CFC1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1endocrine pancreas development (GO:0031018)5.11251444
2regulation of type B pancreatic cell apoptotic process (GO:2000674)4.79169995
3insulin secretion (GO:0030073)4.29251010
4negative regulation of cytosolic calcium ion concentration (GO:0051481)4.18955446
5peptide hormone processing (GO:0016486)4.16266827
6water-soluble vitamin biosynthetic process (GO:0042364)4.10445706
7cellular ketone body metabolic process (GO:0046950)4.10225162
8negative regulation of hormone biosynthetic process (GO:0032353)4.06232718
9dendritic spine morphogenesis (GO:0060997)4.03516146
10regulation of hexokinase activity (GO:1903299)4.00469412
11regulation of glucokinase activity (GO:0033131)4.00469412
12nodal signaling pathway (GO:0038092)3.93177170
13epithelial cell fate commitment (GO:0072148)3.92227203
14positive regulation of insulin secretion (GO:0032024)3.88361495
15neuron fate determination (GO:0048664)3.85742897
16negative regulation of execution phase of apoptosis (GO:1900118)3.84361952
17glycerophospholipid catabolic process (GO:0046475)3.80589617
18inositol phosphate catabolic process (GO:0071545)3.80258237
19protein localization to cilium (GO:0061512)3.73716570
20L-alpha-amino acid transmembrane transport (GO:1902475)3.72158505
21regulation of neurotransmitter uptake (GO:0051580)3.71243636
22glandular epithelial cell differentiation (GO:0002067)3.71205421
23nitric oxide mediated signal transduction (GO:0007263)3.68451842
24positive regulation of glycolytic process (GO:0045821)3.67633555
25respiratory chain complex IV assembly (GO:0008535)3.64488529
26positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.63071094
27ketone body metabolic process (GO:1902224)3.62253292
28regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.59467753
29regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.59467753
30detection of calcium ion (GO:0005513)3.49141081
31positive regulation of peptide hormone secretion (GO:0090277)3.45161129
32negative regulation of hormone metabolic process (GO:0032351)3.44000718
33phosphorylated carbohydrate dephosphorylation (GO:0046838)3.40628426
34inositol phosphate dephosphorylation (GO:0046855)3.40628426
35positive regulation of peptide secretion (GO:0002793)3.31421573
36toxin transport (GO:1901998)3.30209334
37regulation of insulin secretion (GO:0050796)3.28766099
38polyol catabolic process (GO:0046174)3.20630055
39nephron epithelium morphogenesis (GO:0072088)3.19129377
40nephron tubule morphogenesis (GO:0072078)3.19129377
41signal peptide processing (GO:0006465)3.17176145
42auditory receptor cell differentiation (GO:0042491)3.14387660
43lactate metabolic process (GO:0006089)3.13294112
44dopamine transport (GO:0015872)3.10504488
45positive regulation of gluconeogenesis (GO:0045722)3.09959800
46cytochrome complex assembly (GO:0017004)3.06801006
47type B pancreatic cell development (GO:0003323)3.06629895
48regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.03493935
49regulation of peptide hormone secretion (GO:0090276)3.02340883
50negative regulation of protein oligomerization (GO:0032460)3.02089034
51peptide hormone secretion (GO:0030072)2.95526267
52regulation of peptide secretion (GO:0002791)2.94987120
53axoneme assembly (GO:0035082)2.93052607
54positive regulation of meiosis (GO:0045836)2.92814069
55astrocyte differentiation (GO:0048708)2.92737889
56startle response (GO:0001964)2.90129503
57nitric oxide biosynthetic process (GO:0006809)2.87915856
58regulation of autophagic vacuole assembly (GO:2000785)2.87391072
59positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.85059847
