CFAP45

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.75511115
2axonemal dynein complex assembly (GO:0070286)8.50963601
3motile cilium assembly (GO:0044458)8.13777499
4cilium movement (GO:0003341)7.14313861
5epithelial cilium movement (GO:0003351)7.03013172
6primary alcohol catabolic process (GO:0034310)6.86275796
7microtubule bundle formation (GO:0001578)6.35414129
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.32931958
9polyketide metabolic process (GO:0030638)6.21490352
10doxorubicin metabolic process (GO:0044598)6.21490352
11daunorubicin metabolic process (GO:0044597)6.21490352
12fusion of sperm to egg plasma membrane (GO:0007342)6.20834167
13sperm motility (GO:0030317)6.16954269
14multicellular organism reproduction (GO:0032504)6.09928731
15vitamin transmembrane transport (GO:0035461)5.96222402
16diterpenoid biosynthetic process (GO:0016102)5.81564862
17ethanol metabolic process (GO:0006067)5.73769913
18centriole assembly (GO:0098534)5.61083129
19acrosome reaction (GO:0007340)5.44888973
20cell wall macromolecule catabolic process (GO:0016998)5.28056765
21cell wall macromolecule metabolic process (GO:0044036)5.28056765
22tolerance induction (GO:0002507)5.18364551
23piRNA metabolic process (GO:0034587)5.16510244
24sperm-egg recognition (GO:0035036)5.15458935
25acrosome assembly (GO:0001675)4.97055316
26regulation of microtubule-based movement (GO:0060632)4.91736322
27one-carbon compound transport (GO:0019755)4.90177951
28pyrimidine-containing compound transmembrane transport (GO:0072531)4.81520218
29regulation of cilium movement (GO:0003352)4.78406076
30reproduction (GO:0000003)4.72141010
31glomerular epithelial cell development (GO:0072310)4.68766278
32plasma membrane fusion (GO:0045026)4.66003132
33microtubule-based movement (GO:0007018)4.64952061
34cell-cell recognition (GO:0009988)4.63885672
35negative regulation of inclusion body assembly (GO:0090084)4.63760928
36negative regulation of B cell mediated immunity (GO:0002713)4.63132721
37negative regulation of immunoglobulin mediated immune response (GO:0002890)4.63132721
38response to xenobiotic stimulus (GO:0009410)4.62906800
39lung epithelium development (GO:0060428)4.55735056
40negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.53680011
41establishment of apical/basal cell polarity (GO:0035089)4.52210428
42regulation of interleukin-5 production (GO:0032674)4.51321754
43axoneme assembly (GO:0035082)4.50088582
44centriole replication (GO:0007099)4.46704192
45binding of sperm to zona pellucida (GO:0007339)4.46036482
46male meiosis (GO:0007140)4.44205757
47ethanol oxidation (GO:0006069)4.41271666
48spermatid development (GO:0007286)4.38651849
49negative regulation of T cell differentiation in thymus (GO:0033085)4.33636790
50negative regulation of humoral immune response (GO:0002921)4.32419181
51microtubule polymerization or depolymerization (GO:0031109)4.25357305
52regulation of interleukin-13 production (GO:0032656)4.24257442
53DNA methylation involved in gamete generation (GO:0043046)4.17144257
54single fertilization (GO:0007338)4.16195153
55positive regulation of tolerance induction (GO:0002645)4.14505594
56ventricular system development (GO:0021591)4.10124669
57terpenoid biosynthetic process (GO:0016114)3.99547061
58regulation of germinal center formation (GO:0002634)3.98513024
59intraciliary transport (GO:0042073)3.92767814
60retinoic acid metabolic process (GO:0042573)3.88852069
61establishment of monopolar cell polarity (GO:0061162)3.87149702
62establishment or maintenance of monopolar cell polarity (GO:0061339)3.87149702
63microtubule depolymerization (GO:0007019)3.79644646
64cilium organization (GO:0044782)3.73690747
65cilium assembly (GO:0042384)3.72267521
66aminoglycoside antibiotic metabolic process (GO:0030647)3.70971707
67cytoplasmic microtubule organization (GO:0031122)3.56994848
68protein localization to cilium (GO:0061512)3.55300247
69establishment of planar polarity (GO:0001736)3.49243983
70establishment of tissue polarity (GO:0007164)3.49243983
71left/right axis specification (GO:0070986)3.42581719
72energy homeostasis (GO:0097009)3.35739906
73fertilization (GO:0009566)3.35245155
74sperm capacitation (GO:0048240)3.30978978
75lateral ventricle development (GO:0021670)3.27281616
76retinal rod cell development (GO:0046548)3.21190217
77detection of molecule of bacterial origin (GO:0032490)3.19156677
78regulation of tolerance induction (GO:0002643)3.17108624
79spermatogenesis (GO:0007283)3.17012005
80male meiosis I (GO:0007141)3.17006142
81male gamete generation (GO:0048232)3.15970072
82synaptonemal complex organization (GO:0070193)3.15945684
83retinol metabolic process (GO:0042572)3.10775658
84O-glycan processing (GO:0016266)3.10586784
85regulation of inclusion body assembly (GO:0090083)3.05366653
86GTP biosynthetic process (GO:0006183)3.03370604
87primary alcohol metabolic process (GO:0034308)3.01463218
88superoxide anion generation (GO:0042554)3.01202609
89gamete generation (GO:0007276)2.97034650
90cellular component assembly involved in morphogenesis (GO:0010927)2.95584468
91phosphatidylethanolamine biosynthetic process (GO:0006646)2.94563492
92meiotic cell cycle (GO:0051321)2.94378678
93positive regulation of smoothened signaling pathway (GO:0045880)2.89636914
94regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.88827863
95regulation of activation of Janus kinase activity (GO:0010533)2.88383969
96exogenous drug catabolic process (GO:0042738)2.88181549
97hydrogen peroxide biosynthetic process (GO:0050665)2.87215846
98synaptonemal complex assembly (GO:0007130)2.85039361
99positive regulation of cellular amide metabolic process (GO:0034250)2.81357841
100cilium morphogenesis (GO:0060271)2.81273730
101sulfate transmembrane transport (GO:1902358)2.80228538
102glutathione derivative biosynthetic process (GO:1901687)2.79523125
103glutathione derivative metabolic process (GO:1901685)2.79523125
104microtubule-based process (GO:0007017)2.73594540
105sulfate transport (GO:0008272)2.70037639
