CFAP58

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1binding of sperm to zona pellucida (GO:0007339)9.90635493
2epithelial cilium movement (GO:0003351)9.89189541
3reproduction (GO:0000003)9.81364169
4piRNA metabolic process (GO:0034587)9.65142246
5cilium movement (GO:0003341)9.15648174
6regulation of female gonad development (GO:2000194)8.87182568
7spermatid development (GO:0007286)8.77950803
8motile cilium assembly (GO:0044458)8.76568474
9regulation of cilium movement (GO:0003352)8.61981587
10male meiosis (GO:0007140)8.54279404
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.01937351
12single fertilization (GO:0007338)7.91763716
13negative regulation of retinoic acid receptor signaling pathway (GO:0048387)7.82530027
14synaptonemal complex organization (GO:0070193)7.43885243
15synaptonemal complex assembly (GO:0007130)7.23777085
16sperm capacitation (GO:0048240)7.12394120
17retinal cone cell development (GO:0046549)7.11281270
18regulation of retinoic acid receptor signaling pathway (GO:0048385)6.71845133
19fertilization (GO:0009566)6.67909912
20positive regulation of histone H3-K4 methylation (GO:0051571)6.13404196
21microtubule severing (GO:0051013)6.13060536
22regulation of histone H3-K9 methylation (GO:0051570)5.99952459
23spermatogenesis (GO:0007283)5.99701289
24male gamete generation (GO:0048232)5.97636002
25DNA methylation involved in gamete generation (GO:0043046)5.93353041
26female gamete generation (GO:0007292)5.82897679
27oocyte development (GO:0048599)5.69798925
28negative regulation of inclusion body assembly (GO:0090084)5.69643292
29glycine transport (GO:0015816)5.64670021
30ventricular system development (GO:0021591)5.58588445
31gamete generation (GO:0007276)5.58428381
32microtubule depolymerization (GO:0007019)5.34368115
33regulation of steroid hormone secretion (GO:2000831)5.31250673
34cellular process involved in reproduction in multicellular organism (GO:0022412)5.21092450
35male meiosis I (GO:0007141)5.20803632
36germ cell development (GO:0007281)5.08108182
37organic cation transport (GO:0015695)5.05030107
38chromosome organization involved in meiosis (GO:0070192)5.00904560
39regulation of microtubule-based movement (GO:0060632)5.00157779
40cell recognition (GO:0008037)4.96533531
41protein polyglutamylation (GO:0018095)4.93067621
42negative regulation of histone methylation (GO:0031061)4.85866615
43mitotic chromosome condensation (GO:0007076)4.83216673
44regulation of cell maturation (GO:1903429)4.79305276
45calcium ion-dependent exocytosis (GO:0017156)4.70402535
46meiotic nuclear division (GO:0007126)4.70049723
47regulation of inclusion body assembly (GO:0090083)4.61250538
48negative regulation of reproductive process (GO:2000242)4.56239011
49multicellular organismal reproductive process (GO:0048609)4.40863815
50meiotic cell cycle (GO:0051321)4.29396412
51positive regulation of gastrulation (GO:2000543)4.27875719
52pyrimidine-containing compound transmembrane transport (GO:0072531)4.27492599
53spermatid nucleus differentiation (GO:0007289)4.23432398
54phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)4.22473396
55meiosis I (GO:0007127)4.21963589
56protein kinase C signaling (GO:0070528)4.16735531
57monoubiquitinated protein deubiquitination (GO:0035520)4.14704735
58positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.08925150
59positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.08925150
60positive regulation of mitotic sister chromatid separation (GO:1901970)4.08925150
61seminiferous tubule development (GO:0072520)4.08852251
62protein localization to chromosome, centromeric region (GO:0071459)4.02620941
63mitotic metaphase plate congression (GO:0007080)4.01590523
64L-amino acid import (GO:0043092)4.00454356
65protein localization to cilium (GO:0061512)4.00188742
66positive regulation of uterine smooth muscle contraction (GO:0070474)3.96493222
67regulation of meiosis (GO:0040020)3.92183270
68left/right pattern formation (GO:0060972)3.91033548
69axoneme assembly (GO:0035082)3.88587306
70establishment of chromosome localization (GO:0051303)3.83668904
71positive regulation of humoral immune response (GO:0002922)3.80122692
72positive regulation of chromosome segregation (GO:0051984)3.77724563
73intraciliary transport (GO:0042073)3.73009199
74phosphorelay signal transduction system (GO:0000160)3.69818898
75protein localization to kinetochore (GO:0034501)3.67075617
76positive regulation of histone methylation (GO:0031062)3.66497820
77oogenesis (GO:0048477)3.65467579
78glycerol ether metabolic process (GO:0006662)3.63469343
79primitive streak formation (GO:0090009)3.60702413
80negative regulation of muscle hypertrophy (GO:0014741)3.59221422
81negative regulation of cardiac muscle hypertrophy (GO:0010614)3.58965687
82regulation of steroid hormone biosynthetic process (GO:0090030)3.58399774
83histone H3-K9 demethylation (GO:0033169)3.55823464
84positive regulation of reproductive process (GO:2000243)3.51990063
85regulation of spindle organization (GO:0090224)3.51788537
86multicellular organismal development (GO:0007275)3.48913319
87attachment of spindle microtubules to kinetochore (GO:0008608)3.48527938
88gene silencing by RNA (GO:0031047)3.48095804
89positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.46713192
90genitalia morphogenesis (GO:0035112)3.46315741
91protein K11-linked deubiquitination (GO:0035871)3.40928052
92regulation of histone H3-K4 methylation (GO:0051569)3.40585963
93cilium organization (GO:0044782)3.40443376
94hyperosmotic salinity response (GO:0042538)3.40000847
95nucleoside diphosphate phosphorylation (GO:0006165)3.38271132
96cytoplasmic microtubule organization (GO:0031122)3.35715573
97ether metabolic process (GO:0018904)3.35428993
98positive regulation of microtubule polymerization (GO:0031116)3.34988334
99metaphase plate congression (GO:0051310)3.34389841
100microtubule-based movement (GO:0007018)3.32063319
