CFD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the S1, or chymotrypsin, family of serine peptidases. This protease catalyzes the cleavage of factor B, the rate-limiting step of the alternative pathway of complement activation. This protein also functions as an adipokine, a cell signaling protein secreted by adipocytes, which regulates insulin secretion in mice. Mutations in this gene underlie complement factor D deficiency, which is associated with recurrent bacterial meningitis infections in human patients. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protease. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of sequestering of triglyceride (GO:0010889)8.86016468
2white fat cell differentiation (GO:0050872)8.77849089
3triglyceride catabolic process (GO:0019433)8.72852971
4brown fat cell differentiation (GO:0050873)7.97506123
5valine metabolic process (GO:0006573)7.86967354
6acylglycerol catabolic process (GO:0046464)7.83441742
7neutral lipid catabolic process (GO:0046461)7.83441742
8biotin metabolic process (GO:0006768)6.50288924
9regulation of cholesterol storage (GO:0010885)6.08274126
10lipid particle organization (GO:0034389)6.02596369
11glycerolipid catabolic process (GO:0046503)5.86208307
12negative regulation of macrophage derived foam cell differentiation (GO:0010745)5.81970323
13triglyceride biosynthetic process (GO:0019432)5.52124693
14positive regulation of fatty acid oxidation (GO:0046321)5.40718638
15acylglycerol biosynthetic process (GO:0046463)5.25500134
16neutral lipid biosynthetic process (GO:0046460)5.25500134
17positive regulation of fatty acid beta-oxidation (GO:0032000)5.18109482
18fatty acid transmembrane transport (GO:1902001)5.16008876
19branched-chain amino acid metabolic process (GO:0009081)5.03478262
20branched-chain amino acid catabolic process (GO:0009083)4.87367557
21lipid storage (GO:0019915)4.83215794
22protein heterotrimerization (GO:0070208)4.70520265
23negative regulation of protein autophosphorylation (GO:0031953)4.63959833
24carnitine shuttle (GO:0006853)4.60113493
25negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)4.58719448
26fatty acid beta-oxidation (GO:0006635)4.53172476
27cellular response to lithium ion (GO:0071285)4.50605853
28triglyceride metabolic process (GO:0006641)4.49681457
29fatty-acyl-CoA biosynthetic process (GO:0046949)4.39509942
30acyl-CoA biosynthetic process (GO:0071616)4.32689538
31thioester biosynthetic process (GO:0035384)4.32689538
32long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.32673763
33negative regulation of granulocyte differentiation (GO:0030853)4.32021322
34long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.28710846
35regulation of macrophage derived foam cell differentiation (GO:0010743)4.26408206
36negative regulation of phagocytosis (GO:0050765)4.24630016
37fatty-acyl-CoA metabolic process (GO:0035337)4.23201093
38acylglycerol metabolic process (GO:0006639)4.22508261
39regulation of glycogen (starch) synthase activity (GO:2000465)4.21275295
40positive regulation of glomerulus development (GO:0090193)4.20167593
41positive regulation of fatty acid metabolic process (GO:0045923)4.16836981
42neutral lipid metabolic process (GO:0006638)4.16667927
43plasma lipoprotein particle clearance (GO:0034381)4.15508802
44negative regulation of lipid storage (GO:0010888)4.14644633
45fatty acid oxidation (GO:0019395)4.10349522
46coenzyme A biosynthetic process (GO:0015937)4.07508754
47lipid oxidation (GO:0034440)4.02341777
48regulation of fatty acid oxidation (GO:0046320)4.02171105
49regulation of fatty acid beta-oxidation (GO:0031998)4.01655319
50pentose-phosphate shunt (GO:0006098)4.01366261
51fatty acid homeostasis (GO:0055089)4.00292761
52NADPH regeneration (GO:0006740)3.98278639
53regulation of cAMP-dependent protein kinase activity (GO:2000479)3.97805910
54positive regulation of lipid catabolic process (GO:0050996)3.95129620
55alpha-linolenic acid metabolic process (GO:0036109)3.94159571
56cellular response to epinephrine stimulus (GO:0071872)3.88917931
57regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.88496570
58fatty acid catabolic process (GO:0009062)3.87036479
59positive regulation of glucose import (GO:0046326)3.87031775
60negative regulation of macrophage differentiation (GO:0045650)3.86810917
61positive regulation of cholesterol efflux (GO:0010875)3.84514157
62response to dietary excess (GO:0002021)3.83609752
63regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.81165928
64positive regulation of lipid storage (GO:0010884)3.80623581
65positive regulation of cholesterol transport (GO:0032376)3.79897162
66positive regulation of sterol transport (GO:0032373)3.79897162
67tricarboxylic acid metabolic process (GO:0072350)3.76463683
68carnitine transmembrane transport (GO:1902603)3.76101492
69negative regulation of metanephros development (GO:0072217)3.74408148
70negative regulation of erythrocyte differentiation (GO:0045647)3.74217370
71response to peptidoglycan (GO:0032494)3.74202994
72oxaloacetate metabolic process (GO:0006107)3.73719642
73neutrophil activation involved in immune response (GO:0002283)3.72999705
74negative regulation of DNA biosynthetic process (GO:2000279)3.72435130
75growth hormone receptor signaling pathway (GO:0060396)3.72003964
76negative regulation of gluconeogenesis (GO:0045721)3.71532301
77positive regulation of monocyte chemotaxis (GO:0090026)3.70538675
78acetyl-CoA metabolic process (GO:0006084)3.68678234
79negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.61531813
80positive regulation of gamma-delta T cell activation (GO:0046645)3.57304872
81regulation of triglyceride catabolic process (GO:0010896)3.57030975
82positive regulation of cellular response to insulin stimulus (GO:1900078)3.49835620
83L-serine transport (GO:0015825)3.49213149
84regulation of triglyceride metabolic process (GO:0090207)3.47550181
85amino-acid betaine transport (GO:0015838)3.47185832
86carnitine transport (GO:0015879)3.47185832
87cellular extravasation (GO:0045123)3.46854352
88barbed-end actin filament capping (GO:0051016)3.45406494
89regulation of lipid storage (GO:0010883)3.45165051
