CFI

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uremic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immune deposits and age-related macular degeneration are other conditions associated with mutations of this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.52185871
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.52185871
3L-phenylalanine metabolic process (GO:0006558)7.19603102
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.19603102
5aromatic amino acid family catabolic process (GO:0009074)6.76783841
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.41599994
7indole-containing compound catabolic process (GO:0042436)6.10865135
8indolalkylamine catabolic process (GO:0046218)6.10865135
9tryptophan catabolic process (GO:0006569)6.10865135
10kynurenine metabolic process (GO:0070189)6.00050844
11bile acid biosynthetic process (GO:0006699)5.92810546
12negative regulation of protein activation cascade (GO:2000258)5.87308298
13negative regulation of fibrinolysis (GO:0051918)5.80742227
14exogenous drug catabolic process (GO:0042738)5.78734223
15glyoxylate metabolic process (GO:0046487)5.76690341
16tryptophan metabolic process (GO:0006568)5.75205192
17urea cycle (GO:0000050)5.69531999
18urea metabolic process (GO:0019627)5.69531999
19high-density lipoprotein particle remodeling (GO:0034375)5.69023572
20epoxygenase P450 pathway (GO:0019373)5.60257721
21regulation of fibrinolysis (GO:0051917)5.58340585
22alpha-linolenic acid metabolic process (GO:0036109)5.54989981
23complement activation, alternative pathway (GO:0006957)5.51816652
24regulation of apoptotic cell clearance (GO:2000425)5.51109598
25peptidyl-glutamic acid carboxylation (GO:0017187)5.47385870
26protein carboxylation (GO:0018214)5.47385870
27intestinal cholesterol absorption (GO:0030299)5.40286338
28cysteine metabolic process (GO:0006534)5.32402115
29sulfur amino acid catabolic process (GO:0000098)5.31920378
30* regulation of protein activation cascade (GO:2000257)5.29043478
31nitrogen cycle metabolic process (GO:0071941)5.23033184
32bile acid metabolic process (GO:0008206)5.08627376
33serine family amino acid catabolic process (GO:0009071)5.07406682
34regulation of plasminogen activation (GO:0010755)5.04976226
35negative regulation of complement activation (GO:0045916)5.01741458
36regulation of cholesterol esterification (GO:0010872)5.01739479
37reverse cholesterol transport (GO:0043691)4.99842514
38omega-hydroxylase P450 pathway (GO:0097267)4.94068147
39aromatic amino acid family metabolic process (GO:0009072)4.91653347
40protein-lipid complex remodeling (GO:0034368)4.89411061
41macromolecular complex remodeling (GO:0034367)4.89411061
42plasma lipoprotein particle remodeling (GO:0034369)4.89411061
43regulation of triglyceride catabolic process (GO:0010896)4.88691396
44* regulation of complement activation (GO:0030449)4.87187153
45fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.84553987
46tyrosine metabolic process (GO:0006570)4.76518355
47homocysteine metabolic process (GO:0050667)4.75176755
48phospholipid efflux (GO:0033700)4.69414734
49triglyceride homeostasis (GO:0070328)4.64950702
50acylglycerol homeostasis (GO:0055090)4.64950702
51* regulation of humoral immune response (GO:0002920)4.61738155
52negative regulation of cholesterol transport (GO:0032375)4.61155575
53negative regulation of sterol transport (GO:0032372)4.61155575
54alpha-amino acid catabolic process (GO:1901606)4.60295974
55amino-acid betaine metabolic process (GO:0006577)4.58832297
56lysine metabolic process (GO:0006553)4.57077423
57lysine catabolic process (GO:0006554)4.57077423
58negative regulation of hemostasis (GO:1900047)4.54117689
59negative regulation of blood coagulation (GO:0030195)4.54117689
60plasma lipoprotein particle clearance (GO:0034381)4.49068977
61positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.46298429
62bile acid and bile salt transport (GO:0015721)4.42574318
63cellular ketone body metabolic process (GO:0046950)4.42130818
64glycine metabolic process (GO:0006544)4.39058416
65cholesterol efflux (GO:0033344)4.33228495
66indolalkylamine metabolic process (GO:0006586)4.32602417
67imidazole-containing compound metabolic process (GO:0052803)4.31140101
68coenzyme catabolic process (GO:0009109)4.28859607
69negative regulation of coagulation (GO:0050819)4.26146432
70cellular glucuronidation (GO:0052695)4.24131128
71cellular amino acid catabolic process (GO:0009063)4.23273586
72cellular biogenic amine catabolic process (GO:0042402)4.23236025
73amine catabolic process (GO:0009310)4.23236025
74glutamate metabolic process (GO:0006536)4.21067051
75serine family amino acid metabolic process (GO:0009069)4.15218514
76plasma lipoprotein particle assembly (GO:0034377)4.12931449
77fibrinolysis (GO:0042730)4.12464379
78ethanol metabolic process (GO:0006067)4.11950453
79benzene-containing compound metabolic process (GO:0042537)4.09868647
