CFAP54

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ventricular system development (GO:0021591)9.42698702
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.19807829
3motile cilium assembly (GO:0044458)7.54419379
4left/right axis specification (GO:0070986)7.03141688
5secondary metabolite biosynthetic process (GO:0044550)6.50630267
6melanin biosynthetic process (GO:0042438)6.50018048
7GTP biosynthetic process (GO:0006183)6.41479916
8intraciliary transport (GO:0042073)6.40136462
9nucleoside diphosphate phosphorylation (GO:0006165)6.24051421
10melanin metabolic process (GO:0006582)5.99968541
11cilium organization (GO:0044782)5.74582323
12UTP biosynthetic process (GO:0006228)5.47938560
13cilium assembly (GO:0042384)5.39635582
14sperm motility (GO:0030317)5.02967026
15UTP metabolic process (GO:0046051)4.95472098
16regulation of cilium movement (GO:0003352)4.84301912
17microtubule bundle formation (GO:0001578)4.66072903
18cilium morphogenesis (GO:0060271)4.62238499
19cellular component assembly involved in morphogenesis (GO:0010927)4.57862974
20tryptophan catabolic process (GO:0006569)4.54244743
21indole-containing compound catabolic process (GO:0042436)4.54244743
22indolalkylamine catabolic process (GO:0046218)4.54244743
23kynurenine metabolic process (GO:0070189)4.39663380
24multicellular organism reproduction (GO:0032504)4.31264193
25microtubule-based movement (GO:0007018)4.27333909
26interkinetic nuclear migration (GO:0022027)4.20841068
27positive regulation of developmental pigmentation (GO:0048087)4.16581474
28behavioral response to nicotine (GO:0035095)4.16397875
29fusion of sperm to egg plasma membrane (GO:0007342)4.14221376
30regulation of establishment of cell polarity (GO:2000114)4.13524000
31guanosine-containing compound biosynthetic process (GO:1901070)4.11772053
32acrosome reaction (GO:0007340)4.07004930
33protein localization to cilium (GO:0061512)4.05793876
34acrosome assembly (GO:0001675)4.03740967
35spermatid development (GO:0007286)4.02267535
36indolalkylamine metabolic process (GO:0006586)4.01096577
37CTP metabolic process (GO:0046036)3.95937575
38CTP biosynthetic process (GO:0006241)3.95937575
39piRNA metabolic process (GO:0034587)3.92408157
40neural tube formation (GO:0001841)3.92356047
41tryptophan metabolic process (GO:0006568)3.91438551
42gamma-aminobutyric acid transport (GO:0015812)3.89084737
43L-fucose catabolic process (GO:0042355)3.88458407
44fucose catabolic process (GO:0019317)3.88458407
45L-fucose metabolic process (GO:0042354)3.88458407
46snRNA transcription (GO:0009301)3.87261788
47endosome to melanosome transport (GO:0035646)3.87207554
48endosome to pigment granule transport (GO:0043485)3.87207554
49regulation of hippo signaling (GO:0035330)3.74374795
50single fertilization (GO:0007338)3.73906975
51negative regulation of sodium ion transport (GO:0010766)3.73684316
52oxidative demethylation (GO:0070989)3.71305189
53negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.69930719
54negative regulation of translation, ncRNA-mediated (GO:0040033)3.69930719
55regulation of translation, ncRNA-mediated (GO:0045974)3.69930719
56cell projection assembly (GO:0030031)3.68340879
57establishment of protein localization to Golgi (GO:0072600)3.66855416
58left/right pattern formation (GO:0060972)3.65877071
59regulation of establishment or maintenance of cell polarity (GO:0032878)3.62836843
60nucleotide phosphorylation (GO:0046939)3.57590850
61sperm-egg recognition (GO:0035036)3.56250059
62negative regulation of inclusion body assembly (GO:0090084)3.47185878
63male meiosis (GO:0007140)3.44743442
64pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.43710070
65cytoplasmic mRNA processing body assembly (GO:0033962)3.40669101
66regulation of gene silencing by RNA (GO:0060966)3.38376512
67regulation of posttranscriptional gene silencing (GO:0060147)3.38376512
68regulation of gene silencing by miRNA (GO:0060964)3.38376512
69negative regulation of protein localization to cell surface (GO:2000009)3.36894682
70negative regulation of systemic arterial blood pressure (GO:0003085)3.34935498
71plasma membrane fusion (GO:0045026)3.32838623
72protein K48-linked deubiquitination (GO:0071108)3.31081617
73negative regulation of cytosolic calcium ion concentration (GO:0051481)3.29615299
74monoubiquitinated protein deubiquitination (GO:0035520)3.29147013
75sperm capacitation (GO:0048240)3.27736513
76flavonoid metabolic process (GO:0009812)3.25127332
77detection of light stimulus involved in visual perception (GO:0050908)3.24033330
78detection of light stimulus involved in sensory perception (GO:0050962)3.24033330
79cell-cell recognition (GO:0009988)3.22933628
80reproduction (GO:0000003)3.17945566
81sulfation (GO:0051923)3.17932005
82cardiovascular system development (GO:0072358)3.17380565
83pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.17124505
84indole-containing compound metabolic process (GO:0042430)3.16288358
85signal peptide processing (GO:0006465)3.15660036
86phospholipid translocation (GO:0045332)3.14516184
87lipid translocation (GO:0034204)3.14516184
88one-carbon compound transport (GO:0019755)3.14439051
89cell wall macromolecule catabolic process (GO:0016998)3.12901676
90cell wall macromolecule metabolic process (GO:0044036)3.12901676
91photoreceptor cell maintenance (GO:0045494)3.12401644
92pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.12104989