101regulation of meiotic cell cycle (GO:0051445)3.30299522
102regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.29098686
103cilium assembly (GO:0042384)3.27073367
104GTP biosynthetic process (GO:0006183)3.25617207
105cilium morphogenesis (GO:0060271)3.21981541
106CENP-A containing nucleosome assembly (GO:0034080)3.21240603
107chromosome condensation (GO:0030261)3.20951369
108positive regulation of microtubule polymerization or depolymerization (GO:0031112)3.18876046
109regulation of histone methylation (GO:0031060)3.18186189
110meiotic cell cycle process (GO:1903046)3.17418982
111cellular component assembly involved in morphogenesis (GO:0010927)3.13088705
112nucleus organization (GO:0006997)3.09724341
113translesion synthesis (GO:0019985)3.08957509
114negative regulation of organelle assembly (GO:1902116)3.08477899
115centriole assembly (GO:0098534)3.06528054
116DNA packaging (GO:0006323)3.06405542
117relaxation of smooth muscle (GO:0044557)3.05906276
118negative regulation of hormone metabolic process (GO:0032351)3.05598015
119negative regulation of hormone biosynthetic process (GO:0032353)3.05510229
120synapsis (GO:0007129)3.03120658
121protein localization to chromosome (GO:0034502)3.02928374
122cellular response to pH (GO:0071467)3.02908578
123negative regulation of execution phase of apoptosis (GO:1900118)3.01613967
124DNA alkylation (GO:0006305)3.01537410
125DNA methylation (GO:0006306)3.01537410
126regulation of spindle checkpoint (GO:0090231)3.00901099
127centriole replication (GO:0007099)2.99977941
128regulation of uterine smooth muscle contraction (GO:0070472)2.97121451
129nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.95181878
130regulation of acrosome reaction (GO:0060046)2.93770262
131regulation of meiosis I (GO:0060631)2.88627423
132lactate metabolic process (GO:0006089)2.86968505
133single strand break repair (GO:0000012)2.85684859
134chaperone-mediated protein complex assembly (GO:0051131)2.84673924
135UTP biosynthetic process (GO:0006228)2.84650551
136peptidyl-glutamic acid modification (GO:0018200)2.84649188
137alditol metabolic process (GO:0019400)2.78177006
138polyol catabolic process (GO:0046174)2.77665903
139microtubule polymerization or depolymerization (GO:0031109)2.74693218
140regulation of centriole replication (GO:0046599)2.71294892
141carnitine transport (GO:0015879)2.71031279
142amino-acid betaine transport (GO:0015838)2.71031279
143mitotic sister chromatid cohesion (GO:0007064)2.63005649
144left/right axis specification (GO:0070986)2.62983495
145protein refolding (GO:0042026)2.60421977
146carnitine transmembrane transport (GO:1902603)2.60105832
147sequestering of actin monomers (GO:0042989)2.55879498
148UTP metabolic process (GO:0046051)2.52001063
149glycerol metabolic process (GO:0006071)2.51206094
150interferon-gamma secretion (GO:0072643)2.46319459
151gene silencing (GO:0016458)2.44817990
152glycolytic process (GO:0006096)2.44200954
153fusion of sperm to egg plasma membrane (GO:0007342)13.5325338
154cilium or flagellum-dependent cell motility (GO:0001539)12.5104701
155multicellular organism reproduction (GO:0032504)12.0388582
156sperm motility (GO:0030317)11.8772099
157cell wall macromolecule catabolic process (GO:0016998)11.5667175
158cell wall macromolecule metabolic process (GO:0044036)11.5667175
159acrosome assembly (GO:0001675)11.4417750
160sperm-egg recognition (GO:0035036)11.1824436
161axonemal dynein complex assembly (GO:0070286)10.5155481
162regulation of DNA methylation (GO:0044030)10.3645827
163plasma membrane fusion (GO:0045026)10.2987834
164cell-cell recognition (GO:0009988)10.1401443
165acrosome reaction (GO:0007340)10.0681891

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.40279286
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.07236853
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.02396836
4EZH2_22144423_ChIP-Seq_EOC_Human4.17099948
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.02134752
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.02134752
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.02134752
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.42258012
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.36561894
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.08612084
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.71114017
12PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.66701792
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.56075784
14VDR_22108803_ChIP-Seq_LS180_Human2.46687521
15PCGF2_27294783_Chip-Seq_ESCs_Mouse2.45934244
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.36499777
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.19178340
18E2F7_22180533_ChIP-Seq_HELA_Human2.19084602
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.15219536
20KAP1_22055183_ChIP-Seq_ESCs_Mouse2.04074300
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.03144330
22EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.90670838
23BP1_19119308_ChIP-ChIP_Hs578T_Human1.85370963
24KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.82487882
25ELK4_26923725_Chip-Seq_MESODERM_Mouse1.82090963
26GATA1_26923725_Chip-Seq_HPCs_Mouse1.80780687
27STAT1_17558387_ChIP-Seq_HELA_Human1.80081313
28STAT6_21828071_ChIP-Seq_BEAS2B_Human1.78671227
29CBX2_27304074_Chip-Seq_ESCs_Mouse1.78298218
30CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.77491282
31NFE2_27457419_Chip-Seq_LIVER_Mouse1.76158028
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.75213633
33TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.73505754
34HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.71115700
35SUZ12_27294783_Chip-Seq_NPCs_Mouse1.70964807
36FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.65716560
37MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.64905592
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.61563467
