CFAP46

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)8.73073126
2cilium movement (GO:0003341)8.47114357
3epithelial cilium movement (GO:0003351)7.62044095
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.29419992
5motile cilium assembly (GO:0044458)6.30983793
6primary alcohol catabolic process (GO:0034310)5.89827794
7axoneme assembly (GO:0035082)5.75572854
8sperm motility (GO:0030317)5.63451581
9vitamin transmembrane transport (GO:0035461)5.34244515
10fusion of sperm to egg plasma membrane (GO:0007342)5.27822143
11acrosome reaction (GO:0007340)5.21817621
12multicellular organism reproduction (GO:0032504)5.18268780
13ventricular system development (GO:0021591)5.14806680
14ethanol metabolic process (GO:0006067)5.02893654
15centriole assembly (GO:0098534)4.80428068
16acrosome assembly (GO:0001675)4.74906997
17lung epithelium development (GO:0060428)4.74068881
18regulation of cilium movement (GO:0003352)4.70375930
19piRNA metabolic process (GO:0034587)4.69279109
20diterpenoid biosynthetic process (GO:0016102)4.57324402
21cell projection assembly (GO:0030031)4.41649223
22axon ensheathment in central nervous system (GO:0032291)4.30176380
23central nervous system myelination (GO:0022010)4.30176380
24response to xenobiotic stimulus (GO:0009410)4.28629545
25plasma membrane fusion (GO:0045026)4.14471628
26pyrimidine-containing compound transmembrane transport (GO:0072531)4.12103525
27sperm-egg recognition (GO:0035036)4.06245477
28male meiosis (GO:0007140)4.06010494
29one-carbon compound transport (GO:0019755)4.03614762
30establishment of apical/basal cell polarity (GO:0035089)3.95115796
31reproduction (GO:0000003)3.95021556
32glomerular epithelial cell development (GO:0072310)3.94475544
33cytoplasmic microtubule organization (GO:0031122)3.89833309
34tolerance induction (GO:0002507)3.88727191
35spermatid development (GO:0007286)3.87166120
36regulation of interleukin-5 production (GO:0032674)3.86634808
37neuron cell-cell adhesion (GO:0007158)3.84746101
38negative regulation of T cell differentiation in thymus (GO:0033085)3.83784168
39lateral ventricle development (GO:0021670)3.79182639
40single fertilization (GO:0007338)3.74529059
41ethanol oxidation (GO:0006069)3.73900233
42negative regulation of immunoglobulin mediated immune response (GO:0002890)3.73472422
43negative regulation of B cell mediated immunity (GO:0002713)3.73472422
44GTP biosynthetic process (GO:0006183)3.69679765
45microtubule depolymerization (GO:0007019)3.68996708
46presynaptic membrane assembly (GO:0097105)3.68705109
47protein localization to cilium (GO:0061512)3.68609719
48left/right axis specification (GO:0070986)3.67451674
49intraciliary transport (GO:0042073)3.66799134
50left/right pattern formation (GO:0060972)3.66063271
51microtubule polymerization or depolymerization (GO:0031109)3.65120539
52sperm capacitation (GO:0048240)3.55143088
53establishment of monopolar cell polarity (GO:0061162)3.54439972
54establishment or maintenance of monopolar cell polarity (GO:0061339)3.54439972
55cell-cell recognition (GO:0009988)3.53501048
56determination of left/right symmetry (GO:0007368)3.53188856
57negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.52124188
58cell wall macromolecule catabolic process (GO:0016998)3.49007511
59cell wall macromolecule metabolic process (GO:0044036)3.49007511
60cilium organization (GO:0044782)3.45708992
61negative regulation of inclusion body assembly (GO:0090084)3.43842017
62negative regulation of humoral immune response (GO:0002921)3.42875112
63regulation of interleukin-13 production (GO:0032656)3.41824918
64determination of bilateral symmetry (GO:0009855)3.41080382
65nucleoside diphosphate phosphorylation (GO:0006165)3.40781456
66presynaptic membrane organization (GO:0097090)3.40199154
67cilium assembly (GO:0042384)3.39559501
68calcium ion-dependent exocytosis (GO:0017156)3.39178941
69positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.36777012
70establishment of tissue polarity (GO:0007164)3.36576499
71establishment of planar polarity (GO:0001736)3.36576499
72regulation of germinal center formation (GO:0002634)3.36492457
73terpenoid biosynthetic process (GO:0016114)3.36141660
74DNA methylation involved in gamete generation (GO:0043046)3.36128482
75specification of symmetry (GO:0009799)3.33301802
76cilium morphogenesis (GO:0060271)3.31736970
77binding of sperm to zona pellucida (GO:0007339)3.31713513
78synaptonemal complex organization (GO:0070193)3.30535811
79retinoic acid metabolic process (GO:0042573)3.26932032
80smoothened signaling pathway (GO:0007224)3.22387972
81vocalization behavior (GO:0071625)3.22172681
82ionotropic glutamate receptor signaling pathway (GO:0035235)3.20414891
83positive regulation of smoothened signaling pathway (GO:0045880)3.20124130
84lateral sprouting from an epithelium (GO:0060601)3.19179154
85spermatid nucleus differentiation (GO:0007289)3.17568654
86retina layer formation (GO:0010842)3.16917962
87neuronal action potential propagation (GO:0019227)3.15623265
88fertilization (GO:0009566)3.14402547
89regulation of microtubule-based movement (GO:0060632)3.10541241
90positive regulation of tolerance induction (GO:0002645)3.06428532
91retinal rod cell development (GO:0046548)3.05380133
92microtubule-based movement (GO:0007018)3.03208477
93protein localization to synapse (GO:0035418)3.01940057
94microtubule-based process (GO:0007017)3.01485047
95cellular component assembly involved in morphogenesis (GO:0010927)3.00243868
96UTP biosynthetic process (GO:0006228)2.98625301
97microtubule severing (GO:0051013)2.97814074
