ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine nucleobase catabolic process (GO:0006208)	8.83636467
2	type B pancreatic cell proliferation (GO:0044342)	7.15900141
3	nucleobase catabolic process (GO:0046113)	6.93778414
4	response to dietary excess (GO:0002021)	6.66284271
5	hyperosmotic salinity response (GO:0042538)	5.86271110
6	regulation of short-term neuronal synaptic plasticity (GO:0048172)	5.84433059
7	regulation of female receptivity (GO:0045924)	5.59904262
8	regulation of penile erection (GO:0060405)	5.56988987
9	protein localization to synapse (GO:0035418)	5.51560790
10	aggressive behavior (GO:0002118)	5.44730272
11	sequestering of actin monomers (GO:0042989)	5.36622997
12	neurotransmitter catabolic process (GO:0042135)	5.35332090
13	positive regulation of prostaglandin secretion (GO:0032308)	5.22188100
14	cardiac right ventricle morphogenesis (GO:0003215)	5.11293158
15	female mating behavior (GO:0060180)	5.10359650
16	drinking behavior (GO:0042756)	5.05780980
17	positive regulation of uterine smooth muscle contraction (GO:0070474)	5.00872736
18	synaptic vesicle maturation (GO:0016188)	5.00846308
19	axon regeneration (GO:0031103)	4.91265265
20	positive regulation of catecholamine secretion (GO:0033605)	4.88135466
21	embryonic camera-type eye development (GO:0031076)	4.60240730
22	molting cycle (GO:0042303)	4.55998305
23	hair cycle (GO:0042633)	4.55998305
24	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	4.52677559
25	metanephric mesenchyme development (GO:0072075)	4.52620124
26	regulation of prostaglandin secretion (GO:0032306)	4.37004099
27	positive regulation of TOR signaling (GO:0032008)	4.28522021
28	forebrain neuron differentiation (GO:0021879)	4.27903666
29	sleep (GO:0030431)	4.24244116
30	clathrin coat assembly (GO:0048268)	4.21576221
31	respiratory system process (GO:0003016)	4.18127932
32	dermatan sulfate biosynthetic process (GO:0030208)	4.10959838
33	negative regulation of amyloid precursor protein catabolic process (GO:1902992)	4.04218859
34	response to prostaglandin E (GO:0034695)	4.03551402
35	auditory behavior (GO:0031223)	3.96541727
36	positive regulation of digestive system process (GO:0060456)	3.93184800
37	postsynaptic membrane organization (GO:0001941)	3.91775655
38	kidney mesenchyme development (GO:0072074)	3.87177918
39	neuron recognition (GO:0008038)	3.86685913
40	negative regulation of digestive system process (GO:0060457)	3.86613180
41	response to misfolded protein (GO:0051788)	3.84512924
42	type B pancreatic cell development (GO:0003323)	3.81964718
43	dermatan sulfate metabolic process (GO:0030205)	3.81386766
44	dopamine receptor signaling pathway (GO:0007212)	3.81037710
45	synapse assembly (GO:0007416)	3.80101137
46	axon development (GO:0061564)	3.77684816
47	regulation of uterine smooth muscle contraction (GO:0070472)	3.69908040
48	lysine metabolic process (GO:0006553)	3.69885466
49	lysine catabolic process (GO:0006554)	3.69885466
50	skeletal muscle organ development (GO:0060538)	3.65484894
51	establishment of mitochondrion localization (GO:0051654)	3.63968020
52	axon cargo transport (GO:0008088)	3.60137306
53	maternal behavior (GO:0042711)	3.58984549
54	regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	3.58740820
55	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling	3.58740820
56	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	3.55456468
57	mitochondrion transport along microtubule (GO:0047497)	3.55456468
58	aspartate family amino acid catabolic process (GO:0009068)	3.54147610
59	layer formation in cerebral cortex (GO:0021819)	3.53073552
60	neuron projection regeneration (GO:0031102)	3.52649990
61	protein localization to lysosome (GO:0061462)	3.50305436
62	protein localization to vacuole (GO:0072665)	3.50305436