90cellular response to growth hormone stimulus (GO:0071378)3.44276241
91retina vasculature morphogenesis in camera-type eye (GO:0061299)3.43278311
92regulation of triglyceride biosynthetic process (GO:0010866)3.42418153
93fat cell differentiation (GO:0045444)3.40703707
94negative regulation of interleukin-12 production (GO:0032695)3.35183861
95negative regulation of smooth muscle cell migration (GO:0014912)3.35146933
96positive regulation of glucose transport (GO:0010828)3.31945311
97regulation of receptor binding (GO:1900120)3.31163958
98positive regulation of triglyceride metabolic process (GO:0090208)3.30256462
99positive regulation of calcium ion import (GO:0090280)3.28340386
100modulation of growth of symbiont involved in interaction with host (GO:0044144)3.26040897
101regulation of growth of symbiont in host (GO:0044126)3.26040897
102negative regulation of growth of symbiont in host (GO:0044130)3.26040897
103negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.26040897
104positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.22827843
105regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.22167007
1062-oxoglutarate metabolic process (GO:0006103)3.18351282
107CDP-diacylglycerol biosynthetic process (GO:0016024)3.18094073
108negative regulation of nitric oxide biosynthetic process (GO:0045019)3.16849159
109coenzyme A metabolic process (GO:0015936)3.15536115
110transcytosis (GO:0045056)3.14753472
111intracellular lipid transport (GO:0032365)3.13538803
112diacylglycerol metabolic process (GO:0046339)3.13019893
113ovulation from ovarian follicle (GO:0001542)3.12930008
114regulation of chemokine biosynthetic process (GO:0045073)3.12619382
115regulation of mononuclear cell migration (GO:0071675)3.12455471
116regulation of gonadotropin secretion (GO:0032276)3.10071903
117response to epinephrine (GO:0071871)3.09974983
118macrophage activation involved in immune response (GO:0002281)3.07269851
119macrophage differentiation (GO:0030225)3.06619418
120immunoglobulin mediated immune response (GO:0016064)3.03463512
121positive regulation of lipoprotein lipase activity (GO:0051006)3.02244353
122positive regulation of triglyceride lipase activity (GO:0061365)3.02244353
123positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.00244827
124detection of other organism (GO:0098543)2.99603176
125negative regulation of tumor necrosis factor production (GO:0032720)2.99139586
126regulation of cellular extravasation (GO:0002691)2.95020118
127regulation of monocyte chemotaxis (GO:0090025)2.93907794
128negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.90171956
129modulation by symbiont of host defense response (GO:0052031)2.89541464
130modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.89541464
131modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.89541464
132positive regulation by organism of defense response of other organism involved in symbiotic interact2.89541464
133modulation by symbiont of host immune response (GO:0052553)2.89541464
134positive regulation by symbiont of host defense response (GO:0052509)2.89541464
135detection of bacterium (GO:0016045)2.84237377
136negative regulation of norepinephrine secretion (GO:0010700)2.78459599
137neutrophil mediated immunity (GO:0002446)2.77860381
138regulation of interleukin-8 biosynthetic process (GO:0045414)2.72723613
139regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.69101270
140reactive oxygen species biosynthetic process (GO:1903409)2.69040753
141positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.67885808
142regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.66346764
143microglial cell activation (GO:0001774)2.65658269
144regulation of tumor necrosis factor production (GO:0032680)2.65143994
145antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.64393969
146negative regulation of cell killing (GO:0031342)2.63044972
147negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.63044972
148angiotensin maturation (GO:0002003)2.62652696
149response to hydroperoxide (GO:0033194)2.60654623
150regulation of membrane protein ectodomain proteolysis (GO:0051043)2.56593820
151macrophage activation (GO:0042116)2.56543936
152keratan sulfate catabolic process (GO:0042340)2.56386861
153mannose metabolic process (GO:0006013)2.56165919
154detection of external biotic stimulus (GO:0098581)2.55954356
155positive regulation of chemokine biosynthetic process (GO:0045080)2.55191498
156cellular response to thyroid hormone stimulus (GO:0097067)2.54228682
157antigen processing and presentation of endogenous antigen (GO:0019883)2.52916846
158negative regulation of smooth muscle cell proliferation (GO:0048662)2.52651112
159regulation of macrophage chemotaxis (GO:0010758)2.51582646
160mature B cell differentiation involved in immune response (GO:0002313)2.51343206
161regulation of gamma-delta T cell activation (GO:0046643)2.50821028
162lipopolysaccharide-mediated signaling pathway (GO:0031663)2.50744835
163positive regulation of cellular amide metabolic process (GO:0034250)2.48689597
164interferon-gamma-mediated signaling pathway (GO:0060333)2.47553372
165regulation of mast cell degranulation (GO:0043304)2.46385758
166negative regulation of cytokine production involved in immune response (GO:0002719)2.46318525
167cellular response to type I interferon (GO:0071357)2.46069146
168type I interferon signaling pathway (GO:0060337)2.46069146
169response to muramyl dipeptide (GO:0032495)2.45800408
170regulation of monocyte differentiation (GO:0045655)2.44636486
171response to type I interferon (GO:0034340)2.43169411
172positive regulation of B cell differentiation (GO:0045579)2.42414926
173low-density lipoprotein particle clearance (GO:0034383)10.0541686

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse6.57635673
2CLOCK_20551151_ChIP-Seq_293T_Human4.78929122
3* VDR_21846776_ChIP-Seq_THP-1_Human3.17826856
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.15945965
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.97769511
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.94441556
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.76506338
8* VDR_24763502_ChIP-Seq_THP-1_Human2.69620577
