CFAP44

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1motile cilium assembly (GO:0044458)9.56966466
2axoneme assembly (GO:0035082)9.43539301
3fusion of sperm to egg plasma membrane (GO:0007342)8.07111923
4sperm motility (GO:0030317)7.96764137
5ventricular system development (GO:0021591)7.48387757
6multicellular organism reproduction (GO:0032504)6.95743612
7acrosome reaction (GO:0007340)6.80573135
8acrosome assembly (GO:0001675)6.65273666
9sperm-egg recognition (GO:0035036)6.43911049
10regulation of cilium movement (GO:0003352)6.43030383
11piRNA metabolic process (GO:0034587)6.35477755
12plasma membrane fusion (GO:0045026)6.28911627
13cell wall macromolecule catabolic process (GO:0016998)6.28010159
14cell wall macromolecule metabolic process (GO:0044036)6.28010159
15intraciliary transport (GO:0042073)6.07179168
16binding of sperm to zona pellucida (GO:0007339)5.83755351
17spermatid development (GO:0007286)5.80874747
18cell-cell recognition (GO:0009988)5.72014466
19primary alcohol catabolic process (GO:0034310)5.67927582
20nucleoside diphosphate phosphorylation (GO:0006165)5.62803828
21reproduction (GO:0000003)5.60546012
22GTP biosynthetic process (GO:0006183)5.54834503
23left/right axis specification (GO:0070986)5.46854326
24male meiosis (GO:0007140)5.41273909
25cilium organization (GO:0044782)5.40365363
26vitamin transmembrane transport (GO:0035461)5.25346092
27cilium assembly (GO:0042384)5.17978357
28single fertilization (GO:0007338)5.17708407
29ethanol metabolic process (GO:0006067)5.12102316
30diterpenoid biosynthetic process (GO:0016102)4.97347561
31protein localization to cilium (GO:0061512)4.93379284
32synaptonemal complex organization (GO:0070193)4.75234185
33UTP biosynthetic process (GO:0006228)4.70695426
34cilium morphogenesis (GO:0060271)4.65235413
35cellular component assembly involved in morphogenesis (GO:0010927)4.52351581
36negative regulation of inclusion body assembly (GO:0090084)4.48914325
37microtubule bundle formation (GO:0001578)4.48490549
38regulation of interleukin-5 production (GO:0032674)4.41057071
39microtubule-based movement (GO:0007018)4.37321849
40fertilization (GO:0009566)4.34664776
41left/right pattern formation (GO:0060972)4.30564237
42UTP metabolic process (GO:0046051)4.27663922
43microtubule severing (GO:0051013)4.25678685
44sperm capacitation (GO:0048240)4.22680984
45lung epithelium development (GO:0060428)4.20744639
46male meiosis I (GO:0007141)4.19216283
47DNA methylation involved in gamete generation (GO:0043046)4.18527298
48centriole assembly (GO:0098534)3.95471916
49synaptonemal complex assembly (GO:0007130)3.95256147
50spermatogenesis (GO:0007283)3.94893466
51tolerance induction (GO:0002507)3.93649658
52male gamete generation (GO:0048232)3.92823683
53negative regulation of B cell mediated immunity (GO:0002713)3.91490143
54negative regulation of immunoglobulin mediated immune response (GO:0002890)3.91490143
55ethanol oxidation (GO:0006069)3.91024501
56regulation of microtubule-based movement (GO:0060632)3.90539339
57pyrimidine-containing compound transmembrane transport (GO:0072531)3.82490307
58regulation of interleukin-13 production (GO:0032656)3.81093730
59glomerular epithelial cell development (GO:0072310)3.73977604
60negative regulation of humoral immune response (GO:0002921)3.73661160
61regulation of inclusion body assembly (GO:0090083)3.66058616
62response to xenobiotic stimulus (GO:0009410)3.63978731
63calcium ion-dependent exocytosis (GO:0017156)3.63209723
64gamete generation (GO:0007276)3.62520101
65cytoplasmic microtubule organization (GO:0031122)3.61142961
66centriole replication (GO:0007099)3.57110530
67establishment of apical/basal cell polarity (GO:0035089)3.55983015
68meiotic cell cycle (GO:0051321)3.54326644
69guanosine-containing compound biosynthetic process (GO:1901070)3.53702826
70cell projection assembly (GO:0030031)3.53246335
71spermatid nucleus differentiation (GO:0007289)3.51334553
72CTP biosynthetic process (GO:0006241)3.41820692
73CTP metabolic process (GO:0046036)3.41820692
74regulation of germinal center formation (GO:0002634)3.38257514
75microtubule polymerization or depolymerization (GO:0031109)3.37463689
76cell recognition (GO:0008037)3.34966464
77retinoic acid metabolic process (GO:0042573)3.32187750
78terpenoid biosynthetic process (GO:0016114)3.31425342
79negative regulation of T cell differentiation in thymus (GO:0033085)3.27794350
80germ cell development (GO:0007281)3.27627376
81positive regulation of tolerance induction (GO:0002645)3.26879543
82cellular process involved in reproduction in multicellular organism (GO:0022412)3.18557822
83protein polyglutamylation (GO:0018095)3.16955963
84establishment of tissue polarity (GO:0007164)3.14130405
85establishment of planar polarity (GO:0001736)3.14130405
86nucleotide phosphorylation (GO:0046939)3.13706805
87positive regulation of smoothened signaling pathway (GO:0045880)3.13307156
88establishment or maintenance of monopolar cell polarity (GO:0061339)3.10587407
89establishment of monopolar cell polarity (GO:0061162)3.10587407
90retinal rod cell development (GO:0046548)3.06081063
91meiosis I (GO:0007127)3.04798723
92pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.94319623
93smoothened signaling pathway (GO:0007224)2.91459671
94lateral sprouting from an epithelium (GO:0060601)2.90111320