63	axonal fasciculation (GO:0007413)	3.49221837
64	positive regulation of synapse assembly (GO:0051965)	3.47613609
65	cell communication by electrical coupling (GO:0010644)	3.40913199
66	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	3.38332484
67	cellular response to catecholamine stimulus (GO:0071870)	3.37338564
68	cellular response to monoamine stimulus (GO:0071868)	3.37338564
69	negative regulation of microtubule polymerization (GO:0031115)	3.35896434
70	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling	3.35235236
71	response to prostaglandin (GO:0034694)	3.33848846
72	regulation of synaptic vesicle exocytosis (GO:2000300)	3.32149735
73	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	3.31998333
74	chondroitin sulfate catabolic process (GO:0030207)	3.29582085
75	stress fiber assembly (GO:0043149)	3.28317566
76	response to electrical stimulus (GO:0051602)	3.26453850
77	parental behavior (GO:0060746)	3.25610246
78	negative regulation of dendrite morphogenesis (GO:0050774)	3.19610891
79	cerebellar Purkinje cell layer development (GO:0021680)	3.18387083
80	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	3.17915431
81	sexual reproduction (GO:0019953)	3.14603824
82	positive regulation of icosanoid secretion (GO:0032305)	3.14182661
83	glial cell proliferation (GO:0014009)	3.12884235
84	regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	3.09641622
85	generation of neurons (GO:0048699)	3.04999996
86	substantia nigra development (GO:0021762)	3.03494287
87	regulation of microtubule-based movement (GO:0060632)	3.03191231
88	neurofilament cytoskeleton organization (GO:0060052)	3.00304088
89	calcium-mediated signaling using intracellular calcium source (GO:0035584)	2.98153312
90	negative regulation of catenin import into nucleus (GO:0035414)	2.96259241
91	activated T cell proliferation (GO:0050798)	2.95987778
92	synaptic transmission, cholinergic (GO:0007271)	2.94611721
93	response to monoamine (GO:0071867)	2.94584625
94	response to catecholamine (GO:0071869)	2.94584625
95	amyloid precursor protein metabolic process (GO:0042982)	2.94412927
96	mechanosensory behavior (GO:0007638)	2.92699246
97	glutamate secretion (GO:0014047)	2.92371770
98	synapse organization (GO:0050808)	2.90691855
99	positive regulation of fatty acid transport (GO:2000193)	2.90330165
100	epithelial cell differentiation involved in kidney development (GO:0035850)	2.89210432

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	6.27485561
2	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	5.35570340
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.03016704
4	ESR1_15608294_ChIP-ChIP_MCF-7_Human	3.76986043
5	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.28390135
6	TRIM28_21343339_ChIP-Seq_HEK293_Human	2.99076020
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.85100884
8	RNF2_27304074_Chip-Seq_NSC_Mouse	2.70544553
9	EZH2_22144423_ChIP-Seq_EOC_Human	2.70096603
10	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	2.61356724
11	ZFP281_18757296_ChIP-ChIP_E14_Mouse	2.58204941
12	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.47126571
13	REST_18959480_ChIP-ChIP_MESCs_Mouse	2.27711132
14	REST_21632747_ChIP-Seq_MESCs_Mouse	2.24122419
15	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	2.23752131
16	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	2.21898168
17	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.19853124
18	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	2.18323234
19	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.09526322
20	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.07362269
21	ELF1_20517297_ChIP-Seq_JURKAT_Human	2.06086506
22	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.94406758
23	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.93860590