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.69239503
10* RXR_22158963_ChIP-Seq_LIVER_Mouse2.65835512
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.64948950
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.55412613
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.53346790
14PPARG_20176806_ChIP-Seq_3T3-L1_Mouse2.43294971
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.34413896
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.31144625
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.26869842
18PPARA_22158963_ChIP-Seq_LIVER_Mouse2.26713598
19RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.21532457
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.16629865
21RARG_19884340_ChIP-ChIP_MEFs_Mouse2.08958621
22PPARG_20887899_ChIP-Seq_3T3-L1_Mouse2.01887278
23PPARG_19300518_ChIP-PET_3T3-L1_Mouse15.2165354
24EGR1_19374776_ChIP-ChIP_THP-1_Human1.96738730
25CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.92827348
26FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.85759345
27SCL_19346495_ChIP-Seq_HPC-7_Human1.80041492
28* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.75779530
29NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.75650050
30GATA1_22025678_ChIP-Seq_K562_Human1.70568383
31ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.70035358
32LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.68522300
33STAT4_19710469_ChIP-ChIP_TH1__Mouse1.65467170
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.64813910
35ZNF263_19887448_ChIP-Seq_K562_Human1.64386622
36SPI1_23127762_ChIP-Seq_K562_Human1.62104396
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.62011231
38KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.58711406
39TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56236778
40PPAR_26484153_Chip-Seq_NCI-H1993_Human1.55985901
41* SPI1_23547873_ChIP-Seq_NB4_Human1.51527229
42STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.51277730
43NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.50950900
44* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.49379646
45LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.48801623
46CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.47557526
47MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.44330902
48GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.42182139
49E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.40725663
50BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.40355662
51TCF7_22412390_ChIP-Seq_EML_Mouse1.39026821
52STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.34708274
53SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.33819917
54IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.33312721
55MAF_26560356_Chip-Seq_TH1_Human1.33264294
56PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32099365
57TBX20_22328084_ChIP-Seq_HEART_Mouse1.31875542
58TBX20_22080862_ChIP-Seq_HEART_Mouse1.31875542
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31541014
60HIF1A_21447827_ChIP-Seq_MCF-7_Human1.28037370
61UTX_26944678_Chip-Seq_JUKART_Human1.27973687
62PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27901638
63ESR2_21235772_ChIP-Seq_MCF-7_Human1.27405021
64VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24972081
65* BCL6_27268052_Chip-Seq_Bcells_Human1.24830432
66MAF_26560356_Chip-Seq_TH2_Human1.23979076
67CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22093878
68FOXO3_23340844_ChIP-Seq_DLD1_Human1.21325663
69STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.21250338
70RUNX_20019798_ChIP-Seq_JUKART_Human1.16864801
71GATA1_19941827_ChIP-Seq_MEL_Mouse1.16700399
72BCOR_27268052_Chip-Seq_Bcells_Human1.14625497
73CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.14408926
74GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14203215
75CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13330783
76TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11795427
77STAT1_20625510_ChIP-Seq_HELA_Human1.11445634
78* SA1_27219007_Chip-Seq_ERYTHROID_Human1.10770113
79CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09754919
80KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07627235
81CJUN_26792858_Chip-Seq_BT549_Human1.07299572
82SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06686058
83IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05944956
84GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05882212
85ELF1_20517297_ChIP-Seq_JURKAT_Human1.05778992
86VDR_24787735_ChIP-Seq_THP-1_Human1.05672230
87* P68_20966046_ChIP-Seq_HELA_Human1.04724896
88DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04530827
89GATA2_21666600_ChIP-Seq_HMVEC_Human1.04462317
90* CTCF_26484167_Chip-Seq_Bcells_Mouse1.04014989
91CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03699688
92CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.03395630
93PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.00910254
94SMC1_22415368_ChIP-Seq_MEFs_Mouse0.98610845
95RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98473529
96PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97774188
97SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97189638
98TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97186802
99GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95303907
100P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95023569
101BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.94859073
102MYC_22102868_ChIP-Seq_BL_Human0.94430047
103SA1_27219007_Chip-Seq_Bcells_Human0.94200784
104THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94142583
105FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.93984280
106PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.93648922
107EP300_21415370_ChIP-Seq_HL-1_Mouse0.92976274
108WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90711624
109Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.88955916
110ESR1_21235772_ChIP-Seq_MCF-7_Human0.87933370
111SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.86562114
112CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.86354431
113TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.86305195
114ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.84469064
115ESR1_20079471_ChIP-ChIP_T-47D_Human0.84167585
116ELK4_26923725_Chip-Seq_MESODERM_Mouse0.81906869
117* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.81288984
118FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.81015118
119LXR_22292898_ChIP-Seq_THP-1_Human0.80532925
120* ELK3_25401928_ChIP-Seq_HUVEC_Human0.79659720
121GATA1_19941826_ChIP-Seq_K562_Human0.79055998
122SOX2_20726797_ChIP-Seq_SW620_Human0.78808080
123ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.77193153
124RACK7_27058665_Chip-Seq_MCF-7_Human0.76871187
125NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.76840120
126NRF2_20460467_ChIP-Seq_MEFs_Mouse0.76840120
127RXR_22108803_ChIP-Seq_LS180_Human0.76653058
128KDM2B_26808549_Chip-Seq_SUP-B15_Human0.76510886
129SALL1_21062744_ChIP-ChIP_HESCs_Human0.76502442
130CTNNB1_20460455_ChIP-Seq_HCT116_Human0.76151870
131FOXA2_19822575_ChIP-Seq_HepG2_Human0.73690684
132SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.73023698
133GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.70849684
134RNF2_18974828_ChIP-Seq_MESCs_Mouse0.70460805
135EZH2_18974828_ChIP-Seq_MESCs_Mouse0.70460805
136* KDM2B_26808549_Chip-Seq_K562_Human0.68704252
137PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.67090111
138ATF3_27146783_Chip-Seq_COLON_Human0.66738828
139ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.66607785
140GATA3_24758297_ChIP-Seq_MCF-7_Human0.65797768
141EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.65688128
142MYB_21317192_ChIP-Seq_ERMYB_Mouse0.65208180
143CDX2_20551321_ChIP-Seq_CACO-2_Human0.64747461
144SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.64616361
145SOX2_27498859_Chip-Seq_STOMACH_Mouse0.64275654
146IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.63976375
147SALL4_18804426_ChIP-ChIP_XEN_Mouse0.63047705
148KDM2B_26808549_Chip-Seq_DND41_Human0.62923391
149IRF8_22096565_ChIP-ChIP_GC-B_Human0.61950776
150SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.61077042
151GATA2_19941826_ChIP-Seq_K562_Human0.60929099
152RUNX1_27514584_Chip-Seq_MCF-7_Human0.59482568
153ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.59428959
154CSB_26484114_Chip-Seq_FIBROBLAST_Human0.56912631
155BCAT_22108803_ChIP-Seq_LS180_Human0.55963894
156NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.55325465
157* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.54867306
158WT1_25993318_ChIP-Seq_PODOCYTE_Human0.54319441
159* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.54281954
160HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.54209684
161SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.53753951
162EGR1_23403033_ChIP-Seq_LIVER_Mouse0.53735753

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose7.86044180
2MP0005666_abnormal_adipose_tissue5.63032784
3MP0004185_abnormal_adipocyte_glucose5.53924945
4MP0004130_abnormal_muscle_cell5.48203434
5MP0008438_abnormal_cutaneous_collagen4.33137756
6MP0005375_adipose_tissue_phenotype4.09765954
7MP0003303_peritoneal_inflammation3.39575178
8MP0009278_abnormal_bone_marrow3.22882673
9MP0000013_abnormal_adipose_tissue3.13587506
10MP0002971_abnormal_brown_adipose3.06023506
11MP0005275_abnormal_skin_tensile3.05031814
12MP0002837_dystrophic_cardiac_calcinosis2.82104202
13MP0010329_abnormal_lipoprotein_level2.79966590
14MP0000003_abnormal_adipose_tissue2.71383304
15MP0003436_decreased_susceptibility_to2.65465491
16MP0009115_abnormal_fat_cell2.60205603
17MP0005397_hematopoietic_system_phenotyp2.50244685
18MP0001545_abnormal_hematopoietic_system2.50244685
19MP0005334_abnormal_fat_pad2.49692642
20MP0002876_abnormal_thyroid_physiology2.45014245
21MP0003191_abnormal_cellular_cholesterol2.41186548
22* MP0002419_abnormal_innate_immunity2.18718655
23MP0009785_altered_susceptibility_to2.18498040
24MP0006082_CNS_inflammation2.17468936
25MP0003705_abnormal_hypodermis_morpholog2.17392003
26MP0001661_extended_life_span2.15485339
27MP0002970_abnormal_white_adipose2.13005480
28MP0002148_abnormal_hypersensitivity_rea2.05838473
29MP0003011_delayed_dark_adaptation2.04796326
30MP0002118_abnormal_lipid_homeostasis1.92179322
31* MP0005025_abnormal_response_to1.88341773
32MP0005000_abnormal_immune_tolerance1.84770222
33MP0001835_abnormal_antigen_presentation1.82603382
34MP0003724_increased_susceptibility_to1.79254206
35MP0003075_altered_response_to1.77461041
36MP0003959_abnormal_lean_body1.73440399
37MP0005535_abnormal_body_temperature1.72075973
38MP0004272_abnormal_basement_membrane1.69863180
39MP0009840_abnormal_foam_cell1.66646501
40MP0001790_abnormal_immune_system1.63779258
41MP0005387_immune_system_phenotype1.63779258
42MP0004510_myositis1.60947668
43MP0001853_heart_inflammation1.58384170
44MP0001881_abnormal_mammary_gland1.56982923
45MP0003828_pulmonary_edema1.54338195
46MP0003186_abnormal_redox_activity1.53644627
47MP0005448_abnormal_energy_balance1.53125665
48MP0006138_congestive_heart_failure1.44191391
49MP0002452_abnormal_antigen_presenting1.43236517
50MP0000604_amyloidosis1.42797318
51MP0000858_altered_metastatic_potential1.42382808
52MP0002723_abnormal_immune_serum1.39120257
53MP0005452_abnormal_adipose_tissue1.38133423
54MP0003300_gastrointestinal_ulcer1.35520032
55MP0000685_abnormal_immune_system1.35083663
56MP0002420_abnormal_adaptive_immunity1.33990278
57MP0002933_joint_inflammation1.33093529
58MP0001819_abnormal_immune_cell1.32598477
59MP0002796_impaired_skin_barrier1.31703202
60MP0003172_abnormal_lysosome_physiology1.31458220
61MP0002405_respiratory_system_inflammati1.31031808
62MP0009764_decreased_sensitivity_to1.30855266
63MP0001542_abnormal_bone_strength1.28534529
64MP0008775_abnormal_heart_ventricle1.28284762
65MP0000609_abnormal_liver_physiology1.28262034
66MP0001845_abnormal_inflammatory_respons1.27741332
67MP0004947_skin_inflammation1.27356405
68MP0002254_reproductive_system_inflammat1.26920803
69MP0008469_abnormal_protein_level1.24303357
70MP0002078_abnormal_glucose_homeostasis1.24181889
71MP0005671_abnormal_response_to1.23139823
72MP0005365_abnormal_bile_salt1.22551280
73MP0003690_abnormal_glial_cell1.22092219
74* MP0001800_abnormal_humoral_immune1.21590068