80negative regulation of wound healing (GO:0061045)4.09749799
81protein-lipid complex subunit organization (GO:0071825)4.09264814
82low-density lipoprotein particle remodeling (GO:0034374)4.08994706
83positive regulation of hemostasis (GO:1900048)4.07494554
84positive regulation of blood coagulation (GO:0030194)4.07494554
85ethanol oxidation (GO:0006069)4.04417835
86cellular modified amino acid catabolic process (GO:0042219)4.01830762
87dicarboxylic acid biosynthetic process (GO:0043650)4.01607979
88arginine metabolic process (GO:0006525)4.01260479
89serine family amino acid biosynthetic process (GO:0009070)4.00463924
90drug metabolic process (GO:0017144)3.99393170
91aldehyde catabolic process (GO:0046185)3.97750177
92blood coagulation, intrinsic pathway (GO:0007597)3.96868991
93drug catabolic process (GO:0042737)3.92292774
94negative regulation of humoral immune response (GO:0002921)3.86487836
95positive regulation of lipoprotein lipase activity (GO:0051006)3.84882618
96positive regulation of triglyceride lipase activity (GO:0061365)3.84882618
97ketone body metabolic process (GO:1902224)3.82601093
98very-low-density lipoprotein particle assembly (GO:0034379)3.82559720
99phospholipid homeostasis (GO:0055091)3.82552122
100positive regulation of coagulation (GO:0050820)3.79535846
101positive regulation of lipid catabolic process (GO:0050996)3.79443519
102negative regulation of lipase activity (GO:0060192)3.78978416
103cholesterol homeostasis (GO:0042632)3.78452514
104cofactor catabolic process (GO:0051187)3.77799398
105intestinal absorption (GO:0050892)3.77481378
106glucuronate metabolic process (GO:0019585)3.76207966
107uronic acid metabolic process (GO:0006063)3.76207966
108plasma lipoprotein particle organization (GO:0071827)3.72317118
109sterol homeostasis (GO:0055092)3.72218491
110regulation of bile acid biosynthetic process (GO:0070857)3.71654694
111* protein activation cascade (GO:0072376)3.70851123
112protein-lipid complex assembly (GO:0065005)3.70168325
113carboxylic acid catabolic process (GO:0046395)3.69988565
114organic acid catabolic process (GO:0016054)3.69988565
115cytolysis (GO:0019835)3.69522194
116* complement activation (GO:0006956)3.64219120
117short-chain fatty acid metabolic process (GO:0046459)3.61995683
118* complement activation, classical pathway (GO:0006958)3.61499460
119regulation of cholesterol homeostasis (GO:2000188)3.61390749
120acute-phase response (GO:0006953)3.60944781
121acetyl-CoA metabolic process (GO:0006084)3.60813178
122lipoprotein metabolic process (GO:0042157)3.59540271
123opsonization (GO:0008228)3.58511094
124acute inflammatory response (GO:0002526)3.53471615
125sterol transport (GO:0015918)3.44048403
126cholesterol transport (GO:0030301)3.44048403
127positive regulation of extracellular matrix organization (GO:1903055)3.43470488
128drug transmembrane transport (GO:0006855)3.40199697
129oxidative demethylation (GO:0070989)3.36871246
130regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.34993856
131positive regulation of fatty acid biosynthetic process (GO:0045723)3.24722146
132* regulation of acute inflammatory response (GO:0002673)3.24041006
133phenylpropanoid metabolic process (GO:0009698)3.20043412
134killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.12788456
135disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.12788456
136flavonoid metabolic process (GO:0009812)3.11624160

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.35580041
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.17439474
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.04036888
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.49307801
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.25721187
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.16018996
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.82903636
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.05571738
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.05243112
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.45838774
11TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.07095779
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.00630164
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9899516
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93995431
15CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.81352848
16CDX2_19796622_ChIP-Seq_MESCs_Mouse1.78696788
17TCF4_18268006_ChIP-ChIP_LS174T_Human1.64824551
18FOXA2_19822575_ChIP-Seq_HepG2_Human1.62975529
19FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.59898736
20CLOCK_20551151_ChIP-Seq_293T_Human1.58661179
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.57181346
22HTT_18923047_ChIP-ChIP_STHdh_Human1.56015520
23GATA1_22025678_ChIP-Seq_K562_Human1.45523446
24* HNF4A_19822575_ChIP-Seq_HepG2_Human1.40624555
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27951348
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19469046
