CFAP65

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene has putative coiled-coil domains and may be a transmembrane protein. The chicken ortholog of this gene is involved in the Rose-comb mutation, which is a large chromosome inversion, resulting in altered comb morphology and defects in sperm motility. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1left/right pattern formation (GO:0060972)9.19328798
2regulation of cilium movement (GO:0003352)8.44673818
3left/right axis specification (GO:0070986)7.31170902
4primary alcohol catabolic process (GO:0034310)6.82487374
5ventricular system development (GO:0021591)6.72293594
6intraciliary transport (GO:0042073)6.61825445
7microtubule bundle formation (GO:0001578)6.39819781
8cilium organization (GO:0044782)6.35173136
9vitamin transmembrane transport (GO:0035461)6.25422225
10cilium assembly (GO:0042384)6.18990164
11ethanol metabolic process (GO:0006067)5.77997533
12protein localization to cilium (GO:0061512)5.28224490
13diterpenoid biosynthetic process (GO:0016102)5.24422076
14regulation of microtubule-based movement (GO:0060632)5.11066202
15centriole assembly (GO:0098534)5.10871510
16cellular component assembly involved in morphogenesis (GO:0010927)4.89329472
17response to xenobiotic stimulus (GO:0009410)4.78889800
18pyrimidine-containing compound transmembrane transport (GO:0072531)4.75415811
19cilium morphogenesis (GO:0060271)4.71159018
20microtubule-based movement (GO:0007018)4.70835526
21one-carbon compound transport (GO:0019755)4.54964308
22negative regulation of T cell differentiation in thymus (GO:0033085)4.51732896
23lung epithelium development (GO:0060428)4.51280821
24establishment of apical/basal cell polarity (GO:0035089)4.38448815
25ethanol oxidation (GO:0006069)4.36626828
26cell projection assembly (GO:0030031)4.35586143
27tolerance induction (GO:0002507)4.32460553
28sperm capacitation (GO:0048240)4.29187195
29regulation of interleukin-5 production (GO:0032674)4.27832609
30negative regulation of humoral immune response (GO:0002921)4.14492418
31negative regulation of B cell mediated immunity (GO:0002713)4.13007801
32negative regulation of immunoglobulin mediated immune response (GO:0002890)4.13007801
33glomerular epithelial cell development (GO:0072310)4.09861297
34nucleoside diphosphate phosphorylation (GO:0006165)4.02673492
35establishment or maintenance of monopolar cell polarity (GO:0061339)3.91939293
36establishment of monopolar cell polarity (GO:0061162)3.91939293
37retinoic acid metabolic process (GO:0042573)3.83890982
38terpenoid biosynthetic process (GO:0016114)3.73270177
39cytoplasmic microtubule organization (GO:0031122)3.64243724
40regulation of interleukin-13 production (GO:0032656)3.62844490
41lateral ventricle development (GO:0021670)3.62628668
42negative regulation of inclusion body assembly (GO:0090084)3.52956482
43regulation of germinal center formation (GO:0002634)3.49210217
44sperm motility (GO:0030317)3.45335872
45negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.41815490
46determination of left/right symmetry (GO:0007368)3.37006134
47exogenous drug catabolic process (GO:0042738)3.34086059
48microtubule depolymerization (GO:0007019)3.30949808
49retinol metabolic process (GO:0042572)3.28053680
50positive regulation of tolerance induction (GO:0002645)3.26948310
51glutathione derivative biosynthetic process (GO:1901687)3.26380718
52glutathione derivative metabolic process (GO:1901685)3.26380718
53determination of bilateral symmetry (GO:0009855)3.24145256
54microtubule polymerization or depolymerization (GO:0031109)3.22943280
55primary alcohol metabolic process (GO:0034308)3.18846968