95multicellular organismal reproductive process (GO:0048609)2.88593392
96meiotic nuclear division (GO:0007126)2.86074490
97brain morphogenesis (GO:0048854)2.85099016
98O-glycan processing (GO:0016266)2.83804962
99retinol metabolic process (GO:0042572)2.83454130
100negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.80591771
101exogenous drug catabolic process (GO:0042738)2.80168526
102determination of left/right symmetry (GO:0007368)2.78807397
103pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.78031163
104organic cation transport (GO:0015695)2.73135747
105pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.73069482
106nucleoside diphosphate metabolic process (GO:0009132)2.72962535
107microtubule depolymerization (GO:0007019)2.72538468
108chromosome organization involved in meiosis (GO:0070192)2.71860986
109determination of bilateral symmetry (GO:0009855)2.70951223
110primary alcohol metabolic process (GO:0034308)2.70528241
111photoreceptor cell maintenance (GO:0045494)2.69764124
112specification of symmetry (GO:0009799)2.65062292
113appendage development (GO:0048736)2.64277951
114limb development (GO:0060173)2.64277951
115phosphatidylcholine biosynthetic process (GO:0006656)2.57605016
116regulation of smoothened signaling pathway (GO:0008589)2.55681614
117organelle assembly (GO:0070925)2.52554295
118otic vesicle formation (GO:0030916)2.50059211
119apical protein localization (GO:0045176)2.49300791
120spinal cord motor neuron differentiation (GO:0021522)2.48859452
121eye photoreceptor cell differentiation (GO:0001754)2.48155481
122photoreceptor cell differentiation (GO:0046530)2.48155481
123regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.44861262
124regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.44487284
125microtubule-based process (GO:0007017)2.41023863
126regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.40298878
127ADP metabolic process (GO:0046031)2.39910281
128retinal cone cell development (GO:0046549)2.39147677
129heart looping (GO:0001947)2.38458039
130drug catabolic process (GO:0042737)2.38246372
131one-carbon compound transport (GO:0019755)2.36595625
132phosphatidylethanolamine biosynthetic process (GO:0006646)2.36499610
133multicellular organismal water homeostasis (GO:0050891)2.35247337
134lateral ventricle development (GO:0021670)2.33670614
135regulation of tolerance induction (GO:0002643)2.33292971
136establishment of nucleus localization (GO:0040023)2.32372938
137pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.32113909
138glutathione derivative metabolic process (GO:1901685)2.30693473
139glutathione derivative biosynthetic process (GO:1901687)2.30693473
140carnitine transmembrane transport (GO:1902603)2.30072309
141nonmotile primary cilium assembly (GO:0035058)2.29358921
142hydrogen peroxide biosynthetic process (GO:0050665)2.29245383
143regulation of centriole replication (GO:0046599)2.28545765
144positive regulation of meiosis (GO:0045836)2.25439669
145seminiferous tubule development (GO:0072520)2.24414828
146iron ion import (GO:0097286)2.24408014
147negative regulation of organelle assembly (GO:1902116)2.23661897
148hypotonic response (GO:0006971)2.23134118
149cerebral cortex neuron differentiation (GO:0021895)2.21704027
150regulation of cilium assembly (GO:1902017)2.21305651
151phosphatidylethanolamine metabolic process (GO:0046337)2.21293930
152deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.20876960
153positive regulation of meiotic cell cycle (GO:0051446)2.18976657
154protein refolding (GO:0042026)2.18813850
155calcium ion import (GO:0070509)2.18351314
156negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.17333830
157multicellular organismal development (GO:0007275)2.13976731
158cilium or flagellum-dependent cell motility (GO:0001539)15.3909710
159axonemal dynein complex assembly (GO:0070286)13.4739154
160cilium movement (GO:0003341)13.2350215
161epithelial cilium movement (GO:0003351)11.6416642
162epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)10.4217664

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.82658665
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.37494797
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.99584468
4FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.86655953
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.83306683
6ESR1_20079471_ChIP-ChIP_T-47D_Human2.58001127
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.42977953
8GBX2_23144817_ChIP-Seq_PC3_Human2.28751298
9AHR_22903824_ChIP-Seq_MCF-7_Human2.22342725
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.15539651
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.14406241
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.13102796
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.12930175
14CBX2_27304074_Chip-Seq_ESCs_Mouse2.04125908
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.00755053
16CTBP2_25329375_ChIP-Seq_LNCAP_Human1.98132453
17ZNF217_24962896_ChIP-Seq_MCF-7_Human1.97960239
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.91708863
19PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.91161475
20RBPJ_22232070_ChIP-Seq_NCS_Mouse1.90821729
21FOXM1_26456572_ChIP-Seq_MCF-7_Human1.84431744
22PCGF2_27294783_Chip-Seq_NPCs_Mouse1.80036349
23SMAD4_21799915_ChIP-Seq_A2780_Human1.79769499
24AR_21572438_ChIP-Seq_LNCaP_Human1.76672158