39TOP2B_26459242_ChIP-Seq_MCF-7_Human1.61417299
40GBX2_23144817_ChIP-Seq_PC3_Human1.60671485
41RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.60048633
42TAL1_26923725_Chip-Seq_HPCs_Mouse1.59337394
43EP300_21415370_ChIP-Seq_HL-1_Mouse1.58389260
44RNF2_27304074_Chip-Seq_NSC_Mouse1.57054010
45KDM2B_26808549_Chip-Seq_REH_Human1.55779026
46ZNF274_21170338_ChIP-Seq_K562_Hela1.55701859
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.54567439
48TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.54312982
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47631224
50CBP_20019798_ChIP-Seq_JUKART_Human1.47631224
51WDR5_24793694_ChIP-Seq_LNCAP_Human1.46040156
52RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45267870
53FOXM1_26456572_ChIP-Seq_MCF-7_Human1.45213555
54NANOG_18555785_Chip-Seq_ESCs_Mouse1.43508567
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.43242301
56GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.43141808
57FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41945199
58GATA3_21867929_ChIP-Seq_CD8_Mouse1.39522557
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38307666
60OCT4_18555785_Chip-Seq_ESCs_Mouse1.38049829
61EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.37882364
62SMAD4_21799915_ChIP-Seq_A2780_Human1.36405185
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36082464
64CRX_20693478_ChIP-Seq_RETINA_Mouse1.36061177
65EZH2_27294783_Chip-Seq_NPCs_Mouse1.35832914
66RUNX1_26923725_Chip-Seq_HPCs_Mouse1.35706672
67DROSHA_22980978_ChIP-Seq_HELA_Human1.34926216
68FLI1_21867929_ChIP-Seq_TH2_Mouse1.33364070
69PRDM14_20953172_ChIP-Seq_ESCs_Human1.33137302
70GATA3_21867929_ChIP-Seq_TH1_Mouse1.32359961
71MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32108175
72SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31834977
73P53_22387025_ChIP-Seq_ESCs_Mouse1.30398577
74AHR_22903824_ChIP-Seq_MCF-7_Human1.28441308
75KLF4_18555785_Chip-Seq_ESCs_Mouse1.28097937
76TCF4_23295773_ChIP-Seq_U87_Human1.27732630
77ESRRB_18555785_Chip-Seq_ESCs_Mouse1.27656551
78CMYC_18555785_Chip-Seq_ESCs_Mouse1.27401336
79P300_18555785_Chip-Seq_ESCs_Mouse1.25815509
80EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.25685068
81STAT3_18555785_Chip-Seq_ESCs_Mouse1.25512057
82SOX2_22085726_ChIP-Seq_NPCs_Mouse1.24931435
83CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24477106
84OCT4_21477851_ChIP-Seq_ESCs_Mouse1.23624447
85GF1_26923725_Chip-Seq_HPCs_Mouse1.23493697
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23170610
87TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23170610
88SMAD4_21741376_ChIP-Seq_EPCs_Human1.22121146
89MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21254549
90SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.20271335
91SUZ12_18555785_Chip-Seq_ESCs_Mouse1.20094697
92PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.18836368
93CTCF_18555785_Chip-Seq_ESCs_Mouse1.18626433
94LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.18430657
95SMRT_27268052_Chip-Seq_Bcells_Human1.18262992
96AR_21909140_ChIP-Seq_LNCAP_Human1.18033755
97STAT3_23295773_ChIP-Seq_U87_Human1.17520020
98REST_21632747_ChIP-Seq_MESCs_Mouse1.17306061
99SMAD_19615063_ChIP-ChIP_OVARY_Human1.17294925
100SOX2_18555785_Chip-Seq_ESCs_Mouse1.16700439
101CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16101596
102STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14921648
103CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13649502
104RUNX1_27457419_Chip-Seq_LIVER_Mouse1.13586842
105AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13351357
106TAF15_26573619_Chip-Seq_HEK293_Human1.12829288
107NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.12720044
108NANOG_20526341_ChIP-Seq_ESCs_Human1.12584897
109CBP_21632823_ChIP-Seq_H3396_Human1.10736453
110ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10510301
111ZFX_18555785_Chip-Seq_ESCs_Mouse1.10504210
112TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10149518
113AR_25329375_ChIP-Seq_VCAP_Human1.09737663
114P53_21459846_ChIP-Seq_SAOS-2_Human1.09500574
115LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09467450
116PU1_27457419_Chip-Seq_LIVER_Mouse1.08485490
117TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.07963882
118SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.07803439
119E2F1_18555785_Chip-Seq_ESCs_Mouse1.07342626
120NMYC_18555785_Chip-Seq_ESCs_Mouse1.07272188
121CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06455912
122SPI1_26923725_Chip-Seq_HPCs_Mouse1.05148725
123RUNX2_22187159_ChIP-Seq_PCA_Human1.05113347
124FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04968370
125GF1B_26923725_Chip-Seq_HPCs_Mouse1.04248283
126ARNT_22903824_ChIP-Seq_MCF-7_Human1.02758836
127ERG_20517297_ChIP-Seq_VCAP_Human1.02485646
128SMAD1_18555785_Chip-Seq_ESCs_Mouse1.01721797
129RAD21_21589869_ChIP-Seq_MESCs_Mouse0.99409534
130ESET_19884257_ChIP-Seq_ESCs_Mouse0.98711698
131EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98090731
132FOXO3_23340844_ChIP-Seq_DLD1_Human0.97465434
133PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97045006
134GATA1_19941827_ChIP-Seq_MEL86_Mouse0.96016924
135RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95984056
136IRF1_19129219_ChIP-ChIP_H3396_Human0.95746247
137TP63_23658742_ChIP-Seq_EP156T_Human0.95254055
138PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.94492021
139LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93179366
140NFYB_21822215_ChIP-Seq_K562_Human0.92702355
141TP53_16413492_ChIP-PET_HCT116_Human0.92103094
142NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.91895568
143SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91802746
144MYC_27129775_Chip-Seq_CORNEA_Mouse0.90781062
145SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.90741590
146SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90722600
