CFAP99

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organism reproduction (GO:0032504)9.50949430
2piRNA metabolic process (GO:0034587)9.47147492
3binding of sperm to zona pellucida (GO:0007339)9.40555195
4motile cilium assembly (GO:0044458)9.32996994
5cell-cell recognition (GO:0009988)9.03777711
6spermatid development (GO:0007286)8.75710275
7plasma membrane fusion (GO:0045026)8.74028239
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.73359020
9regulation of cilium movement (GO:0003352)8.57510413
10cell wall macromolecule catabolic process (GO:0016998)8.34645367
11cell wall macromolecule metabolic process (GO:0044036)8.34645367
12male meiosis (GO:0007140)8.11730870
13reproduction (GO:0000003)7.94096506
14synaptonemal complex organization (GO:0070193)7.71920478
15synaptonemal complex assembly (GO:0007130)7.08110754
16single fertilization (GO:0007338)6.75951071
17negative regulation of inclusion body assembly (GO:0090084)6.74974085
18sperm capacitation (GO:0048240)6.43859650
19fertilization (GO:0009566)6.05224038
20DNA methylation involved in gamete generation (GO:0043046)5.99717304
21spermatogenesis (GO:0007283)5.91856908
22male gamete generation (GO:0048232)5.89483562
23male meiosis I (GO:0007141)5.85077219
24axoneme assembly (GO:0035082)5.76772662
25GTP biosynthetic process (GO:0006183)5.74937347
26ventricular system development (GO:0021591)5.71806782
27gamete generation (GO:0007276)5.41688315
28regulation of inclusion body assembly (GO:0090083)5.25281635
29regulation of microtubule-based movement (GO:0060632)5.19877266
30negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)5.18303255
31calcium ion-dependent exocytosis (GO:0017156)5.14550927
32UTP biosynthetic process (GO:0006228)5.10841838
33microtubule severing (GO:0051013)5.08832088
34organic cation transport (GO:0015695)5.07017097
35nucleoside diphosphate phosphorylation (GO:0006165)5.05741890
36germ cell development (GO:0007281)4.99649152
37regulation of vitamin D biosynthetic process (GO:0060556)4.95868634
38cellular process involved in reproduction in multicellular organism (GO:0022412)4.92531284
39chromosome organization involved in meiosis (GO:0070192)4.84808266
40regulation of chronic inflammatory response (GO:0002676)4.77879626
41left/right pattern formation (GO:0060972)4.71891038
42microtubule depolymerization (GO:0007019)4.69233393
43meiosis I (GO:0007127)4.68554186
44UTP metabolic process (GO:0046051)4.66246781
45meiotic nuclear division (GO:0007126)4.64724961
46cell recognition (GO:0008037)4.58048538
47meiotic cell cycle (GO:0051321)4.52438393
48protein polyglutamylation (GO:0018095)4.44891029
49positive regulation of heat generation (GO:0031652)4.39629099
50seminiferous tubule development (GO:0072520)4.35234474
51protein localization to cilium (GO:0061512)4.34809129
52spermatid nucleus differentiation (GO:0007289)4.28675260
53multicellular organismal reproductive process (GO:0048609)4.27850325
54regulation of cytokine secretion involved in immune response (GO:0002739)4.26159710
55regulation of podosome assembly (GO:0071801)4.24503845
56regulation of fever generation (GO:0031620)4.07643354
57regulation of T-helper 1 cell differentiation (GO:0045625)4.02420995
58intraciliary transport (GO:0042073)3.98326005
59regulation of vitamin metabolic process (GO:0030656)3.94887116
60guanosine-containing compound biosynthetic process (GO:1901070)3.92923959
61microtubule-based movement (GO:0007018)3.82012986
62branching involved in labyrinthine layer morphogenesis (GO:0060670)3.79477726
63CTP metabolic process (GO:0046036)3.76673533
64CTP biosynthetic process (GO:0006241)3.76673533
65response to type I interferon (GO:0034340)3.62426666
66regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.60209515
67negative regulation of interleukin-12 production (GO:0032695)3.59777434
68cellular response to type I interferon (GO:0071357)3.59271998
69type I interferon signaling pathway (GO:0060337)3.59271998
70positive regulation of chemokine biosynthetic process (GO:0045080)3.59246778
71genitalia morphogenesis (GO:0035112)3.56293138
72regulation of chemokine biosynthetic process (GO:0045073)3.50915213
73response to peptidoglycan (GO:0032494)3.49597521
74multicellular organismal development (GO:0007275)3.49211169
75cilium organization (GO:0044782)3.48444674
76regulation of germinal center formation (GO:0002634)3.47621936
77positive regulation of tolerance induction (GO:0002645)3.47075004
78pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.42887747
79tolerance induction (GO:0002507)3.41436577
80regulation of membrane protein ectodomain proteolysis (GO:0051043)3.38963822
81negative regulation of amino acid transport (GO:0051956)3.36675223
82chromosome condensation (GO:0030261)3.35152612
83regulation of autophagic vacuole assembly (GO:2000785)3.34555631
84regulation of heat generation (GO:0031650)3.33200709
85negative regulation of organelle assembly (GO:1902116)3.28195185
86cilium assembly (GO:0042384)3.28188514
87adhesion of symbiont to host cell (GO:0044650)3.27849293
88virion attachment to host cell (GO:0019062)3.27849293
89chaperone-mediated protein complex assembly (GO:0051131)3.27839155
90activation of MAPKKK activity (GO:0000185)3.27588277
91gene silencing by RNA (GO:0031047)3.25092092
92germinal center formation (GO:0002467)3.22734855
93hydrogen peroxide biosynthetic process (GO:0050665)3.22141862
94potassium ion export (GO:0071435)3.21035521
95cellular component assembly involved in morphogenesis (GO:0010927)3.20801143
96lipopolysaccharide-mediated signaling pathway (GO:0031663)3.20483026
97pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.19938585
98DNA packaging (GO:0006323)3.18986186
99regulation of meiosis I (GO:0060631)3.18913597
100cilium morphogenesis (GO:0060271)3.18016218
101regulation of mononuclear cell migration (GO:0071675)3.17444507
102glycerol ether metabolic process (GO:0006662)3.15780976
103regulation of chromatin binding (GO:0035561)3.14598033
104left/right axis specification (GO:0070986)3.13137380
105regulation of interferon-alpha production (GO:0032647)3.10046240
106regulation of immunoglobulin secretion (GO:0051023)3.09130217
107positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.08734593
108pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.08228403
109positive regulation of type 2 immune response (GO:0002830)3.07662177
110negative regulation of cytokine production involved in immune response (GO:0002719)3.07439314
111protein refolding (GO:0042026)3.05597340
112regulation of heterotypic cell-cell adhesion (GO:0034114)3.05352517
