CFAP57

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This protein encoded by this gene belongs to the WD repeat-containing family of proteins, which function in the formation of protein-protein complexes in a variety of biological pathways. This family member is thought to function in craniofacial development, possibly in the fusion of lip and palate. A missense mutation in this gene is associated with Van der Woude syndrome 2. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)9.88406388
2plasma membrane fusion (GO:0045026)9.79233766
3cell wall macromolecule catabolic process (GO:0016998)9.42286646
4cell wall macromolecule metabolic process (GO:0044036)9.42286646
5motile cilium assembly (GO:0044458)9.25823385
6binding of sperm to zona pellucida (GO:0007339)9.23869906
7cell-cell recognition (GO:0009988)9.22582135
8acrosome reaction (GO:0007340)9.05697033
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.02584199
10male meiosis (GO:0007140)8.88196282
11reproduction (GO:0000003)8.81159911
12spermatid development (GO:0007286)8.28776562
13regulation of cilium movement (GO:0003352)7.93765801
14synaptonemal complex organization (GO:0070193)7.59597742
15single fertilization (GO:0007338)7.26244450
16synaptonemal complex assembly (GO:0007130)7.11898612
17primary alcohol catabolic process (GO:0034310)6.66936726
18sperm capacitation (GO:0048240)6.60028900
19ventricular system development (GO:0021591)6.35243638
20fertilization (GO:0009566)6.16616804
21negative regulation of inclusion body assembly (GO:0090084)6.11479325
22male meiosis I (GO:0007141)6.04316136
23DNA methylation involved in gamete generation (GO:0043046)6.00548886
24vitamin transmembrane transport (GO:0035461)5.90425167
25ethanol metabolic process (GO:0006067)5.72094948
26spermatogenesis (GO:0007283)5.31343757
27male gamete generation (GO:0048232)5.29129184
28diterpenoid biosynthetic process (GO:0016102)5.28014288
29chromosome organization involved in meiosis (GO:0070192)5.14549512
30regulation of inclusion body assembly (GO:0090083)5.05334597
31axoneme assembly (GO:0035082)5.00257452
32meiotic nuclear division (GO:0007126)4.98148496
33pyrimidine-containing compound transmembrane transport (GO:0072531)4.96495518
34meiosis I (GO:0007127)4.95333448
35gamete generation (GO:0007276)4.92344553
36response to xenobiotic stimulus (GO:0009410)4.90176267
37cellular process involved in reproduction in multicellular organism (GO:0022412)4.89221625
38germ cell development (GO:0007281)4.83273191
39organic cation transport (GO:0015695)4.81146085
40tolerance induction (GO:0002507)4.63218786
41regulation of microtubule-based movement (GO:0060632)4.61577850
42negative regulation of T cell differentiation in thymus (GO:0033085)4.59541935
43meiotic cell cycle (GO:0051321)4.48393999
44cell projection assembly (GO:0030031)4.46591862
45one-carbon compound transport (GO:0019755)4.41035007
46protein localization to cilium (GO:0061512)4.39812128
47ethanol oxidation (GO:0006069)4.37210062
48microtubule depolymerization (GO:0007019)4.33353074
49microtubule severing (GO:0051013)4.32868538
50cell recognition (GO:0008037)4.30731072
51negative regulation of B cell mediated immunity (GO:0002713)4.25798624
52negative regulation of immunoglobulin mediated immune response (GO:0002890)4.25798624
53lung epithelium development (GO:0060428)4.19293473
54glomerular epithelial cell development (GO:0072310)4.18723893
55exogenous drug catabolic process (GO:0042738)4.16949564
56negative regulation of humoral immune response (GO:0002921)4.15990272
57calcium ion-dependent exocytosis (GO:0017156)4.14452002
58intraciliary transport (GO:0042073)4.12389264
59terpenoid biosynthetic process (GO:0016114)4.07568236
60regulation of interleukin-5 production (GO:0032674)4.05543613
61spermatid nucleus differentiation (GO:0007289)4.05342667
62regulation of germinal center formation (GO:0002634)4.05224390
63seminiferous tubule development (GO:0072520)3.99493906
64interferon-gamma secretion (GO:0072643)3.98845459
65nucleoside diphosphate phosphorylation (GO:0006165)3.93671964
66retinoic acid metabolic process (GO:0042573)3.93109748
67lateral ventricle development (GO:0021670)3.91727006
68GTP biosynthetic process (GO:0006183)3.88346822
69multicellular organismal reproductive process (GO:0048609)3.87023714
70left/right pattern formation (GO:0060972)3.83013921
71establishment of apical/basal cell polarity (GO:0035089)3.75236810
72microtubule-based movement (GO:0007018)3.72288025
73regulation of interleukin-13 production (GO:0032656)3.65994714
74gene silencing by RNA (GO:0031047)3.59307750
75cytoplasmic microtubule organization (GO:0031122)3.58295702
76protein polyglutamylation (GO:0018095)3.55705901
77left/right axis specification (GO:0070986)3.50799683
78positive regulation of tolerance induction (GO:0002645)3.48297211
79cilium organization (GO:0044782)3.47935235
80aldehyde catabolic process (GO:0046185)3.45503053
81glutathione derivative biosynthetic process (GO:1901687)3.43625605
82glutathione derivative metabolic process (GO:1901685)3.43625605
83drug catabolic process (GO:0042737)3.43563368
84microtubule polymerization or depolymerization (GO:0031109)3.41337509
85UTP biosynthetic process (GO:0006228)3.40199059
86synapsis (GO:0007129)3.39925401
87negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.39200609
88genitalia morphogenesis (GO:0035112)3.37959912
89determination of left/right symmetry (GO:0007368)3.33407200
90monoubiquitinated protein deubiquitination (GO:0035520)3.32052454
91establishment of monopolar cell polarity (GO:0061162)3.31329326
92establishment or maintenance of monopolar cell polarity (GO:0061339)3.31329326
93cilium assembly (GO:0042384)3.28563878
94carnitine transmembrane transport (GO:1902603)3.23699367
95amino-acid betaine transport (GO:0015838)3.21518323
96carnitine transport (GO:0015879)3.21518323