147STAT3_18555785_ChIP-Seq_MESCs_Mouse0.90662216
148PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.90276355
149TBL1_22424771_ChIP-Seq_293T_Human0.90210979
150SALL4_22934838_ChIP-ChIP_CD34+_Human0.88323298
151ESR1_20079471_ChIP-ChIP_T-47D_Human0.87101328
152FOXH1_21741376_ChIP-Seq_EPCs_Human0.85246671
153SMAD3_21741376_ChIP-Seq_EPCs_Human0.83799604
154TP63_19390658_ChIP-ChIP_HaCaT_Human0.83796165
155KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.81870807
156SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79652239
157FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.78903031
158CTNNB1_20460455_ChIP-Seq_HCT116_Human0.78187514
159GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.76955625
160E2F4_17652178_ChIP-ChIP_JURKAT_Human0.76654704
161NR3C1_21868756_ChIP-Seq_MCF10A_Human0.76007747
162KLF4_19829295_ChIP-Seq_ESCs_Human0.74542315
163BCAT_22108803_ChIP-Seq_LS180_Human0.74402009
164TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.74364658
165ER_23166858_ChIP-Seq_MCF-7_Human0.74012446
166SALL1_21062744_ChIP-ChIP_HESCs_Human0.73387865
167STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.72856484
168P300_19829295_ChIP-Seq_ESCs_Human0.72804615
169ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.72471582
170CDX2_22108803_ChIP-Seq_LS180_Human0.71874676
171EWS_26573619_Chip-Seq_HEK293_Human0.71850773
172BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.71223525
173AR_20517297_ChIP-Seq_VCAP_Human0.70881049
174ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.70136950
175CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.68401509
176CTBP1_25329375_ChIP-Seq_LNCAP_Human0.68236983
177PPAR_26484153_Chip-Seq_NCI-H1993_Human0.68079470

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.86520399
2MP0001929_abnormal_gametogenesis5.61629278
3MP0008789_abnormal_olfactory_epithelium5.07351296
4MP0008877_abnormal_DNA_methylation5.05126950
5MP0005499_abnormal_olfactory_system4.31813156
6MP0005394_taste/olfaction_phenotype4.31813156
7MP0002653_abnormal_ependyma_morphology4.14659169
8MP0006292_abnormal_olfactory_placode3.99892404
9MP0002210_abnormal_sex_determination3.79180802
10MP0002161_abnormal_fertility/fecundity3.35859884
11MP0001145_abnormal_male_reproductive3.11698717
12MP0000653_abnormal_sex_gland2.90104616
13MP0010030_abnormal_orbit_morphology2.78976891
14MP0010234_abnormal_vibrissa_follicle2.74497805
15MP0003890_abnormal_embryonic-extraembry2.65723046
16MP0003646_muscle_fatigue2.54568420
17MP0005360_urolithiasis2.35200947
18MP0002138_abnormal_hepatobiliary_system2.26739015
19MP0005623_abnormal_meninges_morphology2.08798030
20MP0001984_abnormal_olfaction2.02164735
21MP0005410_abnormal_fertilization14.6154395
22MP0002160_abnormal_reproductive_system1.86086884
23MP0003077_abnormal_cell_cycle1.76379978
24MP0005670_abnormal_white_adipose1.72026952
25MP0003183_abnormal_peptide_metabolism1.63715676
26MP0002282_abnormal_trachea_morphology1.58680085
27MP0000566_synostosis1.54006953
28MP0010307_abnormal_tumor_latency1.47015282
29MP0003252_abnormal_bile_duct1.37575980
30MP0009046_muscle_twitch1.35150984
31MP0010368_abnormal_lymphatic_system1.31048759
32MP0005647_abnormal_sex_gland1.30806420
33MP0000678_abnormal_parathyroid_gland1.25039630
34MP0008058_abnormal_DNA_repair1.24752603
35MP0010678_abnormal_skin_adnexa1.23047446
36MP0002233_abnormal_nose_morphology1.22230468
37MP0008875_abnormal_xenobiotic_pharmacok1.20033931
38MP0000762_abnormal_tongue_morphology1.14240908
39MP0005389_reproductive_system_phenotype1.11922202
40MP0005646_abnormal_pituitary_gland1.10935974
41MP0005645_abnormal_hypothalamus_physiol1.10580676
42MP0004043_abnormal_pH_regulation1.09539548
43MP0009379_abnormal_foot_pigmentation1.08729373
44MP0009840_abnormal_foam_cell1.08140629
45MP0001765_abnormal_ion_homeostasis1.07366061
46MP0002102_abnormal_ear_morphology1.05140062
47MP0003699_abnormal_female_reproductive1.03322030
48MP0010094_abnormal_chromosome_stability0.98992853
49MP0008995_early_reproductive_senescence0.95644213
50MP0002876_abnormal_thyroid_physiology0.93710842
51MP0000631_abnormal_neuroendocrine_gland0.92660187
52MP0003718_maternal_effect0.92615803
53MP0001119_abnormal_female_reproductive0.90871775
54MP0002277_abnormal_respiratory_mucosa0.89687052
55MP0002735_abnormal_chemical_nociception0.89075538
56MP0008932_abnormal_embryonic_tissue0.87810747
57MP0004233_abnormal_muscle_weight0.81063308
58MP0001664_abnormal_digestion0.80495613
59MP0003121_genomic_imprinting0.79036862
60MP0002127_abnormal_cardiovascular_syste0.74774387
61MP0005085_abnormal_gallbladder_physiolo0.73593830
62MP0004142_abnormal_muscle_tone0.73234103
63MP0001672_abnormal_embryogenesis/_devel0.72685783
64MP0005380_embryogenesis_phenotype0.72685783
65MP0000350_abnormal_cell_proliferation0.70086913
66MP0000049_abnormal_middle_ear0.69904282
67MP0009780_abnormal_chondrocyte_physiolo0.69042393
68MP0003656_abnormal_erythrocyte_physiolo0.68104483
69MP0003879_abnormal_hair_cell0.67657373
70MP0002928_abnormal_bile_duct0.66795818
71MP0005451_abnormal_body_composition0.65548139
72MP0004084_abnormal_cardiac_muscle0.65260383
73MP0001764_abnormal_homeostasis0.64488477
74MP0000383_abnormal_hair_follicle0.63037716
75MP0003119_abnormal_digestive_system0.62058507
76MP0001666_abnormal_nutrient_absorption0.61626438
77MP0008057_abnormal_DNA_replication0.60756124
78MP0002971_abnormal_brown_adipose0.56050159
79MP0002084_abnormal_developmental_patter0.55892256
80MP0002272_abnormal_nervous_system0.53199603
81MP0002796_impaired_skin_barrier0.53046607
82MP0003941_abnormal_skin_development0.51934774
83MP0009115_abnormal_fat_cell0.51257150
84MP0003786_premature_aging0.51133871
85MP0002168_other_aberrant_phenotype0.50528283
86MP0003878_abnormal_ear_physiology0.49543457
87MP0005377_hearing/vestibular/ear_phenot0.49543457
88MP0006138_congestive_heart_failure0.49511493
89MP0001963_abnormal_hearing_physiology0.49506163