113primary alcohol catabolic process (GO:0034310)3.04581899
114microtubule bundle formation (GO:0001578)3.03486974
115meiotic cell cycle process (GO:1903046)2.99533223
116regulation of tolerance induction (GO:0002643)2.98895739
117lactate metabolic process (GO:0006089)2.98022451
118ether metabolic process (GO:0018904)2.97948030
119carnitine transport (GO:0015879)2.97134382
120amino-acid betaine transport (GO:0015838)2.97134382
121positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.96894088
122carnitine transmembrane transport (GO:1902603)2.95417363
123peptidyl-glutamic acid modification (GO:0018200)2.93709000
124positive regulation of nitric oxide biosynthetic process (GO:0045429)2.92138364
125regulation of nitric oxide biosynthetic process (GO:0045428)2.90054043
126monoubiquitinated protein deubiquitination (GO:0035520)2.87678737
127negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.87384796
128regulation of T-helper 2 cell differentiation (GO:0045628)2.87364558
129negative regulation of nitric oxide biosynthetic process (GO:0045019)2.85468287
130inflammatory response to antigenic stimulus (GO:0002437)2.83657340
131reactive oxygen species biosynthetic process (GO:1903409)2.79579583
132macrophage activation involved in immune response (GO:0002281)2.79559649
133regulation of vacuole organization (GO:0044088)2.78582880
134response to protozoan (GO:0001562)2.78559447
135regulation of spindle checkpoint (GO:0090231)2.78403749
136alditol metabolic process (GO:0019400)2.77836848
137nucleotide phosphorylation (GO:0046939)2.76602756
138synapsis (GO:0007129)2.76459545
139response to xenobiotic stimulus (GO:0009410)2.75754484
140regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.73315821
141pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.72634991
142monocyte chemotaxis (GO:0002548)2.71842305
143centriole assembly (GO:0098534)2.71369750
144glycolytic process (GO:0006096)2.71347165
145adhesion of symbiont to host (GO:0044406)2.70956408
146myeloid dendritic cell differentiation (GO:0043011)2.70116854
147diterpenoid biosynthetic process (GO:0016102)2.69117140
148regulation of phosphoprotein phosphatase activity (GO:0043666)2.67471732
149polyol catabolic process (GO:0046174)2.67024978
150interferon-gamma-mediated signaling pathway (GO:0060333)2.65807900
151regulation of type 2 immune response (GO:0002828)2.65016183
152negative regulation of viral genome replication (GO:0045071)2.64120303
153immunoglobulin mediated immune response (GO:0016064)2.63490704
154T-helper 1 type immune response (GO:0042088)2.62612435
155natural killer cell mediated cytotoxicity (GO:0042267)2.61344875
156natural killer cell mediated immunity (GO:0002228)2.61344875
157ethanol metabolic process (GO:0006067)2.59006875
158defense response to protozoan (GO:0042832)2.58958385
159regulation of hydrogen peroxide-induced cell death (GO:1903205)2.58843169
160pyrimidine-containing compound transmembrane transport (GO:0072531)2.58192648
161negative regulation of growth of symbiont in host (GO:0044130)2.56921594
162negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.56921594
163modulation of growth of symbiont involved in interaction with host (GO:0044144)2.56921594
164regulation of growth of symbiont in host (GO:0044126)2.56921594
165negative regulation of response to reactive oxygen species (GO:1901032)2.55972459
166nucleus organization (GO:0006997)2.55907064
167tryptophan catabolic process (GO:0006569)2.54885163
168indole-containing compound catabolic process (GO:0042436)2.54885163
169indolalkylamine catabolic process (GO:0046218)2.54885163
170negative regulation of production of molecular mediator of immune response (GO:0002701)2.54818160
171response to acidic pH (GO:0010447)2.52567384
172cilium or flagellum-dependent cell motility (GO:0001539)14.5078487
173sperm motility (GO:0030317)11.8840936
174fusion of sperm to egg plasma membrane (GO:0007342)11.4559689
175axonemal dynein complex assembly (GO:0070286)11.3740354
176acrosome reaction (GO:0007340)10.6169467
177epithelial cilium movement (GO:0003351)10.5205781
178cilium movement (GO:0003341)10.2249623
179sperm-egg recognition (GO:0035036)10.1314509
180acrosome assembly (GO:0001675)10.0733591

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.93111645
2EZH2_22144423_ChIP-Seq_EOC_Human7.36336705
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.65531590
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.26040031
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.98206212
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.33606890
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.32912618
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.27590659
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.26923316
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.15196254
11RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.00900778
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.54817552
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.49031677
14GATA1_26923725_Chip-Seq_HPCs_Mouse2.40759409
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.36740862
16VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.26144035
17IRF8_27001747_Chip-Seq_BMDM_Mouse2.25645994
18ESR2_21235772_ChIP-Seq_MCF-7_Human2.23054559
19ESR1_20079471_ChIP-ChIP_T-47D_Human2.16941698
20VDR_22108803_ChIP-Seq_LS180_Human2.11397544
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.99943860
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.88156690
23EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.86808059
24ELK4_26923725_Chip-Seq_MESODERM_Mouse1.80641639
25ZNF274_21170338_ChIP-Seq_K562_Hela1.77927377
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76588446
27NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.73850878
28IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.73647274
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.73309533
30SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.72203611
31STAT1_20625510_ChIP-Seq_HELA_Human1.72067569
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.70889959
33REST_21632747_ChIP-Seq_MESCs_Mouse1.70785120
34CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.70515426
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.66810999
36LXR_22292898_ChIP-Seq_THP-1_Human1.60584913
37STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.60316119
38MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.59761010
39SMC4_20622854_ChIP-Seq_HELA_Human1.59737926
40FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.59671234
41CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.59483954
42STAT6_21828071_ChIP-Seq_BEAS2B_Human1.57782665
43TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.53397112
44VDR_24787735_ChIP-Seq_THP-1_Human1.52865148
45ESR1_21235772_ChIP-Seq_MCF-7_Human1.51807903
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48599775
47WDR5_24793694_ChIP-Seq_LNCAP_Human1.47827804
48Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.46540611
49STAT4_19710469_ChIP-ChIP_TH1__Mouse1.44429420
50TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.43467843
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41116459
52SPI1_23127762_ChIP-Seq_K562_Human1.41077326
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39022274
54CBP_20019798_ChIP-Seq_JUKART_Human1.39022274
55KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.37820870
56PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35807442
57ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.34502172
58TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33595792
59POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33595792
60SOX2_22085726_ChIP-Seq_NPCs_Mouse1.32740100
61TAF15_26573619_Chip-Seq_HEK293_Human1.32632621
62FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32488821
63GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.32126623
64TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.31486784
65CBX2_27304074_Chip-Seq_ESCs_Mouse1.28944122
66TAL1_26923725_Chip-Seq_HPCs_Mouse1.28668138
67SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.25350083
68ELF1_20517297_ChIP-Seq_JURKAT_Human1.24814756
69KDM2B_26808549_Chip-Seq_SUP-B15_Human1.24213483
70STAT1_17558387_ChIP-Seq_HELA_Human1.23586013
71KDM2B_26808549_Chip-Seq_REH_Human1.23478798
72TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23286966
73SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22754887
74RUNX1_27514584_Chip-Seq_MCF-7_Human1.22433357
75GATA1_19941826_ChIP-Seq_K562_Human1.21540618
76MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.19241264
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.19063399
78AHR_22903824_ChIP-Seq_MCF-7_Human1.18663595
79E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.18103708
80VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17807925
81VDR_24763502_ChIP-Seq_THP-1_Human1.17499911
82FLI1_21867929_ChIP-Seq_TH2_Mouse1.15872236
83PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15696949
84GATA3_21867929_ChIP-Seq_CD8_Mouse1.15137972
85LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.13525493
86RNF2_27304074_Chip-Seq_NSC_Mouse1.13363164
87RAD21_21589869_ChIP-Seq_MESCs_Mouse1.13291355
88STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.12757028
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11850311
90PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11649584
91PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11586535
92RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.10716081
93PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.10519456
94TP63_22573176_ChIP-Seq_HFKS_Human1.09778621
95SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09656734
96GATA3_21867929_ChIP-Seq_TH1_Mouse1.08537614
97GF1_26923725_Chip-Seq_HPCs_Mouse1.08364401
98CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.07800576
99CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06684598
100GATA2_21666600_ChIP-Seq_HMVEC_Human1.05778936
101DROSHA_22980978_ChIP-Seq_HELA_Human1.05517008
102SUZ12_27294783_Chip-Seq_ESCs_Mouse1.05172033
103SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05093299
104KAP1_22055183_ChIP-Seq_ESCs_Mouse1.04913481
105CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04913392
106BCOR_27268052_Chip-Seq_Bcells_Human1.04311386
107SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.02554238
108RACK7_27058665_Chip-Seq_MCF-7_Human1.02135255
109PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01681671
110SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.01145591
111P68_20966046_ChIP-Seq_HELA_Human1.00750251
112SMAD4_21741376_ChIP-Seq_EPCs_Human1.00441967
113FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99687549
114CTCF_27219007_Chip-Seq_Bcells_Human0.99203788
115TP53_18474530_ChIP-ChIP_U2OS_Human0.99081329
116P53_21459846_ChIP-Seq_SAOS-2_Human0.99009517
117FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.98990848
118CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98760933
119CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98369992
120RUNX1_26923725_Chip-Seq_HPCs_Mouse0.98040011
121RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96850192
122BCL6_27268052_Chip-Seq_Bcells_Human0.96679350
123ARNT_22903824_ChIP-Seq_MCF-7_Human0.96366363
124MYC_27129775_Chip-Seq_CORNEA_Mouse0.96338680
125ZFP57_27257070_Chip-Seq_ESCs_Mouse0.95529582
126KDM2B_26808549_Chip-Seq_K562_Human0.95405892
127P63_26484246_Chip-Seq_KERATINOCYTES_Human0.94470125
128CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94410629
129SMAD4_21799915_ChIP-Seq_A2780_Human0.93892002
130NANOG_18555785_Chip-Seq_ESCs_Mouse0.93766342
131KDM2B_26808549_Chip-Seq_DND41_Human0.93340154
132STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.92554577
133CRX_20693478_ChIP-Seq_RETINA_Mouse0.92516951
134OCT4_18555785_Chip-Seq_ESCs_Mouse0.91614391
135SPI1_26923725_Chip-Seq_HPCs_Mouse0.91320904
136EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.91276014
137GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91258551
138SMAD3_21741376_ChIP-Seq_ESCs_Human0.91196833
139EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90923095
140SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90357749
141SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.90188633
142SOX2_20726797_ChIP-Seq_SW620_Human0.89925844
143ZNF263_19887448_ChIP-Seq_K562_Human0.89427223
144P300_27268052_Chip-Seq_Bcells_Human0.88969814
145FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.88305194
146ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.88229276
147TP63_23658742_ChIP-Seq_EP156T_Human0.88216839
148P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.87951839
149ERG_20517297_ChIP-Seq_VCAP_Human0.87611572
150TCF4_23295773_ChIP-Seq_U87_Human0.87551192
151MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87414625
152SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87324029
153PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.87313609
154EZH2_27294783_Chip-Seq_ESCs_Mouse0.86642211
155P53_22387025_ChIP-Seq_ESCs_Mouse0.86578464
