CFL1P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.41244132
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.29289225
3Arp2/3 complex-mediated actin nucleation (GO:0034314)5.63272341
4sequestering of actin monomers (GO:0042989)5.40297587
5purine deoxyribonucleotide catabolic process (GO:0009155)5.36503248
6L-fucose catabolic process (GO:0042355)5.31924517
7fucose catabolic process (GO:0019317)5.31924517
8L-fucose metabolic process (GO:0042354)5.31924517
9actin nucleation (GO:0045010)5.07367317
10cytidine deamination (GO:0009972)4.93146876
11cytidine metabolic process (GO:0046087)4.93146876
12cytidine catabolic process (GO:0006216)4.93146876
13platelet dense granule organization (GO:0060155)4.85163253
14response to pheromone (GO:0019236)4.61393868
15negative regulation of telomere maintenance (GO:0032205)4.55244089
16negative regulation of mast cell activation (GO:0033004)4.47488913
17pyrimidine ribonucleoside catabolic process (GO:0046133)4.30733183
18base-excision repair, AP site formation (GO:0006285)4.22782268
19mast cell degranulation (GO:0043303)4.20961170
20mast cell activation involved in immune response (GO:0002279)4.20961170
21immunoglobulin mediated immune response (GO:0016064)3.89180675
22cullin deneddylation (GO:0010388)3.79606906
23protein neddylation (GO:0045116)3.71943359
24negative T cell selection (GO:0043383)3.65984124
25fusion of sperm to egg plasma membrane (GO:0007342)3.63178429
26regulation of gamma-delta T cell differentiation (GO:0045586)3.53123988
27cellular response to interleukin-15 (GO:0071350)3.53015992
28purine deoxyribonucleotide metabolic process (GO:0009151)3.47804941
29ATP synthesis coupled proton transport (GO:0015986)3.47112886
30energy coupled proton transport, down electrochemical gradient (GO:0015985)3.47112886
31mast cell activation (GO:0045576)3.42809361
32protein deneddylation (GO:0000338)3.42758262
33S-adenosylmethionine metabolic process (GO:0046500)3.38516934
34deoxyribonucleotide catabolic process (GO:0009264)3.35444733
35neuronal action potential propagation (GO:0019227)3.30282734
36mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.29981123
37negative thymic T cell selection (GO:0045060)3.28048412
38regulation of cellular amino acid metabolic process (GO:0006521)3.24382958
39positive regulation of T cell mediated cytotoxicity (GO:0001916)3.23586495
40positive thymic T cell selection (GO:0045059)3.22007326
41mannosylation (GO:0097502)3.16997525
42positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.16113121
43tyrosine phosphorylation of STAT protein (GO:0007260)3.14786282
44L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.06131218
45deoxyribose phosphate catabolic process (GO:0046386)3.06030222
46DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.05150633
47GPI anchor biosynthetic process (GO:0006506)3.04746157
48antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.03261737
49glutathione biosynthetic process (GO:0006750)3.02390260
50antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.00455231
51RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.99715100
52tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.99715100
53negative regulation of actin filament bundle assembly (GO:0032232)2.99460101
54phosphorylated carbohydrate dephosphorylation (GO:0046838)2.99323142
55inositol phosphate dephosphorylation (GO:0046855)2.99323142
56negative regulation of nitric-oxide synthase activity (GO:0051001)2.98148239
57signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.97993514
58signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.97993514
59signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.97993514
60plasma membrane fusion (GO:0045026)2.94227568
61positive regulation of gamma-delta T cell activation (GO:0046645)2.93383024
62positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.92611818
63intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.92302166
64signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.92302166
65regulation of T cell mediated cytotoxicity (GO:0001914)2.91506366
66GPI anchor metabolic process (GO:0006505)2.91444207
67B cell mediated immunity (GO:0019724)2.90241444