106phosphatidylethanolamine metabolic process (GO:0046337)2.70004838
107phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.69658817
108negative regulation of mast cell activation (GO:0033004)2.68958530
109sequestering of actin monomers (GO:0042989)2.67510007
110multicellular organismal water homeostasis (GO:0050891)2.67270687
111nucleoside diphosphate phosphorylation (GO:0006165)2.66189619
112lateral sprouting from an epithelium (GO:0060601)2.65912889
113chromosome organization involved in meiosis (GO:0070192)2.65820538
114auditory receptor cell stereocilium organization (GO:0060088)2.64550689
115synapsis (GO:0007129)2.64208181
116phosphatidylcholine biosynthetic process (GO:0006656)2.63299335
117nucleoside diphosphate catabolic process (GO:0009134)2.63024075
118determination of left/right symmetry (GO:0007368)2.62931864
119smoothened signaling pathway (GO:0007224)2.62907577
120germ cell development (GO:0007281)2.61740472
121organelle assembly (GO:0070925)2.59913589
122carnitine metabolic process (GO:0009437)2.58917063
123left/right pattern formation (GO:0060972)2.57688246
124hypotonic response (GO:0006971)2.55864921
125excretion (GO:0007588)2.55128595
126regulation of microtubule depolymerization (GO:0031114)2.55103197
127progesterone metabolic process (GO:0042448)2.53767913
128cellular process involved in reproduction in multicellular organism (GO:0022412)2.53623781
129detection of other organism (GO:0098543)2.53592621
130detection of external biotic stimulus (GO:0098581)2.53156854
131reactive oxygen species biosynthetic process (GO:1903409)2.53005113
132determination of bilateral symmetry (GO:0009855)2.51835697
133neutrophil activation involved in immune response (GO:0002283)2.49709408
134regulation of cilium assembly (GO:1902017)2.48436539
135replicative senescence (GO:0090399)2.48423590
136specification of symmetry (GO:0009799)2.47087146
137microtubule severing (GO:0051013)2.44872624
138meiotic nuclear division (GO:0007126)2.44341313
139apical protein localization (GO:0045176)2.43973180
140response to peptidoglycan (GO:0032494)2.42066697
141embryonic camera-type eye development (GO:0031076)2.41912543
142regulation of RIG-I signaling pathway (GO:0039535)2.41626907
143protein polyglutamylation (GO:0018095)2.38104494
144dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.37618460
145regulation of autophagic vacuole assembly (GO:2000785)2.37614158
146regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.36520318
147regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.36389724
148detection of bacterium (GO:0016045)2.33779392
149lipoxygenase pathway (GO:0019372)2.32927931
150cell projection assembly (GO:0030031)2.31770949
151meiosis I (GO:0007127)2.31206905
152nonmotile primary cilium assembly (GO:0035058)2.30633874
153regulation of spindle checkpoint (GO:0090231)2.30348795
154organic cation transport (GO:0015695)2.29863174
155inner ear receptor stereocilium organization (GO:0060122)2.28902002
156microglial cell activation (GO:0001774)2.28722142
157detection of biotic stimulus (GO:0009595)2.28600157
158positive regulation of CREB transcription factor activity (GO:0032793)2.28240985
159UTP biosynthetic process (GO:0006228)2.27756657
160regulation of centriole replication (GO:0046599)2.27062643
161multicellular organismal reproductive process (GO:0048609)2.26581967
162neutrophil activation (GO:0042119)2.25202834
163single strand break repair (GO:0000012)2.24896828
164DNA synthesis involved in DNA repair (GO:0000731)2.24237929
165regulation of mitotic spindle checkpoint (GO:1903504)2.22565901
166regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.22565901
167positive regulation of interleukin-1 beta secretion (GO:0050718)2.20617816
168regulation of dendritic cell antigen processing and presentation (GO:0002604)2.18019022
169dendritic cell chemotaxis (GO:0002407)2.17871496
170extracellular regulation of signal transduction (GO:1900115)2.15323389

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.86934161
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.72017937
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.50028243
4DROSHA_22980978_ChIP-Seq_HELA_Human3.30050032
5EZH2_22144423_ChIP-Seq_EOC_Human3.05142382
6FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.01590241
7PCGF2_27294783_Chip-Seq_ESCs_Mouse2.98387243
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.90863445
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.76911796
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.67106038
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.63702311
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.46771709
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.41987431
14SUZ12_27294783_Chip-Seq_NPCs_Mouse2.41707334
15NFE2_27457419_Chip-Seq_LIVER_Mouse2.36751860
16GBX2_23144817_ChIP-Seq_PC3_Human2.32071779
17PCGF2_27294783_Chip-Seq_NPCs_Mouse2.28396830
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.20773126
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.20124420
20IRF8_21731497_ChIP-ChIP_J774_Mouse2.18495549
21EZH2_27294783_Chip-Seq_NPCs_Mouse2.02409773
22ESR1_20079471_ChIP-ChIP_T-47D_Human2.00356400
23TRIM28_21343339_ChIP-Seq_HEK293_Human1.98391225
24SMC4_20622854_ChIP-Seq_HELA_Human1.98346626
25TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.96996055
26RUNX1_27514584_Chip-Seq_MCF-7_Human1.91586192
27EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.90453311
28NANOG_18555785_Chip-Seq_ESCs_Mouse1.88691105
29IRF8_22096565_ChIP-ChIP_GC-B_Human1.86367999
30P53_22387025_ChIP-Seq_ESCs_Mouse1.85415486
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.84616889
32STAT3_18555785_Chip-Seq_ESCs_Mouse1.84580088
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.82590196
34SUZ12_18555785_Chip-Seq_ESCs_Mouse1.82226980
35AHR_22903824_ChIP-Seq_MCF-7_Human1.78265821
36E2F1_18555785_Chip-Seq_ESCs_Mouse1.76336965
37RNF2_27304074_Chip-Seq_NSC_Mouse1.74184985
38ARNT_22903824_ChIP-Seq_MCF-7_Human1.73617766
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.73452118
40TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.72180170
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.71773848
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.70649373
43EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.70180694
44OCT4_18555785_Chip-Seq_ESCs_Mouse1.69653402
45CMYC_18555785_Chip-Seq_ESCs_Mouse1.68722999
46P300_18555785_Chip-Seq_ESCs_Mouse1.68595175
47STAT1_20625510_ChIP-Seq_HELA_Human1.68090031
48SOX2_27498859_Chip-Seq_STOMACH_Mouse1.66135597
49TAL1_26923725_Chip-Seq_HPCs_Mouse1.65104300
50FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.64466317
51KLF5_25053715_ChIP-Seq_YYC3_Human1.64413508
52ELF1_20517297_ChIP-Seq_JURKAT_Human1.64385436
53NMYC_18555785_Chip-Seq_ESCs_Mouse1.62926017
54VDR_22108803_ChIP-Seq_LS180_Human1.62313227
55TP63_22573176_ChIP-Seq_HFKS_Human1.62089842
56RUNX1_27457419_Chip-Seq_LIVER_Mouse1.61651624
57FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.61586070
58IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.61379252
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.59346941
60PU1_27457419_Chip-Seq_LIVER_Mouse1.57657566
61ZFX_18555785_Chip-Seq_ESCs_Mouse1.57129105
62SOX2_18555785_Chip-Seq_ESCs_Mouse1.56246684
63KLF4_18555785_Chip-Seq_ESCs_Mouse1.55918140
64TP63_23658742_ChIP-Seq_EP156T_Human1.54727479
65CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54550091
66PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.53443498
67ESRRB_18555785_Chip-Seq_ESCs_Mouse1.52674598
68P63_26484246_Chip-Seq_KERATINOCYTES_Human1.51202488
69TDRD3_21172665_ChIP-Seq_MCF-7_Human1.50567145
70ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.49570149
71TAF15_26573619_Chip-Seq_HEK293_Human1.49509014
72CRX_20693478_ChIP-Seq_RETINA_Mouse1.49424362
73P300_19829295_ChIP-Seq_ESCs_Human1.48301247
74ZNF217_24962896_ChIP-Seq_MCF-7_Human1.47176945
75KAP1_22055183_ChIP-Seq_ESCs_Mouse1.46554932
76CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.45582975
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.45497542
78MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45217082
79OCT4_21477851_ChIP-Seq_ESCs_Mouse1.44481540
80GATA1_19941826_ChIP-Seq_K562_Human1.42137452
81ER_23166858_ChIP-Seq_MCF-7_Human1.42006169
82SOX9_24532713_ChIP-Seq_HFSC_Mouse1.41471314
83SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.40872327
84CTCF_18555785_Chip-Seq_ESCs_Mouse1.40545249
85SMRT_27268052_Chip-Seq_Bcells_Human1.39474632
86PIAS1_25552417_ChIP-Seq_VCAP_Human1.39106305
87SMAD1_18555785_Chip-Seq_ESCs_Mouse1.38114012
88FUS_26573619_Chip-Seq_HEK293_Human1.36029117
89EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.35608223
90FOXM1_26456572_ChIP-Seq_MCF-7_Human1.35421632
91AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.35352004
92IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.34103391
93ESR1_21235772_ChIP-Seq_MCF-7_Human1.33260546
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32958682
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32958682
96CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.31933284
97SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31784253
98TP53_18474530_ChIP-ChIP_U2OS_Human1.31672483
99STAT6_21828071_ChIP-Seq_BEAS2B_Human1.31550671
100CTNNB1_20460455_ChIP-Seq_HCT116_Human1.31225118
101ETV1_20927104_ChIP-Seq_GIST48_Human1.30827168
102P68_20966046_ChIP-Seq_HELA_Human1.30457675
103RAD21_21589869_ChIP-Seq_MESCs_Mouse1.30138491
104IGF1R_20145208_ChIP-Seq_DFB_Human1.29155335
105CTCF_27219007_Chip-Seq_Bcells_Human1.27931773
106HNFA_21074721_ChIP-Seq_CACO-2_Human1.27826984
107CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.27391936
108YY1_22570637_ChIP-Seq_MALME-3M_Human1.26566611
109SMAD4_21799915_ChIP-Seq_A2780_Human1.26063969
110KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.25285658
111LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.24746463
112STAT1_17558387_ChIP-Seq_HELA_Human1.23905035
113SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.23734889
114CTCF_20526341_ChIP-Seq_ESCs_Human1.22537024
115IRF8_27001747_Chip-Seq_BMDM_Mouse1.22476976
116CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21671044
117PHF8_20622853_ChIP-Seq_HELA_Human1.20869946
118VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.20713390
119KDM2B_26808549_Chip-Seq_REH_Human1.20660078
120PHF8_20622854_ChIP-Seq_HELA_Human1.19375458
121Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.18954218
122PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17856585
123CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.17745598
124KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.15832250
125LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15813825
126ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.15400193
127PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.15083588
128GATA1_26923725_Chip-Seq_HPCs_Mouse1.14382130
129LXR_22292898_ChIP-Seq_THP-1_Human1.14052906
130RBPJ_21746931_ChIP-Seq_IB4_Human1.13585258
131FOXA1_25552417_ChIP-Seq_VCAP_Human1.13332066
132P300_27268052_Chip-Seq_Bcells_Human1.12461075
133PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11885253
134TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11769064
135FOXO3_23340844_ChIP-Seq_DLD1_Human1.09897398
136MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.09783914
137EWS_26573619_Chip-Seq_HEK293_Human1.09601849
138AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08686448
139PPAR_26484153_Chip-Seq_NCI-H1993_Human1.08489507
140CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08291988
141TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07527279
142TCF4_23295773_ChIP-Seq_U87_Human1.06685718
143CBX2_22325352_ChIP-Seq_293T-Rex_Human1.06677967
144CEBPB_22108803_ChIP-Seq_LS180_Human1.06612008
145STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.06509042
146SOX2_20726797_ChIP-Seq_SW620_Human1.06200060
147GF1_26923725_Chip-Seq_HPCs_Mouse1.05706088
148GATA6_21074721_ChIP-Seq_CACO-2_Human1.05456914
149CDX2_20551321_ChIP-Seq_CACO-2_Human1.05093636