156VDR_21846776_ChIP-Seq_THP-1_Human0.86168951
157CTCF_20526341_ChIP-Seq_ESCs_Human0.85610793
158ER_23166858_ChIP-Seq_MCF-7_Human0.85557809
159KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.85552881
160CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.85462148
161SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.85345142
162KLF5_25053715_ChIP-Seq_YYC3_Human0.85260196
163ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.85257026
164RARG_19884340_ChIP-ChIP_MEFs_Mouse0.85220959
165BCAT_22108803_ChIP-Seq_LS180_Human0.85132769
166CTBP1_25329375_ChIP-Seq_LNCAP_Human0.84840393
167RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.84660790
168CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84574591
169RBPJ_22232070_ChIP-Seq_NCS_Mouse0.84463864
170PHF8_20622854_ChIP-Seq_HELA_Human0.83899283
171OCT4_21477851_ChIP-Seq_ESCs_Mouse0.83718593
172CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83712318
173EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.83671923
174SA1_27219007_Chip-Seq_ERYTHROID_Human0.83410905
175RUNX_20019798_ChIP-Seq_JUKART_Human0.82917184
176LXR_22158963_ChIP-Seq_LIVER_Mouse0.82604353
177SOX2_21211035_ChIP-Seq_LN229_Human0.82369446
178YY1_22570637_ChIP-Seq_MALME-3M_Human0.82229904
179EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.81640961
180GF1B_26923725_Chip-Seq_HPCs_Mouse0.81204443
181P300_18555785_Chip-Seq_ESCs_Mouse0.80769035
182ESET_19884257_ChIP-Seq_ESCs_Mouse0.80767192
183MAF_26560356_Chip-Seq_TH1_Human0.80351978
184CMYC_18555785_Chip-Seq_ESCs_Mouse0.80246309
185CREB1_26743006_Chip-Seq_LNCaP_Human0.78197088
186MYB_21317192_ChIP-Seq_ERMYB_Mouse0.77379823
187GATA2_19941826_ChIP-Seq_K562_Human0.76509915
188BRD4_27068464_Chip-Seq_AML-cells_Mouse0.76410640
189KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.75717568
190SMRT_27268052_Chip-Seq_Bcells_Human0.75496875
191PPAR_26484153_Chip-Seq_NCI-H1993_Human0.75457199
192RXR_22158963_ChIP-Seq_LIVER_Mouse0.75219088
193RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.74528412
194OCT4_20526341_ChIP-Seq_ESCs_Human0.74507376

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation6.16584857
2MP0003698_abnormal_male_reproductive5.71703598
3MP0001929_abnormal_gametogenesis5.09986928
4MP0008877_abnormal_DNA_methylation4.28211141
5MP0008004_abnormal_stomach_pH4.11653665
6MP0002653_abnormal_ependyma_morphology3.63140796
7MP0005058_abnormal_lysosome_morphology3.59209788
8MP0006082_CNS_inflammation3.55026792
9MP0002210_abnormal_sex_determination3.36802226
10MP0003724_increased_susceptibility_to3.18629271
11MP0004510_myositis3.13960724
12MP0002161_abnormal_fertility/fecundity3.09298586
13MP0002148_abnormal_hypersensitivity_rea3.01539518
14MP0005670_abnormal_white_adipose3.01325053
15MP0009785_altered_susceptibility_to2.93374386
16MP0005623_abnormal_meninges_morphology2.82096849
17MP0001984_abnormal_olfaction2.81532224
18MP0001145_abnormal_male_reproductive2.81291519
19MP0003436_decreased_susceptibility_to2.69584783
20MP0002139_abnormal_hepatobiliary_system2.56387739
21MP0002132_abnormal_respiratory_system2.43610986
22MP0000653_abnormal_sex_gland2.39883732
23MP0001835_abnormal_antigen_presentation2.33351936
24MP0005387_immune_system_phenotype2.28636244
25MP0001790_abnormal_immune_system2.28636244
26MP0003075_altered_response_to2.23479461
27MP0003453_abnormal_keratinocyte_physiol2.18915287
28MP0005025_abnormal_response_to2.10874246
29MP0009764_decreased_sensitivity_to2.09695166
30MP0002160_abnormal_reproductive_system2.05550736
31MP0008875_abnormal_xenobiotic_pharmacok2.00761172
32MP0005410_abnormal_fertilization14.6016064
33MP0005000_abnormal_immune_tolerance1.96078624
34MP0010155_abnormal_intestine_physiology1.90973189
35MP0003300_gastrointestinal_ulcer1.89224342
36MP0002419_abnormal_innate_immunity1.87596493
37MP0000343_altered_response_to1.87394947
38MP0002332_abnormal_exercise_endurance1.78847662
39MP0004947_skin_inflammation1.75653000
40MP0005671_abnormal_response_to1.74399076
41MP0002277_abnormal_respiratory_mucosa1.73061258
42MP0005451_abnormal_body_composition1.72173964
43MP0009840_abnormal_foam_cell1.72129960
44MP0009046_muscle_twitch1.71636830
45MP0001533_abnormal_skeleton_physiology1.69976396
46MP0003806_abnormal_nucleotide_metabolis1.68607097
47MP0002723_abnormal_immune_serum1.54145420
48MP0001853_heart_inflammation1.51764410
49MP0002452_abnormal_antigen_presenting1.51346661
50MP0005166_decreased_susceptibility_to1.48422500
51MP0003656_abnormal_erythrocyte_physiolo1.46656773
52MP0001845_abnormal_inflammatory_respons1.44823300
53MP0002405_respiratory_system_inflammati1.44678066
54MP0002282_abnormal_trachea_morphology1.40956718
55MP0003646_muscle_fatigue1.38989972
56MP0001800_abnormal_humoral_immune1.38033115
57MP0008469_abnormal_protein_level1.33719070
58MP0004043_abnormal_pH_regulation1.32212815
59MP0002254_reproductive_system_inflammat1.30879248
60MP0005165_increased_susceptibility_to1.29122757
61MP0005164_abnormal_response_to1.27613891
62MP0002998_abnormal_bone_remodeling1.25661161
63MP0005310_abnormal_salivary_gland1.22666618
64MP0003448_altered_tumor_morphology1.18996198
65MP0003172_abnormal_lysosome_physiology1.18654090
66MP0001501_abnormal_sleep_pattern1.16727330
67MP0001819_abnormal_immune_cell1.15381674
68MP0002420_abnormal_adaptive_immunity1.14013189
69MP0003195_calcinosis1.12190310
70MP0008995_early_reproductive_senescence1.08542433
71MP0000858_altered_metastatic_potential1.04410170
72MP0003091_abnormal_cell_migration1.03799176
73MP0004233_abnormal_muscle_weight0.96850939
74MP0005646_abnormal_pituitary_gland0.96516623
75MP0003690_abnormal_glial_cell0.95693723
76MP0002735_abnormal_chemical_nociception0.95306699
77MP0003045_fibrosis0.95282798
78MP0005248_abnormal_Harderian_gland0.93957177
79MP0002168_other_aberrant_phenotype0.93410486
80MP0004883_abnormal_blood_vessel0.93307790
81MP0003011_delayed_dark_adaptation0.92812464
82MP0001765_abnormal_ion_homeostasis0.92806595
83MP0003315_abnormal_perineum_morphology0.92666104
84MP0009763_increased_sensitivity_to0.92531099
85MP0006054_spinal_hemorrhage0.92041831
86MP0009765_abnormal_xenobiotic_induced0.90225141
87MP0005389_reproductive_system_phenotype0.89970977
88MP0003635_abnormal_synaptic_transmissio0.87157931
89MP0000465_gastrointestinal_hemorrhage0.86281397
90MP0002234_abnormal_pharynx_morphology0.83925562
91MP0004859_abnormal_synaptic_plasticity0.83299989
92MP0005647_abnormal_sex_gland0.82876930
93MP0003329_amyloid_beta_deposits0.82620284
94MP0001663_abnormal_digestive_system0.78826877
95MP0005394_taste/olfaction_phenotype0.78073179