60catecholamine transport (GO:0051937)2.85015974
61positive regulation of neurotransmitter transport (GO:0051590)2.84571360
62peptide secretion (GO:0002790)2.83890390
63negative regulation of gluconeogenesis (GO:0045721)2.82958863
64positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.81935684
65dentate gyrus development (GO:0021542)2.78968823
66potassium ion export (GO:0071435)2.76687629
67alanine transport (GO:0032328)2.74818667
68prostate gland growth (GO:0060736)2.73704254
69positive regulation of calcium ion import (GO:0090280)2.73291455
70righting reflex (GO:0060013)2.71599716
71regulation of hormone secretion (GO:0046883)2.70899381
72phasic smooth muscle contraction (GO:0014821)2.70808306
73positive regulation of meiotic cell cycle (GO:0051446)2.70602129
74substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.69132668
75substrate-independent telencephalic tangential migration (GO:0021826)2.69132668
76response to pheromone (GO:0019236)2.68742256
77renal tubule morphogenesis (GO:0061333)2.67189806
78calcium ion import (GO:0070509)2.66874164
79regulation of energy homeostasis (GO:2000505)2.64479465
80toxin metabolic process (GO:0009404)2.64475826
81reflex (GO:0060004)2.62099130
82regulation of calcium ion-dependent exocytosis (GO:0017158)2.60757635
83positive regulation of hormone secretion (GO:0046887)2.60700378
84adaptation of signaling pathway (GO:0023058)2.60082111
85proline transport (GO:0015824)2.58032197
86regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)2.57221491
87regulation of acrosome reaction (GO:0060046)2.56049684
88vitamin biosynthetic process (GO:0009110)2.55348816
89peristalsis (GO:0030432)2.53178639
90somite rostral/caudal axis specification (GO:0032525)2.53098445
91kidney morphogenesis (GO:0060993)2.52377342
92presynaptic membrane organization (GO:0097090)2.50381704
93positive regulation of glucose metabolic process (GO:0010907)2.50053563
94nonmotile primary cilium assembly (GO:0035058)2.49930360
95mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.49868156
96positive regulation of histone H3-K4 methylation (GO:0051571)2.49775216
97epithelial cilium movement (GO:0003351)2.48746997
98intraciliary transport (GO:0042073)2.48438418
99parental behavior (GO:0060746)2.48224580
100positive regulation of macroautophagy (GO:0016239)2.47790162

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.49969975
2GBX2_23144817_ChIP-Seq_PC3_Human3.19347587
3POU3F2_20337985_ChIP-ChIP_501MEL_Human2.51178972
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.45475790
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.40129409
6ZNF274_21170338_ChIP-Seq_K562_Hela2.35019818
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.32694920
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.29143367
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.00515191
10TAF15_26573619_Chip-Seq_HEK293_Human1.95806792
11IGF1R_20145208_ChIP-Seq_DFB_Human1.93472431
12BMI1_23680149_ChIP-Seq_NPCS_Mouse1.88227970
13FUS_26573619_Chip-Seq_HEK293_Human1.81771898
14AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.80087569
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.77741789
16FLI1_27457419_Chip-Seq_LIVER_Mouse1.76513077
17SMAD4_21799915_ChIP-Seq_A2780_Human1.72831159
18P300_19829295_ChIP-Seq_ESCs_Human1.72446352
19EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.72230066
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.72186305
21PIAS1_25552417_ChIP-Seq_VCAP_Human1.71472624
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.69804700
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63128686
24RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.62541708
25VDR_22108803_ChIP-Seq_LS180_Human1.61933817
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.59986344
27BCAT_22108803_ChIP-Seq_LS180_Human1.59478728
28SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.57435369
29CBX2_27304074_Chip-Seq_ESCs_Mouse1.56314507
30SMAD3_21741376_ChIP-Seq_EPCs_Human1.54239816
31SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53173740
32REST_21632747_ChIP-Seq_MESCs_Mouse1.52298355
33AR_25329375_ChIP-Seq_VCAP_Human1.48493623
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47822370
35MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.45583169
36HTT_18923047_ChIP-ChIP_STHdh_Human1.45142537
37SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41891029
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.38570737
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37968389
40EWS_26573619_Chip-Seq_HEK293_Human1.35763747
41NANOG_18555785_Chip-Seq_ESCs_Mouse1.33188383
42STAT3_23295773_ChIP-Seq_U87_Human1.32764466
43NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32035843
44SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.31818846
45SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.30887398
46REST_18959480_ChIP-ChIP_MESCs_Mouse1.30453952
47OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29097413
48RNF2_27304074_Chip-Seq_NSC_Mouse1.28744939
49EZH2_27304074_Chip-Seq_ESCs_Mouse1.28609553
50ER_23166858_ChIP-Seq_MCF-7_Human1.27872926
51EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.26988348
52TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25623979
53NANOG_19829295_ChIP-Seq_ESCs_Human1.24449895
54SOX2_19829295_ChIP-Seq_ESCs_Human1.24449895
55EED_16625203_ChIP-ChIP_MESCs_Mouse1.23836076
56EZH2_27294783_Chip-Seq_NPCs_Mouse1.23122745
57P53_22387025_ChIP-Seq_ESCs_Mouse1.22013218
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20931939
59FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20750508
60FOXA1_25329375_ChIP-Seq_VCAP_Human1.20750508
61IKZF1_21737484_ChIP-ChIP_HCT116_Human1.19460241
62TP53_22573176_ChIP-Seq_HFKS_Human1.18960101
63HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.18855740
64SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.18259304
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17984697
66SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17254969
67E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.16735735
68NFE2_27457419_Chip-Seq_LIVER_Mouse1.16111545
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15587155
70TCF4_22108803_ChIP-Seq_LS180_Human1.15284198
71SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.14745780
72CBP_20019798_ChIP-Seq_JUKART_Human1.13864877
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13864877
74TCF4_23295773_ChIP-Seq_U87_Human1.12143138
75CMYC_18555785_Chip-Seq_ESCs_Mouse1.10564461
76HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.10236881
77STAT3_18555785_Chip-Seq_ESCs_Mouse1.09711553
78ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09670986
79SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08450313
80SOX2_21211035_ChIP-Seq_LN229_Gbm1.07159378
81E2F1_18555785_Chip-Seq_ESCs_Mouse1.06554338
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.06426571
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05111923
84RUNX2_22187159_ChIP-Seq_PCA_Human1.04855975
85SOX2_18555785_Chip-Seq_ESCs_Mouse1.04799459
86EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.04695788
87FLI1_21867929_ChIP-Seq_TH2_Mouse1.04427837
88CDX2_22108803_ChIP-Seq_LS180_Human1.04080822
89CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03238178
90TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02984888
91TBL1_22424771_ChIP-Seq_293T_Human1.02695332
92* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02508536
93* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02157165
94SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.02118735
95SALL1_21062744_ChIP-ChIP_HESCs_Human1.01411728
96TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00413964
97JARID2_20064375_ChIP-Seq_MESCs_Mouse1.00063874
98GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99931986
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99772259
100MTF2_20144788_ChIP-Seq_MESCs_Mouse0.97200294

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.37050510
2MP0002909_abnormal_adrenal_gland3.97568616
3MP0005379_endocrine/exocrine_gland_phen3.61659230
4MP0003195_calcinosis3.31228494
5MP0003283_abnormal_digestive_organ3.07191666
6MP0009780_abnormal_chondrocyte_physiolo3.06882953
7MP0001944_abnormal_pancreas_morphology3.03964080
8MP0002693_abnormal_pancreas_physiology2.88329652
9MP0003122_maternal_imprinting2.82907350
10MP0003787_abnormal_imprinting2.76090244
11MP0005645_abnormal_hypothalamus_physiol2.67711601
12MP0002163_abnormal_gland_morphology2.64155510
13MP0009046_muscle_twitch2.47572864
14MP0002876_abnormal_thyroid_physiology2.43928641
15MP0003880_abnormal_central_pattern2.29033359
16MP0000013_abnormal_adipose_tissue2.20806602
17MP0002928_abnormal_bile_duct2.13909189
18MP0005646_abnormal_pituitary_gland2.13134179
19MP0004270_analgesia2.05889225
20MP0008877_abnormal_DNA_methylation2.05241713
21MP0010234_abnormal_vibrissa_follicle1.92758079
22MP0010386_abnormal_urinary_bladder1.91290779
23MP0006072_abnormal_retinal_apoptosis1.88276335
24MP0004133_heterotaxia1.81718654
25MP0002638_abnormal_pupillary_reflex1.81442793
26MP0005220_abnormal_exocrine_pancreas1.75697933
27MP0002078_abnormal_glucose_homeostasis1.72895436
28MP0003011_delayed_dark_adaptation1.67317297
29MP0002822_catalepsy1.65592925
30MP0000631_abnormal_neuroendocrine_gland1.60939508
31MP0005084_abnormal_gallbladder_morpholo1.60104196
32MP0001984_abnormal_olfaction1.53602167
33MP0004885_abnormal_endolymph1.50318097
34MP0010329_abnormal_lipoprotein_level1.48843575
35MP0003121_genomic_imprinting1.46891252
36MP0002064_seizures1.43867534
37MP0001756_abnormal_urination1.43162488
38MP0009745_abnormal_behavioral_response1.42051546
39MP0002139_abnormal_hepatobiliary_system1.40114623
40MP0004043_abnormal_pH_regulation1.40021030
41MP0005365_abnormal_bile_salt1.34379831
42MP0005332_abnormal_amino_acid1.34032330
43MP0005551_abnormal_eye_electrophysiolog1.32548090
44MP0004142_abnormal_muscle_tone1.28549058
45MP0005448_abnormal_energy_balance1.27976445
46MP0000372_irregular_coat_pigmentation1.27633903
47MP0002938_white_spotting1.26494068
48MP0002272_abnormal_nervous_system1.23454538
49MP0001501_abnormal_sleep_pattern1.22038195
50MP0008961_abnormal_basal_metabolism1.21763657
51MP0003953_abnormal_hormone_level1.19823650
52MP0003123_paternal_imprinting1.18481514
53MP0000569_abnormal_digit_pigmentation1.18427555
54MP0004019_abnormal_vitamin_homeostasis1.17011633
55MP0005253_abnormal_eye_physiology1.16076883
56MP0002277_abnormal_respiratory_mucosa1.14639962
57MP0006054_spinal_hemorrhage1.13651530
58MP0002653_abnormal_ependyma_morphology1.12485932
59MP0002734_abnormal_mechanical_nocicepti1.11621763
60MP0002557_abnormal_social/conspecific_i1.09171076
61MP0000427_abnormal_hair_cycle1.05755266
62MP0008872_abnormal_physiological_respon1.05090931
63MP0004215_abnormal_myocardial_fiber1.04854569
64MP0001970_abnormal_pain_threshold1.02150125
65MP0002572_abnormal_emotion/affect_behav1.01245023
