalanges of the toes (HP:0010182)1.02911353
158Hand muscle atrophy (HP:0009130)0.99771430
159Retinitis pigmentosa (HP:0000510)0.99272727
160Hyponatremia (HP:0002902)0.98658469
161Narrow forehead (HP:0000341)0.97846521
162Facial cleft (HP:0002006)0.95133807
163Prominent nasal bridge (HP:0000426)0.93887943
164Renal dysplasia (HP:0000110)0.93242933

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST45.56517002
2PDK44.97370001
3PDK34.97370001
4EPHA24.26464124
5TESK13.56369215
6PDK23.03168163
7MAP4K12.83860636
8STK102.58327279
9EEF2K2.45386992
10ERN12.24939495
11BCR2.16466491
12TRIB32.12611267
13NEK22.06817654
14MAP3K22.04675117
15TTN2.00349829
16NME11.93020819
17TTK1.92395171
18MAP3K101.89911372
19TEC1.76853100
20ICK1.75110909
21LRRK21.71597408
22PRKD31.70155623
23PTK2B1.69093611
24CSK1.68364904
25BTK1.66793188
26PKN21.59416336
27ZAP701.55191011
28ITK1.53341142
29RPS6KA41.48829333
30TGFBR21.47849405
31EPHB11.44871706
32KDR1.43822884
33BLK1.34813141
34MAPK151.27542955
35SMG11.25817127
36NEK61.24781768
37RIPK11.16906574
38TBK11.15533741
39STK31.15126855
40TRPM71.11476890
41MST1R1.11220619
42MAP3K71.10080740
43HCK1.08424889
44KIT1.06658922
45ERBB31.05377903
46CDK121.03953103
47TESK21.02099494
48TYK21.01449342
49MAP2K31.01205559
50PAK40.98764029
51GRK60.98490322
52BRSK20.98466650
53PTK60.97686646
54DYRK1B0.95995538
55CDC70.94033321
56TLK10.91088888
57MAP3K40.90144272
58IRAK40.87449974
59TIE10.87264900
60PIM10.85074385
61CLK10.84700816
62JAK30.84570824
63MARK20.84154796
64DYRK30.81012237
65CSF1R0.79609030
66STK38L0.78341616
67PASK0.78108944
68PAK20.77802511
69WEE10.77146472
70STK380.75453293
71LATS10.75345233
72ERBB20.74711831
73WNK40.74527736
74TXK0.74174101
75PTK20.71824466
76CAMKK10.70399591
77PRKCI0.69036509
78MAPKAPK30.67796548
79TGFBR10.67170890
80FGFR40.66105689
81JAK10.65110192
82LCK0.64245755
83PDK10.64101878
84MAP3K30.62148026
85MAP3K120.61742655
86CDK40.60866904
87CDK90.60264351
88MET0.58160535
89PIM20.57570636
90NLK0.56431595
91DMPK0.56361520
92MARK30.55875806
93MAPKAPK20.55377146
94IKBKE0.54832694
95SYK0.53994912
96EPHA40.53092048
97MAP2K60.52657729
98ATR0.51995761
99PRKG20.51958263
100PNCK0.49368968
101MTOR0.49353677
102RIPK40.48758621
103STK160.47390484
104MAP3K80.47010116
105IRAK10.46958264
106LMTK20.46780151
107INSRR0.46166453
108GRK10.45298390
109RPS6KB20.44034504
110AURKA0.44014706
111FLT30.43602803
112MAP2K70.43371732
113FER0.43278855
114SGK10.42939935
115STK240.42122324
116IKBKB0.41920355
117TAOK10.41732870
118FRK0.41558195
119EPHA30.41492584
120NEK90.41016366
121PBK0.40644195
122PDGFRB0.39812894
123LYN0.39112490
124MAP3K140.37592860
125STK40.37575723
126CDK60.36387037
127CAMK2G0.36261430
128TSSK60.35451117
129FGFR30.35309788
130MAP2K40.34572533
131PRKAA20.34383199
132PRKCD0.34246253
133MOS0.34196032
134DYRK1A0.34098260
135CHEK10.33604327
136FGR0.32318335
137STK390.32085057
138PRKCQ0.31705542
139EGFR0.30441191
140RPS6KA60.29243242
141ABL10.29069513
142PLK10.28789190
143PAK10.28097925
144MAPK130.27794433
145OXSR10.27492370
146ROCK20.27395531
147ROCK10.26816183
148SGK20.25300268
149RET0.24282109
150MUSK0.24107378
151HIPK20.22686699
152PDPK10.22457022
153SGK4940.22259551
154SGK2230.22259551
155AKT20.22245073
156ACVR1B0.22062578
157BMPR1B0.21995339
158PRKACA0.21347013
159PRKCA0.19513220
160MAPKAPK50.19135369
161ADRBK10.18832519
162NTRK30.18744525
163CDC42BPA0.17423421
164CAMK2A0.17253678
165PRKDC0.17194495
166FYN0.16779379
167SRC0.16332884
168TNIK0.14444350
169PRKCZ0.14036097
170CCNB10.13246613
171MAPK100.13076480

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009805.47878504