24	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	1.86293313
25	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.84955143
26	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.84773812
27	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.81490465
28	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.81490465
29	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.80906934
30	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.78800605
31	TP53_22127205_ChIP-Seq_IMR90_Human	1.73600082
32	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.72307964
33	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.71901127
34	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.71228582
35	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.68327386
36	ETS1_21867929_ChIP-Seq_TH2_Mouse	1.65035650
37	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.63904120
38	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.60539278
39	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.58868021
40	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.58376934
41	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.56394543
42	CLOCK_20551151_ChIP-Seq_293T_Human	1.55408056
43	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.52042287
44	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.48386350
45	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.46771929
46	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.43615272
47	ZFP281_27345836_Chip-Seq_ESCs_Mouse	1.42860502
48	MEF2A_21415370_ChIP-Seq_HL-1_Mouse	1.37994650
49	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.33285840
50	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.32817302
51	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.32011134
52	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.32009568
53	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.31798507
54	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.30311968
55	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.29039287
56	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.26997451
57	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.26026937
58	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.23090735
59	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.22989989
60	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.19856346
61	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.19331435
62	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.19145239
63	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.19142601
64	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.18686254
65	POU3F1_26484290_ChIP-Seq_ESCss_Mouse	1.15392008
66	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.11849718
67	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.11584650
68	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.11246750
69	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	1.10742100
70	EOMES_21245162_ChIP-Seq_HESCs_Human	1.08623280
71	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.08519415
72	YAP1_20516196_ChIP-Seq_MESCs_Mouse	1.07678621
73	REST_19997604_ChIP-ChIP_NEURONS_Mouse	1.06860932
74	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.06136048
75	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.05994622
76	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.05853605
77	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.05503870
78	SETDB1_19884257_ChIP-Seq_MESCs_Mouse	1.04533909
79	SOX2_18358816_ChIP-ChIP_MESCs_Mouse	1.02207868
80	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.01766253
81	ISL1_27105846_Chip-Seq_CPCs_Mouse	0.99614158
82	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.95705142
83	HTT_18923047_ChIP-ChIP_STHdh_Human	0.95480851