25SUZ12_27294783_Chip-Seq_NPCs_Mouse1.76322292
26TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.74478866
27TRIM28_21343339_ChIP-Seq_HEK293_Human1.69403919
28RNF2_27304074_Chip-Seq_NSC_Mouse1.69026874
29TAF15_26573619_Chip-Seq_HEK293_Human1.67732612
30NFE2_27457419_Chip-Seq_LIVER_Mouse1.62320026
31REST_21632747_ChIP-Seq_MESCs_Mouse1.61322160
32ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.59718705
33FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.58550784
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.56659598
35TP53_18474530_ChIP-ChIP_U2OS_Human1.55816933
36P300_19829295_ChIP-Seq_ESCs_Human1.55737310
37EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.55277385
38GATA1_26923725_Chip-Seq_HPCs_Mouse1.54765235
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.54592681
40NANOG_18555785_Chip-Seq_ESCs_Mouse1.52695535
41RUNX1_27514584_Chip-Seq_MCF-7_Human1.51539362
42TP63_23658742_ChIP-Seq_EP156T_Human1.50454415
43SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46874843
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.45213249
45CTNNB1_20460455_ChIP-Seq_HCT116_Human1.45105488
46DROSHA_22980978_ChIP-Seq_HELA_Human1.44968323
47POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.42987206
48TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42987206
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42808930
50TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42745618
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.42626823
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.41809300
53P53_22387025_ChIP-Seq_ESCs_Mouse1.41429544
54EZH2_27294783_Chip-Seq_ESCs_Mouse1.41362190
55ESR1_21235772_ChIP-Seq_MCF-7_Human1.40818151
56TAL1_26923725_Chip-Seq_HPCs_Mouse1.39679961
57SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.39309746
58ESR2_21235772_ChIP-Seq_MCF-7_Human1.38163901
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.37291568
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.36932252
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36772059
62ER_23166858_ChIP-Seq_MCF-7_Human1.36603966
63SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.36445588
64KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.35981388
65TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.35148071
66E2F1_18555785_Chip-Seq_ESCs_Mouse1.34378816
67MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34296595
68AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.34089253
69TCF4_23295773_ChIP-Seq_U87_Human1.32777844
70EZH2_27294783_Chip-Seq_NPCs_Mouse1.32315180
71STAT3_18555785_Chip-Seq_ESCs_Mouse1.31377165
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31200469
73SUZ12_27294783_Chip-Seq_ESCs_Mouse1.31194461
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31182339
75CMYC_18555785_Chip-Seq_ESCs_Mouse1.31173886
76FOXA1_25552417_ChIP-Seq_VCAP_Human1.30595103
77MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.30222219
78EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.29779952
79SUZ12_18555785_Chip-Seq_ESCs_Mouse1.29768239
80FUS_26573619_Chip-Seq_HEK293_Human1.29495182
81P300_18555785_Chip-Seq_ESCs_Mouse1.28777202
82STAT3_23295773_ChIP-Seq_U87_Human1.28459797
83OCT4_18555785_Chip-Seq_ESCs_Mouse1.27606423
84EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.26714155
85VDR_22108803_ChIP-Seq_LS180_Human1.26310686
86SMRT_27268052_Chip-Seq_Bcells_Human1.26282636
87KDM2B_26808549_Chip-Seq_REH_Human1.25620755
88PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24707117
89NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24000117
90SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.23202478
91ELK4_26923725_Chip-Seq_MESODERM_Mouse1.22886163
92EZH2_27304074_Chip-Seq_ESCs_Mouse1.22278220
93SOX2_18555785_Chip-Seq_ESCs_Mouse1.22053854
94KLF5_25053715_ChIP-Seq_YYC3_Human1.21626123
95ETV1_20927104_ChIP-Seq_GIST48_Human1.19998064
96CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19939570
97TP53_16413492_ChIP-PET_HCT116_Human1.19894561
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18966185
99TCF4_22108803_ChIP-Seq_LS180_Human1.18855110
100SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.18682617
101CBP_20019798_ChIP-Seq_JUKART_Human1.18609987
102IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18609987
103PIAS1_25552417_ChIP-Seq_VCAP_Human1.18343516
104BCAT_22108803_ChIP-Seq_LS180_Human1.17988719
105SOX9_24532713_ChIP-Seq_HFSC_Mouse1.17965119
106TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.17183414
107SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.17033945
108MTF2_20144788_ChIP-Seq_MESCs_Mouse1.17028010
109UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16975841
110RNF2_27304074_Chip-Seq_ESCs_Mouse1.16009772
111SOX2_27498859_Chip-Seq_STOMACH_Mouse1.15690252
112CRX_20693478_ChIP-Seq_RETINA_Mouse1.15669568
113FOXA2_19822575_ChIP-Seq_HepG2_Human1.15099627
114CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.14865661
115CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14391481
116ZFX_18555785_Chip-Seq_ESCs_Mouse1.14331022
117ESRRB_18555785_Chip-Seq_ESCs_Mouse1.14101536
118AR_25329375_ChIP-Seq_VCAP_Human1.14069907
119SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.13668560
120PU1_27457419_Chip-Seq_LIVER_Mouse1.13433034
121TBL1_22424771_ChIP-Seq_293T_Human1.13123871