96MP0005499_abnormal_olfactory_system0.78073179
97MP0004270_analgesia0.77713527
98MP0004811_abnormal_neuron_physiology0.77205344
99MP0005551_abnormal_eye_electrophysiolog0.76822967
100MP0005023_abnormal_wound_healing0.74955418
101MP0005423_abnormal_somatic_nervous0.74876469
102MP0000685_abnormal_immune_system0.74639495
103MP0001542_abnormal_bone_strength0.73945736
104MP0001440_abnormal_grooming_behavior0.73907880
105MP0001968_abnormal_touch/_nociception0.73795394
106MP0002572_abnormal_emotion/affect_behav0.72486871
107MP0000716_abnormal_immune_system0.71714593
108MP0005390_skeleton_phenotype0.71524641
109MP0002272_abnormal_nervous_system0.71164244
110MP0000678_abnormal_parathyroid_gland0.70818702
111MP0003879_abnormal_hair_cell0.69458999
112MP0009333_abnormal_splenocyte_physiolog0.69158290
113MP0008789_abnormal_olfactory_epithelium0.68654953
114MP0001486_abnormal_startle_reflex0.67706434
115MP0005666_abnormal_adipose_tissue0.67506832
116MP0002909_abnormal_adrenal_gland0.66720587
117MP0003880_abnormal_central_pattern0.65426381
118MP0002063_abnormal_learning/memory/cond0.64959207
119MP0003115_abnormal_respiratory_system0.64832950
120MP0008874_decreased_physiological_sensi0.64200194
121MP0008057_abnormal_DNA_replication0.64025391
122MP0003633_abnormal_nervous_system0.62217217
123MP0005253_abnormal_eye_physiology0.62077150
124MP0009745_abnormal_behavioral_response0.61952031
125MP0002557_abnormal_social/conspecific_i0.61926860
126MP0005377_hearing/vestibular/ear_phenot0.61417085
127MP0003878_abnormal_ear_physiology0.61417085
128MP0001727_abnormal_embryo_implantation0.60699052
129MP0000920_abnormal_myelination0.58969226
130MP0002734_abnormal_mechanical_nocicepti0.58332333
131MP0002152_abnormal_brain_morphology0.58156436
132MP0008569_lethality_at_weaning0.57640470
133MP0000751_myopathy0.56246873
134MP0005397_hematopoietic_system_phenotyp0.55858886
135MP0001545_abnormal_hematopoietic_system0.55858886
136MP0004019_abnormal_vitamin_homeostasis0.55127722
137MP0005595_abnormal_vascular_smooth0.54841264
138MP0001664_abnormal_digestion0.54486354
139MP0003191_abnormal_cellular_cholesterol0.53991600
140MP0002064_seizures0.53801910
141MP0001849_ear_inflammation0.53767013
142MP0001919_abnormal_reproductive_system0.52197687
143MP0002136_abnormal_kidney_physiology0.51662289
144MP0009115_abnormal_fat_cell0.50388476
145MP0002971_abnormal_brown_adipose0.50272245
146MP0003634_abnormal_glial_cell0.49988099
147MP0009278_abnormal_bone_marrow0.49912626
148MP0002882_abnormal_neuron_morphology0.47950534
149MP0001293_anophthalmia0.47199532
150MP0003861_abnormal_nervous_system0.45954102
151MP0003631_nervous_system_phenotype0.45526466
152MP0002229_neurodegeneration0.45277260
153MP0004134_abnormal_chest_morphology0.44707774
154MP0002736_abnormal_nociception_after0.44416054
155MP0000778_abnormal_nervous_system0.44308966
156MP0002067_abnormal_sensory_capabilities0.44106414
157MP0003786_premature_aging0.42662937
158MP0005167_abnormal_blood-brain_barrier0.41584476
159MP0005391_vision/eye_phenotype0.41221055
160MP0002184_abnormal_innervation0.40616634
161MP0006072_abnormal_retinal_apoptosis0.40482728
162MP0000534_abnormal_ureter_morphology0.40227971
163MP0008058_abnormal_DNA_repair0.39594654
164MP0008961_abnormal_basal_metabolism0.38760981
165MP0002752_abnormal_somatic_nervous0.38680750
166MP0000955_abnormal_spinal_cord0.37990596
167MP0002822_catalepsy0.37965615
168MP0000604_amyloidosis0.37775597
169MP0004742_abnormal_vestibular_system0.36749038
170MP0004858_abnormal_nervous_system0.33942600
171MP0004133_heterotaxia0.33670825
172MP0002928_abnormal_bile_duct0.33015814
173MP0003699_abnormal_female_reproductive0.32505645
174MP0002066_abnormal_motor_capabilities/c0.31810847
175MP0001324_abnormal_eye_pigmentation0.31780361
176MP0001970_abnormal_pain_threshold0.31578840
177MP0002269_muscular_atrophy0.31502794
178MP0001270_distended_abdomen0.30263289
179MP0000358_abnormal_cell_content/0.29780132
180MP0002733_abnormal_thermal_nociception0.29359726
181MP0002295_abnormal_pulmonary_circulatio0.28981909

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)9.61548607
2Abnormal respiratory epithelium morphology (HP:0012253)9.61548607
3Abnormal ciliary motility (HP:0012262)9.08455626
4Rhinitis (HP:0012384)8.30255724
5Chronic bronchitis (HP:0004469)6.81073188
6Nasal polyposis (HP:0100582)5.82140932
7Infertility (HP:0000789)5.78706809
8Abnormality of the nasal mucosa (HP:0000433)4.80870106
9Bronchiectasis (HP:0002110)4.79781531
10Nephronophthisis (HP:0000090)4.61620361
11Bronchitis (HP:0012387)4.11435466
12Recurrent sinusitis (HP:0011108)3.78159977
13Abnormality of glycolipid metabolism (HP:0010969)3.70572854
14Abnormality of liposaccharide metabolism (HP:0010968)3.70572854
15Abnormality of glycosphingolipid metabolism (HP:0004343)3.70572854
16Abnormality of the renal medulla (HP:0100957)3.54357268
17Abnormality of the lower motor neuron (HP:0002366)3.13941236
18Tubular atrophy (HP:0000092)3.11405463
19Recurrent otitis media (HP:0000403)3.10996028
20Chronic otitis media (HP:0000389)2.98279857
21Male infertility (HP:0003251)2.95872186
22Optic neuritis (HP:0100653)2.88172403
23Retrobulbar optic neuritis (HP:0100654)2.88172403
24Tubulointerstitial nephritis (HP:0001970)2.82971805
25Nuclear cataract (HP:0100018)2.79676091
26Gonadotropin excess (HP:0000837)2.73883972
27Orchitis (HP:0100796)2.69673853
28Occipital encephalocele (HP:0002085)2.64922177
29Molar tooth sign on MRI (HP:0002419)2.56878258
30Abnormality of midbrain morphology (HP:0002418)2.56878258
31Myositis (HP:0100614)2.53786420
32Tubulointerstitial abnormality (HP:0001969)2.49152765
33Atelectasis (HP:0100750)2.48271108
34Disinhibition (HP:0000734)2.46038748
35Systemic lupus erythematosus (HP:0002725)2.42792054
36Amyotrophic lateral sclerosis (HP:0007354)2.39501855
37Loss of speech (HP:0002371)2.36516907
38Medial flaring of the eyebrow (HP:0010747)2.36471430
39Abnormal spermatogenesis (HP:0008669)2.34738618
40Recurrent bronchitis (HP:0002837)2.31676985
41Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.27084006
42Autoimmune thrombocytopenia (HP:0001973)2.19319888
43Dysostosis multiplex (HP:0000943)2.16740629
44Fibular hypoplasia (HP:0003038)2.13659962
45Stomatitis (HP:0010280)2.12964422
46Stage 5 chronic kidney disease (HP:0003774)2.10844810
47Tubulointerstitial fibrosis (HP:0005576)2.09867246
48Chronic hepatic failure (HP:0100626)2.07173566
49Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.06394444
50Congenital hepatic fibrosis (HP:0002612)2.03342668
51Vacuolated lymphocytes (HP:0001922)2.03105290
