CFHR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted protein belonging to the complement factor H protein family. It binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. It is proposed that Tuf acts as a virulence factor by acquiring host proteins to the pathogen surface, controlling complement, and facilitating tissue invasion. Mutations in this gene are associated with an increased risk of atypical hemolytic-uremic syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)8.03700789
2epoxygenase P450 pathway (GO:0019373)8.00835097
3omega-hydroxylase P450 pathway (GO:0097267)7.73865700
4L-phenylalanine catabolic process (GO:0006559)7.65919196
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.65919196
6L-phenylalanine metabolic process (GO:0006558)7.29809138
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.29809138
8aromatic amino acid family catabolic process (GO:0009074)6.96963944
9tryptophan catabolic process (GO:0006569)6.34996728
10indole-containing compound catabolic process (GO:0042436)6.34996728
11indolalkylamine catabolic process (GO:0046218)6.34996728
12oxidative demethylation (GO:0070989)6.25202697
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.23796700
14kynurenine metabolic process (GO:0070189)6.16713976
15bile acid biosynthetic process (GO:0006699)6.10662092
16drug metabolic process (GO:0017144)6.02313035
17tryptophan metabolic process (GO:0006568)5.97661098
18glyoxylate metabolic process (GO:0046487)5.80237473
19urea metabolic process (GO:0019627)5.79250585
20urea cycle (GO:0000050)5.79250585
21negative regulation of fibrinolysis (GO:0051918)5.60068792
22complement activation, alternative pathway (GO:0006957)5.55444673
23phenylpropanoid metabolic process (GO:0009698)5.52794251
24high-density lipoprotein particle remodeling (GO:0034375)5.50776518
25regulation of protein activation cascade (GO:2000257)5.47811509
26alpha-linolenic acid metabolic process (GO:0036109)5.45824831
27regulation of fibrinolysis (GO:0051917)5.43999969
28protein carboxylation (GO:0018214)5.41384789
29peptidyl-glutamic acid carboxylation (GO:0017187)5.41384789
30cysteine metabolic process (GO:0006534)5.39597700
31sulfur amino acid catabolic process (GO:0000098)5.37561020
32nitrogen cycle metabolic process (GO:0071941)5.32733630
33bile acid metabolic process (GO:0008206)5.20037975
34serine family amino acid catabolic process (GO:0009071)5.18595611
35regulation of complement activation (GO:0030449)5.13794611
36aromatic amino acid family metabolic process (GO:0009072)5.06265361
37negative regulation of protein activation cascade (GO:2000258)4.97585866
38homocysteine metabolic process (GO:0050667)4.91814834
39fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.89477390
40ethanol metabolic process (GO:0006067)4.89250464
41tyrosine metabolic process (GO:0006570)4.89097392
42regulation of humoral immune response (GO:0002920)4.88818387
43alkaloid metabolic process (GO:0009820)4.82206905
44regulation of plasminogen activation (GO:0010755)4.81196717
45regulation of triglyceride catabolic process (GO:0010896)4.81099406
46regulation of cholesterol esterification (GO:0010872)4.78976459
47reverse cholesterol transport (GO:0043691)4.77584014
48acute-phase response (GO:0006953)4.76445483
49alpha-amino acid catabolic process (GO:1901606)4.72420850
50S-adenosylmethionine metabolic process (GO:0046500)4.72403767
51plasma lipoprotein particle remodeling (GO:0034369)4.71483166
52protein-lipid complex remodeling (GO:0034368)4.71483166
53macromolecular complex remodeling (GO:0034367)4.71483166
54negative regulation of hemostasis (GO:1900047)4.68158080
55negative regulation of blood coagulation (GO:0030195)4.68158080
56amino-acid betaine metabolic process (GO:0006577)4.64216280
57lysine catabolic process (GO:0006554)4.62446205
58lysine metabolic process (GO:0006553)4.62446205
59hormone catabolic process (GO:0042447)4.61082658
60acylglycerol homeostasis (GO:0055090)4.59359981
61triglyceride homeostasis (GO:0070328)4.59359981
62indolalkylamine metabolic process (GO:0006586)4.51427470
63negative regulation of cholesterol transport (GO:0032375)4.50573089
64negative regulation of sterol transport (GO:0032372)4.50573089
65glycine metabolic process (GO:0006544)4.48910617
66bile acid and bile salt transport (GO:0015721)4.48782579
67imidazole-containing compound metabolic process (GO:0052803)4.48260784
68phospholipid efflux (GO:0033700)4.48076204
69coenzyme catabolic process (GO:0009109)4.45995817
70amine catabolic process (GO:0009310)4.42656664
71cellular biogenic amine catabolic process (GO:0042402)4.42656664
72cellular glucuronidation (GO:0052695)4.42462895
73cellular ketone body metabolic process (GO:0046950)4.40323545
74negative regulation of wound healing (GO:0061045)4.34218284