122JARID2_20064375_ChIP-Seq_MESCs_Mouse1.12954202
123KLF4_18555785_Chip-Seq_ESCs_Mouse1.12763917
124RUNX1_27457419_Chip-Seq_LIVER_Mouse1.12683201
125ARNT_22903824_ChIP-Seq_MCF-7_Human1.12365592
126BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12265100
127CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12033852
128STAT1_20625510_ChIP-Seq_HELA_Human1.11969424
129WDR5_24793694_ChIP-Seq_LNCAP_Human1.11350824
130PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.10382239
131NMYC_18555785_Chip-Seq_ESCs_Mouse1.10011819
132RUNX2_22187159_ChIP-Seq_PCA_Human1.09955526
133EED_16625203_ChIP-ChIP_MESCs_Mouse1.09201103
134FOXO3_23340844_ChIP-Seq_DLD1_Human1.09055062
135PRDM14_20953172_ChIP-Seq_ESCs_Human1.08961291
136PHF8_20622853_ChIP-Seq_HELA_Human1.06776120
137RXR_22108803_ChIP-Seq_LS180_Human1.05416171
138SMAD4_21741376_ChIP-Seq_EPCs_Human1.05261598
139SMC4_20622854_ChIP-Seq_HELA_Human1.04137231
140HNFA_21074721_ChIP-Seq_CACO-2_Human1.03925990
141TDRD3_21172665_ChIP-Seq_MCF-7_Human1.03222875
142SMAD3_21741376_ChIP-Seq_HESCs_Human1.00789735
143ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98701713
144FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.98429005
145CBX2_22325352_ChIP-Seq_293T-Rex_Human0.97806382
146CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.97325529
147SALL1_21062744_ChIP-ChIP_HESCs_Human0.97011113
148AR_19668381_ChIP-Seq_PC3_Human0.96509993
149NFYB_21822215_ChIP-Seq_K562_Human0.95365425
150SMAD4_21741376_ChIP-Seq_HESCs_Human0.94911394
151NFYA_21822215_ChIP-Seq_K562_Human0.93970978
152PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93313468
153PPAR_26484153_Chip-Seq_NCI-H1993_Human0.93162228
154CDX2_22108803_ChIP-Seq_LS180_Human0.92431488
155VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.92388590
156STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.90997569
157TP63_22573176_ChIP-Seq_HFKS_Human0.90444220
158GATA4_25053715_ChIP-Seq_YYC3_Human0.90441768

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.43842209
2MP0008875_abnormal_xenobiotic_pharmacok5.16374135
3MP0002132_abnormal_respiratory_system4.71850725
4MP0003136_yellow_coat_color4.12493810
5MP0009780_abnormal_chondrocyte_physiolo3.92703737
6MP0002653_abnormal_ependyma_morphology3.75653510
7MP0003698_abnormal_male_reproductive3.72665881
8MP0004043_abnormal_pH_regulation3.53866105
9MP0000383_abnormal_hair_follicle3.27033448
10MP0001984_abnormal_olfaction3.23098245
11MP0001929_abnormal_gametogenesis3.13800804
12MP0005623_abnormal_meninges_morphology2.90845371
13MP0008877_abnormal_DNA_methylation2.80243732
14MP0010678_abnormal_skin_adnexa2.68352994
15MP0005646_abnormal_pituitary_gland2.48548980
16MP0009046_muscle_twitch2.41426922
17MP0008789_abnormal_olfactory_epithelium2.36311277
18MP0002210_abnormal_sex_determination2.25205336
19MP0003880_abnormal_central_pattern2.17701265
20MP0002160_abnormal_reproductive_system2.15072159
21MP0004859_abnormal_synaptic_plasticity2.09829811
22MP0002168_other_aberrant_phenotype1.91827796
23MP0002161_abnormal_fertility/fecundity1.91408068
24MP0005248_abnormal_Harderian_gland1.81990546
25MP0009745_abnormal_behavioral_response1.75149995
26MP0001486_abnormal_startle_reflex1.74693214
27MP0002282_abnormal_trachea_morphology1.74567294
28MP0004133_heterotaxia1.73499203
29MP0002102_abnormal_ear_morphology1.71337187
30MP0001145_abnormal_male_reproductive1.71239451
31MP0003635_abnormal_synaptic_transmissio1.67406778
32MP0004019_abnormal_vitamin_homeostasis1.65150171
33MP0008004_abnormal_stomach_pH1.64147680
34MP0001440_abnormal_grooming_behavior1.61847799
35MP0005083_abnormal_biliary_tract1.59627640
36MP0000778_abnormal_nervous_system1.57953956
37MP0008995_early_reproductive_senescence1.57707383
38MP0001968_abnormal_touch/_nociception1.57379436
39MP0002736_abnormal_nociception_after1.56948020
40MP0002572_abnormal_emotion/affect_behav1.55929141
41MP0000653_abnormal_sex_gland1.54901585
42MP0001501_abnormal_sleep_pattern1.49573984
43MP0002064_seizures1.45779289
44MP0005503_abnormal_tendon_morphology1.42365149
45MP0002063_abnormal_learning/memory/cond1.41426469
46MP0002735_abnormal_chemical_nociception1.38993606
47MP0005423_abnormal_somatic_nervous1.37877580
48MP0002928_abnormal_bile_duct1.36931441
49MP0002557_abnormal_social/conspecific_i1.36603598
50MP0006292_abnormal_olfactory_placode1.36034182
51MP0004742_abnormal_vestibular_system1.35647781
52MP0003656_abnormal_erythrocyte_physiolo1.32533191
53MP0001346_abnormal_lacrimal_gland1.31768059
54MP0002734_abnormal_mechanical_nocicepti1.27697113
55MP0003878_abnormal_ear_physiology1.26975053
56MP0005377_hearing/vestibular/ear_phenot1.26975053
57MP0002272_abnormal_nervous_system1.26903700
58MP0005551_abnormal_eye_electrophysiolog1.23985330
59MP0001177_atelectasis1.23261941
60MP0005389_reproductive_system_phenotype1.22986210
61MP0005645_abnormal_hypothalamus_physiol1.20505314
62MP0003122_maternal_imprinting1.18946918
63MP0002067_abnormal_sensory_capabilities1.17693946
64MP0005647_abnormal_sex_gland1.15223386
65MP0005670_abnormal_white_adipose1.15191479
66MP0001299_abnormal_eye_distance/1.13213938
67MP0002233_abnormal_nose_morphology1.12916081
68MP0002638_abnormal_pupillary_reflex1.09933015
69MP0002249_abnormal_larynx_morphology1.09625583
70MP0006276_abnormal_autonomic_nervous1.09120693
71MP0002909_abnormal_adrenal_gland1.08987351
72MP0002876_abnormal_thyroid_physiology1.03602911