2Phenylalanine metabolism_Homo sapiens_hsa003604.75824572
3Histidine metabolism_Homo sapiens_hsa003404.57972635
4Chemical carcinogenesis_Homo sapiens_hsa052044.45090918
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.32049426
6Tyrosine metabolism_Homo sapiens_hsa003503.63398338
7Huntingtons disease_Homo sapiens_hsa050163.11891137
8beta-Alanine metabolism_Homo sapiens_hsa004103.06314932
9Glutathione metabolism_Homo sapiens_hsa004802.45439515
10Antigen processing and presentation_Homo sapiens_hsa046122.32611623
11Caffeine metabolism_Homo sapiens_hsa002322.31368397
12Retinol metabolism_Homo sapiens_hsa008302.25258841
13B cell receptor signaling pathway_Homo sapiens_hsa046622.15431213
14Primary immunodeficiency_Homo sapiens_hsa053402.08234310
15Leishmaniasis_Homo sapiens_hsa051402.01554578
16Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.94354622
17Linoleic acid metabolism_Homo sapiens_hsa005911.86836873
18ABC transporters_Homo sapiens_hsa020101.84400419
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.78167293
20Osteoclast differentiation_Homo sapiens_hsa043801.77128311
21Measles_Homo sapiens_hsa051621.75776173
22Leukocyte transendothelial migration_Homo sapiens_hsa046701.74525927
23DNA replication_Homo sapiens_hsa030301.72387760
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.67585755
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.66781246
26Sphingolipid metabolism_Homo sapiens_hsa006001.64940362
27Toxoplasmosis_Homo sapiens_hsa051451.58831247
28Tight junction_Homo sapiens_hsa045301.56556345
29Shigellosis_Homo sapiens_hsa051311.56317645
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.53722034
31Hematopoietic cell lineage_Homo sapiens_hsa046401.50668358
32Viral myocarditis_Homo sapiens_hsa054161.48994573
33Glycosaminoglycan degradation_Homo sapiens_hsa005311.48304289
34T cell receptor signaling pathway_Homo sapiens_hsa046601.48120171
35Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.47580689
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.43910185
37Pentose phosphate pathway_Homo sapiens_hsa000301.42868031
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.42260424
39p53 signaling pathway_Homo sapiens_hsa041151.41154578
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.37380192
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.36934929
42Legionellosis_Homo sapiens_hsa051341.34865389
43Fanconi anemia pathway_Homo sapiens_hsa034601.33374005
44Small cell lung cancer_Homo sapiens_hsa052221.29642949
45Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.29105079
46Herpes simplex infection_Homo sapiens_hsa051681.28904514
47Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.26930817
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.23761045
49Salmonella infection_Homo sapiens_hsa051321.23656478
50Fatty acid degradation_Homo sapiens_hsa000711.23068739
51Cell cycle_Homo sapiens_hsa041101.22594002
52Malaria_Homo sapiens_hsa051441.22403513
53HTLV-I infection_Homo sapiens_hsa051661.22348577
54Dorso-ventral axis formation_Homo sapiens_hsa043201.21527146
55Viral carcinogenesis_Homo sapiens_hsa052031.18952972
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.18748587
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.18496909
58Salivary secretion_Homo sapiens_hsa049701.17394063
59Intestinal immune network for IgA production_Homo sapiens_hsa046721.16391960
60TNF signaling pathway_Homo sapiens_hsa046681.14204925
61Basal transcription factors_Homo sapiens_hsa030221.12991526
62Peroxisome_Homo sapiens_hsa041461.12945365
63VEGF signaling pathway_Homo sapiens_hsa043701.11645053