56aldehyde catabolic process (GO:0046185)3.17243296
57specification of symmetry (GO:0009799)3.16633189
58establishment of tissue polarity (GO:0007164)3.14917785
59establishment of planar polarity (GO:0001736)3.14917785
60centriole replication (GO:0007099)3.14488111
61smoothened signaling pathway (GO:0007224)3.11775390
62O-glycan processing (GO:0016266)3.08125681
63axonemal dynein complex assembly (GO:0070286)21.1175692
64positive regulation of smoothened signaling pathway (GO:0045880)2.99015688
65nonmotile primary cilium assembly (GO:0035058)2.92118539
66hydrogen peroxide biosynthetic process (GO:0050665)2.87223371
67microtubule-based process (GO:0007017)2.81403176
68organelle assembly (GO:0070925)2.74568043
69photoreceptor cell maintenance (GO:0045494)2.72250968
70retinal rod cell development (GO:0046548)2.70250654
71drug catabolic process (GO:0042737)2.68079182
72phosphatidylcholine biosynthetic process (GO:0006656)2.67019596
73CDP-diacylglycerol biosynthetic process (GO:0016024)2.62785226
74carnitine metabolic process (GO:0009437)2.60416429
75apical protein localization (GO:0045176)2.58823296
76regulation of autophagic vacuole assembly (GO:2000785)2.57382191
77excretion (GO:0007588)2.55962647
78regulation of microtubule depolymerization (GO:0031114)2.54331020
79reactive oxygen species biosynthetic process (GO:1903409)2.51511415
80lateral sprouting from an epithelium (GO:0060601)2.50215758
81heart looping (GO:0001947)2.44447157
82multicellular organismal water homeostasis (GO:0050891)2.42629029
83hydrogen peroxide catabolic process (GO:0042744)2.37056289
84cornea development in camera-type eye (GO:0061303)2.35691507
85calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.35256734
86regulation of inclusion body assembly (GO:0090083)2.34392461
87neurotransmitter biosynthetic process (GO:0042136)2.33915474
88protein O-linked glycosylation (GO:0006493)2.33277879
89spermatid development (GO:0007286)2.31586857
90phosphatidylethanolamine biosynthetic process (GO:0006646)2.30046175
91CDP-diacylglycerol metabolic process (GO:0046341)2.27069484
92embryonic heart tube morphogenesis (GO:0003143)2.26984575
93regulation of tolerance induction (GO:0002643)2.25427680
94embryonic camera-type eye development (GO:0031076)2.24599150
95cilium or flagellum-dependent cell motility (GO:0001539)17.7920805
96cilium movement (GO:0003341)15.7833296
97motile cilium assembly (GO:0044458)14.5128980
98epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)14.4183537
99epithelial cilium movement (GO:0003351)13.7823270
100axoneme assembly (GO:0035082)10.2721294

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.64108822
2DROSHA_22980978_ChIP-Seq_HELA_Human3.08377746
3FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.04211876
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.79017348
5PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.60873622
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.39055273
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.33497959
8VDR_22108803_ChIP-Seq_LS180_Human2.17610631
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.04341514
10PIAS1_25552417_ChIP-Seq_VCAP_Human2.03142197
11AHR_22903824_ChIP-Seq_MCF-7_Human1.81460627
12FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.74667930
13ESR1_20079471_ChIP-ChIP_T-47D_Human1.74464321
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70490716
15STAT1_20625510_ChIP-Seq_HELA_Human1.66320323
16ARNT_22903824_ChIP-Seq_MCF-7_Human1.65658131
17NR3C1_21868756_ChIP-Seq_MCF10A_Human1.63144829
18FOXM1_26456572_ChIP-Seq_MCF-7_Human1.60798233
19AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.57933487