150AR_21572438_ChIP-Seq_LNCaP_Human1.03812891
151NFYA_21822215_ChIP-Seq_K562_Human1.03321558
152CREB1_26743006_Chip-Seq_LNCaP_Human1.02320036
153GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.01376675
154BCOR_27268052_Chip-Seq_Bcells_Human1.01358780
155E2F1_20622854_ChIP-Seq_HELA_Human1.01107335
156CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00991429
157GATA2_19941826_ChIP-Seq_K562_Human1.00989723
158SMAD3_21741376_ChIP-Seq_EPCs_Human1.00475794
159RACK7_27058665_Chip-Seq_MCF-7_Human0.97745234
160GATA4_25053715_ChIP-Seq_YYC3_Human0.97490692
161STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.97242817
162EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.97149249
163UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97099558
164WDR5_24793694_ChIP-Seq_LNCAP_Human0.97087409
165SCL_19346495_ChIP-Seq_HPC-7_Human0.97067170
166CBP_20019798_ChIP-Seq_JUKART_Human0.96739228
167IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96739228
168FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.96261989
169TBL1_22424771_ChIP-Seq_293T_Human0.95196229
170RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.94521239
171BCL6_27268052_Chip-Seq_Bcells_Human0.94275375
172SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.93898973
173P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.93523821
174NOTCH1_21737748_ChIP-Seq_TLL_Human0.92599027
175EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.92088495
176FOXA2_19822575_ChIP-Seq_HepG2_Human0.90891345
177RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.90469465
178GF1B_26923725_Chip-Seq_HPCs_Mouse0.90164835
179STAT3_23295773_ChIP-Seq_U87_Human0.90078816
180AR_25329375_ChIP-Seq_VCAP_Human0.89899113
181SA1_27219007_Chip-Seq_ERYTHROID_Human0.89692198
182GATA3_24758297_ChIP-Seq_MCF-7_Human0.88347965
183MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88129373
184TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88017217
185KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.87781795
186ERG_20517297_ChIP-Seq_VCAP_Human0.87298983
187NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87023920
188NFYB_21822215_ChIP-Seq_K562_Human0.87017727
189SOX2_21211035_ChIP-Seq_LN229_Human0.86207307
190TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.85458052
191EZH2_27294783_Chip-Seq_ESCs_Mouse0.85380066
192SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.84684065
193RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.84377424

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok6.39821234
2MP0005410_abnormal_fertilization5.93887061
3MP0005623_abnormal_meninges_morphology3.79470859
4MP0006292_abnormal_olfactory_placode3.46976048
5MP0004043_abnormal_pH_regulation3.41378602
6MP0009780_abnormal_chondrocyte_physiolo3.35155380
7MP0004133_heterotaxia3.00650466
8MP0008004_abnormal_stomach_pH2.66821955
9MP0008877_abnormal_DNA_methylation2.62285684
10MP0003698_abnormal_male_reproductive2.57016553
11MP0001188_hyperpigmentation2.56709041
12MP0000566_synostosis2.51060572
13MP0003136_yellow_coat_color2.45293126
14MP0001835_abnormal_antigen_presentation2.44945819
15MP0002282_abnormal_trachea_morphology2.39914250
16MP0001929_abnormal_gametogenesis2.38183509
17MP0005083_abnormal_biliary_tract2.24067444
18MP0008058_abnormal_DNA_repair2.15826862
19MP0000383_abnormal_hair_follicle2.11425552
20MP0009785_altered_susceptibility_to2.11298894
21MP0001986_abnormal_taste_sensitivity2.06142088
22MP0002148_abnormal_hypersensitivity_rea2.05186656
23MP0004019_abnormal_vitamin_homeostasis2.02901596
24MP0002132_abnormal_respiratory_system1.99486050
25MP0002277_abnormal_respiratory_mucosa1.97724931
26MP0002168_other_aberrant_phenotype1.97333025
27MP0002210_abnormal_sex_determination1.88914294
28MP0010678_abnormal_skin_adnexa1.87864321
29MP0003656_abnormal_erythrocyte_physiolo1.87399897
30MP0005646_abnormal_pituitary_gland1.86433695
31MP0001765_abnormal_ion_homeostasis1.86162944
32MP0008057_abnormal_DNA_replication1.77603970
33MP0005671_abnormal_response_to1.76346456
34MP0005670_abnormal_white_adipose1.75229936
35MP0005409_darkened_coat_color1.72304795
36MP0003724_increased_susceptibility_to1.69913277
37MP0002160_abnormal_reproductive_system1.68620265
38MP0005248_abnormal_Harderian_gland1.65609998
39MP0005645_abnormal_hypothalamus_physiol1.63753202
40MP0000015_abnormal_ear_pigmentation1.63563400
41MP0005394_taste/olfaction_phenotype1.63419314
42MP0005499_abnormal_olfactory_system1.63419314
43MP0005171_absent_coat_pigmentation1.62670221
44MP0004782_abnormal_surfactant_physiolog1.58849962
45MP0009697_abnormal_copulation1.57064555
46MP0004381_abnormal_hair_follicle1.56004561
47MP0002249_abnormal_larynx_morphology1.52871585
48MP0003878_abnormal_ear_physiology1.51280672
49MP0005377_hearing/vestibular/ear_phenot1.51280672
50MP0005387_immune_system_phenotype1.50476247
51MP0001790_abnormal_immune_system1.50476247
52MP0003303_peritoneal_inflammation1.47991637
53MP0002163_abnormal_gland_morphology1.47354962
54MP0002102_abnormal_ear_morphology1.45173360
55MP0002419_abnormal_innate_immunity1.42859477
56MP0008995_early_reproductive_senescence1.40467392
57MP0001984_abnormal_olfaction1.40415525
58MP0005174_abnormal_tail_pigmentation1.36941336
59MP0005075_abnormal_melanosome_morpholog1.35890566
60MP0005395_other_phenotype1.32820057
61MP0005025_abnormal_response_to1.31068940
62MP0001145_abnormal_male_reproductive1.30084458
63MP0005000_abnormal_immune_tolerance1.27856342
64MP0002909_abnormal_adrenal_gland1.27585188
65MP0002876_abnormal_thyroid_physiology1.27461727
66MP0000653_abnormal_sex_gland1.27414833
67MP0002161_abnormal_fertility/fecundity1.26320545
68MP0000465_gastrointestinal_hemorrhage1.25643916
69MP0005164_abnormal_response_to1.24335600
70MP0002452_abnormal_antigen_presenting1.24158202
71MP0000569_abnormal_digit_pigmentation1.24098333
72MP0005165_increased_susceptibility_to1.24073063
73MP0005389_reproductive_system_phenotype1.22992180
74MP0010155_abnormal_intestine_physiology1.22747852
75MP0010234_abnormal_vibrissa_follicle1.22393976