97determination of bilateral symmetry (GO:0009855)3.19239054
98desmosome organization (GO:0002934)3.17377970
99primary alcohol metabolic process (GO:0034308)3.14240021
100cellular component assembly involved in morphogenesis (GO:0010927)3.14183541
101specification of symmetry (GO:0009799)3.13673512
102chaperone-mediated protein complex assembly (GO:0051131)3.12111705
103multicellular organismal development (GO:0007275)3.11520553
104alditol metabolic process (GO:0019400)3.11454090
105retinal rod cell development (GO:0046548)3.10592535
106smoothened signaling pathway (GO:0007224)3.05468976
107UTP metabolic process (GO:0046051)3.04842829
108retinol metabolic process (GO:0042572)3.03177350
109regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.02754582
110cilium morphogenesis (GO:0060271)3.02630980
111meiotic cell cycle process (GO:1903046)3.00662863
112establishment of tissue polarity (GO:0007164)3.00543488
113establishment of planar polarity (GO:0001736)3.00543488
114negative regulation of organelle assembly (GO:1902116)3.00367086
115protein refolding (GO:0042026)2.94528721
116centriole replication (GO:0007099)2.92226662
117regulation of centriole replication (GO:0046599)2.90713696
118O-glycan processing (GO:0016266)2.89455009
119regulation of meiosis I (GO:0060631)2.89053913
120microtubule-based process (GO:0007017)2.87862426
121glycerol metabolic process (GO:0006071)2.86917461
122organelle assembly (GO:0070925)2.86875451
123centriole assembly (GO:0098534)2.83120608
124photoreceptor cell maintenance (GO:0045494)2.72682391
125regulation of autophagic vacuole assembly (GO:2000785)2.71757604
126carnitine metabolic process (GO:0009437)2.69814699
127microtubule bundle formation (GO:0001578)2.67729069
128hydrogen peroxide biosynthetic process (GO:0050665)2.66941167
129regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.66911971
130positive regulation of smoothened signaling pathway (GO:0045880)2.65678410
131lactate metabolic process (GO:0006089)2.64956208
132guanosine-containing compound biosynthetic process (GO:1901070)2.64847982
133negative regulation of DNA repair (GO:0045738)2.63473723
134retinal cone cell development (GO:0046549)2.62612610
135lateral sprouting from an epithelium (GO:0060601)2.61486997
136nonmotile primary cilium assembly (GO:0035058)2.61144649
137establishment of skin barrier (GO:0061436)2.60171057
138intra-S DNA damage checkpoint (GO:0031573)2.58166738
139glycerol ether metabolic process (GO:0006662)2.57057047
140phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.55785501
141sex differentiation (GO:0007548)2.53634497
142regulation of spindle checkpoint (GO:0090231)2.52100260
143hydrogen peroxide catabolic process (GO:0042744)2.51054175
144hemidesmosome assembly (GO:0031581)2.49706343
145regulation of protein polyubiquitination (GO:1902914)2.49158391
146nucleotide phosphorylation (GO:0046939)2.47443471
147excretion (GO:0007588)2.47256177
148regulation of tolerance induction (GO:0002643)2.45237797
149nucleoside diphosphate metabolic process (GO:0009132)2.45030958
150multicellular organismal water homeostasis (GO:0050891)2.44838038
151CTP biosynthetic process (GO:0006241)2.44716866
152CTP metabolic process (GO:0046036)2.44716866
153regulation of microtubule depolymerization (GO:0031114)2.39688983
154ether metabolic process (GO:0018904)2.39106286
155regulation of vacuole organization (GO:0044088)2.38551465
156pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.36073383
157nucleus organization (GO:0006997)2.35310708
158reactive oxygen species biosynthetic process (GO:1903409)2.34615712
159phosphatidylcholine biosynthetic process (GO:0006656)2.34205641
160calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.31510427
161heart looping (GO:0001947)2.26807886
162oligosaccharide biosynthetic process (GO:0009312)2.26641342
163cilium or flagellum-dependent cell motility (GO:0001539)16.7639726
164fusion of sperm to egg plasma membrane (GO:0007342)12.9433218
165axonemal dynein complex assembly (GO:0070286)12.0830097
166multicellular organism reproduction (GO:0032504)10.9908604
167sperm motility (GO:0030317)10.9504328
168acrosome assembly (GO:0001675)10.6847428
169sperm-egg recognition (GO:0035036)10.3803329
170epithelial cilium movement (GO:0003351)10.3184413
171cilium movement (GO:0003341)10.2035735

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.75699361
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.74692412
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.13876336
4EZH2_22144423_ChIP-Seq_EOC_Human4.44553405
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.99073251
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.81997852
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.44064607
8FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.36277783
9STAT6_21828071_ChIP-Seq_BEAS2B_Human3.33736479
10DROSHA_22980978_ChIP-Seq_HELA_Human2.86298594
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.57623191
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.34102326
13VDR_22108803_ChIP-Seq_LS180_Human2.32406957
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.23061782
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.11111207
16PIAS1_25552417_ChIP-Seq_VCAP_Human2.03845491
17PCGF2_27294783_Chip-Seq_ESCs_Mouse2.03229792
18ZNF274_21170338_ChIP-Seq_K562_Hela1.86726431
19STAT1_20625510_ChIP-Seq_HELA_Human1.84761073
20GATA1_26923725_Chip-Seq_HPCs_Mouse1.84336551
21PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.82898197
22FOXM1_26456572_ChIP-Seq_MCF-7_Human1.80777550
23CBX2_27304074_Chip-Seq_ESCs_Mouse1.77698135
24FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.76369425
25AHR_22903824_ChIP-Seq_MCF-7_Human1.74321739
26EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.72729919
27ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.71442030