20TP63_23658742_ChIP-Seq_EP156T_Human1.56029211
21ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.53653371
22TRIM28_21343339_ChIP-Seq_HEK293_Human1.44771640
23TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.43404917
24FOXA1_25552417_ChIP-Seq_VCAP_Human1.42240361
25CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.41951942
26SMC4_20622854_ChIP-Seq_HELA_Human1.40306725
27ETV1_20927104_ChIP-Seq_GIST48_Human1.37328159
28PHF8_20622853_ChIP-Seq_HELA_Human1.36174386
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36120159
30ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35589162
31TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34467024
32TP53_18474530_ChIP-ChIP_U2OS_Human1.34160933
33TDRD3_21172665_ChIP-Seq_MCF-7_Human1.33884274
34TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.33512533
35SMAD4_21799915_ChIP-Seq_A2780_Human1.33111896
36PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.32785222
37RUNX1_27514584_Chip-Seq_MCF-7_Human1.32745376
38PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.32494732
39CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.30975106
40HNFA_21074721_ChIP-Seq_CACO-2_Human1.28734101
41SOX2_27498859_Chip-Seq_STOMACH_Mouse1.28524991
42SMRT_27268052_Chip-Seq_Bcells_Human1.26126154
43TP63_22573176_ChIP-Seq_HFKS_Human1.25910100
44ESR1_21235772_ChIP-Seq_MCF-7_Human1.24525219
45KLF5_25053715_ChIP-Seq_YYC3_Human1.24372914
46CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.23811569
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22326539
48RAD21_21589869_ChIP-Seq_MESCs_Mouse1.20763638
49CTNNB1_20460455_ChIP-Seq_HCT116_Human1.20043209
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19978393
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19534508
52SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.19051894
53RBPJ_21746931_ChIP-Seq_IB4_Human1.18345311
54FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17395315
55FOXA1_25329375_ChIP-Seq_VCAP_Human1.17395315
56EZH2_27294783_Chip-Seq_ESCs_Mouse1.17088481
57BCAT_22108803_ChIP-Seq_LS180_Human1.16784307
58AR_21572438_ChIP-Seq_LNCaP_Human1.13317129
59SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.12654538
60NFYA_21822215_ChIP-Seq_K562_Human1.12551984
61STAT3_23295773_ChIP-Seq_U87_Human1.11609333
62P63_26484246_Chip-Seq_KERATINOCYTES_Human1.11333315
63SMAD3_21741376_ChIP-Seq_HESCs_Human1.11256583
64SOX2_20726797_ChIP-Seq_SW620_Human1.11163129
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.10407246
66CBX2_22325352_ChIP-Seq_293T-Rex_Human1.09817406
67TBL1_22424771_ChIP-Seq_293T_Human1.09703445
68GATA4_25053715_ChIP-Seq_YYC3_Human1.09507921
69ESR2_21235772_ChIP-Seq_MCF-7_Human1.09218040
70CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08492141
71NFYB_21822215_ChIP-Seq_K562_Human1.07768785
72SMAD4_21741376_ChIP-Seq_EPCs_Human1.07563247
73CDX2_20551321_ChIP-Seq_CACO-2_Human1.06345769
74ER_23166858_ChIP-Seq_MCF-7_Human1.05785116
75TCF4_22108803_ChIP-Seq_LS180_Human1.05457236
76CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.05201566
77FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.05154987
78GATA6_21074721_ChIP-Seq_CACO-2_Human1.04828603
79SOX9_24532713_ChIP-Seq_HFSC_Mouse1.04745512
80CEBPB_22108803_ChIP-Seq_LS180_Human1.03546294
81EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.03192529
82CTCF_20526341_ChIP-Seq_ESCs_Human1.02831558
83PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02271272
84CTCF_27219007_Chip-Seq_Bcells_Human1.02171889
85YY1_22570637_ChIP-Seq_MALME-3M_Human1.02104127
86AR_20517297_ChIP-Seq_VCAP_Human1.01946043
87BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01382902