73MP0000026_abnormal_inner_ear1.03043744
74MP0000566_synostosis1.02434566
75MP0005310_abnormal_salivary_gland1.01310011
76MP0001270_distended_abdomen1.00058725
77MP0001188_hyperpigmentation0.97833277
78MP0002009_preneoplasia0.97491898
79MP0003950_abnormal_plasma_membrane0.97228158
80MP0005395_other_phenotype0.96524217
81MP0004858_abnormal_nervous_system0.95919643
82MP0001502_abnormal_circadian_rhythm0.94399152
83MP0003634_abnormal_glial_cell0.92994305
84MP0001879_abnormal_lymphatic_vessel0.92748205
85MP0002234_abnormal_pharynx_morphology0.91574385
86MP0002938_white_spotting0.91567042
87MP0000631_abnormal_neuroendocrine_gland0.91449946
88MP0003942_abnormal_urinary_system0.91090427
89MP0001963_abnormal_hearing_physiology0.90898098
90MP0005220_abnormal_exocrine_pancreas0.89721751
91MP0002152_abnormal_brain_morphology0.88536341
92MP0003690_abnormal_glial_cell0.88402695
93MP0002882_abnormal_neuron_morphology0.88179452
94MP0001485_abnormal_pinna_reflex0.87602583
95MP0002752_abnormal_somatic_nervous0.84913229
96MP0000678_abnormal_parathyroid_gland0.83686040
97MP0005388_respiratory_system_phenotype0.83667684
98MP0002133_abnormal_respiratory_system0.83667684
99MP0005187_abnormal_penis_morphology0.83280261
100MP0000427_abnormal_hair_cycle0.81984656
101MP0005174_abnormal_tail_pigmentation0.80292295
102MP0002184_abnormal_innervation0.79672165
103MP0005253_abnormal_eye_physiology0.79390318
104MP0000681_abnormal_thyroid_gland0.79254545
105MP0003633_abnormal_nervous_system0.78967097
106MP0005391_vision/eye_phenotype0.78290471
107MP0000569_abnormal_digit_pigmentation0.77989915
108MP0010234_abnormal_vibrissa_follicle0.77963045
109MP0005164_abnormal_response_to0.76619148
110MP0003937_abnormal_limbs/digits/tail_de0.76370620
111MP0004270_analgesia0.76237890
112MP0005636_abnormal_mineral_homeostasis0.75901491
113MP0001970_abnormal_pain_threshold0.75463025
114MP0003045_fibrosis0.75425480
115MP0002277_abnormal_respiratory_mucosa0.75318102
116MP0000955_abnormal_spinal_cord0.75186961
117MP0004264_abnormal_extraembryonic_tissu0.75037268
118MP0004883_abnormal_blood_vessel0.74861320
119MP0002116_abnormal_craniofacial_bone0.73577730
120MP0004885_abnormal_endolymph0.73227056
121MP0002822_catalepsy0.73109743
122MP0003787_abnormal_imprinting0.72863592
123MP0001944_abnormal_pancreas_morphology0.72175630
124MP0004782_abnormal_surfactant_physiolog0.71827872
125MP0003861_abnormal_nervous_system0.71799195
126MP0003938_abnormal_ear_development0.71168533
127MP0001986_abnormal_taste_sensitivity0.71069348
128MP0010155_abnormal_intestine_physiology0.70438598
129MP0003866_abnormal_defecation0.70013066
130MP0004811_abnormal_neuron_physiology0.69748235
131MP0003943_abnormal_hepatobiliary_system0.69257163
132MP0005167_abnormal_blood-brain_barrier0.68727328
133MP0000049_abnormal_middle_ear0.68403465
134MP0009250_abnormal_appendicular_skeleto0.68001525
135MP0002108_abnormal_muscle_morphology0.67563069
136MP0005171_absent_coat_pigmentation0.66905884
137MP0002098_abnormal_vibrissa_morphology0.66668570
138MP0004381_abnormal_hair_follicle0.65918652
139MP0003879_abnormal_hair_cell0.65332968
140MP0001324_abnormal_eye_pigmentation0.64578899
141MP0005195_abnormal_posterior_eye0.63201128
142MP0005499_abnormal_olfactory_system0.63060615
143MP0005394_taste/olfaction_phenotype0.63060615
144MP0008569_lethality_at_weaning0.62296772
145MP0001765_abnormal_ion_homeostasis0.61851654
146MP0003631_nervous_system_phenotype0.61757666
147MP0002229_neurodegeneration0.61204087
148MP0008961_abnormal_basal_metabolism0.60915662
149MP0002136_abnormal_kidney_physiology0.60021352
150MP0005085_abnormal_gallbladder_physiolo0.58703386
151MP0001664_abnormal_digestion0.58272539
152MP0009643_abnormal_urine_homeostasis0.55660679
153MP0002405_respiratory_system_inflammati0.55545317
154MP0005408_hypopigmentation0.54887435
155MP0003252_abnormal_bile_duct0.54513956
156MP0009703_decreased_birth_body0.53175247
157MP0000534_abnormal_ureter_morphology0.53111212
158MP0000613_abnormal_salivary_gland0.52833600

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)9.97341449
2Absent/shortened dynein arms (HP:0200106)9.97341449
3Abnormal respiratory epithelium morphology (HP:0012253)9.38840385
4Abnormal respiratory motile cilium morphology (HP:0005938)9.38840385
5Rhinitis (HP:0012384)9.03327998
6Chronic bronchitis (HP:0004469)6.61924044
7Bronchiectasis (HP:0002110)5.28053185
8Nasal polyposis (HP:0100582)4.63937337
9Nephronophthisis (HP:0000090)4.23690390
10Infertility (HP:0000789)4.11287585
11Pancreatic fibrosis (HP:0100732)3.80545540
12Abnormality of the nasal mucosa (HP:0000433)3.73901086
13True hermaphroditism (HP:0010459)3.72287576
14Tubulointerstitial nephritis (HP:0001970)3.65809139
15Bronchitis (HP:0012387)3.46546830
16Recurrent sinusitis (HP:0011108)3.44018801
17Abnormality of the renal medulla (HP:0100957)3.38285226
18Abnormality of midbrain morphology (HP:0002418)3.32929609
19Molar tooth sign on MRI (HP:0002419)3.32929609
20Chronic sinusitis (HP:0011109)3.31820912
21Medial flaring of the eyebrow (HP:0010747)3.14452359
22Chronic otitis media (HP:0000389)2.86507232
23Postaxial foot polydactyly (HP:0001830)2.81554159
24Congenital hepatic fibrosis (HP:0002612)2.72729008
25Hyperactive renin-angiotensin system (HP:0000841)2.72416858
26Occipital encephalocele (HP:0002085)2.72237704