66MP0005636_abnormal_mineral_homeostasis1.01076649
67MP0005386_behavior/neurological_phenoty0.98392058
68MP0004924_abnormal_behavior0.98392058
69MP0001765_abnormal_ion_homeostasis0.95392836
70MP0005535_abnormal_body_temperature0.95123906
71MP0003633_abnormal_nervous_system0.94669805
72MP0000003_abnormal_adipose_tissue0.94093696
73MP0001905_abnormal_dopamine_level0.90373695
74MP0000639_abnormal_adrenal_gland0.89414047
75MP0002229_neurodegeneration0.89054314
76MP0005187_abnormal_penis_morphology0.84705305
77MP0001502_abnormal_circadian_rhythm0.84280820
78MP0002160_abnormal_reproductive_system0.83805908
79MP0001986_abnormal_taste_sensitivity0.83707353
80MP0000538_abnormal_urinary_bladder0.80835262
81MP0005174_abnormal_tail_pigmentation0.80763826
82MP0003868_abnormal_feces_composition0.80544571
83MP0010678_abnormal_skin_adnexa0.79042795
84MP0002118_abnormal_lipid_homeostasis0.77881620
85MP0004085_abnormal_heartbeat0.76744597
86MP0003890_abnormal_embryonic-extraembry0.76714405
87MP0002733_abnormal_thermal_nociception0.75773657
88MP0003172_abnormal_lysosome_physiology0.75625108
89MP0003879_abnormal_hair_cell0.75294231
90MP0002063_abnormal_learning/memory/cond0.75150035
91MP0000230_abnormal_systemic_arterial0.73223066
92MP0003635_abnormal_synaptic_transmissio0.72708162
93MP0005389_reproductive_system_phenotype0.72191544
94MP0000462_abnormal_digestive_system0.70978657
95MP0000613_abnormal_salivary_gland0.70592592
96MP0002069_abnormal_eating/drinking_beha0.69472874
97MP0003136_yellow_coat_color0.68968619
98MP0005452_abnormal_adipose_tissue0.68795296
99MP0001529_abnormal_vocalization0.67804318
100MP0001486_abnormal_startle_reflex0.67299183

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic seizures (HP:0002173)5.93087853
2Hypoglycemic coma (HP:0001325)4.97312125
3Hyperinsulinemic hypoglycemia (HP:0000825)4.91261798
4Large for gestational age (HP:0001520)4.74275504
5Double outlet right ventricle (HP:0001719)4.52433179
6Congenital malformation of the right heart (HP:0011723)4.52433179
7Ketoacidosis (HP:0001993)4.51957552
8Hyperglycemia (HP:0003074)4.45554207
9Intestinal atresia (HP:0011100)4.36004264
10Hypothermia (HP:0002045)3.81522450
11Symptomatic seizures (HP:0011145)3.56797605
12Abnormality of endocrine pancreas physiology (HP:0012093)3.43929064
13Abnormality of the pancreatic islet cells (HP:0006476)3.43929064
14Abnormality of aromatic amino acid family metabolism (HP:0004338)3.36169744
15Late onset (HP:0003584)3.29491891
16Hemiparesis (HP:0001269)3.02708599
17Epileptiform EEG discharges (HP:0011182)2.98569943
18EEG with generalized epileptiform discharges (HP:0011198)2.95758873
19Ketosis (HP:0001946)2.93906615
20Agitation (HP:0000713)2.91568362
21Insulin-resistant diabetes mellitus (HP:0000831)2.85545457
22Hypsarrhythmia (HP:0002521)2.79150270
23Enlarged penis (HP:0000040)2.77988292
24Progressive macrocephaly (HP:0004481)2.75770749
25Medial flaring of the eyebrow (HP:0010747)2.72005051
26Abnormality of vitamin B metabolism (HP:0004340)2.71349901
27Gastrointestinal atresia (HP:0002589)2.60821384
28Increased CSF protein (HP:0002922)2.56005185
29Nephronophthisis (HP:0000090)2.53136674
30Polydipsia (HP:0001959)2.50446643
31Abnormal drinking behavior (HP:0030082)2.50446643
32Muscular hypotonia of the trunk (HP:0008936)2.48779887
33Progressive cerebellar ataxia (HP:0002073)2.47030664
34Abdominal situs inversus (HP:0003363)2.46296273
35Abnormality of abdominal situs (HP:0011620)2.46296273
36Oligodactyly (hands) (HP:0001180)2.44304349
37Prominent metopic ridge (HP:0005487)2.43199602
38Acute necrotizing encephalopathy (HP:0006965)2.40652517