75MP0003279_aneurysm1.19094184
76MP0002060_abnormal_skin_morphology1.19020290
77MP0000343_altered_response_to1.16945977
78MP0003806_abnormal_nucleotide_metabolis1.12777362
79MP0001851_eye_inflammation1.12653420
80MP0004782_abnormal_surfactant_physiolog1.12113121
81MP0005390_skeleton_phenotype1.10947548
82MP0004883_abnormal_blood_vessel1.10574204
83MP0005464_abnormal_platelet_physiology1.10232055
84MP0009780_abnormal_chondrocyte_physiolo1.09364991
85MP0002166_altered_tumor_susceptibility1.08882134
86MP0003566_abnormal_cell_adhesion1.08133129
87MP0001501_abnormal_sleep_pattern1.07691122
88MP0003329_amyloid_beta_deposits1.05839159
89MP0005164_abnormal_response_to1.04218383
90MP0003453_abnormal_keratinocyte_physiol1.00266877
91MP0005165_increased_susceptibility_to0.98302084
92MP0003221_abnormal_cardiomyocyte_apopto0.98017231
93MP0005620_abnormal_muscle_contractility0.96147211
94MP0003045_fibrosis0.94252017
95MP0000751_myopathy0.93505439
96MP0000750_abnormal_muscle_regeneration0.91900709
97MP0001544_abnormal_cardiovascular_syste0.91477423
98MP0005385_cardiovascular_system_phenoty0.91477423
99MP0005503_abnormal_tendon_morphology0.88172275
100MP0008961_abnormal_basal_metabolism0.87996012
101MP0010155_abnormal_intestine_physiology0.87826204
102MP0003646_muscle_fatigue0.87800100
103MP0005166_decreased_susceptibility_to0.87632513
104MP0002909_abnormal_adrenal_gland0.86993550
105MP0001727_abnormal_embryo_implantation0.86477390
106MP0003950_abnormal_plasma_membrane0.84431144
107MP0004087_abnormal_muscle_fiber0.83813111
108MP0000716_abnormal_immune_system0.83426533
109MP0000759_abnormal_skeletal_muscle0.81441001
110MP0009333_abnormal_splenocyte_physiolog0.81009896
111MP0002006_tumorigenesis0.80756469
112MP0001756_abnormal_urination0.80672157
113MP0005584_abnormal_enzyme/coenzyme_acti0.80379463
114MP0004858_abnormal_nervous_system0.78766590
115MP0004808_abnormal_hematopoietic_stem0.77000289
116MP0010234_abnormal_vibrissa_follicle0.76091992
117MP0002139_abnormal_hepatobiliary_system0.74775246
118MP0003948_abnormal_gas_homeostasis0.74428099
119MP0008260_abnormal_autophagy0.73314978
120MP0005319_abnormal_enzyme/_coenzyme0.73111602
121MP0001879_abnormal_lymphatic_vessel0.71857784
122MP0004147_increased_porphyrin_level0.71739547
123MP0008004_abnormal_stomach_pH0.71487713
124MP0001663_abnormal_digestive_system0.70449394
125MP0001177_atelectasis0.70239356
126MP0003953_abnormal_hormone_level0.70117047
127MP0002972_abnormal_cardiac_muscle0.69622222
128MP0006036_abnormal_mitochondrial_physio0.69617854
129MP0000249_abnormal_blood_vessel0.69511942
130MP0002168_other_aberrant_phenotype0.69333828
131MP0002638_abnormal_pupillary_reflex0.68985032
132MP0001764_abnormal_homeostasis0.68739555
133MP0002295_abnormal_pulmonary_circulatio0.68596576
134MP0009643_abnormal_urine_homeostasis0.68003130
135MP0001958_emphysema0.67571416
136MP0002332_abnormal_exercise_endurance0.65947657
137MP0005360_urolithiasis0.65298859
138MP0005332_abnormal_amino_acid0.62965566
139MP0005595_abnormal_vascular_smooth0.61804744
140MP0005388_respiratory_system_phenotype0.60723170
141MP0002133_abnormal_respiratory_system0.60723170
142MP0000230_abnormal_systemic_arterial0.59897721
143MP0005076_abnormal_cell_differentiation0.59771592
144MP0001533_abnormal_skeleton_physiology0.58809651
145MP0003448_altered_tumor_morphology0.55459878
146MP0005330_cardiomyopathy0.54144759
147MP0009763_increased_sensitivity_to0.53286335
148MP0009672_abnormal_birth_weight0.52922859
149MP0005058_abnormal_lysosome_morphology0.51353641
150MP0005167_abnormal_blood-brain_barrier0.49243779
151MP0005501_abnormal_skin_physiology0.49163772
152MP0005647_abnormal_sex_gland0.48551430
153MP0000427_abnormal_hair_cycle0.47113649
154MP0004036_abnormal_muscle_relaxation0.45573349
155MP0000627_abnormal_mammary_gland0.44141342
156MP0010630_abnormal_cardiac_muscle0.43846310
157MP0002998_abnormal_bone_remodeling0.43597117

Predicted human phenotypes

RankGene SetZ-score
1Oligomenorrhea (HP:0000876)8.86189000
2Acanthosis nigricans (HP:0000956)7.34459423
3Hypertriglyceridemia (HP:0002155)6.46899816
4Hyperglycinuria (HP:0003108)5.47274157
5Abnormality of liposaccharide metabolism (HP:0010968)5.13423247
6Abnormality of glycosphingolipid metabolism (HP:0004343)5.13423247
7Abnormality of glycolipid metabolism (HP:0010969)5.13423247
8Difficulty running (HP:0009046)4.75387803
9Abnormality of serine family amino acid metabolism (HP:0010894)4.58620312
10Abnormality of glycine metabolism (HP:0010895)4.58620312
11Insulin-resistant diabetes mellitus (HP:0000831)4.57305053
12Dysostosis multiplex (HP:0000943)4.11660102
13Eczematoid dermatitis (HP:0000976)3.95593590
14Axonal loss (HP:0003447)3.86301610
15Reduced subcutaneous adipose tissue (HP:0003758)3.80112759
16Myositis (HP:0100614)3.68980786
17Recurrent abscess formation (HP:0002722)3.65137684
18Increased connective tissue (HP:0009025)3.63834904
19Elevated erythrocyte sedimentation rate (HP:0003565)3.59654479
20Insulin resistance (HP:0000855)3.56716959
21Myoglobinuria (HP:0002913)3.56346951
22Pigmentary retinal degeneration (HP:0001146)3.53468860
23Abnormality of macrophages (HP:0004311)3.52704454
24Recurrent bacterial skin infections (HP:0005406)3.49741603
25Epidermoid cyst (HP:0200040)3.45012048
26Long foot (HP:0001833)3.41987717
27Increased cerebral lipofuscin (HP:0011813)3.41745381
28Multiple enchondromatosis (HP:0005701)3.40033450
29Growth hormone excess (HP:0000845)3.37244153
30Hypoalphalipoproteinemia (HP:0003233)3.34717957
31Orchitis (HP:0100796)3.33255270
32Subcapsular cataract (HP:0000523)3.32340690
33Increased muscle lipid content (HP:0009058)3.32217669
34Broad metatarsal (HP:0001783)3.31944249
35Myocardial infarction (HP:0001658)3.29941016
36Abnormality of proline metabolism (HP:0010907)3.24979958
37Hydroxyprolinuria (HP:0003080)3.24979958
38Loss of speech (HP:0002371)3.18205624
39Vacuolated lymphocytes (HP:0001922)3.17439266
40Hyperlipoproteinemia (HP:0010980)3.15109213
41Hemorrhage of the eye (HP:0011885)3.14884759
42Hypoglycemic coma (HP:0001325)3.14012970
43Ketoacidosis (HP:0001993)3.13381012
44Nausea (HP:0002018)3.09452973
45Ankle contracture (HP:0006466)3.09325718
46Abnormality of fatty-acid metabolism (HP:0004359)3.04740909