93startle response (GO:0001964)3.10280397
94positive regulation of meiosis (GO:0045836)3.08971871
95fertilization (GO:0009566)3.08493141
96binding of sperm to zona pellucida (GO:0007339)3.06437808
97nucleoside diphosphate metabolic process (GO:0009132)3.01892298
98centriole assembly (GO:0098534)3.00954451
99cellular ketone body metabolic process (GO:0046950)2.98077271
100smoothened signaling pathway (GO:0007224)2.96255857
101pericardium development (GO:0060039)2.93365808
102developmental pigmentation (GO:0048066)2.93231687
103synaptic vesicle docking involved in exocytosis (GO:0016081)2.92828478
104endocardial cushion development (GO:0003197)2.92235380
105centriole replication (GO:0007099)2.90724419
106otic vesicle formation (GO:0030916)2.89066669
107regulation of pigment cell differentiation (GO:0050932)2.88229648
108male meiosis I (GO:0007141)2.87319687
109thyroid hormone metabolic process (GO:0042403)2.85920565
110positive regulation of meiotic cell cycle (GO:0051446)2.85778039
111photoreceptor cell differentiation (GO:0046530)2.84201435
112eye photoreceptor cell differentiation (GO:0001754)2.84201435
113regulation of short-term neuronal synaptic plasticity (GO:0048172)2.83805012
114protein polyglutamylation (GO:0018095)2.83539148
115microtubule severing (GO:0051013)2.82772443
116serotonin metabolic process (GO:0042428)2.82243490
117membrane depolarization during action potential (GO:0086010)2.82096871
118spinal cord motor neuron differentiation (GO:0021522)2.79270377
119synaptonemal complex organization (GO:0070193)2.79153354
120protein K63-linked deubiquitination (GO:0070536)2.78928744
121protein targeting to vacuole (GO:0006623)2.76292314
122protein targeting to lysosome (GO:0006622)2.76292314
123establishment of protein localization to vacuole (GO:0072666)2.76292314
124meiotic cell cycle (GO:0051321)2.76280717
125lateral ventricle development (GO:0021670)2.72907562
126brain morphogenesis (GO:0048854)2.72459481
127primary amino compound metabolic process (GO:1901160)2.72304843
128appendage development (GO:0048736)2.72168839
129limb development (GO:0060173)2.72168839
130NAD biosynthetic process (GO:0009435)2.71573713
131neuronal action potential (GO:0019228)2.71448824
132regulation of microtubule-based movement (GO:0060632)2.71355225
133detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.68436648
134calcium ion-dependent exocytosis (GO:0017156)2.63822915
135ketone body metabolic process (GO:1902224)2.62095504
136behavioral response to ethanol (GO:0048149)2.61265525
137nonmotile primary cilium assembly (GO:0035058)2.61225525
138DNA methylation involved in gamete generation (GO:0043046)2.61152753
139retinal rod cell development (GO:0046548)2.59816258
140determination of left/right symmetry (GO:0007368)2.58891533
141retinal cone cell development (GO:0046549)2.58812673
142spermatogenesis (GO:0007283)2.58197439
143membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.57586667
144pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.57177487
145male gamete generation (GO:0048232)2.56935752
146nucleus localization (GO:0051647)2.55427957
147regulation of respiratory system process (GO:0044065)2.54562681
148reflex (GO:0060004)2.54073804
149negative regulation of mast cell activation (GO:0033004)2.53583840
150response to pheromone (GO:0019236)2.53542277
151cellular biogenic amine catabolic process (GO:0042402)2.52142201
152amine catabolic process (GO:0009310)2.52142201
153protein K11-linked deubiquitination (GO:0035871)2.51549293
154peristalsis (GO:0030432)2.50169248
155regulation of mononuclear cell migration (GO:0071675)2.49268309
156detection of calcium ion (GO:0005513)2.48800734
157determination of bilateral symmetry (GO:0009855)2.47594712
158negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.47301955
159regulation of sarcomere organization (GO:0060297)2.46790971
160cornea development in camera-type eye (GO:0061303)2.45712777
161regulation of macrophage chemotaxis (GO:0010758)2.43590551
162regulation of male gonad development (GO:2000018)2.43508101
163ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.42550417
164positive regulation of CREB transcription factor activity (GO:0032793)2.42259832
165specification of symmetry (GO:0009799)2.42232701
166gamete generation (GO:0007276)2.41328078
167regulation of mesoderm development (GO:2000380)2.40410941
168regulation of inclusion body assembly (GO:0090083)2.38714377
169secondary metabolic process (GO:0019748)2.37600957
170oxygen transport (GO:0015671)2.34720009
171regulation of centriole replication (GO:0046599)2.33722781
172organelle assembly (GO:0070925)2.32919315
173germ cell development (GO:0007281)2.32355656
174regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.31583489
175multicellular organismal aging (GO:0010259)2.30142210
176embryonic camera-type eye development (GO:0031076)2.28409515
177vocalization behavior (GO:0071625)2.27590373
178cilium or flagellum-dependent cell motility (GO:0001539)14.1474708
179cilium movement (GO:0003341)13.6593746
180axonemal dynein complex assembly (GO:0070286)12.3976945
181epithelial cilium movement (GO:0003351)10.7527646
182axoneme assembly (GO:0035082)10.4928138

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.87092454
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.36489192
3GBX2_23144817_ChIP-Seq_PC3_Human3.03762960
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.00882427