64Chronic myeloid leukemia_Homo sapiens_hsa052201.09362100
65Hepatitis B_Homo sapiens_hsa051611.09293283
66Epstein-Barr virus infection_Homo sapiens_hsa051691.07078188
67Circadian rhythm_Homo sapiens_hsa047101.06828451
68Influenza A_Homo sapiens_hsa051641.06652759
69Transcriptional misregulation in cancer_Homo sapiens_hsa052021.04668431
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.03766466
71Focal adhesion_Homo sapiens_hsa045101.03467155
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.01620941
73Acute myeloid leukemia_Homo sapiens_hsa052211.01371363
74Platelet activation_Homo sapiens_hsa046111.01122924
75Apoptosis_Homo sapiens_hsa042101.00252380
76Hedgehog signaling pathway_Homo sapiens_hsa043400.99612393
77RNA transport_Homo sapiens_hsa030130.98727834
78ECM-receptor interaction_Homo sapiens_hsa045120.97916371
79NOD-like receptor signaling pathway_Homo sapiens_hsa046210.97862382
80Starch and sucrose metabolism_Homo sapiens_hsa005000.96439134
81Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94447696
82Adherens junction_Homo sapiens_hsa045200.94436664
83Base excision repair_Homo sapiens_hsa034100.93411581
84Arachidonic acid metabolism_Homo sapiens_hsa005900.91582851
85Vitamin B6 metabolism_Homo sapiens_hsa007500.90256030
86Basal cell carcinoma_Homo sapiens_hsa052170.88679841
87Mismatch repair_Homo sapiens_hsa034300.87767437
88Pancreatic cancer_Homo sapiens_hsa052120.86834379
89Proteoglycans in cancer_Homo sapiens_hsa052050.85855827
90Toll-like receptor signaling pathway_Homo sapiens_hsa046200.85493079
91Glucagon signaling pathway_Homo sapiens_hsa049220.85229950
92Staphylococcus aureus infection_Homo sapiens_hsa051500.82943703
93Homologous recombination_Homo sapiens_hsa034400.82538976
94MicroRNAs in cancer_Homo sapiens_hsa052060.81479997
95Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80030563
96Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.79281809
97mRNA surveillance pathway_Homo sapiens_hsa030150.79127897
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78568139
99Notch signaling pathway_Homo sapiens_hsa043300.78037905
100Non-homologous end-joining_Homo sapiens_hsa034500.77662517
101Bladder cancer_Homo sapiens_hsa052190.76776064
102Olfactory transduction_Homo sapiens_hsa047400.76619407
103Endocytosis_Homo sapiens_hsa041440.76129340
104Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.75845515
105Tuberculosis_Homo sapiens_hsa051520.75764243
106Choline metabolism in cancer_Homo sapiens_hsa052310.75329092
107Taste transduction_Homo sapiens_hsa047420.73339936
108Selenocompound metabolism_Homo sapiens_hsa004500.72360270
109Spliceosome_Homo sapiens_hsa030400.72096114
110Primary bile acid biosynthesis_Homo sapiens_hsa001200.71119471
111Pertussis_Homo sapiens_hsa051330.70521952
112RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.69987191
113Chemokine signaling pathway_Homo sapiens_hsa040620.69016701
114Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67742889
115Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66837293
116Nicotine addiction_Homo sapiens_hsa050330.66106128
117Amoebiasis_Homo sapiens_hsa051460.66061501
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65639395
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65619628
120N-Glycan biosynthesis_Homo sapiens_hsa005100.63277199
121Systemic lupus erythematosus_Homo sapiens_hsa053220.63099819
122Other glycan degradation_Homo sapiens_hsa005110.62969926
123Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62482737
124Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61551130
125Nucleotide excision repair_Homo sapiens_hsa034200.60225169