28ESR1_20079471_ChIP-ChIP_T-47D_Human1.69791159
29NR3C1_21868756_ChIP-Seq_MCF10A_Human1.69275918
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.67053811
31TP63_23658742_ChIP-Seq_EP156T_Human1.62743810
32RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.61035422
33PCGF2_27294783_Chip-Seq_NPCs_Mouse1.60940346
34TRIM28_21343339_ChIP-Seq_HEK293_Human1.60868479
35ETV1_20927104_ChIP-Seq_GIST48_Human1.60488515
36KAP1_22055183_ChIP-Seq_ESCs_Mouse1.60002203
37TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.59683206
38ELK4_26923725_Chip-Seq_MESODERM_Mouse1.58337779
39CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.56398707
40KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.55764899
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55751480
42AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.55723899
43PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.53974692
44HNFA_21074721_ChIP-Seq_CACO-2_Human1.52153361
45CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.50608719
46ARNT_22903824_ChIP-Seq_MCF-7_Human1.50572167
47TAL1_26923725_Chip-Seq_HPCs_Mouse1.50466776
48CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.50190600
49SMRT_27268052_Chip-Seq_Bcells_Human1.50162194
50NFE2_27457419_Chip-Seq_LIVER_Mouse1.47322221
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46443187
52WDR5_24793694_ChIP-Seq_LNCAP_Human1.43358038
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.42566180
54RBPJ_21746931_ChIP-Seq_IB4_Human1.42466958
55CBP_20019798_ChIP-Seq_JUKART_Human1.42186558
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42186558
57STAT1_17558387_ChIP-Seq_HELA_Human1.41535338
58TP53_18474530_ChIP-ChIP_U2OS_Human1.41090262
59RNF2_27304074_Chip-Seq_NSC_Mouse1.40253172
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40009055
61AR_20517297_ChIP-Seq_VCAP_Human1.39877579
62TDRD3_21172665_ChIP-Seq_MCF-7_Human1.38552987
63GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.38323063
64GATA6_21074721_ChIP-Seq_CACO-2_Human1.36820163
65GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.35047404
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.34825447
67SMAD4_21799915_ChIP-Seq_A2780_Human1.33321025
68NFYA_21822215_ChIP-Seq_K562_Human1.32412418
69STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.32386345
70TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31880806
71FOXA1_25552417_ChIP-Seq_VCAP_Human1.31748513
72GATA3_21867929_ChIP-Seq_TH1_Mouse1.29800850
73CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28620618
74TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.28413302
75MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.26425345
76TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.26187469
77TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.25880083
78ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25391515
79GATA3_21867929_ChIP-Seq_CD8_Mouse1.25147574
80KDM2B_26808549_Chip-Seq_REH_Human1.25079490
81CBX2_22325352_ChIP-Seq_293T-Rex_Human1.24603480
82SOX2_27498859_Chip-Seq_STOMACH_Mouse1.24504487
83CEBPB_22108803_ChIP-Seq_LS180_Human1.23345087
84ELF1_20517297_ChIP-Seq_JURKAT_Human1.21684539
85RUNX1_27514584_Chip-Seq_MCF-7_Human1.21259793
86SMC4_20622854_ChIP-Seq_HELA_Human1.20756153
87TCF4_22108803_ChIP-Seq_LS180_Human1.17806878
88CRX_20693478_ChIP-Seq_RETINA_Mouse1.16892290
89GATA4_25053715_ChIP-Seq_YYC3_Human1.16056528
90FLI1_21867929_ChIP-Seq_TH2_Mouse1.15679686
91CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15366572
92SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.14213798
93CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12946572
94KLF5_25053715_ChIP-Seq_YYC3_Human1.12812737
95E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.12798361
96EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12022649
97NANOG_18555785_Chip-Seq_ESCs_Mouse1.11860166
98SOX2_20726797_ChIP-Seq_SW620_Human1.11736265
99BCAT_22108803_ChIP-Seq_LS180_Human1.11492303
100ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10559476
101SOX2_22085726_ChIP-Seq_NPCs_Mouse1.10313773
102PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.10175584
103ESR1_21235772_ChIP-Seq_MCF-7_Human1.09958076
104CBP_21632823_ChIP-Seq_H3396_Human1.09624661
105STAT3_23295773_ChIP-Seq_U87_Human1.09165997
106CTCF_20526341_ChIP-Seq_ESCs_Human1.09158416
107TP63_22573176_ChIP-Seq_HFKS_Human1.09118440
108EZH2_27294783_Chip-Seq_NPCs_Mouse1.08927570
109OCT4_18555785_Chip-Seq_ESCs_Mouse1.08851494
110CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08795947
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08616349
112YY1_22570637_ChIP-Seq_MALME-3M_Human1.08033579
113FOXA1_25329375_ChIP-Seq_VCAP_Human1.08003969
114FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08003969
115FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07543669
116CDX2_22108803_ChIP-Seq_LS180_Human1.07191301
117MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07032525
118MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06930813
119LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.06641637
120FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.06307031
121SMAD3_21741376_ChIP-Seq_EPCs_Human1.06173003
122SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.05943501
123NCOR_22424771_ChIP-Seq_293T_Human1.05785996
124CTNNB1_20460455_ChIP-Seq_HCT116_Human1.05340195
125P300_27268052_Chip-Seq_Bcells_Human1.04753338
126SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04225686
127P53_21459846_ChIP-Seq_SAOS-2_Human1.03681060
128EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03426040
129EGR1_23403033_ChIP-Seq_LIVER_Mouse1.03260281
130GATA3_24758297_ChIP-Seq_MCF-7_Human1.02940110
131P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02801329
132FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.02794232
133SMAD3_21741376_ChIP-Seq_HESCs_Human1.02300158
134TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01537053
135FUS_26573619_Chip-Seq_HEK293_Human1.01494039
136POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01143659
137TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01143659
138RAD21_21589869_ChIP-Seq_MESCs_Mouse1.01070376
139SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.00411582
140MYC_19829295_ChIP-Seq_ESCs_Human1.00302804
141EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00154617
142FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98845831
143SOX2_21211035_ChIP-Seq_LN229_Human0.98829473
144GF1_26923725_Chip-Seq_HPCs_Mouse0.98820043
145CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98601265
146TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98566528
147SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.97931854
148P53_22387025_ChIP-Seq_ESCs_Mouse0.97778896
149KLF4_18555785_Chip-Seq_ESCs_Mouse0.96579945
150CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96238160
151RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94796745
152ESRRB_18555785_Chip-Seq_ESCs_Mouse0.94381659
153P300_18555785_Chip-Seq_ESCs_Mouse0.94139865
154OCT4_21477851_ChIP-Seq_ESCs_Mouse0.93962636
155CMYC_18555785_Chip-Seq_ESCs_Mouse0.93600790
156TBL1_22424771_ChIP-Seq_293T_Human0.90971490
157SOX9_24532713_ChIP-Seq_HFSC_Mouse0.90872995
158RUNX1_26923725_Chip-Seq_HPCs_Mouse0.90569607
159STAT3_18555785_Chip-Seq_ESCs_Mouse0.89803446
160REST_21632747_ChIP-Seq_MESCs_Mouse0.89570063
161PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.89556751
162RUNX1_27457419_Chip-Seq_LIVER_Mouse0.88024885
163SUZ12_18555785_Chip-Seq_ESCs_Mouse0.87595934
164NFYB_21822215_ChIP-Seq_K562_Human0.86456338
165NANOG_20526341_ChIP-Seq_ESCs_Human0.86328599
166TAF15_26573619_Chip-Seq_HEK293_Human0.85728852
167STAT3_18555785_ChIP-Seq_MESCs_Mouse0.84623773
168PHF8_20622853_ChIP-Seq_HELA_Human0.83691003
169LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.83216358
170ERG_20517297_ChIP-Seq_VCAP_Human0.83215466
171GF1B_26923725_Chip-Seq_HPCs_Mouse0.83187528
172EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.82245270
173PU1_27457419_Chip-Seq_LIVER_Mouse0.82099816
174SMAD4_21741376_ChIP-Seq_EPCs_Human0.81451612
175SOX2_18555785_Chip-Seq_ESCs_Mouse0.81416329
176CTCF_18555785_Chip-Seq_ESCs_Mouse0.81067303

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok7.05662436
2MP0003698_abnormal_male_reproductive5.22986543
3MP0001929_abnormal_gametogenesis4.77701022
4MP0008877_abnormal_DNA_methylation4.54906143
5MP0002796_impaired_skin_barrier3.76940142
6MP0002653_abnormal_ependyma_morphology3.75307432
7MP0004043_abnormal_pH_regulation3.66614396
8MP0004133_heterotaxia3.55631766
9MP0009780_abnormal_chondrocyte_physiolo3.52553489
10MP0002210_abnormal_sex_determination3.39385607
11MP0004381_abnormal_hair_follicle3.27129441
12MP0002277_abnormal_respiratory_mucosa3.24814875
13MP0008789_abnormal_olfactory_epithelium3.14003416
14MP0001145_abnormal_male_reproductive2.75534283
15MP0002161_abnormal_fertility/fecundity2.73632075
16MP0000653_abnormal_sex_gland2.48480766
17MP0005623_abnormal_meninges_morphology2.29055808
18MP0003941_abnormal_skin_development2.16989079
19MP0003136_yellow_coat_color2.11342668
20MP0005501_abnormal_skin_physiology2.01391873
21MP0005410_abnormal_fertilization13.0659364
22MP0005394_taste/olfaction_phenotype1.97902177
23MP0005499_abnormal_olfactory_system1.97902177
24MP0002168_other_aberrant_phenotype1.81021011
25MP0001984_abnormal_olfaction1.79935055
26MP0000647_abnormal_sebaceous_gland1.79746321
27MP0002282_abnormal_trachea_morphology1.76348506
28MP0003656_abnormal_erythrocyte_physiolo1.75173696
29MP0002160_abnormal_reproductive_system1.68017478
30MP0002909_abnormal_adrenal_gland1.60174102
31MP0001216_abnormal_epidermal_layer1.55259152
32MP0002254_reproductive_system_inflammat1.54302312
33MP0000383_abnormal_hair_follicle1.54127583
34MP0003806_abnormal_nucleotide_metabolis1.52502332
35MP0009046_muscle_twitch1.50858736
36MP0005395_other_phenotype1.49508215
37MP0003011_delayed_dark_adaptation1.48774455
38MP0005647_abnormal_sex_gland1.48746994
39MP0005083_abnormal_biliary_tract1.47236922
40MP0008057_abnormal_DNA_replication1.47059836
41MP0001851_eye_inflammation1.44974094
42MP0000427_abnormal_hair_cycle1.44939024
43MP0002060_abnormal_skin_morphology1.44540255
44MP0008995_early_reproductive_senescence1.34749527
45MP0005275_abnormal_skin_tensile1.29147055
46MP0002009_preneoplasia1.27990753
47MP0010771_integument_phenotype1.26889421
48MP0005670_abnormal_white_adipose1.24041935
49MP0002139_abnormal_hepatobiliary_system1.23200957
50MP0005365_abnormal_bile_salt1.22781055
51MP0002734_abnormal_mechanical_nocicepti1.16287431
52MP0010678_abnormal_skin_adnexa1.15805172
53MP0005085_abnormal_gallbladder_physiolo1.13980571
54MP0003786_premature_aging1.11432399
55MP0010234_abnormal_vibrissa_follicle1.10961580
56MP0000465_gastrointestinal_hemorrhage1.09337588
57MP0001485_abnormal_pinna_reflex1.08655473
58MP0005165_increased_susceptibility_to1.07584503
59MP0006036_abnormal_mitochondrial_physio1.07156666
60MP0001765_abnormal_ion_homeostasis1.06741491
61MP0005389_reproductive_system_phenotype1.05635036
62MP0003718_maternal_effect1.05584090
63MP0005451_abnormal_body_composition1.03634699
64MP0002876_abnormal_thyroid_physiology1.02633215
65MP0010155_abnormal_intestine_physiology1.00926452
66MP0005220_abnormal_exocrine_pancreas0.99168092
67MP0000678_abnormal_parathyroid_gland0.97456358
68MP0009643_abnormal_urine_homeostasis0.96317677
69MP0002132_abnormal_respiratory_system0.94461942
70MP0010030_abnormal_orbit_morphology0.93933649
71MP0005408_hypopigmentation0.93921493
72MP0003453_abnormal_keratinocyte_physiol0.93485590
73MP0000377_abnormal_hair_follicle0.91850838
74MP0008872_abnormal_physiological_respon0.90368241
75MP0002234_abnormal_pharynx_morphology0.90022481
76MP0009379_abnormal_foot_pigmentation0.88854623