90MP0003453_abnormal_keratinocyte_physiol0.49149155
91MP0000733_abnormal_muscle_development0.48431406
92MP0004036_abnormal_muscle_relaxation0.48032242
93MP0000015_abnormal_ear_pigmentation0.47795621
94MP0004957_abnormal_blastocyst_morpholog0.46904315
95MP0003950_abnormal_plasma_membrane0.46833146
96MP0002234_abnormal_pharynx_morphology0.46172115
97MP0000751_myopathy0.45990635
98MP0000427_abnormal_hair_cycle0.45640757
99MP0005023_abnormal_wound_healing0.45434556
100MP0005319_abnormal_enzyme/_coenzyme0.45406915
101MP0005501_abnormal_skin_physiology0.44119657
102MP0005310_abnormal_salivary_gland0.44039906
103MP0002638_abnormal_pupillary_reflex0.43981601
104MP0005636_abnormal_mineral_homeostasis0.43699743
105MP0001881_abnormal_mammary_gland0.43502021
106MP0003935_abnormal_craniofacial_develop0.43434178
107MP0002734_abnormal_mechanical_nocicepti0.42398199
108MP0002089_abnormal_postnatal_growth/wei0.41162509
109MP0005395_other_phenotype0.40204584
110MP0005551_abnormal_eye_electrophysiolog0.39578643
111MP0003787_abnormal_imprinting0.39434672
112MP0005253_abnormal_eye_physiology0.39273903
113MP0001293_anophthalmia0.38582536
114MP0002295_abnormal_pulmonary_circulatio0.37616771
115MP0003115_abnormal_respiratory_system0.36648955
116MP0005257_abnormal_intraocular_pressure0.36275017
117MP0003111_abnormal_nucleus_morphology0.34180463
118MP0003011_delayed_dark_adaptation0.31962853
119MP0002269_muscular_atrophy0.31860144
120MP0003861_abnormal_nervous_system0.31528156
121MP0002736_abnormal_nociception_after0.30797474
122MP0004270_analgesia0.30705600
123MP0001502_abnormal_circadian_rhythm0.30665312
124MP0006072_abnormal_retinal_apoptosis0.29656582
125MP0000579_abnormal_nail_morphology0.28946468
126MP0004134_abnormal_chest_morphology0.28361009
127MP0001919_abnormal_reproductive_system0.28160153
128MP0001324_abnormal_eye_pigmentation0.27951766
129MP0001545_abnormal_hematopoietic_system0.27156861
130MP0005397_hematopoietic_system_phenotyp0.27156861
131MP0002132_abnormal_respiratory_system0.27093983
132MP0003693_abnormal_embryo_hatching0.26312756
133MP0005391_vision/eye_phenotype0.26166386
134MP0000358_abnormal_cell_content/0.25937096
135MP0001529_abnormal_vocalization0.25797236
136MP0006276_abnormal_autonomic_nervous0.25369902
137MP0003959_abnormal_lean_body0.25322513
138MP0000685_abnormal_immune_system0.25317244
139MP0002152_abnormal_brain_morphology0.25271364
140MP0010386_abnormal_urinary_bladder0.24973070
141MP0002693_abnormal_pancreas_physiology0.24614953
142MP0000462_abnormal_digestive_system0.23928337
143MP0008007_abnormal_cellular_replicative0.23899975
144MP0004510_myositis0.23578451
145MP0001730_embryonic_growth_arrest0.23217907
146MP0009278_abnormal_bone_marrow0.22714734
147MP0009697_abnormal_copulation0.22672968
148MP0003942_abnormal_urinary_system0.22355467
149MP0002752_abnormal_somatic_nervous0.21351239
150MP0002405_respiratory_system_inflammati0.20269850
151MP0002169_no_abnormal_phenotype0.20075156
152MP0001986_abnormal_taste_sensitivity0.20048005
153MP0002873_normal_phenotype0.19830171
154MP0000534_abnormal_ureter_morphology0.19640713
155MP0005195_abnormal_posterior_eye0.19470362
156MP0003937_abnormal_limbs/digits/tail_de0.19437181
157MP0004145_abnormal_muscle_electrophysio0.19332772
158MP0001851_eye_inflammation0.19148179
159MP0002139_abnormal_hepatobiliary_system0.19053485

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)8.79581127
2Abnormal respiratory motile cilium morphology (HP:0005938)8.79581127
3Abnormal ciliary motility (HP:0012262)8.57493310
4Rhinitis (HP:0012384)7.96856842
5Chronic bronchitis (HP:0004469)7.37522427
6Infertility (HP:0000789)6.40667833
7Nasal polyposis (HP:0100582)6.01999205
8Bronchiectasis (HP:0002110)4.99708359
9Abnormality of the nasal mucosa (HP:0000433)4.95759366
10Bronchitis (HP:0012387)4.52731857
11Male infertility (HP:0003251)4.50409785
12Nephronophthisis (HP:0000090)4.49492149
13Abnormality of abdominal situs (HP:0011620)4.06216920
14Abdominal situs inversus (HP:0003363)4.06216920
15Osteomalacia (HP:0002749)3.95853962
16Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.95449342
17Lip pit (HP:0100267)3.85199286
18Recurrent sinusitis (HP:0011108)3.80130695
19Abnormality of the renal medulla (HP:0100957)3.49805264
20Facial hemangioma (HP:0000329)3.32401924
21Abnormal spermatogenesis (HP:0008669)3.29576835
22Malnutrition (HP:0004395)3.27385712
23Recurrent otitis media (HP:0000403)3.20655306
24Muscle stiffness (HP:0003552)3.16230187
25Hypophosphatemic rickets (HP:0004912)3.12376322
26Papillary thyroid carcinoma (HP:0002895)3.09381166
27Molar tooth sign on MRI (HP:0002419)3.06842147
28Abnormality of midbrain morphology (HP:0002418)3.06842147
29Medial flaring of the eyebrow (HP:0010747)2.83747081
30Aplasia/Hypoplasia of the fovea (HP:0008060)2.82552686
31Hypoplasia of the fovea (HP:0007750)2.82552686
32Tubulointerstitial nephritis (HP:0001970)2.81774851
33Tubular atrophy (HP:0000092)2.72876696
34Septo-optic dysplasia (HP:0100842)2.71327426
35Oligodactyly (hands) (HP:0001180)2.65562383
36Anterior segment dysgenesis (HP:0007700)2.63104382
37Recurrent bronchitis (HP:0002837)2.62871478
38Hyperactive renin-angiotensin system (HP:0000841)2.61196739
39Tubulointerstitial abnormality (HP:0001969)2.57791753
40Premature ovarian failure (HP:0008209)2.46609028
41Abnormality of the fovea (HP:0000493)2.46430451
42Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.45353218
43Absent septum pellucidum (HP:0001331)2.42150720
44Azoospermia (HP:0000027)2.39734010
45Cone-rod dystrophy (HP:0000548)2.34152485
46Tubulointerstitial fibrosis (HP:0005576)2.30130020
47Aplasia of the musculature (HP:0100854)2.24203131
48Postaxial foot polydactyly (HP:0001830)2.24041211
49Pancreatic fibrosis (HP:0100732)2.21416071
50Spinal cord compression (HP:0002176)2.18130187
51Short tibia (HP:0005736)2.17307092
52Skin pits (HP:0100276)2.15314985
53Impulsivity (HP:0100710)2.12936237