98limb bud formation (GO:0060174)2.97000735
99startle response (GO:0001964)2.96696421
100negative regulation of synaptic transmission, GABAergic (GO:0032229)2.94016011
101calcium ion import (GO:0070509)2.93980484
102glutamate receptor signaling pathway (GO:0007215)2.91180376
103apical protein localization (GO:0045176)2.90964060
104centriole replication (GO:0007099)2.90945404
105nonmotile primary cilium assembly (GO:0035058)2.89948870
106regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.89760040
107righting reflex (GO:0060013)2.89165687
108gamma-aminobutyric acid signaling pathway (GO:0007214)2.88709652
109regulation of microtubule depolymerization (GO:0031114)2.86498656
110glutathione derivative biosynthetic process (GO:1901687)2.85569003
111glutathione derivative metabolic process (GO:1901685)2.85569003
112microtubule bundle formation (GO:0001578)2.85361353
113postsynaptic membrane organization (GO:0001941)2.84987924
114organelle assembly (GO:0070925)2.84447104
115neuron recognition (GO:0008038)2.84289203
116transmission of nerve impulse (GO:0019226)2.82289411
117male meiosis I (GO:0007141)2.81012352
118exogenous drug catabolic process (GO:0042738)2.79396419
119heart looping (GO:0001947)2.78966605
120cell recognition (GO:0008037)2.78190556
121positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.77498947
122synaptonemal complex assembly (GO:0007130)2.76907816
123regulation of inclusion body assembly (GO:0090083)2.76421233
124protein polyglutamylation (GO:0018095)2.75620292
125negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.75604211
126skeletal muscle contraction (GO:0003009)2.75253349
127positive regulation of protein kinase C signaling (GO:0090037)2.72461336
128gamma-aminobutyric acid transport (GO:0015812)2.72260306
129long-chain fatty acid biosynthetic process (GO:0042759)2.70319111
130positive regulation of action potential (GO:0045760)2.66597950
131regulation of protein kinase A signaling (GO:0010738)2.65812146
132negative regulation of neurotransmitter transport (GO:0051589)2.65553330
133carnitine metabolic process (GO:0009437)2.63250566
134response to epinephrine (GO:0071871)2.61992070
135spinal cord motor neuron differentiation (GO:0021522)2.61812520
136keratinocyte development (GO:0003334)2.61518900
137embryonic heart tube morphogenesis (GO:0003143)2.58496852
138positive regulation of meiosis (GO:0045836)2.58425109
139L-amino acid import (GO:0043092)2.56188510
140photoreceptor cell maintenance (GO:0045494)2.55112438
141eye photoreceptor cell differentiation (GO:0001754)2.55057717
142photoreceptor cell differentiation (GO:0046530)2.55057717
143phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.53849062
144asymmetric protein localization (GO:0008105)2.53844090
145neuron-neuron synaptic transmission (GO:0007270)2.53574613
146aldehyde catabolic process (GO:0046185)2.53126493
147regulation of autophagic vacuole assembly (GO:2000785)2.53010323
148regulation of inositol phosphate biosynthetic process (GO:0010919)2.52302034
149synaptic transmission, glutamatergic (GO:0035249)2.52071836
150regulation of glutamate receptor signaling pathway (GO:1900449)2.52040233
151UTP metabolic process (GO:0046051)2.52017863
152G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.51025222
153primary alcohol metabolic process (GO:0034308)2.50518624
154regulation of smoothened signaling pathway (GO:0008589)2.50309691
155positive regulation of meiotic cell cycle (GO:0051446)2.49028797
156import into cell (GO:0098657)2.49004076
157spermatogenesis (GO:0007283)2.48030019
158membrane depolarization during action potential (GO:0086010)2.46670629
159O-glycan processing (GO:0016266)2.45548169
160retinal cone cell development (GO:0046549)2.44404401
161embryonic camera-type eye development (GO:0031076)2.41059514
162hydrogen peroxide biosynthetic process (GO:0050665)2.40303336
163negative regulation of microtubule depolymerization (GO:0007026)2.36373977
164regulation of collateral sprouting (GO:0048670)2.35448996
165retinol metabolic process (GO:0042572)2.33800677
166CDP-diacylglycerol biosynthetic process (GO:0016024)2.30596195
167mitochondrion degradation (GO:0000422)2.29800465
168excretion (GO:0007588)2.28444549
169phosphatidylcholine biosynthetic process (GO:0006656)2.20463324
170dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.20349443
171regulation of cilium assembly (GO:1902017)2.19775368
172cilium or flagellum-dependent cell motility (GO:0001539)11.2196109

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.77152046
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.41695668
3GBX2_23144817_ChIP-Seq_PC3_Human3.21078043
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.66719424
5FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.64506959
6TAF15_26573619_Chip-Seq_HEK293_Human2.34705667
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.21722097
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.21396133
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.20191394
10CBX2_27304074_Chip-Seq_ESCs_Mouse2.18162816
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.12493559
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.10582022
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.06864125
14VDR_22108803_ChIP-Seq_LS180_Human2.04713863
15CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97121339
16BMI1_23680149_ChIP-Seq_NPCS_Mouse1.94829376
17EED_16625203_ChIP-ChIP_MESCs_Mouse1.93781457
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.93024978
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.92603773