88PHF8_20622854_ChIP-Seq_HELA_Human1.00073041
89MYC_19829295_ChIP-Seq_ESCs_Human0.99994021
90OCT4_20526341_ChIP-Seq_ESCs_Human0.99752895
91ELF1_20517297_ChIP-Seq_JURKAT_Human0.99202754
92NCOR_22424771_ChIP-Seq_293T_Human0.98205330
93WDR5_24793694_ChIP-Seq_LNCAP_Human0.98019949
94TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.98002210
95GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.97995534
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97896659
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97896659
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97575248
99TCF4_23295773_ChIP-Seq_U87_Human0.95317497
100STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.95089461

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology7.28811260
2MP0008875_abnormal_xenobiotic_pharmacok6.03062927
3MP0002132_abnormal_respiratory_system4.69395983
4MP0001984_abnormal_olfaction4.40860717
5MP0009780_abnormal_chondrocyte_physiolo3.94003744
6MP0004133_heterotaxia3.73057195
7MP0004043_abnormal_pH_regulation3.69957865
8MP0002277_abnormal_respiratory_mucosa3.69465629
9MP0008789_abnormal_olfactory_epithelium3.00623742
10MP0005623_abnormal_meninges_morphology2.95511566
11MP0003878_abnormal_ear_physiology2.51935443
12MP0005377_hearing/vestibular/ear_phenot2.51935443
13MP0000566_synostosis2.26533498
14MP0002160_abnormal_reproductive_system2.25484409
15MP0004019_abnormal_vitamin_homeostasis2.17127418
16MP0002909_abnormal_adrenal_gland2.15768571
17MP0000383_abnormal_hair_follicle2.15304060
18MP0005499_abnormal_olfactory_system2.08126974
19MP0005394_taste/olfaction_phenotype2.08126974
20MP0002168_other_aberrant_phenotype1.99452199
21MP0010678_abnormal_skin_adnexa1.91954956
22MP0003136_yellow_coat_color1.89294117
23MP0002282_abnormal_trachea_morphology1.69532283
24MP0001765_abnormal_ion_homeostasis1.61818222
25MP0002876_abnormal_thyroid_physiology1.48130744
26MP0002638_abnormal_pupillary_reflex1.44000960
27MP0000678_abnormal_parathyroid_gland1.37766590
28MP0005395_other_phenotype1.36617781
29MP0002837_dystrophic_cardiac_calcinosis1.34574362
30MP0009046_muscle_twitch1.34527751
31MP0001485_abnormal_pinna_reflex1.32620821
32MP0002734_abnormal_mechanical_nocicepti1.31733957
33MP0003656_abnormal_erythrocyte_physiolo1.28710898
34MP0010234_abnormal_vibrissa_follicle1.25921047
35MP0005083_abnormal_biliary_tract1.24970493
36MP0002249_abnormal_larynx_morphology1.24890550
37MP0005636_abnormal_mineral_homeostasis1.22285169
38MP0005248_abnormal_Harderian_gland1.20593384
39MP0005389_reproductive_system_phenotype1.20370299
40MP0003890_abnormal_embryonic-extraembry1.14691656
41MP0005220_abnormal_exocrine_pancreas1.14081984
42MP0002735_abnormal_chemical_nociception1.13049714
43MP0002928_abnormal_bile_duct1.12197275
44MP0005365_abnormal_bile_salt1.09265146
45MP0003698_abnormal_male_reproductive1.08697267
46MP0005085_abnormal_gallbladder_physiolo1.06522458
47MP0001944_abnormal_pancreas_morphology1.05560182
48MP0001929_abnormal_gametogenesis1.04171144
49MP0001346_abnormal_lacrimal_gland1.02517721
50MP0005551_abnormal_eye_electrophysiolog1.02342401
51MP0002233_abnormal_nose_morphology0.97326284
52MP0002139_abnormal_hepatobiliary_system0.96290830
53MP0005253_abnormal_eye_physiology0.95136052
54MP0003195_calcinosis0.92324830
55MP0003045_fibrosis0.84544365
56MP0009379_abnormal_foot_pigmentation0.82879292
57MP0005646_abnormal_pituitary_gland0.81403092
58MP0010030_abnormal_orbit_morphology0.80390817
59MP0001970_abnormal_pain_threshold0.78957914
60MP0003879_abnormal_hair_cell0.78846645
61MP0000026_abnormal_inner_ear0.77359156
62MP0000681_abnormal_thyroid_gland0.75761782