54Congenital hepatic fibrosis (HP:0002612)2.11988931
55Microglossia (HP:0000171)2.11578572
56Apathy (HP:0000741)2.11394182
57Gonadotropin excess (HP:0000837)2.08895265
58Abnormality of the septum pellucidum (HP:0007375)2.07512689
59Striae distensae (HP:0001065)2.07262777
60Truncal obesity (HP:0001956)2.05765930
61Chromsome breakage (HP:0040012)2.03360108
62Diminished motivation (HP:0000745)2.02786900
63Hypokinesia (HP:0002375)2.01348185
64Abnormality of the renal cortex (HP:0011035)2.00024137
65Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.7635015
66Dynein arm defect of respiratory motile cilia (HP:0012255)12.3358949
67Absent/shortened dynein arms (HP:0200106)12.3358949
68Abnormal respiratory motile cilium physiology (HP:0012261)10.0489034
69Metaphyseal irregularity (HP:0003025)1.97931922
70Posterior subcapsular cataract (HP:0007787)1.95303722
71Decreased circulating renin level (HP:0003351)1.94850790
72Chromosomal breakage induced by crosslinking agents (HP:0003221)1.94690994
73Aplasia/Hypoplasia of the tibia (HP:0005772)1.93656819
74Stage 5 chronic kidney disease (HP:0003774)1.90915550
75Lower limb hyperreflexia (HP:0002395)1.89948518
76Capillary hemangiomas (HP:0005306)1.88969365
77Subcapsular cataract (HP:0000523)1.88739176
78Aplasia/Hypoplasia of the tongue (HP:0010295)1.85153751
79Stillbirth (HP:0003826)1.84795603
80Conjunctival telangiectasia (HP:0000524)1.84032464
81Cystic liver disease (HP:0006706)1.83897191
82Postaxial hand polydactyly (HP:0001162)1.81552290
83Abnormal drinking behavior (HP:0030082)1.80820629
84Polydipsia (HP:0001959)1.80820629
85Oligodactyly (HP:0012165)1.79754655
86Abnormality of monocarboxylic acid metabolism (HP:0010996)1.78497401
87Atelectasis (HP:0100750)1.78092293
88Facial cleft (HP:0002006)1.76966298
89Congenital primary aphakia (HP:0007707)1.76929874
90Intrahepatic cholestasis (HP:0001406)1.76419577
91Loss of speech (HP:0002371)1.76314834
92Gait imbalance (HP:0002141)1.75824995
93Abnormality of permanent molar morphology (HP:0011071)1.75703624
94Abnormality of the dental root (HP:0006486)1.75703624
95Taurodontia (HP:0000679)1.75703624
96Fair hair (HP:0002286)1.75351250
97Median cleft lip (HP:0000161)1.75118745
98Aplasia/Hypoplasia of the macula (HP:0008059)1.72301981
99Abnormality of the lower motor neuron (HP:0002366)1.71596671
100Abnormal biliary tract physiology (HP:0012439)1.69763875
101Bile duct proliferation (HP:0001408)1.69763875
102Abnormality of the labia minora (HP:0012880)1.68513727
103Urethral obstruction (HP:0000796)1.68202489
104Anhidrosis (HP:0000970)1.68163197
105Hypoplasia of the capital femoral epiphysis (HP:0003090)1.67223450
106Abnormal gallbladder physiology (HP:0012438)1.66666820
107Cholecystitis (HP:0001082)1.66666820
108True hermaphroditism (HP:0010459)1.66482280
109Oculomotor apraxia (HP:0000657)1.66165096
110Hip contracture (HP:0003273)1.65670999
111Abnormality of molar (HP:0011077)1.65539737
112Abnormality of molar morphology (HP:0011070)1.65539737
113Maternal diabetes (HP:0009800)1.64561456
114Wrist flexion contracture (HP:0001239)1.63127138
115Fibular hypoplasia (HP:0003038)1.62726602
116Enlarged penis (HP:0000040)1.62518613
117Chronic sinusitis (HP:0011109)1.61213890
118Rickets (HP:0002748)1.60449180
119Renal dysplasia (HP:0000110)1.60411587
120Congenital sensorineural hearing impairment (HP:0008527)1.60110588
121Abnormality of the dental pulp (HP:0006479)1.59965222
122Short ribs (HP:0000773)1.58905366
123Dysdiadochokinesis (HP:0002075)1.58273433
124Abnormality of dentin (HP:0010299)1.57657537
125Thyroid carcinoma (HP:0002890)1.55986599
126Abnormality of renal excretion (HP:0011036)1.55612723
127Aplasia/Hypoplasia affecting the retina (HP:0008061)1.54431778
128Abnormality of the salivary glands (HP:0010286)1.52720949
129Decreased central vision (HP:0007663)1.52362157
130Tongue fasciculations (HP:0001308)1.52130804
131Nephrogenic diabetes insipidus (HP:0009806)1.50454465
132Pancreatic cysts (HP:0001737)1.49646013
133Supernumerary spleens (HP:0009799)1.48104083
134Absent frontal sinuses (HP:0002688)1.47551006
135Aplasia/Hypoplasia of the lens (HP:0008063)1.47355336
136Dyschromatopsia (HP:0007641)1.47344853
137Genital tract atresia (HP:0001827)1.44111736
138Heterotopia (HP:0002282)1.41945869
139Short thorax (HP:0010306)1.39271490
140J-shaped sella turcica (HP:0002680)1.38963806
141Bell-shaped thorax (HP:0001591)1.36877553
142Amyotrophic lateral sclerosis (HP:0007354)1.36348698
143Occipital encephalocele (HP:0002085)1.35966684
144Muscle fibrillation (HP:0010546)1.35896046
145Poor coordination (HP:0002370)1.35352955
146Vaginal atresia (HP:0000148)1.35130441
147Impaired proprioception (HP:0010831)1.31004570
148Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.27931380
149Absent epiphyses (HP:0010577)1.27931380
150Spastic tetraparesis (HP:0001285)1.27254486
151Nephropathy (HP:0000112)1.23650657
152Chronic hepatic failure (HP:0100626)1.22906227
153Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.22107725
154Deformed sella turcica (HP:0002681)1.21598399
155Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.20974840
156Retinal dysplasia (HP:0007973)1.19902183
157Abnormal urine output (HP:0012590)1.18229388
158Choroideremia (HP:0001139)1.18039562
159Aplasia/Hypoplasia of the fibula (HP:0006492)1.16038070
160Bundle branch block (HP:0011710)1.15945772
161Abnormality of saccadic eye movements (HP:0000570)1.12784445
162Congenital malformation of the right heart (HP:0011723)1.11967757

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.39848021
2PDK38.39848021
3MAP3K135.60608391
4PDK25.30843423
5PRKD34.79714710
6TESK14.78410862
7ICK3.19609494
8PTK2B2.57259707
9CDK92.53780257
10WNK42.41095941
11STK392.31712298
12MET2.31417267
13MST42.06198051
14RAF11.94449839
15PNCK1.77866449
16STK381.77372604
17PRKCI1.70615798
18NEK21.69701024
19CDK121.65855887
20CDK81.61822412
21STK38L1.56587927
22EIF2AK31.49854852