27Median cleft lip (HP:0000161)2.71979411
28Supernumerary spleens (HP:0009799)2.69718958
29Gait imbalance (HP:0002141)2.68974433
30Cystic liver disease (HP:0006706)2.63940659
31Congenital primary aphakia (HP:0007707)2.63136079
32Pancreatic cysts (HP:0001737)2.60118797
33Chronic hepatic failure (HP:0100626)2.58226634
34Recurrent otitis media (HP:0000403)2.53579143
35Fibular hypoplasia (HP:0003038)2.48503448
36Nephrogenic diabetes insipidus (HP:0009806)2.41129094
37Abnormality of dentin (HP:0010299)2.37450825
38Aplasia/Hypoplasia of the tongue (HP:0010295)2.37246208
39Tubulointerstitial abnormality (HP:0001969)2.35012156
40Bile duct proliferation (HP:0001408)2.27986507
41Abnormal biliary tract physiology (HP:0012439)2.27986507
42Stage 5 chronic kidney disease (HP:0003774)2.25209905
43Genital tract atresia (HP:0001827)2.19881790
44Tubular atrophy (HP:0000092)2.17635261
45Abnormality of the dental root (HP:0006486)2.15223976
46Taurodontia (HP:0000679)2.15223976
47Abnormality of permanent molar morphology (HP:0011071)2.15223976
48Postaxial hand polydactyly (HP:0001162)2.13592844
49Facial cleft (HP:0002006)2.12571167
50Vaginal atresia (HP:0000148)2.09223681
51Abnormality of molar morphology (HP:0011070)2.06213327
52Abnormality of molar (HP:0011077)2.06213327
53Abnormality of the dental pulp (HP:0006479)2.01818854
54Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.3750556
55Abnormal respiratory motile cilium physiology (HP:0012261)11.1768765
56Abnormal ciliary motility (HP:0012262)10.7434736
57Poor coordination (HP:0002370)1.99440848
58Preaxial hand polydactyly (HP:0001177)1.94084500
59Hyperkalemia (HP:0002153)1.89441802
60Male infertility (HP:0003251)1.87961159
61Oculomotor apraxia (HP:0000657)1.82912491
62Male pseudohermaphroditism (HP:0000037)1.77391796
63Decreased circulating renin level (HP:0003351)1.77255800
64Abnormality of the renal cortex (HP:0011035)1.70652563
65Aplasia/Hypoplasia of the lens (HP:0008063)1.70370180
66Polydipsia (HP:0001959)1.68069498
67Abnormal drinking behavior (HP:0030082)1.68069498
68Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.66875858
69Anencephaly (HP:0002323)1.66538749
70Bell-shaped thorax (HP:0001591)1.65530477
71Renal salt wasting (HP:0000127)1.62742339
72Renal dysplasia (HP:0000110)1.61830868
73Asplenia (HP:0001746)1.58874519
74Aplasia/Hypoplasia of the spleen (HP:0010451)1.58028111
75Aplasia/Hypoplasia of the fibula (HP:0006492)1.57732253
76Decreased central vision (HP:0007663)1.55029209
77Nephropathy (HP:0000112)1.52950460
78Bifid tongue (HP:0010297)1.51802591
79Sclerocornea (HP:0000647)1.47647572
80Cone-rod dystrophy (HP:0000548)1.42357918
81Tubulointerstitial fibrosis (HP:0005576)1.41839029
82Absent rod-and cone-mediated responses on ERG (HP:0007688)1.40428396
83Atelectasis (HP:0100750)1.40139851
84Hyperaldosteronism (HP:0000859)1.39545781
85Recurrent bronchitis (HP:0002837)1.36295354
86Abnormality of renin-angiotensin system (HP:0000847)1.32585547
87Abnormality of the frontal sinuses (HP:0002687)1.32381683
88Abnormality of renal excretion (HP:0011036)1.30787265
89Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.30477385
90Abnormality of chloride homeostasis (HP:0011422)1.30230890
91Polycystic kidney dysplasia (HP:0000113)1.29451055
92Short ribs (HP:0000773)1.29367734
93Gonadotropin excess (HP:0000837)1.29336773
94Glucose intolerance (HP:0000833)1.27405020
95Short thorax (HP:0010306)1.26546941
96Absent frontal sinuses (HP:0002688)1.24491142
97Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.24481714
98Progressive cerebellar ataxia (HP:0002073)1.23994661
99Furrowed tongue (HP:0000221)1.23494052
100Abnormal rod and cone electroretinograms (HP:0008323)1.23466540
101Specific learning disability (HP:0001328)1.22663126
102Short nail (HP:0001799)1.22270173
103Hip dysplasia (HP:0001385)1.21951018
104Broad distal phalanx of finger (HP:0009836)1.20869986
105Hypotelorism (HP:0000601)1.20806632
106Focal motor seizures (HP:0011153)1.18938173
107Hypodontia (HP:0000668)1.16988423
108Aganglionic megacolon (HP:0002251)1.16702077
109Bifid scrotum (HP:0000048)1.15512352
110Lip pit (HP:0100267)1.14904600
111Narrow chest (HP:0000774)1.14675904
112Gaze-evoked nystagmus (HP:0000640)1.14434245
113Abnormality of macular pigmentation (HP:0008002)1.14351812
114Hypokalemic alkalosis (HP:0001949)1.13930424
115Retinitis pigmentosa (HP:0000510)1.13746565
116Narrow forehead (HP:0000341)1.13331279
117Omphalocele (HP:0001539)1.13114235
118Abnormality of abdominal situs (HP:0011620)1.13111969
119Abdominal situs inversus (HP:0003363)1.13111969
120Microglossia (HP:0000171)1.12061950
12111 pairs of ribs (HP:0000878)1.11509236
122Neoplasm of the heart (HP:0100544)1.06636656
123Prominent nasal bridge (HP:0000426)1.05832886
124Down-sloping shoulders (HP:0200021)1.04463707
125Bony spicule pigmentary retinopathy (HP:0007737)0.99479002

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK36.00194003
2PDK46.00194003
3MAPK154.54213310
4PNCK4.45055016
5PDK24.15555457
6EPHA23.04825367
7NME12.75459216
8PRKD32.24943877
9TESK12.08185545
10CASK2.05663799
11MAPKAPK32.01704954
12PTK2B1.88082957
13NTRK21.85083885
14NTRK31.76608328
15MAP3K21.73237190
16ICK1.61515117
17LMTK21.51774326
18MAP2K71.50535817
19MAP3K71.50269256
20TNIK1.49893269
21NEK61.49209599
22BRSK21.43389403
23IRAK11.34574884
24MARK11.29796040
25ERBB31.25694623
26MST1R1.25608441