63MP0002822_catalepsy0.75012364
64MP0009643_abnormal_urine_homeostasis0.74912993
65MP0001270_distended_abdomen0.73693588
66MP0005165_increased_susceptibility_to0.73568556
67MP0002229_neurodegeneration0.70309111
68MP0003283_abnormal_digestive_organ0.68824912
69MP0000631_abnormal_neuroendocrine_gland0.67099234
70MP0001664_abnormal_digestion0.66742067
71MP0001324_abnormal_eye_pigmentation0.64639378
72MP0005408_hypopigmentation0.63776859
73MP0001963_abnormal_hearing_physiology0.62913732
74MP0002136_abnormal_kidney_physiology0.60482681
75MP0002557_abnormal_social/conspecific_i0.59744800
76MP0005645_abnormal_hypothalamus_physiol0.58939442
77MP0003937_abnormal_limbs/digits/tail_de0.58760713
78MP0008872_abnormal_physiological_respon0.58664303
79MP0001188_hyperpigmentation0.58212944
80MP0001293_anophthalmia0.57472420
81MP0005195_abnormal_posterior_eye0.55839647
82MP0009745_abnormal_behavioral_response0.55835911
83MP0002572_abnormal_emotion/affect_behav0.55161495
84MP0001502_abnormal_circadian_rhythm0.53520646
85MP0000013_abnormal_adipose_tissue0.52964380
86MP0002161_abnormal_fertility/fecundity0.52119252
87MP0003718_maternal_effect0.49997773
88MP0001486_abnormal_startle_reflex0.49438741
89MP0006036_abnormal_mitochondrial_physio0.49065288
90MP0003633_abnormal_nervous_system0.47644870
91MP0000427_abnormal_hair_cycle0.47263385
92MP0002693_abnormal_pancreas_physiology0.46957327
93MP0000049_abnormal_middle_ear0.46908491
94MP0005391_vision/eye_phenotype0.46898286
95MP0003953_abnormal_hormone_level0.46665888
96MP0010155_abnormal_intestine_physiology0.46466721
97MP0002272_abnormal_nervous_system0.45550634
98MP0004885_abnormal_endolymph0.44326567
99MP0001756_abnormal_urination0.44200623
100MP0000955_abnormal_spinal_cord0.44036480

Predicted human phenotypes

RankGene SetZ-score
1Rhinitis (HP:0012384)9.83798654
2Chronic bronchitis (HP:0004469)7.49159097
3Bronchiectasis (HP:0002110)7.22466258
4Nasal polyposis (HP:0100582)6.53363030
5Abnormality of the nasal mucosa (HP:0000433)5.38555929
6Recurrent sinusitis (HP:0011108)4.24374029
7Infertility (HP:0000789)4.18599780
8Bronchitis (HP:0012387)4.10964239
9Chronic sinusitis (HP:0011109)3.87625360
10Occipital encephalocele (HP:0002085)3.86420834
11Pancreatic fibrosis (HP:0100732)3.85528497
12Male infertility (HP:0003251)3.79859508
13True hermaphroditism (HP:0010459)3.77930546
14Recurrent otitis media (HP:0000403)3.63626807
15Pancreatic cysts (HP:0001737)3.28400219
16Molar tooth sign on MRI (HP:0002419)3.18476196
17Abnormality of midbrain morphology (HP:0002418)3.18476196
18Cystic liver disease (HP:0006706)3.16867868
19Nephronophthisis (HP:0000090)3.10301649
20Atelectasis (HP:0100750)2.90497225
21Chronic otitis media (HP:0000389)2.85904558
22Chronic hepatic failure (HP:0100626)2.76702778
23Hyperactive renin-angiotensin system (HP:0000841)2.69792464
24Postaxial foot polydactyly (HP:0001830)2.57278864
25Abnormality of the renal medulla (HP:0100957)2.47197201
26Tubulointerstitial nephritis (HP:0001970)2.36942482
27Congenital hepatic fibrosis (HP:0002612)2.29196080
28Medial flaring of the eyebrow (HP:0010747)2.28109773
29Anencephaly (HP:0002323)2.23743099
30Aplasia/Hypoplasia of the tongue (HP:0010295)2.13891047
31Male pseudohermaphroditism (HP:0000037)2.08653248
32Congenital primary aphakia (HP:0007707)2.05876206
33Sclerocornea (HP:0000647)2.05870093
34Gait imbalance (HP:0002141)2.03259653
35Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.2802876
36Abnormal respiratory epithelium morphology (HP:0012253)11.0855438
37Abnormal respiratory motile cilium morphology (HP:0005938)11.0855438
38Abnormal respiratory motile cilium physiology (HP:0012261)10.8700344