68proteasome assembly (GO:0043248)2.88274062
69regulation of regulatory T cell differentiation (GO:0045589)2.86179819
70positive T cell selection (GO:0043368)2.85272846
71regulation of leukocyte mediated cytotoxicity (GO:0001910)2.83821394
72regulation of gamma-delta T cell activation (GO:0046643)2.83813122
73antigen processing and presentation of endogenous antigen (GO:0019883)2.81924879
74response to interferon-beta (GO:0035456)2.80045921
75signal transduction involved in DNA integrity checkpoint (GO:0072401)2.79428100
76signal transduction involved in DNA damage checkpoint (GO:0072422)2.79428100
77amino acid salvage (GO:0043102)2.79356201
78L-methionine salvage (GO:0071267)2.79356201
79L-methionine biosynthetic process (GO:0071265)2.79356201
80antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.79031261
81nonribosomal peptide biosynthetic process (GO:0019184)2.77490574
82positive regulation of antigen processing and presentation (GO:0002579)2.76971657
83signal transduction involved in cell cycle checkpoint (GO:0072395)2.76093584
84lysosome localization (GO:0032418)2.75411479
85T cell receptor signaling pathway (GO:0050852)2.74921269
86positive regulation of natural killer cell mediated immunity (GO:0002717)2.74880090
87negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.74842778
88positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.74359991
89positive regulation of cell killing (GO:0031343)2.70675673
90response to xenobiotic stimulus (GO:0009410)2.69494251
91response to interleukin-15 (GO:0070672)2.69200967
92sulfation (GO:0051923)2.68663754
93T cell costimulation (GO:0031295)2.66180884
94negative regulation of T cell apoptotic process (GO:0070233)2.65952390
95fucosylation (GO:0036065)2.63365187
96inositol phosphate catabolic process (GO:0071545)2.63104087
97mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.62931289
98lymphocyte costimulation (GO:0031294)2.62733201
99interferon-gamma secretion (GO:0072643)2.60965316
100nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.57940747

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.52639123
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.35961533
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.93416368
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.34116908
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.30322455
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.27018161
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.01455330
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.98981378
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.54172426
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.52050514
11ZNF274_21170338_ChIP-Seq_K562_Hela2.42657582
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.41287955
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.35229021
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.34876911
15SRF_21415370_ChIP-Seq_HL-1_Mouse2.32041291
16CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.29691503
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.24756897
18VDR_23849224_ChIP-Seq_CD4+_Human2.20567683
19YY1_21170310_ChIP-Seq_MESCs_Mouse2.13954870
20PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.13048122
21VDR_22108803_ChIP-Seq_LS180_Human2.07878142
22FOXP3_21729870_ChIP-Seq_TREG_Human1.95181093
23ETS1_20019798_ChIP-Seq_JURKAT_Human1.94063258
24EST1_17652178_ChIP-ChIP_JURKAT_Human1.93536682
25NOTCH1_21737748_ChIP-Seq_TLL_Human1.93049380
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.91747882
27LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.89096187
28STAT4_19710469_ChIP-ChIP_TH1__Mouse1.88402430
29GATA3_26560356_Chip-Seq_TH2_Human1.88129747
30BP1_19119308_ChIP-ChIP_Hs578T_Human1.86274167
31RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73296496
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.73023469
33MYB_26560356_Chip-Seq_TH2_Human1.71127968
34IRF1_19129219_ChIP-ChIP_H3396_Human1.69415391
35CIITA_25753668_ChIP-Seq_RAJI_Human1.65446671
36BCL6_27268052_Chip-Seq_Bcells_Human1.61346694
37EGR1_23403033_ChIP-Seq_LIVER_Mouse1.59810480
38MYC_18940864_ChIP-ChIP_HL60_Human1.55223701
39SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.51115810
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48854253
41RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.48015886
42GATA3_27048872_Chip-Seq_THYMUS_Human1.47661791
43EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.43709626
44RUNX_20019798_ChIP-Seq_JUKART_Human1.41645310
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.38422343
46CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.37690126
47TP53_22573176_ChIP-Seq_HFKS_Human1.36082739
48IRF8_21731497_ChIP-ChIP_J774_Mouse1.33803026
49PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.31276321
50NANOG_20526341_ChIP-Seq_ESCs_Human1.30121736
51AR_20517297_ChIP-Seq_VCAP_Human1.30098390
52TAF2_19829295_ChIP-Seq_ESCs_Human1.29964081
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.29720000
54IGF1R_20145208_ChIP-Seq_DFB_Human1.27855496
55AUTS2_25519132_ChIP-Seq_293T-REX_Human1.25842661
56ERA_21632823_ChIP-Seq_H3396_Human1.24114401
57FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24067856
58ELK1_19687146_ChIP-ChIP_HELA_Human1.23751040
59LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.23476222
60MYC_19829295_ChIP-Seq_ESCs_Human1.22805175
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22446162
62ELF1_20517297_ChIP-Seq_JURKAT_Human1.22299342
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22217744
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21138057
65NCOR_22424771_ChIP-Seq_293T_Human1.20326337
66GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.17049749
67VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.16069105
68EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.14170502
69GABP_19822575_ChIP-Seq_HepG2_Human1.12841673
70SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.12680049
71CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09412136
72MYC_18358816_ChIP-ChIP_MESCs_Mouse1.08604792
73TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.06547164
74CTCF_20526341_ChIP-Seq_ESCs_Human1.05784995
75FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04643345
76FOXA1_25329375_ChIP-Seq_VCAP_Human1.04643345
77PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04358434
78MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.02625593
79CREB1_15753290_ChIP-ChIP_HEK293T_Human1.01678896
80PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.01037708
81PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.00700850
82MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.00211710
83SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99022176
84HOXB7_26014856_ChIP-Seq_BT474_Human0.97516303
85SPI1_23547873_ChIP-Seq_NB4_Human0.96989647
86PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96802174
87FOXH1_21741376_ChIP-Seq_ESCs_Human0.96028339
88E2F1_20622854_ChIP-Seq_HELA_Human0.95948180
89TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.94390018
90TDRD3_21172665_ChIP-Seq_MCF-7_Human0.94147624
91P300_27268052_Chip-Seq_Bcells_Human0.93831591
92RAC3_21632823_ChIP-Seq_H3396_Human0.92560606
93OCT4_20526341_ChIP-Seq_ESCs_Human0.91582520
94YY1_22570637_ChIP-Seq_MALME-3M_Human0.90459231
95EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.90375939
96E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.89035172
97ERG_20517297_ChIP-Seq_VCAP_Human0.87787580
98MYB_26560356_Chip-Seq_TH1_Human0.87695608
99CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.87090004
100GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.86897813

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.33932212
2MP0002138_abnormal_hepatobiliary_system3.89408445
3MP0002822_catalepsy3.37295619
4MP0001835_abnormal_antigen_presentation3.31365890
5MP0004147_increased_porphyrin_level2.94970977
6MP0009785_altered_susceptibility_to2.70734757
7MP0005075_abnormal_melanosome_morpholog2.67342218
8MP0002102_abnormal_ear_morphology2.58339303
9MP0005000_abnormal_immune_tolerance2.40124739
10MP0002166_altered_tumor_susceptibility2.32039783
11MP0003806_abnormal_nucleotide_metabolis2.25699567
12MP0000685_abnormal_immune_system2.05231033
13MP0002148_abnormal_hypersensitivity_rea2.04590450
14MP0003763_abnormal_thymus_physiology2.00320994
15MP0000465_gastrointestinal_hemorrhage2.00245242