23DMPK1.40643796
24CDK191.36206135
25CDK71.29377391
26MAPK151.25456283
27TTK1.19336084
28DYRK1B1.13317793
29STK31.08456431
30KSR11.07342352
31MAP3K61.02906389
32DYRK31.02896229
33TRIM281.02702392
34MAP3K81.00847943
35NEK90.98050007
36PDK10.96113499
37PLK40.93211613
38TYRO30.92346095
39MUSK0.91337762
40EEF2K0.91062775
41CHEK20.86909946
42BRAF0.86403746
43PIM10.84967488
44TNIK0.82847175
45PTK20.82419759
46TNK20.76209082
47MAP2K70.75402222
48MAP3K70.73864372
49BUB10.73379949
50ERBB40.72348635
51BMPR20.71423224
52CCNB10.70455413
53WNK10.69337465
54PASK0.67737037
55LATS10.67448881
56MARK30.67434983
57PINK10.67316560
58LRRK20.59279607
59PLK30.58880295
60MAPKAPK50.57396342
61LMTK20.56983242
62TIE10.56365271
63AURKB0.53373403
64MAP3K40.50586409
65IRAK10.49639765
66ZAK0.48178895
67PDPK10.48085802
68CDC70.47836634
69PKN10.47428577
70CAMK1G0.45486818
71NUAK10.44913725
72CHEK10.44873452
73LATS20.44665268
74ACVR1B0.44518780
75PIK3CG0.43612587
76MAP3K30.40620904
77PLK10.38960724
78TRPM70.38957658
79PRKACB0.37855211
80ATM0.37509947
81ATR0.37500159
82NTRK30.35556975
83MOS0.33122007
84PRKAA10.32494283
85BRSK10.31976006
86MAP2K60.31808312
87ARAF0.31221339
88NTRK20.30216821
89PAK10.28914717
90BRSK20.28895242
91TGFBR10.28535619
92CSNK1E0.27626014
93NME10.25773230
94OXSR10.24756427
95CSK0.24213135
96PBK0.23291263
97EGFR0.21965679
98CDK30.21240697
99MARK20.21068236
100KSR20.20709202
101MAPKAPK30.20477240
102WEE10.20234540
103CSNK1G10.20207047
104STK100.20156798
105MAPK10.19300705
106MAP3K90.19197846
107CHUK0.18878815
108VRK10.18713296
109PRKCG0.18192627
110STK110.17802949
111SRPK10.17222153
112CAMK2A0.17001965
113PAK60.14325355
114TAOK10.12948620
115CAMKK10.12872016
116TAOK30.12686218
117AKT30.12584780
118STK240.12043507
119MTOR0.11926855
120DYRK20.11712418
121PRKCQ0.11005285
122RPS6KB10.09748644
123AURKA0.09348807
124NEK60.06856557
125MELK0.06845908
126PRKG20.06720268
127PRKAA20.06514409
128CSNK1D0.06258069
129GSK3B0.05756049
130RIPK40.05538961
131MAPK130.05390895
132CDK10.04744663
133MAP3K10.04101888
134RPS6KA10.03798219
135MAP3K50.03744810
136CSNK2A10.03578674
137PRKG10.03135111
138BMPR1B0.03054293
139PRKCZ0.02671277
140IRAK20.02637468
141WNK30.02496075
142PRKACA0.01280113
143PRKDC0.01052863
144PDGFRB0.00916199
145CDK20.00671220
146MAP2K40.00479101
147PRKCA0.00321164
148MAPK8-0.0033110

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.81450650
2Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005334.34606518
3Caffeine metabolism_Homo sapiens_hsa002323.74656140
4Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.73387217
5Pyruvate metabolism_Homo sapiens_hsa006203.56393744
6Fatty acid biosynthesis_Homo sapiens_hsa000613.45053210
7Basal transcription factors_Homo sapiens_hsa030223.42340581
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.22148632
9Linoleic acid metabolism_Homo sapiens_hsa005913.20558873
10Mismatch repair_Homo sapiens_hsa034303.18440076
11Propanoate metabolism_Homo sapiens_hsa006402.70884165
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.67691086
13Glucagon signaling pathway_Homo sapiens_hsa049222.49409569
14Dorso-ventral axis formation_Homo sapiens_hsa043202.47387011
15Base excision repair_Homo sapiens_hsa034102.41703331
16Nucleotide excision repair_Homo sapiens_hsa034202.17998577
17Fanconi anemia pathway_Homo sapiens_hsa034602.16713303
18Pentose phosphate pathway_Homo sapiens_hsa000302.12570479
19Oocyte meiosis_Homo sapiens_hsa041142.12319265
20Ether lipid metabolism_Homo sapiens_hsa005651.99440863
21p53 signaling pathway_Homo sapiens_hsa041151.98557056
22Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.94614462
23Circadian rhythm_Homo sapiens_hsa047101.87673525
24Glycerophospholipid metabolism_Homo sapiens_hsa005641.86894687
25Glycerolipid metabolism_Homo sapiens_hsa005611.80361949
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.76699899
27Folate biosynthesis_Homo sapiens_hsa007901.70578851
28Selenocompound metabolism_Homo sapiens_hsa004501.61222231
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.58586008
30Carbohydrate digestion and absorption_Homo sapiens_hsa049731.58048207
31Huntingtons disease_Homo sapiens_hsa050161.53306219
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.52195109
33Olfactory transduction_Homo sapiens_hsa047401.47945398
34Amphetamine addiction_Homo sapiens_hsa050311.45036535
35DNA replication_Homo sapiens_hsa030301.42374918
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.32026927
37Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.27059620
38Gap junction_Homo sapiens_hsa045401.23427336
39PPAR signaling pathway_Homo sapiens_hsa033201.21330554
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.20377777
41mRNA surveillance pathway_Homo sapiens_hsa030151.18126022
42Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.16851155
43Mineral absorption_Homo sapiens_hsa049781.11586819
44Purine metabolism_Homo sapiens_hsa002301.09709118
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.09551682
46Ovarian steroidogenesis_Homo sapiens_hsa049131.06016409
47Renin secretion_Homo sapiens_hsa049241.05384456
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.01520520
49RNA transport_Homo sapiens_hsa030131.01343915
50Adherens junction_Homo sapiens_hsa045200.99299971
51Collecting duct acid secretion_Homo sapiens_hsa049660.98486265
52Thyroid cancer_Homo sapiens_hsa052160.96970950
53Arachidonic acid metabolism_Homo sapiens_hsa005900.94025092
54Phototransduction_Homo sapiens_hsa047440.91694675
55Cardiac muscle contraction_Homo sapiens_hsa042600.91578897
56Taste transduction_Homo sapiens_hsa047420.90951659
57Fructose and mannose metabolism_Homo sapiens_hsa000510.89019584
58Carbon metabolism_Homo sapiens_hsa012000.86625524
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85645549
60Antigen processing and presentation_Homo sapiens_hsa046120.83899844
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83502559