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.92568703
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.92547125
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.85979420
23EZH2_27294783_Chip-Seq_ESCs_Mouse1.81904982
24ESR1_20079471_ChIP-ChIP_T-47D_Human1.81739900
25REST_21632747_ChIP-Seq_MESCs_Mouse1.81691656
26EZH2_18974828_ChIP-Seq_MESCs_Mouse1.80630113
27RNF2_18974828_ChIP-Seq_MESCs_Mouse1.80630113
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80558904
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.79047342
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.78411366
31SUZ12_27294783_Chip-Seq_ESCs_Mouse1.78236478
32JARID2_20075857_ChIP-Seq_MESCs_Mouse1.78171373
33RNF2_27304074_Chip-Seq_NSC_Mouse1.74911110
34AHR_22903824_ChIP-Seq_MCF-7_Human1.74091973
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.73263437
36BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.72711409
37MTF2_20144788_ChIP-Seq_MESCs_Mouse1.72038299
38TRIM28_21343339_ChIP-Seq_HEK293_Human1.71186997
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.70882794
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.67880471
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.67285316
42P300_19829295_ChIP-Seq_ESCs_Human1.61465885
43SMAD4_21799915_ChIP-Seq_A2780_Human1.60537117
44SMC4_20622854_ChIP-Seq_HELA_Human1.60323724
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58291791
46PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.56647679
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.55061274
48FOXM1_26456572_ChIP-Seq_MCF-7_Human1.54982824
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.53023918
50AR_21572438_ChIP-Seq_LNCaP_Human1.52427302
51TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.50958181
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49262765
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46999525
54ER_23166858_ChIP-Seq_MCF-7_Human1.46620202
55ESR2_21235772_ChIP-Seq_MCF-7_Human1.46559384
56FUS_26573619_Chip-Seq_HEK293_Human1.46268409
57DROSHA_22980978_ChIP-Seq_HELA_Human1.45638899
58RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45211228
59STAT1_20625510_ChIP-Seq_HELA_Human1.44124991
60ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.43540317
61NANOG_18555785_Chip-Seq_ESCs_Mouse1.42934667
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42416003
63PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41566145
64TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.40707555
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.37937943
66EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.37203614
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36884975
68RUNX1_27514584_Chip-Seq_MCF-7_Human1.36635799
69IKZF1_21737484_ChIP-ChIP_HCT116_Human1.35816844
70CTNNB1_20460455_ChIP-Seq_HCT116_Human1.35147736
71FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.35096502
72NFE2_27457419_Chip-Seq_LIVER_Mouse1.35090923
73ZNF217_24962896_ChIP-Seq_MCF-7_Human1.34542715
74NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.33245372
75UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32599928
76ZNF274_21170338_ChIP-Seq_K562_Hela1.31981728
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.31890420
78TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31890420
79TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31723168
80TP53_18474530_ChIP-ChIP_U2OS_Human1.31409147
81TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31301917
82IGF1R_20145208_ChIP-Seq_DFB_Human1.31088812
83TP63_23658742_ChIP-Seq_EP156T_Human1.30134558
84MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.30126917
85CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.30010024
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.29915671
87RAD21_21589869_ChIP-Seq_MESCs_Mouse1.27802453
88CTCF_27219007_Chip-Seq_Bcells_Human1.26545788
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25816747
90P53_22387025_ChIP-Seq_ESCs_Mouse1.24723775
91ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24288995
92TP63_22573176_ChIP-Seq_HFKS_Human1.23878772
93STAT3_23295773_ChIP-Seq_U87_Human1.23870286
94ETV1_20927104_ChIP-Seq_GIST48_Human1.23470100
95E2F1_18555785_Chip-Seq_ESCs_Mouse1.23331221
96SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.23298747
97KLF5_25053715_ChIP-Seq_YYC3_Human1.23237907
98CMYC_18555785_Chip-Seq_ESCs_Mouse1.22110359
99TDRD3_21172665_ChIP-Seq_MCF-7_Human1.21633640
100TCF4_23295773_ChIP-Seq_U87_Human1.21203884
101EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.20596407
102SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.20369680
103EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.19935515
104SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19489672
105NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19300697
106OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19186560
107SUZ12_18555785_Chip-Seq_ESCs_Mouse1.19036291
108PHF8_20622853_ChIP-Seq_HELA_Human1.18962239
109EZH2_27294783_Chip-Seq_NPCs_Mouse1.18636876
110PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.17756017
111P300_18555785_Chip-Seq_ESCs_Mouse1.17002541
112ESR1_21235772_ChIP-Seq_MCF-7_Human1.16285870
113AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.15996344
114STAT3_18555785_Chip-Seq_ESCs_Mouse1.15663883
115CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.15419159
116WDR5_24793694_ChIP-Seq_LNCAP_Human1.14755533
117CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14731971
118SOX2_27498859_Chip-Seq_STOMACH_Mouse1.14584756
119PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.14249411
120MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14015206
121MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13849135
122SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13241077
123FOXA1_25552417_ChIP-Seq_VCAP_Human1.12939680
124HNFA_21074721_ChIP-Seq_CACO-2_Human1.12519493
125TAL1_26923725_Chip-Seq_HPCs_Mouse1.12225307
126KDM2B_26808549_Chip-Seq_REH_Human1.12148402
127REST_18959480_ChIP-ChIP_MESCs_Mouse1.11684175
128SOX9_24532713_ChIP-Seq_HFSC_Mouse1.11489562
129SMAD3_21741376_ChIP-Seq_HESCs_Human1.11275337
130AR_25329375_ChIP-Seq_VCAP_Human1.11076936
131OCT4_18555785_Chip-Seq_ESCs_Mouse1.10729470
132ARNT_22903824_ChIP-Seq_MCF-7_Human1.10171974
133MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.09692781
134CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.09651267
135SMRT_27268052_Chip-Seq_Bcells_Human1.09245828
136RUNX2_22187159_ChIP-Seq_PCA_Human1.09238571
137SOX2_18555785_Chip-Seq_ESCs_Mouse1.08874869
138GATA1_26923725_Chip-Seq_HPCs_Mouse1.08481402
139KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07987485
140TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07571011
141BCAT_22108803_ChIP-Seq_LS180_Human1.06314094
142RUNX1_27457419_Chip-Seq_LIVER_Mouse1.05837837
143ELF1_20517297_ChIP-Seq_JURKAT_Human1.05027341
144KLF4_18555785_Chip-Seq_ESCs_Mouse1.04259012
145PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04053693
146TBL1_22424771_ChIP-Seq_293T_Human1.03274375
147NFYA_21822215_ChIP-Seq_K562_Human1.02238893
148YY1_22570637_ChIP-Seq_MALME-3M_Human1.01769029
149SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01707723
150SMAD4_21741376_ChIP-Seq_HESCs_Human1.01070063
151AR_19668381_ChIP-Seq_PC3_Human0.99361307
152NFYB_21822215_ChIP-Seq_K562_Human0.96954540
153CBP_20019798_ChIP-Seq_JUKART_Human0.96537745
154IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96537745
155CBX2_22325352_ChIP-Seq_293T-Rex_Human0.95920995
156SMAD4_21741376_ChIP-Seq_EPCs_Human0.93629343
157P63_26484246_Chip-Seq_KERATINOCYTES_Human0.92707126
158RBPJ_21746931_ChIP-Seq_IB4_Human0.92532004
159PHF8_20622854_ChIP-Seq_HELA_Human0.91830919
160EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.89975372
161CTCF_20526341_ChIP-Seq_ESCs_Human0.88411785
162P68_20966046_ChIP-Seq_HELA_Human0.87329192
163GATA6_21074721_ChIP-Seq_CACO-2_Human0.87015092
164CBP_21632823_ChIP-Seq_H3396_Human0.86105768
165FLI1_21867929_ChIP-Seq_CD8_Mouse0.86061183
166STAT1_17558387_ChIP-Seq_HELA_Human0.84986746
167E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.84733279
168HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.84623076

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.16833795
2MP0008875_abnormal_xenobiotic_pharmacok4.86911356
3MP0002132_abnormal_respiratory_system4.18380141
4MP0008789_abnormal_olfactory_epithelium4.10252568
5MP0003880_abnormal_central_pattern3.64403907
6MP0009046_muscle_twitch3.22927251
7MP0004043_abnormal_pH_regulation3.09109240
8MP0002277_abnormal_respiratory_mucosa2.94446537
9MP0003136_yellow_coat_color2.88650310
10MP0002102_abnormal_ear_morphology2.64423529
11MP0004859_abnormal_synaptic_plasticity2.58775469
12MP0003635_abnormal_synaptic_transmissio2.50445710
13MP0001486_abnormal_startle_reflex2.50302835
14MP0002282_abnormal_trachea_morphology2.47298802
15MP0009745_abnormal_behavioral_response2.37803330
16MP0001984_abnormal_olfaction2.37318694
17MP0005423_abnormal_somatic_nervous2.31376079
18MP0003698_abnormal_male_reproductive2.29125399
19MP0000383_abnormal_hair_follicle2.26576383
20MP0002064_seizures2.24278031
21MP0010030_abnormal_orbit_morphology2.23953079
22MP0005646_abnormal_pituitary_gland2.17871170
23MP0004270_analgesia2.14902613
24MP0005623_abnormal_meninges_morphology2.14857729
25MP0002272_abnormal_nervous_system2.14475468
26MP0002572_abnormal_emotion/affect_behav2.13772360
27MP0001440_abnormal_grooming_behavior2.10951340
28MP0003878_abnormal_ear_physiology2.08509299
29MP0005377_hearing/vestibular/ear_phenot2.08509299
30MP0005645_abnormal_hypothalamus_physiol2.01577508
31MP0001968_abnormal_touch/_nociception1.99744439
32MP0002063_abnormal_learning/memory/cond1.90121255
33MP0004742_abnormal_vestibular_system1.87803896
34MP0008877_abnormal_DNA_methylation1.87252567
35MP0005248_abnormal_Harderian_gland1.84845950
36MP0002734_abnormal_mechanical_nocicepti1.76385248
37MP0001346_abnormal_lacrimal_gland1.75700389
38MP0010678_abnormal_skin_adnexa1.74832333
39MP0001501_abnormal_sleep_pattern1.73595375
40MP0001188_hyperpigmentation1.73320184
41MP0002557_abnormal_social/conspecific_i1.70346567
42MP0000778_abnormal_nervous_system1.68702863
43MP0002653_abnormal_ependyma_morphology1.67032763
44MP0001929_abnormal_gametogenesis1.66751592
45MP0002067_abnormal_sensory_capabilities1.65755693
46MP0005551_abnormal_eye_electrophysiolog1.60069143
47MP0000678_abnormal_parathyroid_gland1.55740364
48MP0004142_abnormal_muscle_tone1.54993666
49MP0003787_abnormal_imprinting1.54661381
50MP0006276_abnormal_autonomic_nervous1.52856630
51MP0002735_abnormal_chemical_nociception1.52096310
52MP0002168_other_aberrant_phenotype1.47966623
53MP0000566_synostosis1.44335398
54MP0006292_abnormal_olfactory_placode1.43336965
55MP0001905_abnormal_dopamine_level1.42423708
56MP0002736_abnormal_nociception_after1.41536014
57MP0001485_abnormal_pinna_reflex1.38408359
58MP0001529_abnormal_vocalization1.36069757
59MP0004019_abnormal_vitamin_homeostasis1.35826083
60MP0009780_abnormal_chondrocyte_physiolo1.34910174
61MP0000026_abnormal_inner_ear1.33464643
62MP0000631_abnormal_neuroendocrine_gland1.33278202