76MP0002723_abnormal_immune_serum1.22378132
77MP0002822_catalepsy1.22260761
78MP0003763_abnormal_thymus_physiology1.22033289
79MP0010094_abnormal_chromosome_stability1.21874822
80MP0004742_abnormal_vestibular_system1.21693367
81MP0008007_abnormal_cellular_replicative1.21330885
82MP0002638_abnormal_pupillary_reflex1.19629475
83MP0000372_irregular_coat_pigmentation1.17406477
84MP0001800_abnormal_humoral_immune1.17307988
85MP0002405_respiratory_system_inflammati1.15884896
86MP0005647_abnormal_sex_gland1.14853856
87MP0003436_decreased_susceptibility_to1.13522590
88MP0005310_abnormal_salivary_gland1.13211665
89MP0002396_abnormal_hematopoietic_system1.12811544
90MP0001819_abnormal_immune_cell1.12285466
91MP0004883_abnormal_blood_vessel1.11530269
92MP0002420_abnormal_adaptive_immunity1.10528783
93MP0003787_abnormal_imprinting1.08927638
94MP0001873_stomach_inflammation1.08109623
95MP0005636_abnormal_mineral_homeostasis1.07882372
96MP0005379_endocrine/exocrine_gland_phen1.05780737
97MP0009764_decreased_sensitivity_to1.04093348
98MP0002938_white_spotting1.01791275
99MP0006082_CNS_inflammation1.00648532
100MP0000685_abnormal_immune_system0.98343078
101MP0001119_abnormal_female_reproductive0.98181884
102MP0002095_abnormal_skin_pigmentation0.96700069
103MP0002653_abnormal_ependyma_morphology0.96228185
104MP0002928_abnormal_bile_duct0.96040907
105MP0001485_abnormal_pinna_reflex0.95595086
106MP0003786_premature_aging0.94550153
107MP0001545_abnormal_hematopoietic_system0.91910923
108MP0005397_hematopoietic_system_phenotyp0.91910923
109MP0004264_abnormal_extraembryonic_tissu0.91229774
110MP0002735_abnormal_chemical_nociception0.90118640
111MP0010386_abnormal_urinary_bladder0.88610491
112MP0001849_ear_inflammation0.88544882
113MP0009765_abnormal_xenobiotic_induced0.87793308
114MP0002734_abnormal_mechanical_nocicepti0.86047334
115MP0008260_abnormal_autophagy0.84485603
116MP0000026_abnormal_inner_ear0.84219185
117MP0004808_abnormal_hematopoietic_stem0.84100821
118MP0003941_abnormal_skin_development0.83675648
119MP0005464_abnormal_platelet_physiology0.83209473
120MP0001346_abnormal_lacrimal_gland0.83054018
121MP0003879_abnormal_hair_cell0.83049214
122MP0003943_abnormal_hepatobiliary_system0.82188171
123MP0005408_hypopigmentation0.80815485
124MP0000716_abnormal_immune_system0.79249098
125MP0000678_abnormal_parathyroid_gland0.78021263
126MP0002398_abnormal_bone_marrow0.77548105
127MP0002136_abnormal_kidney_physiology0.76443641
128MP0000681_abnormal_thyroid_gland0.75780677
129MP0009643_abnormal_urine_homeostasis0.74756503
130MP0003453_abnormal_keratinocyte_physiol0.74153674
131MP0000470_abnormal_stomach_morphology0.74094636
132MP0001963_abnormal_hearing_physiology0.73474080
133MP0000490_abnormal_crypts_of0.70482409
134MP0002736_abnormal_nociception_after0.69383680
135MP0000049_abnormal_middle_ear0.69298591
136MP0001502_abnormal_circadian_rhythm0.68559308
137MP0001486_abnormal_startle_reflex0.68041215
138MP0002233_abnormal_nose_morphology0.66404654
139MP0000858_altered_metastatic_potential0.66111184
140MP0000467_abnormal_esophagus_morphology0.64825764
141MP0008789_abnormal_olfactory_epithelium0.64643094
142MP0002098_abnormal_vibrissa_morphology0.62663699
143MP0003075_altered_response_to0.62234000
144MP0010030_abnormal_orbit_morphology0.62228886
145MP0009763_increased_sensitivity_to0.62148137
146MP0005085_abnormal_gallbladder_physiolo0.60147592
147MP0001879_abnormal_lymphatic_vessel0.58888921
148MP0002133_abnormal_respiratory_system0.55682312
149MP0005388_respiratory_system_phenotype0.55682312
150MP0003866_abnormal_defecation0.55139673
151MP0000249_abnormal_blood_vessel0.54865389
152MP0005023_abnormal_wound_healing0.53723741
153MP0001270_distended_abdomen0.53395241
154MP0005166_decreased_susceptibility_to0.52522191
155MP0005365_abnormal_bile_salt0.51849110
156MP0001663_abnormal_digestive_system0.51633749
157MP0005253_abnormal_eye_physiology0.48733860
158MP0003091_abnormal_cell_migration0.47236476
159MP0001324_abnormal_eye_pigmentation0.47051476
160MP0009379_abnormal_foot_pigmentation0.46325850
161MP0002229_neurodegeneration0.45704027
162MP0001293_anophthalmia0.45150490
163MP0002896_abnormal_bone_mineralization0.44259435
164MP0003828_pulmonary_edema0.43656673
165MP0002135_abnormal_kidney_morphology0.43639493
166MP0002116_abnormal_craniofacial_bone0.39657157
167MP0000955_abnormal_spinal_cord0.39125666
168MP0001664_abnormal_digestion0.38923653
169MP0005220_abnormal_exocrine_pancreas0.37397611

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.62801129
2Absent/shortened dynein arms (HP:0200106)8.36748579
3Dynein arm defect of respiratory motile cilia (HP:0012255)8.36748579
4Abnormal respiratory motile cilium physiology (HP:0012261)7.33577551
5Abnormal ciliary motility (HP:0012262)6.95400291
6Abnormal respiratory epithelium morphology (HP:0012253)6.74251852
7Abnormal respiratory motile cilium morphology (HP:0005938)6.74251852
8Rhinitis (HP:0012384)5.97451671
9Chronic bronchitis (HP:0004469)4.15091185
10Bronchiectasis (HP:0002110)3.88834546
11Nephronophthisis (HP:0000090)3.54668717
12Pancreatic fibrosis (HP:0100732)3.49919541
13True hermaphroditism (HP:0010459)3.48150545
14Chromosomal breakage induced by crosslinking agents (HP:0003221)3.27333860
15Nasal polyposis (HP:0100582)3.25482690
16Infertility (HP:0000789)3.25366329
17Atelectasis (HP:0100750)3.16995967
18Hyperactive renin-angiotensin system (HP:0000841)3.00019699
19Abnormality of the renal medulla (HP:0100957)2.97490498
20Retrobulbar optic neuritis (HP:0100654)2.97452946
21Optic neuritis (HP:0100653)2.97452946
22Chronic otitis media (HP:0000389)2.95957411
23Chromsome breakage (HP:0040012)2.92716183
24Medial flaring of the eyebrow (HP:0010747)2.92213959
25Molar tooth sign on MRI (HP:0002419)2.90714458
26Abnormality of midbrain morphology (HP:0002418)2.90714458
27Tubulointerstitial nephritis (HP:0001970)2.90696761
28Pancreatic cysts (HP:0001737)2.73283938
29Median cleft lip (HP:0000161)2.73251896
30Recurrent sinusitis (HP:0011108)2.72765405