52Abnormality of the renal cortex (HP:0011035)2.02546237
53Increased cerebral lipofuscin (HP:0011813)2.00515030
54Abnormal drinking behavior (HP:0030082)2.00397745
55Polydipsia (HP:0001959)2.00397745
56Interstitial pulmonary disease (HP:0006530)2.00237124
57Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.9865894
58Dynein arm defect of respiratory motile cilia (HP:0012255)12.7068699
59Absent/shortened dynein arms (HP:0200106)12.7068699
60Abnormal respiratory motile cilium physiology (HP:0012261)10.4747764
61Postaxial foot polydactyly (HP:0001830)1.98331929
62Ventricular fibrillation (HP:0001663)1.90876579
63Axonal loss (HP:0003447)1.88978480
64Upper motor neuron abnormality (HP:0002127)1.88308787
65Recurrent bacterial skin infections (HP:0005406)1.85209497
66Impaired proprioception (HP:0010831)1.85109350
67Glomerulonephritis (HP:0000099)1.84975412
68Abnormality of macrophages (HP:0004311)1.83427030
69Male pseudohermaphroditism (HP:0000037)1.83298329
70Retinal dysplasia (HP:0007973)1.82396504
71Hyperactive renin-angiotensin system (HP:0000841)1.81282324
72Keratoconjunctivitis sicca (HP:0001097)1.80918149
73Chronic sinusitis (HP:0011109)1.80030734
74Mutism (HP:0002300)1.79949219
75Supernumerary spleens (HP:0009799)1.79351145
76Impulsivity (HP:0100710)1.78348884
77Thoracic kyphosis (HP:0002942)1.78063704
78Abnormality of polysaccharide metabolism (HP:0011012)1.76373264
79Abnormality of glycosaminoglycan metabolism (HP:0004371)1.76373264
80Abnormality of mucopolysaccharide metabolism (HP:0011020)1.76373264
81Oculomotor apraxia (HP:0000657)1.74389059
82Abnormality of dentin (HP:0010299)1.74320005
83Short ribs (HP:0000773)1.72863692
84Facial cleft (HP:0002006)1.72672434
85Hypoplasia of the capital femoral epiphysis (HP:0003090)1.71106984
86Urinary glycosaminoglycan excretion (HP:0003541)1.70339525
87Mucopolysacchariduria (HP:0008155)1.70339525
88Spastic tetraparesis (HP:0001285)1.69206998
89Colitis (HP:0002583)1.68944232
90Postaxial hand polydactyly (HP:0001162)1.68009750
91Abnormality of the frontal sinuses (HP:0002687)1.66856581
92Basal ganglia calcification (HP:0002135)1.66852452
93Pancreatic fibrosis (HP:0100732)1.66522469
94Azoospermia (HP:0000027)1.66419467
95Renal dysplasia (HP:0000110)1.65347402
96Polyneuropathy (HP:0001271)1.63867109
97Recurrent abscess formation (HP:0002722)1.63028476
98Gangrene (HP:0100758)1.60863774
99Keratoconjunctivitis (HP:0001096)1.60767783
100Abnormal biliary tract physiology (HP:0012439)1.60590910
101Bile duct proliferation (HP:0001408)1.60590910
102Abnormality of the dental root (HP:0006486)1.57419848
103Taurodontia (HP:0000679)1.57419848
104Abnormality of permanent molar morphology (HP:0011071)1.57419848
105Absent rod-and cone-mediated responses on ERG (HP:0007688)1.56560497
106Malnutrition (HP:0004395)1.56115819
107Increased serum ferritin (HP:0003281)1.54539424
108Broad distal phalanx of finger (HP:0009836)1.53864986
109J-shaped sella turcica (HP:0002680)1.52424840
110Apathy (HP:0000741)1.52182184
111Gait imbalance (HP:0002141)1.52112097
112Heterotopia (HP:0002282)1.51289902
113Thoracolumbar scoliosis (HP:0002944)1.51080472
114Congenital primary aphakia (HP:0007707)1.49901068
115Complement deficiency (HP:0004431)1.49480543
116Purpura (HP:0000979)1.49395962
117Anencephaly (HP:0002323)1.48806625
118Abnormality of renal excretion (HP:0011036)1.48518939
119Recurrent gram-negative bacterial infections (HP:0005420)1.48421648
120Abnormal gallbladder physiology (HP:0012438)1.48342409
121Cholecystitis (HP:0001082)1.48342409
122Cystic liver disease (HP:0006706)1.48216715
123Degeneration of anterior horn cells (HP:0002398)1.47987811
124Abnormality of the anterior horn cell (HP:0006802)1.47987811
125Bell-shaped thorax (HP:0001591)1.47844904
126Absent frontal sinuses (HP:0002688)1.47564462
127Median cleft lip (HP:0000161)1.46409895
128Neurofibrillary tangles (HP:0002185)1.44763697
129Increased neuronal autofluorescent lipopigment (HP:0002074)1.44541262
130Abnormality of molar morphology (HP:0011070)1.44206151
131Abnormality of molar (HP:0011077)1.44206151
132Parakeratosis (HP:0001036)1.43987981
133Abnormality of the dental pulp (HP:0006479)1.43933851
134Pancreatic cysts (HP:0001737)1.43740751
135Mediastinal lymphadenopathy (HP:0100721)1.43135678
136Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.43060494
137Abnormality of ocular smooth pursuit (HP:0000617)1.42166988
138Microglossia (HP:0000171)1.40501454
139Dyschromatopsia (HP:0007641)1.39121382
140Choroideremia (HP:0001139)1.38300663
141Diminished motivation (HP:0000745)1.37517516
142Abnormality of the lumbar spine (HP:0100712)1.35534719
143Short thorax (HP:0010306)1.35510117
144True hermaphroditism (HP:0010459)1.34700889
145Aplasia/Hypoplasia of the lens (HP:0008063)1.34651780
146Absent epiphyses (HP:0010577)1.33062794
147Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.33062794
148Diaphragmatic weakness (HP:0009113)1.32727071
149Aplasia/Hypoplasia of the tongue (HP:0010295)1.32500002
150Metaphyseal irregularity (HP:0003025)1.32336580
151Nephrogenic diabetes insipidus (HP:0009806)1.31131366
152Eczematoid dermatitis (HP:0000976)1.30799580
153Abnormal urine output (HP:0012590)1.29392556
154Resting tremor (HP:0002322)1.27777664
155Elevated erythrocyte sedimentation rate (HP:0003565)1.27641975
156Arterial thrombosis (HP:0004420)1.27598492
157Inappropriate behavior (HP:0000719)1.27176827
158Dementia (HP:0000726)1.27154568
159Abnormality of monocarboxylic acid metabolism (HP:0010996)1.27099772
160Aplasia/Hypoplasia of the fibula (HP:0006492)1.24795904
161Nephropathy (HP:0000112)1.21500826
162Polyuria (HP:0000103)1.20760378
163Deformed sella turcica (HP:0002681)1.20485122
16411 pairs of ribs (HP:0000878)1.19960877
165Decreased motor nerve conduction velocity (HP:0003431)1.17566983
166Cerebral inclusion bodies (HP:0100314)1.17322878
167Severe visual impairment (HP:0001141)1.14682131
168Gaze-evoked nystagmus (HP:0000640)1.14029269
169Vaginal atresia (HP:0000148)1.13986049

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.28482534
2PDK38.28482534
3PDK25.32003598
4TESK15.28739955
5PRKD34.66687178
6IRAK33.79218379
7ICK3.37756950
8NME23.06764557
9MARK32.99861670
10RIPK12.88427356
11GRK72.84212572
12TBK12.68875836
13PNCK2.66361979
14PTK2B2.64729273
15TAOK22.61664604
16MAP3K32.43869329
17DDR22.20152075
18WNK42.19677469
19MAP3K142.19107343
20STK392.18999918
21TLK12.13881792
22PIM22.12825417
23MOS1.88524412
24STK381.81992093
25CDC42BPA1.77528639
26CSK1.74236956
27NEK21.73307663
28IKBKE1.64884072
29MATK1.63474731
30MST41.62141633
31MAP3K111.51916063