84	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.95109513
85	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	0.94231018
86	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.93411349
87	CJUN_26792858_Chip-Seq_BT549_Human	0.92857506
88	SOX3_22085726_ChIP-Seq_NPCs_Mouse	0.92802514
89	PRDM14_21183938_ChIP-Seq_MESCs_Mouse	0.91901248
90	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.91613811
91	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	0.91610007
92	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.91492263
93	NANOG_18347094_ChIP-ChIP_MESCs_Mouse	0.91096424
94	RING1B_27294783_Chip-Seq_NPCs_Mouse	0.89249730
95	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.88962094
96	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.88130205
97	SMC3_22415368_ChIP-Seq_MEFs_Mouse	0.87780092
98	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.85360536
99	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.84038575
100	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.82328095

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003122_maternal_imprinting	6.91166129
2	MP0006276_abnormal_autonomic_nervous	5.71592932
3	MP0005645_abnormal_hypothalamus_physiol	4.51642553
4	MP0003329_amyloid_beta_deposits	4.28381717
5	MP0004859_abnormal_synaptic_plasticity	4.28368733
6	MP0001502_abnormal_circadian_rhythm	3.93742401
7	MP0000566_synostosis	3.51441619
8	MP0003121_genomic_imprinting	3.24714291
9	MP0001529_abnormal_vocalization	2.91328948
10	MP0003011_delayed_dark_adaptation	2.81180296
11	MP0000778_abnormal_nervous_system	2.79440560
12	MP0000604_amyloidosis	2.40750316
13	MP0001984_abnormal_olfaction	2.31909505
14	MP0004264_abnormal_extraembryonic_tissu	2.28105113
15	MP0002102_abnormal_ear_morphology	2.27755257
16	MP0001440_abnormal_grooming_behavior	2.19682415
17	MP0003635_abnormal_synaptic_transmissio	2.11982109
18	MP0000747_muscle_weakness	1.99557758
19	MP0002822_catalepsy	1.97552901
20	MP0004858_abnormal_nervous_system	1.91661750
21	MP0002557_abnormal_social/conspecific_i	1.88364136
22	MP0004270_analgesia	1.83712542
23	MP0005423_abnormal_somatic_nervous	1.73936582
24	MP0002063_abnormal_learning/memory/cond	1.68967378
25	MP0005386_behavior/neurological_phenoty	1.68629034
26	MP0004924_abnormal_behavior	1.68629034
27	MP0004811_abnormal_neuron_physiology	1.68207916
28	MP0002064_seizures	1.60542959
29	MP0008770_decreased_survivor_rate	1.59398257
30	MP0004272_abnormal_basement_membrane	1.54816015
31	MP0002876_abnormal_thyroid_physiology	1.48720234
32	MP0001905_abnormal_dopamine_level	1.45988984
33	MP0006138_congestive_heart_failure	1.44670859
34	MP0002733_abnormal_thermal_nociception	1.40920791
35	MP0001348_abnormal_lacrimal_gland	1.40140653
36	MP0004142_abnormal_muscle_tone	1.39838440
37	MP0009840_abnormal_foam_cell	1.36560063
38	MP0003634_abnormal_glial_cell	1.35707415
39	MP0002572_abnormal_emotion/affect_behav	1.25038254
40	MP0002332_abnormal_exercise_endurance	1.23616610
41	MP0005257_abnormal_intraocular_pressure	1.23100775
42	MP0002882_abnormal_neuron_morphology	1.21185126
43	MP0001970_abnormal_pain_threshold	1.20604248
44	MP0009745_abnormal_behavioral_response	1.16967269
45	MP0003880_abnormal_central_pattern	1.14201402
46	MP0002152_abnormal_brain_morphology	1.10906357
47	MP0000749_muscle_degeneration	1.09450953
48	MP0002653_abnormal_ependyma_morphology	1.07925905
49	MP0000955_abnormal_spinal_cord	1.07276951
50	MP0003283_abnormal_digestive_organ	1.05903417
51	MP0000631_abnormal_neuroendocrine_gland	1.05397296
52	MP0003632_abnormal_nervous_system	1.04570518
53	MP0001177_atelectasis	1.02617659
54	MP0010386_abnormal_urinary_bladder	0.99337587
55	MP0002909_abnormal_adrenal_gland	0.97489433
56	MP0002067_abnormal_sensory_capabilities	0.96100686