39Dynein arm defect of respiratory motile cilia (HP:0012255)10.8504339
40Absent/shortened dynein arms (HP:0200106)10.8504339
41Abnormal ciliary motility (HP:0012262)10.7714888
42Bell-shaped thorax (HP:0001591)1.90909813
43Tubular atrophy (HP:0000092)1.90877292
44Furrowed tongue (HP:0000221)1.90533935
45Decreased circulating renin level (HP:0003351)1.85189536
46Nephrogenic diabetes insipidus (HP:0009806)1.81087423
47Oculomotor apraxia (HP:0000657)1.79410868
48Recurrent bronchitis (HP:0002837)1.78455275
49Asplenia (HP:0001746)1.76997138
50Aplasia/Hypoplasia of the spleen (HP:0010451)1.76738433
51Renal salt wasting (HP:0000127)1.76582820
52Postaxial hand polydactyly (HP:0001162)1.71239793
53Nephropathy (HP:0000112)1.62946593
54Absent frontal sinuses (HP:0002688)1.60920717
55Hyperkalemia (HP:0002153)1.60326469
56Poor coordination (HP:0002370)1.44581418
57Preaxial hand polydactyly (HP:0001177)1.43988972
58Hyperaldosteronism (HP:0000859)1.42152733
59Tubulointerstitial abnormality (HP:0001969)1.41878714
60Genital tract atresia (HP:0001827)1.41858705
61Vaginal atresia (HP:0000148)1.41548958
62Abnormality of renin-angiotensin system (HP:0000847)1.36574058
63Polydipsia (HP:0001959)1.35920313
64Abnormal drinking behavior (HP:0030082)1.35920313
65Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.33723172
66Stage 5 chronic kidney disease (HP:0003774)1.31961090
67Median cleft lip (HP:0000161)1.29079224
68Absent rod-and cone-mediated responses on ERG (HP:0007688)1.28550778
69Abnormality of chloride homeostasis (HP:0011422)1.25118723
70Short thorax (HP:0010306)1.23635329
71Abnormality of the renal cortex (HP:0011035)1.21976329
72Decreased central vision (HP:0007663)1.18575203
73Retinitis pigmentosa (HP:0000510)1.18167430
74Abnormality of permanent molar morphology (HP:0011071)1.17842639
75Abnormality of the dental root (HP:0006486)1.17842639
76Taurodontia (HP:0000679)1.17842639
77Abnormality of macular pigmentation (HP:0008002)1.15857285
78Hypokalemic alkalosis (HP:0001949)1.12884791
79Bifid scrotum (HP:0000048)1.11832811
80Glucose intolerance (HP:0000833)1.10852499
81Abnormal rod and cone electroretinograms (HP:0008323)1.10397970
82Bile duct proliferation (HP:0001408)1.09504156
83Abnormal biliary tract physiology (HP:0012439)1.09504156
84Hand muscle atrophy (HP:0009130)1.08597278
85Cone-rod dystrophy (HP:0000548)1.08087199
86Abnormality of molar (HP:0011077)1.07477791
87Abnormality of molar morphology (HP:0011070)1.07477791
88Abnormality of the frontal sinuses (HP:0002687)1.07347925
89Hyponatremia (HP:0002902)1.06524786
90Abnormality of the dental pulp (HP:0006479)1.05860630
91Prominent nasal bridge (HP:0000426)1.05569245
92Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.05528912
93Fetal akinesia sequence (HP:0001989)1.04439729
94Tubulointerstitial fibrosis (HP:0005576)1.04046694
95Narrow forehead (HP:0000341)1.03098524
96Aplasia/Hypoplasia of the lens (HP:0008063)1.02641772
97Absent speech (HP:0001344)1.01701081
98Supernumerary spleens (HP:0009799)1.01629855
99Aganglionic megacolon (HP:0002251)1.00656698
100Multicystic kidney dysplasia (HP:0000003)0.99123659

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST45.65841501
2EPHA23.94429761
3PNCK2.23993110
4FRK2.22454784
5MAP3K22.03865803
6NME12.03659496
7MAPKAPK32.02725510
8MAPK1511.5297973
9STK38L1.89110410
10PTK2B1.76988209
11SMG11.74343545
12TTK1.70581365
13STK241.68871707
14LATS11.65694747
15BCR1.27682084
16TLK11.17241739
17STK381.12578382
18PRKD31.07289416
19MAP3K41.05195449
20INSRR1.00610950
21NLK0.99718845
22MAP3K30.98982389
23STK100.97315594
24EEF2K0.97139543
25EPHA30.95874557