27RXRA_24833708_ChIP-Seq_LIVER_Mouse1.19125405
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.18471346
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.18372590
30ESR1_15608294_ChIP-ChIP_MCF-7_Human1.17575645
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16050211
32PIAS1_25552417_ChIP-Seq_VCAP_Human1.14873504
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11817822
34ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08189717
35NFE2_27457419_Chip-Seq_LIVER_Mouse1.01980091
36EP300_21415370_ChIP-Seq_HL-1_Mouse1.01616700
37ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01538615
38IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00227363
39TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.00129023
40GBX2_23144817_ChIP-Seq_PC3_Human0.99768544
41CJUN_26792858_Chip-Seq_BT549_Human0.99110463
42SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98245249
43HIF1A_21447827_ChIP-Seq_MCF-7_Human0.97048284
44TP53_16413492_ChIP-PET_HCT116_Human0.96373048
45EZH2_27294783_Chip-Seq_NPCs_Mouse0.94239346
46CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94107725
47* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.93397323
48PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92832062
49ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92000845
50TP53_18474530_ChIP-ChIP_U2OS_Human0.90415932
51FLI1_27457419_Chip-Seq_LIVER_Mouse0.87871560
52AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87225196
53PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.86570229
54ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.86370405
55OCT4_18555785_Chip-Seq_ESCs_Mouse0.85144820
56IRF8_22096565_ChIP-ChIP_GC-B_Human0.85142862
57RARG_19884340_ChIP-ChIP_MEFs_Mouse0.84999435
58PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.84873271
59* SMAD1_18555785_Chip-Seq_ESCs_Mouse0.83368854
60ZFX_18555785_Chip-Seq_ESCs_Mouse0.83331041
61AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82797367
62NFIB_24661679_ChIP-Seq_LUNG_Mouse0.82716199
63ESRRB_18555785_Chip-Seq_ESCs_Mouse0.81525139
64ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.80876097
65* GATA4_25053715_ChIP-Seq_YYC3_Human0.80621606
66POU3F2_20337985_ChIP-ChIP_501MEL_Human0.79923549
67RUNX1_27457419_Chip-Seq_LIVER_Mouse0.77906157
68BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77744217
69SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.76776579
70PU1_27457419_Chip-Seq_LIVER_Mouse0.76764366
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.76403382
72ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.75955424
73ZNF263_19887448_ChIP-Seq_K562_Human0.75691122
74KAP1_22055183_ChIP-Seq_ESCs_Mouse0.75560880
75RARA_24833708_ChIP-Seq_LIVER_Mouse0.73851274
76STAT3_18555785_Chip-Seq_ESCs_Mouse0.73370573
77SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.73333230
78FOXM1_26456572_ChIP-Seq_MCF-7_Human0.73220953
79Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.72888736
80KLF4_18555785_Chip-Seq_ESCs_Mouse0.72834824
81CTCF_18555785_Chip-Seq_ESCs_Mouse0.72558398
82CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71461071
83SALL4_18804426_ChIP-ChIP_XEN_Mouse0.71174335
84AR_21572438_ChIP-Seq_LNCaP_Human0.71129211
85CRX_20693478_ChIP-Seq_RETINA_Mouse0.70943343
86GATA2_21666600_ChIP-Seq_HMVEC_Human0.70697877
87EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.70681484
88SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.68691014
89AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.68484872
90SOX2_18555785_Chip-Seq_ESCs_Mouse0.67639758
91ESR2_21235772_ChIP-Seq_MCF-7_Human0.67484717
92NMYC_18555785_Chip-Seq_ESCs_Mouse0.67222230
93SUZ12_18555785_Chip-Seq_ESCs_Mouse0.67210521
94CMYC_18555785_Chip-Seq_ESCs_Mouse0.67161880
95RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.66295998
96NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.65607498
97NRF2_20460467_ChIP-Seq_MEFs_Mouse0.65607498
98RARB_24833708_ChIP-Seq_LIVER_Mouse0.62802787
99NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.61160002
100RAD21_21589869_ChIP-Seq_MESCs_Mouse0.60458485
101BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.59765541
102NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.59406776
103CEBPB_22108803_ChIP-Seq_LS180_Human0.57414549
104NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.56925097
105EGR1_19032775_ChIP-ChIP_M12_Human0.54435195
106FOXA1_25552417_ChIP-Seq_VCAP_Human0.54425856
107FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.52633657
108AR_20517297_ChIP-Seq_VCAP_Human0.52333343
109LXR_22292898_ChIP-Seq_THP-1_Human0.51641142
110FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.51374474
111STAT3_1855785_ChIP-Seq_MESCs_Mouse0.51326977
112PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.50848586
113MYC_19915707_ChIP-ChIP_AK7_Human0.50467394
114ESR1_21235772_ChIP-Seq_MCF-7_Human0.48589506
115FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.48527477