77MP0003950_abnormal_plasma_membrane0.87016908
78MP0000467_abnormal_esophagus_morphology0.83154971
79MP0009765_abnormal_xenobiotic_induced0.82199514
80MP0008058_abnormal_DNA_repair0.81378427
81MP0002638_abnormal_pupillary_reflex0.80009258
82MP0002136_abnormal_kidney_physiology0.79337821
83MP0002735_abnormal_chemical_nociception0.79083086
84MP0005646_abnormal_pituitary_gland0.77774541
85MP0003195_calcinosis0.77632257
86MP0005248_abnormal_Harderian_gland0.73766719
87MP0010094_abnormal_chromosome_stability0.72312106
88MP0004947_skin_inflammation0.72303586
89MP0005645_abnormal_hypothalamus_physiol0.72256309
90MP0003252_abnormal_bile_duct0.71063030
91MP0000566_synostosis0.70557750
92MP0002249_abnormal_larynx_morphology0.69321170
93MP0002098_abnormal_vibrissa_morphology0.68347959
94MP0008007_abnormal_cellular_replicative0.67809784
95MP0004883_abnormal_blood_vessel0.67615346
96MP0009931_abnormal_skin_appearance0.67563267
97MP0000026_abnormal_inner_ear0.66993231
98MP0004019_abnormal_vitamin_homeostasis0.65594758
99MP0009763_increased_sensitivity_to0.64991075
100MP0001293_anophthalmia0.64493792
101MP0005164_abnormal_response_to0.63963583
102MP0001191_abnormal_skin_condition0.62373930
103MP0002163_abnormal_gland_morphology0.62321110
104MP0001340_abnormal_eyelid_morphology0.62308690
105MP0008004_abnormal_stomach_pH0.61872784
106MP0001324_abnormal_eye_pigmentation0.61716408
107MP0001919_abnormal_reproductive_system0.60941736
108MP0008873_increased_physiological_sensi0.60075946
109MP0000681_abnormal_thyroid_gland0.59318327
110MP0001905_abnormal_dopamine_level0.58522135
111MP0003866_abnormal_defecation0.57843123
112MP0001944_abnormal_pancreas_morphology0.56605113
113MP0001666_abnormal_nutrient_absorption0.56163816
114MP0002229_neurodegeneration0.54128846
115MP0001963_abnormal_hearing_physiology0.53579683
116MP0005636_abnormal_mineral_homeostasis0.52232944
117MP0003699_abnormal_female_reproductive0.52092116
118MP0005195_abnormal_posterior_eye0.52058920
119MP0005310_abnormal_salivary_gland0.51865349
120MP0002822_catalepsy0.51701168
121MP0003186_abnormal_redox_activity0.49526758
122MP0001545_abnormal_hematopoietic_system0.48736857
123MP0005397_hematopoietic_system_phenotyp0.48736857
124MP0003646_muscle_fatigue0.47730052
125MP0001270_distended_abdomen0.47402712
126MP0003315_abnormal_perineum_morphology0.46880140
127MP0005387_immune_system_phenotype0.46378088
128MP0001790_abnormal_immune_system0.46378088
129MP0002102_abnormal_ear_morphology0.45868550
130MP0000579_abnormal_nail_morphology0.45421006
131MP0001849_ear_inflammation0.44181009
132MP0002135_abnormal_kidney_morphology0.44125922
133MP0001119_abnormal_female_reproductive0.43858808
134MP0003937_abnormal_limbs/digits/tail_de0.43804791
135MP0000631_abnormal_neuroendocrine_gland0.43631654
136MP0000367_abnormal_coat/_hair0.43613575
137MP0005377_hearing/vestibular/ear_phenot0.41873337
138MP0003878_abnormal_ear_physiology0.41873337
139MP0001346_abnormal_lacrimal_gland0.41868259
140MP0001727_abnormal_embryo_implantation0.41554196
141MP0001970_abnormal_pain_threshold0.41386571
142MP0005187_abnormal_penis_morphology0.39688240
143MP0004233_abnormal_muscle_weight0.38816846
144MP0005391_vision/eye_phenotype0.38519699
145MP0005409_darkened_coat_color0.37983763
146MP0005551_abnormal_eye_electrophysiolog0.37569037
147MP0001243_abnormal_dermal_layer0.36032404
148MP0002928_abnormal_bile_duct0.35554073
149MP0000762_abnormal_tongue_morphology0.34369731
150MP0000372_irregular_coat_pigmentation0.34142497
151MP0002092_abnormal_eye_morphology0.34096140
152MP0005253_abnormal_eye_physiology0.34031053
153MP0006072_abnormal_retinal_apoptosis0.31533349
154MP0005388_respiratory_system_phenotype0.31336108
155MP0002133_abnormal_respiratory_system0.31336108
156MP0000432_abnormal_head_morphology0.30957070
157MP0010352_gastrointestinal_tract_polyps0.29895209
158MP0009250_abnormal_appendicular_skeleto0.26794432
159MP0003936_abnormal_reproductive_system0.26129187
160MP0001784_abnormal_fluid_regulation0.26021784
161MP0002233_abnormal_nose_morphology0.25866425
162MP0002405_respiratory_system_inflammati0.25014214
163MP0000537_abnormal_urethra_morphology0.24748130
164MP0004782_abnormal_surfactant_physiolog0.23894595
165MP0005666_abnormal_adipose_tissue0.23863392
166MP0000358_abnormal_cell_content/0.23830703
167MP0003329_amyloid_beta_deposits0.22868541

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)8.95334307
2Abnormal respiratory motile cilium morphology (HP:0005938)8.95334307
3Abnormal ciliary motility (HP:0012262)8.63797009
4Rhinitis (HP:0012384)8.63688608
5Chronic bronchitis (HP:0004469)7.46759323
6Nasal polyposis (HP:0100582)6.21687790
7Infertility (HP:0000789)5.62928259
8Abnormality of the nasal mucosa (HP:0000433)5.09197918
9Bronchiectasis (HP:0002110)4.99258745
10Bronchitis (HP:0012387)4.46551288
11Nephronophthisis (HP:0000090)3.98662839
12Recurrent sinusitis (HP:0011108)3.41851200
13Pancreatic cysts (HP:0001737)3.22014690
14Male infertility (HP:0003251)3.21283328
15Recurrent otitis media (HP:0000403)3.15307229
16Abnormality of the renal medulla (HP:0100957)3.04654549
17Chronic otitis media (HP:0000389)2.97289230
18Chronic hepatic failure (HP:0100626)2.88780053
19Gonadotropin excess (HP:0000837)2.75078785
20Atelectasis (HP:0100750)2.74531849
21Hyperactive renin-angiotensin system (HP:0000841)2.62354036
22Abnormal spermatogenesis (HP:0008669)2.59172755
23Abnormality of midbrain morphology (HP:0002418)2.58130559
24Molar tooth sign on MRI (HP:0002419)2.58130559
25Tubulointerstitial nephritis (HP:0001970)2.56196599
26Medial flaring of the eyebrow (HP:0010747)2.55238958
27Recurrent bronchitis (HP:0002837)2.46412598
28Abnormality of permanent molar morphology (HP:0011071)2.46028367
29Abnormality of the dental root (HP:0006486)2.46028367
30Taurodontia (HP:0000679)2.46028367
31Tubular atrophy (HP:0000092)2.43489608