5ZNF274_21170338_ChIP-Seq_K562_Hela2.76837885
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.65321099
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.40503788
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.21953228
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.15192844
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.14911666
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.14505873
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.13237846
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.03374748
14SALL1_21062744_ChIP-ChIP_HESCs_Human1.98189096
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.94280555
16SMAD4_21799915_ChIP-Seq_A2780_Human1.93910690
17SUZ12_27294783_Chip-Seq_NPCs_Mouse1.93609040
18EWS_26573619_Chip-Seq_HEK293_Human1.92777571
19RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89610894
20CBX2_27304074_Chip-Seq_ESCs_Mouse1.88320098
21TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.86896377
22P300_19829295_ChIP-Seq_ESCs_Human1.86130885
23RNF2_27304074_Chip-Seq_NSC_Mouse1.81830565
24PCGF2_27294783_Chip-Seq_NPCs_Mouse1.74787219
25TP53_16413492_ChIP-PET_HCT116_Human1.74515052
26NFE2_27457419_Chip-Seq_LIVER_Mouse1.74413382
27PIAS1_25552417_ChIP-Seq_VCAP_Human1.72922133
28AR_21572438_ChIP-Seq_LNCaP_Human1.71315595
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68742069
30EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.65848839
31TAF15_26573619_Chip-Seq_HEK293_Human1.65302109
32NANOG_18555785_Chip-Seq_ESCs_Mouse1.64057625
33SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.63020798
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61055708
35JARID2_20064375_ChIP-Seq_MESCs_Mouse1.59451955
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.56057295
37FUS_26573619_Chip-Seq_HEK293_Human1.56056743
38ER_23166858_ChIP-Seq_MCF-7_Human1.54377264
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.53247564
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52701772
41E2F1_18555785_Chip-Seq_ESCs_Mouse1.51725571
42AHR_22903824_ChIP-Seq_MCF-7_Human1.50739677
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.50645356
44P53_22387025_ChIP-Seq_ESCs_Mouse1.50502916
45PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.50115089
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50077189
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.49448928
48REST_21632747_ChIP-Seq_MESCs_Mouse1.49435225
49ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.49220371
50DROSHA_22980978_ChIP-Seq_HELA_Human1.46913761
51STAT3_18555785_Chip-Seq_ESCs_Mouse1.46792195
52CBP_20019798_ChIP-Seq_JUKART_Human1.46778576
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46778576
54POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.46597061
55TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46597061
56EZH2_27294783_Chip-Seq_ESCs_Mouse1.46558918
57NR3C1_21868756_ChIP-Seq_MCF10A_Human1.45934484
58EZH2_27304074_Chip-Seq_ESCs_Mouse1.45437429
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45316912
60STAT3_23295773_ChIP-Seq_U87_Human1.44844036
61MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.44071555
62BCAT_22108803_ChIP-Seq_LS180_Human1.43377079
63ZNF217_24962896_ChIP-Seq_MCF-7_Human1.43018655
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.42405862
65SUZ12_18555785_Chip-Seq_ESCs_Mouse1.42387006
66SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.41486959
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.41437277
68VDR_22108803_ChIP-Seq_LS180_Human1.41332990
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40855801
70MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.40285177
71SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.39715532
72TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.39706837
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39419584
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38273859
75TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38083538
76AR_25329375_ChIP-Seq_VCAP_Human1.36966539
77SUZ12_27294783_Chip-Seq_ESCs_Mouse1.36941521
78TCF4_23295773_ChIP-Seq_U87_Human1.36798243
79P300_18555785_Chip-Seq_ESCs_Mouse1.36360428
80CMYC_18555785_Chip-Seq_ESCs_Mouse1.36120369
81SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.35891010
82EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.35318686
83SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.33095255
84TCF4_22108803_ChIP-Seq_LS180_Human1.31835267
85TAL1_26923725_Chip-Seq_HPCs_Mouse1.31763797
86EED_16625203_ChIP-ChIP_MESCs_Mouse1.30958980
87OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30400391
88OCT4_18555785_Chip-Seq_ESCs_Mouse1.29794738
89SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.29534784
90CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28772956
91SOX2_18555785_Chip-Seq_ESCs_Mouse1.28505828
92PRDM14_20953172_ChIP-Seq_ESCs_Human1.28388732
93JARID2_20075857_ChIP-Seq_MESCs_Mouse1.27098632
94RNF2_27304074_Chip-Seq_ESCs_Mouse1.26271843
95ZFX_18555785_Chip-Seq_ESCs_Mouse1.25857096
96NMYC_18555785_Chip-Seq_ESCs_Mouse1.25070251
97CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.24943218
98MTF2_20144788_ChIP-Seq_MESCs_Mouse1.23151343
99MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22955252
100SOX2_21211035_ChIP-Seq_LN229_Gbm1.22526102
101LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22479613
102BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.21852112
103RNF2_18974828_ChIP-Seq_MESCs_Mouse1.21687116
104EZH2_18974828_ChIP-Seq_MESCs_Mouse1.21687116
105RUNX1_27457419_Chip-Seq_LIVER_Mouse1.21547303
106SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21468501
107TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21215371
108ESRRB_18555785_Chip-Seq_ESCs_Mouse1.19519640
109UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19334480
110NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.19272177
111SMAD4_21741376_ChIP-Seq_EPCs_Human1.18883450
112PU1_27457419_Chip-Seq_LIVER_Mouse1.18204085
113FOXM1_26456572_ChIP-Seq_MCF-7_Human1.17952166
114FLI1_21867929_ChIP-Seq_TH2_Mouse1.17296737
115EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16683241
116IGF1R_20145208_ChIP-Seq_DFB_Human1.16580410
117ARNT_22903824_ChIP-Seq_MCF-7_Human1.15458615
118GATA1_26923725_Chip-Seq_HPCs_Mouse1.15148414
119RUNX2_22187159_ChIP-Seq_PCA_Human1.14943548
120KDM2B_26808549_Chip-Seq_REH_Human1.14442703
121RXR_22108803_ChIP-Seq_LS180_Human1.14435812
122KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13139853
123CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10903318
124IRF1_19129219_ChIP-ChIP_H3396_Human1.08633456
125HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.05239918
126SMAD3_21741376_ChIP-Seq_ESCs_Human1.01970006
127NANOG_19829295_ChIP-Seq_ESCs_Human1.01618108
128SOX2_19829295_ChIP-Seq_ESCs_Human1.01618108
129TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00131841
130CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99278471
131NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.99212327
132NRF2_20460467_ChIP-Seq_MEFs_Mouse0.99212327
133FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99134122
134SMAD3_21741376_ChIP-Seq_HESCs_Human0.98997335
135CDX2_22108803_ChIP-Seq_LS180_Human0.98788140
136FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98380842
137AR_19668381_ChIP-Seq_PC3_Human0.97773286

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color6.46299853
2MP0000569_abnormal_digit_pigmentation5.20238574
3MP0005171_absent_coat_pigmentation4.28941745
4MP0000372_irregular_coat_pigmentation4.15143325
5MP0005410_abnormal_fertilization3.62280069
6MP0005646_abnormal_pituitary_gland3.50730274
7MP0003195_calcinosis3.14084354
8MP0004043_abnormal_pH_regulation3.04785336
9MP0008057_abnormal_DNA_replication3.03529131
10MP0003646_muscle_fatigue2.91476530
11MP0008004_abnormal_stomach_pH2.74646964
12MP0005623_abnormal_meninges_morphology2.57976338
13MP0009046_muscle_twitch2.39603432
14MP0000383_abnormal_hair_follicle2.35542876
15MP0004381_abnormal_hair_follicle2.35235183
16MP0002102_abnormal_ear_morphology2.28870311
17MP0000427_abnormal_hair_cycle2.25876171
18MP0008961_abnormal_basal_metabolism2.24728615
19MP0002653_abnormal_ependyma_morphology2.19198750
20MP0001986_abnormal_taste_sensitivity2.15343138
21MP0004859_abnormal_synaptic_plasticity2.13893960
22MP0002638_abnormal_pupillary_reflex2.06306680
23MP0003890_abnormal_embryonic-extraembry2.05877434
24MP0001984_abnormal_olfaction2.03529975
25MP0001968_abnormal_touch/_nociception1.94794093
26MP0002736_abnormal_nociception_after1.93448245
27MP0003698_abnormal_male_reproductive1.92760889
28MP0002095_abnormal_skin_pigmentation1.87977605
29MP0005423_abnormal_somatic_nervous1.86001261
30MP0003880_abnormal_central_pattern1.84292342
31MP0000015_abnormal_ear_pigmentation1.80079310
32MP0001440_abnormal_grooming_behavior1.76813414
33MP0009745_abnormal_behavioral_response1.76705966
34MP0006292_abnormal_olfactory_placode1.76697681
35MP0003878_abnormal_ear_physiology1.76113695
36MP0005377_hearing/vestibular/ear_phenot1.76113695
37MP0004133_heterotaxia1.73954848
38MP0008877_abnormal_DNA_methylation1.69482062
39MP0002837_dystrophic_cardiac_calcinosis1.66003269
40MP0001188_hyperpigmentation1.64096266
41MP0002572_abnormal_emotion/affect_behav1.55781615
42MP0001501_abnormal_sleep_pattern1.55313764
43MP0001486_abnormal_startle_reflex1.55179779
44MP0004145_abnormal_muscle_electrophysio1.54675537
45MP0001929_abnormal_gametogenesis1.54072355
46MP0003635_abnormal_synaptic_transmissio1.54009658
47MP0005551_abnormal_eye_electrophysiolog1.52863866
48MP0004130_abnormal_muscle_cell1.50309368
49MP0005075_abnormal_melanosome_morpholog1.47882136
50MP0002557_abnormal_social/conspecific_i1.45486125
51MP0003787_abnormal_imprinting1.44564009
52MP0002938_white_spotting1.43036282
53MP0002064_seizures1.40857433
54MP0005645_abnormal_hypothalamus_physiol1.37854561
55MP0005409_darkened_coat_color1.35333911
56MP0003252_abnormal_bile_duct1.34872090
57MP0002063_abnormal_learning/memory/cond1.34492952
58MP0001324_abnormal_eye_pigmentation1.31931139
59MP0005253_abnormal_eye_physiology1.30235193
60MP0002272_abnormal_nervous_system1.29325091
61MP0002734_abnormal_mechanical_nocicepti1.27908233
62MP0003045_fibrosis1.26399393
63MP0000778_abnormal_nervous_system1.26293179
64MP0005408_hypopigmentation1.25070594
65MP0010386_abnormal_urinary_bladder1.24139345
66MP0010678_abnormal_skin_adnexa1.23368066
67MP0002160_abnormal_reproductive_system1.20195108
68MP0001970_abnormal_pain_threshold1.20140223
69MP0001485_abnormal_pinna_reflex1.18694209
70MP0008872_abnormal_physiological_respon1.18179236
71MP0006276_abnormal_autonomic_nervous1.17295944
72MP0006072_abnormal_retinal_apoptosis1.12004604
73MP0004270_analgesia1.11256602
74MP0002733_abnormal_thermal_nociception1.10858097