47Type 1 muscle fiber predominance (HP:0003803)3.04183482
48Bone cyst (HP:0012062)3.04083605
49Hepatosplenomegaly (HP:0001433)3.03337469
50Recurrent gram-negative bacterial infections (HP:0005420)3.03033867
51Mutism (HP:0002300)3.00340362
52Ketosis (HP:0001946)2.98476082
53Cerebral aneurysm (HP:0004944)2.97205667
54Abnormality of mucopolysaccharide metabolism (HP:0011020)2.91761956
55Abnormality of polysaccharide metabolism (HP:0011012)2.91761956
56Abnormality of glycosaminoglycan metabolism (HP:0004371)2.91761956
57Spontaneous hematomas (HP:0007420)2.85699501
58Asymmetric septal hypertrophy (HP:0001670)2.85044289
59Obstructive lung disease (HP:0006536)2.84247478
60Chronic obstructive pulmonary disease (HP:0006510)2.84247478
61Mediastinal lymphadenopathy (HP:0100721)2.82775600
62Increased neuronal autofluorescent lipopigment (HP:0002074)2.82211879
63Hyperglycinemia (HP:0002154)2.80969365
64Increased variability in muscle fiber diameter (HP:0003557)2.80475690
65Hyperthyroidism (HP:0000836)2.79666644
66Polycythemia (HP:0001901)2.78141266
67Urinary glycosaminoglycan excretion (HP:0003541)2.77233482
68Mucopolysacchariduria (HP:0008155)2.77233482
69Muscle fiber splitting (HP:0003555)2.73700878
70Spinal rigidity (HP:0003306)2.68700439
71Skin nodule (HP:0200036)2.67793467
72Large hands (HP:0001176)2.67216421
73Polyphagia (HP:0002591)2.65190379
74Xanthomatosis (HP:0000991)2.64043854
75Colitis (HP:0002583)2.62854209
76Glomerulonephritis (HP:0000099)2.61567072
77Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.60616296
78Optic neuritis (HP:0100653)2.60427447
79Retrobulbar optic neuritis (HP:0100654)2.60427447
80Rhabdomyolysis (HP:0003201)2.60154621
81Stomatitis (HP:0010280)2.60052294
82Increased IgE level (HP:0003212)2.59484953
83Abnormal cartilage morphology (HP:0002763)2.57205154
84Follicular hyperkeratosis (HP:0007502)2.55988770
85Systemic lupus erythematosus (HP:0002725)2.54894735
86Disinhibition (HP:0000734)2.54681759
87Thyroid-stimulating hormone excess (HP:0002925)2.54462187
88Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.52033173
89Hyperpituitarism (HP:0010514)2.51906165
90Gingivitis (HP:0000230)2.51851065
91Pancreatitis (HP:0001733)2.48900276
92Amyloidosis (HP:0011034)2.44471537
93Nuclear cataract (HP:0100018)2.43480074
94Purpura (HP:0000979)2.41068515
95Toxemia of pregnancy (HP:0100603)2.40720033
96Abnormality of skeletal muscle fiber size (HP:0012084)2.39455675
97Keratoconjunctivitis sicca (HP:0001097)2.38069760
98Increased serum ferritin (HP:0003281)2.38045995
99Hyperammonemia (HP:0001987)2.37978845
100Pulmonary infiltrates (HP:0002113)2.35914826
101Accelerated skeletal maturation (HP:0005616)2.35111116
102Abnormal hemoglobin (HP:0011902)2.34359279
103Hematochezia (HP:0002573)2.33950882
104* Abnormality of complement system (HP:0005339)2.33756968
105Vertebral compression fractures (HP:0002953)2.32061775
106Hypercholesterolemia (HP:0003124)2.31036478
107Hemoptysis (HP:0002105)2.30633276
108Hyporeflexia of lower limbs (HP:0002600)2.30519331
109Right ventricular cardiomyopathy (HP:0011663)2.29367287
110Facial diplegia (HP:0001349)2.28639404
111Decreased subcutaneous fat (HP:0001002)2.28108511
112Lipoatrophy (HP:0100578)2.26457382
113Malnutrition (HP:0004395)2.25830280
114Aortic aneurysm (HP:0004942)2.24835736
115Autoimmune thrombocytopenia (HP:0001973)2.23980712
116Enlarged penis (HP:0000040)2.23676962
117Polygenic inheritance (HP:0010982)2.23634651
118Cellulitis (HP:0100658)2.22936912
119Abnormality of the vasculature of the conjunctiva (HP:0008054)2.22634722
120Prenatal maternal abnormality (HP:0002686)2.21920976
121Abnormality of dicarboxylic acid metabolism (HP:0010995)2.21443568
122Dicarboxylic aciduria (HP:0003215)2.21443568
123Venous abnormality (HP:0002624)2.18648270
124Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.18537418
125Slender build (HP:0001533)2.17193922
126Hyperglycemia (HP:0003074)2.16503789
127Thrombocytosis (HP:0001894)2.15540941
128Progressive neurologic deterioration (HP:0002344)2.14862891
129Polar cataract (HP:0010696)2.13455948
130Tetraparesis (HP:0002273)2.13337718
131Keratoconjunctivitis (HP:0001096)2.13231794
132Aortic dissection (HP:0002647)2.12671121
133Petechiae (HP:0000967)2.12183108
134Meningitis (HP:0001287)2.12121278
135Prolonged bleeding time (HP:0003010)2.09851166
136Neurofibrillary tangles (HP:0002185)2.08727482
137Prominent supraorbital ridges (HP:0000336)2.07656810
138Vasculitis (HP:0002633)2.07113111
139Abnormality of purine metabolism (HP:0004352)2.06175675
140Shallow orbits (HP:0000586)2.06011026
141Muscle stiffness (HP:0003552)2.05274966
142Premature rupture of membranes (HP:0001788)2.04137458
143Recurrent skin infections (HP:0001581)2.03869147
144Inflammation of the large intestine (HP:0002037)2.03433443
145Joint stiffness (HP:0001387)2.02355864
146Hypercortisolism (HP:0001578)2.01789863
147Turricephaly (HP:0000262)2.00711843
148Neck muscle weakness (HP:0000467)2.00294902
149Abnormality of subcutaneous fat tissue (HP:0001001)2.00025941
150Abnormality of iron homeostasis (HP:0011031)1.99744276
151Myotonia (HP:0002486)1.99477728
152Abnormal eating behavior (HP:0100738)1.99049836
153Glomerulopathy (HP:0100820)1.98920501
154* Complement deficiency (HP:0004431)1.98103084
155Gastrointestinal inflammation (HP:0004386)1.95096762
156Hypergammaglobulinemia (HP:0010702)1.94988670
157Rectal prolapse (HP:0002035)1.94955793
158Chest pain (HP:0100749)1.94850107
159Ragged-red muscle fibers (HP:0003200)1.94445896
160Interstitial pulmonary disease (HP:0006530)1.92708954
161Stridor (HP:0010307)1.91629766
162Pathologic fracture (HP:0002756)1.90634968
163Recurrent fungal infections (HP:0002841)1.89711201
164Epistaxis (HP:0000421)1.85885680
165Episodic fever (HP:0001954)1.85685263
166Proximal amyotrophy (HP:0007126)1.85578643
167Protrusio acetabuli (HP:0003179)1.84455399
168Hypertensive crisis (HP:0100735)1.84384928
169Polyneuropathy (HP:0001271)1.83199211
170Urticaria (HP:0001025)1.81888064
171Aneurysm (HP:0002617)1.80386890
172Buphthalmos (HP:0000557)1.75049100
173Striae distensae (HP:0001065)1.74107548
174Ileus (HP:0002595)1.72412946
175Generalized aminoaciduria (HP:0002909)1.70438265