75cellular amino acid catabolic process (GO:0009063)4.33332765
76plasma lipoprotein particle clearance (GO:0034381)4.29621372
77positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.29443902
78glutamate metabolic process (GO:0006536)4.25095588
79negative regulation of coagulation (GO:0050819)4.24733433
80serine family amino acid metabolic process (GO:0009069)4.23666381
81cholesterol efflux (GO:0033344)4.17857470
82benzene-containing compound metabolic process (GO:0042537)4.17499317
83ethanol oxidation (GO:0006069)4.12673097
84aldehyde catabolic process (GO:0046185)4.10892490
85arginine metabolic process (GO:0006525)4.08621505
86negative regulation of complement activation (GO:0045916)4.07884493
87serine family amino acid biosynthetic process (GO:0009070)4.05449144
88dicarboxylic acid biosynthetic process (GO:0043650)4.04792530
89cellular modified amino acid catabolic process (GO:0042219)4.04662204
90low-density lipoprotein particle remodeling (GO:0034374)4.03829703
91fibrinolysis (GO:0042730)4.03268125
92flavonoid metabolic process (GO:0009812)3.97480446
93uronic acid metabolic process (GO:0006063)3.93089927
94glucuronate metabolic process (GO:0019585)3.93089927
95drug catabolic process (GO:0042737)3.92570823
96plasma lipoprotein particle assembly (GO:0034377)3.92511331
97positive regulation of blood coagulation (GO:0030194)3.92134015
98positive regulation of hemostasis (GO:1900048)3.92134015
99blood coagulation, intrinsic pathway (GO:0007597)3.90279773
100complement activation, classical pathway (GO:0006958)3.89025009
101steroid catabolic process (GO:0006706)3.87399620
102regulation of lipoprotein particle clearance (GO:0010984)3.86787781
103heme transport (GO:0015886)3.86576306
104cofactor catabolic process (GO:0051187)3.85391255
105cytolysis (GO:0019835)3.84317479
106regulation of bile acid biosynthetic process (GO:0070857)3.82389583
107ketone body metabolic process (GO:1902224)3.81028846
108carboxylic acid catabolic process (GO:0046395)3.77614505
109organic acid catabolic process (GO:0016054)3.77614505
110very-low-density lipoprotein particle assembly (GO:0034379)3.75353066
111acute inflammatory response (GO:0002526)3.73472599
112cholesterol homeostasis (GO:0042632)3.72133360
113negative regulation of lipase activity (GO:0060192)3.72087538
114* protein activation cascade (GO:0072376)3.71186659
115phospholipid homeostasis (GO:0055091)3.70936146
116positive regulation of triglyceride lipase activity (GO:0061365)3.70548589
117positive regulation of lipoprotein lipase activity (GO:0051006)3.70548589
118positive regulation of lipid catabolic process (GO:0050996)3.69956413
119* complement activation (GO:0006956)3.69465655
120acetyl-CoA metabolic process (GO:0006084)3.69166064
121disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.68249217
122killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.68249217
123NAD biosynthetic process (GO:0009435)3.66295786
124sterol homeostasis (GO:0055092)3.65860718
125short-chain fatty acid metabolic process (GO:0046459)3.65566422
126pyridine nucleotide biosynthetic process (GO:0019363)3.58936620
127nicotinamide nucleotide biosynthetic process (GO:0019359)3.58936620
128arginine catabolic process (GO:0006527)3.58446910
129positive regulation of coagulation (GO:0050820)3.57811103
130plasma lipoprotein particle organization (GO:0071827)3.57712343
131xenobiotic metabolic process (GO:0006805)3.55389849
132regulation of acute inflammatory response (GO:0002673)3.54600260
133opsonization (GO:0008228)3.52862810

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.40408287
2EGR1_23403033_ChIP-Seq_LIVER_Mouse7.26130002
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.16241390
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.50695444
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.31330305
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.19431200
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.66386735
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.09482519
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.05873007
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.08949533
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9936096
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.94876872
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89299203
14HTT_18923047_ChIP-ChIP_STHdh_Human1.65650265
15FOXA2_19822575_ChIP-Seq_HepG2_Human1.57418304
16GATA1_22025678_ChIP-Seq_K562_Human1.44038786
17CLOCK_20551151_ChIP-Seq_293T_Human1.41705675
18HNF4A_19822575_ChIP-Seq_HepG2_Human1.39584992
19* NFE2_27457419_Chip-Seq_LIVER_Mouse1.26321921
20RXRA_24833708_ChIP-Seq_LIVER_Mouse1.21184857
21ER_23166858_ChIP-Seq_MCF-7_Human1.21101565
22CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.19967920
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.19850255
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18195758
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.15373235
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.14867053
27GBX2_23144817_ChIP-Seq_PC3_Human1.14375565
28HNFA_21074721_ChIP-Seq_CACO-2_Human1.13041311
29* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.12270336
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10931877
31ESR1_20079471_ChIP-ChIP_T-47D_Human1.10334431
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.09569911
33PIAS1_25552417_ChIP-Seq_VCAP_Human1.07689468
34* EZH2_27294783_Chip-Seq_NPCs_Mouse1.07342084
35* GATA6_21074721_ChIP-Seq_CACO-2_Human1.06014007
36* PHF8_20622853_ChIP-Seq_HELA_Human1.05452559
37ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00967408
38* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00383910
39TRIM28_21343339_ChIP-Seq_HEK293_Human0.99211939
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98861348
41NFYA_21822215_ChIP-Seq_K562_Human0.98233478
42ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96627583
43ETV2_25802403_ChIP-Seq_MESCs_Mouse0.93808700
44GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92915577
45IRF8_22096565_ChIP-ChIP_GC-B_Human0.92713917
46IGF1R_20145208_ChIP-Seq_DFB_Human0.92228855
47SOX2_27498859_Chip-Seq_STOMACH_Mouse0.87133249
48ETV1_20927104_ChIP-Seq_GIST48_Human0.87053028
49EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.86967992
50CBX2_22325352_ChIP-Seq_293T-Rex_Human0.86428612
51KAP1_22055183_ChIP-Seq_ESCs_Mouse0.85323466
52TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.85276258
53AUTS2_25519132_ChIP-Seq_293T-REX_Human0.85003588
54PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.82879392
55SOX2_21211035_ChIP-Seq_LN229_Human0.82141357
56CTBP1_25329375_ChIP-Seq_LNCAP_Human0.79999584
57GATA4_25053715_ChIP-Seq_YYC3_Human0.77747821
58SOX2_19829295_ChIP-Seq_ESCs_Human0.77471147
59NANOG_19829295_ChIP-Seq_ESCs_Human0.77471147
60Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.77221657
61NFYB_21822215_ChIP-Seq_K562_Human0.77078307
62* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.76819979
63TP53_18474530_ChIP-ChIP_U2OS_Human0.76803486
64RBPJ_21746931_ChIP-Seq_IB4_Human0.75964707
65RAC3_21632823_ChIP-Seq_H3396_Human0.75934510
66ERA_21632823_ChIP-Seq_H3396_Human0.75821983
67BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.75586085
68MYC_19829295_ChIP-Seq_ESCs_Human0.75425445
69ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.75058414
70PCGF2_27294783_Chip-Seq_NPCs_Mouse0.74505019
71FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.74456625
72RARA_24833708_ChIP-Seq_LIVER_Mouse0.74427892
73SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.72850870
74FOXA1_25329375_ChIP-Seq_VCAP_Human0.72418157
75FOXA1_27270436_Chip-Seq_PROSTATE_Human0.72418157
76PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.72371098
77SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.71817341
78ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.71615061
79RARG_19884340_ChIP-ChIP_MEFs_Mouse0.71307165
80* NCOR_22424771_ChIP-Seq_293T_Human0.71089072
81GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.70704473
82CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.69508413
83* RUNX1_27457419_Chip-Seq_LIVER_Mouse0.69443924
84GATA3_21878914_ChIP-Seq_MCF-7_Human0.68404376
85NRF2_20460467_ChIP-Seq_MEFs_Mouse0.68013129
86NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.68013129
87* OCT4_18555785_Chip-Seq_ESCs_Mouse0.67834554
88* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.67355134
89E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.66423379
90TCF4_18268006_ChIP-ChIP_LS174T_Human0.66160511
91AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.65780967
92SALL4_18804426_ChIP-ChIP_XEN_Mouse0.65200185
93KLF5_20875108_ChIP-Seq_MESCs_Mouse0.64746713
94RARB_24833708_ChIP-Seq_LIVER_Mouse0.63677907
95* ESRRB_18555785_Chip-Seq_ESCs_Mouse0.63660597
96FOXA1_21572438_ChIP-Seq_LNCaP_Human0.62470765
97RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.61993270
98RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61901506
99BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.61243679
100TAF15_26573619_Chip-Seq_HEK293_Human0.60410422
101CEBPB_22108803_ChIP-Seq_LS180_Human0.57441606
102ZNF263_19887448_ChIP-Seq_K562_Human0.57341928
103EGR1_19032775_ChIP-ChIP_M12_Human0.57337865
104ESR2_21235772_ChIP-Seq_MCF-7_Human0.57023875
105AR_20517297_ChIP-Seq_VCAP_Human0.55904916
106NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.54856937
107NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.54062740
108NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.53991884
109PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.52745810
110FOXA1_25552417_ChIP-Seq_VCAP_Human0.52304968
111FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.51710706
112MYC_19915707_ChIP-ChIP_AK7_Human0.51383414
113* STAT1_17558387_ChIP-Seq_HELA_Human0.51101501
114FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.50430091
115CBP_21632823_ChIP-Seq_H3396_Human0.50275759
116* ESET_19884257_ChIP-Seq_ESCs_Mouse0.48051473
117P53_21459846_ChIP-Seq_SAOS-2_Human0.47001821
118PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.46173161
119STAT3_1855785_ChIP-Seq_MESCs_Mouse0.46119379
120* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.45945378
121GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.45793616
122PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.44207919
123CDX2_20551321_ChIP-Seq_CACO-2_Human0.42970159
124BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.42676850
125BCAT_22108803_ChIP-Seq_LS180_Human0.41862621
126TAF2_19829295_ChIP-Seq_ESCs_Human0.40953470
127* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.40642137
128LXR_22292898_ChIP-Seq_THP-1_Human0.40342692
129PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.40084766
130ESR1_21235772_ChIP-Seq_MCF-7_Human0.39954780
131FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.39747198
132IRF1_19129219_ChIP-ChIP_H3396_Human0.39477245
133FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.38143883
134SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.37899436
135GATA1_19941827_ChIP-Seq_MEL_Mouse0.37603548
136EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.36712941
137MYC_27129775_Chip-Seq_CORNEA_Mouse0.36217756
138FOXH1_21741376_ChIP-Seq_EPCs_Human0.36070701
139STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.36023611
140SPI1_26923725_Chip-Seq_HPCs_Mouse0.35779409
141LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.35777078
142CDX2_22108803_ChIP-Seq_LS180_Human0.35267825
143FOXO3_23340844_ChIP-Seq_DLD1_Human0.35046094
144GATA2_19941826_ChIP-Seq_K562_Human0.34497347
145PPAR_26484153_Chip-Seq_NCI-H1993_Human0.34411265
146ERG_21242973_ChIP-ChIP_JURKAT_Human0.34361876
147* CRX_20693478_ChIP-Seq_RETINA_Mouse0.34051555
148ERG_20517297_ChIP-Seq_VCAP_Human0.34040413

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.32431968
2MP0005360_urolithiasis7.64308472
3MP0005085_abnormal_gallbladder_physiolo6.55346709
4MP0005365_abnormal_bile_salt6.19784933
5MP0008875_abnormal_xenobiotic_pharmacok5.23024258
6MP0003806_abnormal_nucleotide_metabolis4.35852203
7MP0003252_abnormal_bile_duct3.94913187
8MP0010329_abnormal_lipoprotein_level3.55431583
9MP0009840_abnormal_foam_cell3.15585237
10MP0005083_abnormal_biliary_tract2.98556711
11MP0003195_calcinosis2.85667368
12MP0005332_abnormal_amino_acid2.75699087
13MP0001666_abnormal_nutrient_absorption2.58621017
14MP0003191_abnormal_cellular_cholesterol2.20944468
15MP0000609_abnormal_liver_physiology2.14385483
16MP0004019_abnormal_vitamin_homeostasis2.13864394
17MP0002118_abnormal_lipid_homeostasis2.08029595
18MP0002138_abnormal_hepatobiliary_system1.99837658
19MP0003868_abnormal_feces_composition1.98381303
20MP0005319_abnormal_enzyme/_coenzyme1.83093835
21MP0001764_abnormal_homeostasis1.72439604
22MP0009697_abnormal_copulation1.67391083
23MP0005584_abnormal_enzyme/coenzyme_acti1.56025744
24MP0005451_abnormal_body_composition1.38925883
25MP0003011_delayed_dark_adaptation1.35686294
26MP0003186_abnormal_redox_activity1.30486335
27MP0003656_abnormal_erythrocyte_physiolo1.25004521
28MP0009643_abnormal_urine_homeostasis1.20666415
29MP0000598_abnormal_liver_morphology1.17198419
30MP0005647_abnormal_sex_gland1.15907892
31MP0009764_decreased_sensitivity_to1.10917816
32MP0005187_abnormal_penis_morphology1.06346742
33MP0009763_increased_sensitivity_to1.03246629
34MP0003705_abnormal_hypodermis_morpholog1.02175777
35MP0000604_amyloidosis1.00669597
36MP0002254_reproductive_system_inflammat0.99028482
37MP0010368_abnormal_lymphatic_system0.93190393
38MP0008469_abnormal_protein_level0.90883082
39MP0005636_abnormal_mineral_homeostasis0.89521787
40MP0005408_hypopigmentation0.86803597
41MP0009642_abnormal_blood_homeostasis0.86586906
42MP0005670_abnormal_white_adipose0.83876322
43MP0006036_abnormal_mitochondrial_physio0.82538117
44MP0009765_abnormal_xenobiotic_induced0.81041790
45MP0002876_abnormal_thyroid_physiology0.80780001
46MP0005376_homeostasis/metabolism_phenot0.80407852
47MP0002282_abnormal_trachea_morphology0.76520875
48MP0005084_abnormal_gallbladder_morpholo0.76282069
49MP0002078_abnormal_glucose_homeostasis0.75750974
50MP0005220_abnormal_exocrine_pancreas0.72422905
51MP0002971_abnormal_brown_adipose0.69155747
52MP0005535_abnormal_body_temperature0.68494189