63MP0001970_abnormal_pain_threshold1.32694716
64MP0001963_abnormal_hearing_physiology1.32362036
65MP0002249_abnormal_larynx_morphology1.32228711
66MP0006072_abnormal_retinal_apoptosis1.31675417
67MP0002184_abnormal_innervation1.30761466
68MP0002733_abnormal_thermal_nociception1.28740207
69MP0003938_abnormal_ear_development1.26737624
70MP0008995_early_reproductive_senescence1.25542044
71MP0000920_abnormal_myelination1.25461706
72MP0003283_abnormal_digestive_organ1.23749878
73MP0005409_darkened_coat_color1.22868670
74MP0001765_abnormal_ion_homeostasis1.18964828
75MP0002882_abnormal_neuron_morphology1.18227118
76MP0001502_abnormal_circadian_rhythm1.18088415
77MP0002161_abnormal_fertility/fecundity1.17490811
78MP0002638_abnormal_pupillary_reflex1.17333477
79MP0003656_abnormal_erythrocyte_physiolo1.16819769
80MP0003890_abnormal_embryonic-extraembry1.16417786
81MP0001293_anophthalmia1.15021004
82MP0002210_abnormal_sex_determination1.13785410
83MP0002752_abnormal_somatic_nervous1.09829695
84MP0001849_ear_inflammation1.09255393
85MP0003690_abnormal_glial_cell1.08403420
86MP0002234_abnormal_pharynx_morphology1.08213571
87MP0000955_abnormal_spinal_cord1.06840483
88MP0002066_abnormal_motor_capabilities/c1.06347838
89MP0004885_abnormal_endolymph1.05997003
90MP0003879_abnormal_hair_cell1.05939723
91MP0003634_abnormal_glial_cell1.04429472
92MP0002229_neurodegeneration1.03605363
93MP0002909_abnormal_adrenal_gland1.03560891
94MP0003122_maternal_imprinting1.03454117
95MP0008569_lethality_at_weaning1.01496001
96MP0005253_abnormal_eye_physiology0.99581047
97MP0004924_abnormal_behavior0.99492990
98MP0005386_behavior/neurological_phenoty0.99492990
99MP0004145_abnormal_muscle_electrophysio0.99293751
100MP0004133_heterotaxia0.99015524
101MP0002152_abnormal_brain_morphology0.98837263
102MP0004381_abnormal_hair_follicle0.98022980
103MP0002160_abnormal_reproductive_system0.92273619
104MP0000751_myopathy0.92067190
105MP0005083_abnormal_biliary_tract0.91261971
106MP0003950_abnormal_plasma_membrane0.90976054
107MP0002822_catalepsy0.90650463
108MP0003329_amyloid_beta_deposits0.88909993
109MP0005171_absent_coat_pigmentation0.88048780
110MP0003937_abnormal_limbs/digits/tail_de0.86233179
111MP0001145_abnormal_male_reproductive0.85805638
112MP0010386_abnormal_urinary_bladder0.85435918
113MP0003633_abnormal_nervous_system0.85261361
114MP0005395_other_phenotype0.85141478
115MP0001986_abnormal_taste_sensitivity0.85130326
116MP0002332_abnormal_exercise_endurance0.84417212
117MP0002876_abnormal_thyroid_physiology0.84330366
118MP0005499_abnormal_olfactory_system0.81667297
119MP0005394_taste/olfaction_phenotype0.81667297
120MP0001299_abnormal_eye_distance/0.80224308
121MP0009250_abnormal_appendicular_skeleto0.79945285
122MP0000049_abnormal_middle_ear0.78003766
123MP0000653_abnormal_sex_gland0.77787254
124MP0005636_abnormal_mineral_homeostasis0.77714496
125MP0000462_abnormal_digestive_system0.77471289
126MP0001664_abnormal_digestion0.76730952
127MP0002233_abnormal_nose_morphology0.76175391
128MP0004134_abnormal_chest_morphology0.75873512
129MP0005391_vision/eye_phenotype0.75458196
130MP0002116_abnormal_craniofacial_bone0.75279071
131MP0003631_nervous_system_phenotype0.74471062
132MP0005195_abnormal_posterior_eye0.74418458
133MP0005379_endocrine/exocrine_gland_phen0.72791145
134MP0003861_abnormal_nervous_system0.68561222
135MP0000681_abnormal_thyroid_gland0.67846358
136MP0002928_abnormal_bile_duct0.67074891
137MP0003646_muscle_fatigue0.61867817
138MP0008004_abnormal_stomach_pH0.61708422
139MP0001324_abnormal_eye_pigmentation0.60170473
140MP0006036_abnormal_mitochondrial_physio0.58741080
141MP0002092_abnormal_eye_morphology0.56979988
142MP0009703_decreased_birth_body0.56885634
143MP0005165_increased_susceptibility_to0.54616085
144MP0003942_abnormal_urinary_system0.51103881
145MP0002084_abnormal_developmental_patter0.50371011
146MP0005389_reproductive_system_phenotype0.48723989
147MP0001270_distended_abdomen0.48196909
148MP0005408_hypopigmentation0.47849415

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)9.89274967
2Absent/shortened dynein arms (HP:0200106)9.89274967
3Abnormal respiratory motile cilium physiology (HP:0012261)9.21538293
4Abnormal ciliary motility (HP:0012262)9.14317674
5Abnormal respiratory epithelium morphology (HP:0012253)8.08090845
6Abnormal respiratory motile cilium morphology (HP:0005938)8.08090845
7Rhinitis (HP:0012384)6.98893397
8Chronic bronchitis (HP:0004469)4.81481669
9Bronchiectasis (HP:0002110)3.96925582
10Male infertility (HP:0003251)3.71778744
11Nephronophthisis (HP:0000090)3.66530487
12Nasal polyposis (HP:0100582)3.54802772
13Infertility (HP:0000789)3.35016425
14Tubulointerstitial nephritis (HP:0001970)3.22818822
15Abnormality of the renal medulla (HP:0100957)3.15983192
16Focal motor seizures (HP:0011153)3.11661779
17Medial flaring of the eyebrow (HP:0010747)3.09283089
18Molar tooth sign on MRI (HP:0002419)3.00246783
19Abnormality of midbrain morphology (HP:0002418)3.00246783
20Recurrent sinusitis (HP:0011108)2.94392903
21Chronic otitis media (HP:0000389)2.81312062
22Gait imbalance (HP:0002141)2.72956378
23Abnormality of the nasal mucosa (HP:0000433)2.71475796
24Fibular hypoplasia (HP:0003038)2.63431536
25Congenital primary aphakia (HP:0007707)2.59396385
26Pancreatic fibrosis (HP:0100732)2.47220867
27Supernumerary spleens (HP:0009799)2.42812098
28Chronic sinusitis (HP:0011109)2.38832311
29Hyperactive renin-angiotensin system (HP:0000841)2.34908351
30Neurofibrillary tangles (HP:0002185)2.33693537
31Nephrogenic diabetes insipidus (HP:0009806)2.33378894