32Chronic sinusitis (HP:0011109)2.40416576
33Abnormality of the lower motor neuron (HP:0002366)2.33739796
34Fibular hypoplasia (HP:0003038)2.29895545
35Abnormality of molar morphology (HP:0011070)2.28967164
36Abnormality of molar (HP:0011077)2.28967164
37Azoospermia (HP:0000027)2.22863259
38Abnormality of the dental pulp (HP:0006479)2.19494074
39Supernumerary spleens (HP:0009799)2.18990118
40Microglossia (HP:0000171)2.16439780
41Median cleft lip (HP:0000161)2.14244020
42Postaxial foot polydactyly (HP:0001830)2.12016502
43Anencephaly (HP:0002323)2.09558989
44Tubulointerstitial abnormality (HP:0001969)2.08300825
45Pancreatic fibrosis (HP:0100732)2.08198356
46Male pseudohermaphroditism (HP:0000037)2.07550733
47Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.8231485
48Absent/shortened dynein arms (HP:0200106)11.5805282
49Dynein arm defect of respiratory motile cilia (HP:0012255)11.5805282
50Abnormal respiratory motile cilium physiology (HP:0012261)10.1991700
51Facial cleft (HP:0002006)1.98520779
52Congenital hepatic fibrosis (HP:0002612)1.95333740
53Amyotrophic lateral sclerosis (HP:0007354)1.95325976
54Renal dysplasia (HP:0000110)1.93691736
55Bell-shaped thorax (HP:0001591)1.93266688
56Sclerocornea (HP:0000647)1.88268049
57Furrowed tongue (HP:0000221)1.87848927
58Absent rod-and cone-mediated responses on ERG (HP:0007688)1.85409519
59Impaired proprioception (HP:0010831)1.80617422
6011 pairs of ribs (HP:0000878)1.79332754
61Aplasia/Hypoplasia of the tongue (HP:0010295)1.77092113
62Stage 5 chronic kidney disease (HP:0003774)1.77068621
63Abnormality of dentin (HP:0010299)1.76407676
64Aplasia/Hypoplasia of the spleen (HP:0010451)1.67301538
65Asplenia (HP:0001746)1.67151274
66Congenital primary aphakia (HP:0007707)1.67123946
67True hermaphroditism (HP:0010459)1.65665442
68Decreased circulating renin level (HP:0003351)1.65639427
69Renal salt wasting (HP:0000127)1.65294916
70Gait imbalance (HP:0002141)1.64830353
71Impulsivity (HP:0100710)1.64651021
72Abnormality of cells of the erythroid lineage (HP:0012130)1.64629780
73Oculomotor apraxia (HP:0000657)1.63505155
74Tubulointerstitial fibrosis (HP:0005576)1.62101630
75Short ribs (HP:0000773)1.61294645
76Hypoplasia of dental enamel (HP:0006297)1.60420324
77Fragile nails (HP:0001808)1.59841926
78Hyporeflexia of lower limbs (HP:0002600)1.59341862
79Postaxial hand polydactyly (HP:0001162)1.59322899
80Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.56891702
81Genital tract atresia (HP:0001827)1.55909804
82Hypodontia (HP:0000668)1.54626588
83Hypotrichosis (HP:0001006)1.51469823
84Vaginal atresia (HP:0000148)1.50007001
85Abnormality of the renal cortex (HP:0011035)1.49254422
86Milia (HP:0001056)1.48316585
87Ridged nail (HP:0001807)1.46754715
88Plantar hyperkeratosis (HP:0007556)1.46099793
89Absent eyebrow (HP:0002223)1.45076825
90Nephrogenic diabetes insipidus (HP:0009806)1.43380814
91Abnormal biliary tract physiology (HP:0012439)1.43189537
92Bile duct proliferation (HP:0001408)1.43189537
93Abnormal number of erythroid precursors (HP:0012131)1.43011729
94Hypoplasia of the capital femoral epiphysis (HP:0003090)1.41404907
95Aplasia/Hypoplasia of the fibula (HP:0006492)1.41296101
96Hyperkalemia (HP:0002153)1.41049600
97Polydipsia (HP:0001959)1.39722741
98Abnormal drinking behavior (HP:0030082)1.39722741
99Onycholysis (HP:0001806)1.38974527
100Concave nail (HP:0001598)1.38162760
101Abnormal rod and cone electroretinograms (HP:0008323)1.38068641
102Absent frontal sinuses (HP:0002688)1.36295238
103Cystic liver disease (HP:0006706)1.35573890
104Hyperaldosteronism (HP:0000859)1.35045578
105J-shaped sella turcica (HP:0002680)1.32768762
106Lip pit (HP:0100267)1.31614344
107Occipital encephalocele (HP:0002085)1.30766973
108Poor coordination (HP:0002370)1.29909176
109Decreased central vision (HP:0007663)1.29540581
110Nephropathy (HP:0000112)1.28971079
111Congenital ichthyosiform erythroderma (HP:0007431)1.28752949
112Short nail (HP:0001799)1.26894564
113Abnormality of renin-angiotensin system (HP:0000847)1.25135528
114Spastic tetraparesis (HP:0001285)1.21759862
115Degeneration of anterior horn cells (HP:0002398)1.21484076
116Abnormality of the anterior horn cell (HP:0006802)1.21484076
117Hypokalemic alkalosis (HP:0001949)1.21374570
118Short thorax (HP:0010306)1.20732881
119Glucose intolerance (HP:0000833)1.20709519
120Abnormality of saccadic eye movements (HP:0000570)1.19190102
121Aplasia/Hypoplasia of the lens (HP:0008063)1.18691683
122Breast carcinoma (HP:0003002)1.18094019
123Preaxial hand polydactyly (HP:0001177)1.17886161
124Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.17402145
125Cone-rod dystrophy (HP:0000548)1.16877785
126Abnormality of chloride homeostasis (HP:0011422)1.16740953
127Bifid scrotum (HP:0000048)1.10896761
128Retinitis pigmentosa (HP:0000510)1.10647816
129Abnormality of macular pigmentation (HP:0008002)1.01689393
130Abnormality of monocarboxylic acid metabolism (HP:0010996)1.00466092
131Narrow forehead (HP:0000341)0.99866190
132Aganglionic megacolon (HP:0002251)0.97360458
133Abnormality of the frontal sinuses (HP:0002687)0.96657502
134Hyponatremia (HP:0002902)0.96418916
135Prominent nasal bridge (HP:0000426)0.95120420
136Abnormality of the distal phalanges of the toes (HP:0010182)0.94869478
137Hand muscle atrophy (HP:0009130)0.94496179

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.72455827
2PDK48.72455827
3PDK25.60299952
4TESK14.46567409
5EPHA24.29605522
6PNCK2.93235112
7PRKD32.81003648
8WNK42.53491060
9MAPK152.49762430
10STK392.46328145
11ICK2.21985384
12PTK2B2.21255863
13STK161.65493670
14TLK11.57891379
15NEK21.45930426
16FRK1.45269210
17MAP4K21.40943394
18MST1R1.40577521
19MAPKAPK31.39392281
20MAP3K41.36273356
21WEE11.30050772
22MAP2K71.20687163
23INSRR1.18376974
24CSK1.12458800
25STK381.05018425
26MAP3K31.00225276
27MAPKAPK50.99478958
28DYRK1B0.98701237