75MP0002210_abnormal_sex_determination1.10676703
76MP0005266_abnormal_metabolism1.09920675
77MP0005257_abnormal_intraocular_pressure1.08753697
78MP0003950_abnormal_plasma_membrane1.07814347
79MP0004215_abnormal_myocardial_fiber1.07483344
80MP0000631_abnormal_neuroendocrine_gland1.06361735
81MP0003122_maternal_imprinting1.04678893
82MP0000026_abnormal_inner_ear1.03062225
83MP0003690_abnormal_glial_cell1.02935775
84MP0004742_abnormal_vestibular_system1.02894478
85MP0002067_abnormal_sensory_capabilities1.02698265
86MP0000230_abnormal_systemic_arterial1.00964116
87MP0002876_abnormal_thyroid_physiology1.00563295
88MP0001963_abnormal_hearing_physiology1.00471467
89MP0005167_abnormal_blood-brain_barrier0.99123051
90MP0004147_increased_porphyrin_level0.98939070
91MP0002735_abnormal_chemical_nociception0.98695625
92MP0005195_abnormal_posterior_eye0.98074501
93MP0004885_abnormal_endolymph0.98001766
94MP0003119_abnormal_digestive_system0.97625400
95MP0002928_abnormal_bile_duct0.96927810
96MP0000371_diluted_coat_color0.96777296
97MP0004858_abnormal_nervous_system0.96260605
98MP0000049_abnormal_middle_ear0.93968715
99MP0002168_other_aberrant_phenotype0.92186579
100MP0001502_abnormal_circadian_rhythm0.91820019
101MP0008875_abnormal_xenobiotic_pharmacok0.91449179
102MP0004142_abnormal_muscle_tone0.90489406
103MP0005389_reproductive_system_phenotype0.90412083
104MP0003137_abnormal_impulse_conducting0.89447485
105MP0000538_abnormal_urinary_bladder0.87125820
106MP0002161_abnormal_fertility/fecundity0.86808241
107MP0002229_neurodegeneration0.84527229
108MP0002282_abnormal_trachea_morphology0.84283931
109MP0002075_abnormal_coat/hair_pigmentati0.84077963
110MP0005174_abnormal_tail_pigmentation0.83124794
111MP0000955_abnormal_spinal_cord0.82895323
112MP0005448_abnormal_energy_balance0.82814371
113MP0002009_preneoplasia0.80440227
114MP0004924_abnormal_behavior0.80112130
115MP0005386_behavior/neurological_phenoty0.80112130
116MP0002249_abnormal_larynx_morphology0.79438693
117MP0001177_atelectasis0.79257864
118MP0003938_abnormal_ear_development0.78379613
119MP0005187_abnormal_penis_morphology0.78271251
120MP0005085_abnormal_gallbladder_physiolo0.74355513
121MP0009697_abnormal_copulation0.74348855
122MP0005310_abnormal_salivary_gland0.72414261
123MP0002184_abnormal_innervation0.71637363
124MP0005379_endocrine/exocrine_gland_phen0.71227590
125MP0000653_abnormal_sex_gland0.71183315
126MP0001145_abnormal_male_reproductive0.71153325
127MP0009115_abnormal_fat_cell0.70496454
128MP0003943_abnormal_hepatobiliary_system0.70404611
129MP0005391_vision/eye_phenotype0.70032517
130MP0002752_abnormal_somatic_nervous0.69630912
131MP0001186_pigmentation_phenotype0.69571833
132MP0002152_abnormal_brain_morphology0.69485546
133MP0003937_abnormal_limbs/digits/tail_de0.69294242
134MP0002882_abnormal_neuron_morphology0.69030313
135MP0003879_abnormal_hair_cell0.68614362
136MP0002090_abnormal_vision0.68164447
137MP0003633_abnormal_nervous_system0.68069800
138MP0003634_abnormal_glial_cell0.67498632

Predicted human phenotypes

RankGene SetZ-score
1Rhinitis (HP:0012384)9.10716996
2Abnormal respiratory motile cilium morphology (HP:0005938)8.01529355
3Abnormal respiratory epithelium morphology (HP:0012253)8.01529355
4Absent/shortened dynein arms (HP:0200106)7.92225100
5Dynein arm defect of respiratory motile cilia (HP:0012255)7.92225100
6Chronic bronchitis (HP:0004469)6.68874892
7Bronchiectasis (HP:0002110)4.97724868
8Genetic anticipation (HP:0003743)4.86494097
9Pancreatic fibrosis (HP:0100732)4.65930404
10True hermaphroditism (HP:0010459)4.51497858
11Hyperventilation (HP:0002883)4.43008884
12Nephronophthisis (HP:0000090)3.91265587
13Progressive cerebellar ataxia (HP:0002073)3.87930290
14Protruding tongue (HP:0010808)3.86237905
15Tubulointerstitial nephritis (HP:0001970)3.70629077
16Nasal polyposis (HP:0100582)3.60928746
17Medial flaring of the eyebrow (HP:0010747)3.41410311
18Gaze-evoked nystagmus (HP:0000640)3.32782796
19Bronchitis (HP:0012387)3.31479849
20Abnormality of midbrain morphology (HP:0002418)3.25669522
21Molar tooth sign on MRI (HP:0002419)3.25669522
22Postaxial foot polydactyly (HP:0001830)3.22086602
23Recurrent sinusitis (HP:0011108)3.19508240
24Pancreatic cysts (HP:0001737)3.19149850
25Median cleft lip (HP:0000161)3.06472521
26Abnormality of the renal medulla (HP:0100957)3.04073337
27Chronic hepatic failure (HP:0100626)3.00634346
28Gait imbalance (HP:0002141)2.93385508
29Clumsiness (HP:0002312)2.90355547
30Congenital primary aphakia (HP:0007707)2.90119579
31Occipital encephalocele (HP:0002085)2.89159979
32Abnormality of the nasal mucosa (HP:0000433)2.88359308
33Congenital hepatic fibrosis (HP:0002612)2.86598885
34Fibular hypoplasia (HP:0003038)2.85956523
35Cystic liver disease (HP:0006706)2.85510947
36Chronic sinusitis (HP:0011109)2.83332860
37Abnormal biliary tract physiology (HP:0012439)2.80385100
38Bile duct proliferation (HP:0001408)2.80385100
39Infertility (HP:0000789)2.74994267
40Nephrogenic diabetes insipidus (HP:0009806)2.68282964
41Aplasia/Hypoplasia of the tongue (HP:0010295)2.66177746
42Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.60309263
43Abnormality of dentin (HP:0010299)2.57833667
44Congenital stationary night blindness (HP:0007642)2.53416170
45Recurrent otitis media (HP:0000403)2.53328365
46Fair hair (HP:0002286)2.53192077
47Blue irides (HP:0000635)2.46707698