31Postaxial foot polydactyly (HP:0001830)2.65025394
32Bronchitis (HP:0012387)2.59917551
33Orchitis (HP:0100796)2.55447372
34Abnormality of the nasal mucosa (HP:0000433)2.54236367
35Bile duct proliferation (HP:0001408)2.45632071
36Abnormal biliary tract physiology (HP:0012439)2.45632071
37Occipital encephalocele (HP:0002085)2.41192444
38Bell-shaped thorax (HP:0001591)2.40059120
39Congenital hepatic fibrosis (HP:0002612)2.35251221
40Chronic sinusitis (HP:0011109)2.34663120
41Nephrogenic diabetes insipidus (HP:0009806)2.32128542
42Recurrent abscess formation (HP:0002722)2.30383501
43Supernumerary spleens (HP:0009799)2.28937730
44Chronic hepatic failure (HP:0100626)2.26994980
45Congenital primary aphakia (HP:0007707)2.26948846
46Myositis (HP:0100614)2.25696303
47Gait imbalance (HP:0002141)2.18313774
48Preaxial hand polydactyly (HP:0001177)2.17625862
49Decreased central vision (HP:0007663)2.16962621
50Abnormality of the renal collecting system (HP:0004742)2.10965643
51Male pseudohermaphroditism (HP:0000037)2.09836624
52Aplasia/Hypoplasia of the tongue (HP:0010295)2.09311716
53Duplicated collecting system (HP:0000081)2.08668799
54Prostate neoplasm (HP:0100787)2.08537763
55Cystic liver disease (HP:0006706)2.06138073
56Abnormality of the renal cortex (HP:0011035)2.04221681
57Recurrent otitis media (HP:0000403)2.03912085
58Abnormal spermatogenesis (HP:0008669)2.03203042
59Renal dysplasia (HP:0000110)2.03048826
60Clubbing of toes (HP:0100760)2.01525537
61Ectopic kidney (HP:0000086)1.95390936
62Abnormality of the preputium (HP:0100587)1.95118769
63Abnormality of molar (HP:0011077)1.95044289
64Abnormality of molar morphology (HP:0011070)1.95044289
65Poor coordination (HP:0002370)1.87139955
66Hyperkalemia (HP:0002153)1.85409970
67Aplasia/Hypoplasia of the uvula (HP:0010293)1.85325005
68Recurrent bacterial skin infections (HP:0005406)1.85103601
69Abnormality of permanent molar morphology (HP:0011071)1.85040491
70Abnormality of the dental root (HP:0006486)1.85040491
71Taurodontia (HP:0000679)1.85040491
72Renal salt wasting (HP:0000127)1.84080622
73Male infertility (HP:0003251)1.81700449
74Postaxial hand polydactyly (HP:0001162)1.79267690
75Abnormality of chromosome stability (HP:0003220)1.77553083
76Azoospermia (HP:0000027)1.75783553
77Tubulointerstitial abnormality (HP:0001969)1.74716247
78Type 2 muscle fiber atrophy (HP:0003554)1.74271878
79Keratoconjunctivitis sicca (HP:0001097)1.71447474
80Aplasia/Hypoplasia of the lens (HP:0008063)1.71014068
81Meckel diverticulum (HP:0002245)1.70196104
82Nephropathy (HP:0000112)1.69293253
83Decreased circulating renin level (HP:0003351)1.69224980
84Anencephaly (HP:0002323)1.69045838
85Recurrent pneumonia (HP:0006532)1.65228739
86Chronic obstructive pulmonary disease (HP:0006510)1.64467037
87Obstructive lung disease (HP:0006536)1.64467037
88Abnormality of the ileum (HP:0001549)1.64042115
89Facial cleft (HP:0002006)1.63379258
90Septo-optic dysplasia (HP:0100842)1.62401756
91Abnormality of the dental pulp (HP:0006479)1.62050274
92Abnormality of incisor morphology (HP:0011063)1.61522006
93Alveolar cell carcinoma (HP:0006519)1.61382700
94White forelock (HP:0002211)1.61014262
95Parakeratosis (HP:0001036)1.60743531
96Tubular atrophy (HP:0000092)1.60618172
97Keratoconjunctivitis (HP:0001096)1.59903864
98Increased IgM level (HP:0003496)1.58540682
99Short femoral neck (HP:0100864)1.58485806
100Sclerocornea (HP:0000647)1.56714295
101Recurrent bronchitis (HP:0002837)1.56468462
102Genital tract atresia (HP:0001827)1.56160101
103Eczematoid dermatitis (HP:0000976)1.55031885
104Optic nerve hypoplasia (HP:0000609)1.55027167
105Aganglionic megacolon (HP:0002251)1.54526297
106Patchy hypopigmentation of hair (HP:0011365)1.54246908
107Oculomotor apraxia (HP:0000657)1.54200699
108Absent frontal sinuses (HP:0002688)1.54084994
109Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.53993785
110Stage 5 chronic kidney disease (HP:0003774)1.53508420
111Cone-rod dystrophy (HP:0000548)1.52413134
112Asplenia (HP:0001746)1.50579676
113Aplasia/Hypoplasia of the spleen (HP:0010451)1.49801522
114Hyperaldosteronism (HP:0000859)1.47933002
115Absent rod-and cone-mediated responses on ERG (HP:0007688)1.45194658
116Abnormality of chloride homeostasis (HP:0011422)1.44728559
117Furrowed tongue (HP:0000221)1.44102230
118Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.42799359
119Abnormality of renin-angiotensin system (HP:0000847)1.29944024
120Hand muscle atrophy (HP:0009130)1.28699267
121Hypokalemic alkalosis (HP:0001949)1.27160291
122Hyponatremia (HP:0002902)1.25833334
123Short nail (HP:0001799)1.24536741
124Abnormal rod and cone electroretinograms (HP:0008323)1.21183697
125Short thorax (HP:0010306)1.20065830
126Glucose intolerance (HP:0000833)1.19694090
127Abnormality of the frontal sinuses (HP:0002687)1.12571907
128Bifid scrotum (HP:0000048)1.10745212
129Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.10732354
130Abnormality of the distal phalanges of the toes (HP:0010182)1.10573947
131Fetal akinesia sequence (HP:0001989)1.08992888
132Vaginal atresia (HP:0000148)1.05720878
133Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.05201286
134Abnormality of macular pigmentation (HP:0008002)1.03368974
135Polydipsia (HP:0001959)1.02272683
136Abnormal drinking behavior (HP:0030082)1.02272683
137Obstructive sleep apnea (HP:0002870)1.00267152
138Abnormality of dentin (HP:0010299)0.99042557
139Short ribs (HP:0000773)0.96150429
140Tubulointerstitial fibrosis (HP:0005576)0.95675480
141Abnormality of sodium homeostasis (HP:0010931)0.95536862
142Muscle fiber splitting (HP:0003555)0.93359682

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK33.43946964
2PDK32.62395983
3PDK42.62395983
4TXK2.60676021
5IRAK42.49912012
6PDK22.40532770
7MAP3K142.39280993
8PLK42.30707897
9BMPR22.28486852
10IRAK32.25493277
11MKNK22.21038145
12ZAK2.20394826
13MAP3K22.17513014
14CASK2.02311895
15MAPK151.95372814
16TNIK1.95306526
17SMG11.92282238
18NME11.90979735
19STK161.88731451
20ADRBK21.83603860
21CSK1.80496312
22EIF2AK21.79281549