16MP0001800_abnormal_humoral_immune1.95611093
17MP0003724_increased_susceptibility_to1.93399605
18MP0002006_tumorigenesis1.80443231
19MP0003195_calcinosis1.78909269
20MP0002723_abnormal_immune_serum1.78288145
21MP0005025_abnormal_response_to1.77801569
22MP0002420_abnormal_adaptive_immunity1.74658238
23MP0009764_decreased_sensitivity_to1.73848824
24MP0004885_abnormal_endolymph1.73199784
25MP0001819_abnormal_immune_cell1.71288231
26MP0001968_abnormal_touch/_nociception1.71175185
27MP0000015_abnormal_ear_pigmentation1.70113791
28MP0001790_abnormal_immune_system1.67678111
29MP0005387_immune_system_phenotype1.67678111
30MP0009333_abnormal_splenocyte_physiolog1.65769085
31MP0002736_abnormal_nociception_after1.63290402
32MP0003866_abnormal_defecation1.60492736
33MP0003646_muscle_fatigue1.58475737
34MP0002452_abnormal_antigen_presenting1.55393542
35MP0006072_abnormal_retinal_apoptosis1.55318424
36MP0000372_irregular_coat_pigmentation1.50762169
37MP0005645_abnormal_hypothalamus_physiol1.46287475
38MP0001905_abnormal_dopamine_level1.44271277
39MP0005085_abnormal_gallbladder_physiolo1.43815850
40MP0008872_abnormal_physiological_respon1.43643222
41MP0004043_abnormal_pH_regulation1.39324885
42MP0005410_abnormal_fertilization1.35937353
43MP0002933_joint_inflammation1.29840206
44MP0008875_abnormal_xenobiotic_pharmacok1.28896162
45MP0002405_respiratory_system_inflammati1.27213376
46MP0001845_abnormal_inflammatory_respons1.25467269
47MP0000689_abnormal_spleen_morphology1.23658395
48MP0001986_abnormal_taste_sensitivity1.19317938
49MP0005174_abnormal_tail_pigmentation1.18941518
50MP0000716_abnormal_immune_system1.18186394
51MP0002398_abnormal_bone_marrow1.18058752
52MP0005464_abnormal_platelet_physiology1.17205859
53MP0006036_abnormal_mitochondrial_physio1.15900854
54MP0003436_decreased_susceptibility_to1.15378725
55MP0002095_abnormal_skin_pigmentation1.13448231
56MP0001188_hyperpigmentation1.13325668
57MP0003878_abnormal_ear_physiology1.11105714
58MP0005377_hearing/vestibular/ear_phenot1.11105714
59MP0005551_abnormal_eye_electrophysiolog1.10712536
60MP0002722_abnormal_immune_system1.09670729
61MP0003693_abnormal_embryo_hatching1.08747300
62MP0004145_abnormal_muscle_electrophysio1.08379274
63MP0010155_abnormal_intestine_physiology1.07454511
64MP0003786_premature_aging1.02295713
65MP0005253_abnormal_eye_physiology1.01848937
66MP0001542_abnormal_bone_strength1.01560580
67MP0005360_urolithiasis1.01088039
68MP0002419_abnormal_innate_immunity1.00840078
69MP0001919_abnormal_reproductive_system0.99240297
70MP0002272_abnormal_nervous_system0.97241426
71MP0002139_abnormal_hepatobiliary_system0.95988919
72MP0003638_abnormal_response/metabolism_0.95673520
73MP0001764_abnormal_homeostasis0.94966107
74MP0006276_abnormal_autonomic_nervous0.93347633
75MP0005084_abnormal_gallbladder_morpholo0.92396350
76MP0003011_delayed_dark_adaptation0.92078545
77MP0002429_abnormal_blood_cell0.91860440
78MP0001533_abnormal_skeleton_physiology0.89646835
79MP0001873_stomach_inflammation0.89379285
80MP0006082_CNS_inflammation0.89046133
81MP0002837_dystrophic_cardiac_calcinosis0.86324443
82MP0009745_abnormal_behavioral_response0.85736457
83MP0001501_abnormal_sleep_pattern0.84842706
84MP0002876_abnormal_thyroid_physiology0.84662163
85MP0006054_spinal_hemorrhage0.84223312
86MP0008469_abnormal_protein_level0.83653978
87MP0002733_abnormal_thermal_nociception0.82140707
88MP0000703_abnormal_thymus_morphology0.81286171
89MP0005646_abnormal_pituitary_gland0.81122232
90MP0005332_abnormal_amino_acid0.80068566
91MP0001243_abnormal_dermal_layer0.79244443
92MP0005166_decreased_susceptibility_to0.79194504
93MP0002234_abnormal_pharynx_morphology0.77696372
94MP0005365_abnormal_bile_salt0.76451047
95MP0009643_abnormal_urine_homeostasis0.75336467
96MP0000604_amyloidosis0.75326373
97MP0003252_abnormal_bile_duct0.73570479
98MP0004742_abnormal_vestibular_system0.73390125
99MP0005167_abnormal_blood-brain_barrier0.70427141
100MP0001765_abnormal_ion_homeostasis0.69876701

Predicted human phenotypes

RankGene SetZ-score
1IgG deficiency (HP:0004315)4.39818180
2Hypomagnesemia (HP:0002917)4.37604733
3Prostate neoplasm (HP:0100787)4.12552739