53MP0003879_abnormal_hair_cell0.67862876
54MP0004130_abnormal_muscle_cell0.67624860
55MP0005334_abnormal_fat_pad0.67593634
56MP0010386_abnormal_urinary_bladder0.67151868
57MP0001661_extended_life_span0.67131121
58MP0005266_abnormal_metabolism0.66046735
59MP0003690_abnormal_glial_cell0.65196069
60MP0001915_intracranial_hemorrhage0.64817899
61MP0009053_abnormal_anal_canal0.62600885
62MP0000566_synostosis0.60743327
63MP0000639_abnormal_adrenal_gland0.59233980
64MP0006035_abnormal_mitochondrial_morpho0.57329447
65MP0009785_altered_susceptibility_to0.55559048
66MP0002249_abnormal_larynx_morphology0.55204848
67MP0001756_abnormal_urination0.54331529
68MP0005448_abnormal_energy_balance0.53502080
69MP0003329_amyloid_beta_deposits0.53052523
70MP0005464_abnormal_platelet_physiology0.52125026
71MP0002822_catalepsy0.50623055
72MP0004782_abnormal_surfactant_physiolog0.49328032
73MP0004381_abnormal_hair_follicle0.48400554
74MP0003718_maternal_effect0.48032605
75MP0005395_other_phenotype0.47459651
76MP0003724_increased_susceptibility_to0.46510917
77MP0008874_decreased_physiological_sensi0.46451361
78MP0003436_decreased_susceptibility_to0.45533407
79MP0002928_abnormal_bile_duct0.45464511
80MP0003638_abnormal_response/metabolism_0.45438764
81MP0008873_increased_physiological_sensi0.45275012
82MP0005248_abnormal_Harderian_gland0.44987655
83MP0002136_abnormal_kidney_physiology0.43080721
84MP0005645_abnormal_hypothalamus_physiol0.42208698
85MP0003959_abnormal_lean_body0.40625054
86MP0001986_abnormal_taste_sensitivity0.40402391
87MP0004142_abnormal_muscle_tone0.40008555
88MP0003953_abnormal_hormone_level0.39434487
89MP0005166_decreased_susceptibility_to0.39099078
90MP0008872_abnormal_physiological_respon0.38945916
91MP0003075_altered_response_to0.37984027
92MP0000579_abnormal_nail_morphology0.37247909
93MP0002837_dystrophic_cardiac_calcinosis0.37069440
94MP0005551_abnormal_eye_electrophysiolog0.36747522
95MP0006082_CNS_inflammation0.35862721
96MP0009672_abnormal_birth_weight0.35410518
97MP0005666_abnormal_adipose_tissue0.32046696
98MP0009115_abnormal_fat_cell0.30969615
99MP0000230_abnormal_systemic_arterial0.30915388
100MP0000249_abnormal_blood_vessel0.30247694
101MP0002132_abnormal_respiratory_system0.29907891
102MP0001243_abnormal_dermal_layer0.29890217
103MP0001853_heart_inflammation0.29794850
104MP0005167_abnormal_blood-brain_barrier0.29483385
105MP0002796_impaired_skin_barrier0.29243281
106MP0001845_abnormal_inflammatory_respons0.28867645
107MP0002168_other_aberrant_phenotype0.28036735
108MP0009384_cardiac_valve_regurgitation0.28019849
109MP0002970_abnormal_white_adipose0.27444909
110MP0001881_abnormal_mammary_gland0.26860555
111MP0004883_abnormal_blood_vessel0.26535735
112MP0002332_abnormal_exercise_endurance0.25711054
113MP0001324_abnormal_eye_pigmentation0.24138549
114MP0002060_abnormal_skin_morphology0.23892009
115MP0002090_abnormal_vision0.23024660
116MP0005023_abnormal_wound_healing0.22638184
117MP0001440_abnormal_grooming_behavior0.22331936
118MP0005164_abnormal_response_to0.21987814
119MP0003633_abnormal_nervous_system0.21922597
120MP0005197_abnormal_uvea_morphology0.21891904
121MP0004043_abnormal_pH_regulation0.21614788
122MP0000467_abnormal_esophagus_morphology0.20672160
123MP0001944_abnormal_pancreas_morphology0.20565335
124MP0003632_abnormal_nervous_system0.20309696
125MP0005646_abnormal_pituitary_gland0.19386212

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.46702861
2Deep venous thrombosis (HP:0002625)7.46494506
3Abnormality of aromatic amino acid family metabolism (HP:0004338)7.45137872
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.76250306
5Prolonged partial thromboplastin time (HP:0003645)6.73536417
6Hypobetalipoproteinemia (HP:0003563)6.46528329
7Xanthomatosis (HP:0000991)6.25705235
8Complement deficiency (HP:0004431)5.64420886
9Hyperlipoproteinemia (HP:0010980)5.58145788
10Joint hemorrhage (HP:0005261)4.88657932
11Hypolipoproteinemia (HP:0010981)4.78156293
12Epidermoid cyst (HP:0200040)4.63742170
13Hyperammonemia (HP:0001987)4.61058416
14Hyperglycinemia (HP:0002154)4.48867437
15Abnormality of the common coagulation pathway (HP:0010990)4.48233269
16Abnormality of methionine metabolism (HP:0010901)4.39908113
17Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.39553004
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.30704554
19Abnormality of aspartate family amino acid metabolism (HP:0010899)4.21588583
20Fat malabsorption (HP:0002630)4.21238747
21Ketosis (HP:0001946)4.20230343
22Abnormality of glutamine family amino acid metabolism (HP:0010902)4.16941616
23Abnormality of complement system (HP:0005339)4.12089927
24Hypoalphalipoproteinemia (HP:0003233)4.12083942
25Abnormality of pyrimidine metabolism (HP:0004353)3.96969050