57	MP0009046_muscle_twitch	0.94942184
58	MP0002734_abnormal_mechanical_nocicepti	0.94002876
59	MP0001958_emphysema	0.86060657
60	MP0001881_abnormal_mammary_gland	0.85662526
61	MP0010770_preweaning_lethality	0.82170204
62	MP0002082_postnatal_lethality	0.82170204
63	MP0010769_abnormal_survival	0.81966920
64	MP0002069_abnormal_eating/drinking_beha	0.79904747
65	MP0002184_abnormal_innervation	0.79076309
66	MP0005385_cardiovascular_system_phenoty	0.79001390
67	MP0001544_abnormal_cardiovascular_syste	0.79001390
68	MP0001849_ear_inflammation	0.78187631
69	MP0010768_mortality/aging	0.76500800
70	MP0002066_abnormal_motor_capabilities/c	0.75452477
71	MP0005253_abnormal_eye_physiology	0.74697457
72	MP0002009_preneoplasia	0.73867963
73	MP0002736_abnormal_nociception_after	0.72785607
74	MP0002697_abnormal_eye_size	0.70977256
75	MP0003631_nervous_system_phenotype	0.67452543
76	MP0002752_abnormal_somatic_nervous	0.67292208
77	MP0002638_abnormal_pupillary_reflex	0.63484128
78	MP0008872_abnormal_physiological_respon	0.62925499
79	MP0003861_abnormal_nervous_system	0.61923752
80	MP0005623_abnormal_meninges_morphology	0.60937345
81	MP0008438_abnormal_cutaneous_collagen	0.60018460
82	MP0005195_abnormal_posterior_eye	0.59700331
83	MP0004133_heterotaxia	0.57030624
84	MP0005330_cardiomyopathy	0.56523609
85	MP0003137_abnormal_impulse_conducting	0.56177593
86	MP0002972_abnormal_cardiac_muscle	0.54626024
87	MP0003879_abnormal_hair_cell	0.53782467
88	MP0001486_abnormal_startle_reflex	0.53442643
89	MP0003942_abnormal_urinary_system	0.53028108
90	MP0009703_decreased_birth_body	0.52269518
91	MP0003787_abnormal_imprinting	0.52250648
92	MP0003123_paternal_imprinting	0.50249412
93	MP0002269_muscular_atrophy	0.50092659
94	MP0000647_abnormal_sebaceous_gland	0.49520192
95	MP0003956_abnormal_body_size	0.48481543
96	MP0003633_abnormal_nervous_system	0.47624502
97	MP0002272_abnormal_nervous_system	0.45879959
98	MP0002229_neurodegeneration	0.44809087
99	MP0002081_perinatal_lethality	0.44726092
100	MP0000639_abnormal_adrenal_gland	0.43964992

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Cerebellar dysplasia (HP:0007033)	5.92092311
2	Calf muscle hypertrophy (HP:0008981)	5.80068755
3	Hypoventilation (HP:0002791)	5.65110709
4	Muscle hypertrophy of the lower extremities (HP:0008968)	5.27830624
5	Achilles tendon contracture (HP:0001771)	5.25836735
6	Shoulder girdle muscle weakness (HP:0003547)	5.25451844
7	Type II lissencephaly (HP:0007260)	5.25157947
8	Pelvic girdle muscle weakness (HP:0003749)	5.14106700
9	Limb-girdle muscle atrophy (HP:0003797)	4.94560418
10	Frequent falls (HP:0002359)	4.84907806
11	Abnormality of the musculature of the pelvis (HP:0001469)	4.76595431
12	Abnormality of the hip-girdle musculature (HP:0001445)	4.76595431
13	Abnormality of the Achilles tendon (HP:0005109)	4.70316302
14	Hypoplasia of the pons (HP:0012110)	4.66168153
15	Polyphagia (HP:0002591)	4.58485932
16	Difficulty climbing stairs (HP:0003551)	4.56674224
17	Large eyes (HP:0001090)	4.38184168
18	Hypoplasia of the brainstem (HP:0002365)	4.34119951
19	Aplasia/Hypoplasia of the brainstem (HP:0007362)	4.34119951
20	Mutism (HP:0002300)	4.04183190
21	Abnormality of the pons (HP:0007361)	4.03104469
22	Neurofibrillary tangles (HP:0002185)	3.91792124
23	Insomnia (HP:0100785)	3.73531195
24	Lissencephaly (HP:0001339)	3.71358256
25	Failure to thrive in infancy (HP:0001531)	3.62447055
26	Myokymia (HP:0002411)	3.46714200
27	Overriding aorta (HP:0002623)	3.45303042
28	Elfin facies (HP:0004428)	3.43383981
29	Death in childhood (HP:0003819)	3.26364160
30	Pachygyria (HP:0001302)	3.23642564
31	Limb dystonia (HP:0002451)	3.22228678
32	Abnormal hair whorl (HP:0010721)	3.22081479
33	Hemiplegia (HP:0002301)	3.16480440
34	Cerebral inclusion bodies (HP:0100314)	3.14579223