126Adipocytokine signaling pathway_Homo sapiens_hsa049200.60011541
127HIF-1 signaling pathway_Homo sapiens_hsa040660.59797942
128Allograft rejection_Homo sapiens_hsa053300.58492125
129Graft-versus-host disease_Homo sapiens_hsa053320.58235849
130Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58213229
131Pyruvate metabolism_Homo sapiens_hsa006200.58171235
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.58105392
133Drug metabolism - other enzymes_Homo sapiens_hsa009830.57446681
134Insulin resistance_Homo sapiens_hsa049310.56492463
135Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56357270
136Pathways in cancer_Homo sapiens_hsa052000.55875137
137Phototransduction_Homo sapiens_hsa047440.52801113
138Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52587252
139Hepatitis C_Homo sapiens_hsa051600.52191627
140Hippo signaling pathway_Homo sapiens_hsa043900.51365111
141Complement and coagulation cascades_Homo sapiens_hsa046100.50603763
142Pyrimidine metabolism_Homo sapiens_hsa002400.49914976
143Neurotrophin signaling pathway_Homo sapiens_hsa047220.49444384
144Estrogen signaling pathway_Homo sapiens_hsa049150.49198178
145Cocaine addiction_Homo sapiens_hsa050300.48873491
146Central carbon metabolism in cancer_Homo sapiens_hsa052300.48256317
147cAMP signaling pathway_Homo sapiens_hsa040240.43860828
148PPAR signaling pathway_Homo sapiens_hsa033200.42406374
149Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39166700
150Collecting duct acid secretion_Homo sapiens_hsa049660.37717887
151Arginine and proline metabolism_Homo sapiens_hsa003300.37102152
152Serotonergic synapse_Homo sapiens_hsa047260.34220055
153Axon guidance_Homo sapiens_hsa043600.32053535
154Pancreatic secretion_Homo sapiens_hsa049720.31546536
155Bile secretion_Homo sapiens_hsa049760.30197377
156Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30128608
157Amphetamine addiction_Homo sapiens_hsa050310.29311352
158Glycerolipid metabolism_Homo sapiens_hsa005610.28409376
159Melanogenesis_Homo sapiens_hsa049160.27775600
160Metabolic pathways_Homo sapiens_hsa011000.26319241
161Tryptophan metabolism_Homo sapiens_hsa003800.26079497
162Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.25442933
163Calcium signaling pathway_Homo sapiens_hsa040200.23974876
164Nitrogen metabolism_Homo sapiens_hsa009100.23666665
165Phosphatidylinositol signaling system_Homo sapiens_hsa040700.22599623
166Wnt signaling pathway_Homo sapiens_hsa043100.21193949
167Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.20111018
168Vitamin digestion and absorption_Homo sapiens_hsa049770.20057950
169Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.19724690
170Gastric acid secretion_Homo sapiens_hsa049710.19236427
171Fatty acid biosynthesis_Homo sapiens_hsa000610.18926554
172Regulation of autophagy_Homo sapiens_hsa041400.17875989
173Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.16634481
174Sphingolipid signaling pathway_Homo sapiens_hsa040710.16271038
175Prostate cancer_Homo sapiens_hsa052150.15421715
176Butanoate metabolism_Homo sapiens_hsa006500.13503340
177Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.12941445
178Lysosome_Homo sapiens_hsa041420.11217705
179Dilated cardiomyopathy_Homo sapiens_hsa054140.10562290
180Ovarian steroidogenesis_Homo sapiens_hsa049130.08240862
181Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.06922372
182Mineral absorption_Homo sapiens_hsa049780.05119710
183Phagosome_Homo sapiens_hsa041450.03700927
184alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.03575548

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