23MAPKAPK31.79145281
24IRAK11.78208057
25YES11.74067903
26STK241.73346499
27MAP3K31.71109360
28MUSK1.59881306
29MAP2K71.55707524
30NEK61.53922263
31EPHB11.53603009
32CDK81.40499308
33ERBB31.39793639
34TEC1.37589482
35NUAK11.37092807
36EEF2K1.36067252
37CDK31.34125250
38GRK11.33390089
39MST1R1.32144281
40TESK11.25728527
41BMPR1B1.25416424
42IKBKE1.24633294
43GRK71.22180499
44IKBKB1.21068471
45MKNK11.20825376
46BLK1.20444231
47INSRR1.18422946
48LRRK21.16852933
49STK38L1.15568280
50VRK11.12395246
51STK101.11093258
52PINK11.10976473
53EPHA31.09263033
54MARK21.08189912
55MST41.05114118
56MAPK131.04075444
57IRAK21.03416597
58NLK1.02699049
59CLK11.01169243
60MAP3K71.00852691
61SRPK10.99473640
62SIK20.98385530
63SGK20.97684369
64PIM20.90515577
65ATR0.88058183
66BTK0.85810087
67CHUK0.80666127
68TIE10.80471019
69RIPK40.80133897
70TRPM70.79834114
71GRK60.76052991
72STK380.74690950
73TNK20.74195988
74DYRK1B0.73285148
75KIT0.72470537
76PDPK10.71740424
77MAP3K120.71230020
78PTK2B0.70067564
79ERBB20.68560306
80TLK10.66983754
81JAK30.66565779
82AKT30.65714191
83CCNB10.63705202
84TRIB30.63446041
85TGFBR20.62479435
86PRKCI0.59524839
87RIPK10.58631161
88LYN0.58094992
89SYK0.57256682
90STK30.55973276
91NEK20.54948923
92MAPKAPK50.53791908
93PRPF4B0.53594081
94TBK10.53511061
95NEK90.52871836
96BRD40.52739137
97RPS6KA50.52317681
98DDR20.52032340
99EPHA20.51769623
100PBK0.50002388
101MARK30.49384757
102ZAP700.49235465
103TTK0.49142525
104DYRK30.47423803
105TAOK10.47115011
106CHEK20.46789409
107PRKD30.46671898
108MAP4K10.46332310
109CAMKK10.46314247
110TYK20.42813813
111CDK120.41938766
112PRKCD0.41412970
113PRKAA20.40685738
114RPS6KB10.40461015
115JAK10.38888585
116PLK20.38886378
117ROCK20.38741687
118PRKCQ0.37556401
119AURKA0.37429281
120PRKCE0.37336480
121PDK10.36525885
122SGK10.36451843
123PIM10.36273908
124SGK30.36207603
125PNCK0.35266588
126HIPK20.35238826
127HCK0.34588617
128ATM0.33962657
129LATS10.33471988
130BCR0.32862855
131BRAF0.32158658
132RPS6KA60.32134275
133ROCK10.32119455
134MAPK70.31880651
135PRKG10.31337170
136FER0.31171218
137RPS6KA20.29140302
138ICK0.29068293
139CAMK2G0.28173022
140LCK0.27805988
141PTK60.27469123
142MAP2K20.27319384
143KSR20.26137723
144FYN0.25186146
145BRSK20.24954119
146FGFR30.23988521
147MET0.23745915
148CDC42BPA0.22470081
149MAP3K40.19619997
150RET0.19241258
151ABL10.18679751
152MAP2K40.18374503
153RPS6KB20.16576301
154PRKCZ0.16458305
155CAMK1G0.16076285
156MATK0.15572636
157PAK10.15029991
158MAP3K110.14823965
159SRC0.14816188
160AKT20.14656076
161MAP3K80.14410916
162PRKCA0.13310696
163PAK40.12301625
164PRKACA0.11579261
165MAP3K10.11363226
166ADRBK10.11328637
167DYRK1A0.11230164

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine metabolism_Homo sapiens_hsa003604.99994761
2Chemical carcinogenesis_Homo sapiens_hsa052044.27877592
3Histidine metabolism_Homo sapiens_hsa003404.23107339
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.96559849
5Tyrosine metabolism_Homo sapiens_hsa003503.89667053
6Fanconi anemia pathway_Homo sapiens_hsa034603.02287654
7beta-Alanine metabolism_Homo sapiens_hsa004102.74784083
8Graft-versus-host disease_Homo sapiens_hsa053322.43159523
9Glutathione metabolism_Homo sapiens_hsa004802.40699889
10Basal transcription factors_Homo sapiens_hsa030222.40141916
11Allograft rejection_Homo sapiens_hsa053302.31502011
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.29842003
13Homologous recombination_Homo sapiens_hsa034402.23782113
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.04776945
15Autoimmune thyroid disease_Homo sapiens_hsa053202.04497473
16Intestinal immune network for IgA production_Homo sapiens_hsa046722.00423999
17NF-kappa B signaling pathway_Homo sapiens_hsa040642.00277315
18Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.96868342
19Arachidonic acid metabolism_Homo sapiens_hsa005901.78868945
20Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.78374347
21Caffeine metabolism_Homo sapiens_hsa002321.76476083
22Measles_Homo sapiens_hsa051621.71322982
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.63188812
24Hematopoietic cell lineage_Homo sapiens_hsa046401.61608216
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.56210678
26Rheumatoid arthritis_Homo sapiens_hsa053231.55111894
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.52644921
28Primary immunodeficiency_Homo sapiens_hsa053401.51858338
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.51039924
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.49311835
31Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.45977098
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.44609886
33Tight junction_Homo sapiens_hsa045301.42719782
34Linoleic acid metabolism_Homo sapiens_hsa005911.41495397
35Non-homologous end-joining_Homo sapiens_hsa034501.40259404
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.38884414
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.36222486
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.35128481
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.33453787
40ABC transporters_Homo sapiens_hsa020101.30188650
41Herpes simplex infection_Homo sapiens_hsa051681.26108916
42Asthma_Homo sapiens_hsa053101.24982881
43Purine metabolism_Homo sapiens_hsa002301.24241575
44Fatty acid degradation_Homo sapiens_hsa000711.22779508
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.21459004
46Sphingolipid metabolism_Homo sapiens_hsa006001.20924829
47Leishmaniasis_Homo sapiens_hsa051401.20695546
48Base excision repair_Homo sapiens_hsa034101.18755932
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.18315831
50Malaria_Homo sapiens_hsa051441.17948663
51Ether lipid metabolism_Homo sapiens_hsa005651.16661002
52Vitamin B6 metabolism_Homo sapiens_hsa007501.15217284
53Jak-STAT signaling pathway_Homo sapiens_hsa046301.15145712
54Type I diabetes mellitus_Homo sapiens_hsa049401.14447820
55Pyrimidine metabolism_Homo sapiens_hsa002401.14006748
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.13794500
57Influenza A_Homo sapiens_hsa051641.13428356