176Fibular hypoplasia (HP:0003038)1.69587561
177Ectopia lentis (HP:0001083)1.66892262
178Limb hypertonia (HP:0002509)1.66294423

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMK1D6.22855640
2TRIB35.54106640
3SIK14.59732189
4CAMK1G4.56930343
5BCKDK3.99567982
6RIPK43.28373781
7ERN12.72313891
8RIPK12.69645428
9PDK32.65646288
10PDK42.65646288
11LMTK22.54379075
12MST1R2.50992981
13BLK2.31588919
14MAP3K112.19038046
15TBK12.18905806
16NME22.15609002
17GRK72.09357959
18EPHB21.97547332
19MOS1.95336844
20KIT1.87653207
21MAP4K11.86962004
22FES1.83138358
23PRKAA21.79290478
24CDK91.77741085
25MAP3K31.64187802
26PRPF4B1.64076255
27TAOK11.63239745
28TAOK21.58875206
29INSRR1.57594864
30MAP3K141.54739842
31FGFR21.54240011
32PDK21.51013757
33FGFR31.45607363
34PKN21.42929265
35TESK11.41721512
36ARAF1.40222875
37ZAP701.38617628
38PDGFRA1.34604204
39MAPK41.31739987
40PIM21.31143612
41IRAK41.30061230
42TGFBR21.26274511
43IKBKB1.24122342
44PIK3CA1.23606110
45MAP2K11.21457987
46CDK61.20052151
47FRK1.19779522
48TTN1.14068901
49MAP3K11.11200756
50FGFR41.09119697
51BTK1.09047851
52MET1.08628242
53DDR21.08172426
54IKBKE1.07701380
55PHKG11.07061451
56PHKG21.07061451
57TIE11.04864971
58MYLK1.02702710
59PRKD31.01296775
60SYK0.99616444
61GRK50.97533443
62JAK10.95694885
63LYN0.95454048
64FER0.94674252
65MAPK70.93667066
66MAP3K60.92524153
67KDR0.91707722
68HCK0.90926342
69LATS10.90864881
70CDC42BPA0.88540749
71PRKAA10.88032572
72MATK0.87712996
73JAK20.81104486
74DAPK20.79678404
75FGR0.78481891
76PDPK10.74701665
77RET0.70998871
78PRKCH0.70839883
79KSR20.69313636
80LCK0.69037686
81ILK0.68681247
82LATS20.68039255
83MAPK150.67789008
84IGF1R0.65509059
85PDGFRB0.63212901
86GSK3A0.61567212
87MTOR0.60975862
88MARK30.60345400
89TXK0.60309655
90EEF2K0.59354238
91BMPR20.58975026
92GRK60.58058423
93RPS6KL10.57926450
94RPS6KC10.57926450
95FLT30.57184843
96JAK30.57152335
97NEK90.57057374
98MAPK110.56921774
99EPHB10.56479106
100CSK0.56396612
101PRKD10.56253124
102PKN10.55519352
103PRKACG0.55297428
104CAMKK20.54209277
105CAMK10.54023970
106PDK10.53760761
107PAK20.53541659
108BMX0.53460182
109HIPK20.52507698
110PTK2B0.52043682
111FGFR10.50601331
112TGFBR10.50252934
113TEC0.49665900
114IRAK30.49353600
115INSR0.48890403
116MAP2K20.48447289
117CDK40.48216631
118SIK30.47442682
119RPS6KA60.45237799
120TESK20.44009828
121MAPKAPK20.43530604
122PRKD20.42625568
123MAP2K30.41822198
124MAPKAPK30.41764207
125MAPK30.40651570
126STK100.40289777
127LRRK20.39242033
128PINK10.39189021
129MAP2K40.39069687
130MAPK120.39047784
131TNK20.38147819
132MAP2K60.38124245
133IRAK10.37546126
134DAPK30.36993337
135SRC0.35560781
136PTK60.35249954
137MAP3K130.33613304
138TYRO30.32601803
139EPHA30.31404385
140PRKG20.28933073
141ABL20.28384713
142IRAK20.26801366
143PIK3CG0.24725109
144RPS6KB10.23629506
145MARK20.23557850
146CSF1R0.20713089
147DMPK0.20541107
148STK30.20157180
149EIF2AK20.18081856
150OBSCN0.18025652
151TYK20.17709352
152ABL10.15651722
153TRPM70.15491035

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.66825031
2Regulation of lipolysis in adipocytes_Homo sapiens_hsa049234.64742852
3PPAR signaling pathway_Homo sapiens_hsa033204.59335850
4Propanoate metabolism_Homo sapiens_hsa006404.49899262
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.67942444
6Other glycan degradation_Homo sapiens_hsa005113.51638823
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.36380293
8Fatty acid metabolism_Homo sapiens_hsa012123.15592817
9Glycerolipid metabolism_Homo sapiens_hsa005613.05319041
10Osteoclast differentiation_Homo sapiens_hsa043802.72456611
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.67163629
12Fatty acid degradation_Homo sapiens_hsa000712.55200684
13Malaria_Homo sapiens_hsa051442.52712000
14Pyruvate metabolism_Homo sapiens_hsa006202.29942188
15Glycosaminoglycan degradation_Homo sapiens_hsa005312.27203962
16Caffeine metabolism_Homo sapiens_hsa002322.26612270
17Leishmaniasis_Homo sapiens_hsa051402.25454767
18Adipocytokine signaling pathway_Homo sapiens_hsa049202.15932909
19beta-Alanine metabolism_Homo sapiens_hsa004102.11648322
20Rheumatoid arthritis_Homo sapiens_hsa053232.11054601
21Asthma_Homo sapiens_hsa053102.10255616
22AMPK signaling pathway_Homo sapiens_hsa041522.05733960
23Cyanoamino acid metabolism_Homo sapiens_hsa004602.01517660
24Nitrogen metabolism_Homo sapiens_hsa009101.97373491
25Allograft rejection_Homo sapiens_hsa053301.96114857
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.91183366
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.88282596
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.87687244
29Carbon metabolism_Homo sapiens_hsa012001.71301044
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.69187712
31Fat digestion and absorption_Homo sapiens_hsa049751.68353298
32Graft-versus-host disease_Homo sapiens_hsa053321.67987656
33Tuberculosis_Homo sapiens_hsa051521.59711242
34TNF signaling pathway_Homo sapiens_hsa046681.52279619
35Peroxisome_Homo sapiens_hsa041461.46659772
36Phenylalanine metabolism_Homo sapiens_hsa003601.44517554
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.40079194
38Insulin resistance_Homo sapiens_hsa049311.33231506
39Phagosome_Homo sapiens_hsa041451.30068544
40Hematopoietic cell lineage_Homo sapiens_hsa046401.26563507
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.26413814
42Butanoate metabolism_Homo sapiens_hsa006501.25656319
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.25090314
44Insulin signaling pathway_Homo sapiens_hsa049101.23874262
45Renin-angiotensin system_Homo sapiens_hsa046141.23593447
46Tyrosine metabolism_Homo sapiens_hsa003501.22355319
47NOD-like receptor signaling pathway_Homo sapiens_hsa046211.20957367
48Salmonella infection_Homo sapiens_hsa051321.17184772
49African trypanosomiasis_Homo sapiens_hsa051431.16472446
50B cell receptor signaling pathway_Homo sapiens_hsa046621.14895328
51Antigen processing and presentation_Homo sapiens_hsa046121.12474162
52Vitamin B6 metabolism_Homo sapiens_hsa007501.11954647
53Type I diabetes mellitus_Homo sapiens_hsa049401.10010900
54Longevity regulating pathway - mammal_Homo sapiens_hsa042111.08359623
55Jak-STAT signaling pathway_Homo sapiens_hsa046301.07888242