26Hyperglycinuria (HP:0003108)3.93532658
27Abnormality of serine family amino acid metabolism (HP:0010894)3.91417846
28Abnormality of glycine metabolism (HP:0010895)3.91417846
29Conjugated hyperbilirubinemia (HP:0002908)3.82222254
30Abnormality of the intrinsic pathway (HP:0010989)3.81963589
31Hypoglycemic coma (HP:0001325)3.77024775
32Hypercholesterolemia (HP:0003124)3.63691633
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.39763465
34Hyperbilirubinemia (HP:0002904)3.37254267
35Abnormality of fatty-acid metabolism (HP:0004359)3.32780993
36Steatorrhea (HP:0002570)3.21728929
37Abnormality of serum amino acid levels (HP:0003112)3.16773821
38Delayed CNS myelination (HP:0002188)3.15042961
39Abnormality of nucleobase metabolism (HP:0010932)3.07534331
40Hypochromic microcytic anemia (HP:0004840)3.03092355
41Spontaneous abortion (HP:0005268)3.02380928
42Hepatocellular carcinoma (HP:0001402)3.00657094
43Myocardial infarction (HP:0001658)2.95030597
44Ketoacidosis (HP:0001993)2.94066545
45Systemic lupus erythematosus (HP:0002725)2.83694588
46Skin nodule (HP:0200036)2.81650106
47Osteomalacia (HP:0002749)2.81514099
48Reduced antithrombin III activity (HP:0001976)2.80961468
49Metabolic acidosis (HP:0001942)2.75190252
50Fair hair (HP:0002286)2.67854262
51Lethargy (HP:0001254)2.63842577
52Abnormality of purine metabolism (HP:0004352)2.62816971
53Recurrent gram-negative bacterial infections (HP:0005420)2.60245008
54Dicarboxylic aciduria (HP:0003215)2.56488085
55Abnormality of dicarboxylic acid metabolism (HP:0010995)2.56488085
56Vascular calcification (HP:0004934)2.54368940
57Acanthocytosis (HP:0001927)2.54051786
58Glomerulonephritis (HP:0000099)2.52519554
59Pulmonary embolism (HP:0002204)2.49909751
60Purpura (HP:0000979)2.48641332
61Cerebral edema (HP:0002181)2.48254877
62Spastic diplegia (HP:0001264)2.45258690
63Abnormal gallbladder morphology (HP:0012437)2.44646715
64Hypoglycemic seizures (HP:0002173)2.42149234
65Mitral stenosis (HP:0001718)2.40898567
66Cholelithiasis (HP:0001081)2.36715251
67Gout (HP:0001997)2.36053547
68Neonatal onset (HP:0003623)2.35656895
69Irritability (HP:0000737)2.34634834
70Cholecystitis (HP:0001082)2.27370322
71Abnormal gallbladder physiology (HP:0012438)2.27370322
72Cardiovascular calcification (HP:0011915)2.24354891
73Gingival bleeding (HP:0000225)2.21700081
74Amyloidosis (HP:0011034)2.20916708
75Arthropathy (HP:0003040)2.19932534
76Hyperphosphaturia (HP:0003109)2.19606375
77Malnutrition (HP:0004395)2.18119542
78Enlarged kidneys (HP:0000105)2.15670745
79Pancreatitis (HP:0001733)2.14665431
80Menorrhagia (HP:0000132)2.14259794
81Brushfield spots (HP:0001088)2.13461432
82Esophageal varix (HP:0002040)2.13367085
83Bile duct proliferation (HP:0001408)2.12797282
84Abnormal biliary tract physiology (HP:0012439)2.12797282
85Sensorimotor neuropathy (HP:0007141)2.11918359
86Neonatal hypoglycemia (HP:0001998)2.10620943
87Glycosuria (HP:0003076)2.10372217
88Abnormality of urine glucose concentration (HP:0011016)2.10372217
89Thrombophlebitis (HP:0004418)2.08099074
90Vomiting (HP:0002013)2.05711849
91Opisthotonus (HP:0002179)2.03766774
92Generalized aminoaciduria (HP:0002909)2.01747236
93Late onset (HP:0003584)2.01242340
94Poikilocytosis (HP:0004447)1.99742457
95Abnormality of the gallbladder (HP:0005264)1.98612165
96Renal cortical cysts (HP:0000803)1.98200842
97Gangrene (HP:0100758)1.96716129
98Increased serum ferritin (HP:0003281)1.96140345
99Hemorrhage of the eye (HP:0011885)1.95811664
100Hyperinsulinemic hypoglycemia (HP:0000825)1.95132622
101Elevated alkaline phosphatase (HP:0003155)1.94326427
102Rickets (HP:0002748)1.90524436
103Generalized hypopigmentation of hair (HP:0011358)1.88365736
104Abnormality of iron homeostasis (HP:0011031)1.86512812
105Abnormal cartilage morphology (HP:0002763)1.84828744
106Hypophosphatemic rickets (HP:0004912)1.84734837
107Joint swelling (HP:0001386)1.84031716
108Abnormal enzyme/coenzyme activity (HP:0012379)1.83667933
109Abnormality of transition element cation homeostasis (HP:0011030)1.83557470
110Elevated hepatic transaminases (HP:0002910)1.83493033
111Alkalosis (HP:0001948)1.82485590
112Abnormality of proline metabolism (HP:0010907)1.80391844
113Hydroxyprolinuria (HP:0003080)1.80391844
114Cerebral palsy (HP:0100021)1.79390588
115Status epilepticus (HP:0002133)1.79091427
116Abnormality of vitamin metabolism (HP:0100508)1.78926309
117Abnormality of alkaline phosphatase activity (HP:0004379)1.78138510
118Nephritis (HP:0000123)1.76385341
119Abnormal urine phosphate concentration (HP:0012599)1.73900634
120Hyperglycemia (HP:0003074)1.70744920
121Facial shape deformation (HP:0011334)1.69671458
122Potter facies (HP:0002009)1.69671458
123Abnormality of the Achilles tendon (HP:0005109)1.61336027