58Glycosaminoglycan degradation_Homo sapiens_hsa005311.13009202
59Phototransduction_Homo sapiens_hsa047441.12429534
60Legionellosis_Homo sapiens_hsa051341.10399694
61Nicotine addiction_Homo sapiens_hsa050331.10220366
62African trypanosomiasis_Homo sapiens_hsa051431.07970478
63Carbohydrate digestion and absorption_Homo sapiens_hsa049731.06098009
64DNA replication_Homo sapiens_hsa030301.05729463
65Nucleotide excision repair_Homo sapiens_hsa034201.04320898
66Other glycan degradation_Homo sapiens_hsa005111.03277734
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.99677416
68RNA degradation_Homo sapiens_hsa030180.98666641
69Fatty acid biosynthesis_Homo sapiens_hsa000610.97501795
70TNF signaling pathway_Homo sapiens_hsa046680.96817263
71Salivary secretion_Homo sapiens_hsa049700.95946373
72Leukocyte transendothelial migration_Homo sapiens_hsa046700.95939589
73Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.93486666
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.93303499
75Osteoclast differentiation_Homo sapiens_hsa043800.85362168
76Antigen processing and presentation_Homo sapiens_hsa046120.83264096
77Hedgehog signaling pathway_Homo sapiens_hsa043400.79978586
78Choline metabolism in cancer_Homo sapiens_hsa052310.79707393
79Phagosome_Homo sapiens_hsa041450.79274591
80Taste transduction_Homo sapiens_hsa047420.79188468
81Circadian rhythm_Homo sapiens_hsa047100.79011060
82Peroxisome_Homo sapiens_hsa041460.78817195
83Adherens junction_Homo sapiens_hsa045200.78211853
84Mismatch repair_Homo sapiens_hsa034300.77488923
85Hepatitis C_Homo sapiens_hsa051600.76290072
86Ovarian steroidogenesis_Homo sapiens_hsa049130.74774368
87Tuberculosis_Homo sapiens_hsa051520.74298371
88Starch and sucrose metabolism_Homo sapiens_hsa005000.71752849
89Pertussis_Homo sapiens_hsa051330.71145051
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70936976
91Staphylococcus aureus infection_Homo sapiens_hsa051500.69833530
92Toxoplasmosis_Homo sapiens_hsa051450.66928946
93Protein export_Homo sapiens_hsa030600.64296840
94Mineral absorption_Homo sapiens_hsa049780.63992270
95RNA polymerase_Homo sapiens_hsa030200.62134070
96p53 signaling pathway_Homo sapiens_hsa041150.61069738
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58011641
98Collecting duct acid secretion_Homo sapiens_hsa049660.57239184
99Calcium signaling pathway_Homo sapiens_hsa040200.56546128
100Cell cycle_Homo sapiens_hsa041100.56532642
101Olfactory transduction_Homo sapiens_hsa047400.54799148
102Apoptosis_Homo sapiens_hsa042100.54743691
103Salmonella infection_Homo sapiens_hsa051320.54367494
104Vitamin digestion and absorption_Homo sapiens_hsa049770.53953389
105Huntingtons disease_Homo sapiens_hsa050160.52046428
106Endocytosis_Homo sapiens_hsa041440.50791232
107Drug metabolism - other enzymes_Homo sapiens_hsa009830.50668833
108Epstein-Barr virus infection_Homo sapiens_hsa051690.49766053
109PPAR signaling pathway_Homo sapiens_hsa033200.49735590
110Hepatitis B_Homo sapiens_hsa051610.49643567
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49640425
112Amoebiasis_Homo sapiens_hsa051460.48136066
113Morphine addiction_Homo sapiens_hsa050320.47415322
114B cell receptor signaling pathway_Homo sapiens_hsa046620.46923307
115T cell receptor signaling pathway_Homo sapiens_hsa046600.46186719
116cAMP signaling pathway_Homo sapiens_hsa040240.45179639
117Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45175714
118Primary bile acid biosynthesis_Homo sapiens_hsa001200.45011568
119Serotonergic synapse_Homo sapiens_hsa047260.44983067
120Basal cell carcinoma_Homo sapiens_hsa052170.44762605
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43364624
122Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42854744
123Chemokine signaling pathway_Homo sapiens_hsa040620.42841194
124Inositol phosphate metabolism_Homo sapiens_hsa005620.41315136
125Systemic lupus erythematosus_Homo sapiens_hsa053220.40739211
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40729998
127Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39525717
128Steroid hormone biosynthesis_Homo sapiens_hsa001400.37891310
129Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.37791326
130Sphingolipid signaling pathway_Homo sapiens_hsa040710.37697112
131HTLV-I infection_Homo sapiens_hsa051660.37656984
132Retinol metabolism_Homo sapiens_hsa008300.35655518
133Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35175492
134Cocaine addiction_Homo sapiens_hsa050300.33188431
135Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.32932113
136Viral myocarditis_Homo sapiens_hsa054160.32202368
137Glycerophospholipid metabolism_Homo sapiens_hsa005640.31036893
138Notch signaling pathway_Homo sapiens_hsa043300.30513433
139Prostate cancer_Homo sapiens_hsa052150.29953500
140Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29377718
141Complement and coagulation cascades_Homo sapiens_hsa046100.28862523
142Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28769915
143Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27524879
144Insulin resistance_Homo sapiens_hsa049310.26903691
145Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.21484437
146Hippo signaling pathway_Homo sapiens_hsa043900.19725634
147Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.19489701
148Arginine and proline metabolism_Homo sapiens_hsa003300.18834839
149Lysosome_Homo sapiens_hsa041420.18825529
150Pancreatic secretion_Homo sapiens_hsa049720.16935978
151Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.16252836
152Axon guidance_Homo sapiens_hsa043600.15732657
153Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.14967967
154Glycerolipid metabolism_Homo sapiens_hsa005610.14686555
155Adipocytokine signaling pathway_Homo sapiens_hsa049200.13595745
156Melanogenesis_Homo sapiens_hsa049160.12228256
157Pancreatic cancer_Homo sapiens_hsa052120.11766910
158Gastric acid secretion_Homo sapiens_hsa049710.11615481
159Metabolic pathways_Homo sapiens_hsa011000.10948885

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