116CBP_21632823_ChIP-Seq_H3396_Human0.47888893
117ESET_19884257_ChIP-Seq_ESCs_Mouse0.47702892
118CDX2_20551321_ChIP-Seq_CACO-2_Human0.47696915
119STAT1_17558387_ChIP-Seq_HELA_Human0.46844985
120E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.46333840
121P53_21459846_ChIP-Seq_SAOS-2_Human0.45962625
122PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.45925358
123GATA1_19941826_ChIP-Seq_K562_Human0.45059942
124TAF15_26573619_Chip-Seq_HEK293_Human0.44049007
125* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.43831286
126FOXO3_23340844_ChIP-Seq_DLD1_Human0.43329847
127FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.43324035
128PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.42487111
129ESR1_20079471_ChIP-ChIP_T-47D_Human0.42263957
130GATA6_25053715_ChIP-Seq_YYC3_Human0.42096439
131GATA1_19941827_ChIP-Seq_MEL_Mouse0.41973035
132PPAR_26484153_Chip-Seq_NCI-H1993_Human0.41911579
133GATA2_19941826_ChIP-Seq_K562_Human0.41448457
134TAF2_19829295_ChIP-Seq_ESCs_Human0.40984818
135BCAT_22108803_ChIP-Seq_LS180_Human0.39348019
136CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.38946360
137ERG_21242973_ChIP-ChIP_JURKAT_Human0.37968104
138STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.37888253
139* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.37853483
140GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.35211126
141SOX2_20726797_ChIP-Seq_SW620_Human0.34781495
142SPI1_26923725_Chip-Seq_HPCs_Mouse0.34584904
143LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.34527646
144ERG_20517297_ChIP-Seq_VCAP_Human0.34404860
145SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.34325312
146* MYC_27129775_Chip-Seq_CORNEA_Mouse0.34276304
147CDX2_22108803_ChIP-Seq_LS180_Human0.33862777
148FOXH1_21741376_ChIP-Seq_EPCs_Human0.33771363

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.29696520
2MP0005360_urolithiasis7.57579863
3MP0005085_abnormal_gallbladder_physiolo6.45854636
4MP0005365_abnormal_bile_salt6.17026934
5MP0008875_abnormal_xenobiotic_pharmacok5.09113054
6MP0003806_abnormal_nucleotide_metabolis4.25872644
7MP0003252_abnormal_bile_duct3.89425583
8MP0010329_abnormal_lipoprotein_level3.61471925
9MP0009840_abnormal_foam_cell3.34211169
10MP0005083_abnormal_biliary_tract3.13266391
11MP0003195_calcinosis2.79051193
12MP0005332_abnormal_amino_acid2.73495861
13MP0003122_maternal_imprinting2.71219331
14MP0001666_abnormal_nutrient_absorption2.63214423
15MP0003191_abnormal_cellular_cholesterol2.39907917
16MP0000609_abnormal_liver_physiology2.17196774
17MP0004019_abnormal_vitamin_homeostasis2.13848030
18MP0002118_abnormal_lipid_homeostasis2.09049193
19MP0002138_abnormal_hepatobiliary_system1.97910036
20MP0003868_abnormal_feces_composition1.92116011
21MP0005319_abnormal_enzyme/_coenzyme1.82028556
22MP0001764_abnormal_homeostasis1.66580635
23MP0009697_abnormal_copulation1.63867411
24MP0005584_abnormal_enzyme/coenzyme_acti1.55871169
25MP0003011_delayed_dark_adaptation1.42718987
26MP0005451_abnormal_body_composition1.34458535
27MP0009780_abnormal_chondrocyte_physiolo1.30372325
28MP0003656_abnormal_erythrocyte_physiolo1.30174153
29MP0001915_intracranial_hemorrhage1.28875206
30MP0003186_abnormal_redox_activity1.25398212
31MP0009643_abnormal_urine_homeostasis1.23093959
32MP0002089_abnormal_postnatal_growth/wei1.21983040
33MP0000598_abnormal_liver_morphology1.18520689
34MP0006054_spinal_hemorrhage1.18317456
35MP0003705_abnormal_hypodermis_morpholog1.16326370
36MP0005647_abnormal_sex_gland1.12358507
37MP0000604_amyloidosis1.11203404
38MP0005058_abnormal_lysosome_morphology1.10458335
39MP0004272_abnormal_basement_membrane1.10133788
40MP0000566_synostosis1.09574571
41MP0009764_decreased_sensitivity_to1.05711978
42MP0002254_reproductive_system_inflammat1.05151223
43MP0009763_increased_sensitivity_to1.03518226
44MP0010368_abnormal_lymphatic_system1.01145894
45MP0003123_paternal_imprinting0.97468194
46MP0005636_abnormal_mineral_homeostasis0.93889147
47MP0003950_abnormal_plasma_membrane0.87740877
48MP0005167_abnormal_blood-brain_barrier0.87044132
49* MP0008469_abnormal_protein_level0.86776609
50MP0005408_hypopigmentation0.86554343
51* MP0009642_abnormal_blood_homeostasis0.86378904
52MP0002909_abnormal_adrenal_gland0.86211565
53MP0005084_abnormal_gallbladder_morpholo0.80946323
54MP0008438_abnormal_cutaneous_collagen0.80701062
55MP0005376_homeostasis/metabolism_phenot0.79789925
56MP0006036_abnormal_mitochondrial_physio0.79694552
57MP0005023_abnormal_wound_healing0.79342194
58MP0005257_abnormal_intraocular_pressure0.79121836
59MP0009765_abnormal_xenobiotic_induced0.78562753
60MP0005670_abnormal_white_adipose0.77105539
61MP0002078_abnormal_glucose_homeostasis0.76982714
62MP0002282_abnormal_trachea_morphology0.75743531
63MP0005220_abnormal_exocrine_pancreas0.75591492
64MP0002876_abnormal_thyroid_physiology0.73742900
65MP0002971_abnormal_brown_adipose0.70876326