27GRK11.23723091
28STK391.23303366
29STK241.22622131
30CDK31.12211277
31EPHA31.11562896
32PLK21.09842884
33ADRBK21.09544722
34WNK41.09529275
35EPHA41.09505683
36SGK21.08027633
37ERBB21.05798601
38MAP3K41.05329686
39PRKCG1.01152448
40STK380.98554544
41MUSK0.98538997
42MAPK130.98214294
43MST40.97062448
44CSK0.96270913
45WNK10.94447419
46DAPK20.91840948
47MARK20.89098834
48EEF2K0.86438216
49EPHB10.86369625
50PHKG20.86324988
51PHKG10.86324988
52TIE10.86200804
53PRPF4B0.79709137
54IRAK20.79291507
55NLK0.78749667
56SGK4940.78461488
57SGK2230.78461488
58TSSK60.78329380
59CAMK1G0.76004723
60PINK10.75918577
61YES10.74562761
62ACVR1B0.74444861
63GRK70.73241326
64STK38L0.73058039
65NEK90.72083909
66MINK10.70233196
67SIK30.69035762
68WEE10.66924727
69DYRK1A0.66858225
70BMPR20.64952169
71MAP3K120.64077246
72TLK10.63443771
73STK30.62459782
74MAP3K30.62041715
75SGK30.61900537
76STK100.61449589
77INSRR0.61236161
78GRK50.61008195
79FGFR30.60186616
80CAMK2A0.60058647
81CAMKK10.58730150
82PRKCQ0.58551161
83MKNK20.57577817
84PRKG10.56699422
85ZAK0.55325130
86RIPK40.54562690
87TBK10.52923867
88LRRK20.52682933
89MAP2K20.52026790
90PRKCE0.51567094
91RET0.51469638
92AKT30.51070691
93PLK40.50110382
94HIPK20.49377649
95TTK0.49355835
96MET0.49215129
97RPS6KA20.47876743
98MAP4K20.47225204
99BCR0.46251733
100DYRK1B0.44406618
101ROCK10.43119165
102CDK50.42228435
103MELK0.41432972
104PRKAA20.40707419
105MAP3K100.40216256
106GRK60.40120366
107BMPR1B0.39005532
108PDPK10.38994610
109WNK30.38635420
110PRKCI0.38282179
111TYRO30.36189353
112PKN10.35209252
113BRD40.35122271
114STK110.34951543
115MAP3K60.34820348
116JAK10.33853650
117TRIB30.33616787
118PDK10.33319267
119CAMK2B0.33014184
120CAMKK20.32493023
121PAK30.31628629
122FER0.31382484
123MAP2K40.31012628
124PDGFRB0.30996904
125CDK120.30950540
126VRK10.30719006
127TNK20.30393216
128CCNB10.29967732
129PRKACA0.29646532
130PRKCZ0.28667375
131CHUK0.28613377
132TRPM70.28519260
133DYRK30.27858525
134RPS6KB10.27828201
135ADRBK10.27461766
136ABL10.26794182
137TEC0.26633538
138CDK60.26027824
139FRK0.25479803
140MAP2K10.25451224
141MAPKAPK50.25169422
142MAPK100.25114114
143FGFR20.25099751
144RPS6KA30.24759509
145LATS10.24742268
146PAK60.24258766
147MYLK0.23906413
148ROCK20.23789320
149NUAK10.23144039
150PRKACG0.23091430
151MAPK70.22854164
152PAK20.22816716
153CDC42BPA0.22549101
154EIF2AK20.22159379
155SGK10.22136717

Predicted pathways (KEGG)

RankGene SetZ-score
1Chemical carcinogenesis_Homo sapiens_hsa052043.68451700
2Phenylalanine metabolism_Homo sapiens_hsa003603.37445602
3Nicotine addiction_Homo sapiens_hsa050333.25563338
4Olfactory transduction_Homo sapiens_hsa047403.24721865
5Vitamin B6 metabolism_Homo sapiens_hsa007502.74679846
6Tyrosine metabolism_Homo sapiens_hsa003502.66446640
7beta-Alanine metabolism_Homo sapiens_hsa004102.33716252
8Taste transduction_Homo sapiens_hsa047422.26071617
9Amphetamine addiction_Homo sapiens_hsa050312.11693962
10Dorso-ventral axis formation_Homo sapiens_hsa043202.00810743
11Circadian entrainment_Homo sapiens_hsa047131.98775553
12Huntingtons disease_Homo sapiens_hsa050161.95400917
13Glutamatergic synapse_Homo sapiens_hsa047241.92685123
14Morphine addiction_Homo sapiens_hsa050321.83274757
15Fatty acid biosynthesis_Homo sapiens_hsa000611.76960039
16Synaptic vesicle cycle_Homo sapiens_hsa047211.76422167
17Calcium signaling pathway_Homo sapiens_hsa040201.75667107
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.72538223
19GABAergic synapse_Homo sapiens_hsa047271.68926513
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.67159474
21Gastric acid secretion_Homo sapiens_hsa049711.62973494
22Caffeine metabolism_Homo sapiens_hsa002321.62651510
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.61910377
24Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.59427926
25Renin secretion_Homo sapiens_hsa049241.58107467
26Salivary secretion_Homo sapiens_hsa049701.54805827
27Insulin secretion_Homo sapiens_hsa049111.52641131
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48465981
29Glutathione metabolism_Homo sapiens_hsa004801.47017531
30Collecting duct acid secretion_Homo sapiens_hsa049661.42666669
31Notch signaling pathway_Homo sapiens_hsa043301.39675923
32Long-term potentiation_Homo sapiens_hsa047201.36928333
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.36215285
34Glucagon signaling pathway_Homo sapiens_hsa049221.35953823
35Hedgehog signaling pathway_Homo sapiens_hsa043401.34524164
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.33430526
37Ether lipid metabolism_Homo sapiens_hsa005651.31888380
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.29409830
39Fanconi anemia pathway_Homo sapiens_hsa034601.28425160
40cAMP signaling pathway_Homo sapiens_hsa040241.27455743
41Mineral absorption_Homo sapiens_hsa049781.26703010
42Pyruvate metabolism_Homo sapiens_hsa006201.25865062
43Phototransduction_Homo sapiens_hsa047441.25338572
44Ovarian steroidogenesis_Homo sapiens_hsa049131.23098538
45Tight junction_Homo sapiens_hsa045301.21379918
46Serotonergic synapse_Homo sapiens_hsa047261.20776740
47Linoleic acid metabolism_Homo sapiens_hsa005911.15654461
48Cocaine addiction_Homo sapiens_hsa050301.15490411
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.13892095
50Cardiac muscle contraction_Homo sapiens_hsa042601.12465601
51Choline metabolism in cancer_Homo sapiens_hsa052311.09627440