4Abnormality of midbrain morphology (HP:0002418)4.02621849
5Molar tooth sign on MRI (HP:0002419)4.02621849
6Abnormality of the prostate (HP:0008775)3.87891688
7Abnormality of magnesium homeostasis (HP:0004921)3.87348335
8Abolished electroretinogram (ERG) (HP:0000550)3.80576348
9Increased IgM level (HP:0003496)3.79389127
10Retinal dysplasia (HP:0007973)3.53948656
11Amyotrophic lateral sclerosis (HP:0007354)3.44362783
12Aplastic anemia (HP:0001915)3.26396426
13Hypoproteinemia (HP:0003075)3.12914208
143-Methylglutaconic aciduria (HP:0003535)3.12625412
15Abnormality of T cell number (HP:0011839)3.02855093
16Stomatitis (HP:0010280)3.02124730
17T lymphocytopenia (HP:0005403)3.01865520
18Severe combined immunodeficiency (HP:0004430)3.01649556
19Pulmonary fibrosis (HP:0002206)2.94040494
20Acute necrotizing encephalopathy (HP:0006965)2.94025651
21Type 2 muscle fiber atrophy (HP:0003554)2.80761631
22Hepatocellular necrosis (HP:0001404)2.80706333
23Abnormality of T cells (HP:0002843)2.80533165
24Increased serum lactate (HP:0002151)2.80255962
25Abnormal mitochondria in muscle tissue (HP:0008316)2.79345877
26Mitochondrial inheritance (HP:0001427)2.75639545
27Muscle fiber atrophy (HP:0100295)2.71376924
28Polyuria (HP:0000103)2.63259803
29Hepatic necrosis (HP:0002605)2.59140414
30Pustule (HP:0200039)2.57666962
31Atrophy/Degeneration involving motor neurons (HP:0007373)2.56709789
32Acute encephalopathy (HP:0006846)2.55221376
33Opisthotonus (HP:0002179)2.54324835
34Stomach cancer (HP:0012126)2.48477410
35Alkalosis (HP:0001948)2.48206859
36Type I transferrin isoform profile (HP:0003642)2.44543065
37Congenital stationary night blindness (HP:0007642)2.42018968
38Decreased electroretinogram (ERG) amplitude (HP:0000654)2.41543322
39Abnormality of eosinophils (HP:0001879)2.41099122
40Abnormality of B cell number (HP:0010975)2.39769551
41Progressive macrocephaly (HP:0004481)2.36997865
42Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.36950192
43Abnormal protein N-linked glycosylation (HP:0012347)2.36950192
44Abnormal protein glycosylation (HP:0012346)2.36950192
45Abnormal glycosylation (HP:0012345)2.36950192
46Elevated erythrocyte sedimentation rate (HP:0003565)2.34857636
47Generalized aminoaciduria (HP:0002909)2.33299202
48Thyroiditis (HP:0100646)2.32826214
49Increased CSF lactate (HP:0002490)2.32513141
50Agitation (HP:0000713)2.28988814
51Lactic acidosis (HP:0003128)2.28431975
52Attenuation of retinal blood vessels (HP:0007843)2.26299728
53Combined immunodeficiency (HP:0005387)2.25284539
54Abnormal urine output (HP:0012590)2.22102173
55Renal salt wasting (HP:0000127)2.21939979
56Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.18902060
57Cerebral palsy (HP:0100021)2.16939532
58Parakeratosis (HP:0001036)2.12095256
59Abnormality of T cell physiology (HP:0011840)2.08657661
60Absent rod-and cone-mediated responses on ERG (HP:0007688)2.03731305
61Pancreatic fibrosis (HP:0100732)2.03649605
62Abnormality of the renal cortex (HP:0011035)2.03104091
63Chronic diarrhea (HP:0002028)2.02928177
64Pancreatic cysts (HP:0001737)2.02517871
65Tetany (HP:0001281)2.02244592
66Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.00480844
67Myositis (HP:0100614)2.00198141
68Chronic sinusitis (HP:0011109)1.99971609
69Decreased activity of mitochondrial respiratory chain (HP:0008972)1.99425081
70Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.99425081
71Encephalitis (HP:0002383)1.99189017
72Microvesicular hepatic steatosis (HP:0001414)1.91016701
73Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.90186583
74Joint swelling (HP:0001386)1.90185099
75Broad-based gait (HP:0002136)1.89268581
76Autoimmune hemolytic anemia (HP:0001890)1.88887666
77Metabolic alkalosis (HP:0200114)1.87831346
78True hermaphroditism (HP:0010459)1.87695253
79Oral leukoplakia (HP:0002745)1.86912516
80Hypoplasia of the capital femoral epiphysis (HP:0003090)1.86383673
81Cerebral edema (HP:0002181)1.86023245
82Hypokalemic alkalosis (HP:0001949)1.84569333
83Nephronophthisis (HP:0000090)1.83075489
84Abnormality of renal excretion (HP:0011036)1.82781621
85Increased intramyocellular lipid droplets (HP:0012240)1.82736315
86Pancytopenia (HP:0001876)1.81701136
87Infantile muscular hypotonia (HP:0008947)1.81246491