66MP0005409_darkened_coat_color0.70873524
67MP0001661_extended_life_span0.69565606
68MP0009053_abnormal_anal_canal0.69228161
69MP0005334_abnormal_fat_pad0.67808337
70MP0003690_abnormal_glial_cell0.67465243
71MP0004130_abnormal_muscle_cell0.66770727
72MP0003172_abnormal_lysosome_physiology0.65744239
73MP0005535_abnormal_body_temperature0.64645736
74MP0003329_amyloid_beta_deposits0.63197410
75MP0005266_abnormal_metabolism0.63059932
76MP0000639_abnormal_adrenal_gland0.61682796
77MP0003879_abnormal_hair_cell0.58060500
78MP0001756_abnormal_urination0.57622125
79MP0002933_joint_inflammation0.56537270
80MP0005464_abnormal_platelet_physiology0.56439359
81MP0005448_abnormal_energy_balance0.54936549
82MP0006035_abnormal_mitochondrial_morpho0.53716215
83MP0001270_distended_abdomen0.52949458
84MP0003121_genomic_imprinting0.52580497
85MP0001324_abnormal_eye_pigmentation0.52287440
86MP0004043_abnormal_pH_regulation0.50819223
87MP0002896_abnormal_bone_mineralization0.49454099
88MP0005395_other_phenotype0.49093876
89MP0003632_abnormal_nervous_system0.48266494
90MP0003183_abnormal_peptide_metabolism0.47855897
91MP0005379_endocrine/exocrine_gland_phen0.47524466
92MP0003567_abnormal_fetal_cardiomyocyte0.47036230
93MP0000920_abnormal_myelination0.46722700
94MP0003943_abnormal_hepatobiliary_system0.46492486
95MP0005410_abnormal_fertilization0.46260897
96MP0002928_abnormal_bile_duct0.46092777
97MP0003718_maternal_effect0.46012134
98MP0002822_catalepsy0.45996107
99MP0003638_abnormal_response/metabolism_0.45833371
100MP0002938_white_spotting0.45062533
101MP0008873_increased_physiological_sensi0.44796430
102MP0002136_abnormal_kidney_physiology0.44702346
103MP0008874_decreased_physiological_sensi0.44124109
104MP0003300_gastrointestinal_ulcer0.44030610
105MP0003436_decreased_susceptibility_to0.43484033
106MP0004782_abnormal_surfactant_physiolog0.42204039
107MP0010386_abnormal_urinary_bladder0.41837568
108MP0003724_increased_susceptibility_to0.41717578
109MP0003075_altered_response_to0.40844196
110MP0002128_abnormal_blood_circulation0.40060639
111MP0003953_abnormal_hormone_level0.39965096
112MP0005248_abnormal_Harderian_gland0.39234147
113MP0005166_decreased_susceptibility_to0.38993477
114MP0002295_abnormal_pulmonary_circulatio0.38638032
115MP0005551_abnormal_eye_electrophysiolog0.38567030
116MP0002837_dystrophic_cardiac_calcinosis0.37854426
117MP0008872_abnormal_physiological_respon0.37375534
118MP0003942_abnormal_urinary_system0.37069412
119MP0009672_abnormal_birth_weight0.36667237
120MP0005666_abnormal_adipose_tissue0.35803417
121MP0000579_abnormal_nail_morphology0.34692225
122MP0004381_abnormal_hair_follicle0.34422697
123MP0004883_abnormal_blood_vessel0.34188969
124MP0002796_impaired_skin_barrier0.33682540
125MP0000249_abnormal_blood_vessel0.33031281
126MP0001243_abnormal_dermal_layer0.32918139
127MP0009384_cardiac_valve_regurgitation0.32679139
128MP0009115_abnormal_fat_cell0.32504678
129MP0002168_other_aberrant_phenotype0.30157388
130MP0006082_CNS_inflammation0.29964688
131MP0001853_heart_inflammation0.29831609
132MP0002970_abnormal_white_adipose0.29546107
133MP0000230_abnormal_systemic_arterial0.29362841
134MP0001881_abnormal_mammary_gland0.28931553
135MP0001845_abnormal_inflammatory_respons0.28535238
136MP0005164_abnormal_response_to0.27031734
137MP0002132_abnormal_respiratory_system0.25586003
138MP0002060_abnormal_skin_morphology0.25558293
139MP0004264_abnormal_extraembryonic_tissu0.24685858

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.64332718
2Intrahepatic cholestasis (HP:0001406)7.38538008
3Abnormality of aromatic amino acid family metabolism (HP:0004338)7.37153250
4Prolonged partial thromboplastin time (HP:0003645)6.76202436
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.70205110
6Hypobetalipoproteinemia (HP:0003563)6.51562163
7Xanthomatosis (HP:0000991)6.33192964
8Hyperlipoproteinemia (HP:0010980)5.56660484
9* Glomerulonephritis (HP:0000099)5.05595725
10* Complement deficiency (HP:0004431)4.97840758
11Joint hemorrhage (HP:0005261)4.94093856
12Hypolipoproteinemia (HP:0010981)4.90412757
13Abnormality of the common coagulation pathway (HP:0010990)4.67688946
14Hyperammonemia (HP:0001987)4.61416741
15Epidermoid cyst (HP:0200040)4.51882792
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.48064776
17Hyperglycinemia (HP:0002154)4.39801296
18Hypoalphalipoproteinemia (HP:0003233)4.28159707
19Abnormality of methionine metabolism (HP:0010901)4.26607045
20Abnormality of sulfur amino acid metabolism (HP:0004339)4.23928435
21Ketosis (HP:0001946)4.23432130
22Fat malabsorption (HP:0002630)4.19127731
23Abnormality of glutamine family amino acid metabolism (HP:0010902)4.16905957
24Abnormality of aspartate family amino acid metabolism (HP:0010899)4.11851223
25Hypoglycemic coma (HP:0001325)3.90302097
26Abnormality of glycine metabolism (HP:0010895)3.88545127
27Abnormality of serine family amino acid metabolism (HP:0010894)3.88545127