32Bronchitis (HP:0012387)2.32636582
33Median cleft lip (HP:0000161)2.30322805
34Genital tract atresia (HP:0001827)2.25776104
35Anencephaly (HP:0002323)2.22894337
36Retinal dysplasia (HP:0007973)2.21501049
37Vaginal atresia (HP:0000148)2.17987722
38True hermaphroditism (HP:0010459)2.15864738
39Recurrent otitis media (HP:0000403)2.11971576
40Stage 5 chronic kidney disease (HP:0003774)2.06510634
41Aplasia/Hypoplasia of the lens (HP:0008063)2.05637314
42Congenital hepatic fibrosis (HP:0002612)2.02797887
43Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.7520678
44Tubulointerstitial abnormality (HP:0001969)1.94903598
45Epileptic encephalopathy (HP:0200134)1.94147431
46Focal seizures (HP:0007359)1.92967019
47Decreased central vision (HP:0007663)1.92315808
48Progressive cerebellar ataxia (HP:0002073)1.92290202
49Postaxial foot polydactyly (HP:0001830)1.90887858
50Renal dysplasia (HP:0000110)1.88702291
51Hemiparesis (HP:0001269)1.85582742
52Chronic hepatic failure (HP:0100626)1.84736114
53Recurrent bronchitis (HP:0002837)1.81568426
54Hyperventilation (HP:0002883)1.81139185
55Occipital encephalocele (HP:0002085)1.81036928
56Aplasia/Hypoplasia of the fibula (HP:0006492)1.78655146
57Sclerocornea (HP:0000647)1.78565647
58Septo-optic dysplasia (HP:0100842)1.78391257
59Poor coordination (HP:0002370)1.78151843
60Gaze-evoked nystagmus (HP:0000640)1.77724974
61Atonic seizures (HP:0010819)1.74555222
62Asplenia (HP:0001746)1.73394958
63Postaxial hand polydactyly (HP:0001162)1.72603584
64Aplasia cutis congenita (HP:0001057)1.71402363
65Abnormality of permanent molar morphology (HP:0011071)1.71211063
66Abnormality of the dental root (HP:0006486)1.71211063
67Taurodontia (HP:0000679)1.71211063
68Aplasia/Hypoplasia of the spleen (HP:0010451)1.70534053
69Abnormality of molar morphology (HP:0011070)1.70121468
70Abnormality of molar (HP:0011077)1.70121468
71Atelectasis (HP:0100750)1.69724060
72Short tibia (HP:0005736)1.69596935
73Absent frontal sinuses (HP:0002688)1.68973913
74Oculomotor apraxia (HP:0000657)1.68302481
75Cerebral inclusion bodies (HP:0100314)1.67975884
76Hyperkalemia (HP:0002153)1.67678661
77Degeneration of the lateral corticospinal tracts (HP:0002314)1.67323235
78Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.67323235
79Febrile seizures (HP:0002373)1.66368993
80Preaxial hand polydactyly (HP:0001177)1.65424087
81Aplasia/Hypoplasia of the tibia (HP:0005772)1.64091401
82Widely spaced teeth (HP:0000687)1.62816222
83Aplasia involving bones of the upper limbs (HP:0009823)1.62797399
84Aplasia of the phalanges of the hand (HP:0009802)1.62797399
85Aplasia involving bones of the extremities (HP:0009825)1.62797399
86Bell-shaped thorax (HP:0001591)1.62457705
87Furrowed tongue (HP:0000221)1.62305425
88Abnormality of the dental pulp (HP:0006479)1.61731792
89Limb dystonia (HP:0002451)1.57629870
90Nephropathy (HP:0000112)1.57190722
91Supranuclear gaze palsy (HP:0000605)1.54517887
92Pancreatic cysts (HP:0001737)1.54376749
93Specific learning disability (HP:0001328)1.51079513
94Tubular atrophy (HP:0000092)1.49404213
95Aplasia/Hypoplasia of the tongue (HP:0010295)1.45210694
96Abnormal drinking behavior (HP:0030082)1.45167950
97Polydipsia (HP:0001959)1.45167950
98Absent septum pellucidum (HP:0001331)1.43139953
99Abnormality of the renal cortex (HP:0011035)1.41679489
100Optic nerve hypoplasia (HP:0000609)1.41182747
101Peripheral hypomyelination (HP:0007182)1.41140391
102Broad-based gait (HP:0002136)1.40691746
103Morphological abnormality of the middle ear (HP:0008609)1.40445808
104Male pseudohermaphroditism (HP:0000037)1.40231707
105Cystic liver disease (HP:0006706)1.39857724
106Generalized tonic-clonic seizures (HP:0002069)1.39742683
107Decreased circulating renin level (HP:0003351)1.38326221
108Short nail (HP:0001799)1.38307710
109Muscle fiber splitting (HP:0003555)1.36358739
110Nasolacrimal duct obstruction (HP:0000579)1.36085700
111Renal salt wasting (HP:0000127)1.36061552
112Polyphagia (HP:0002591)1.35507797
113White forelock (HP:0002211)1.34821734
114Parakeratosis (HP:0001036)1.33974148
115Bile duct proliferation (HP:0001408)1.33346272
116Abnormal biliary tract physiology (HP:0012439)1.33346272
117Myokymia (HP:0002411)1.32692710
118Fetal akinesia sequence (HP:0001989)1.26283480
119Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.24324792
120Short thorax (HP:0010306)1.20510658
121Abnormality of dentin (HP:0010299)1.18554442
122Tubulointerstitial fibrosis (HP:0005576)1.17988905
123Hyperaldosteronism (HP:0000859)1.15969743
124Bifid scrotum (HP:0000048)1.14499714
125Cone-rod dystrophy (HP:0000548)1.11229594
126Absent rod-and cone-mediated responses on ERG (HP:0007688)1.11081693
127Retinitis pigmentosa (HP:0000510)1.10753363
128Abnormality of abdominal situs (HP:0011620)1.09314914
129Abdominal situs inversus (HP:0003363)1.09314914
130Down-sloping shoulders (HP:0200021)1.08487914
131Abnormality of chloride homeostasis (HP:0011422)1.07037393
132Narrow forehead (HP:0000341)1.03039803
133Limb-girdle muscle atrophy (HP:0003797)1.01989377
134Broad distal phalanx of finger (HP:0009836)1.01038300
135Aplasia/Hypoplasia involving the sinuses (HP:0009120)0.99483650
136Abnormality of renin-angiotensin system (HP:0000847)0.99296348
137Obstructive sleep apnea (HP:0002870)0.98405756
138Hand muscle atrophy (HP:0009130)0.97497608
139Anosmia (HP:0000458)0.96612819

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK4.41971048
2CASK3.87478222
3EPHA23.64878155
4BLK3.64299117
5MAPK153.19839646
6STK393.09958569
7PDK42.72096404
8PDK32.72096404
9NTRK32.62773532
10TNIK2.40961660