32LATS21.51242282
33IKBKB1.45629186
34FGR1.41128968
35ADRBK21.27486702
36TYK21.26548394
37IRAK41.25776653
38EPHA21.25351357
39MAPK151.20726800
40WNK11.18144803
41MAP3K51.17958925
42BMPR21.12488240
43MYLK1.09576328
44DYRK1B1.08299637
45CHUK1.04391331
46PDK10.96559135
47TGFBR20.95201373
48CCNB10.94250376
49STK100.91443720
50CAMK1G0.90045233
51RPS6KA50.85578050
52DYRK30.84807240
53STK240.84392696
54TXK0.83268828
55CLK10.83158749
56TYRO30.82570251
57PRPF4B0.82473099
58ABL20.81304852
59MAP3K130.77782418
60EPHB10.76326576
61ARAF0.75969372
62PKN10.74250898
63LMTK20.73227523
64MAP2K30.72947714
65MAP4K10.72619360
66IRAK10.71868334
67MKNK20.71449738
68TTK0.68117291
69CDC70.65455113
70PINK10.63102046
71NTRK20.63087240
72CAMKK10.62449084
73JAK30.60819402
74LATS10.58563892
75TRIB30.58197825
76MST1R0.57496750
77ZAP700.57144640
78STK30.56856505
79JAK20.56561819
80EEF2K0.56418227
81IRAK20.55785247
82HIPK20.53642406
83PASK0.53161167
84LYN0.51201553
85PAK60.50452763
86BMPR1B0.49885566
87PDPK10.49298429
88EGFR0.48880533
89EPHA30.48031017
90BTK0.46207886
91MINK10.45572614
92RIPK40.45173689
93DAPK30.43671223
94PRKCG0.43481308
95MAPKAPK50.41864620
96ERN10.41800424
97ACVR1B0.41223571
98PIM10.39786277
99JAK10.34236621
100MARK20.32552764
101MAP2K70.32097307
102MAPKAPK30.31413594
103MUSK0.30867333
104DAPK20.30573754
105MAP3K40.29168724
106MAP2K60.28321314
107CDK60.28132447
108MARK10.27767633
109MELK0.27691278
110PAK20.27434498
111STK110.27327334
112MAP3K90.27314660
113SCYL20.26993892
114MAP3K100.26291168
115CHEK10.26114848
116SIK20.24471791
117CHEK20.23465756
118SMG10.22898286
119PRKAA10.22540736
120EPHA40.21683717
121PAK10.21259561
122ATM0.20855687
123ATR0.20504478
124CAMK2A0.20258924
125SGK2230.19849734
126SGK4940.19849734
127LCK0.19473084
128PRKCD0.18734300
129HCK0.18551610
130FRK0.18254532
131CDK150.18143154
132FES0.17952277
133ABL10.17933037
134MTOR0.17770149
135CAMKK20.16923369
136TRPM70.16479178
137CDK180.16019318
138MAPK40.15663233
139SYK0.15627017
140DYRK1A0.15451466
141PHKG20.14473965
142PHKG10.14473965
143WEE10.14250451
144CDK11A0.14008182
145RPS6KB10.13768433
146CDK140.12888505
147PRKCZ0.12148144
148BLK0.12038986
149CDK50.11518742
150MAP3K20.10995797
151CASK0.10606246
152NTRK30.10306214
153PRKG10.10004834
154PRKCQ0.09680328
155CAMK2G0.09143856
156CAMK10.09134873
157PAK40.08362439
158MAPK100.08105669
159PRKACG0.07907843
160FGFR20.07857831
161GRK50.06734735
162CSNK1D0.06620954
163GSK3B0.06331285
164PRKACB0.06201913
165RPS6KA30.05789098
166MAP3K10.05413947
167AURKA0.04186747
168MKNK10.03452274
169TAOK10.03309662
170RPS6KA20.03155152
171CSNK1E0.02697383
172PRKACA0.02483290

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007503.73179422
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.43643769
3Fatty acid biosynthesis_Homo sapiens_hsa000613.43635757
4Pyruvate metabolism_Homo sapiens_hsa006203.30167527
5Dorso-ventral axis formation_Homo sapiens_hsa043202.88937147
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.83072538
7Glucagon signaling pathway_Homo sapiens_hsa049222.61128485
8Propanoate metabolism_Homo sapiens_hsa006402.58165019
9Rheumatoid arthritis_Homo sapiens_hsa053232.40259200
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.39697718
11RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.39470391
12Asthma_Homo sapiens_hsa053102.37762023
13Malaria_Homo sapiens_hsa051442.37592255
14Allograft rejection_Homo sapiens_hsa053302.34149688
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.30026352
16Other glycan degradation_Homo sapiens_hsa005112.27618139
17TNF signaling pathway_Homo sapiens_hsa046682.23108017
18Amphetamine addiction_Homo sapiens_hsa050312.21363815
19Olfactory transduction_Homo sapiens_hsa047402.09614799
20Osteoclast differentiation_Homo sapiens_hsa043802.08675392
21NOD-like receptor signaling pathway_Homo sapiens_hsa046212.05297655
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.01617224
23Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.95385176
24Oocyte meiosis_Homo sapiens_hsa041141.94746469
25Staphylococcus aureus infection_Homo sapiens_hsa051501.94629124
26Linoleic acid metabolism_Homo sapiens_hsa005911.93961470
27Lysosome_Homo sapiens_hsa041421.93541890
28Pertussis_Homo sapiens_hsa051331.93448519
29African trypanosomiasis_Homo sapiens_hsa051431.86954398
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.85038877
31Graft-versus-host disease_Homo sapiens_hsa053321.83819237
32Renin secretion_Homo sapiens_hsa049241.81246739
33Huntingtons disease_Homo sapiens_hsa050161.79600565
34Leishmaniasis_Homo sapiens_hsa051401.79054300
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.78981535
36Phenylalanine metabolism_Homo sapiens_hsa003601.75784665
37Carbohydrate digestion and absorption_Homo sapiens_hsa049731.72293491
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.72136758
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.71687017
40Phagosome_Homo sapiens_hsa041451.68569875
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.67722353
42Glycerolipid metabolism_Homo sapiens_hsa005611.66692766
43Long-term potentiation_Homo sapiens_hsa047201.66197406
44Autoimmune thyroid disease_Homo sapiens_hsa053201.64936885
45Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.63255018
46Influenza A_Homo sapiens_hsa051641.59863126
47Salmonella infection_Homo sapiens_hsa051321.58584555
48Tuberculosis_Homo sapiens_hsa051521.57902175
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.57084655
50Synaptic vesicle cycle_Homo sapiens_hsa047211.56348601
51Apoptosis_Homo sapiens_hsa042101.55537378
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.54310317
53Basal transcription factors_Homo sapiens_hsa030221.52012368
54Cardiac muscle contraction_Homo sapiens_hsa042601.49236015
55Sphingolipid metabolism_Homo sapiens_hsa006001.48617809
56Insulin secretion_Homo sapiens_hsa049111.47320474
57PPAR signaling pathway_Homo sapiens_hsa033201.47094770
58Selenocompound metabolism_Homo sapiens_hsa004501.46712873
59Circadian entrainment_Homo sapiens_hsa047131.44332184
60Hepatitis C_Homo sapiens_hsa051601.40956973
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.39890322
62Type I diabetes mellitus_Homo sapiens_hsa049401.36090304
63Taste transduction_Homo sapiens_hsa047421.30508200
64Jak-STAT signaling pathway_Homo sapiens_hsa046301.28034001
65Estrogen signaling pathway_Homo sapiens_hsa049151.27843029
66Toxoplasmosis_Homo sapiens_hsa051451.27238171
67Pentose phosphate pathway_Homo sapiens_hsa000301.26827079
68Hematopoietic cell lineage_Homo sapiens_hsa046401.25376890