52Dopaminergic synapse_Homo sapiens_hsa047281.09469136
53Arachidonic acid metabolism_Homo sapiens_hsa005901.09272312
54Basal transcription factors_Homo sapiens_hsa030221.08814694
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.08549736
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.06762114
57Basal cell carcinoma_Homo sapiens_hsa052171.01781651
58Fatty acid degradation_Homo sapiens_hsa000711.01646002
59Glycerophospholipid metabolism_Homo sapiens_hsa005640.97288031
60Axon guidance_Homo sapiens_hsa043600.97228755
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96794856
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96206767
63Wnt signaling pathway_Homo sapiens_hsa043100.95896350
64Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.94815200
65Aldosterone synthesis and secretion_Homo sapiens_hsa049250.90873116
66Sphingolipid metabolism_Homo sapiens_hsa006000.90515204
67Circadian rhythm_Homo sapiens_hsa047100.90149488
68Oocyte meiosis_Homo sapiens_hsa041140.88833139
69Thyroid hormone synthesis_Homo sapiens_hsa049180.88109797
70Estrogen signaling pathway_Homo sapiens_hsa049150.88038847
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.86476135
72Rheumatoid arthritis_Homo sapiens_hsa053230.84712539
73Nitrogen metabolism_Homo sapiens_hsa009100.84695535
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84607592
75Peroxisome_Homo sapiens_hsa041460.83382338
76Oxytocin signaling pathway_Homo sapiens_hsa049210.82548613
77ABC transporters_Homo sapiens_hsa020100.82403117
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82039795
79Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.81986618
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80485361
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.80163207
82Glycerolipid metabolism_Homo sapiens_hsa005610.79476033
83Inositol phosphate metabolism_Homo sapiens_hsa005620.78957750
84Glycosaminoglycan degradation_Homo sapiens_hsa005310.78266442
85Butanoate metabolism_Homo sapiens_hsa006500.76823200
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.75020384
87Purine metabolism_Homo sapiens_hsa002300.75006130
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73769738
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73249826
90Propanoate metabolism_Homo sapiens_hsa006400.72397605
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.72330296
92Melanogenesis_Homo sapiens_hsa049160.70831889
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69477536
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69146994
95Cholinergic synapse_Homo sapiens_hsa047250.69008332
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68657845
97Pancreatic secretion_Homo sapiens_hsa049720.65979819
98PPAR signaling pathway_Homo sapiens_hsa033200.63927853
99Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63426062
100Adherens junction_Homo sapiens_hsa045200.61514019
101Hepatitis C_Homo sapiens_hsa051600.60698658
102Vibrio cholerae infection_Homo sapiens_hsa051100.57863732
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56894048
104Maturity onset diabetes of the young_Homo sapiens_hsa049500.54316771
105Jak-STAT signaling pathway_Homo sapiens_hsa046300.53482255
106Complement and coagulation cascades_Homo sapiens_hsa046100.53056782
107Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50956445
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50900890
109Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50900049
110Prostate cancer_Homo sapiens_hsa052150.50144140
111Phagosome_Homo sapiens_hsa041450.49949271
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47787073
113Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46985386
114Hippo signaling pathway_Homo sapiens_hsa043900.46349300
115Starch and sucrose metabolism_Homo sapiens_hsa005000.45903579
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44732285
117Insulin resistance_Homo sapiens_hsa049310.42923492
118Regulation of autophagy_Homo sapiens_hsa041400.41661395
119GnRH signaling pathway_Homo sapiens_hsa049120.40642496
120MAPK signaling pathway_Homo sapiens_hsa040100.39672675
121Hematopoietic cell lineage_Homo sapiens_hsa046400.38878272
122Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38164461
123Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38146606
124Dilated cardiomyopathy_Homo sapiens_hsa054140.38044521
125Bile secretion_Homo sapiens_hsa049760.37801423
126Type II diabetes mellitus_Homo sapiens_hsa049300.37000308
127Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34499650
128Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33085777
129Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.32994490
130Retinol metabolism_Homo sapiens_hsa008300.32808810
131Autoimmune thyroid disease_Homo sapiens_hsa053200.32677358
132Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32636311
133Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31804481
134Type I diabetes mellitus_Homo sapiens_hsa049400.31672191
135Protein digestion and absorption_Homo sapiens_hsa049740.31589964
136Long-term depression_Homo sapiens_hsa047300.30265975
137Histidine metabolism_Homo sapiens_hsa003400.29562840
138Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.25317588
139Sphingolipid signaling pathway_Homo sapiens_hsa040710.24372683

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