11NTRK22.16201290
12MKNK22.08939235
13WNK42.08040081
14OBSCN1.99322555
15EPHA41.78044795
16OXSR11.73775646
17MAP2K71.70315921
18MAPKAPK31.68383831
19PDK21.66212051
20MARK11.57591132
21CAMK1G1.47924750
22STK241.45373610
23PTK2B1.40763459
24NEK61.40156899
25PKN11.37800813
26IRAK11.35452576
27PAK61.33357948
28WNK11.32989229
29MAP3K41.32868619
30INSRR1.28548693
31EEF2K1.26060187
32TTK1.24884039
33MAP3K21.23786082
34GRK71.21249659
35MUSK1.20772569
36ADRBK21.17722304
37MAPK131.12521855
38FES1.11243487
39MAP4K21.11036172
40EPHA31.09218939
41FGR1.07550288
42CDK31.04753271
43GRK11.02031942
44CAMK2A1.01221393
45CSK0.98670433
46DYRK1A0.98106727
47BMPR1B0.97768839
48MAP3K70.97285880
49MAPKAPK50.97283973
50ICK0.94290351
51SMG10.93475641
52CAMK2B0.92168207
53PRKD30.91839073
54MARK20.88403039
55PAK30.87492816
56BCR0.84231329
57CDK50.84006854
58IRAK20.83939974
59SIK20.82261375
60ERBB30.82215267
61ERBB20.81990430
62PRKCG0.80794995
63PINK10.80697980
64MAP3K30.79727472
65NUAK10.79722654
66TESK10.79635646
67DYRK1B0.78537726
68STK380.77919977
69LRRK20.77848156
70GRK50.77248848
71EPHB10.76529854
72MST1R0.76465529
73PRPF4B0.73940037
74MAP3K130.73901652
75PLK20.73900626
76TNK20.73711867
77TLK10.71825964
78STK100.70873826
79MKNK10.70285662
80PRKCE0.68462204
81LMTK20.67158911
82ROCK20.66784516
83NTRK10.66377230
84CAMKK10.65672395
85STK110.64877280
86MINK10.64376532
87UHMK10.62534602
88CDK190.62298720
89CAMK2D0.60749252
90STK160.60210487
91PRKG10.59773127
92PRKCI0.59137883
93WNK30.56620307
94BMPR20.56036955
95MAP3K120.54057355
96CSNK1G20.53506602
97TRPM70.53325930
98NEK90.53156541
99CCNB10.52576502
100PHKG10.52495223
101PHKG20.52495223
102EPHB20.51705268
103CAMK2G0.51352633
104CAMK10.50823550
105PRKCQ0.50759458
106RIPK40.50354445
107MET0.50289765
108ARAF0.49859869
109SGK4940.49269851
110SGK2230.49269851
111PRKACA0.48371509
112TBK10.48051823
113PRKAA20.45802912
114AURKA0.45524336
115MAP2K40.45327817
116CDC42BPA0.44805660
117BRSK20.44714386
118AKT20.43761658
119AKT30.42097033
120MAPK100.41895808
121MAP2K20.41221731
122YES10.40880812
123MST40.40475163
124FER0.39796909
125SGK10.39472183
126RIPK10.38948884
127TYRO30.38418729
128STK38L0.37853022
129DMPK0.37770623
130NME10.37075705
131PIK3CA0.37047803
132ROCK10.36007390
133CSNK1E0.35979606
134CSNK1G10.35614467
135PAK20.35180588
136RPS6KA20.35010703
137FYN0.34688850
138PLK10.34482188
139ADRBK10.34480346
140DAPK20.33475259
141MAP3K60.27406260
142SGK20.26633560
143LATS10.25904546
144TSSK60.24386880
145PRKCD0.24211903
146PRKCZ0.23470124
147TAOK10.22120657
148TTN0.21237970
149PRKCH0.20249009
150PRKCA0.19585565
151PRKDC0.18927232
152PRKAA10.18488197

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009805.16656726
2Phenylalanine metabolism_Homo sapiens_hsa003604.68232743
3Chemical carcinogenesis_Homo sapiens_hsa052044.05764882
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.97971236
5Nicotine addiction_Homo sapiens_hsa050333.88769162
6Tyrosine metabolism_Homo sapiens_hsa003503.38982308
7beta-Alanine metabolism_Homo sapiens_hsa004102.82998567
8Glutathione metabolism_Homo sapiens_hsa004802.70847190
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.45192863
10GABAergic synapse_Homo sapiens_hsa047272.41861657
11Taste transduction_Homo sapiens_hsa047422.40947145
12Glutamatergic synapse_Homo sapiens_hsa047242.34582835
13Morphine addiction_Homo sapiens_hsa050322.32696444
14Amphetamine addiction_Homo sapiens_hsa050312.16813298
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.13294354
16Circadian entrainment_Homo sapiens_hsa047132.11901678
17Olfactory transduction_Homo sapiens_hsa047402.06103903
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.03733794
19Phototransduction_Homo sapiens_hsa047441.98810448
20Salivary secretion_Homo sapiens_hsa049701.92643785
21Serotonergic synapse_Homo sapiens_hsa047261.90347606
22Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.86420454
23Retinol metabolism_Homo sapiens_hsa008301.84479104
24Insulin secretion_Homo sapiens_hsa049111.83706602
25Renin secretion_Homo sapiens_hsa049241.74362127
26Tight junction_Homo sapiens_hsa045301.71367314
27Gastric acid secretion_Homo sapiens_hsa049711.68467451
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.67397798
29Calcium signaling pathway_Homo sapiens_hsa040201.66957310
30Vitamin B6 metabolism_Homo sapiens_hsa007501.66242879
31Synaptic vesicle cycle_Homo sapiens_hsa047211.63485511
32Huntingtons disease_Homo sapiens_hsa050161.61365032
33Dorso-ventral axis formation_Homo sapiens_hsa043201.58744424
34Long-term potentiation_Homo sapiens_hsa047201.55953762
35Ether lipid metabolism_Homo sapiens_hsa005651.55219073
36Cocaine addiction_Homo sapiens_hsa050301.52572190
37Caffeine metabolism_Homo sapiens_hsa002321.48860620
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.47661108
39Cardiac muscle contraction_Homo sapiens_hsa042601.46489070
40Axon guidance_Homo sapiens_hsa043601.45167897
41Dopaminergic synapse_Homo sapiens_hsa047281.44998637
42Collecting duct acid secretion_Homo sapiens_hsa049661.42969627
43Oxidative phosphorylation_Homo sapiens_hsa001901.42911530
44ABC transporters_Homo sapiens_hsa020101.41405411
45Sphingolipid metabolism_Homo sapiens_hsa006001.33166225
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.33006138
47Fatty acid degradation_Homo sapiens_hsa000711.30618541
48Long-term depression_Homo sapiens_hsa047301.30123929
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.29513109
50Peroxisome_Homo sapiens_hsa041461.25513267
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.23478918
52Oxytocin signaling pathway_Homo sapiens_hsa049211.23375764