48Decreased circulating renin level (HP:0003351)2.44040806
49Abnormality of the fovea (HP:0000493)2.43272110
50Attenuation of retinal blood vessels (HP:0007843)2.43101079
51Febrile seizures (HP:0002373)2.36612468
52Genital tract atresia (HP:0001827)2.35657290
53Birth length less than 3rd percentile (HP:0003561)2.32258449
54Aplasia/Hypoplasia of the fovea (HP:0008060)2.31184372
55Hypoplasia of the fovea (HP:0007750)2.31184372
56Preaxial hand polydactyly (HP:0001177)2.29342302
57Broad-based gait (HP:0002136)2.28114786
58Patellar aplasia (HP:0006443)2.27317371
59Supernumerary spleens (HP:0009799)2.22906065
60Abnormality of the dental root (HP:0006486)2.22875843
61Taurodontia (HP:0000679)2.22875843
62Abnormality of permanent molar morphology (HP:0011071)2.22875843
63Anencephaly (HP:0002323)2.22573600
64Inability to walk (HP:0002540)2.21326408
65Tubular atrophy (HP:0000092)2.19797142
66Postaxial hand polydactyly (HP:0001162)2.19208913
67Hypoplastic labia majora (HP:0000059)2.19056072
68Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.17697667
69Abnormality of alanine metabolism (HP:0010916)2.17697667
70Hyperalaninemia (HP:0003348)2.17697667
71Type II lissencephaly (HP:0007260)2.14974734
72Poor coordination (HP:0002370)2.14306216
73Aplasia/Hypoplasia of the macula (HP:0008059)2.14200622
74Abnormality of molar morphology (HP:0011070)2.13691906
75Abnormality of molar (HP:0011077)2.13691906
76Tubulointerstitial abnormality (HP:0001969)2.13637367
77Increased neuronal autofluorescent lipopigment (HP:0002074)2.12710970
78Stage 5 chronic kidney disease (HP:0003774)2.11753092
79Large for gestational age (HP:0001520)2.11525272
80Bony spicule pigmentary retinopathy (HP:0007737)2.10419650
81Abnormality of the dental pulp (HP:0006479)2.07570439
82Aplasia/Hypoplasia of the patella (HP:0006498)2.07231834
83Abolished electroretinogram (ERG) (HP:0000550)2.06803877
84Male pseudohermaphroditism (HP:0000037)2.05396093
85Abnormality of the labia majora (HP:0012881)2.04345528
86Facial cleft (HP:0002006)2.03959876
87Vaginal atresia (HP:0000148)2.03193406
88Absent speech (HP:0001344)2.01498521
89Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.6989332
90Abnormal respiratory motile cilium physiology (HP:0012261)10.9313146
91Abnormal ciliary motility (HP:0012262)10.1086656
92Generalized hypopigmentation of hair (HP:0011358)1.98994249
93Abnormality of the ischium (HP:0003174)1.97902175
94Progressive inability to walk (HP:0002505)1.96434789
95Highly arched eyebrow (HP:0002553)1.95619548
96Lissencephaly (HP:0001339)1.94829724
97Hypoplastic ischia (HP:0003175)1.93311527
98Widely spaced teeth (HP:0000687)1.92627723
99Polydipsia (HP:0001959)1.92610710
100Abnormal drinking behavior (HP:0030082)1.92610710
101Dysmetric saccades (HP:0000641)1.92355531
102Polyuria (HP:0000103)1.91669916
103Cerebellar dysplasia (HP:0007033)1.90757028
104Atelectasis (HP:0100750)1.90142339
105Hypoplasia of the pons (HP:0012110)1.89529825
106Aplasia/Hypoplasia affecting the retina (HP:0008061)1.86046219
107Aplasia/Hypoplasia of the lens (HP:0008063)1.85277336
108Abnormality of the renal cortex (HP:0011035)1.83585478
109Abnormality of the pons (HP:0007361)1.83159512
110Short foot (HP:0001773)1.81440335
111Macroglossia (HP:0000158)1.81319315
112Preaxial foot polydactyly (HP:0001841)1.80896065
113Oculomotor apraxia (HP:0000657)1.80337018
114Decreased central vision (HP:0007663)1.77534535
115Dandy-Walker malformation (HP:0001305)1.76314111
116Small hand (HP:0200055)1.75955823
117Chorioretinal atrophy (HP:0000533)1.75820500
118Aplasia/Hypoplasia of the fibula (HP:0006492)1.73819300
119Increased corneal curvature (HP:0100692)1.73529843
120Keratoconus (HP:0000563)1.73529843
121Sclerocornea (HP:0000647)1.70211698
122Focal motor seizures (HP:0011153)1.69549421
123Broad distal phalanx of finger (HP:0009836)1.69271622
124Focal seizures (HP:0007359)1.67317940
125Bulbous nose (HP:0000414)1.66566618
126Nephropathy (HP:0000112)1.66078511
127Dialeptic seizures (HP:0011146)1.65413417
128Urinary bladder sphincter dysfunction (HP:0002839)1.64628549
129White forelock (HP:0002211)1.60977328
130Patchy hypopigmentation of hair (HP:0011365)1.59285106
131Sex reversal (HP:0012245)1.58515231
132Abnormal sex determination (HP:0012244)1.58515231
133Abnormality of macular pigmentation (HP:0008002)1.58095622
134Abnormality of abdominal situs (HP:0011620)1.57240987
135Abdominal situs inversus (HP:0003363)1.57240987
136Hip dysplasia (HP:0001385)1.53579064
137Epileptic encephalopathy (HP:0200134)1.52733624
13811 pairs of ribs (HP:0000878)1.50717671
139Furrowed tongue (HP:0000221)1.43919945
140Short tibia (HP:0005736)1.43087856
141Ectopic anus (HP:0004397)1.41802406
142Aganglionic megacolon (HP:0002251)1.41700976
143Specific learning disability (HP:0001328)1.37821335
144Aplasia/Hypoplasia of the tibia (HP:0005772)1.37500379
145Hypotelorism (HP:0000601)1.37318428
146Polycystic kidney dysplasia (HP:0000113)1.35625091
147Congenital sensorineural hearing impairment (HP:0008527)1.34943159
148Hypodontia (HP:0000668)1.32154317
149Bell-shaped thorax (HP:0001591)1.30958525
150Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.29421000
151Renal dysplasia (HP:0000110)1.27832735
152Bifid tongue (HP:0010297)1.27701018

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK9.47756169
2MAPK156.70069411
3PNCK5.10911653
4ACVR1B4.38495250
5CASK3.28769855
6MST1R3.17975326
7PDK42.50718986
8PDK32.50718986