26PRKCI0.95823065
27NEK60.95737263
28CSK0.89327940
29STK160.88680408
30ACVR1B0.88503212
31LRRK20.83708192
32TSSK60.83305561
33PINK10.80029071
34BMPR1B0.79755357
35CAMKK10.79108369
36MAP3K70.77185444
37MAP4K20.77070068
38GRK10.75765713
39TRPM70.75181959
40ERBB30.70733948
41BRSK20.68638055
42ADRBK20.67080210
43MST1R0.64514171
44MAP2K70.63800347
45EPHB10.63434239
46CAMKK20.62953030
47PRKAA20.62601003
48MARK20.57773520
49ERBB20.57134256
50TESK10.53665472
51IRAK10.51272235
52FER0.50104629
53WNK30.48364417
54OXSR10.47726378
55ADRBK10.46554926
56TBK10.45269696
57MAP2K20.41525994
58HIPK20.41271460
59MAPKAPK50.40357577
60PRKCQ0.40348487
61PASK0.37110414
62PDPK10.36855569
63CAMK2G0.35720415
64NTRK30.35609054
65WNK40.35526333
66TAOK10.35446875
67AURKA0.34964549
68STK30.33119219
69CASK0.32236604
70PLK10.31095327
71STK390.31069809
72PRKACA0.29767461
73LATS20.29721835
74STK110.29682745
75FGFR20.29644771
76SGK10.29626544
77MAP2K40.28494413
78FGFR30.27576422
79CAMK2A0.27476889
80PRKCD0.26504353
81EPHA40.26351480
82PRKCE0.25983490
83AKT20.25826641
84PBK0.24820879
85RIPK40.24765517
86MAPK130.22133084
87PRKCA0.21766962
88MELK0.21449442
89MAP3K120.20408691
90DYRK1A0.20164073
91PAK30.18955154
92PRKAA10.17569278
93DYRK1B0.17532201
94ABL10.17482618
95ROCK10.17396185
96RPS6KB20.16540224
97CHEK20.15687783
98MAP2K60.14731930
99WEE10.14434655
100CSNK1G20.14066421

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009805.09598640
2Phenylalanine metabolism_Homo sapiens_hsa003604.44243028
3Histidine metabolism_Homo sapiens_hsa003404.24013000
4Chemical carcinogenesis_Homo sapiens_hsa052044.18486643
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.05536594
6Tyrosine metabolism_Homo sapiens_hsa003503.50321906
7beta-Alanine metabolism_Homo sapiens_hsa004103.12307603
8Huntingtons disease_Homo sapiens_hsa050162.81605991
9Glutathione metabolism_Homo sapiens_hsa004802.56030707
10Retinol metabolism_Homo sapiens_hsa008302.18245864
11Linoleic acid metabolism_Homo sapiens_hsa005912.06904791
12Caffeine metabolism_Homo sapiens_hsa002322.03924195
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.01899341
14Sphingolipid metabolism_Homo sapiens_hsa006001.86329873
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.72888560
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.69277428
17Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.67782314
18ABC transporters_Homo sapiens_hsa020101.66969917
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.56967589
20Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.53775390
21Fatty acid degradation_Homo sapiens_hsa000711.42837178
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.40577945
23Peroxisome_Homo sapiens_hsa041461.34865789
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33576513
25Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.33343129
26Tight junction_Homo sapiens_hsa045301.23500182
27Phototransduction_Homo sapiens_hsa047441.15203425
28Butanoate metabolism_Homo sapiens_hsa006501.12914658
29Arachidonic acid metabolism_Homo sapiens_hsa005901.10149870
30Salivary secretion_Homo sapiens_hsa049701.09973654
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.08682479
32Collecting duct acid secretion_Homo sapiens_hsa049661.03484313
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02050253
34Circadian rhythm_Homo sapiens_hsa047100.98550876
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97350846
36Carbohydrate digestion and absorption_Homo sapiens_hsa049730.96640897
37Taste transduction_Homo sapiens_hsa047420.94523688
38Nicotine addiction_Homo sapiens_hsa050330.93050646
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92883054