62Inositol phosphate metabolism_Homo sapiens_hsa005620.83452860
63Insulin secretion_Homo sapiens_hsa049110.83045905
64Phenylalanine metabolism_Homo sapiens_hsa003600.81936980
65Estrogen signaling pathway_Homo sapiens_hsa049150.79725269
66RNA degradation_Homo sapiens_hsa030180.79595331
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79240255
68Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.77529463
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75355125
70Long-term potentiation_Homo sapiens_hsa047200.74276493
71Synaptic vesicle cycle_Homo sapiens_hsa047210.73766314
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73052170
73Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70770501
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68959209
75ABC transporters_Homo sapiens_hsa020100.68570669
76Nicotine addiction_Homo sapiens_hsa050330.67932558
77Viral carcinogenesis_Homo sapiens_hsa052030.67087893
78Cell cycle_Homo sapiens_hsa041100.65472581
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65242902
80Regulation of autophagy_Homo sapiens_hsa041400.64158751
81TGF-beta signaling pathway_Homo sapiens_hsa043500.64001799
82Biosynthesis of amino acids_Homo sapiens_hsa012300.63984107
83mTOR signaling pathway_Homo sapiens_hsa041500.63781765
84Thyroid hormone synthesis_Homo sapiens_hsa049180.63147060
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62896898
86Fatty acid metabolism_Homo sapiens_hsa012120.62754891
87FoxO signaling pathway_Homo sapiens_hsa040680.61891113
88Serotonergic synapse_Homo sapiens_hsa047260.61098789
89Calcium signaling pathway_Homo sapiens_hsa040200.60985950
90beta-Alanine metabolism_Homo sapiens_hsa004100.60200891
91Fat digestion and absorption_Homo sapiens_hsa049750.59687873
92Herpes simplex infection_Homo sapiens_hsa051680.58993414
93VEGF signaling pathway_Homo sapiens_hsa043700.58430139
94Renin-angiotensin system_Homo sapiens_hsa046140.58407319
95Fatty acid degradation_Homo sapiens_hsa000710.58094424
96RNA polymerase_Homo sapiens_hsa030200.58020038
97cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57395098
98Glutathione metabolism_Homo sapiens_hsa004800.55986639
99Histidine metabolism_Homo sapiens_hsa003400.52319230
100Long-term depression_Homo sapiens_hsa047300.52085480
101Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50150516
102cAMP signaling pathway_Homo sapiens_hsa040240.48734982
103Hedgehog signaling pathway_Homo sapiens_hsa043400.47998592
104Chemical carcinogenesis_Homo sapiens_hsa052040.47944193
105Amoebiasis_Homo sapiens_hsa051460.47482969
106Tight junction_Homo sapiens_hsa045300.46920196
107Morphine addiction_Homo sapiens_hsa050320.46635399
108MicroRNAs in cancer_Homo sapiens_hsa052060.45545106
109Tyrosine metabolism_Homo sapiens_hsa003500.44960771
110Salivary secretion_Homo sapiens_hsa049700.43879993
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42028163
112Bile secretion_Homo sapiens_hsa049760.40326085
113Small cell lung cancer_Homo sapiens_hsa052220.38783718
114Endocytosis_Homo sapiens_hsa041440.38119461
115Metabolic pathways_Homo sapiens_hsa011000.36239364
116Homologous recombination_Homo sapiens_hsa034400.36045835
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.35531506
118GABAergic synapse_Homo sapiens_hsa047270.35436605
119Glutamatergic synapse_Homo sapiens_hsa047240.35403957
120Sphingolipid metabolism_Homo sapiens_hsa006000.35280336
121Vascular smooth muscle contraction_Homo sapiens_hsa042700.35115774
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.35078102
123Circadian entrainment_Homo sapiens_hsa047130.35051002
124Hepatitis B_Homo sapiens_hsa051610.32242923
125Notch signaling pathway_Homo sapiens_hsa043300.32120458
126HTLV-I infection_Homo sapiens_hsa051660.31823140
127Pancreatic secretion_Homo sapiens_hsa049720.31008381
128N-Glycan biosynthesis_Homo sapiens_hsa005100.30726680
129Retinol metabolism_Homo sapiens_hsa008300.29282261
130Pancreatic cancer_Homo sapiens_hsa052120.28645431
131Oxytocin signaling pathway_Homo sapiens_hsa049210.27644507
132ErbB signaling pathway_Homo sapiens_hsa040120.26440032
133Phagosome_Homo sapiens_hsa041450.26407296
134Cocaine addiction_Homo sapiens_hsa050300.26308627
135Asthma_Homo sapiens_hsa053100.24701504
136Gastric acid secretion_Homo sapiens_hsa049710.24262131
137AMPK signaling pathway_Homo sapiens_hsa041520.24259605
138Influenza A_Homo sapiens_hsa051640.24045357
139Colorectal cancer_Homo sapiens_hsa052100.23410335
140Renal cell carcinoma_Homo sapiens_hsa052110.22316506
141Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.20908826
142Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.20546842
143Hippo signaling pathway_Homo sapiens_hsa043900.20011157
144Central carbon metabolism in cancer_Homo sapiens_hsa052300.19866715
145Longevity regulating pathway - mammal_Homo sapiens_hsa042110.19511935
146Choline metabolism in cancer_Homo sapiens_hsa052310.18399791
147Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.18010493
148Transcriptional misregulation in cancer_Homo sapiens_hsa052020.16947921
149Non-homologous end-joining_Homo sapiens_hsa034500.15849694
150Ras signaling pathway_Homo sapiens_hsa040140.15468708
151Aldosterone synthesis and secretion_Homo sapiens_hsa049250.15329257
152Vitamin digestion and absorption_Homo sapiens_hsa049770.15187189
153Regulation of actin cytoskeleton_Homo sapiens_hsa048100.15060137
154Arginine and proline metabolism_Homo sapiens_hsa003300.14378734
155Prostate cancer_Homo sapiens_hsa052150.13835169
156Dopaminergic synapse_Homo sapiens_hsa047280.13711089
157Chemokine signaling pathway_Homo sapiens_hsa040620.13686958
158Wnt signaling pathway_Homo sapiens_hsa043100.13308542
159Protein digestion and absorption_Homo sapiens_hsa049740.10739844
160MAPK signaling pathway_Homo sapiens_hsa040100.08407735
161Legionellosis_Homo sapiens_hsa051340.07870452

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