39Aqueductal stenosis (HP:0002410)2.39371383
40Limb dystonia (HP:0002451)2.39019289
41Molar tooth sign on MRI (HP:0002419)2.32475543
42Abnormality of midbrain morphology (HP:0002418)2.32475543
43Pancreatic islet-cell hyperplasia (HP:0004510)2.32192532
44Abnormality of the renal cortex (HP:0011035)2.31630329
45Gait imbalance (HP:0002141)2.30698024
46Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.30562011
47Pancreatic fibrosis (HP:0100732)2.27163068
48Congenital primary aphakia (HP:0007707)2.24770210
49Sex reversal (HP:0012245)2.23689456
50Abnormal sex determination (HP:0012244)2.23689456
51Postural tremor (HP:0002174)2.19842192
52Abnormality of vitamin metabolism (HP:0100508)2.19402311
53Hyperthyroidism (HP:0000836)2.19108000
54Congenital sensorineural hearing impairment (HP:0008527)2.18950177
55Abnormality of the metopic suture (HP:0005556)2.15800548
56Pancreatic cysts (HP:0001737)2.15734445
57Mitochondrial inheritance (HP:0001427)2.13283399
58Absent/shortened dynein arms (HP:0200106)2.11895488
59Dynein arm defect of respiratory motile cilia (HP:0012255)2.11895488
60Nephrogenic diabetes insipidus (HP:0009806)2.11600476
61Hypokinesia (HP:0002375)2.09283261
62Abnormality of the renal medulla (HP:0100957)2.09034045
63Methylmalonic acidemia (HP:0002912)2.08739072
64Hyperventilation (HP:0002883)2.05653421
65Testicular neoplasm (HP:0010788)2.03565859
66Congenital stationary night blindness (HP:0007642)2.02585047
67Abnormal rod and cone electroretinograms (HP:0008323)2.00722028
68Tongue fasciculations (HP:0001308)2.00589496
69Hypoplasia of the fovea (HP:0007750)1.99513452
70Aplasia/Hypoplasia of the fovea (HP:0008060)1.99513452
71Aplasia/hypoplasia of the uterus (HP:0008684)1.99487594
72Conjunctival hamartoma (HP:0100780)1.99361827
73Hypomagnesemia (HP:0002917)1.98720543
74Tubular atrophy (HP:0000092)1.98642614
75Attenuation of retinal blood vessels (HP:0007843)1.97188367
76Furrowed tongue (HP:0000221)1.96764069
77Abnormality of urine glucose concentration (HP:0011016)1.95574883
78Glycosuria (HP:0003076)1.95574883
79Abnormal albumin level (HP:0012116)1.95178718
80Hypoalbuminemia (HP:0003073)1.95178718
81Renal cortical cysts (HP:0000803)1.92253106
82True hermaphroditism (HP:0010459)1.92230934
83Hematochezia (HP:0002573)1.90460393
84Anxiety (HP:0000739)1.88898587
85Gaze-evoked nystagmus (HP:0000640)1.87853804
86Increased CSF lactate (HP:0002490)1.87618332
87Delayed gross motor development (HP:0002194)1.87245093
88Acute encephalopathy (HP:0006846)1.84980145
89Abnormal respiratory epithelium morphology (HP:0012253)1.83927626
90Abnormal respiratory motile cilium morphology (HP:0005938)1.83927626
91Hepatic necrosis (HP:0002605)1.82571274
92Abnormal mitochondria in muscle tissue (HP:0008316)1.82526115
93Progressive inability to walk (HP:0002505)1.82284672
94Abnormal ciliary motility (HP:0012262)1.82151007
95Bony spicule pigmentary retinopathy (HP:0007737)1.80885818
96Neoplasm of the adrenal cortex (HP:0100641)1.78540028
97Hamartoma of the eye (HP:0010568)1.75904239
98Polyphagia (HP:0002591)1.74004709
99Poor suck (HP:0002033)1.73205974
100Methylmalonic aciduria (HP:0012120)1.72740418

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.48533098
2FGFR23.78952931
3WNK33.57828413
4MAP3K123.22476145
5PHKG12.58434065
6PHKG22.58434065
7MST42.48414114
8NTRK32.36341664
9DAPK22.30615179
10EPHA32.09856370
11TNIK2.03799166
12MAP4K21.94265608
13STK241.93738739
14PAK31.93005498
15PINK11.90564803
16CASK1.89786930
17STK38L1.86514643
18ADRBK21.85015998
19GRK11.84911470
20NLK1.78696376
21FER1.77682664
22MAP2K61.69587047
23PASK1.66044866
24CSNK1G11.60683607
25MAP3K21.55932268
26FGFR31.51598020