29WNK30.96377332
30BMPR1B0.95408538
31WNK10.94757637
32STK30.93950939
33MST40.90442056
34MAP3K120.88759502
35TBK10.88502802
36PRKCI0.85863230
37PASK0.82220027
38TSSK60.79077172
39SMG10.78307872
40STK240.73396189
41OXSR10.72205892
42DYRK30.72193968
43STK100.71901850
44PDK10.71516370
45TESK20.69662484
46STK38L0.69048941
47TYRO30.66855611
48EPHB10.66433241
49CCNB10.65448312
50ADRBK20.65129723
51EIF2AK30.64223809
52ERBB20.63702065
53BRSK20.61895708
54MAP3K70.61288944
55LMTK20.60404297
56TTK0.60372905
57FER0.58627979
58EEF2K0.58323983
59TRIM280.56445717
60IRAK10.52403017
61EPHA30.52051362
62MAP2K60.51723415
63RPS6KB20.44936337
64CHEK20.44082027
65CDK30.44034866
66CDC70.43883088
67PLK40.43722128
68NTRK20.43464852
69ZAK0.40225820
70PRKCD0.40093914
71GRK10.39620362
72CHEK10.37466208
73CAMK2G0.35017961
74CSNK1G20.34806910
75GRK70.34678108
76AURKA0.34668896
77LIMK10.33873064
78MARK20.33817363
79PAK40.33475987
80BCKDK0.32481467
81MAP3K20.32013290
82MAPK130.31449126
83AKT20.30959441
84GRK50.30699475
85ABL10.30304111
86PBK0.30276043
87ATM0.29898278
88MET0.29462450
89PIM20.28932389
90MAP2K40.28706737
91TRPM70.28532392
92PRKACA0.28399340
93CDK190.28199116
94CAMKK10.26963846
95LRRK20.26699128
96EIF2AK10.25196123
97ADRBK10.24929328
98MYLK0.24460583
99EGFR0.24396025
100PRKCE0.23987460
101MAP2K20.23984822
102ATR0.23906677
103PRKCG0.22956092
104CAMK2A0.22633618
105PRKAA20.22025346
106TAOK10.21985935
107BRSK10.21867932
108IGF1R0.21777423
109PAK10.21722153
110CDK90.21505003
111MUSK0.21463045
112CHUK0.20824129
113ROCK10.20795801
114STK110.20328216
115RIPK40.20090304
116NEK90.19926839
117LATS10.19463615
118CSNK1A1L0.18126221
119TXK0.18004156
120PLK10.16722282
121BMPR20.16131826
122VRK10.15666793
123ERBB30.15621238
124TEC0.15262282
125GRK60.14943174
126CDK120.13680333
127PDPK10.12355945
128MAPKAPK20.11688460
129CSNK2A10.11264859
130PAK20.10691332
131PINK10.10479658
132MTOR0.10121795
133CSNK1D0.09806902
134CDK60.09470890
135RPS6KA10.09399908
136CSNK2A20.09388166
137LATS20.08855450
138YES10.08589379
139RPS6KB10.08494127
140NEK60.07911225
141AURKB0.07601461
142PRKCQ0.06863480
143CAMK1G0.06814796
144MAP3K10.06631237
145EIF2AK20.06507630
146FGFR20.05691107
147MOS0.04729154
148TGFBR20.04606407
149BCR0.04520760
150PRKACG0.04388844
151PRKCA0.04035487
152BRAF0.03811222
153PRKDC0.02707019
154NME10.02706518
155ILK0.02683720

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.03607522
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.47716853
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.45006064
4Tyrosine metabolism_Homo sapiens_hsa003503.42666544
5Linoleic acid metabolism_Homo sapiens_hsa005913.41058811
6Pyruvate metabolism_Homo sapiens_hsa006203.22970981
7beta-Alanine metabolism_Homo sapiens_hsa004102.98671643
8Fatty acid biosynthesis_Homo sapiens_hsa000612.78784277
9Caffeine metabolism_Homo sapiens_hsa002322.76485415
10Basal transcription factors_Homo sapiens_hsa030222.75468592
11Huntingtons disease_Homo sapiens_hsa050162.66766060
12Dorso-ventral axis formation_Homo sapiens_hsa043202.63781109
13Propanoate metabolism_Homo sapiens_hsa006402.51051148
14Pentose phosphate pathway_Homo sapiens_hsa000302.48808525
15Fanconi anemia pathway_Homo sapiens_hsa034602.37563518
16Cyanoamino acid metabolism_Homo sapiens_hsa004602.36793956
17Glucagon signaling pathway_Homo sapiens_hsa049222.27546129
18Arachidonic acid metabolism_Homo sapiens_hsa005902.01679268
19Sphingolipid metabolism_Homo sapiens_hsa006001.99352306
20Ribosome_Homo sapiens_hsa030101.93847781
21Oocyte meiosis_Homo sapiens_hsa041141.83641751
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.82355699
23Ether lipid metabolism_Homo sapiens_hsa005651.72601577
24Renin secretion_Homo sapiens_hsa049241.70915860
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.60380958
26Peroxisome_Homo sapiens_hsa041461.58677526
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.56329965
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.54075143
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.50031356
30Glycerolipid metabolism_Homo sapiens_hsa005611.45272008
31Selenocompound metabolism_Homo sapiens_hsa004501.43821979
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.41976877
33Glutathione metabolism_Homo sapiens_hsa004801.40441243
34PPAR signaling pathway_Homo sapiens_hsa033201.38592955
35Amphetamine addiction_Homo sapiens_hsa050311.36557202
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.36392188
37Mineral absorption_Homo sapiens_hsa049781.34644898
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.30754262
39Glycerophospholipid metabolism_Homo sapiens_hsa005641.29971647
40Chemical carcinogenesis_Homo sapiens_hsa052041.23514055
41ABC transporters_Homo sapiens_hsa020101.22917678
42Cardiac muscle contraction_Homo sapiens_hsa042601.22776762
43Drug metabolism - other enzymes_Homo sapiens_hsa009831.19474980
44Carbohydrate digestion and absorption_Homo sapiens_hsa049731.16478763
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.13156431
46Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.09276269
47Butanoate metabolism_Homo sapiens_hsa006501.08322530
48Fat digestion and absorption_Homo sapiens_hsa049751.06707181
49Hedgehog signaling pathway_Homo sapiens_hsa043401.06317332
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.05963224
51Pentose and glucuronate interconversions_Homo sapiens_hsa000401.04528512
52Primary bile acid biosynthesis_Homo sapiens_hsa001201.02195764
53Fructose and mannose metabolism_Homo sapiens_hsa000510.97480993
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.96291375
55Glycosaminoglycan degradation_Homo sapiens_hsa005310.96150216
56Retinol metabolism_Homo sapiens_hsa008300.95580680
57Type I diabetes mellitus_Homo sapiens_hsa049400.92914564
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.89113052
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.88787127