28Hyperglycinuria (HP:0003108)3.88167361
29Abnormality of the intrinsic pathway (HP:0010989)3.88165537
30Abnormality of pyrimidine metabolism (HP:0004353)3.85161725
31Conjugated hyperbilirubinemia (HP:0002908)3.78410185
32Hypercholesterolemia (HP:0003124)3.68370893
33* Abnormality of complement system (HP:0005339)3.53436059
34Hyperbilirubinemia (HP:0002904)3.39525449
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.33066694
36Abnormality of fatty-acid metabolism (HP:0004359)3.29357313
37Spontaneous abortion (HP:0005268)3.25867253
38* Nephritis (HP:0000123)3.23677276
39Steatorrhea (HP:0002570)3.14132049
40Delayed CNS myelination (HP:0002188)3.07229497
41Hypochromic microcytic anemia (HP:0004840)3.06572579
42Abnormality of nucleobase metabolism (HP:0010932)3.05559593
43Abnormality of serum amino acid levels (HP:0003112)3.05328762
44Hepatocellular carcinoma (HP:0001402)3.03255148
45Ketoacidosis (HP:0001993)3.00129031
46Myocardial infarction (HP:0001658)2.93578074
47Purpura (HP:0000979)2.87012686
48Arthropathy (HP:0003040)2.86578149
49Systemic lupus erythematosus (HP:0002725)2.81592226
50Skin nodule (HP:0200036)2.79860201
51Osteomalacia (HP:0002749)2.74486645
52Metabolic acidosis (HP:0001942)2.73258657
53Acanthocytosis (HP:0001927)2.70708973
54Abnormality of purine metabolism (HP:0004352)2.65758528
55Abnormality of carpal bone ossification (HP:0006257)2.65556765
56Abnormal tarsal ossification (HP:0008369)2.65472370
57Lethargy (HP:0001254)2.59293567
58Vascular calcification (HP:0004934)2.57723037
59Dicarboxylic aciduria (HP:0003215)2.53595151
60Abnormality of dicarboxylic acid metabolism (HP:0010995)2.53595151
61Hypoglycemic seizures (HP:0002173)2.53413861
62Abnormal gallbladder morphology (HP:0012437)2.51864742
63Spastic diplegia (HP:0001264)2.47520881
64Small epiphyses (HP:0010585)2.45677478
65Cholelithiasis (HP:0001081)2.45500596
66Facial shape deformation (HP:0011334)2.43349348
67Potter facies (HP:0002009)2.43349348
68Cholecystitis (HP:0001082)2.42545627
69Abnormal gallbladder physiology (HP:0012438)2.42545627
70Gout (HP:0001997)2.42434234
71Amyloidosis (HP:0011034)2.41715634
72Cerebral edema (HP:0002181)2.41510029
73Mitral stenosis (HP:0001718)2.40537464
74Gingival bleeding (HP:0000225)2.37004741
75Irritability (HP:0000737)2.34435714
76Neonatal onset (HP:0003623)2.33832386
77Cardiovascular calcification (HP:0011915)2.28685990
78Esophageal varix (HP:0002040)2.27255061
79Malnutrition (HP:0004395)2.24312620
80Menorrhagia (HP:0000132)2.21050629
81Pancreatic islet-cell hyperplasia (HP:0004510)2.18909650
82Thrombophlebitis (HP:0004418)2.18316536
83Pancreatitis (HP:0001733)2.15519212
84Late onset (HP:0003584)2.14848260
85Sensorimotor neuropathy (HP:0007141)2.13620991
86Enlarged kidneys (HP:0000105)2.12337822
87Poikilocytosis (HP:0004447)2.12200373
88Brushfield spots (HP:0001088)2.09516751
89Hyperinsulinemic hypoglycemia (HP:0000825)2.05787535
90Vomiting (HP:0002013)2.04722432
91Abnormality of the gallbladder (HP:0005264)2.03799316
92Hemorrhage of the eye (HP:0011885)2.01692205
93Abnormal hand bone ossification (HP:0010660)2.00408934
94Generalized aminoaciduria (HP:0002909)2.00250733
95Opisthotonus (HP:0002179)2.00184020
96Abnormality of iron homeostasis (HP:0011031)1.96432575
97Abnormality of transition element cation homeostasis (HP:0011030)1.93882659
98Increased serum pyruvate (HP:0003542)1.92605537
99Rickets (HP:0002748)1.92186421
100Flat acetabular roof (HP:0003180)1.90017850
101Abnormality of urine glucose concentration (HP:0011016)1.88259193
102Glycosuria (HP:0003076)1.88259193
103Joint swelling (HP:0001386)1.87525669
104Abnormal cartilage morphology (HP:0002763)1.87167534
105Abnormality of proline metabolism (HP:0010907)1.84512703
106Hydroxyprolinuria (HP:0003080)1.84512703
107Renal cortical cysts (HP:0000803)1.83206916
108Hypophosphatemic rickets (HP:0004912)1.83074097
109Abnormal ossification of hand bones (HP:0005921)1.82519178
110Abnormal enzyme/coenzyme activity (HP:0012379)1.81991491
111Elevated hepatic transaminases (HP:0002910)1.80796702
112Protrusio acetabuli (HP:0003179)1.79301494
113Peritonitis (HP:0002586)1.79101156
114Alkalosis (HP:0001948)1.78317531
115Abnormality of the nasal septum (HP:0000419)1.77594725
116Hyperglycemia (HP:0003074)1.77060528
117Abnormality of vitamin metabolism (HP:0100508)1.76661128
118Status epilepticus (HP:0002133)1.76658497
119Broad alveolar ridges (HP:0000187)1.74585202
120Hypothermia (HP:0002045)1.74350060
121Abnormal delivery (HP:0001787)1.74331356
122* Recurrent gram-negative bacterial infections (HP:0005420)1.74132879
123Reticulocytosis (HP:0001923)1.72493618
124Asymmetry of the thorax (HP:0001555)1.72442279
125Pulmonary embolism (HP:0002204)1.70911014
126Cupped ribs (HP:0000887)1.70755277
127Pigmentary retinal degeneration (HP:0001146)1.69859452
128Acute hepatic failure (HP:0006554)1.69334419
129Hyperphosphaturia (HP:0003109)1.69227034
130Abnormality of glycolysis (HP:0004366)1.68156628