88Periorbital edema (HP:0100539)1.80389261
89Delayed CNS myelination (HP:0002188)1.79143721
90Pulmonary infiltrates (HP:0002113)1.78415518
91Optic disc pallor (HP:0000543)1.77666231
92Abnormal drinking behavior (HP:0030082)1.77184543
93Polydipsia (HP:0001959)1.77184543
94Facial edema (HP:0000282)1.76832852
95Reduced antithrombin III activity (HP:0001976)1.76679702
96Abnormality of male internal genitalia (HP:0000022)1.75355012
97Acute hepatic failure (HP:0006554)1.75048523
98Lethargy (HP:0001254)1.74349489
99Progressive neurologic deterioration (HP:0002344)1.72987116
100Cellular immunodeficiency (HP:0005374)1.71629686

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR4.77181459
2TESK24.54365007
3TAOK34.10526579
4TLK13.57590255
5ZAK3.20687863
6TESK12.89528938
7KIT2.88606600
8MAP3K122.74203583
9MAP4K12.35964462
10VRK22.20355349
11LIMK12.20015366
12TXK2.20009474
13TIE12.13781026
14GRK12.11257148
15GRK62.04583618
16MAP4K21.82765519
17ADRBK21.79372110
18BCKDK1.77381914
19SCYL21.69834919
20MST41.60002425
21SYK1.55817135
22PINK11.52964931
23FES1.52102870
24MYLK1.33327964
25FER1.28291107
26VRK11.21437503
27MAPKAPK31.19891507
28DAPK11.15523310
29CSNK1G31.15258472
30ITK1.13915343
31MUSK1.07976474
32TBK11.07660753
33CSNK1A1L1.05158313
34PHKG11.03367454
35PHKG21.03367454
36RPS6KA40.97147547
37NUAK10.95521385
38TEC0.94186585
39MATK0.91774114
40CSNK1G10.90899749
41CDK80.89560184
42STK160.87999222
43TRIM280.86888813
44LYN0.86879736
45WNK30.85586302
46IKBKE0.84285750
47TNK20.83837372
48NME10.82574257
49MAP2K60.82514237
50IKBKB0.80750863
51DYRK20.80708755
52CAMKK10.79835790
53CSNK1G20.77186251
54BTK0.76683838
55RPS6KA50.74534066
56MAP3K110.72313879
57ZAP700.66600958
58GRK50.65687412
59LCK0.64689087
60CSK0.61632829
61MAPK130.61010285
62MAP2K70.60713762
63PASK0.59455278
64FRK0.55548924
65PRKCQ0.55134678
66WNK40.54518020
67BUB10.54299451
68INSRR0.52775562
69CSF1R0.52414372
70SRPK10.50538696
71RIPK40.50056319
72JAK30.49365717
73ADRBK10.46857982
74CAMKK20.45981526
75OXSR10.44441722
76PTK2B0.44235380
77GRK70.43952013
78PRKCI0.43517663
79PIM10.41894879
80BMPR1B0.41191657
81AURKA0.40309997
82SIK30.39662109
83PLK20.39300549
84EIF2AK20.38665407
85ABL10.38535694
86BCR0.37946080
87DAPK30.34927746
88PIM20.34255735
89JAK10.34135688
90ATR0.33359298
91HCK0.33314435
92PRKCA0.33261819
93CDK30.31989549
94BLK0.31566192
95MAP3K50.30431101
96IGF1R0.25238340
97CSNK1A10.23893009
98MAPKAPK50.21909984
99PRKACA0.21458105
100MAP3K40.21350338

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.93742605
2Allograft rejection_Homo sapiens_hsa053303.72312680
3Asthma_Homo sapiens_hsa053103.55463037
4Autoimmune thyroid disease_Homo sapiens_hsa053203.55296520
5Graft-versus-host disease_Homo sapiens_hsa053323.51323858
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.23995632
7Primary immunodeficiency_Homo sapiens_hsa053403.01043556
8Type I diabetes mellitus_Homo sapiens_hsa049402.93235850
9Antigen processing and presentation_Homo sapiens_hsa046122.75483603
10Oxidative phosphorylation_Homo sapiens_hsa001902.42737876
11Sulfur metabolism_Homo sapiens_hsa009202.21346330
12Viral myocarditis_Homo sapiens_hsa054162.03502093
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.02481540
14Parkinsons disease_Homo sapiens_hsa050122.01628080
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.97699389
16Hematopoietic cell lineage_Homo sapiens_hsa046401.87384934
17RNA polymerase_Homo sapiens_hsa030201.66324718
18Rheumatoid arthritis_Homo sapiens_hsa053231.59794459
19Staphylococcus aureus infection_Homo sapiens_hsa051501.37778460
20Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.31784516
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.31053547
22Systemic lupus erythematosus_Homo sapiens_hsa053221.27398837
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.25393985
24Pyruvate metabolism_Homo sapiens_hsa006201.20733578
25Alzheimers disease_Homo sapiens_hsa050101.20390524
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.19941914
27Phototransduction_Homo sapiens_hsa047441.18271422
28Huntingtons disease_Homo sapiens_hsa050161.17568949
29Linoleic acid metabolism_Homo sapiens_hsa005911.11453303