124Atrioventricular block (HP:0001678)1.61278741
125Epistaxis (HP:0000421)1.60501195
126Blue irides (HP:0000635)1.55989325
127Bifid scrotum (HP:0000048)1.49940095
128Decreased subcutaneous fat (HP:0001002)1.45353854

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.21271682
2FGFR44.76616325
3SIK14.54815804
4ERN14.07913857
5TAOK33.17279448
6INSRR3.10519211
7ERBB43.08594994
8MAP2K42.33418500
9WNK32.26960099
10ADRBK22.16009874
11MST1R2.13943514
12PKN22.01095751
13MAPK111.98587532
14FLT31.92786001
15TYK21.86436761
16PIK3CG1.82448368
17MAP4K21.72600428
18TLK11.71513904
19CASK1.66965903
20LATS11.64356572
21ABL21.56245511
22FRK1.55726040
23FGFR21.52343402
24CAMKK21.50207771
25NEK91.46408229
26NTRK31.45803427
27DAPK21.45193879
28TNK21.40324896
29PTK61.40219086
30PINK11.31891247
31TRIB31.27374182
32ACVR1B1.27200678
33MAP3K141.26444313
34MUSK1.25963828
35KDR1.23983485
36JAK21.23876650
37BMPR1B1.20490523
38PRKACA1.19625391
39BLK1.18552063
40MAP3K71.16899541
41PRKG11.16246823
42TXK1.12506544
43TBK11.10816211
44JAK11.09507880
45PRKAA21.09097662
46ERBB21.03498471
47MAP2K21.03309421
48GRK61.00166310
49MAPK40.99962577
50STK38L0.99906213
51CAMKK10.99088360
52WNK40.96491740
53MAP2K30.93764182
54PRKCZ0.93756628
55IRAK30.90385229
56TIE10.85414461
57CSNK1D0.84875854
58DYRK20.84287461
59MET0.83594347
60MAPK150.83316013
61ADRBK10.82176878
62MAP3K100.80775602
63PRKCE0.79758491
64MAPK120.79384096
65CDK60.79179989
66CAMK2G0.76812123
67EPHA30.76372387
68IKBKE0.76023503
69PRKACG0.75566976
70MAP3K30.74482604
71FGFR30.72554480
72MAP2K60.71521687
73PAK30.70999944
74CSK0.70494903
75PRKACB0.69142958
76PRKCB0.68877115
77EPHB10.68387127
78MAP3K110.66561301
79SGK30.66524888
80FER0.66436826
81NLK0.64475314
82PRKAA10.63518815
83DYRK1B0.62855850
84MAPK70.62640432
85GRK70.60970789
86GSK3A0.60014485
87CSF1R0.59375634
88RPS6KA30.59001481
89TGFBR20.58654844
90ZAK0.56850039
91TAOK20.56706681
92SGK10.56601124
93CSNK1G10.55541171
94PBK0.55426154
95PRKCQ0.55229441
96SGK20.55163144
97GRK10.54895657
98CAMK1D0.54660353
99CSNK2A10.54355493
100MAP3K40.54051854
101MAPKAPK30.54039923
102PKN10.51678831
103NUAK10.50616332
104CSNK1A10.49759653
105RPS6KA50.47676751
106EPHA40.47675872
107IGF1R0.46095395
108CSNK1E0.44738545
109PTK20.44372946
110PRKCG0.44276437
111IRAK20.44219203
112MAP3K50.43740152
113BRSK20.42776849
114STK160.42568843
115PDPK10.42186357
116MYLK0.41786780
117IRAK10.39971572
118DYRK1A0.39883535
119STK110.38082440
120CSNK2A20.38013792
121OBSCN0.37576002
122CDK40.36932524
123RIPK10.36911340
124CSNK1G20.35002573
125MAP2K10.34880299
126MAP3K60.34193728
127MAP3K130.33952534
128CSNK1G30.33785308
129SGK2230.33650886
130SGK4940.33650886
131EGFR0.33650480
132ICK0.32434671
133RET0.31594857
134AKT30.30993333
135CAMK40.30397901
136KIT0.27408468
137PRKCA0.26455689
138PDK10.26216714
139CSNK1A1L0.25800297
140MTOR0.25078321
141ABL10.24996037
142MAPK30.19865924
143PIK3CA0.18861902
144CHUK0.18265808
145PDK30.16447868

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.61551669
2Nitrogen metabolism_Homo sapiens_hsa009103.57372829
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.40875622
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.37614032
5Arginine biosynthesis_Homo sapiens_hsa002203.08419567
6Complement and coagulation cascades_Homo sapiens_hsa046102.81073962
7Tryptophan metabolism_Homo sapiens_hsa003802.70662935
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.60563792
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.59524730
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.55433457
11Fatty acid degradation_Homo sapiens_hsa000712.43774607
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.35991514
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.27776806
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.16428332
15Butanoate metabolism_Homo sapiens_hsa006502.10729220
16Peroxisome_Homo sapiens_hsa041462.09177610
17Steroid hormone biosynthesis_Homo sapiens_hsa001402.01636679
18Chemical carcinogenesis_Homo sapiens_hsa052041.98018117
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.96512854
20Histidine metabolism_Homo sapiens_hsa003401.91631000
21Propanoate metabolism_Homo sapiens_hsa006401.89294050
22Caffeine metabolism_Homo sapiens_hsa002321.89031462
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.83796721
24PPAR signaling pathway_Homo sapiens_hsa033201.82436714
25Staphylococcus aureus infection_Homo sapiens_hsa051501.79979894
26Retinol metabolism_Homo sapiens_hsa008301.75715311
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.75410051
28Fatty acid metabolism_Homo sapiens_hsa012121.73079139
29beta-Alanine metabolism_Homo sapiens_hsa004101.71112327
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.70571820