9GRK12.36216509
10NTRK32.28739272
11EPHA42.01772134
12CDK31.92051073
13NTRK21.87680386
14MAP2K71.80663211
15TNIK1.69906108
16TLK11.64699228
17TGFBR11.54699721
18OXSR11.51865118
19MST41.50406903
20SGK21.50396295
21TAOK31.49251256
22PTK2B1.44869565
23PDK21.41358003
24INSRR1.40657694
25VRK11.35180959
26BMPR21.34127912
27PRKD31.32974936
28NUAK11.28272304
29WEE11.28167085
30PRPF4B1.26751190
31STK391.24637062
32MARK11.24138481
33CAMK1G1.23731690
34BMPR1B1.22425290
35MAP3K41.21267082
36STK38L1.21152072
37MAPK131.15864987
38DAPK21.15796069
39ZAK1.14663457
40MUSK1.12248953
41NEK61.10658384
42CAMK1D1.08772120
43PLK21.08020423
44PRKCG1.06462483
45SGK4941.05278767
46SGK2231.05278767
47DMPK1.03484068
48PRKCE1.00968085
49PIK3CA1.00665163
50MARK30.98076498
51MKNK20.97064689
52ERBB30.95787593
53IRAK10.93192931
54ADRBK20.92585028
55AKT30.86226283
56CCNB10.85770859
57BRSK20.85540880
58PINK10.83267080
59WNK30.83247919
60MINK10.82292661
61CAMK2A0.82103410
62SGK30.81050972
63YES10.78130776
64MELK0.77643693
65CAMKK20.77398746
66MAP4K20.76464981
67TXK0.76094420
68IRAK30.72868415
69WNK10.70859768
70PRKAA20.68977459
71GRK70.67851113
72MAP3K60.66751445
73IRAK20.66601721
74TEC0.66521311
75SIK30.65050770
76CHUK0.63426324
77MAPK70.63227935
78MAP2K40.63006668
79BRD40.61728351
80STK380.61328721
81MAPKAPK30.60764813
82MAP3K70.60199777
83RPS6KA20.60084209
84NEK20.59971944
85FGFR20.58800116
86LATS10.58749297
87MET0.58423958
88STK110.57937256
89PRKG10.56802020
90ERBB20.54516070
91CDK190.52365810
92BCR0.52110704
93MKNK10.51915614
94CAMK2B0.51615838
95PRKAA10.50941356
96RPS6KA60.50600544
97TIE10.50586196
98PIK3CG0.50069968
99TRPM70.47596795
100CAMK40.47582382
101CAMK10.46679538
102MAPKAPK50.45091976
103CAMKK10.44563712
104OBSCN0.44417761
105CDK80.44403116
106PRKCQ0.43797469
107PKN10.43792912
108MAP2K60.43397726
109FES0.42980134
110CDK50.42529615
111ADRBK10.42401237
112CSNK1A1L0.41803498
113MAP2K10.41739245
114EIF2AK20.41288088
115SGK10.40463665
116BMX0.40119838
117PLK30.40091118
118SIK20.39320367
119GRK50.39246746
120STK160.39122376
121RPS6KA50.38219455
122RIPK40.37537042
123PRKCH0.36857174
124CDK120.36239290
125PRKACA0.35798443
126STK240.35048777
127GSK3A0.34792853
128CSNK1D0.34160951
129WNK40.34067370
130FER0.33989389
131CDC42BPA0.33878560
132CHEK20.33536030
133NLK0.32078740
134PASK0.30017317
135PDGFRB0.29137225
136IKBKB0.28685001
137RPS6KA30.28266856
138STK30.28188254
139PAK30.27794539
140DYRK1A0.27571439
141ROCK20.27549346
142ROCK10.27510575
143SIK10.26794064
144CAMK2D0.26672412
145MAPK110.26628195
146KIT0.26134566
147MARK20.25492613
148PRKCA0.25016292

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.16314433
2Nitrogen metabolism_Homo sapiens_hsa009102.49382986
3Taste transduction_Homo sapiens_hsa047422.47959499
4Olfactory transduction_Homo sapiens_hsa047402.38594704
5Circadian entrainment_Homo sapiens_hsa047132.29206145
6Amphetamine addiction_Homo sapiens_hsa050312.24818439
7ABC transporters_Homo sapiens_hsa020102.20314849
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.18199783
9Glutamatergic synapse_Homo sapiens_hsa047242.13363490
10Morphine addiction_Homo sapiens_hsa050322.13138876
11Phototransduction_Homo sapiens_hsa047442.09336404
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.07997294
13GABAergic synapse_Homo sapiens_hsa047271.99625440
14Insulin secretion_Homo sapiens_hsa049111.98698554
15Tryptophan metabolism_Homo sapiens_hsa003801.98697651
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.95880837
17Butanoate metabolism_Homo sapiens_hsa006501.88323550
18Huntingtons disease_Homo sapiens_hsa050161.84563651
19Serotonergic synapse_Homo sapiens_hsa047261.77990905
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.73319102
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.72964667
22Primary bile acid biosynthesis_Homo sapiens_hsa001201.70811324
23Calcium signaling pathway_Homo sapiens_hsa040201.70770457
24Selenocompound metabolism_Homo sapiens_hsa004501.69398019
25Salivary secretion_Homo sapiens_hsa049701.65675870
26Gastric acid secretion_Homo sapiens_hsa049711.65080119
27Renin secretion_Homo sapiens_hsa049241.63061116
28Vitamin B6 metabolism_Homo sapiens_hsa007501.62878656
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.59344315
30SNARE interactions in vesicular transport_Homo sapiens_hsa041301.54698656
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.51378547
32Cocaine addiction_Homo sapiens_hsa050301.47530793
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.45556179
34Histidine metabolism_Homo sapiens_hsa003401.44002529
35Melanogenesis_Homo sapiens_hsa049161.43971506
36Synaptic vesicle cycle_Homo sapiens_hsa047211.43787784
37Fanconi anemia pathway_Homo sapiens_hsa034601.43102234
38Dopaminergic synapse_Homo sapiens_hsa047281.38175663
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.33263312
40Homologous recombination_Homo sapiens_hsa034401.33005857
41Long-term potentiation_Homo sapiens_hsa047201.32922497
42Circadian rhythm_Homo sapiens_hsa047101.29774439
43Ovarian steroidogenesis_Homo sapiens_hsa049131.26645998
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.24740525
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.23981966
46cAMP signaling pathway_Homo sapiens_hsa040241.23280153
47Lysine degradation_Homo sapiens_hsa003101.18809917
48Estrogen signaling pathway_Homo sapiens_hsa049151.18382130
49Dorso-ventral axis formation_Homo sapiens_hsa043201.16457354