56Viral myocarditis_Homo sapiens_hsa054161.05899861
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.04692444
58Influenza A_Homo sapiens_hsa051641.01606842
59Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.01170571
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.98692478
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97205735
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.96803344
63Legionellosis_Homo sapiens_hsa051340.95979149
64Chemokine signaling pathway_Homo sapiens_hsa040620.93260594
65Renin secretion_Homo sapiens_hsa049240.91182484
66Glucagon signaling pathway_Homo sapiens_hsa049220.91120382
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.90312608
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89230337
69Pentose phosphate pathway_Homo sapiens_hsa000300.89061055
70Fatty acid elongation_Homo sapiens_hsa000620.87902128
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.85797623
72Tryptophan metabolism_Homo sapiens_hsa003800.83548727
73Histidine metabolism_Homo sapiens_hsa003400.83052259
74Folate biosynthesis_Homo sapiens_hsa007900.81536736
75Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.81520013
76Type II diabetes mellitus_Homo sapiens_hsa049300.80236076
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79764737
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.79357013
79ECM-receptor interaction_Homo sapiens_hsa045120.77478621
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76094219
81Herpes simplex infection_Homo sapiens_hsa051680.74618855
82Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.72855361
83Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72102425
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.68918675
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.65766023
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62155228
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59765771
88Measles_Homo sapiens_hsa051620.58790124
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57811439
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57545642
91Protein digestion and absorption_Homo sapiens_hsa049740.54951966
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53586334
93Apoptosis_Homo sapiens_hsa042100.53531044
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51967772
95Primary immunodeficiency_Homo sapiens_hsa053400.51395427
96Focal adhesion_Homo sapiens_hsa045100.51265765
97Biosynthesis of amino acids_Homo sapiens_hsa012300.47750282
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47108421
99Arginine biosynthesis_Homo sapiens_hsa002200.46866028
100ABC transporters_Homo sapiens_hsa020100.46634097
101Acute myeloid leukemia_Homo sapiens_hsa052210.45434517
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43455790
103HTLV-I infection_Homo sapiens_hsa051660.42724331
104Prolactin signaling pathway_Homo sapiens_hsa049170.42407996
105HIF-1 signaling pathway_Homo sapiens_hsa040660.42355229
106Starch and sucrose metabolism_Homo sapiens_hsa005000.42147390
107Hepatitis B_Homo sapiens_hsa051610.41592998
108mTOR signaling pathway_Homo sapiens_hsa041500.41085782
109Shigellosis_Homo sapiens_hsa051310.40953432
110* Staphylococcus aureus infection_Homo sapiens_hsa051500.40549229
111T cell receptor signaling pathway_Homo sapiens_hsa046600.38185379
112Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36828123
113Thyroid cancer_Homo sapiens_hsa052160.36393717
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34844363
115Linoleic acid metabolism_Homo sapiens_hsa005910.34730074
116Notch signaling pathway_Homo sapiens_hsa043300.34575842
117Proteoglycans in cancer_Homo sapiens_hsa052050.33072597
118Primary bile acid biosynthesis_Homo sapiens_hsa001200.32798756
119Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32570531
120Fructose and mannose metabolism_Homo sapiens_hsa000510.31142925
121cAMP signaling pathway_Homo sapiens_hsa040240.31071383
122Lysine degradation_Homo sapiens_hsa003100.30900859
123cGMP-PKG signaling pathway_Homo sapiens_hsa040220.30640870
124Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.30581339
125Sulfur relay system_Homo sapiens_hsa041220.30479902
126Sulfur metabolism_Homo sapiens_hsa009200.29101273
127Chemical carcinogenesis_Homo sapiens_hsa052040.26599191
128Arachidonic acid metabolism_Homo sapiens_hsa005900.26339040
129Glutathione metabolism_Homo sapiens_hsa004800.24828434
130Melanoma_Homo sapiens_hsa052180.23898219
131Autoimmune thyroid disease_Homo sapiens_hsa053200.23671769
132AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.23347967
133Amoebiasis_Homo sapiens_hsa051460.22639828
134Lysosome_Homo sapiens_hsa041420.20802349
135PI3K-Akt signaling pathway_Homo sapiens_hsa041510.19928199
136Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.19519414
137Pentose and glucuronate interconversions_Homo sapiens_hsa000400.17740052
138* Complement and coagulation cascades_Homo sapiens_hsa046100.16918814
139Small cell lung cancer_Homo sapiens_hsa052220.16780212
140Salivary secretion_Homo sapiens_hsa049700.16611533
141Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.13966853
142Toxoplasmosis_Homo sapiens_hsa051450.12357472
143FoxO signaling pathway_Homo sapiens_hsa040680.12305718
144Prion diseases_Homo sapiens_hsa050200.12153220
145Metabolic pathways_Homo sapiens_hsa011000.10847350
146Thyroid hormone synthesis_Homo sapiens_hsa049180.10111954
147Ovarian steroidogenesis_Homo sapiens_hsa049130.08863047
148VEGF signaling pathway_Homo sapiens_hsa043700.08506928
149Vascular smooth muscle contraction_Homo sapiens_hsa042700.07944759
150Hepatitis C_Homo sapiens_hsa051600.07906043
151Platelet activation_Homo sapiens_hsa046110.07471974
152Phospholipase D signaling pathway_Homo sapiens_hsa040720.07420082
153Aldosterone synthesis and secretion_Homo sapiens_hsa049250.06722003
154Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.06377002
155Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.05971170
156Sphingolipid signaling pathway_Homo sapiens_hsa040710.05620513
157Pertussis_Homo sapiens_hsa051330.04151919
158Glioma_Homo sapiens_hsa052140.04082129

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