60Starch and sucrose metabolism_Homo sapiens_hsa005000.86466589
61RNA transport_Homo sapiens_hsa030130.85580328
62Renin-angiotensin system_Homo sapiens_hsa046140.80906834
63Tryptophan metabolism_Homo sapiens_hsa003800.80628982
64mRNA surveillance pathway_Homo sapiens_hsa030150.80442866
65Estrogen signaling pathway_Homo sapiens_hsa049150.78503241
66Allograft rejection_Homo sapiens_hsa053300.78159405
67Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77732586
68Basal cell carcinoma_Homo sapiens_hsa052170.77671626
69Purine metabolism_Homo sapiens_hsa002300.77198894
70Antigen processing and presentation_Homo sapiens_hsa046120.76326502
71Protein export_Homo sapiens_hsa030600.73241495
72Carbon metabolism_Homo sapiens_hsa012000.72306839
73Calcium signaling pathway_Homo sapiens_hsa040200.70443209
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68075938
75Circadian rhythm_Homo sapiens_hsa047100.67218476
76Autoimmune thyroid disease_Homo sapiens_hsa053200.67086920
77Pancreatic secretion_Homo sapiens_hsa049720.66562874
78Complement and coagulation cascades_Homo sapiens_hsa046100.66063115
79Asthma_Homo sapiens_hsa053100.65064512
80VEGF signaling pathway_Homo sapiens_hsa043700.64759193
81Nitrogen metabolism_Homo sapiens_hsa009100.64088039
82Graft-versus-host disease_Homo sapiens_hsa053320.63306978
83Fatty acid elongation_Homo sapiens_hsa000620.62356371
84Long-term potentiation_Homo sapiens_hsa047200.61465271
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61216551
86Intestinal immune network for IgA production_Homo sapiens_hsa046720.61014554
87Collecting duct acid secretion_Homo sapiens_hsa049660.60997041
88Histidine metabolism_Homo sapiens_hsa003400.60356928
89Arginine biosynthesis_Homo sapiens_hsa002200.59205050
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57941101
91Taste transduction_Homo sapiens_hsa047420.57508603
92Fatty acid metabolism_Homo sapiens_hsa012120.56794878
93Nucleotide excision repair_Homo sapiens_hsa034200.55267219
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.54873820
95Hematopoietic cell lineage_Homo sapiens_hsa046400.54690337
96Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.53334522
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51762596
98Fatty acid degradation_Homo sapiens_hsa000710.51109174
99Parkinsons disease_Homo sapiens_hsa050120.50106673
100Olfactory transduction_Homo sapiens_hsa047400.45608179
101Phenylalanine metabolism_Homo sapiens_hsa003600.44569372
102Endocytosis_Homo sapiens_hsa041440.43766424
103Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.43473033
104Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42589451
105Arginine and proline metabolism_Homo sapiens_hsa003300.42041955
106Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40315639
107cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40081362
108Metabolic pathways_Homo sapiens_hsa011000.39632155
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.38118330
110Legionellosis_Homo sapiens_hsa051340.37590548
111Phototransduction_Homo sapiens_hsa047440.37585685
112Nicotine addiction_Homo sapiens_hsa050330.36112178
113p53 signaling pathway_Homo sapiens_hsa041150.36050956
114Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35971318
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.34883249
116Inositol phosphate metabolism_Homo sapiens_hsa005620.34545812
117Homologous recombination_Homo sapiens_hsa034400.34040222
118RNA polymerase_Homo sapiens_hsa030200.33515352
119Ovarian steroidogenesis_Homo sapiens_hsa049130.30630057
120Oxidative phosphorylation_Homo sapiens_hsa001900.30610962
121Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29852462
122Wnt signaling pathway_Homo sapiens_hsa043100.29814235
123Gastric acid secretion_Homo sapiens_hsa049710.29727839
124Central carbon metabolism in cancer_Homo sapiens_hsa052300.29645367
125Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29393645
126Pyrimidine metabolism_Homo sapiens_hsa002400.29166628
127Alzheimers disease_Homo sapiens_hsa050100.29116232
128Tight junction_Homo sapiens_hsa045300.28620941
129Salivary secretion_Homo sapiens_hsa049700.28493137
130RNA degradation_Homo sapiens_hsa030180.28435183
131Protein digestion and absorption_Homo sapiens_hsa049740.28402998
132Regulation of autophagy_Homo sapiens_hsa041400.28086903
133Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26654390
134Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26416637
135Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.25805312
136Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24049930
137Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.22461148
138Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.21664145
139Maturity onset diabetes of the young_Homo sapiens_hsa049500.21198261
140Thyroid hormone synthesis_Homo sapiens_hsa049180.21139965
141Steroid hormone biosynthesis_Homo sapiens_hsa001400.20744311
142Rheumatoid arthritis_Homo sapiens_hsa053230.20593797
143Insulin secretion_Homo sapiens_hsa049110.20179394
144N-Glycan biosynthesis_Homo sapiens_hsa005100.19825228
145Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.19226696
146Proteasome_Homo sapiens_hsa030500.18870977
147Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.18562102
148Hepatitis C_Homo sapiens_hsa051600.18225789
149Toxoplasmosis_Homo sapiens_hsa051450.17970955
150Glutamatergic synapse_Homo sapiens_hsa047240.16153462
151Jak-STAT signaling pathway_Homo sapiens_hsa046300.13737281
152Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.13038105
153Vitamin digestion and absorption_Homo sapiens_hsa049770.11997943
154Systemic lupus erythematosus_Homo sapiens_hsa053220.11815341
155Steroid biosynthesis_Homo sapiens_hsa001000.11033396
156Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.09962193

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