35	Renovascular hypertension (HP:0100817)	3.13540562
36	Hyperacusis (HP:0010780)	3.04006262
37	Oligomenorrhea (HP:0000876)	3.02522003
38	Abnormality of the labia minora (HP:0012880)	3.00078367
39	Renal duplication (HP:0000075)	2.79220375
40	Supranuclear gaze palsy (HP:0000605)	2.77607377
41	Delayed gross motor development (HP:0002194)	2.75664873
42	Abnormality of the calf musculature (HP:0001430)	2.71712470
43	Hypercortisolism (HP:0001578)	2.71243786
44	Amyotrophic lateral sclerosis (HP:0007354)	2.69787974
45	Growth hormone excess (HP:0000845)	2.68693538
46	Flat cornea (HP:0007720)	2.58604698
47	Akinesia (HP:0002304)	2.56776254
48	Abnormal eating behavior (HP:0100738)	2.54182042
49	Limb-girdle muscle weakness (HP:0003325)	2.53679504
50	Myoglobinuria (HP:0002913)	2.43548497
51	Severe muscular hypotonia (HP:0006829)	2.38674970
52	Megalencephaly (HP:0001355)	2.33164190
53	Proximal amyotrophy (HP:0007126)	2.32336905
54	Pulmonary artery stenosis (HP:0004415)	2.26963236
55	Ankle clonus (HP:0011448)	2.26173759
56	Torticollis (HP:0000473)	2.25211511
57	Esotropia (HP:0000565)	2.21310108
58	Myotonia (HP:0002486)	2.20481848
59	Centrally nucleated skeletal muscle fibers (HP:0003687)	2.20166236
60	Hypercalcemia (HP:0003072)	2.17929568
61	Abnormality of the diencephalon (HP:0010662)	2.17391201
62	Poor suck (HP:0002033)	2.17147002
63	Sleep apnea (HP:0010535)	2.14890695
64	Drooling (HP:0002307)	2.14147088
65	Poor head control (HP:0002421)	2.12721906
66	Atrophy/Degeneration involving motor neurons (HP:0007373)	2.08971996
67	Hip dysplasia (HP:0001385)	2.08241771
68	Cortical dysplasia (HP:0002539)	2.06854250
69	Muscular dystrophy (HP:0003560)	2.03982279
70	Megalocornea (HP:0000485)	2.02146985
71	EMG: myopathic abnormalities (HP:0003458)	2.00242797
72	Excessive salivation (HP:0003781)	1.99029213
73	Hyperthyroidism (HP:0000836)	1.96802523
74	Bladder diverticulum (HP:0000015)	1.95557295
75	Intellectual disability, profound (HP:0002187)	1.94528549
76	Cerebellar hypoplasia (HP:0001321)	1.91727037
77	Generalized hypotonia (HP:0001290)	1.90389467
78	Abnormality of the corticospinal tract (HP:0002492)	1.90115948
79	Sacral dimple (HP:0000960)	1.89961290
80	Morphological abnormality of the pyramidal tract (HP:0002062)	1.83490145
81	Oral leukoplakia (HP:0002745)	1.80477695
82	Spastic gait (HP:0002064)	1.80268019
83	Amyloidosis (HP:0011034)	1.80218816
84	Vertebral fusion (HP:0002948)	1.80025846
85	Agitation (HP:0000713)	1.79762312
86	Fibular hypoplasia (HP:0003038)	1.79693619
87	Decreased muscle mass (HP:0003199)	1.74892431
88	Precocious puberty (HP:0000826)	1.74434213
89	Lower limb amyotrophy (HP:0007210)	1.73974467
90	Fetal akinesia sequence (HP:0001989)	1.71405045
91	Bowel diverticulosis (HP:0005222)	1.70486771
92	Hand muscle atrophy (HP:0009130)	1.69201135
93	Nasal speech (HP:0001611)	1.68917522
94	Shawl scrotum (HP:0000049)	1.66486989
95	Periorbital edema (HP:0100539)	1.66287159
96	Craniofacial dystonia (HP:0012179)	1.65972256
97	Left ventricular hypertrophy (HP:0001712)	1.65726059
98	Abnormality of the vitreous humor (HP:0004327)	1.64858157
99	Pheochromocytoma (HP:0002666)	1.62189096
100	Generalized muscle weakness (HP:0003324)	1.62117153

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MARK1	5.80309239
2	EPHA3	4.12318784
3	LATS2	3.64872061
4	DYRK2	3.33752515
5	TYRO3	3.31778496
6	PHKG1	2.74675323
7	PHKG2	2.74675323
8	FES	2.61942435
9	LMTK2	2.38563670
10	CASK	2.33237654
11	CSNK1G2	2.28657609
12	BCR	1.93575190
13	UHMK1	1.92344126
14	CSNK1G3	1.79316115
15	PRKD3	1.72399261
16	PLK2	1.71140795
17	EPHB1	1.66400185
18	ERN1	1.65871302
19	TESK2	1.62019145
20	CSNK1A1L	1.60019228
21	MAP2K7	1.59564343
22	NTRK1	1.53149297
23	TESK1	1.49340919
24	DYRK3	1.47340074
25	PIM2	1.45304123
26	CSNK1G1	1.39105574
27	ALK	1.33787915