53cAMP signaling pathway_Homo sapiens_hsa040241.22713666
54Alzheimers disease_Homo sapiens_hsa050101.17355370
55Cholinergic synapse_Homo sapiens_hsa047251.09586480
56Fatty acid biosynthesis_Homo sapiens_hsa000611.09055342
57Vascular smooth muscle contraction_Homo sapiens_hsa042701.08946769
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.01873275
59cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01076771
60Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.00901104
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.00159147
62Aldosterone synthesis and secretion_Homo sapiens_hsa049250.97741439
63Linoleic acid metabolism_Homo sapiens_hsa005910.97715416
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.96056314
65Pancreatic secretion_Homo sapiens_hsa049720.93724505
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.90367591
67Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.90287624
68Starch and sucrose metabolism_Homo sapiens_hsa005000.88599099
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.87546472
70Notch signaling pathway_Homo sapiens_hsa043300.86328119
71Mineral absorption_Homo sapiens_hsa049780.84632482
72Ovarian steroidogenesis_Homo sapiens_hsa049130.83305151
73Parkinsons disease_Homo sapiens_hsa050120.82265836
74Estrogen signaling pathway_Homo sapiens_hsa049150.81653897
75Wnt signaling pathway_Homo sapiens_hsa043100.80451864
76Melanogenesis_Homo sapiens_hsa049160.79512926
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77931417
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77212637
79Adherens junction_Homo sapiens_hsa045200.76882915
80Fatty acid elongation_Homo sapiens_hsa000620.75789187
81Hedgehog signaling pathway_Homo sapiens_hsa043400.74552317
82Circadian rhythm_Homo sapiens_hsa047100.72404222
83Ras signaling pathway_Homo sapiens_hsa040140.69754837
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69159683
85Arginine and proline metabolism_Homo sapiens_hsa003300.68881232
86Autoimmune thyroid disease_Homo sapiens_hsa053200.68474587
87Vibrio cholerae infection_Homo sapiens_hsa051100.68070607
88Gap junction_Homo sapiens_hsa045400.66797209
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.66472786
90Thyroid hormone synthesis_Homo sapiens_hsa049180.66135366
91Hippo signaling pathway_Homo sapiens_hsa043900.65513219
92Type II diabetes mellitus_Homo sapiens_hsa049300.65241522
93Basal transcription factors_Homo sapiens_hsa030220.65190814
94Rheumatoid arthritis_Homo sapiens_hsa053230.64470058
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.63592897
96Arachidonic acid metabolism_Homo sapiens_hsa005900.61974187
97PPAR signaling pathway_Homo sapiens_hsa033200.61829211
98GnRH signaling pathway_Homo sapiens_hsa049120.60736377
99Glucagon signaling pathway_Homo sapiens_hsa049220.58841337
100Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57823878
101MAPK signaling pathway_Homo sapiens_hsa040100.57290875
102Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55653492
103Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52189512
104Dilated cardiomyopathy_Homo sapiens_hsa054140.52027551
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51851749
106Butanoate metabolism_Homo sapiens_hsa006500.51266943
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.47824666
108Choline metabolism in cancer_Homo sapiens_hsa052310.46495952
109Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45285233
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.44961298
111Fanconi anemia pathway_Homo sapiens_hsa034600.44846523
112Inositol phosphate metabolism_Homo sapiens_hsa005620.43303514
113ErbB signaling pathway_Homo sapiens_hsa040120.42179975
114Steroid biosynthesis_Homo sapiens_hsa001000.41121335
115Basal cell carcinoma_Homo sapiens_hsa052170.40352898
116Histidine metabolism_Homo sapiens_hsa003400.40207794
117Melanoma_Homo sapiens_hsa052180.40026500
118Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39496337
119Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.38208437
120Rap1 signaling pathway_Homo sapiens_hsa040150.37550875
121Primary bile acid biosynthesis_Homo sapiens_hsa001200.37016770
122Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36145126
123Metabolic pathways_Homo sapiens_hsa011000.35543445
124Pyruvate metabolism_Homo sapiens_hsa006200.35520519
125Oocyte meiosis_Homo sapiens_hsa041140.35381990
126Hepatitis C_Homo sapiens_hsa051600.35099260
127Glycerolipid metabolism_Homo sapiens_hsa005610.34939769
128Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34261690
129Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33135451
130Protein export_Homo sapiens_hsa030600.32277428
131Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30529279
132Bile secretion_Homo sapiens_hsa049760.28719434
133Arginine biosynthesis_Homo sapiens_hsa002200.26416853
134Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25724692
135Insulin resistance_Homo sapiens_hsa049310.23744536
136Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22777148
137Complement and coagulation cascades_Homo sapiens_hsa046100.20726253
138Propanoate metabolism_Homo sapiens_hsa006400.18411203
139Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.17814317
140Drug metabolism - other enzymes_Homo sapiens_hsa009830.17529903
141Folate biosynthesis_Homo sapiens_hsa007900.17467603
142Amoebiasis_Homo sapiens_hsa051460.12569207
143Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.12373617
144Tryptophan metabolism_Homo sapiens_hsa003800.12361064

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