40Starch and sucrose metabolism_Homo sapiens_hsa005000.83870997
41Hedgehog signaling pathway_Homo sapiens_hsa043400.80469578
42Olfactory transduction_Homo sapiens_hsa047400.79276864
43Tryptophan metabolism_Homo sapiens_hsa003800.77334883
44Pentose and glucuronate interconversions_Homo sapiens_hsa000400.77204036
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68157117
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67635097
47Glycerophospholipid metabolism_Homo sapiens_hsa005640.65000189
48Primary bile acid biosynthesis_Homo sapiens_hsa001200.64815520
49Drug metabolism - other enzymes_Homo sapiens_hsa009830.63422533
50Basal cell carcinoma_Homo sapiens_hsa052170.62546315
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60247091
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57605480
53Nitrogen metabolism_Homo sapiens_hsa009100.56987094
54Metabolic pathways_Homo sapiens_hsa011000.55732817
55Notch signaling pathway_Homo sapiens_hsa043300.54981448
56Insulin secretion_Homo sapiens_hsa049110.54168778
57Serotonergic synapse_Homo sapiens_hsa047260.50362630
58Cocaine addiction_Homo sapiens_hsa050300.47962737
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47498572
60cAMP signaling pathway_Homo sapiens_hsa040240.45232640
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44687272
62Arginine and proline metabolism_Homo sapiens_hsa003300.44539381
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39892807
64Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39084468
65Calcium signaling pathway_Homo sapiens_hsa040200.38306666
66PPAR signaling pathway_Homo sapiens_hsa033200.37229979
67Folate biosynthesis_Homo sapiens_hsa007900.35601850
68Glycerolipid metabolism_Homo sapiens_hsa005610.34920238
69Choline metabolism in cancer_Homo sapiens_hsa052310.34594850
70Vitamin digestion and absorption_Homo sapiens_hsa049770.33206562
71Amphetamine addiction_Homo sapiens_hsa050310.32264973
72Ovarian steroidogenesis_Homo sapiens_hsa049130.31997865
73Propanoate metabolism_Homo sapiens_hsa006400.31702392
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31185605
75Hippo signaling pathway_Homo sapiens_hsa043900.30416954
76Pancreatic secretion_Homo sapiens_hsa049720.30209214
77Oxidative phosphorylation_Homo sapiens_hsa001900.28858905
78Hepatitis C_Homo sapiens_hsa051600.28673501
79Regulation of autophagy_Homo sapiens_hsa041400.27459947
80Fatty acid biosynthesis_Homo sapiens_hsa000610.27002851
81N-Glycan biosynthesis_Homo sapiens_hsa005100.26124687
82Cardiac muscle contraction_Homo sapiens_hsa042600.25507935
83Bile secretion_Homo sapiens_hsa049760.25497528
84Complement and coagulation cascades_Homo sapiens_hsa046100.23671166
85Lysosome_Homo sapiens_hsa041420.23492443
86Adherens junction_Homo sapiens_hsa045200.21486340
87Gastric acid secretion_Homo sapiens_hsa049710.20581705
88Mineral absorption_Homo sapiens_hsa049780.19991484
89Ether lipid metabolism_Homo sapiens_hsa005650.18279030
90Synaptic vesicle cycle_Homo sapiens_hsa047210.18268718
91Protein export_Homo sapiens_hsa030600.18252054
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.17643851
93Vibrio cholerae infection_Homo sapiens_hsa051100.17561707
94Purine metabolism_Homo sapiens_hsa002300.16706844
95Glutamatergic synapse_Homo sapiens_hsa047240.16395683
96Arginine biosynthesis_Homo sapiens_hsa002200.16330638
97Steroid biosynthesis_Homo sapiens_hsa001000.15773108
98Aldosterone synthesis and secretion_Homo sapiens_hsa049250.15341965
99Type I diabetes mellitus_Homo sapiens_hsa049400.13799245
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.13056438

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