31Selenocompound metabolism_Homo sapiens_hsa004501.60205803
32Phenylalanine metabolism_Homo sapiens_hsa003601.59922527
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54164800
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.54050345
35Bile secretion_Homo sapiens_hsa049761.47033350
36Tyrosine metabolism_Homo sapiens_hsa003501.46440088
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.46356832
38Sulfur metabolism_Homo sapiens_hsa009201.34747248
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.33146554
40Pyruvate metabolism_Homo sapiens_hsa006201.31327058
41Starch and sucrose metabolism_Homo sapiens_hsa005001.29843241
42Fatty acid elongation_Homo sapiens_hsa000621.29243970
43ABC transporters_Homo sapiens_hsa020101.20124310
44Steroid biosynthesis_Homo sapiens_hsa001001.19954117
45Folate biosynthesis_Homo sapiens_hsa007901.19664062
46Biosynthesis of amino acids_Homo sapiens_hsa012301.18083919
47Fat digestion and absorption_Homo sapiens_hsa049751.11536949
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08891091
49Carbon metabolism_Homo sapiens_hsa012001.08710342
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99503768
51Maturity onset diabetes of the young_Homo sapiens_hsa049500.98523137
52Vitamin B6 metabolism_Homo sapiens_hsa007500.97182594
53Arginine and proline metabolism_Homo sapiens_hsa003300.94777132
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.94751479
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91435471
56Sulfur relay system_Homo sapiens_hsa041220.90584444
57Vitamin digestion and absorption_Homo sapiens_hsa049770.83327158
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.79542093
59Lysine degradation_Homo sapiens_hsa003100.78878665
60One carbon pool by folate_Homo sapiens_hsa006700.77728193
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66370036
62Glycerolipid metabolism_Homo sapiens_hsa005610.64050860
63Glutathione metabolism_Homo sapiens_hsa004800.63673682
64Pentose phosphate pathway_Homo sapiens_hsa000300.54870727
65Fatty acid biosynthesis_Homo sapiens_hsa000610.48898884
66Metabolic pathways_Homo sapiens_hsa011000.46671616
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.42341088
68Prion diseases_Homo sapiens_hsa050200.40382589
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38629863
70Linoleic acid metabolism_Homo sapiens_hsa005910.25230478
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24720180
72Galactose metabolism_Homo sapiens_hsa000520.23471100
73Fructose and mannose metabolism_Homo sapiens_hsa000510.21242564
74Insulin resistance_Homo sapiens_hsa049310.20393942
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.18967506
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17895948
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.14789126
78Serotonergic synapse_Homo sapiens_hsa047260.09879670
79Glucagon signaling pathway_Homo sapiens_hsa049220.07007261
80Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2457329
81Pertussis_Homo sapiens_hsa05133-0.2444987
82Ether lipid metabolism_Homo sapiens_hsa00565-0.2406615
83Amoebiasis_Homo sapiens_hsa05146-0.2384170
84RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.2351067
85Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.2207053
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2170090
87Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2155255
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2110137
89Renin-angiotensin system_Homo sapiens_hsa04614-0.2058648
90Type II diabetes mellitus_Homo sapiens_hsa04930-0.2001232
91Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1875541
92Hepatitis C_Homo sapiens_hsa05160-0.1828818
93Sphingolipid metabolism_Homo sapiens_hsa00600-0.1808468
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080-0.1792283
95Circadian rhythm_Homo sapiens_hsa04710-0.1554390
96Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1517520
97African trypanosomiasis_Homo sapiens_hsa05143-0.1430966
98Other glycan degradation_Homo sapiens_hsa00511-0.1385898
99Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1346597
100Insulin signaling pathway_Homo sapiens_hsa04910-0.1269531
101Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1154922
102Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.1149999
103Regulation of autophagy_Homo sapiens_hsa04140-0.1114117
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1001039
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0737122
106Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0688794
107Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0451879
108Mineral absorption_Homo sapiens_hsa04978-0.0128097
109AMPK signaling pathway_Homo sapiens_hsa04152-0.0113738

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