131Flared iliac wings (HP:0002869)1.66702652
132Glomerulosclerosis (HP:0000096)1.66121679
133Bifid scrotum (HP:0000048)1.65092651
134Proximal tubulopathy (HP:0000114)1.64598905
135Abnormality of the wing of the ilium (HP:0011867)1.61954316
136Mucopolysacchariduria (HP:0008155)1.61346982
137Urinary glycosaminoglycan excretion (HP:0003541)1.61346982
138Gonadal dysgenesis (HP:0000133)1.61103582
139Coxa vara (HP:0002812)1.59974505
140Fair hair (HP:0002286)1.55927181
141Abnormal foot bone ossification (HP:0010675)1.55582388

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.09437008
2FGFR44.65492585
3SIK14.48492696
4ERN14.39578350
5TAOK33.16459081
6INSRR2.98132692
7ERBB42.95263923
8WNK42.77454897
9MAP2K42.29533142
10PKN22.27316409
11MST1R2.25151790
12LMTK22.16989138
13FGFR11.98580268
14PDGFRA1.97559073
15MAPK111.92769405
16FLT31.91655600
17AKT31.87144791
18PIK3CG1.85762900
19TRIB31.80991835
20NLK1.74114182
21TYK21.71979422
22LATS11.71272201
23FER1.68571045
24DAPK21.60115129
25DDR21.55058766
26PTK61.54628122
27TYRO31.51569223
28STK391.49461057
29FRK1.48646078
30ABL21.47228533
31NEK91.44446755
32MAP3K21.41486389
33FGFR21.35283468
34MAPKAPK31.35173485
35WNK11.32116692
36KDR1.32019310
37JAK21.24146357
38EIF2AK11.19265615
39MAP3K71.17711303
40PRKAA21.11638253
41GRK61.09319557
42ERBB21.08086698
43TBK11.04879153
44PINK11.03560291
45MAP2K31.02969261
46JAK11.01730841
47MAP3K101.01352694
48CDK120.97505460
49MAPK40.97037879
50CDC42BPA0.95565812
51MAP3K140.94302286
52MET0.93442768
53EPHB10.91682338
54BCR0.90681131
55PRKCZ0.90470170
56NTRK30.88328902
57MAP3K30.88213908
58EPHA30.87283515
59STK38L0.85654812
60MAPK150.84785368
61EIF2AK30.83110212
62CDK60.81580768
63BRSK20.78272522
64MAP3K110.78183530
65MAPK120.77129041
66PRKACG0.77028323
67TIE10.74840075
68CAMK2G0.72060064
69MAP3K120.71474713
70PDK20.70963944
71DYRK1B0.70894545
72RIPK10.70678738
73MYLK0.69181920
74CAMK1D0.68918899
75CSK0.68909333
76ACVR1B0.68012085
77GSK3A0.67109881
78PDGFRB0.65938548
79MAP2K60.65846308
80PRKAA10.64290299
81TGFBR20.60328370
82PTK20.60049357
83SGK30.60048826
84FGFR30.58828136
85SGK10.58747381
86MAP4K20.57038048
87MAPK70.54646035
88IKBKE0.53447907
89IRAK30.53429928
90CSF1R0.53082166
91SRC0.51373607
92TRPM70.50847492
93STK30.50126024
94PRKG10.49491943
95PRKCQ0.49172443
96CSNK1D0.48947207
97CSNK1E0.48613866
98PDPK10.48214461
99MAP2K10.47866216
100EEF2K0.46846809
101CSNK1G10.46350851
102GRK10.45328085
103TAOK20.44740488
104IGF1R0.44495261
105NEK10.44280151
106PRKG20.43818363
107MAP3K50.43046885
108RET0.42958071
109BMPR1B0.42952061
110MAP3K130.42786963
111SGK20.42004569
112EPHA40.41995403
113CDK40.40581404
114STK160.40439346
115PRKCE0.39789767
116RPS6KB10.39168531
117PRKCG0.39153725
118FGR0.37254696
119PKN10.36814849
120PRKACA0.36429685
121MTOR0.35952242
122PBK0.35473468
123MAPKAPK50.35395989
124ICK0.35231154
125EGFR0.34903928
126CAMKK20.34517374
127MAP3K60.33953528
128CAMK40.30600567
129RPS6KA30.30330477
130PDK10.29405345
131SGK2230.29355426
132SGK4940.29355426
133MAP3K10.28467418
134PRKACB0.27396608
135STK240.27253458
136MAP2K20.26929537
137PIK3CA0.26353541
138PRKCA0.25975298
139LATS20.25690758
140CSNK1G20.25442809
141PAK30.23792398
142IRAK10.23610427
143EPHA20.22673915
144CSNK1G30.22353905
145BMX0.21999980
146ABL10.20836862
147CAMK1G0.19619342

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.52821361
2Nitrogen metabolism_Homo sapiens_hsa009103.68454097
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.39927723
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.35549023
5Arginine biosynthesis_Homo sapiens_hsa002203.08954133
6* Complement and coagulation cascades_Homo sapiens_hsa046102.81746849
7Tryptophan metabolism_Homo sapiens_hsa003802.68212081
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.66325369
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.62531288
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.54764128
11Fatty acid degradation_Homo sapiens_hsa000712.47345633
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.36522089
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.23729931
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.15308617
15Butanoate metabolism_Homo sapiens_hsa006502.13071050
16Peroxisome_Homo sapiens_hsa041462.05439532
17Chemical carcinogenesis_Homo sapiens_hsa052041.96348544
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.93874969
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.92267558
20Propanoate metabolism_Homo sapiens_hsa006401.91072460
21Histidine metabolism_Homo sapiens_hsa003401.90460687
22PPAR signaling pathway_Homo sapiens_hsa033201.85572647
23Fatty acid metabolism_Homo sapiens_hsa012121.78981872
24Caffeine metabolism_Homo sapiens_hsa002321.76924407
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.76240525
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.73725347
27beta-Alanine metabolism_Homo sapiens_hsa004101.69829768