28	DYRK1A	1.30122254
29	LIMK1	1.27231201
30	TNIK	1.23953250
31	PKN1	1.23154878
32	EPHB2	1.20024737
33	ARAF	1.18014623
34	NTRK2	1.12461657
35	MAPK13	1.11556843
36	DYRK1B	1.08576123
37	CLK1	1.07614748
38	PAK3	1.06224269
39	FER	1.04277595
40	PAK6	0.97334426
41	NLK	0.96424405
42	NEK9	0.95989536
43	MAP4K2	0.86751962
44	RPS6KA5	0.86680476
45	GRK5	0.85743183
46	MINK1	0.85266819
47	ZAK	0.84930341
48	MAP3K4	0.82211996
49	FGFR4	0.81725796
50	AURKA	0.79724539
51	VRK1	0.79133552
52	JAK3	0.79059239
53	MARK2	0.78139679
54	PDGFRB	0.77853458
55	MAPK12	0.76171497
56	CDK5	0.74222528
57	CDK14	0.73425440
58	NTRK3	0.72900608
59	CSNK1D	0.69711226
60	TRIM28	0.69511352
61	CHEK2	0.68079303
62	HIPK2	0.66781336
63	AKT2	0.65351990
64	CDK18	0.63009144
65	CDK15	0.59348841
66	FGFR3	0.59019921
67	ROCK2	0.58624193
68	DAPK3	0.56887915
69	PINK1	0.55286963
70	PRKCG	0.54234275
71	TLK1	0.52563536
72	CDK11A	0.50667304
73	TAOK1	0.50127273
74	WNK1	0.49974256
75	MAPK9	0.46424051
76	ILK	0.43569429
77	ROCK1	0.43322741
78	KSR1	0.42773246
79	CSNK1A1	0.42297906
80	RPS6KA2	0.42167032
81	SIK2	0.41889445
82	PRKCD	0.40821704
83	IRAK1	0.39635396
84	SIK3	0.37728759
85	PRKCI	0.36893501
86	PRKCE	0.36615222
87	FYN	0.33056239
88	PRKAA1	0.32659431
89	PTK6	0.31514864
90	CSK	0.30639134
91	JAK1	0.30085234
92	PRKCQ	0.28567064
93	ADRBK2	0.27343311
94	GSK3A	0.27320579
95	PRKCH	0.27266341
96	PRKDC	0.27166624
97	PAK2	0.24110419
98	PRKG1	0.23933776
99	MAP2K6	0.23166461
100	PRKCZ	0.22449209

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	4.21187799
2	Synaptic vesicle cycle_Homo sapiens_hsa04721	3.09946931
3	Alcoholism_Homo sapiens_hsa05034	3.05235851
4	p53 signaling pathway_Homo sapiens_hsa04115	2.77057357
5	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	2.54487960
6	Dopaminergic synapse_Homo sapiens_hsa04728	2.51889011
7	Systemic lupus erythematosus_Homo sapiens_hsa05322	2.32196079
8	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.14622792
9	Lysosome_Homo sapiens_hsa04142	2.14301291
10	Selenocompound metabolism_Homo sapiens_hsa00450	2.07756528
11	Circadian entrainment_Homo sapiens_hsa04713	2.01351995
12	Vibrio cholerae infection_Homo sapiens_hsa05110	2.00255856
13	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.96488293
14	Collecting duct acid secretion_Homo sapiens_hsa04966	1.93377828
15	GABAergic synapse_Homo sapiens_hsa04727	1.88188145
16	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.85966313
17	Cholinergic synapse_Homo sapiens_hsa04725	1.82377747
18	Morphine addiction_Homo sapiens_hsa05032	1.80685151
19	Axon guidance_Homo sapiens_hsa04360	1.70562643
20	Glutamatergic synapse_Homo sapiens_hsa04724	1.68990670
21	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	1.62592466
22	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.58425668
23	Phototransduction_Homo sapiens_hsa04744	1.58132090
24	Notch signaling pathway_Homo sapiens_hsa04330	1.54977074
25	Prion diseases_Homo sapiens_hsa05020	1.47219047
26	Hippo signaling pathway_Homo sapiens_hsa04390	1.38254690
27	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.34775643
28	Cocaine addiction_Homo sapiens_hsa05030	1.33081960
29	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.26829007
30	Tryptophan metabolism_Homo sapiens_hsa00380	1.24422850
31	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.24379696
32	Ether lipid metabolism_Homo sapiens_hsa00565	1.22141263
33	Cardiac muscle contraction_Homo sapiens_hsa04260	1.17123143
34	Gastric acid secretion_Homo sapiens_hsa04971	1.14644065
35	Parkinsons disease_Homo sapiens_hsa05012	1.13754142
36	Insulin secretion_Homo sapiens_hsa04911	1.13722665
37	Salmonella infection_Homo sapiens_hsa05132	1.09988002
38	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.09096492
39	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.06129487