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.06753392
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.03364026
32Base excision repair_Homo sapiens_hsa034101.02220448
33Fatty acid elongation_Homo sapiens_hsa000621.01063205
34Leishmaniasis_Homo sapiens_hsa051400.96788012
35SNARE interactions in vesicular transport_Homo sapiens_hsa041300.96198671
36DNA replication_Homo sapiens_hsa030300.93981338
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91289288
38Collecting duct acid secretion_Homo sapiens_hsa049660.87235117
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86643948
40Shigellosis_Homo sapiens_hsa051310.86030949
41Cysteine and methionine metabolism_Homo sapiens_hsa002700.83538215
42Steroid hormone biosynthesis_Homo sapiens_hsa001400.80751279
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80605247
44Peroxisome_Homo sapiens_hsa041460.79258448
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79022486
46Pyrimidine metabolism_Homo sapiens_hsa002400.78984186
47Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.76740203
48Arachidonic acid metabolism_Homo sapiens_hsa005900.75641047
49Fanconi anemia pathway_Homo sapiens_hsa034600.75462955
50Protein export_Homo sapiens_hsa030600.74256020
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73209526
52Cardiac muscle contraction_Homo sapiens_hsa042600.72771213
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70263854
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70058432
55Purine metabolism_Homo sapiens_hsa002300.67535462
56RNA degradation_Homo sapiens_hsa030180.65923392
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65691089
58Mismatch repair_Homo sapiens_hsa034300.65364815
59Chemical carcinogenesis_Homo sapiens_hsa052040.63065647
60Regulation of autophagy_Homo sapiens_hsa041400.62804760
61Retinol metabolism_Homo sapiens_hsa008300.62585906
62Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62323078
63Nitrogen metabolism_Homo sapiens_hsa009100.62199542
64Nucleotide excision repair_Homo sapiens_hsa034200.61446385
65Herpes simplex infection_Homo sapiens_hsa051680.61117561
66Tryptophan metabolism_Homo sapiens_hsa003800.58746746
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58617885
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58538977
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57905692
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56570423
71T cell receptor signaling pathway_Homo sapiens_hsa046600.56524301
72Ether lipid metabolism_Homo sapiens_hsa005650.54262506
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53310825
74Fat digestion and absorption_Homo sapiens_hsa049750.52503713
75Glutathione metabolism_Homo sapiens_hsa004800.51368798
76Phagosome_Homo sapiens_hsa041450.51353826
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.47702024
78Legionellosis_Homo sapiens_hsa051340.47411921
79Metabolic pathways_Homo sapiens_hsa011000.44873065
80Homologous recombination_Homo sapiens_hsa034400.42231742
81Fatty acid degradation_Homo sapiens_hsa000710.39839712
82NF-kappa B signaling pathway_Homo sapiens_hsa040640.39563051
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.38975340
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38333160
85Epstein-Barr virus infection_Homo sapiens_hsa051690.37191981
86Tuberculosis_Homo sapiens_hsa051520.36594105
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.34533874
88Salmonella infection_Homo sapiens_hsa051320.33834782
89N-Glycan biosynthesis_Homo sapiens_hsa005100.33733489
90Selenocompound metabolism_Homo sapiens_hsa004500.32930487
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.29990398
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.28480223
93Caffeine metabolism_Homo sapiens_hsa002320.27999490
94Spliceosome_Homo sapiens_hsa030400.27705530
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.26716473
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.26506084
97Olfactory transduction_Homo sapiens_hsa047400.25824517
98Malaria_Homo sapiens_hsa051440.24652063
99Vibrio cholerae infection_Homo sapiens_hsa051100.23994154
100Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.21131300

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