69Glycerophospholipid metabolism_Homo sapiens_hsa005641.23402228
70Salivary secretion_Homo sapiens_hsa049701.17985985
71Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.16284947
72Fructose and mannose metabolism_Homo sapiens_hsa000511.15936500
73Histidine metabolism_Homo sapiens_hsa003401.15122879
74Herpes simplex infection_Homo sapiens_hsa051681.14755542
75Prion diseases_Homo sapiens_hsa050201.14133791
76Glutamatergic synapse_Homo sapiens_hsa047241.12622036
77Calcium signaling pathway_Homo sapiens_hsa040201.12375689
78Fanconi anemia pathway_Homo sapiens_hsa034601.08150050
79Gastric acid secretion_Homo sapiens_hsa049711.06847148
80Ether lipid metabolism_Homo sapiens_hsa005651.06183666
81Morphine addiction_Homo sapiens_hsa050321.05611603
82Tyrosine metabolism_Homo sapiens_hsa003501.02231808
83cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00070041
84Measles_Homo sapiens_hsa051620.99968324
85Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.98444729
86Bile secretion_Homo sapiens_hsa049760.97776693
87Gap junction_Homo sapiens_hsa045400.97043709
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95911461
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.95389886
90Collecting duct acid secretion_Homo sapiens_hsa049660.94618670
91Nicotine addiction_Homo sapiens_hsa050330.92627145
92Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.91674867
93Thyroid hormone synthesis_Homo sapiens_hsa049180.89497554
94Aldosterone synthesis and secretion_Homo sapiens_hsa049250.88502688
95Hedgehog signaling pathway_Homo sapiens_hsa043400.87610142
96Amoebiasis_Homo sapiens_hsa051460.87041506
97Carbon metabolism_Homo sapiens_hsa012000.86404443
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85111904
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84916425
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.84896172
101Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.84696479
102Dopaminergic synapse_Homo sapiens_hsa047280.82742999
103ABC transporters_Homo sapiens_hsa020100.80603694
104cAMP signaling pathway_Homo sapiens_hsa040240.80037623
105Mineral absorption_Homo sapiens_hsa049780.79795062
106Arachidonic acid metabolism_Homo sapiens_hsa005900.77361700
107beta-Alanine metabolism_Homo sapiens_hsa004100.75836539
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75314025
109mRNA surveillance pathway_Homo sapiens_hsa030150.75096347
110Phototransduction_Homo sapiens_hsa047440.73706107
111Hepatitis B_Homo sapiens_hsa051610.72916761
112Oxytocin signaling pathway_Homo sapiens_hsa049210.72044641
113Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71848035
114Nitrogen metabolism_Homo sapiens_hsa009100.71704983
115B cell receptor signaling pathway_Homo sapiens_hsa046620.71628451
116Purine metabolism_Homo sapiens_hsa002300.70477895
117Complement and coagulation cascades_Homo sapiens_hsa046100.70328016
118Chemokine signaling pathway_Homo sapiens_hsa040620.69789496
119Alcoholism_Homo sapiens_hsa050340.69319945
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69134722
121Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69055538
122Type II diabetes mellitus_Homo sapiens_hsa049300.68933505
123Fat digestion and absorption_Homo sapiens_hsa049750.68338785
124Cocaine addiction_Homo sapiens_hsa050300.66657128
125Pancreatic secretion_Homo sapiens_hsa049720.66147307
126Viral myocarditis_Homo sapiens_hsa054160.65583174
127Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65280565
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.63798191
129Fatty acid metabolism_Homo sapiens_hsa012120.62200289
130Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62104900
131Sphingolipid signaling pathway_Homo sapiens_hsa040710.61996075
132Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.61548471
133Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61089029
134Endocytosis_Homo sapiens_hsa041440.59415348
135Adipocytokine signaling pathway_Homo sapiens_hsa049200.58977871
136GABAergic synapse_Homo sapiens_hsa047270.58939289
137T cell receptor signaling pathway_Homo sapiens_hsa046600.58361085
138Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58115110
139VEGF signaling pathway_Homo sapiens_hsa043700.57560796
140Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57289013
141Glycosaminoglycan degradation_Homo sapiens_hsa005310.57017873
142Central carbon metabolism in cancer_Homo sapiens_hsa052300.54397791
143Fatty acid degradation_Homo sapiens_hsa000710.52261446
144AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52055927
145Glutathione metabolism_Homo sapiens_hsa004800.51536764
146Systemic lupus erythematosus_Homo sapiens_hsa053220.51106893
147Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50616229
148Prolactin signaling pathway_Homo sapiens_hsa049170.49872465
149Bladder cancer_Homo sapiens_hsa052190.49288295
150Antigen processing and presentation_Homo sapiens_hsa046120.48254980
151Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47315475
152Acute myeloid leukemia_Homo sapiens_hsa052210.46181881
153AMPK signaling pathway_Homo sapiens_hsa041520.45048059
154Tryptophan metabolism_Homo sapiens_hsa003800.44982256
155Steroid hormone biosynthesis_Homo sapiens_hsa001400.43691818
156Chemical carcinogenesis_Homo sapiens_hsa052040.43602919
157SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41685336
158Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40398874
159Inositol phosphate metabolism_Homo sapiens_hsa005620.38820707
160RNA transport_Homo sapiens_hsa030130.38456521
161Cholinergic synapse_Homo sapiens_hsa047250.38008790
162Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.37858162
163Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.36448007
164Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36444332
165Shigellosis_Homo sapiens_hsa051310.36345079
166Legionellosis_Homo sapiens_hsa051340.34628266
167Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34571947
168Basal cell carcinoma_Homo sapiens_hsa052170.31250277
169Melanogenesis_Homo sapiens_hsa049160.31141001
170Insulin resistance_Homo sapiens_hsa049310.31081435
171Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30455513
172Notch signaling pathway_Homo sapiens_hsa043300.30288700
173Leukocyte transendothelial migration_Homo sapiens_hsa046700.26847562
174Epstein-Barr virus infection_Homo sapiens_hsa051690.26755645
175Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.20686171
176MAPK signaling pathway_Homo sapiens_hsa040100.16701746
177HTLV-I infection_Homo sapiens_hsa051660.16362200

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