50Tyrosine metabolism_Homo sapiens_hsa003501.15483825
51cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09981835
52Oxytocin signaling pathway_Homo sapiens_hsa049211.08333082
53Cholinergic synapse_Homo sapiens_hsa047251.07408716
54Caffeine metabolism_Homo sapiens_hsa002321.06426162
55Intestinal immune network for IgA production_Homo sapiens_hsa046721.05342346
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.04876078
57Chemical carcinogenesis_Homo sapiens_hsa052041.04829814
58Wnt signaling pathway_Homo sapiens_hsa043101.04466479
59One carbon pool by folate_Homo sapiens_hsa006701.02967434
60Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02802161
61Mineral absorption_Homo sapiens_hsa049781.02612963
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01794222
63Retinol metabolism_Homo sapiens_hsa008301.01365967
64Glycerolipid metabolism_Homo sapiens_hsa005611.01061680
65Aldosterone synthesis and secretion_Homo sapiens_hsa049251.00460520
66Collecting duct acid secretion_Homo sapiens_hsa049661.00318540
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.98885720
68Ether lipid metabolism_Homo sapiens_hsa005650.94020879
69Sphingolipid metabolism_Homo sapiens_hsa006000.93175667
70Basal transcription factors_Homo sapiens_hsa030220.90366427
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.89411638
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.88339275
73Purine metabolism_Homo sapiens_hsa002300.85165137
74Long-term depression_Homo sapiens_hsa047300.85135239
75Glucagon signaling pathway_Homo sapiens_hsa049220.83267275
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.80698789
77Axon guidance_Homo sapiens_hsa043600.80117281
78Propanoate metabolism_Homo sapiens_hsa006400.79873424
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.79241201
80Rheumatoid arthritis_Homo sapiens_hsa053230.77952365
81GnRH signaling pathway_Homo sapiens_hsa049120.76905155
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.75878294
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75053547
84Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75042686
85Arachidonic acid metabolism_Homo sapiens_hsa005900.74528543
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73783574
87beta-Alanine metabolism_Homo sapiens_hsa004100.73083387
88Inositol phosphate metabolism_Homo sapiens_hsa005620.71324412
89Type I diabetes mellitus_Homo sapiens_hsa049400.70514143
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70081958
91Autoimmune thyroid disease_Homo sapiens_hsa053200.68003968
92Hedgehog signaling pathway_Homo sapiens_hsa043400.66316173
93Thyroid hormone synthesis_Homo sapiens_hsa049180.64486309
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64171872
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63437367
96Alcoholism_Homo sapiens_hsa050340.62355491
97Basal cell carcinoma_Homo sapiens_hsa052170.61797907
98Pancreatic secretion_Homo sapiens_hsa049720.60449553
99MAPK signaling pathway_Homo sapiens_hsa040100.60191918
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59206344
101Peroxisome_Homo sapiens_hsa041460.58440705
102Linoleic acid metabolism_Homo sapiens_hsa005910.58158671
103Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.56872682
104Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56725969
105Bile secretion_Homo sapiens_hsa049760.56336969
106Systemic lupus erythematosus_Homo sapiens_hsa053220.55805013
107Gap junction_Homo sapiens_hsa045400.55214622
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.54007332
109Cardiac muscle contraction_Homo sapiens_hsa042600.53881904
110Ras signaling pathway_Homo sapiens_hsa040140.51396531
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51264816
112Fatty acid biosynthesis_Homo sapiens_hsa000610.51255305
113TGF-beta signaling pathway_Homo sapiens_hsa043500.51056278
114Asthma_Homo sapiens_hsa053100.49404587
115ErbB signaling pathway_Homo sapiens_hsa040120.49378986
116Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48301220
117Vibrio cholerae infection_Homo sapiens_hsa051100.48160272
118Choline metabolism in cancer_Homo sapiens_hsa052310.47738321
119Phagosome_Homo sapiens_hsa041450.45752857
120Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.44489247
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42579272
122Graft-versus-host disease_Homo sapiens_hsa053320.41143931
123Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41001495
124Regulation of autophagy_Homo sapiens_hsa041400.40354443
125Type II diabetes mellitus_Homo sapiens_hsa049300.40166483
126Non-homologous end-joining_Homo sapiens_hsa034500.39652305
127Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.38774934
128PPAR signaling pathway_Homo sapiens_hsa033200.37071750
129Dilated cardiomyopathy_Homo sapiens_hsa054140.37018481
130Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36921678
131Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35455178
132Allograft rejection_Homo sapiens_hsa053300.34851048
133Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33678274
134African trypanosomiasis_Homo sapiens_hsa051430.32412817
135Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.29775634
136Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.28653328
137Rap1 signaling pathway_Homo sapiens_hsa040150.28408474
138Hippo signaling pathway_Homo sapiens_hsa043900.26561078

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