27PNCK1.36153838
28INSRR1.34906497
29STK31.31860561
30WNK41.31619566
31MAP2K41.24014431
32ZAK1.22563622
33CSNK1G21.21335807
34PRKCE1.16580260
35UHMK11.14702741
36CSNK1G31.13687875
37YES11.09645582
38ERBB31.06835148
39ACVR1B1.06417818
40BMPR1B1.06253789
41MAPK150.99368654
42PRKCG0.93929450
43HIPK20.90479450
44NUAK10.88132346
45TRPM70.85677536
46PLK20.78370107
47MAP3K90.76536171
48TAOK10.75347799
49IRAK20.74898329
50IRAK10.74775082
51PRKCI0.72665060
52STK110.72319589
53OXSR10.70681409
54MAP3K10.70473789
55EPHB10.69989906
56SGK20.69883796
57CAMK2D0.69577939
58CSNK1A1L0.69099375
59STK390.67050384
60NTRK20.64057342
61ADRBK10.60432654
62PLK30.59120404
63PTK2B0.57835839
64PRKAA10.57200407
65SGK4940.53256429
66SGK2230.53256429
67MAPK130.53254799
68PRKG10.52447282
69MAP3K40.51898822
70LMTK20.49435663
71PKN10.48093253
72CSNK1A10.47309506
73GSK3A0.44351604
74CAMK2A0.44052133
75PRKG20.43905006
76DYRK20.43151541
77PRKACA0.42453431
78PRKAA20.41933830
79TLK10.39753536
80SGK10.38072724
81CDK30.36952260
82MARK10.36663748
83TIE10.35233283
84PRKCZ0.34722488
85PRKACB0.34093184
86ROCK10.33322529
87CHUK0.33302824
88STK160.32758717
89TNK20.32394108
90STK40.30818077
91PRKCA0.30588623
92MAP3K50.30407320
93CSNK1E0.28368500
94CSNK1D0.27072870
95WNK10.27031616
96OBSCN0.24650905
97BMPR20.24287092
98RPS6KA50.23853771
99TAOK30.23169893
100MAP2K70.22830245

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049507.07435422
2Protein export_Homo sapiens_hsa030603.12295114
3Insulin secretion_Homo sapiens_hsa049112.90542851
4Oxidative phosphorylation_Homo sapiens_hsa001902.43477032
5Butanoate metabolism_Homo sapiens_hsa006502.38277645
6Vitamin B6 metabolism_Homo sapiens_hsa007502.33737914
7Folate biosynthesis_Homo sapiens_hsa007902.27146962
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.24006301
9Collecting duct acid secretion_Homo sapiens_hsa049662.11499857
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.02687927
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.86100095
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.78013714
13Fatty acid elongation_Homo sapiens_hsa000621.66726104
14Type I diabetes mellitus_Homo sapiens_hsa049401.66411593
15Phototransduction_Homo sapiens_hsa047441.63341954
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.58666679
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.54530663
18Sulfur metabolism_Homo sapiens_hsa009201.49271583
19Parkinsons disease_Homo sapiens_hsa050121.47464927
20Selenocompound metabolism_Homo sapiens_hsa004501.46000766
21Type II diabetes mellitus_Homo sapiens_hsa049301.41981932
22Amphetamine addiction_Homo sapiens_hsa050311.30133153
23Cocaine addiction_Homo sapiens_hsa050301.29087611
24Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.28253397
25Regulation of autophagy_Homo sapiens_hsa041401.28086581
26Synaptic vesicle cycle_Homo sapiens_hsa047211.27873167
27Ether lipid metabolism_Homo sapiens_hsa005651.25566497
28Circadian rhythm_Homo sapiens_hsa047101.21886871
29Tryptophan metabolism_Homo sapiens_hsa003801.19422598
30Alzheimers disease_Homo sapiens_hsa050101.17459636
31Cardiac muscle contraction_Homo sapiens_hsa042601.16002578
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.15176893
33Peroxisome_Homo sapiens_hsa041461.10066390
34Renin secretion_Homo sapiens_hsa049241.09251484
35Nicotine addiction_Homo sapiens_hsa050331.04625099
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.03310099
37Dopaminergic synapse_Homo sapiens_hsa047281.01974427
38Circadian entrainment_Homo sapiens_hsa047131.01506540
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.96560862