28Retinol metabolism_Homo sapiens_hsa008301.69782179
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.64277512
30* Staphylococcus aureus infection_Homo sapiens_hsa051501.64184829
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.59732617
32Selenocompound metabolism_Homo sapiens_hsa004501.57959155
33Phenylalanine metabolism_Homo sapiens_hsa003601.56147867
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.50146585
35Bile secretion_Homo sapiens_hsa049761.49752534
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49157481
37Tyrosine metabolism_Homo sapiens_hsa003501.43723014
38Sulfur metabolism_Homo sapiens_hsa009201.35355199
39Pyruvate metabolism_Homo sapiens_hsa006201.35031591
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.31130409
41Fatty acid elongation_Homo sapiens_hsa000621.30829525
42Starch and sucrose metabolism_Homo sapiens_hsa005001.28954537
43Fat digestion and absorption_Homo sapiens_hsa049751.23093332
44Steroid biosynthesis_Homo sapiens_hsa001001.22846025
45Biosynthesis of amino acids_Homo sapiens_hsa012301.20783730
46ABC transporters_Homo sapiens_hsa020101.20625288
47Folate biosynthesis_Homo sapiens_hsa007901.20489964
48Carbon metabolism_Homo sapiens_hsa012001.12776899
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.04467569
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01217688
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99888792
52Vitamin B6 metabolism_Homo sapiens_hsa007500.98044065
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.97290868
54Arginine and proline metabolism_Homo sapiens_hsa003300.96141282
55Sulfur relay system_Homo sapiens_hsa041220.92618753
56Vitamin digestion and absorption_Homo sapiens_hsa049770.89242174
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87461539
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83339238
59Lysine degradation_Homo sapiens_hsa003100.80378382
60One carbon pool by folate_Homo sapiens_hsa006700.75720368
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70918329
62Other glycan degradation_Homo sapiens_hsa005110.70121321
63Glutathione metabolism_Homo sapiens_hsa004800.66976902
64Glycerolipid metabolism_Homo sapiens_hsa005610.66881348
65Pertussis_Homo sapiens_hsa051330.62871205
66Pentose phosphate pathway_Homo sapiens_hsa000300.59021319
67Fatty acid biosynthesis_Homo sapiens_hsa000610.52906804
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47379025
69Metabolic pathways_Homo sapiens_hsa011000.45445443
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44202251
71Mineral absorption_Homo sapiens_hsa049780.40704291
72N-Glycan biosynthesis_Homo sapiens_hsa005100.39626718
73Prion diseases_Homo sapiens_hsa050200.38092400
74ECM-receptor interaction_Homo sapiens_hsa045120.26863838
75Galactose metabolism_Homo sapiens_hsa000520.26798602
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26431919
77Fructose and mannose metabolism_Homo sapiens_hsa000510.24147082
78Linoleic acid metabolism_Homo sapiens_hsa005910.23815442
79Insulin resistance_Homo sapiens_hsa049310.22879456
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.21413174
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20168790
82Sphingolipid metabolism_Homo sapiens_hsa006000.20086943
83Protein digestion and absorption_Homo sapiens_hsa049740.19267337
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.15376044
85Circadian rhythm_Homo sapiens_hsa047100.11366846
86Glucagon signaling pathway_Homo sapiens_hsa049220.09553956
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.02179912
88AMPK signaling pathway_Homo sapiens_hsa041520.01578531
89Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2406190
90Ether lipid metabolism_Homo sapiens_hsa00565-0.2399012
91Bladder cancer_Homo sapiens_hsa05219-0.2379062
92Amoebiasis_Homo sapiens_hsa05146-0.2255768
93Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2229877
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1926349
95Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1817624
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1738212
97Hepatitis C_Homo sapiens_hsa05160-0.1700982
98Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1641915
99Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1637947
100Renin-angiotensin system_Homo sapiens_hsa04614-0.1635836
101Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1549596
102Regulation of autophagy_Homo sapiens_hsa04140-0.1532412
103African trypanosomiasis_Homo sapiens_hsa05143-0.1340005
104Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1125300
105Insulin signaling pathway_Homo sapiens_hsa04910-0.1042728
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0900511
107Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0737981
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0627407
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0531626
110Lysosome_Homo sapiens_hsa04142-0.0381772

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