40	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.04813000
41	AMPK signaling pathway_Homo sapiens_hsa04152	1.03614605
42	Oocyte meiosis_Homo sapiens_hsa04114	1.01434644
43	Viral carcinogenesis_Homo sapiens_hsa05203	0.99784894
44	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.99497682
45	Alzheimers disease_Homo sapiens_hsa05010	0.98956926
46	Nicotine addiction_Homo sapiens_hsa05033	0.97916860
47	Nitrogen metabolism_Homo sapiens_hsa00910	0.92916850
48	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.92885926
49	Adherens junction_Homo sapiens_hsa04520	0.92722314
50	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.91555545
51	Linoleic acid metabolism_Homo sapiens_hsa00591	0.91096671
52	Amphetamine addiction_Homo sapiens_hsa05031	0.87448516
53	Steroid biosynthesis_Homo sapiens_hsa00100	0.86039497
54	Endometrial cancer_Homo sapiens_hsa05213	0.84552639
55	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.84466055
56	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.82796773
57	Apoptosis_Homo sapiens_hsa04210	0.81647631
58	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.80521806
59	Serotonergic synapse_Homo sapiens_hsa04726	0.79333088
60	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.77273052
61	Olfactory transduction_Homo sapiens_hsa04740	0.73802917
62	Oxidative phosphorylation_Homo sapiens_hsa00190	0.72297324
63	Gap junction_Homo sapiens_hsa04540	0.72025009
64	Renal cell carcinoma_Homo sapiens_hsa05211	0.71780866
65	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.67726774
66	Huntingtons disease_Homo sapiens_hsa05016	0.67360399
67	Ras signaling pathway_Homo sapiens_hsa04014	0.65057000
68	Salivary secretion_Homo sapiens_hsa04970	0.64749327
69	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.62292439
70	Renin secretion_Homo sapiens_hsa04924	0.62017260
71	Tight junction_Homo sapiens_hsa04530	0.59068011
72	Sphingolipid metabolism_Homo sapiens_hsa00600	0.58957227
73	Estrogen signaling pathway_Homo sapiens_hsa04915	0.54330937
74	Fatty acid elongation_Homo sapiens_hsa00062	0.48407042
75	Colorectal cancer_Homo sapiens_hsa05210	0.47931018
76	Endocytosis_Homo sapiens_hsa04144	0.47595567
77	Proteasome_Homo sapiens_hsa03050	0.47198172
78	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.47152872
79	cAMP signaling pathway_Homo sapiens_hsa04024	0.45743298
80	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.45396165
81	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.45227185
82	Phagosome_Homo sapiens_hsa04145	0.44371019
83	Protein digestion and absorption_Homo sapiens_hsa04974	0.43642670
84	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.43458915
85	Arginine and proline metabolism_Homo sapiens_hsa00330	0.42683106
86	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.41796548
87	Viral myocarditis_Homo sapiens_hsa05416	0.36497397
88	Pancreatic secretion_Homo sapiens_hsa04972	0.36278547
89	Long-term depression_Homo sapiens_hsa04730	0.36088874
90	Shigellosis_Homo sapiens_hsa05131	0.33549406
91	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.31752677
92	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.31097485
93	Melanogenesis_Homo sapiens_hsa04916	0.29582361
94	ErbB signaling pathway_Homo sapiens_hsa04012	0.29338713
95	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.29202888
96	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.28835108
97	Fat digestion and absorption_Homo sapiens_hsa04975	0.27726277
98	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.25111124
99	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.25050251
100	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.24620091

CFL1P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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