40SNARE interactions in vesicular transport_Homo sapiens_hsa041300.96504654
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94700594
42Vibrio cholerae infection_Homo sapiens_hsa051100.94157144
43GABAergic synapse_Homo sapiens_hsa047270.93945696
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92976113
45ABC transporters_Homo sapiens_hsa020100.92733820
46Linoleic acid metabolism_Homo sapiens_hsa005910.92486272
47beta-Alanine metabolism_Homo sapiens_hsa004100.87846053
48Nitrogen metabolism_Homo sapiens_hsa009100.85310035
49Fatty acid metabolism_Homo sapiens_hsa012120.83259738
50Sphingolipid metabolism_Homo sapiens_hsa006000.82913775
51Huntingtons disease_Homo sapiens_hsa050160.80956087
52Primary bile acid biosynthesis_Homo sapiens_hsa001200.80938221
53Long-term depression_Homo sapiens_hsa047300.79905423
54Dorso-ventral axis formation_Homo sapiens_hsa043200.78676591
55Serotonergic synapse_Homo sapiens_hsa047260.78515061
56Propanoate metabolism_Homo sapiens_hsa006400.77445726
57Glutamatergic synapse_Homo sapiens_hsa047240.74978788
58alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72070924
59Morphine addiction_Homo sapiens_hsa050320.71397257
60Ovarian steroidogenesis_Homo sapiens_hsa049130.71213767
61Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71012855
62Mineral absorption_Homo sapiens_hsa049780.69300486
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.68816980
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67791643
65Glutathione metabolism_Homo sapiens_hsa004800.67238812
66Glucagon signaling pathway_Homo sapiens_hsa049220.65490845
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64802122
68Salivary secretion_Homo sapiens_hsa049700.60695683
69Thyroid hormone synthesis_Homo sapiens_hsa049180.60183104
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59193441
71cAMP signaling pathway_Homo sapiens_hsa040240.58576348
72Arachidonic acid metabolism_Homo sapiens_hsa005900.57677214
73Steroid biosynthesis_Homo sapiens_hsa001000.56775996
74Vitamin digestion and absorption_Homo sapiens_hsa049770.55836950
75Fatty acid degradation_Homo sapiens_hsa000710.55137978
76Retinol metabolism_Homo sapiens_hsa008300.54591850
77Metabolic pathways_Homo sapiens_hsa011000.54303338
78Chemical carcinogenesis_Homo sapiens_hsa052040.53031451
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.51490966
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51233546
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50888260
82Caffeine metabolism_Homo sapiens_hsa002320.50744226
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.50647990
84Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.49589955
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46018087
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45969089
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45557909
88Pancreatic secretion_Homo sapiens_hsa049720.45505060
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44977809
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44240675
91Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43591162
92Lysosome_Homo sapiens_hsa041420.41522879
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.38078259
94Calcium signaling pathway_Homo sapiens_hsa040200.37251288
95Taste transduction_Homo sapiens_hsa047420.36088468
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.35207492
97N-Glycan biosynthesis_Homo sapiens_hsa005100.33923279
98Arginine biosynthesis_Homo sapiens_hsa002200.33702190
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.32847642
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30524391

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